Patent application number | Description | Published |
20100221770 | Methods for Detecting and Analyzing N-Glycolylneuraminic Acid (Neu5Gc) In Biological Materials - The present application is in the field of sialic acid chemistry, metabolism and antigenicity. More particularly, the present invention relates to the detection and analysis of the non-human sialic acid, N-glycolylneuraminic acid (Neu5Gc) in biological materials, such as food and clinical specimens. Such detection and analysis is facilitated by the use of Neu5Gc specific antibodies. The present invention also relates to the detection of antiNeu5Gc antibodies in clinical samples, as well as the production of anti-Neu5Gc specific antibodies. | 09-02-2010 |
20100293624 | ELIMINATION OF N-GLUCOLYLNEURAMINIC ACID FROM ANIMAL PRODUCTS FOR HUMAN USE - This application is in the field of sialic acid chemistry, metabolism, antigenicity, and the production of transgenic non-human mammals with altered sialic acid production. More particularly, this application relates to N-glycolylneuraminic acid (Neu5Gc) being an immunogen in humans, and the production of Neu5Gc-free mammalian products for laboratory and human use. | 11-18-2010 |
20110177614 | COMPOSITIONS AND METHODS FOR DETECTING CANCER - The invention provides sialylated glycans and antibodies that specifically bind to them. The invention's compositions and methods for using them are useful for early detection and diagnosis of cancer. | 07-21-2011 |
20110195921 | ELIMINATION OF A CONTAMINATING NON-HUMAN SIALIC ACID BY METABOLIC COMPETITION - The disclosure provides a method of reducing or eliminating Neu5Gc in a cell culture or in a human subject. The method includes flooding the system with the human sialic acid i\7-acetylneuraminic acid (Neu5Ac) in glycosidically-bound or free form, or its precursor N-acetylmannosamine (ManNAc) in an amount sufficient to metabolically compete out the Neu5Gc, either as it enters the cells for the first time or when it recycles from break-down of preexisting cellular molecules. Additionally, Neu5Ac feeding results in reduction of Neu5Gc expression even in some animal cells capable of Neu5Gc production. | 08-11-2011 |
20120045816 | Novel Glycosylated Polypeptides - Provided herein are glycosylated polypeptide compositions with substantially reduced Neu5Gc content. The glycosylated polypeptides compositions with substantially reduced Neu5Gc content can be obtained from cell sources cultured with Neu5Gc competitor or from non-human animal sources fed a diet supplemented with Neu5Gc competitor. Also provided herein are methods of treating a human subject with said compositions. | 02-23-2012 |
20120142903 | Methods For Detecting And Analyzing N-Glycolylneuraminic Acid (NEU5GC) In Biological Materials - The present application is in the field of sialic acid chemistry, metabolism and antigenicity. More particularly, the present invention relates to the detection and analysis of the non-human sialic acid, N-glycolylneuraminic acid (Neu5Gc) in biological materials, such as food and clinical specimens. Such detection and analysis is facilitated by the use of Neu5Gc specific antibodies. The present invention also relates to the detection of antiNeu5Gc antibodies in clinical samples, as well as the production of anti-Neu5Gc specific antibodies. | 06-07-2012 |
20130039991 | Elimination of N-Glycolylneuraminic Acid From Animal Products For Human Use - The application is in the field of transgenic (non-human) organisms, sialic acid chemistry, metabolism and antigenicity. More particularly, the invention is related to a method to produce Neu5Gc-free animals and products therefrom comprising disrupting the CMAH gene and thereby reducing or eliminating Neu5Gc from biological material of non-humans. | 02-14-2013 |
20140044798 | Elimination of N-Glycolylneuraminic Acid From Animal Products For Human Use - The application is in the field of transgenic (non-human) organisms, sialic acid chemistry, metabolism and antigenicity. More particularly, the invention is related to a method to produce Neu5Gc-free animals and products therefrom comprising disrupting the CMAH gene and thereby reducing or eliminating Neu5Gc from biological material of non-humans. | 02-13-2014 |
20140057856 | Compositions and Methods For Enhancing Sialic Acid Levels In Tissue - The invention relates to compositions and methods for increasing sialic acid uptake and/or incorporation into tissue following gastrointestinal ingestion of compositions that contain sialic acid. | 02-27-2014 |
20140113979 | Compositions and Methods for Detecting Cancer - The invention provides sialylated glycans and antibodies that specifically bind to them. The invention's compositions and methods for using them are useful for early detection and diagnosis of cancer. | 04-24-2014 |
20140315829 | Compositions And Methods For Enhancing Sialic Acid Levels In Tissue - The invention relates to compositions and methods for increasing sialic acid uptake and/or incorporation into tissue following gastrointestinal ingestion of compositions that contain sialic acid. | 10-23-2014 |