Bernstein, MA
Bradley E. Bernstein, Cambridge, MA US
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20110189677 | Methods For Preparing Sequencing Libraries - Improvements in chromatin immunoprecipitation-high throughput sequencing techniques has allowed the creation of chromatin maps from limited biological sample sizes that cannot be evaluated using conventional chromatin immunoprecipitation-sequencing protocols. For example, a modified universal primer is utilized that incorporates restriction enzymes into chromatin immunoprecipitation fragments before amplification. The improved method allows the sample sizes to be several orders of magnitude less than that required for standard ChIP-Seq techniques. | 08-04-2011 |
20130217027 | AGENTS PROVIDING CONTROLS AND STANDARDS FOR IMMUNO-PRECIPITATION ASSAYS - Control agents for immuno-precipitation assays, methods of using the control agents and kits comprising the control agents are provided. | 08-22-2013 |
20150057163 | SYSTEMS AND METHODS FOR EPIGENETIC SEQUENCING - The present invention generally relates to microfluidics and/or epigenetic sequencing. In one set of embodiments, cells contained within a plurality of microfluidic droplets are lysed and the DNA (e.g., from nucleosomes) within the droplets are labeled, e.g., with adapters containing an identification sequence. The adapters may also contain other sequences, e.g., restriction sites, primer sites, etc., to assist with later analysis. After labeling with adapters, the DNA from the different cells may be combined and analyzed, e.g., to determine epigenetic information about the cells. For example, the DNA may be separated on the basis of certain modifications (e.g., methylation), and the DNA from the separated nucleosomes may be sequenced using techniques such as chromatin immunoprecipitation (“ChIP”). In some cases, the DNA sequences may also be aligned with genomes, e.g., to determine which portions of the genome were epigenetically modified, e.g., via methylation. | 02-26-2015 |
20150174138 | DIAGNOSTIC AND TREATMENT METHODS IN SUBJECTS HAVING OR AT RISK OF DEVELOPING RESISTANCE TO CANCER THERAPY - The invention relates to methods of treatment and diagnosis of subjects with cancer. In some aspects, the invention relates to methods of treatment and diagnosis of subjects with cancer, wherein the cancer is characterized by a Notch pathway activation mutation or by resistance to a Notch pathway inhibitor. | 06-25-2015 |
20150267176 | TRANSCRIPTION ACTIVATOR-LIKE EFFECTOR (TALE) - LYSINE-SPECIFIC DEMETHYLASE 1 (LSD1) FUSION PROTEINS - Fusion proteins comprising a DNA binding domain, e.g., a TAL effector repeat array (TALE) or zinc finger array, and a catalytic domain comprising a sequence that catalyzes histone demethylation, and methods of use thereof. | 09-24-2015 |
20160068885 | AGENTS PROVIDING CONTROLS AND STANDARDS FOR IMMUNOPRECIPITATION ASSAYS - Control agents for immunoprecipitation assays, methods of using the control agents and kits comprising the control agents are provided. | 03-10-2016 |
David Bernstein, Newton, MA US
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20150026715 | In-stream video advertising using a user-choice-based ad unit - A choice-based ad unit format wherein a user chooses his or her pre-roll ad or can choose to wait for the main content to load. Once the video advertisement selected loads, the user can then choose to skip the ad or view the entire ad experience. Preferably, the ad viewing experience is integrated with a site to enable the ad unit to have unlimited access to in-stream inventory that is otherwise available from the site. | 01-22-2015 |
Debra Bernstein, Sudbury, MA US
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20090119671 | REGISTERS FOR DATA TRANSFERS - A system and method for employing registers for data transfer in multiple hardware contexts and programming engines to facilitate high performance data processing. The system and method includes a processor that includes programming engines with registers for transferring data from one of the registers residing in an executing programming engine to a subsequent one of the registers residing in an adjacent programming engine. | 05-07-2009 |
20090182989 | MULTITHREADED MICROPROCESSOR WITH REGISTER ALLOCATION BASED ON NUMBER OF ACTIVE THREADS - A mechanism in a multithreaded processor to allocate resources based on configuration information indicating how many threads are in use. | 07-16-2009 |
20090307469 | REGISTER SET USED IN MULTITHREADED PARALLEL PROCESSOR ARCHITECTURE - A parallel hardware-based multithreaded processor is described. The processor includes a general purpose processor that coordinates system functions and a plurality of microengines that support multiple hardware threads or contexts. The processor maintains execution threads. The execution threads access a register set organized into a plurality of relatively addressable windows of registers that are relatively addressable per thread. | 12-10-2009 |
20140201471 | Arbitrating Memory Accesses Via A Shared Memory Fabric - In an embodiment, a shared memory fabric is configured to receive memory requests from multiple agents, where at least some of the requests have an associated deadline value to indicate a maximum latency prior to completion of the memory request. Responsive to the requests, the fabric is to arbitrate between the requests based at least in part on the deadline values. Other embodiments are described and claimed. | 07-17-2014 |
20150081999 | MEMORY MAPPING IN A PROCESSOR HAVING MULTIPLE PROGRAMMABLE UNITS - The disclosure includes, in general, among other aspects, an apparatus having multiple programmable units integrated within a processor. The apparatus has circuitry to map addresses in a single address space to resources within the multiple programmable units where the single address space includes addresses for different ones of the resources in different ones of the multiple programmable units and where there is a one-to-one correspondence between respective addresses in the single address space and resources within the multiple programmable units. | 03-19-2015 |
20160034420 | MEMORY MAPPING IN A PROCESSOR HAVING MULTIPLE PROGRAMMABLE UNITS - The disclosure includes, in general, among other aspects, an apparatus having multiple programmable units integrated within a processor. The apparatus has circuitry to map addresses in a single address space to resources within the multiple programmable units where the single address space includes addresses for different ones of the resources in different ones of the multiple programmable units and where there is a one-to-one correspondence between respective addresses in the single address space and resources within the multiple programmable units. | 02-04-2016 |
20160070664 | MEMORY MAPPING IN A PROCESSOR HAVING MULTIPLE PROGRAMMABLE UNITS - The disclosure includes, in general, among other aspects, an apparatus having multiple programmable units integrated within a processor. The apparatus has circuitry to map addresses in a single address space to resources within the multiple programmable units where the single address space includes addresses for different ones of the resources in different ones of the multiple programmable units and where there is a one-to-one correspondence between respective addresses in the single address space and resources within the multiple programmable units. | 03-10-2016 |
20160071558 | MEMORY MAPPING IN A PROCESSOR HAVING MULTIPLE PROGRAMMABLE UNITS - The disclosure includes, in general, among other aspects, an apparatus having multiple programmable units integrated within a processor. The apparatus has circuitry to map addresses in a single address space to resources within the multiple programmable units where the single address space includes addresses for different ones of the resources in different ones of the multiple programmable units and where there is a one-to-one correspondence between respective addresses in the single address space and resources within the multiple programmable units. | 03-10-2016 |
Debra Bernstein, Sunbury, MA US
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20110113197 | QUEUE ARRAYS IN NETWORK DEVICES - A queue descriptor including a head pointer pointing to the first element in a queue and a tail pointer pointing to the last element in the queue is stored in memory. In response to a command to perform an enqueue or dequeue operation with respect to the queue, fetching from the memory to a cache only one of either the head pointer or tail pointer and returning to the memory from the cache portions of the queue descriptor modified by the operation. | 05-12-2011 |
Douglas A. Bernstein, Somerville, MA US
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20090203754 | ANTI-BACTERIAL DRUG TARGETING OF GENOME MAINTENANCE INTERFACES - Methods for the design and identification of novel antimicrobial compounds are provided, as well as antimicrobial compounds identified using these methods. Pharmaceutical compositions that include these antimicrobial compounds are provided as well. The antimicrobial compounds inhibit the binding of a prokaryotic single-stranded DNA binding protein to a polypeptide. In some examples, the prokaryotic single-stranded DNA binding protein is prokaryotic exonuclease I. | 08-13-2009 |
