Walker, MA
Alexander M. Walker, Concord, MA US
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20090157425 | SYSTEM AND METHOD FOR EARLY IDENTIFICATION OF SAFETY CONCERNS OF NEW DRUGS - A computer-implemented system and method for administering a drug registry database generates a display of a plurality of new drug/comparator drug pairings, wherein each new drug is added to the database when a threshold number of healthcare claims for the new drug have been received. Upon receiving a selection of a new drug/comparator drug pairing, and filter parameters input by a user, an analysis engine searches the healthcare claims stored in the database to identify a first and second group of patients satisfying the filter parameters input by the user; wherein the first group includes patients with claim data indicating use of the new drug and the second group includes patients with claim data indicating use of the comparator drug. The analysis engine further identifies a comparative occurrence of one or more existing medical conditions or new medical conditions in the first and second groups of patients and calculates a probability value indicating a relative likelihood that a patient taking the new drug will have each of the one or more new or existing medical conditions in comparison to a likelihood that a patient taking the comparator drug will have each of the one or more new or existing medical conditions. A user interface displays each new or existing medical condition and the probability value for the new drug and the comparator drug in accordance with one or more report parameters entered by the user. | 06-18-2009 |
20110246228 | System and Method for Early Identification of Safety Concerns of New Drugs - A computer-implemented system and method for administering a drug registry database generates a display of a plurality of new drug/comparator drug pairings, wherein each new drug is added to the database when a threshold number of healthcare claims for the new drug have been received. Upon receiving a selection of a new drug/comparator drug pairing, and filter parameters input by a user, an analysis engine searches the healthcare claims stored in the database to identify a first and second group of patients satisfying the filter parameters input by the user; wherein the first group includes patients with claim data indicating use of the new drug and the second group includes patients with claim data indicating use of the comparator drug. The analysis engine further identifies a comparative occurrence of one or more existing medical conditions or new medical conditions in the first and second groups of patients and calculates a probability value indicating a relative likelihood that a patient taking the new drug will have each of the one or more new or existing medical conditions in comparison to a likelihood that a patient taking the comparator drug will have each of the one or more new or existing medical conditions. A user interface displays each new or existing medical condition and the probability value for the new drug and the comparator drug in accordance with one or more report parameters entered by the user. | 10-06-2011 |
20120323604 | System and Method for Early identification of Safety Concerns of New Drugs - A drug registry database is administered by storing healthcare claims for a plurality of patients and providing a user interface that displays new drug/comparator drug pairings in which a new drug includes a threshold number of healthcare claims and a comparator drug with substantially similar medical indications as the new drug. Based on receiving a new drug/comparator drug pairing selection, an analysis engine identifies from healthcare claims a statistically matched first of patients having used the new drug and second group of patients having used the comparator drug; identifies a comparative occurrence of existing medical conditions or new medical conditions in the statistically matched groups; and calculates a probability value indicating a relative likelihood that a patient taking the new drug will have a medical condition from the new or existing medical conditions in comparison to a likelihood that a patient taking the comparator drug will have the medical condition. | 12-20-2012 |
20140012598 | SYSTEM AND METHOD FOR EARLY IDENTIFICATION OF SAFETY CONCERNS OF NEW DRUGS - A drug registry database is administered by storing healthcare claims for a plurality of patients and providing a user interface that displays new drug/comparator drug pairings in which a new drug includes a threshold number of healthcare claims and a comparator drug with substantially similar medical indications as the new drug. Based on receiving a new drug/comparator drug pairing selection, an analysis engine identifies from healthcare claims a statistically matched first of patients having used the new drug and second group of patients having used the comparator drug; identifies a comparative occurrence of existing medical conditions or new medical conditions in the statistically matched groups; and calculates a probability value indicating a relative likelihood that a patient taking the new drug will have a medical condition from the new or existing medical conditions in comparison to a likelihood that a patient taking the comparator drug will have the medical condition. | 01-09-2014 |
Benjamin P. Walker, Cambridge, MA US
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20150372664 | APPARATUS AND METHODS FOR SWITCH-COUPLED OSCILLATORS - Apparatus and methods for switch-coupled oscillators are disclosed. In certain implementations, an oscillator system includes a primary oscillator, one or more auxiliary oscillators, one or more switching circuits, and an oscillator control circuit. The oscillator control circuit can be used to control the one or more switching circuits to selectively couple the primary oscillator to all or a portion of the one or more auxiliary oscillators. The oscillator control circuit can also disable any auxiliary oscillators that are decoupled from the primary oscillator to reduce power consumption. By selecting a number of auxiliary oscillators to couple to the primary oscillator, the oscillator system can have a configurable phase noise versus power consumption profile. | 12-24-2015 |
Brian J. Walker, Cambridge, MA US
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20150153493 | DEVICE AND METHOD FOR LUMINESCENCE ENHANCEMENT BY RESONANT ENERGY TRANSFER FROM AN ABSORPTIVE THIN FILM - Disclosed are a device and a method for the design and fabrication of the device for enhancing the brightness of luminescent molecules, nanostructures, and thin films. The device includes a mirror, a dielectric medium or spacer, an absorptive layer, and a luminescent layer. The absorptive layer is a continuous thin film of a strongly absorbing organic or inorganic material. The luminescent layer may be a continuous luminescent thin film or an arrangement of isolated luminescent species, e.g., organic or metal-organic dye molecules, semiconductor quantum dots, or other semiconductor nanostructures, supported on top of the absorptive layer. | 06-04-2015 |
