Mandel
Alexander Mandel, Bruchsal DE
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20090063035 | Method and Apparatus for Path Planning and Distance Calculation - Methods and apparatuses enable generation of a managed space layout model defining permissible pathways for travel through the managed space. Each permissible pathway can be defined as a line segment or an edge bounded by coordinate pairs. Items and locations within the managed space are associated with permissible pathways, which association defines how the items/locations can be reached via travel through the managed space. The information can be saved as a network of nodes, which defines the intersection of the permissible pathways and includes information about the pathways. With the layout model, a path can be determined through the managed space to accomplish work in the managed space. The layout data allows a path distance to be calculated for a given work task that involves travel through the managed space. | 03-05-2009 |
20090063238 | Executed Workload - Methods and apparatuses enable generation of an executed workload electronic record. The executed workload record indicates data related to one or more performance metrics by which performance of a work task is evaluated. One such performance metric is an expected time for completion of the task. Performance of the task can be monitored to determine an actual completion time for the task to compare against an expected completion time. The executed workload record can be used for evaluation of workers. Executed workload records provide centralized, aggregatable information for evaluation purposes. | 03-05-2009 |
Alexander L. Mandel, Vancouver CA
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20140315954 | CYTOTOXIC AND ANTI-MITOTIC COMPOUNDS, AND METHODS OF USING THE SAME - Compounds having cytotoxic and/or anti-mitotic activity are disclosed. The compounds have the following structure (I): | 10-23-2014 |
Alexander Laurence Mandel, Vancouver CA
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20160038606 | CYTOTOXIC AND ANTI-MITOTIC COMPOUNDS, AND METHODS OF USING THE SAME - Compounds having cytotoxic and/or anti-mitotic activity are disclosed. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed. Also disclosed are compositions having the structure: (T)-(L)-D), wherein (T) is a targeting moiety, (L) is an optional linker, and (D) is a compound having cytotoxic and/or anti-mitotic activity. | 02-11-2016 |
20160075735 | CYTOTOXIC AND ANTI-MITOTIC COMPOUNDS, AND METHODS OF USING THE SAME - Compounds having cytotoxic and/or anti-mitotic activity are disclosed. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed. Also disclosed are compositions having the structure: (T)-(L)-(D), wherein (T) is a targeting moiety, (L) is an optional linker, and (D) is a compound having cytotoxic and/or anti-mitotic activity. | 03-17-2016 |
Carl Mandel, Toronto CA
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20110035681 | RELATIONAL PRESENTATION OF COMMUNICATIONS AND APPLICATION FOR TRANSACTION ANALYSIS - The system provides a method of sorting and presenting messages in a way so that the relationship in message threads can be easily observed and related messages can be identified. The system provides a way to view messages and map message threads and inboxes in two and three dimensions so that the content of messages can be easily reviewed and the relationship between messages can be seen and followed. The system is not limited to email messages but can present the relationship between multiple types of communications including emails, instant messages, texts, tweets, bulletin boards, wilds, blogs, voice conversations postings on social networks and other types of communications. In addition, the system allows for the inclusion of transactional information, including financial transactions, physical movement, asset deployment, or other acts or activities that may be related to, or independent of, the communications. | 02-10-2011 |
20110072363 | PRESENTATION AND SORTING OF EMAIL - The system provides a method and process for displaying and sorting messages in a communication system. The system allows multiple folders of messages to be opened simultaneously. The system also displays sent and received messages in the same display when desired. The system includes automatic and/or custom color coding of messages for ease of identification of message types, sent or received messages, root sender, cc messages, responsive messages, etc. The system also includes a unique navigation system to allow the user to more easily move through related messages, threads, and folders. The navigation system can be used in situations where the prior art would have required a search to be executed. | 03-24-2011 |