Howard Bernstein, Cambridge, MA US
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20100062066 | Formulations of Tetrahydropyridine Antiplatelet Agents for Parenteral or Oral Administration - A pharmaceutical composition for the oral or parenteral administration of a compound of Formula (I) comprising an oil in water emulsion, wherein the oil phase comprises the free base of or a pharmaceutically acceptable salt thereof of a compound of Formula (I), and one or more surfactants which are soluble in the oil phase and/or the aqueous phase. The emulsion optionally contains one or more excipients that are soluble in the oil phase and/or the aqueous phase, such as pH modifying agents such as buffers, osmolality/tonicity modifying agents, emulsifying agents, water-soluble polymers, and preservatives. The compound of Formula (I) can be formulated as a solid material and stored until needed. Kits for forming the emulsion are provided. Prior to administration, the solid material can be reconstituted in an aqueous medium to form the emulsion. | 03-11-2010 |
20100249560 | OXYGEN SENSOR - The present invention generally relates to systems and methods for determining oxygen in a sample, or in a subject. In one aspect, the present invention is generally directed to an article exhibiting a determinable feature responsive to oxygen, such as oxygen-sensitive particles. The particles may exhibit a determinable change with a change in oxygen concentration, and such particles can accordingly be used to determine oxygen. For example, in one set of embodiments, the particles may be at least partially coated with a protein, such as hemoglobin, that is able to interact with oxygen. In some cases, the protein may aggregate under certain conditions (e.g., under relatively low oxygen concentrations), and such protein aggregation may be used, for example, to cause the particles to become aggregated, which can be determined in some way. In some cases, such aggregation may be irreversible; i.e., the degree of aggregation corresponds to the most extreme oxygen concentrations that the proteins were exposed to. Such articles may be used, for example, to determine oxygen within a sample, or within a subject, such as a human subject. For instance, the article may be formed as a skin patch, or administered to the skin of a subject, e.g., on the surface of the skin, within the dermis or epidermis, etc., to determine oxygen within the subject. | 09-30-2010 |
20100330703 | ASSAYS INVOLVING COLORIMETRIC AND OTHER SIGNALING - The present invention generally relates to particles and, in particular, to methods of determining binding involving particles, e.g., using colorimetric and other signaling techniques. In one aspect, a mixture of particles of different colors (e.g., at least a first color and a second color) is provided that exhibits a first collective color, e.g., due to the presence of the different colors of particles within the mixture. The mixture can then be exposed to a medium containing a binding partner able to preferentially bind to some of the particles, e.g., particles of a first color relative to particles of a second color. The bound particles can be separated in some fashion (e.g., filtration, gravity, magnetism, centrifugal separation, etc.), such that the mixture exhibits a second collective color, e.g., due to the presence of a greater number of particles of the second color relative to the number of particles of the first color. Accordingly, by visualizing or otherwise determining a color change, a binding event may be determined. Other aspects of the invention relate to kits involving such particles, methods of promoting the making or use of such particles, or the like. | 12-30-2010 |
20110009847 | SYSTEMS AND METHODS FOR CREATING AND USING SUCTION BLISTERS OR OTHER POOLED REGIONS OF FLUID WITHIN THE SKIN - The present invention generally relates to devices and techniques associated with diagnostics, therapies, and other applications, including skin-associated applications, for example, devices for delivering and/or withdrawing fluid from subjects, e.g., through the skin. In some embodiments, the device includes a system for accessing an extractable medium from and/or through the skin of the subject at an access site, and a pressure regulator supported by a support structure, able to create a pressure differential across the skin at least a portion of the access site. The device may also include, in some cases, a sensor supported by the support structure for determining at least one condition of the extractable medium from the subject, and optionally a signal generator supported by the support structure for generating a signal relating to the condition of the medium determined by the sensor. | 01-13-2011 |
20110105872 | SYSTEMS AND METHODS FOR APPLICATION TO SKIN AND CONTROL OF ACTUATION, DELIVERY, AND/OR PERCEPTION THEREOF - The present invention generally relates, in certain aspects, to systems and methods for application to the skin, and control of actuation, delivery, and/or perception thereof. For example, certain aspects of the invention are generally directed to devices for delivering to and/or withdrawing fluid or from subjects, e.g., to or from the skin and/or beneath the skin. In one aspect, the delivery and/or withdrawal of fluid is at least partially obscured. For example, the obscuration may be by time, and/or by sensory obscuration (e.g., by providing tactile, olfactory, auditory, and/or visual sensations). Certain aspects of the invention are generally directed to devices able to automatically deliver to and/or withdraw fluid from the skin and/or beneath the skin after activation, e.g., where the fluid is delivered and/or withdrawn without the need for any additional intervention. The devices may be activated by any suitable technique. In other aspects, a device may be contained in a package, and when removed from the package, the device may be constructed and arranged to be able to deliver and/or withdraw fluid when the device is applied to the skin, and in some cases, automatically and/or without any further intervention by the subject or another person. | 05-05-2011 |
20110105951 | SYSTEMS AND METHODS FOR TREATING, SANITIZING, AND/OR SHIELDING THE SKIN OR DEVICES APPLIED TO THE SKIN - The present invention generally relates, in certain aspects, to systems and methods for treating, sanitizing, and/or shielding blood on the surface of the skin or devices applied to the skin. In one set of embodiments, while blood is withdrawn from the skin of the subject, the blood is covered and/or shielded such that the blood is not seen by the subject. In another set of embodiments, any blood present on the skin may be altered or treated such that it no longer appears as blood, e.g., by exposing the blood to a chemical such as a peroxide that alters the color of the blood. In yet another set of embodiments, blood present on the skin is withdrawn or taken up by the device such that visible residual blood is not present in an amount visible to the unaided eye once the device is removed. In some cases, the same device may be used to sanitize the skin and deliver to and/or withdraw fluid from the skin and/or beneath the skin. The sanitization may be performed before, during, or after delivering to and/or withdrawing fluid from the skin and/or beneath the skin. Sanitization may be performed, for example, using a sanitizer such as hydrogen peroxide, ethyl alcohol, isopropyl alcohol, or the like. | 05-05-2011 |
20110105952 | RELATIVELY SMALL DEVICES APPLIED TO THE SKIN, MODULAR SYSTEMS, AND METHODS OF USE THEREOF - The present invention generally relates, in certain aspects, to relatively small devices applied to the skin, modular systems, and methods of use thereof. In some aspects, the device is constructed and arranged to have more than one module. For instance, the device may have a module for delivering to and/or withdrawing fluid from the skin and/or beneath the skin of a subject and a module for transmitting a signal indicative of the fluid delivered to and/or withdrawn from the skin and/or beneath the skin of the subject, a module for analyzing a fluid withdrawn from the skin and/or beneath the skin of the subject, or the like. In some embodiments, the modules are connectable and/or detachable from each other, and in some cases, the connections and/or detachments may be performed while the device is in contact with the subject, e.g., while affixed to the subject. In some embodiments, the device may be repeatedly applicable to the skin of the subject to deliver to and/or withdraw fluid from the skin and/or beneath the skin of a subject, e.g., at the same location, or at different locations on the skin of the subject. In some aspects, the devices may be self-contained and/or have a relatively small size, and in some cases, the device may be sized such that it is wearable and/or able to be carried by a subject. For example, the device may have a mass and/or dimensions that allow the device to be carried or worn by a subject for various periods of time, e.g., at least about an hour, at least about a day, at least about a week, etc., or no more than about an hour, no more than about 10 min, etc. | 05-05-2011 |