Brian J. Walker, Somerville, MA US
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20110278536 | LIGHT EMITTING MATERIAL - A film can include a plurality of semiconductor nanocrystals and a J-aggregating material in solution. The film can exhibit 90% energy transfer efficiency from the J-aggregating material to the plurality of semiconductor nanocrystals. The film can exhibit photoluminescence that is enhanced at least 2.5 times over an equivalent film including the plurality of semiconductor nanocrystals alone when excited at 465 nm. The film can be contacted onto a substrate by spin casting. | 11-17-2011 |
20120138901 | Color Selective Photodetector and Methods of Making - A photoelectric device, such as a photodetector, can include a semiconductor nanowire electrostatically associated with a J-aggregate. The J-aggregate can facilitate absorption of a desired wavelength of light, and the semiconductor nanowire can facilitate charge transport. The color of light detected by the device can be chosen by selecting a J-aggregate with a corresponding peak absorption wavelength. | 06-07-2012 |
Bruce Walker, Nahant, MA US
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20120149592 | Compositions And Methods For Assessing Cytotoxicity Of Single Cells - The invention provides a method of analyzing interactions between pairs of target and effector cells utilizing high-throughput screenings methods for profiling large numbers of single cells in microarrays. | 06-14-2012 |
20130005792 | BIOMARKERS TO IDENTIFY HIV-SPECIFIC T-CELL SUBSETS - The invention relates to expression profiles of HIV-specific T-cells and their methods of use, including but not limited to treatment of HIV, increasing T-cell function and/or survival in HIV infected subjects, monitoring HIV disease progression and classifying HIV infected subjects as controllers or chronic progressors. | 01-03-2013 |
Bruce Walker, Charleston, MA US
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20110008777 | PD-1 MODULATION AND USES THEREOF - Reagents, kits, methods and uses thereof useful for the modulation of immune function, such as the identification of modulators of PD-1 activity, are described. Such reagents, kits, methods and uses thereof may be useful, for example, in the diagnosis, prognostication, prevention and/or treatment of immune-related diseases and/or conditions. | 01-13-2011 |
Bruce D. Walker, Nahant, MA US
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20140170221 | METHODS AND COMPOSITIONS FOR LOCALIZED DELIVERY OF AGENTS TO VIRALLY INFECTED CELLS AND TISSUES - The invention provides compositions and methods for delivering an agent to virally infected tissues and/or cells of a subject by conjugating agent-loaded nanoparticles to virus-specific T cells, such as cytotoxic T lymphocytes. The agent may be a latency-reversing drug (LRD), an antiviral agent and/or an agent that enhances cytotoxic efficacy of T lymphocytes. | 06-19-2014 |
Bruce D. Walker, Milton, MA US
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20090246821 | PEROXIREDOXIN DRUGS FOR TREATMENT OF HIV-1 INFECTION AND METHODS OF USE THEREOF - The invention includes compositions comprising substantially purified peroxiredoxin that are useful in methods for the treatment and prevention of HIV-1 infection. The invention also includes methods for the treatment and prevention of HIV-1 infection comprising contacting a composition of the invention with a human patient. Additionally, the invention includes antibodies and kits useful in the treatment and prevention of HIV-1 infection. | 10-01-2009 |
Bruce J. Walker, Concord, MA US
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20150242970 | Environmental Management Zone Modeling And Analysis - Methods and systems for crop management are disclosed. An example method can comprise receiving first information associated with an environmental management zone. The first information can relate to one or more of a land characteristic and a management practice. The first information can comprise a soil type of the environmental management zone. An example method can comprise, receiving historical weather data relating to the environmental management zone. An example method can comprise receiving real-time weather data relating to the environmental management zone. An example method can comprise executing a growth model to predict a nitrogen range for the environmental management zone based on one or more of the first information, the historical weather data, and the real-time weather data. The nitrogen range can comprise probabilities for one or more of a current time period and a future time period in the growing season. | 08-27-2015 |
Catherine N. Walker, South Deerfield, MA US
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20140296425 | TELECHELIC BASED NETWORKS FROM NOVEL MACROMONOMERS, COMPOSITIONS, PREPARATION AND USES THEREOF - The invention provides highly resilient synthetic hydrogels, which can be prepared, for example, by using the efficient thiol-norbornene chemistry to cross-link hydrophilic poly(ethylene glycol) (PEG) and hydrophobic polydimethylsiloxane (PDMS) polymer chains. The simple hydrogel system with enhanced mechanical properties is useful in many applications, including in the biomedical field and in the design of protective and corrective wear. | 10-02-2014 |
Daniel Walker, Cambridge, MA US
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20080203370 | Powered Rope Ascender and Portable Rope Pulling Device - A device for pulling an elongate member includes a rotational motor having an output and a rotating drum connected to the output of said rotational motor. The device further includes a guide mechanism for guiding the resilient elongate element onto, around at least a portion of the circumference of, and off of, the rotating drum. When the rotational motor turns the rotating drum, the rotating drum thereby continuously pulls the resilient elongate element through the device. | 08-28-2008 |
20130037351 | LOCKING JOINT FOR COLLAPSIBLE LADDERS AND OTHER STRUCTURES - A rigid structure such as a ladder is disclosed having rotating hinges that allow the ladder to fold up and/or be disassembled and assembled. The hinge or hinges can be provided between ladder sections with one ladder section having a male hinge element, and another having a female hinge element. A cam element provided with the female hinge element can be moved between an unlocked position in which the ladder sections can rotate with respect to each other, and a locked position in which the structure is rigid. | 02-14-2013 |
