Patent application number | Description | Published |
20080317760 | Compositions and Methods for Diagnosing and Treating Cancer - Monoclonal antibodies that specifically bind to an extracellular domain of human Jagged 1 and inhibit growth of a tumor comprising cancer stem cells are described. Also described is a method of treating cancer that comprises administering a therapeutically effective amount of a monoclonal anti-Jagged 1 antibody. | 12-25-2008 |
20090047285 | Compositions and methods for diagnosing and treating cancer - Isolated antibodies that specifically binds to an extracellular conserved ligand binding region of a human Notch receptor and inhibits growth of a tumor are described. Also described are methods of treating cancer, the method comprising administering an anti-Notch antibody in an amount effective to inhibit tumor growth. | 02-19-2009 |
20100111958 | Notch-Binding Agents and Antagonists and Methods of Use Thereof - The present invention relates to Notch-binding agents and Notch antagonists and methods of using the agents and/or antagonists for treating diseases such as cancer. The present invention provides antibodies that specifically bind to a non-ligand binding region of the extracellular domain of one or more human Notch receptor, such as Notch2 and/or Notch3, and inhibit tumor growth. The present invention further provides methods of treating cancer, the methods comprising administering a therapeutically effective amount of an antibody that specifically binds to a non-ligand binding region of the extracellular domain of a human Notch receptor protein and inhibits tumor growth. | 05-06-2010 |
20110311552 | NOTCH1 RECEPTOR BINDING AGENTS AND METHODS OF USE THEREOF - Means and methods for the diagnosis, characterization, prognosis and treatment of cancer, specifically targeting cancer stem cells are disclosed Provided is an antibody that specifically binds to a non-ligand binding membrane proximal region of the extracellular domain of a human Notch receptor and inhibits tumor growth, and a method of treating cancer comprising administering said antibody to a subject. | 12-22-2011 |
20120288496 | Notch-Binding Agents and Antagonists and Methods of Use Thereof - The present invention relates to Notch-binding agents and Notch antagonists and methods of using the agents and/or antagonists for treating diseases such as cancer. The present invention provides antibodies that specifically bind to a non-ligand binding region of the extracellular domain of one or more human Notch receptor, such as Notch2 and/or Notch3, and inhibit tumor growth. The present invention further provides methods of treating cancer, the methods comprising administering a therapeutically effective amount of an antibody that specifically binds to a non-ligand binding region of the extracellular domain of a human Notch receptor protein and inhibits tumor growth. | 11-15-2012 |
20120308558 | Methods of Using Antibodies That Bind The Glutamate Ligand Binding Region of Notch1 - Isolated antibodies that specifically binds to an extracellular conserved ligand binding region of a human Notch receptor and inhibits growth of a tumor are described. Also described are methods of treating cancer, the method comprising administering an anti-Notch antibody in an amount effective to inhibit tumor growth. | 12-06-2012 |
20130243774 | NOTCH1 BINDING AGENTS AND METHODS OF USE THEREOF - The present invention relates to Notch1 binding agents and methods of using the agents for treating diseases, such as hematologic cancers. The present invention provides antibodies that specifically bind to a non-ligand binding membrane proximal region of the extracellular domain of human Notch1. The present invention further provides methods of using agents that inhibit Notch1 activity for treating cancer. Also described are methods of treating hematologic cancers comprising administering a therapeutically effective amount of a binding agent or antibody of the present invention to a subject having a hematologic cancer such as T-cell lymphoblastic leukemia. | 09-19-2013 |
20130260455 | NOTCH BINDING AGENTS AND ANTAGONISTS AND METHODS OF USE THEREOF - The present invention relates to Notch-binding agents and Notch antagonists and methods of using the agents and/or antagonists for treating diseases such as cancer. The present invention provides antibodies that specifically bind to a non-ligand binding region of the extracellular domain of one or more human Notch receptor, such as Notch2 and/or Notch3, and inhibit tumor growth. The present invention further provides methods of treating cancer, the methods comprising administering a therapeutically effective amount of an antibody that specifically binds to a non-ligand binding region of the extracellular domain of a human Notch receptor protein and inhibits tumor growth. | 10-03-2013 |