20110125058 | PATIENT-ENACTED SAMPLING TECHNIQUE - The present invention is generally directed to systems and methods for sampling fluids from subjects. The fluid may be any suitable bodily fluid, e.g., blood or interstitial fluid. In some cases, the subject is a patient. The subject may have a device that can be applied to the skin of the subject (e.g., by the subject, or another person), and the device is able to obtain a sample of fluid. The fluid may be stored within a reservoir in the device, and the fluid may be obtained from the subject at any convenient time, e.g., at home, away from a healthcare setting, etc. In some embodiments, the device, or a portion thereof, may be returned to a clinical and/or laboratory setting to analyze the fluid stored within the device. | 05-26-2011 |
20110129533 | POROUS DRUG MATRICES AND METHODS OF MANUFACTURE THEREOF - Drugs, especially low aqueous solubility drugs, are provided in a porous matrix form, preferably microparticles, which enhances dissolution of the drug in aqueous media. The drug matrices preferably are made using a process that includes (i) dissolving a drug, preferably a drug having low aqueous solubility, in a volatile solvent to form a drug solution, (ii) combining at least one pore forming agent with the drug solution to form an emulsion, suspension, or second solution and hydrophilic or hydrophobic excipients that stabilize the drug and inhibit crystallization, and (iii) removing the volatile solvent and pore forming agent from the emulsion, suspension, or second solution to yield the porous matrix of drug. Hydrophobic or hydrophilic excipients may be selected to stabilize the drug in crystalline form by inhibiting crystal growth or to stabilize the drug in amorphous form by preventing crystallization. The pore forming agent can be either a volatile liquid that is immiscible with the drug solvent or a volatile solid compound, preferably a volatile salt. In a preferred embodiment, spray drying is used to remove the solvents and the pore forming agent. The resulting porous matrix has a faster rate of dissolution following administration to a patient, as compared to non-porous matrix forms of the drug. In a preferred embodiment, microparticles of the porous drug matrix are reconstituted with an aqueous medium and administered parenterally, or processed using standard techniques into tablets or capsules for oral administration. | 06-02-2011 |
20110172508 | SAMPLING DEVICE INTERFACES - The present invention generally relates to systems and methods for delivering and/or withdrawing a substance or substances such as blood or interstitial fluid, from subjects, e.g., from the skin and/or from beneath the skin. In one aspect, the present invention is generally directed to devices and methods for withdrawing or extracting blood from a subject, e.g., from the skin and/or from beneath the skin, using devices containing a fluid transporter (for example, one or more microneedles), and a storage chamber having an internal pressure less than atmospheric pressure prior to receiving blood. In some cases, the device may be self-contained, and in certain instances, the device can be applied to the skin, and activated to withdraw blood from the subject. The device, in some cases, may be interfaced with external equipment to determine an analyte contained within a fluid contained within or collected by the device. For example, the device may be mounted or engaged on an external holder, the device may include a port for transporting fluid out of the device, the device may include a window for interrogating a fluid contained within the device, or the like. The device, or a portion thereof, may then be processed to determine the blood and/or an analyte within the blood, alone or with an external apparatus. For example, blood may be withdrawn from the device, and/or the device may contain sensors or agents able to determine the blood and/or an analyte suspected of being contained in the blood. Other aspects of the present invention are directed at other devices for withdrawing blood (or other bodily fluids, e.g., interstitial fluid), kits involving such devices, methods of making such devices, methods of using such devices, and the like. | 07-14-2011 |
20110172510 | RAPID DELIVERY AND/OR WITHDRAWAL OF FLUIDS - The present invention generally relates to systems and methods for delivering and/or withdrawing a substance or substances such as blood or interstitial fluid, from subjects, e.g., from the skin and/or from beneath the skin. In one aspect, the present invention is generally directed to devices and methods for withdrawing or extracting blood from a subject, e.g., from the skin and/or from beneath the skin, using devices containing a fluid transporter (for example, one or more microneedles), and a storage chamber having an internal pressure less than atmospheric pressure prior to receiving blood. In some cases, the device may be self-contained, and in certain instances, the device can be applied to the skin, and activated to withdraw blood from the subject. The device, or a portion thereof, may then be processed to determine the blood and/or an analyte within the blood, alone or with an external apparatus. For example, blood may be withdrawn from the device, and/or the device may contain sensors or agents able to determine the blood and/or an analyte suspected of being contained in the blood. Other aspects of the present invention are directed at other devices for withdrawing blood (or other bodily fluids, e.g., interstitial fluid), kits involving such devices, methods of making such devices, methods of using such devices, and the like. | 07-14-2011 |
20110181410 | MONITORING OR FEEDBACK SYSTEMS AND METHODS - The present invention generally relates to systems and methods for monitoring and/or providing feedback for drugs or other pharmaceuticals taken by a subject. In one aspect, the present invention is directed to devices and methods for determining a species within the skin of a subject; and producing feedback to a subject based on the determination of the species. The feedback may be, for example, visual, audible, tactile, a change in temperature, etc. In some cases, information regarding the determination of the species may be transmitted to another entity, e.g., a health care provider, a computer, a relative, etc., which may then provide feedback to the subject in some fashion. In some cases, the feedback may be directly indicative of the species, e.g., whether the species is present, the concentration of the species, whether a by-product of a reaction involving the species is present, whether a compound affected by the species is present, etc. However, the feedback may also be indirect in some embodiments. For example, the subject may be presented with an external reward, e.g., based on the determination of the species within the skin. For instance, a reward such as cash, coupons, songs, discounts, personal items, etc., may be offered based on the level of compliance of the subject. Still other aspects of the invention are generally directed to kits involving such devices (with or without the drug to be monitored), methods of promoting such systems, or the like. | 07-28-2011 |
20110251562 | RAPID DELIVERY AND/OR WITHDRAWAL OF FLUIDS - The present invention generally relates to systems and methods for delivering and/or withdrawing a substance or substances such as blood or interstitial fluid, from subjects, e.g., from the skin and/or from beneath the skin. In one aspect, the present invention is generally directed to devices and methods for withdrawing or extracting blood from a subject, e.g., from the skin and/or from beneath the skin, using devices containing a fluid transporter (for example, one or more microneedles), and a storage chamber having an internal pressure less than atmospheric pressure prior to receiving blood. In some cases, the device may be self-contained, and in certain instances, the device can be applied to the skin, and activated to withdraw blood from the subject. The device, or a portion thereof, may then be processed to determine the blood and/or an analyte within the blood, alone or with an external apparatus. For example, blood may be withdrawn from the device, and/or the device may contain sensors or agents able to determine the blood and/or an analyte suspected of being contained in the blood. Other aspects of the present invention are directed at other devices for withdrawing blood (or other bodily fluids, e.g., interstitial fluid), kits involving such devices, methods of making such devices, methods of using such devices, and the like. | 10-13-2011 |
20110288389 | OXYGEN SENSOR - The present invention generally relates to systems and methods for determining oxygen in a sample, or in a subject. In one aspect, the present invention is generally directed to an article exhibiting a determinable feature responsive to oxygen, such as oxygen-sensitive particles. The particles may exhibit a determinable change with a change in oxygen concentration, and such particles can accordingly be used to determine oxygen. For example, in one set of embodiments, the particles may be at least partially coated with a protein, such as hemoglobin, that is able to interact with oxygen. In some cases, the protein may aggregate under certain conditions (e.g., under relatively low oxygen concentrations), and such protein aggregation may be used, for example, to cause the particles to become aggregated, which can be determined in some way. In some cases, such aggregation may be irreversible; i.e., the degree of aggregation corresponds to the most extreme oxygen concentrations that the proteins were exposed to. Such articles may be used, for example, to determine oxygen within a sample, or within a subject, such as a human subject. For instance, the article may be formed as a skin patch, or administered to the skin of a subject, e.g., on the surface of the skin, within the dermis or epidermis, etc., to determine oxygen within the subject. | 11-24-2011 |