20150034894 | DESCENT ASSIST DEVICE FOR POWERED ASCENDERS - A descent assist device for powered ascenders is discussed herein, In one embodiment, the descent assist device can include a base plate having a first guide surface, a capstan peg, a second guide surface, and a retention loop extending from the first guide surface to the second guide surface configured to retain a rope on the descent assist device. Where the angle of wrapping of the rope around the first guide surface and the capstan peg is constant during use and the angle of wrapping of the rope around the second guide surface is adjustable by the user of the device to increase or decrease the frictional drag of the rope. | 02-05-2015 |
Daniel G. Walker, Cambridge, MA US
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20090143765 | Device for Mixing and Delivering Fluids for Tissue Repair - A device for mixing and delivering a mixture of fluids to a target site includes a tube for containing the mixture. A compressible auger for mixing the fluids is movably disposed within the tube, one end of the auger being free at the distal end of the tube. A plunger is also movable within the tube in communication with the other end of the auger. When the plunger is moved axially within the tube the auger also moves axially and the auger is compressed to dispense the fluid. The mixing and delivery device can be used with an apparatus for the arthroscopic delivery of a tissue repair material to a repair site. The apparatus includes a first sheath and a second sheath removably attached to the first sheath for delivering the tissue repair material to the repair site. | 06-04-2009 |
20130231609 | DEVICE FOR MIXING AND DELIVERING FLUIDS FOR TISSUE REPAIR - A device for mixing and delivering a mixture of fluids to a target site includes a tube for containing the mixture. A compressible auger for mixing the fluids is movably disposed within the tube, one end of the auger being free at the distal end of the tube. A plunger is also movable within the tube in communication with the other end of the auger. When the plunger is moved axially within the tube the auger also moves axially and the auger is compressed to dispense the fluid. The mixing and delivery device can be used with an apparatus for the arthroscopic delivery of a tissue repair material to a repair site. The apparatus includes a first sheath and a second sheath removably attached to the first sheath for delivering the tissue repair material to the repair site. | 09-05-2013 |
Daniel George Walker, Cambridge, MA US
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20090139248 | ENVIRONMENTALLY ADAPTABLE TRANSPORT DEVICE - Disclosed is a device for the transport of temperature sensitive products including an insulated container, an insulated lid, a fastener to secure the lid to the container, an active heat exchanger, a thermal circuit to circulate heat exchange, a temperature sensor read by a temperature regulating circuit that maintains a temperature range, a power source, and a support frame that arranges the elements of the device with the overall center of mass at a location adapted for transport and storage of the device. Disclosed is also a method of transport for temperature sensitive products including securing the temperature sensitive product within an insulated container with a lid, removing heat from the container to maintain a temperature range, strapping the device onto the user's back and adjusting to the shape of the user, freeing both hands during transport of the device, and minimizing hindrances to user mobility caused by the device. | 06-04-2009 |
David H. Walker, Winchester, MA US
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20100170481 | Fog carburetor - A conversion system for a gasoline engine based generator enables the use of heavier fuels. A vertically disposed vortex separation chamber includes an inlet proximate the bottom of the chamber and tangential to the longitudinal axis of the chamber for delivering to the chamber partially vaporized fuel in an air-fuel mixture from a carburetor associated with the engine. An outlet proximate the top of the chamber also tangential to the longitudinal axis of the chamber for delivering vaporized fuel from the chamber to the engine. An electric heater is in communication with the bottom of the chamber for heating the chamber wall to vaporize any fuel thereon so vaporized fuel is reintroduced in swirling air-fuel mixture in the chamber. A battery source charged by the generator provides power to the electric heater. A jacket is disposed about and spaced from the chamber wall creating an annulus between the jacket and the chamber wall. An inlet through the jacket is connected to receive exhaust gas from the engine and to deliver the exhaust gas into the annulus for heating the chamber. | 07-08-2010 |
David Jeffrey Fraser Walker, Amherst, MA US
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20150211022 | METHOD OF PRODUCING A RECOMBINANT MICROORGANISM - The invention provides a genetic tool to insert, replace, delete, or otherwise manipulate a nucleic acid sequence in a microorganism to produce a recombinant microorganism. Notably, the invention makes use of homologous recombination, a type of genetic recombination in which nucleotide sequences are exchanged between two similar or identical molecules of DNA. Since the invention involves three homologous recombination events, it is referred to as a “triple cross” method. | 07-30-2015 |
David Jeffrey Fraser Walker, Boston, MA US
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20150072395 | RECOMBINANT MICROORGANISMS AND METHODS OF USE THEREOF - The present provides selection markers, methods, nucleic acids, and vectors of use in the preparation of recombinant | 03-12-2015 |
Ernest P. Walker, Weston, MA US
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20080285636 | CALIBRATING JITTER - Calibrating jitter in a communication channel between test equipment and a connection for a device under test (DUT) includes sampling test data in the communication channel at about a point of the connection to produce sampled data, where the test data travels through the communication channel at a first rate, and where the test data is sampled at a second rate that is less than the first rate, determining a first amount of jitter in the sampled data relative to the test data, and determining a second amount of jitter at about the point of connection based on the first amount of jitter. | 11-20-2008 |