20130280277 | NOTCH1 RECEPTOR BINDING AGENTS AND METHODS OF USE THEREOF - The present invention relates to compositions and methods for characterizing, diagnosing, and treating cancer. In particular the invention provides the means and methods for the diagnosis, characterization, prognosis and treatment of cancer and specifically targeting cancer stem cells. The present invention provides an antibody that specifically binds to a non-ligand binding membrane proximal region of the extracellular domain of a human Notch receptor and inhibits tumor growth. The present invention further provides a method of treating cancer, the method comprising administering a therapeutically effective amount of an antibody that specifically binds to a non-ligand binding membrane proximal region of the extracellular domain of a human Notch receptor protein and inhibits tumor growth. | 10-24-2013 |
20130296536 | NOTCH BINDING AGENTS AND ANTAGONISTS AND METHODS OF USE THEREOF - The present invention relates to Notch-binding agents and Notch antagonists and methods of using the agents and/or antagonists for treating diseases such as cancer. The present invention provides antibodies that specifically bind to a non-ligand binding region of the extracellular domain of one or more human Notch receptor, such as Notch2 and/or Notch3, and inhibit tumor growth. The present invention further provides methods of treating cancer, the methods comprising administering a therapeutically effective amount of an antibody that specifically binds to a non-ligand binding region of the extracellular domain of a human Notch receptor protein and inhibits tumor growth. | 11-07-2013 |
20130323257 | ANTIBODIES THAT BIND THE GLUTAMATE LIGAND BINDING REGION OF NOTCH3 - Isolated antibodies that specifically binds to an extracellular conserved ligand binding region of a human Notch receptor and inhibits growth of a tumor are described. Also described are methods of treating cancer, the method comprising administering an anti-Notch antibody in an amount effective to inhibit tumor growth. | 12-05-2013 |
Patent application number | Description | Published |
20120296295 | FEMININE HYGIENE ABSORBENT ARTICLE COMPRISING A SUPERABSORBENT FOAM OF HIGH SWELL RATE - This invention relates to a feminine hygiene absorbent article comprising superabsorbent foams obtainable by foaming an aqueous mixture comprising at least one monoethylenically unsaturated monomer bearing acid groups, at least one blowing agent, at least one crosslinker and at least one surfactant, polymerizing the foamed mixture and drying the polymerized mixture, to the foams and also to their use for absorbing aqueous fluids. | 11-22-2012 |
20120296296 | FEMININE HYGIENE ABSORBENT ARTICLES COMPRISING WATER-ABSORBING COMPOSITES - This invention relates to a feminine hygiene absorbent article comprising water-absorbing composites obtainable by foaming an aqueous mixture comprising at least one monoethylenically unsaturated monomer bearing acid groups, at least one crosslinker, at least one initiator and at least one surfactant, contacting the foam obtained with at least one web of synthetic fibers and polymerizing, to the composites themselves and to their use for absorbing aqueous fluids. | 11-22-2012 |
20130207037 | Water-Absorbing Polymeric Particles and Method for the Production Thereof - The present invention relates to a water-absorbing material obtainable by a process comprising the steps of: a) obtaining, optionally coated, post-crosslinked water-absorbing polymeric particles; b) exposing said particles of step a) to a vacuum-treatment, at a pressure of from 0.0001 mbar to 700 mbar; and c) optionally exposing said particles of step b) to a plasma-treatment, and processes for their production. | 08-15-2013 |
20140047730 | METHOD FOR THE PRODUCTION OF WATER ABSORBING POLYMERS - A process for producing a water-absorbing polymer by polymerizing a monomer solution and drying the resulting hydrogel by means of a heated gas stream comprises
| 02-20-2014 |
20140158626 | WATER-ABSORBING COMPOSITES - This invention relates to a process for producing water-absorbing composites comprising the steps of foaming an aqueous mixture comprising at least one monoethylenically unsaturated monomer bearing acid groups, at least one crosslinker, at least one initiator and at least one surfactant, contacting the foam obtained with at least one web of synthetic fibers and polymerizing, to the composites themselves and to their use for absorbing aqueous fluids. | 06-12-2014 |