20120010529 | SAMPLING DEVICES AND METHODS INVOLVING RELATIVELY LITTLE PAIN - The present invention generally relates to systems and methods for delivering and/or receiving a substance or substances such as blood, from subjects, e.g., to the skin and/or from the skin. In one aspect, the present invention is generally directed to devices and methods for receiving blood from a subject, e.g., from the skin, using devices including a substance transfer component (which may contain, for example, one or more microneedles), and a storage chamber having an internal pressure less than atmospheric pressure prior to receiving blood. In certain embodiments, substances may be received from and/or delivered to the subject with relatively little pain. The pain may be assessed, to for example, using pain scales such as the Wong-Baker FACES Pain Scale. In some cases, the device may be self-contained, and in certain instances, the device can be applied to the skin, and activated to receive blood from the subject. The device, or a portion thereof, may then be processed to determine the blood and/or an analyte within the blood, alone or with an external apparatus. For example, blood may be received from the device, and/or the device may contain sensors or agents able to determine the blood and/or an analyte suspected of being contained in the blood. Other aspects of the present invention are directed at other devices for receiving blood (or other bodily fluids, e.g., interstitial fluid), kits involving such devices, methods of making such devices, methods of using such devices, and the like. | 01-12-2012 |
20120039809 | SYSTEMS AND TECHNIQUES FOR MONITORING SUBJECTS - The present invention generally relates to systems and methods for monitoring and/or providing feedback for drugs or other pharmaceuticals taken by a subject. In one aspect, the present invention is directed to devices and methods for determining a species within the skin of a subject; and producing feedback to a subject based on the determination of the species. The feedback may be, for example, visual, audible, tactile, a change in temperature, etc. In some cases, information regarding the determination of the species may be transmitted to another entity, e.g., a health care provider, a computer, a relative, etc., which may then provide feedback to the subject in some fashion. In some cases, the feedback may be directly indicative of the species, e.g., whether the species is present, the concentration of the species, whether a by-product of a reaction involving the species is present, whether a compound affected by the species is present, etc. However, the feedback may also be indirect in some embodiments. For example, the subject may be presented with an external reward, e.g., based on the determination of the species within the skin. For instance, a reward such as cash, coupons, songs, discounts, personal items, etc., may be offered based on the level of compliance of the subject. Still other aspects of the invention are generally directed to kits involving such devices (with or without the drug to be monitored), methods of promoting such systems, or the like. | 02-16-2012 |
20120041338 | CLINICAL AND/OR CONSUMER TECHNIQUES AND DEVICES - The present invention generally relates to systems and methods for delivering and/or receiving a substance or substances such as blood, from subjects, e.g., from the skin and/or from other tissues of the body. In some cases, the device may contain a substance transfer component such as needles or microneedles, which can be inserted into the skin or another organ to deliver and/or receiving fluid or other substances from the subject. In some embodiments, the device may include an activator constructed and arranged to insert one or more substance transfer components into the skin or other organ. In certain cases, the device may also include a storage chamber for receiving a fluid received from the subject. | 02-16-2012 |
20120271125 | DEVICES AND METHODS FOR DELIVERY AND/OR WITHDRAWAL OF FLUIDS AND PRESERVATION OF WITHDRAWN FLUIDS - The present invention generally relates to systems and methods for delivering and/or withdrawing a substance or substances such as blood or interstitial fluid, from subjects, e.g., from the skin and/or from beneath the skin. In one aspect, the present invention is generally directed to devices and methods for withdrawing or extracting blood from a subject, e.g., from the skin and/or from beneath the skin, using devices containing a fluid transporter (for example, one or more microneedles), and a storage chamber having an internal pressure less than atmospheric pressure prior to receiving blood. In some cases, the device may be self-contained, and in certain instances, the device can be applied to the skin, and activated to withdraw blood from the subject. The device, or a portion thereof, may then be processed to determine the blood and/or an analyte within the blood, alone or with an external apparatus. | 10-25-2012 |
20120275955 | PLASMA OR SERUM PRODUCTION AND REMOVAL OF FLUIDS UNDER REDUCED PRESSURE - In some embodiments, the present invention generally relates to the separation of blood within a device to form plasma or serum. In some embodiments, the present invention generally relates to the removal of fluids, such as blood, contained within a device. For example, a device may be applied to the skin of a subject to receive blood from the subject and pass the blood through a separation membrane, which separates the blood into plasma and a portion concentrated in blood cells. As another example, blood or plasma may be allowed to clot within the device and serum (the unclotted portion of the blood) may be withdrawn from the device. The device may contain, in some cases, a vacuum source such as a pre-packaged vacuum to facilitate receiving of blood and/or passage of the blood through the separation membrane to produce plasma or serum. | 11-01-2012 |
20120277629 | SYSTEMS AND METHODS FOR COLLECTION AND/OR MANIPULATION OF BLOOD SPOTS OR OTHER BODILY FLUIDS - The present invention generally relates to systems and methods for receiving blood (or other bodily fluids) from a subject, e.g., from or beneath the skin of a subject. In some cases, the blood (or other bodily fluids) may be deposited on a membrane or other substrate. For example, blood may be absorbed in a substrate, and dried in some cases to produce a dried blood spot. In one aspect, the present invention is generally directed to devices and methods for receiving blood from a subject, e.g., from the skin, using devices including a substance transfer component (which may contain, for example, one or more microneedles), and directing the blood on a substrate, e.g., for absorbing blood. The substrate, in some embodiments, may comprise filter paper or cotton-based paper. After absorption of some blood onto the substrate, the substrate may be removed from the device and shipped or analyzed. | 11-01-2012 |
20130079666 | DELIVERING AND/OR RECEIVING FLUIDS - The present invention generally relates to receiving bodily fluid through a device opening. In one aspect, the device includes a flow activator arranged to cause fluid to be released from a subject. A deployment actuator may actuate the flow activator in a deployment direction, which may in turn cause fluid release from a subject. The flow activator may also be moved in a retraction direction by a retraction actuator. In one aspect, the device may include a vacuum source that may help facilitate fluid flow into the opening of the device and/or may help facilitate fluid flow from the opening to a storage chamber. In one aspect, a device actuator may enable fluid communication between the opening and the vacuum source and the flow activator may be actuated after the enablement of fluid communication. | 03-28-2013 |
20130158468 | DELIVERING AND/OR RECEIVING MATERIAL WITH RESPECT TO A SUBJECT SURFACE - The present invention generally relates to receiving bodily fluid through a device opening. In one aspect, the device includes a flow activator arranged to cause fluid to be released from a subject. The flow activator may be actuated in a deployment direction by a deployment actuator, which may in turn cause fluid release from a subject. The flow activator may also be moved in a retraction direction by a retraction actuator. In one aspect, the device may include a vacuum source that may help facilitate fluid flow into the opening of the device and/or may help facilitate fluid flow from the opening to a storage chamber. In one aspect, an effector may enable fluid communication between the opening and the vacuum source and may do so in response to actuation of the flow activator. | 06-20-2013 |