Graham C. Walker, Cambridge, MA US
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20100222410 | Nuclease compositions and methods - The present invention generally relates to various nucleases and uses thereof, and in some cases, to the UPF0054 protein superfamily. Members of the UPF0054 protein superfamily, such as the | 09-02-2010 |
Gregory S. Walker, Grafton, MA US
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20080289950 | Charge barrier flow-through capacitor-based method of deionizing a fluid - Flow-through capacitors are provided with one or more charge barrier layers. Ions trapped in the pore volume of flow-through capacitors cause inefficiencies as these ions are expelled during the charge cycle into the purification path. A charge barrier layer holds these pore volume ions to one side of a desired flow stream, thereby increasing the efficiency with which the flow-through capacitor purifies or concentrates ions. | 11-27-2008 |
20080290546 | Method of making a charge barrier capacitor electrode - Flow-through capacitors are provided with one or more charge barrier layers. Ions trapped in the pore volume of flow-through capacitors cause inefficiencies as these ions are expelled during the charge cycle into the purification path. A charge barrier layer holds these pore volume ions to one side of a desired flow stream, thereby increasing the efficiency with which the flow-through capacitor purifies or concentrates ions. | 11-27-2008 |
20090090627 | Method of providing a charge barrier flow-through capacitor system - Flow-through capacitors are provided with one or more charge barrier layers. Ions trapped in the pore volume of flow-through capacitors cause inefficiencies as these ions are expelled during the charge cycle into the purification path. A charge barrier layer holds these pore volume ions to one side of a desired flow stream, thereby increasing the efficiency with which the flow-through capacitor purifies or concentrates ions. | 04-09-2009 |
20140346043 | METHOD OF PROVIDING A CHARGE BARRIER FLOW-THROUGH CAPACITOR SYSTEM - Flow-through capacitors are provided with one or more charge barrier layers. Ions trapped in the pore volume of flow-through capacitors cause inefficiencies as these ions are expelled during the charge cycle into the purification path. A charge barrier layer holds these pore volume ions to one side of a desired flow stream, thereby increasing the efficiency with which the flow-through capacitor purifies or concentrates ions. | 11-27-2014 |
Iris Walker, Rowley, MA US
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20090305342 | Solubilization and Purification of a Target Protein fused to a Mutant Maltose-Binding Protein - Methods and compositions are provided for increasing at least one of: (i) binding affinity of a target protein for a maltodextrin substrate and/or (ii) solubility of a target protein. The methods and compositions relate to a modified maltose-binding protein. | 12-10-2009 |
20110020911 | SOLUBILIZATION AND PURIFICATION OF A TARGET PROTEIN FUSED TO A MUTANT MALTOSE-BINDING PROTEIN - Methods and compositions are provided for increasing at least one of: (i) binding affinity of a target protein for a maltodextrin substrate and/or (ii) solubility of a target protein. The methods and compositions relate to a modified maltose-binding protein. | 01-27-2011 |
20120028305 | Solubilization and Purification of a Target Protein Fused to a Mutant Maltose-Binding Protein - Methods and compositions are provided that relate to a composition that includes a modified maltose-binding protein (MBP) which when fused to a protein results in an increase in binding affinity for maltodextrin compared with the wild type MBP fused to the protein, the modified MBP maintaining enhanced solubility, The modification includes a mutation selected from the group consisting of: F68L, I318V, Q326R, V344M, and T | 02-02-2012 |
James Leslie Walker, Maynard, MA US
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20120221456 | SYSTEM AND METHODS FOR FACILITATING OPTIONS AND/OR FUTURES - Some embodiments may include allowing users to define and/or trade in binary options and/or other financial instruments. Various methods and apparatus are described. | 08-30-2012 |
Jason S. Walker, Medford, MA US
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20110077802 | Robot System - A power-saving robot system includes at least one peripheral device and a mobile robot. The peripheral device includes a controller having an active mode and a hibernation mode, and a wireless communication component capable of activation in the hibernation mode. A controller of the robot has an activating routine that communicates with and temporarily activates the peripheral device, via wireless communication, from the hibernation mode. In another aspect, a robot system includes a network data bridge and a mobile robot. The network data bridge includes a broadband network interface, a wireless command interface, and a data bridge component. The data bridge component extracts serial commands received via the broadband network interface from an internet protocol, applies a command protocol thereto, and broadcasts the serial commands via the wireless interface. The mobile robot includes a wireless command communication component that receives the serial commands transmitted from the network data bridge. | 03-31-2011 |
20130253701 | ROBOT SYSTEM - A power-saving robot system includes at least one peripheral device and a mobile robot. The peripheral device includes a controller having an active mode and a hibernation mode, and a wireless communication component capable of activation in the hibernation mode. A controller of the robot has an activating routine that communicates with and temporarily activates the peripheral device, via wireless communication, from the hibernation mode. In another aspect, a robot system includes a network data bridge and a mobile robot. The network data bridge includes a broadband network interface, a wireless command interface, and a data bridge component. The data bridge component extracts serial commands received via the broadband network interface from an internet protocol, applies a command protocol thereto, and broadcasts the serial commands via the wireless interface. The mobile robot includes a wireless command communication component that receives the serial commands transmitted from the network data bridge. | 09-26-2013 |