20120191779 | Bulletin Board Data Mapping and Presentation - The system provides a method and apparatus for sorting and displaying information from a BBS. The system provides a method of sorting and presenting messages from a BBS in a way so that the relationship in message threads can be easily observed and related messages can be identified. The system provides a way to view messages and map message threads in two and three dimensions so that the content of messages can be easily reviewed and the relationship between messages can be seen and followed. The system allows a user to enter into a message thread at any point and to then produce a visualization of the related threads and messages associated with each individual message. The system provides interfaces for either a linear or threaded BBS or even a hybrid BBS that is some combination of linear and threaded. | 07-26-2012 |
20120197871 | METHOD AND APPARATUS FOR COLLECTION, DISPLAY AND ANALYSIS OF DISPARATE DATA - The system provides a method and apparatus for sorting and displaying collections of communications. These communications can be a single type or multiple types of data and may come from email systems, bulletin boards, text messages, Facebook and Twitter postings and comments, financial transactions, travel itineraries or any other type of communications. The communications represented by the system can be electronic or physical as desired. The system can also present forwarded, copied, replied, or other types of communications. In one embodiment, the system provides a Universe View of a set of communications. The Universe View, in one embodiment, is a three dimensional representation of a plurality of cubes. Each cube represents a subset of a collection of communications. Each cube can be color coded or shaded to represent a dominant theme of the contents of the communications represented by the cube. | 08-02-2012 |
20120200567 | METHOD AND APPARATUS FOR 3D DISPLAY AND ANALYSIS OF DISPARATE DATA - The system provides a method and apparatus for sorting and displaying collections of communications. These communications can be a single type or multiple types of data and may come from email systems, bulletin boards, text messages, Facebook and Twitter postings and comments, financial transactions, travel itineraries or any other type of communications. The communications represented by the system can be electronic or physical as desired. The system can also present forwarded, copied, replied, or other types of communications. In one embodiment, the system provides a Universe View of a set of communications. The Universe View, in one embodiment, is a three dimensional representation of a plurality of cubes. Each cube represents a subset of a collection of communications. Each cube can be color coded or shaded to represent a dominant theme of the contents of the communications represented by the cube. | 08-09-2012 |
20140122467 | METHOD AND APPARATUS FOR COLLECTION, DISPLAY AND ANALYSIS OF DISPARATE DATA - The system provides a method and apparatus for sorting and displaying collections of communications. These communications can be a single type or multiple types of data and may come from email systems, bulletin boards, text messages, Facebook and Twitter postings and comments, financial transactions, travel itineraries or any other type of communications. The communications represented by the system can be electronic or physical as desired. The system can also present forwarded, copied, replied, or other types of communications. In one embodiment, the system provides a Universe View of a set of communications. The Universe View, in one embodiment, is a three dimensional representation of a plurality of cubes. Each cube represents a subset of a collection of communications. Each cube can be color coded or shaded to represent a dominant theme of the contents of the communications represented by the cube. | 05-01-2014 |
20150347596 | Bulletin Board Data Mapping and Presentation - The system provides a method and apparatus for sorting and displaying information from a BBS. The system provides a method of sorting and presenting messages from a BBS in a way so that the relationship in message threads can be easily observed and related messages can be identified. The system provides a way to view messages and map message threads in two and three dimensions so that the content of messages can be easily reviewed and the relationship between messages can be seen and followed. The system allows a user to enter into a message thread at any point and to then produce a visualization of the related threads and messages associated with each individual message. The system provides interfaces for either a linear or threaded BBS or even a hybrid BBS that is some combination of linear and threaded. | 12-03-2015 |
David Mandel, Toronto CA
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20140122467 | METHOD AND APPARATUS FOR COLLECTION, DISPLAY AND ANALYSIS OF DISPARATE DATA - The system provides a method and apparatus for sorting and displaying collections of communications. These communications can be a single type or multiple types of data and may come from email systems, bulletin boards, text messages, Facebook and Twitter postings and comments, financial transactions, travel itineraries or any other type of communications. The communications represented by the system can be electronic or physical as desired. The system can also present forwarded, copied, replied, or other types of communications. In one embodiment, the system provides a Universe View of a set of communications. The Universe View, in one embodiment, is a three dimensional representation of a plurality of cubes. Each cube represents a subset of a collection of communications. Each cube can be color coded or shaded to represent a dominant theme of the contents of the communications represented by the cube. | 05-01-2014 |