20150038876 | DELIVERING AND/OR RECEIVING FLUIDS - The present invention generally relates to receiving bodily fluid through a device opening. In one aspect, the device includes a flow activator arranged to cause fluid to be released from a subject. A deployment actuator may actuate the flow activator in a deployment direction, which may in turn cause fluid release from a subject. The flow activator may also be moved in a retraction direction by a retraction actuator. In one aspect, the device may include a vacuum source that may help facilitate fluid flow into the opening of the device and/or may help facilitate fluid flow from the opening to a storage chamber. In one aspect, a device actuator may enable fluid communication between the opening and the vacuum source and the flow activator may be actuated after the enablement of fluid communication. | 02-05-2015 |
20150057510 | PATIENT-ENACTED SAMPLING TECHNIQUE - The present invention is generally directed to systems and methods for sampling fluids from subjects. The fluid may be any suitable bodily fluid, e.g., blood or interstitial fluid. In some cases, the subject is a patient. The subject may have a device that can be applied to the skin of the subject (e.g., by the subject, or another person), and the device is able to obtain a sample of fluid. The fluid may be stored within a reservoir in the device, and the fluid may be obtained from the subject at any convenient time, e.g., at home, away from a healthcare setting, etc. In some embodiments, the device, or a portion thereof, may be returned to a clinical and/or laboratory setting to analyze the fluid stored within the device. | 02-26-2015 |
20150087944 | TECHNIQUES AND DEVICES ASSOCIATED WITH BLOOD SAMPLING - The present invention generally relates to devices and techniques associated with diagnostics, therapies, and other applications, including skin-associated applications, for example, devices for delivering and/or withdrawing fluid from subjects, e.g., through the skin. In some embodiments, the device includes a system for accessing an extractable medium from and/or through the skin of the subject at an access site, and a pressure regulator supported by a support structure, able to create a pressure differential across the skin at at least a portion of the access site. The device may also include, in some cases, a sensor supported by the support structure for determining at least one condition of the extractable medium from the subject, and optionally a signal generator supported by the support structure for generating a signal relating to the condition of the medium determined by the sensor. | 03-26-2015 |
20150278476 | MONITORING OR FEEDBACK SYSTEMS AND METHODS - The present invention generally relates to systems and methods for monitoring and/or providing feedback for drugs or other pharmaceuticals taken by a subject. In one aspect, the present invention is directed to devices and methods for determining a species within the skin of a subject; and producing feedback to a subject based on the determination of the species. The feedback may be, for example, visual, audible, tactile, a change in temperature, etc. In some cases, information regarding the determination of the species may be transmitted to another entity, e.g., a health care provider, a computer, a relative, etc., which may then provide feedback to the subject in some fashion. In some cases, the feedback may be directly indicative of the species, e.g., whether the species is present, the concentration of the species, whether a by-product of a reaction involving the species is present, whether a compound affected by the species is present, etc. However, the feedback may also be indirect in some embodiments. For example, the subject may be presented with an external reward, e.g., based on the determination of the species within the skin. For instance, a reward such as cash, coupons, songs, discounts, personal items, etc., may be offered based on the level of compliance of the subject. Still other aspects of the invention are generally directed to kits involving such devices (with or without the drug to be monitored), methods of promoting such systems, or the like. | 10-01-2015 |
20150313522 | DEVICES AND TECHNIQUES ASSOCIATED WITH DIAGNOSTICS, THERAPIES, AND OTHER APPLICATIONS, INCLUDING SKIN-ASSOCIATED APPLICATIONS - The present invention generally relates to devices and techniques associated with diagnostics, therapies, and other applications, including skin-associated applications, for example, devices for delivering and/or withdrawing fluid from subjects, e.g., through the skin. In some embodiments, the device includes a system for accessing an extractable medium from and/or through the skin of the subject at an access site, and a pressure regulator supported by a support structure, able to create a pressure differential across the skin at at least a portion of the access site. The device may also include, in some cases, a sensor supported by the support structure for determining at least one condition of the extractable medium from the subject, and optionally a signal generator supported by the support structure for generating a signal relating to the condition of the medium determined by the sensor. | 11-05-2015 |
20150320349 | PLASMA OR SERUM PRODUCTION AND REMOVAL OF FLUIDS UNDER REDUCED PRESSURE - In some embodiments, the present invention generally relates to the separation of blood within a device to form plasma or serum. In some embodiments, the present invention generally relates to the removal of fluids, such as blood, contained within a device. In one aspect, the present invention is generally directed to systems and methods for receiving blood from a subject and processing the blood to form plasma or serum. For example, a device may be applied to the skin of a subject to receive blood from the subject and pass the blood through a separation membrane, which separates the blood into plasma and a portion concentrated in blood cells. As another example, blood or plasma may be allowed to clot within the device and serum (the unclotted portion of the blood) may be withdrawn from the device. The device may contain, in some cases, a vacuum source such as a pre-packaged vacuum to facilitate receiving of blood and/or passage of the blood through the separation membrane to produce plasma or serum. In certain embodiments, plasma, serum, or other fluids may be removed from the device by inserting a needle into a portion of the device that has reduced pressure, expelling gas into the device through the needle, then receiving plasma, serum, or other fluids through the needle. | 11-12-2015 |
20160038068 | SAMPLING DEVICES AND METHODS INVOLVING RELATIVELY LITTLE PAIN - The present invention generally relates to systems and methods for delivering and/or receiving a substance or substances such as blood, from subjects, e.g., to the skin and/or from the skin. In one aspect, the present invention is generally directed to devices and methods for receiving blood from a subject, e.g., from the skin, using devices including a substance transfer component (which may contain, for example, one or more microneedles), and a storage chamber having an internal pressure less than atmospheric pressure prior to receiving blood. In certain embodiments, substances may be received from and/or delivered to the subject with relatively little pain. The pain may be assessed, for example, using pain scales such as the Wong-Baker FACES Pain Scale. In some cases, the device may be self-contained, and in certain instances, the device can be applied to the skin, and activated to receive blood from the subject. The device, or a portion thereof, may then be processed to determine the blood and/or an analyte within the blood, alone or with an external apparatus. For example, blood may be received from the device, and/or the device may contain sensors or agents able to determine the blood and/or an analyte suspected of being contained in the blood. Other aspects of the present invention are directed at other devices for receiving blood (or other bodily fluids, e.g., interstitial fluid), kits involving such devices, methods of making such devices, methods of using such devices, and the like. | 02-11-2016 |
Howard B. Bernstein, Lexington, MA US
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20090144665 | SYSTEMS, METHODS AND COMPUTER PROGRAM PRODUCTS FOR GRAPHICAL USER INTERFACE PRESENTATION TO IMPLEMENT FILTERING OF A LARGE UNBOUNDED HIERARCHY TO AVOID REPETITIVE NAVIGATION - Systems, methods, and computer program products for graphical user interface presentation to implement filtering of a large unbounded hierarchy. Exemplary embodiments include a system having a processor for retrieving the file hierarchy tree for presentation on a computer monitor, the file hierarchy tree representative of a plurality of nodes, navigating the file hierarchy tree to identify nodes for selection in a sub-group of nodes, presenting the selected node with a highlight on the computer monitor, displaying a menu on the computer monitor including an option to create a filter, displaying a popup dialog box on the computer monitor, the popup dialog box including an option to create a new filter and edit an existing filter, and displaying a filtered hierarchy tree on the computer monitor, the filtered hierarchy tree including the sub-group of nodes. | 06-04-2009 |