20140249671 | Robot System - A power-saving robot system includes at least one peripheral device and a mobile robot. The peripheral device includes a controller having an active mode and a hibernation mode, and a wireless communication component capable of activation in the hibernation mode. A controller of the robot has an activating routine that communicates with and temporarily activates the peripheral device, via wireless communication, from the hibernation mode. In another aspect, a robot system includes a network data bridge and a mobile robot. The network data bridge includes a broadband network interface, a wireless command interface, and a data bridge component. The data bridge component extracts serial commands received via the broadband network interface from an internet protocol, applies a command protocol thereto, and broadcasts the serial commands via the wireless interface. The mobile robot includes a wireless command communication component that receives the serial commands transmitted from the network data bridge. | 09-04-2014 |
20140263852 | SPOOLER FOR UNMANNED AERIAL VEHICLE SYSTEM - In an aspect, in general, a spooling apparatus includes a filament feeding mechanism for deploying and retracting filament from the spooling apparatus to an aerial vehicle, an exit geometry sensor for sensing an exit geometry of the filament from the spooling apparatus, and a controller for controlling the feeding mechanism to feed and retract the filament based on the exit geometry. | 09-18-2014 |
Jeffrey W. Walker, Boston, MA US
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20150271540 | Audience-Based Television Advertising Transaction Engine - A computer system provides a virtual marketplace in which an advertising opportunity (such as a television advertising opportunity) is expressed in terms of an audience model representing an audience associated with the advertising opportunity. The computer system provides potential buyers of a particular advertising opportunity with information about the audience model associated with that advertising opportunity. The computer system sells advertising opportunities to buyers using any of a variety of transaction semantics. A buyer who purchases a particular advertising opportunity purchases the opportunity to present an advertisement to an audience represented by the audience model associated with the purchased advertising opportunity. | 09-24-2015 |
Jimmy Walker, Arlington, MA US
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20140255908 | APPARATUS, SYSTEMS, AND METHODS FOR PROCESSING PLATELETS AND CONTAMINATED BLOOD - One aspect of the present disclosure relates to a bag for storing platelets or contaminated blood previously withdrawn from a subject. The bag can comprise a flexible, closed container and at least one removable heat transfer member adhered to an outer surface portion of the container. The container can include an inlet therein that forms part of the container. The inlet can be adapted for fluid-tight connection to a tube member through which the platelets or contaminated blood are caused to flow. | 09-11-2014 |
Joanne Walker, Newton, MA US
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20130004924 | SYSTEMS AND METHODS FOR COMPUTER IMPLEMENTED TREATMENT OF BEHAVIORAL DISORDERS - A system and method are provided for treating excessive or problematic computer use. In at least one embodiment, a method is employed to treat excessive or problematic computer use by acquiring information about the unwanted user activity, monitoring user activity for the unwanted behavior, controlling the behavior when it occurs, enabling the user to record self-observations and evaluating the results. This method may employ a computer based system to treat excessive or problematic computer use which includes configuring a user activity monitor with constraints, programmatically enforcing those constraints, reporting the activities monitored and restricted, and enabling a user to input self-observations. Potential constraints include a complete bar on the user activity, as well as, progressively decreasing the amount of time the user may engage in the activity, i.e. titrating the user activity. | 01-03-2013 |
20140377728 | SYSTEMS AND METHODS FOR COMPUTER IMPLEMENTED TREATMENT OF BEHAVIORAL DISORDERS - A system and method are provided for treating excessive or problematic computer use. In at least one embodiment, a method is employed to treat excessive or problematic computer use by acquiring information about the unwanted user activity, monitoring user activity for the unwanted behavior, controlling the behavior when it occurs, enabling the user to record self-observations and evaluating the results. This method may employ a computer based system to treat excessive or problematic computer use which includes configuring a user activity monitor with constraints, programmatically enforcing those constraints, reporting the activities monitored and restricted, and enabling a user to input self-observations. Potential constraints include a complete bar on the user activity, as well as, progressively decreasing the amount of time the user may engage in the activity, i.e. titrating the user activity. | 12-25-2014 |
John Walker, Bolton, MA US
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20100231284 | Dynamic grounding system and method - Dynamic grounding including monitoring the floating DC outputs of a power amplifier, detecting an imbalance in the floating DC outputs, generating a compensation signal in response to a detected imbalance, and adjusting the power amplifier to re-balance the floating DC outputs and suppress transients. | 09-16-2010 |
John D. Walker, Sudbury, MA US
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20150062855 | HYBRID CIRCUIT ASSEMBLY - A hybrid circuit assembly includes an integrated metal substrate (IMS) having high-voltage, high-power components mounted thereon. The IMS includes a metal base plate an insulating adhesive on the metal base plate, and one or more wiring layers on the insulating adhesive. The hybrid circuit assembly includes a multi-layer printed wiring board (PWB) having low-voltage, low-power components mounted thereon. The multi-layer PWB is connected to the IMS and has an upper surface that is co-planar with an upper surface of the IMS. The PWB is mounted on the metal base plate via the insulating adhesive. | 03-05-2015 |
Laurence G. Walker, Boston, MA US
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20110184910 | Chain-of-Custody for Archived Data - A method that builds a chain-of-custody for archived data is disclosed to ensure the integrity and reliability of the archived data. In one implementation, by using a certified Time Stamp Authority (TSA), an indelible record of each time the archived data is touched (e.g. created, stored, retrieved, accessed, tested, moved, or transformed) is generated to build verifiable links between events to ensure the custody of the data can be audited and verified that it has remained intact throughout its lifetime. The chain-of-custody, in combination with the storage architecture that ensures archive data has not changed through various software and hardware means (e.g., multiple hash signatures to ensure integrity, timestamp authorities to pinpoint each time the archived data was touched, location information to pinpoint physical location, and coordinated chain of custody on multiple replicas of the digital artifact) validates that the archived data has not changed since it was archived. | 07-28-2011 |