20150347596 | Bulletin Board Data Mapping and Presentation - The system provides a method and apparatus for sorting and displaying information from a BBS. The system provides a method of sorting and presenting messages from a BBS in a way so that the relationship in message threads can be easily observed and related messages can be identified. The system provides a way to view messages and map message threads in two and three dimensions so that the content of messages can be easily reviewed and the relationship between messages can be seen and followed. The system allows a user to enter into a message thread at any point and to then produce a visualization of the related threads and messages associated with each individual message. The system provides interfaces for either a linear or threaded BBS or even a hybrid BBS that is some combination of linear and threaded. | 12-03-2015 |
David Mandel, Los Angeles CA
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20120197871 | METHOD AND APPARATUS FOR COLLECTION, DISPLAY AND ANALYSIS OF DISPARATE DATA - The system provides a method and apparatus for sorting and displaying collections of communications. These communications can be a single type or multiple types of data and may come from email systems, bulletin boards, text messages, Facebook and Twitter postings and comments, financial transactions, travel itineraries or any other type of communications. The communications represented by the system can be electronic or physical as desired. The system can also present forwarded, copied, replied, or other types of communications. In one embodiment, the system provides a Universe View of a set of communications. The Universe View, in one embodiment, is a three dimensional representation of a plurality of cubes. Each cube represents a subset of a collection of communications. Each cube can be color coded or shaded to represent a dominant theme of the contents of the communications represented by the cube. | 08-02-2012 |
Eric Mandel, St Quentin FR
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20150314358 | METHOD OF ASSEMBLY USING MAGNETIC CRIMPING - A method of assembling a first part ( | 11-05-2015 |
Harald Mandel, Leinfelden-Echterdingen DE
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20080284151 | Collision-Protected Front Frame Structure of a Truck - A front frame structure of a truck with upper longitudinal members and with lower longitudinal member elements which are connected to one another via vertical frame struts is provided. The lower longitudinal member elements are designed at least in some regions as collision-force-absorbing deformation bodies and are completely integrated into the frame structure. | 11-20-2008 |
Ilana Mandel, Kiryat Yam IL
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20140271618 | ANTIBODIES TO CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE (CEACAM) - The present invention provides antibodies, as well as molecules having at least the antigen-binding portion of an antibody, recognizing a specific epitope of the protein CEACAM1 and optionally binds also other subtypes of the CEACAM protein family. Disclosed antibodies and antibody fragments are characterized by specific CDR sequences. Methods of production and use in therapy and diagnosis, of such antibodies and antibody fragments are also provided. | 09-18-2014 |
Jean-Louis Mandel, Schiltigheim FR
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20100130429 | BBS10 RELATED DIAGNOSTIC METHODS AND REAGENTS FOR BARDET-BIEDL SYNDROME - The present invention relates to the identification of a gene, designated BBS1O, that is involved in the genetic disease Bardet Biedl Syndrome (BBS), which is characterized by such diverse symptoms as obesity, diabetes, hypertension, mental retardation, renal cancer and other abnormalities, retinopathy and hypogonadism. Methods of use for the gene, for example in diagnosis and therapy of BBS, also are described. | 05-27-2010 |
Jörg Mandel, Stuttgart DE
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20100185553 | METHOD AND SYSTEM FOR MARKING OBJECTS - In a method and system for marking objects which pass through different process stages, the objects are described ontologically for the respective process stages, and classes and/or relations for marking the objects as equivalents are linked to one another. | 07-22-2010 |
Jörg Mandel, Stuttgart DE
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20100185553 | METHOD AND SYSTEM FOR MARKING OBJECTS - In a method and system for marking objects which pass through different process stages, the objects are described ontologically for the respective process stages, and classes and/or relations for marking the objects as equivalents are linked to one another. | 07-22-2010 |
Karl Mandel, Prem DE