20110153557 | MIGRATION OF VERSIONED DATA BETWEEN CONFIGURATION MANAGEMENT SYSTEMS - Described is a method for migrating versioned data from a source configuration management system to a target configuration management system. The method includes determining, for at least one historical period having versioned data items to be migrated from the source to target systems, an earliest versioned data item based on a start time for the historical period. At least one subsequent versioned data item is determined based on a sampling interval and an end time for the historical period. The earliest versioned data item and subsequent versioned data items for each historical period are migrated from the source configuration management system to the target configuration management system. Advantageously, migration is performed faster than if all existing versions are migrated and storage requirements are reduced. In addition, differencing tools in the target system can compare different versions of the migrated data items. | 06-23-2011 |
20120158657 | ROLE-SPECIFIC ACCESS CONTROL TO SECTIONS OF ARTIFACT CONTENT WITHIN A CONFIGURATION MANAGEMENT (CM) SYSTEM - An artifact having at least one role-specific content section can be stored in a repository by a configuration management system. The role-specific content section can be associated with a specific role value. A request to access the stored artifact can be received. The request can include at least an identifier of a requestor, a role value of the requestor, and a version identifier of the artifact. A copy of the artifact specified in the received request can be created. The artifact copy can be modified to omit role-specific content sections inapplicable to the role value of the requestor. The modified artifact copy can be provided to the requestor. | 06-21-2012 |
20130174068 | PREFERENCE MANAGEMENT FOR APPLICATION CONTROLS - A preference management system, including: a graphical user interface (GUI) displayed on a display device; a GUI control corresponding to an application within the GUI, wherein the GUI control includes a preference that defines an aspect of the application; and a graphical affordance for the preference, wherein the graphical affordance is configured to execute an operation to set a default value of the corresponding preference to a current value of the preference in response to a user input, wherein the graphical affordance is configured to set the default value for the corresponding preference independently from other preferences in the GUI control, wherein the default value is stored in a memory device. | 07-04-2013 |
20150220331 | RESOLVING MERGE CONFLICTS THAT PREVENT BLOCKS OF PROGRAM CODE FROM PROPERLY BEING MERGED - This disclosure relates to resolving merge conflicts that prevent blocks of program code from properly being merged. A merge conflict that prevents blocks of program code from properly being merged can be identified. Responsive to identifying the merge conflict, a pattern of a respective portion of at least one of the blocks of program code can be identified, and a determination can be made as to whether the pattern matches an existing merge rule. Responsive to determining that the pattern matches the existing merge rule, the existing merge rule can be validated against a syntax of the portion of at least one of the blocks of program code. Responsive to the existing merge rule successfully validating against the syntax of the portion of at least one of the blocks of program code, the existing merge rule can be applied to resolve the merge conflict. | 08-06-2015 |
20150220332 | RESOLVING MERGE CONFLICTS THAT PREVENT BLOCKS OF PROGRAM CODE FROM PROPERLY BEING MERGED - This disclosure relates to resolving merge conflicts that prevent blocks of program code from properly being merged. A merge conflict that prevents blocks of program code from properly being merged can be identified. Responsive to identifying the merge conflict, a pattern of a respective portion of at least one of the blocks of program code can be identified, and a determination can be made as to whether the pattern matches an existing merge rule. Responsive to determining that the pattern matches the existing merge rule, the existing merge rule can be validated against a syntax of the portion of at least one of the blocks of program code. Responsive to the existing merge rule successfully validating against the syntax of the portion of at least one of the blocks of program code, the existing merge rule can be applied to resolve the merge conflict. | 08-06-2015 |
Jacob Bernstein, Cambridge, MA US
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20110087311 | Methods and Apparatus for Microstructure Lightguides - This invention may be implemented as a microstructure probe for delivering light of variable color and/or power, via a set of integrated lightguides, from an optical source (or set of sources) to regions spatially arranged 3-dimensionally, with a length scale of microns to millimeters. In exemplary embodiments of this invention, a microstructure probe comprises many lightguides and is adapted to be inserted into neural or other tissue. The lightguides run in parallel along at least a portion of the axis of the probe. The probe may deliver light to many points along the axis of insertion of the probe. | 04-14-2011 |
20120089205 | Methods and Apparatus for High-Throughput Neural Screening - In exemplary implementations of this invention, high-throughput screening of a mammalian brain is performed to locate neural circuit targets of interest. A variety of search patterns may be used for this neural screening, including (a) iterative subdivision, (b) serial search, and (c) combinatorial. To perform this neural screening, an array of optical fibers (or an array of waveguides) is inserted into the brain. Alternately, the array is positioned adjacent to the brain. Each fiber or waveguide in the array is coupled to a light source (LED or laser). The brain has been previously sensitized to light, using genetically encoded optical neural control reagents, which are delivered either using viruses or via transgenic means. In the screening, the array is used to optically perturb the brain. For example, the neurons of the brain may be activated by one color of light, and/or silenced by another color of light. | 04-12-2012 |
20140324138 | Wirelessly-powered illumination of biological tissue - In exemplary implementations of this invention, an implant device is wholly or partially implanted in a mammal. The implant device includes an antenna, circuitry, a supercapacitor, one or more light sources, and an array of optical fibers or light guides. The antenna and circuitry receive energy by wireless transmission from an external transmit coil. The supercapacitor stores at least a portion of the energy and provides power to one or more light sources. The array of optical fibers or light guides deliver light from the light sources to living tissue of a mammal. The tissue includes light-sensitive, heterologously expressed proteins. The light affects the light-sensitive proteins, triggering a change in all or part of the tissue, such as a change in voltage, pH or a change in function. | 10-30-2014 |
Jacob G. Bernstein, Cambridge, MA US
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20080306576 | Optical Cell Control Prosthetics - A prosthetic device for optical control of target cells comprises a set of light sources, hardware for guiding light to the target cells, supporting hardware that holds members of the set of light sources with respect to each other and the target cells, control circuitry for controlling the set of light sources, and power circuitry that provides power to the set of light sources and the control circuitry. The device may be wearable or implantable, and may be remotely powered or employ wireless communication. The supporting hardware may comprise implantable hypodermics or cannulas, or a plate or scaffold. The set of light sources may be assembled into an array. | 12-11-2008 |
20090210039 | Prosthetic system for therapeutic optical activation and silencing of genetically-targeted neurons - An optical prosthesis that permits control of neural circuits comprises a probe having a set of light sources, drive circuit connections connected to each light source, a housing surrounding the light sources and drive circuit connections, and drive circuitry for driving and controlling the probe. The drive circuit connections and drive circuitry may optionally provide for wireless communication. The light sources may be light-emitting diodes, lasers, or other suitable sources. The device may optionally include sensors for monitoring the target cells. The present invention is also a multi-dimensional array of probes, each probe having a set of light sources, drive circuit connections connected to each light source, a housing surrounding the light sources and the drive circuit connections, drive circuitry for driving and controlling the probes, and supporting hardware that holds the probes in position with respect to each other and the target cells. | 08-20-2009 |
Jeffrey Bernstein, Middleton, MA US