Les Walker, Maynard, MA US
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20140244466 | SYSTEMS AND METHODS FOR COMPUTING AN INDEX FOR A BINARY OPTIONS TRANSACTION - Methods, apparatuses, and article of manufactures for receiving a plurality of bids and offers for a binary options instrument. Each bid and offer comprises a quantity and a price. A subset of bids and offers from the plurality of received bids and offers is generated. At least one rule is applied to the subset of bids and offers to generate a reduced subset of bids and offers. A binary options index is computed from the reduced subset of bids and offer. A request for a binary options transaction that is based on the computed binary options index is received. | 08-28-2014 |
20140244467 | SYSTEMS AND METHODS OF DETECTING MANIPULATIONS ON A BINARY OPTIONS EXCHANGE - Methods, apparatuses and article of manufactures for receiving a plurality of bids and offers for a binary options transaction. Each bid and offer comprises a quantity and a price. At least one rule is applied to the plurality of received bids and offers. At least one of the plurality of bids and offers is determined to be potentially manipulative. An alert that the at least one bid or offer is potentially manipulative is transmitted. | 08-28-2014 |
20140245171 | Systems and Methods for Providing Seamless Transitions Between Graphical Images on a Binary Options Interface - Methods, apparatus and article of manufactures for providing seamless transitions between graphical images on a binary options interface. An user-input is received on a touch-sensitive display of the binary options interface. The user-input corresponds to a request for a transformation of a graphical image that is displayed on the binary options interface. The binary options interface is integrated into a mobile device. In response to the user-input, an updated graphical image is generated. The updated graphical image is displayed to replace the graphical image on the binary options interface. The graphical image to the updated graphical image comprises a continuously displayed image. | 08-28-2014 |
Mark B. Walker, Waltham, MA US
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20140125135 | TECHNOLOGY FOR EXTENDING A RADIO FREQUENCY (RF) BANDWIDTH OF AN ENVELOPE TRACKING (ET) POWER AMPLIFIER (PA) - An envelope tracking power supply (ET PS) transmission line switch can be operable between an ET PS and a radio frequency (RF) power amplifier (PA). The ET PS transmission line switch assembly can include a quarter wavelength (¼λ) transmission line configured for high impedance at a specified low RF and a switch coupled to a specified point on the quarter wavelength transmission line to generate a high frequency quarter wavelength transmission line when the switch is toggled. The quarter wavelength transmission line is configured to be coupled to a voltage output of the ET PS and a RF output of the RF PA. The high frequency quarter wavelength transmission line is configured for high impedance at a specified high RF, and the specified high RF is higher than the specified low RF. | 05-08-2014 |
Miles Walker, Somerville, MA US
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20090130706 | PHOTOBIOREACTOR SYSTEMS POSITIONED ON BODIES OF WATER - Certain embodiments and aspects of the present invention relate to a photobioreactor including photobioreactor units through which a liquid medium stream and a gas stream flow. The photobioreactor units are floated on a body of water such as a pond or a lake. The liquid medium comprises at least one species of phototrophic organism therein. Certain methods of using the photobioreactor system as part of fuel generation system and/or a gas-treatment process or system at least partially remove certain undesirable pollutants from a gas stream. In certain embodiments, the photobioreactor units are formed of flexible, deformable material and are configured to provide a substantially constant thickness of liquid medium. In certain embodiments, a barrier between the photobioreactor unit and the body of water upon which the unit is floated facilitates thermal communication between the liquid medium and the body of water. | 05-21-2009 |
Philip Walker, Concord, MA US
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20140364864 | FOOT PEDAL SYSTEM AND APPARATUS - A phacoemulsification system and method, and a surgical foot pedal device, system and method. The present invention may include a console comprising a plurality of modes for at least one physically associated surgical instrument, and a foot pedal communicatively associated with said console and suitable for varying ones of the plurality of modes. The foot pedal may include a housing comprising the communicative association, and comprising at least one potentiometer and at least two top switches for the varying of the ones of the plurality of modes, a treadle rotatably mounted within the housing and suitable for depressing the at least one potentiometer, and at least two side switches movably associated with the treadle for the varying of the ones of the plurality of modes. | 12-11-2014 |
Philip C. Walker, Concord, MA US
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20110118676 | Enteral Connectors and Systems - An enteral connector assembly and system ( | 05-19-2011 |
Randall Walker, Framingham, MA US
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20100009373 | METHODS AND COMPOSITIONS RELATING TO MULTIPLEX GENOMIC GAIN AND LOSS ASSAYS - Compositions and methods are provided for detecting genomic DNA gain and loss. Embodiments of inventive compositions and methods include composite nucleic acid probes which specifically hybridize to two or more genomic loci in a genomic region of a reference genome for detection of genomic gain and/or loss in a subject genome. In some embodiments, a substrate-attached composite nucleic acid probe is provided which includes a mixture of separate populations of beads having attached DNA probes wherein all of the beads are identically encoded and wherein each individual bead has exclusively DNA derived from one source, such as a particular large insert vector containing chromosomal DNA, or amplicons generated by amplification of DNA derived from a large insert vector containing chromosomal DNA. | 01-14-2010 |