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20150217288 | Particle for Recovering an Anion from an Aqueous Solution - The invention concerns a particle for recovering an anion from an aqueous solution comprising a magnetic material associated with a silica based layer forming a magnetic microparticle with a silica based surface, and a layered double hydroxide deposited on the surface of the microparticle. The invention further concerns a method for manufacturing a magnetic particle comprising mixing a magnetic microparticle with a silica based surface in an aqueous solution at about pH 7 with a dispersion of layered double hydroxide at about pH 7 to obtain a mixture, and ultrasonicating the mixture for depositing the layered double hydroxide on the surface of the microparticle. In addition, the invention concerns various uses of the particle. | 08-06-2015 |
Kostia Mandel, Netanya IL
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20080220694 | CENTERLESS FEED-THROUGH SUPER-FINISHING DEVICE HAVING A LAPPING SYSTEM CONTAINING A FREELY-DISPOSED ABRASIVE - A centerless feed-through super-finishing device including: first and second feed-through rollers having first and second longitudinal outer surfaces; a metallic part having a generally cylindrical section, disposed between the outer surfaces, wherein a longitudinal axis of the cylindrical section is generally aligned with the outer surfaces, the cylindrical section having a metal working surface, the outer surfaces disposed in a near-parallel fashion; a rotating mechanism for rotation of the rollers along respective longitudinal axes thereof, and for effecting thereby a rotation of the cylindrical section, wherein an angle between the rollers is selected such that rotation of the rollers propels the cylindrical section between the rollers; and a lapping system including: a lapping tool having a polymeric contact surface disposed to contact the working surface, and a lapping mechanism, associated with the lapping tool, adapted to exert a load on the contact and working surfaces; and abrasive particles, freely disposed between the contact and working surfaces, wherein the contact surface and the lapping mechanism are adapted, and the abrasive particles are selected, such that the relative motion under the load effects lapping of the working surface, and wherein the surfaces of the rollers are covered with a polymeric material. | 09-11-2008 |
20080227372 | TRIBOLOGICAL SURFACE AND LAPPING METHOD AND SYSTEM THEREFOR - A tribological system including: a tribological workpiece having a working surface adapted for moving relative to a counter-surface in a presence of a lubricant, in a load-bearing environment, the working surface for disposing generally opposite the counter-surface, the working surface having: (i) a metal surface layer; (ii) a plurality of organic particles incorporated in the metal surface layer, and (iii) a plurality of inorganic particles incorporated in the working surface, the inorganic particles having a Mohs hardness of at least 8. | 09-18-2008 |
20080311825 | Incorporation of Particulate Additives Into Metal Working Surfaces - A mechanical device and method for lapping a metal working surface, the device including: (a) a workpiece having the metal working surface; (b) a contact surface, disposed generally opposite the working surface, for moving in a relative motion to the working surface; (c) a plurality of abrasive particles, disposed between the contact surface and the working surface, and (d) a mechanism, associated with at least one of the surfaces, for applying the relative motion, and for exerting a load on the contact surface and the working surface, the contact surface for providing an at least partially elastic interaction with the abrasive particles, wherein, associated with the contact surface is a particulate additive material, and wherein, upon activation of the mechanism, the relative motion under the load causes a portion of the abrasive particles to lap the working surface, and wherein the relative motion under the load effects incorporation of a portion of the particulate additive material into the working surface. | 12-18-2008 |
20150231757 | MULTIPLE-PHASE SURFACES, AND METHOD THEREFOR - A workpiece having a multiple-phase working surface, and a lapping process for producing the surface, the process including: (a) providing a system including: (i) a workpiece having a multiple-phase working surface having a first continuous solid phase, and a second solid phase, intimately dispersed within the continuous phase in the multiple-phase working surface, she continuous phase having a hastiness exceeding a hardness of the second phase by a Mohs Hardness of at least 0.5; (ii) a contact surface, disposed generally opposite the working surface, having a Shore D hardness within a range of 40-90, and a Young's modulus of less than 20 gigapascels; (iii) a plurality of abrasive particles, freely disposed between the contact and working surfaces, and (b) lapping the working surface by exerting a pressure on the surfaces and applying a relative motion between the surfaces, to effect an elastic interaction between the contact surface and the abrasive particles in which at least a portion of the abrasive particles penetrate the working surface, to produce a lapped product having a modified working surface, in which an exterior surface of the second phase is recessed by an average of at least 1.5 micrometers with respect to an exterior surface of the continuous phase. | 08-20-2015 |