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20100220514 | STORAGE DEVICES WITH SOFT PROCESSING - A storage device includes a storage array having a group of storage elements. Each storage element can written to a discrete set of physical states. A read circuit selects one or more storage elements and generates, for each selected storage element, an analog signal representative of the physical state of the selected storage element. A signal processing circuit processes the analog signal to generate a plurality of outputs, with each output representing a degree of an association of the selected storage element with a different subset of one or more of the discrete set of physical states. | 09-02-2010 |
20100223225 | Analog computation using numerical representations with uncertainty - Some general aspects relate to systems and methods of analog computation using numerical representation with uncertainty. For example, a specification of a group of variables is accepted, with each variable having a set of at least N possible values. The group of variables satisfies a set of one or more constraints, and each variable is specified as a decomposition into a group of constituents, with each constituent having a set of M (e.g., M09-02-2010 | |
20100246287 | STORAGE DEVICES WITH SOFT PROCESSING - A storage device includes a storage array having a group of storage elements. Each storage element can written to a discrete set of physical states. A read circuit selects one or more storage elements and generates, for each selected storage element, an analog signal representative of the physical state of the selected storage element. A signal processing circuit processes the analog signal to generate a plurality of outputs, with each output representing a degree of an association of the selected storage element with a different subset of one or more of the discrete set of physical states. | 09-30-2010 |
20100246289 | STORAGE DEVICES WITH SOFT PROCESSING - A storage device includes a storage array having a group of storage elements. Each storage element can written to a discrete set of physical states. A read circuit selects one or more storage elements and generates, for each selected storage element, an analog signal representative of the physical state of the selected storage element. A signal processing circuit processes the analog signal to generate a plurality of outputs, with each output representing a degree of an association of the selected storage element with a different subset of one or more of the discrete set of physical states. | 09-30-2010 |
20100281089 | SIGNAL MAPPING - A circuit includes a signal processing circuit for accepting an input and for generating a set of outputs. The input is provided in an input range that has a set of representative values, and each output represents a measure of an association of the input with one or more of the representative values. The signal processing circuit includes a group of output sections, each output section being responsive to the input of the signal processing circuit. Each output section includes one or more sigmoid generators. Each sigmoid generator is responsive to an input of the output section to generate an output that represents a sigmoid function of the input of the output section. Each output section also includes a circuitry for combining the outputs of the one or more sigmoid generators to form one of the set of outputs of the signal processing circuit. An input transformation circuit is coupled to the plurality of output sections. The input transformation circuit is configurable to transform the input of the signal processing circuit for controlling a mapping characteristic from the input to the set of outputs. | 11-04-2010 |
20110255612 | MIXED SIGNAL STOCHASTIC BELIEF PROPAGATION - A processor implements a network of functional nodes and communication paths between the nodes. The processor includes a plurality of circuit implementations of the functional nodes of the processor; and a plurality of signal paths implementing the communication paths linking the circuit implementations of the nodes. At least some of the signal paths are configured to pass signal values represented according to temporal patterns of signal levels on the signal paths. The processor also includes a plurality of circuit components for conversion between a signal value represented as a signal level (e.g., voltage or current level) and a signal value represented as a temporal pattern. | 10-20-2011 |
20120194375 | ANALOG SIGNAL CONVERSION - An approach to converting an analog value based on a partition of an input range produces probabilities that the input is found within each of the regions based, for example, on a noisy version of the input. In some examples, iterative and/or pipelined application of comparison circuitry is used to accumulate a set of analog representations of the output probabilities. The circuitry can be adapted or configured according to the characteristics of the degradation (e.g., according to the variance of an additive noise) and/or prior information about the distribution of the clean input (e.g., a distribution over a discrete set of exemplar values, uniformly distributed etc.). | 08-02-2012 |
20120313802 | SIGNAL CONVERSION - An approach to signal conversion adapts the signal conversion process, for example, by adapting or configuring signal conversion circuitry, according to inferred characteristics (e.g., probability distribution of value) of a signal being converted. As an example, an analog-to-digital converter (ADC) may be adapted so that its accuracy varies across the range of possible input signal values in such a way that on average the digital signal provides a higher accuracy than had the accuracy remained fixed. In another example, models (and corresponding inference circuitry) of both an input signal process and of a quantization process are used to improve signal conversion accuracy. | 12-13-2012 |
20120317065 | PROGRAMMABLE PROBABILITY PROCESSING - In an aspect, in general, a programmable computation device performs computations of an inference task specified by a plurality of variables and a plurality of factors, each factor being associated with a subset of the variables. The device includes one or more processing elements. Each processing element includes a first storage for a definition of a factor, a second storage for data associated with the inputs and/or outputs of at least some of the computations, and one or more computation units coupled to the first storage and the second storage for performing a succession of parts of the at least some of the computations that are associated with a factor, the succession of parts defined by data in the storage for the definition of the factor. | 12-13-2012 |
20130094298 | STORAGE DEVICES WITH SOFT PROCESSING - A storage device includes a storage array having a group of storage elements. Each storage element can written to a discrete set of physical states. A read circuit selects one or more storage elements and generates, for each selected storage element, an analog signal representative of the physical state of the selected storage element. A signal processing circuit processes the analog signal to generate a plurality of outputs, with each output representing a degree of an association of the selected storage element with a different subset of one or more of the discrete set of physical states. | 04-18-2013 |
20140114443 | PROGRAMMABLE PROBABILITY PROCESSING - An inference task is performed using a computation device having a plurality of processing elements operable in parallel and connected via a connectivity system. Performing the task includes accepting at the device a specification of at least part of the inference task. The specification characterizes a plurality of variables and a plurality of factors, each factor being associated with a subset of the variables. Each of the processing elements is configured with data defining one or more of the plurality of factors. At each of the processing elements, computation associated with one of the factors is performed concurrently with other of the processing elements performing computation associated with different ones of the factors. Messages are exchanged via a connectivity system. The messages provide inputs and/or outputs to the processing elements for the computations associated with the factors and provide a result of performing of the at least the part of the inference task. | 04-24-2014 |
Jeffrey G. Bernstein, Middleton, MA US
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20160097846 | Systems and Methods for Ultrasound Beamforming - A system for ultrasound beamforming is provided, including a sampled analog beamformer, an array of ultrasound transducers, and a high voltage amplifier coupled to the sampled analog beamformer and the array of ultrasound transducers. The sampled analog beamformer includes a sampled analog filter for filtering an incoming analog signal and adding a fractional delay, and transmitting a filtered analog ultrasound signal. The array of ultrasound transducers further transmits the filtered analog ultrasound signal. The high voltage amplifier drives transducers in the array of ultrasound transducers. | 04-07-2016 |
Jonah Bernstein, Cambridge, MA US