20130017974 | METHODS AND COMPOSITIONS RELATING TO MULTIPLEX GENOMIC GAIN AND LOSS ASSAYS - Compositions and methods are provided for detecting genomic DNA gain and loss. Embodiments of inventive compositions and methods include composite nucleic acid probes which specifically hybridize to two or more genomic loci in a genomic region of a reference genome for detection of genomic gain and/or loss in a subject genome. In some embodiments, a substrate-attached composite nucleic acid probe is provided which includes a mixture of separate populations of beads having attached DNA probes wherein all of the beads are identically encoded and wherein each individual bead has exclusively DNA derived from one source, such as a particular large insert vector containing chromosomal DNA, or amplicons generated by amplification of DNA derived from a large insert vector containing chromosomal DNA. | 01-17-2013 |
Robert A. Walker, Westford, MA US
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20140287802 | PHONE CASE WITH WIND FILTER - A case for a handheld wireless device has a case body adapted to receive a handheld wireless device having a microphone. The case has a filter compartment defined by a plurality of walls of the case body and positioned adjacent to the microphone when the handheld wireless device is received in the case body. A sound filter is disposed in the filter compartment and configured to reduce sound received by the microphone opening due to moving air. | 09-25-2014 |
20150193860 | ELECTRONIC COMMERCE SYSTEM AND METHOD - A method of electronic commerce includes a system at a first location receiving a buyer order communicated to the system, wherein the buyer order specifies a plurality of order characteristics selected from product components, product attributes, a product price, and/or delivery terms. The system identifies one or more inventory products of at least one merchant having the order characteristics of the buyer order. The system assigns a value to the inventory product characteristics and the system calculates an inventory score for each inventory product based on an aggregate of the assigned values. The system determines and filters one or more matching inventory products and communicates to the buyer the matching inventory products together with a respective merchant offer to purchase, where the matching inventory products are arranged according to the inventory score. | 07-09-2015 |
Sharon Michele Walker, Boston, MA US
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20150374843 | MULTIVALENT CONSTRUCTS FOR THERAPEUTIC AND DIAGNOSTIC APPLICATIONS - The invention provides compositions and methods for therapeutic and diagnostic applications. | 12-31-2015 |
Sharon Michele Walker, North Attleboro, MA US
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20110070165 | MULTIVALENT CONSTRUCTS FOR THERAPEUTIC AND DIAGNOSTIC APPLICATIONS - The invention provides compositions and methods for therapeutic and diagnostic applications. | 03-24-2011 |
20110286929 | MULTIVALENT CONSTRUCTS FOR THERAPEUTIC AND DIAGNOSTIC APPLICATIONS - The invention provides compositions and methods for therapeutic and diagnostic applications. | 11-24-2011 |
20140205545 | MULTIVALENT CONSTRUCTS FOR THERAPEUTIC AND DIAGNOSTIC APPLICATIONS - The invention provides compositions and methods for therapeutic and diagnostic applications. | 07-24-2014 |
Suzanne Walker, Brookline, MA US
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20100279980 | MOENOMYCIN BIOSYNTHESIS-RELATED COMPOSITIONS AND METHODS OF USE THEREOF - The methods and compositions described herein relate to the identification, isolation, and characterization of genes which encode proteins useful for the biosynthesis of transglycosylase inhibitors such as moes. The methods and compositions also relate to the production of such proteins, and their use in the synthesis of moes, the expression of moes, and the production of modified moes. | 11-04-2010 |
Suzanne Kahne Walker, Brookline, MA US
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20100290987 | METHODS AND COMPOSITIONS FOR DETECTING AND MODULATING O-GLYCOSYLATION - The invention relates to methods and products for modulating glycosylation of proteins. The invention is useful for identifying therapeutic compounds to treat glycosylation-associated disorders such as neurodegeneration, diabetes, including complications of diabetes such as insulin resistance, nephropathy, microvascular damage, and endothelial dysfunction. The invention is also useful for identifying therapeutic compounds to treat de-glycosylation-associated disorders such as ischemic damage and traumatic injury. The invention also relates in part to assays that are useful for identifying and testing candidate compounds for modulating glycosylation of proteins and also relates in part to compounds to treat glycosylation-associated diseases and disorders. | 11-18-2010 |
20110136759 | MOENOMYCIN ANALOGS, METHODS OF SYNTHESIS, AND USES THEREOF - The present invention provides novel moenomycin analogs as well as pharmaceutical compositions thereof, methods of synthesis, and methods of use in treating an infection by administering an inventive compound to a subject in need thereof. The moenomycin analogs may be prepared synthetically, biosynthetically, or semi-synthetically. The analogs are particularly useful in treating or preventing infections caused by Gram-positive organisms. Certain inventive compounds may have a broader spectrum of coverage, which includes Gram-negative organisms. | 06-09-2011 |
Timothy P. Walker, Boxford, MA US
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20090148161 | 10 GBE LAN SIGNAL MAPPING TO OTU2 SIGNAL - A high-capacity digital communications system and method of transporting 10 GbE LAN packets between user devices over an OTN network that allows the packets to be transported in a manner that is transparent to the destination device(s) on the network. The digital communications system includes an OTN network, and at least one source device and at least one destination device connected to the network via respective 10Gbase-R interfaces. The system transports 10 GbE LAN data packets over the OTN network by performing decoding on the packets to recover the preamble and variable length data contained in each packet, removing the IPG between successive packets in the stream, encapsulating the packets including the respective preambles and data, and mapping the encapsulated packets to the overhead and payload areas of ODUk frames. The packets are then transported over the OTN network from the source device to the destination device. | 06-11-2009 |