Moshe Mandel, Doar Afek IL
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20090018499 | Inflation/deflation system for a catheter - According to the present invention there is provided an inflation/deflation system for a dilatation balloon comprising a receptacle, a pressure member, a sensing system and a data processing and display unit. The receptacle is adapted to contain an inflation fluid to be introduced into the balloon during its inflation. The receptacle also has an inlet/outlet port adapted for connection to the dilatation balloon; The pressure member is adapted to be axially displaced within the receptacle to cause the fluid to exit the receptacle via the outlet port. The sensing system comprises a first sensor and a second sensor. The first sensor is associated with the pressure member to sense its axial displacement. The second sensor is associated with the interior of the receptacle to sense in a non-contact manner the pressure P of the inflation fluid within the receptacle, and to provide a corresponding data signal. The data processing and display unit is adapted to process the signal and display at least a scheme of pressure P within the receptacle vs. the volume V of the inflation fluid exiting the receptacle through the inlet/outlet port. The volume is calculated by the axial displacement of the pressure member. The scheme reflects the corresponding P-V conditions within the balloon when the system is in use. | 01-15-2009 |
Oliver Mandel, Baienfurt DE
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20160139253 | Signal acquisition and distance variation measurement system for laser ranging interferometers - A signal acquisition and distance variation measurement system for laser ranging interferometers comprising a signal acquisition unit. This unit comprises a frequency detection subsystem to detect the frequency of a received laser beam measurement signal which is buried in noise, wherein the subsystem comprises an acquisition subsystem with a wavelet packet decomposition unit and a phase/frequency detector PLL; a main PLL unit being coupled to the frequency detection subsystem for receiving the detected frequency of the measurement signal for phase estimation of the measurement signal; and a phasemeter band detection subsystem for detecting whether the measurement signal frequency is higher or lower than a reference signal frequency of a reference laser beam by operating a known change to the frequency of the reference signal and measuring the consequent change in the frequency of an interference signal for having the phase of reference signal locked to the measurement signal phase. | 05-19-2016 |
Rina Mandel, Netanya IL
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20110111676 | MULTIPLE-PHASE SURFACES, AND METHOD THEREFOR - A workpiece having a multiple-phase working surface, and a lapping process for producing the surface, the process including: (a) providing a system including: (i) a workpiece having a multiple-phase working surface having a first continuous solid phase, and a second solid phase, intimately dispersed within the continuous phase in the multiple-phase working surface, the continuous phase having a hardness exceeding a hardness of the second phase by a Mohs Hardness of at least 0.5; (ii) a contact surface, disposed generally opposite the working surface, having a Shore D hardness within a range of 40-90, and a Young's modulus of less than 20 gigapascals; (iii) a plurality of abrasive particles, freely disposed between the contact and working surfaces, and (b) lapping the working surface by exerting a pressure on the surfaces and applying a relative motion between the surfaces, to effect an elastic interaction between the contact surface and the abrasive particles in which at least a portion of the abrasive particles penetrate the working surface, to produce a lapped product having a modified working surface, in which an exterior surface of the second phase is recessed by an average of at least 1.5 micrometers with respect to an exterior surface of the continuous phase. | 05-12-2011 |
Robin Mandel, Paris FR
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20130258583 | COMPOSITE MATERIAL FADEC BOX SUPPORT - A device for protecting a computer of an aircraft turbine engine, the device comprising a box containing the computer and a cover covering the box, the box being supported by tabs forming integral portions of the box and maintaining a flow of air between the bottom of the box and a portion of the casing of the engine on which they are to come into secure contact via resilient studs, the box being made of a composite material. | 10-03-2013 |
20150021455 | TURBINE ENGINE SUPPORT PART OF HYBRID STRUCTURE - A turbine engine support part including a main structure made of composite material and a reinforcing secondary structure made of metal and integrated in the main structure, the secondary structure presenting a geometrical shape and dimensions configured to impart mechanical strength to the support part in event of the main structure being destroyed. | 01-22-2015 |
20160114884 | METHOD OF FABRICATING A FORCE TRANSFER PART HAVING A LUG MADE OF COMPOSITE MATERIAL, AND A PART OBTAINED BY SUCH A METHOD - The invention provides a method of fabricating a force transfer part ( | 04-28-2016 |
Roland Mandel, Lindau DE
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20130082084 | DRIVING DEVICE - According to one aspect of the application, a tool for driving a fastening element into an underlying surface comprises an energy transmission element for transmitting energy to the fastening element. The energy transmission element is preferably movable between an initial position and a setting position, the energy transmission element being situated in the initial position before the driving process and in the setting position after the driving process. | 04-04-2013 |
20150209947 | DRIVE-IN DEVICE HAVING AN EFFECTIVE DRIVE - The invention relates to a drive-in device, comprising a handheld housing ( | 07-30-2015 |
20150283690 | HAND-HELD OR SEMI-STATIONARY TOOL APPLIANCE AND METHOD FOR OPERATING A TOOL APPLIANCE OF THIS KIND - The invention relates to a handheld or semi-stationary tool appliance ( | 10-08-2015 |
Ron Mandel, Haifa IL
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20120047108 | POINT-IN-TIME (PIT) BASED THIN RECLAMATION SUPPORT FOR SYSTEMS WITH A STORAGE USAGE MAP API - A method, a system and/or and an apparatus to minimize data loss by de-allocating storage space with the help of an Application Programming Interface (API). In one embodiment, the method includes reclaiming data storage in a storage device slated as a reclamation target by redirecting write commands intended for the reclamation target to a point-in-time volume of the reclamation target; generating a list of portions of storage from the reclamation target such that each portion of storage has an API state of unused as per a system that uses the storage device; and includes converting a reclamation state associated with each of the portions of storage to a state of ‘unused’. In addition, the method involves synchronization of the point-in-time volume with the reclamation target to capture any changes that might be associated with the point-in-time volume. | 02-23-2012 |
20120117320 | LATENCY REDUCTION ASSOCIATED WITH A RESPONSE TO A REQUEST IN A STORAGE SYSTEM - A method includes segmenting a virtual volume into an active area configured to map to a first type of storage and a non-active area configured to map to a second type of storage through a storage virtualization engine. The second type of storage includes data associated with a host device and the first type of storage includes point-in-time images corresponding to the data associated with the host device. The first type of storage offers a higher performance than that of the second type of storage. The method also includes allocating a portion of space in the first type of storage to serve as a cache memory during a write operation and/or a read operation, and reducing a latency associated with the response to a write request and/or a read request through performing the corresponding write operation and/or the read operation through the first type of storage. | 05-10-2012 |
Shahar Even-Dar Mandel, Tel Aviv IL
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20130060139 | METHOD OF DETECTING PORTAL AND/OR HEPATIC PRESSURE AND A PORTAL HYPERTENSION MONITORING SYSTEM - The devices and methods generally relate to vibratable sensors for measuring ambient fluid pressure, in particular implantable sensors. The devices and methods are particularly well-suited to implantation within the body of a living animal or human to monitor physiological conditions, such as portal and/or hepatic venous blood pressure, and allow frequent, remote interrogation of venous pressure using the resonance frequency of an implanted sensor. The sensor devices are relatively small compared to conventional devices for measuring fluid pressure and can be implanted in the porto-hepatic venous system, whereas conventional devices are too large. The small size of the device is accomplished by using a thick sensor membrane, compared to conventional devices, and by limiting the size of additional elements of the device relative to the size of the sensor membrane. The thicker sensor member also obviates the need for multiple sensor arrays and maintains the accuracy and robustness of the sensor device. A data capture, processing, and display system provides a pressure measurement reading, and is particularly well-suited for detecting portal hypertension in patients with liver disorders. | 03-07-2013 |
Shay Mandel, Kiryat Ono IL
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20140096025 | INTEGRATED EXPERIENCE FOR APPLICATIONS WITHIN A MOBILE APPLICATION - A system and method that supports an integrated user interface experience with third party hosted applications selected and installed by a user within a user-installed native application of a user communication device. | 04-03-2014 |