20090238567 | Electrical Ring Distribution Interface for an Optical Transceiver - A ring connection system and method are provided for distributing signals in an optical-to-electrical interface. The method electrically connects a plurality of nodes in a series-connected ring, and receives an optical signal at a first node from a service provider. The method converts the optical signal to an electrical signal, and distributes the electrical signal via the ring. At each node, the electrical signal is supplied from a customer interface. Typically, each node has a plurality of customer interfaces. In one aspect, ITU-T G.984.3 Giagbit-capable Passive Optical Network (GPON) optical signals are received converted to a customer interface electrical signal such as an Ethernet, asynchronous transfer mode, or time division multiplexed signal. Electrically connecting the plurality of nodes in the series-connected ring includes: series connecting the nodes in a North ring; and, series connecting the nodes in a South ring, opposite in direction from the North ring. | 09-24-2009 |
20140266328 | FREQUENCY SYNTHESIS WITH GAPPER - Systems and methods for frequency synthesis using a gapper. A frequency synthesizer may comprise a gapper, a first integer divider and a Phase Locked Loop (PLL). When a frequency of an output signal is intended to be greater than a corresponding input signal, a factor can be borrowed by the gapper from the first integer divider to generate a rational divide ratio G that is greater 1 in order for the gapper to be capable of performing the division by G. The PLL is capable of multiplying a gapped signal output from the first integer divider and attenuating jitter from the gapped signal. | 09-18-2014 |
20140266339 | METHOD AND APPARATUS FOR GAPPING - Systems and methods for generating gapped signals comprising a Delta Sigma Modulator (DSM) configured to generate gapping control signals used to control gap removal rates of an associated gapping unit. The DSM is configured to generate a gapping control signal based on a value of an overflow resulted from performing adding a first number with a remainder of a stored value modulo a second number. The gap removal rates as well as the gap removal resolutions can be adjusted by selecting appropriate values of the first number, the stored value, and the second number. The gapping resolution can be a portion of a pulse. The first number and the second number may be derived from an intended frequency ratio between a gapped signal and a corresponding input signal. The gapping unit may comprise a gapping circuit or a multi-modulus divider. | 09-18-2014 |
20140314192 | METHOD AND APPARATUS FOR SMOOTHING JITTER GENERATED BY BYTE STUFFING - Systems and methods for smoothing jitter generated by byte stuffing. A frequency synthesizer comprises a smoothing logic coupled with a PLL. The smoothing logic is configured to modify a phase error signal generated by a phase frequency detector into a distributed phase error signal that spread over multiple clock cycles. The distributed phase error signal is used to drive a DCO. The smoothing logic may comprise a ramping logic operable to generate a series of ramping values to substitute a phase difference in the phase error signal. The phase difference may correspond to a stuffing byte. | 10-23-2014 |
20140375364 | FREQUENCY SYNTHESIS WITH GAPPER AND MULTI-MODULUS DIVIDER - Systems and methods for frequency synthesis using a gapper and a multi-modulus divider. A frequency synthesizer may comprise a gapper, a multi-modulus divider and a Phase Locked Loop (PLL). When a frequency of an output signal is intended to be greater than a corresponding input signal, a factor can be borrowed by the gapper from the divider to generate a rational divide ratio G that is greater 1 in order for the gapper to be capable of performing the division by G. The PLL is capable of multiplying a gapped signal output from the first integer divider and attenuating jitter from the gapped signal. | 12-25-2014 |
20150110233 | JITTER MITIGATING PHASE LOCKED LOOP CIRCUIT - Systems and methods for efficient jitter mitigation or removal from a gapped signal. A phase mitigation module is employed to generate discrete correction values for modifying phase error signals detected between a gapped signal and a feedback signal of the PLL. The correction values can be digitally subtracted from the output of a phase frequency detector associated with the PLL. The sequence of correction values can be determined based on phase frequency differences between the input signal and a targeted feedback signal that is free of jitter and has a period equal to an average period of the input signal. An average of the correction values is substantially equal to zero, and an average of the modified phase error signal is substantially equal to zero. | 04-23-2015 |
Vincent P. Walker, Bridgewater, MA US
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20110258856 | Shaving Razors And Shaving Cartridges - A shaving blade unit having a housing with a top surface, a bottom surface, a front edge, a rear edge and a pair of side edges extending between the front edge and the rear edge. The housing has a pair of apertures between the front edge and the rear edge. The pair of apertures extend through the housing from the top surface to the bottom surface. One or more shaving blades are disposed between the front edge and the rear edge. The one or more shaving blades each have a cutting edge. A clip has a pair of legs that extend through the pair of apertures. Each leg is bent about at least a portion of the bottom surface of the housing securing the clip to the housing and retaining the blades on the housing. | 10-27-2011 |
Will Walker, Boston, MA US
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20150145171 | SYSTEMS AND METHODS OF POST-PROCESSING FEATURES FOR ADDITIVE FABRICATION - According to some aspects, a method of additive fabrication wherein a plurality of layers of material are formed on a build platform is provided. The method comprises forming a raft structure in contact with the build platform, the raft structure formed from one or more layers of material and comprising at least one removal pocket adjacent to the build platform and forming additional material in contact with the raft structure. According to some aspects, an additive fabrication apparatus configured to form a plurality of layers of material on a build platform is provided. The apparatus comprises the build platform, and at least one controller configured to form a raft structure in contact with the build platform, the raft structure formed from one or more layers of material and comprising at least one removal pocket adjacent to the build platform, and form additional material in contact with the raft structure. | 05-28-2015 |