Silva A. Mandel, Haifa IL
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20130217028 | PERIPHERAL BLOOD GENE MARKERS FOR EARLY DIAGNOSIS OF PARKINSON'S DISEASE - The present invention relates to the use of molecular risk marker profiles for diagnosis of Parkinson's disease. More particularly, the invention provides methods for diagnosis of Parkinson's disease in an individual, utilizing certain profiles established based on the expression levels of certain genes, which together form a gene panel, in the peripheral blood of said individual, as well as kits for carrying out these methods. The profile encompass ALDH1A1. | 08-22-2013 |
Silvia Mandel, Haifa IL
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20110098262 | CORROLES FOR NEUROPROTECTION AND NEURORESCUE - Transition metal complexes of amphiphilic corroles, optical isomers and pharmaceutically acceptable salts thereof are useful for neuroprotection and neurorescue, particularly for treatment of diabetes and neurodegenerative diseases. The amphiphilic corrole is preferably a 5,10,15-tris-aryl- or 5,10,15-tris-CF | 04-28-2011 |
20140045809 | CORROLES FOR NEUROPROTECTION AND NEURORESCUE - Transition metal complexes of amphiphilic corroles, optical isomers and pharmaceutically acceptable salts thereof are useful for neuroprotection and neurorescue, particularly for treatment of diabetes and neurodegenerative diseases. The amphiphilic corrole is preferably a 5,10,15-tris-aryl- or 5,10,15-tris-CF | 02-13-2014 |
Silvia A. Mandel, Haifa IL
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20100221735 | DIAGNOSTIC TEST FOR PARKINSON'S DISEASE - The present invention relates to molecular markers for detection, prognosis and follow up of Parkinson's disease (PD), wherein said molecular markers are one or more genes with altered expression pattern, or gene products thereof (RNA or protein). Genes which expression is upregulated or downregulated in PD patients are tools for early diagnosis od PD, for monitoring the progress of the disease and can serve as targets for screening new agents for treatment of PD. | 09-02-2010 |
Tali Mandel, Rehovot IL
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20110093986 | TOMATO SIMYB12 TRANSCRIPTION FACTOR AND GENETIC SELECTION THEREOF - The present invention discloses that down regulation of the SlMYB12 transcription factor results in the colorless peel y phenotype in tomato fruit. The present invention provides polynucleotides encoding the tomato SlMYB12 transcription factor and genetic markers derived therefrom, useful in the breeding of tomato plants having the colorless peel phenotype and in the production of transgenic plants having altered flavonoid content. | 04-21-2011 |
Tiiu Mandel, Tartu EE
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20110076760 | Viral expression plasmids for production of proteins, antibodies, enzymes, virus-like particles and for use in cell-based assays - This disclosure shows that the EBV FR-element comprised of EBNA1 multimeric binding sites can provide the stable maintenance replication function to the mouse polyomavirus (PyV) core origin plasmids in the presence of BPV-1 E2 protein and PyV large T-antigen (LT). | 03-31-2011 |
20130236958 | Viral expression plasmids for production of proteins, antibodies, enzymes, virus-like particles and for use in cell-based assays - This disclosure shows that the EBV FR-element comprised of EBNA1 multimeric binding sites can provide the stable maintenance replication function to the mouse polyomavirus (PyV) core origin plasmids in the presence of BPV-1 E2 protein and PyV large T-antigen (LT). | 09-12-2013 |
Ulla Mandel, Holte DK
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20140005366 | GENERATION OF A CANCER-SPECIFIC IMMUNE RESPONSE TOWARD MUC1 AND CANCER SPECIFIC MUC1 ANTIBODIES | 01-02-2014 |
20150065692 | GENERATION OF A CANCER-SPECIFIC IMMUNE RESPONSE TOWARD MUC1 AND CANCER SPECIFIC MUC1 ANTIBODIES - The present invention provides a method for inducing a cancer specific immune response against MUC1 using an immunogenic glycopeptide. Other aspects of the invention are a pharmaceutical composition comprising the immunogenic glycopeptide and a cancer vaccine comprising the immunogenic glycopeptide. Another aspect is an antibody generated using the immunogenic glycopeptide and the use of said antibody in therapy and diagnosis. | 03-05-2015 |
Ulla Mandel, Holte GB
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20100034825 | GENERATION OF A CANCER-SPECIFIC IMMUNE RESPONSE TOWARD MUC1 AND CANCER SPECIFIC MUC1 ANTIBODIES - The present invention provides a method for inducing a cancer specific immune response against MUC1 using an immunogenic glycopeptide. Other aspects of the invention are a pharmaceutical composition comprising the immunogenic glycopeptide and a cancer vaccine comprising the immunogenic glycopeptide. Another aspect is an antibody generated using the immunogenic glycopeptide and the use of said antibody in therapy and diagnosis. | 02-11-2010 |
Ulta Mandel, Holte DK
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20130059744 | METHOD FOR EARLY DETECTION OF CANCER - The present inventors have demonstrated that circulating auto-antibodies to cancer antigens hold promise as specific and sensitive biomarkers for the early detection of cancer. The present invention thus relates to methods of detecting cancer in a sample, comprising utilising a glycopeptide bait derived from human mucins with different cancer-associated O-glycans. Detected antibodies were demonstrated as glycopeptide specific, and it could be discriminated between e.g. colorectal cancer patients and healthy individuals. The inventors have also developed monoclonal antibodies based on the identified glycopeptides epitope baits, and demonstrated differential expression of the relevant target antigens. The invention thus, in a lock and key-based manner includes both glycopeptides and antibody tools for early detection of cancer, as well as methods of using the same for in situ visualisation and treatment of specific cancer types. | 03-07-2013 |
Zak Mandel, Vaughan CA
Patent application number | Description | Published |
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20150347209 | SYSTEM AND METHOD FOR APPLICATION INACTIVITY CONTROL - A system includes multiple applications executing on a device. One or more user-interfaces connect with the device. The one or more user-interfaces interact with the applications as user-interface activities. A processor sends or receives an indication of the user-interface activities for the multiple applications. The multiple applications are closed or locked, or the device logged out, based on the indication of the user-interface activities for the multiple applications. | 12-03-2015 |
20150350338 | SYSTEM AND METHOD FOR SINGLE LOGOUT OF APPLICATIONS - A system includes an activity manager connected with a device, an application server and an identity provider. The activity manager clears a device session with both the identity provider and the application server to logout applications provided by the application server to the device. | 12-03-2015 |
Zak Mandel, Nesher IL
Patent application number | Description | Published |
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20110131144 | SOCIAL ANALYSIS IN MULTI-PARTICIPANT MEETINGS - A method, system and computer program product are provided for social analysis in multi-party meetings. The method includes receiving a data stream of a multi-participant meeting and identifying participants' contributions in the data stream. The method also includes detecting a sub-activity within the data stream in which two or more participants are active and calculating a connection weight between two participants based on contributions in a sub-activity. Calculating a connection weight between two participants includes increasing a weighting of two participants that interact in the same sub-activity. The method also includes integrating the connection weight between two participants into a weighted social network. | 06-02-2011 |
20120233257 | SOCIAL ANALYSIS IN MULTI-PARTICIPANT MEETINGS - Methods and systems for social analysis in multi-participant meetings provide for receiving a data stream of a multi-participant meeting, wherein multiple topics are discussed. The data stream is analyzed to detect topics and to define topical sub-activities that are performed by at least a portion of the participants. Contributions to a topic by two of the participants in the topical sub-activities are identified and evaluated. A connection weight between the two participants is calculated based on the evaluation of their respective contributions. | 09-13-2012 |
20130019121 | Synchronization of Data Streams with Associated Metadata StreamsAANM Ben-David; ShayAACI HaifaAACO ILAAGP Ben-David; Shay Haifa ILAANM Hazanovich; EvgenyAACI HaifaAACO ILAAGP Hazanovich; Evgeny Haifa ILAANM Mandel; ZakAACI NesherAACO ILAAGP Mandel; Zak Nesher IL - Synchronizing a data stream with an associated metadata stream by receiving a data stream and a metadata stream having a plurality of metadata events associated with the data stream, identifying within the data stream a plurality of data events, matching each of the data events to one of the metadata events in accordance with a matching criterion, and synchronizing the data stream with the metadata stream by effecting a relative time shift between the metadata stream and the data stream in accordance with a time shift adjustment value that results in the smallest sum of absolute differences between time indices of each matched data event and metadata event. | 01-17-2013 |
20130254299 | SENDER FEEDBACK ON EMAIL CORRESPONDENCE - Method, system, and computer program product for sender feedback on email correspondence are provided. The method performed at an email client or server includes: activating a feedback service; receiving one or more emails; generating a feedback request to an email sender; receiving a response to the feedback request providing feedback; and handling an email in accordance with the received feedback. The method may also include filtering received emails to determine if a feedback request is to be sent. If the feedback indicates that an email is no longer relevant, the handling step may include deleting or marking the email accordingly. | 09-26-2013 |