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20140155980 | METHODS, DEVICES, AND SYSTEMS FOR POSTCONDITIONING WITH CLOT REMOVAL - New devices, systems, and methods are disclosed for preventing, treating, and/or at least minimizing ischemia and/or reperfusion injury by restoring and/or modulating blood flow, particularly in the cerebral vasculature where blood vessels are narrow and tortuous. These devices, systems, and methods make it possible for a clinician to adequately and systematically restore blood flow to ischemic tissue while simultaneously modulating the blood flow to minimize reperfusion injury. New thrombectomy devices and systems, which, for example, expand with greater radial force, further enable improved binding with clots and restoration of blood flow. | 06-05-2014 |
20150230820 | METHODS, DEVICES, AND SYSTEMS FOR POSTCONDITIONING WITH CLOT REMOVAL - New devices, systems, and methods are disclosed for preventing, treating, and/or at least minimizing ischemia and/or reperfusion injury by restoring and/or modulating blood flow, particularly in the cerebral vasculature where blood vessels are narrow and tortuous. These devices, systems, and methods make it possible for a clinician to adequately and systematically restore blood flow to ischemic tissue while simultaneously modulating the blood flow to minimize reperfusion injury. | 08-20-2015 |
Jonathan Bernstein, Medfield, MA US
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20080310001 | DEVICES, SYSTEMS AND METHODS FOR ACTUATING A MOVEABLE MINIATURE PLATFORM - An actuatable platform system may include a platform assembly coupled to a support element through a ball-and-socket joint. The system may also include a sensor for determining a position of the platform assembly. | 12-18-2008 |
20090027280 | MICRO-SCALE RESONANT DEVICES AND METHODS OF USE - The invention relates to micro-resonant devices (MRDs) that generate resonance at radio frequencies not present in an animal or human body, or present at low, background levels in the body. These individual, often monolithic devices, can be located in three-dimensional space and tracked anywhere in a target area, e.g., in a human or animal body, or within a cell within a body, using a conventional magnetic resonance imaging (MRI) scanner or other transducers, e.g., radiofrequency transducers. The MRDs generate high sensitivity contrast in conventional clinical MRI scanners, have a diameter of anywhere from a few nanometers to 1000 microns, and can in some embodiments be manufactured using Micro-Electro-Mechanical Systems (MEMS) technology. The devices are optionally coated to isolate them from the environment, and this coating can be a biocompatible coating for medical and biotechnology uses. | 01-29-2009 |
20090269536 | MULTI-COMPONENT ADHESIVE SYSTEM - Adhesive systems may be fabricated to include first and second solid adhesion structures. The first adhesion structure may require an applied normal preload force to achieve adhesion to a surface. The second solid adhesion structure may be separate from but joined to the first adhesion structure such that both adhesion structures are jointly adherable to the surface upon application of the normal preload force. | 10-29-2009 |
20090320606 | ACCESSIBLE STRESS-BASED ELECTROSTATIC MONITORING OF CHEMICAL REACTIONS AND BINDING - A sensor may include a substrate that has a cavity formed in a surface thereof. A diaphragm, having a conductive portion, may be suspended over the cavity, a selective coating may be present on a face of the diaphragm outside of the cavity, and a counterelectrode may be spaced from and in opposition to the diaphragm. The diaphragm may deform upon interaction of the selective coating with an analyte and thereby alter a capacitance of the sensor in a manner indicative of a degree of interaction. | 12-31-2009 |
20100067085 | SYSTEMS, METHODS AND DEVICES FOR ACTUATING A MOVEABLE MINIATURE PLATFORM - Presented herein are systems, methods and devices relating to miniature actuatable platform systems. According to one embodiment, the systems, methods, and devices relate to controllably actuated miniature platform assemblies including a miniature mirror. | 03-18-2010 |
20130104653 | MEMS HEMISPHERICAL RESONATOR GYROSCOPE | 05-02-2013 |
20130194770 | MEMS VIBRATION ISOLATION SYSTEM AND METHOD - A microelectromechanical vibration isolation system includes a microelectromechanical structure having a plurality of fin apertures etched therethrough, and a plurality of fins each disposed within a respective one of the plurality of fin apertures and spaced apart from the microelectromechanical structure so as to define a fluid gap therebetween. The fluid gap is configured to provide squeeze film damping of vibrations imparted upon the microelectromechanical structure in at least two dimensions. The system further includes a frame surrounding the microelectromechanical structure, and a plurality of springs each coupled to the microelectromechanical structure and to the frame. The plurality of springs is configured to support the micromechanical structure in relation to the frame. | 08-01-2013 |
Jonathan J. Bernstein, Medfield, MA US
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20100005884 | High Performance Sensors and Methods for Forming the Same - A sensor includes a proof mass suspended by a suspension beam, the suspension beam having a thickness less than a thickness of the proof mass. | 01-14-2010 |
20100171514 | MEMS DOSIMETER - In various embodiments, a dosimeter is employed to passively record a peak pressure (e.g., a peak blast pressure) and/or a maximum acceleration experienced by the dosimeter. | 07-08-2010 |
20110132088 | FLEXURE ASSEMBLIES AND METHODS FOR MANUFACTURING AND USING THE SAME - In one embodiment, an accelerometer includes a suspension frame, a proof mass, and a plurality of flexures suspending the proof mass from the suspension frame. The flexures allow the proof mass to deflect in response to an acceleration along a sensitive axis of the accelerometer. Each flexure exhibits an initial spring rate along the sensitive axis of substantially zero. | 06-09-2011 |
20110150667 | MEMS ELECTROSTATIC FLUIDIC PUMPS AND VALVES - In various embodiments, a pump is provided that includes a microfluidic channel and a plurality of electrodes for electrostatically translating a target fluid along the channel from an inlet to an outlet. In other embodiments, a valve includes a microfluidic channel, a reservoir in fluidic communication with the channel, and an electrode for electrostatically drawing a fluid from the reservoir into the channel so as to block the flow of other fluids through the channel. | 06-23-2011 |
20110247942 | ALKALI-METAL GENERATOR AND ABSORBER - Electrodes are positioned substantially in contact with at least one surface of a solid to generate or absorb alkali metals when a voltage is applied between the electrodes. | 10-13-2011 |
20120297871 | MEMS DOSIMETER - In various embodiments, a dosimeter is employed to passively record a peak pressure (e.g., a peak blast pressure) and/or a maximum acceleration experienced by the dosimeter. | 11-29-2012 |
20130021758 | Interconnect Schemes, and Materials and Methods for Producing the Same - An interconnect scheme includes a conductive ink forming a plurality of conductive regions, and a dielectric ink occupying spaces between the conductive regions. The conductive ink and the dielectric ink have substantially identical optical, acoustic, and x-ray absorption properties, thereby making the interconnect scheme tamper-resistant and/or difficult to identify and reverse-engineer using conventional detection methods. | 01-24-2013 |
20150126829 | MICRO-MAGNETIC REPORTER AND SYSTEMS - The present disclosure describes system and methods for detecting and amplifying weak magnetic fields generated by anatomical structures. The disclosure describes an implantable magnetic reporter system. The magnetic reporter system includes a magnetic reporter. The magnetic reporter includes a platform coupled to a support structure by a plurality of torsional flexures. A magnet is disposed on the platform, and the magnet and platform rotate when exposed to a magnetic field. The rotation of the magnet generates a stronger magnet field that is detectable external to the patient. | 05-07-2015 |
Michael Bernstein, Cambridge, MA US
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20110153595 | System And Method For Identifying Topics For Short Text Communications - A system and method for identifying topics for short text communications is provided. Tokens are extracted from a short text communication. A query is generated using the extracted tokens. The query is applied to a set of documents. Those documents in the set that match the query are identified as search results. Salient terms associated with each of the search results are identified. A threshold is applied to the identified salient terms. The salient terms that satisfy the threshold are selected as topics for the short text communication. | 06-23-2011 |
Steven D. Bernstein, Brighton, MA US
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20100090228 | BORON ALUMINUM NITRIDE DIAMOND HETEROSTRUCTURE - A heterostructure having a heterojunction comprising: a diamond layer; and a boron aluminum nitride (B | 04-15-2010 |
20100155900 | FABRICATING A GALLIUM NITRIDE DEVICE WITH A DIAMOND LAYER - In one aspect, a method includes fabricating a device. The device includes a gallium nitride (GaN) layer, a diamond layer disposed on the GaN layer and a gate structure disposed in contact with the GaN layer and the diamond layer. | 06-24-2010 |
20100155901 | FABRICATING A GALLIUM NITRIDE LAYER WITH DIAMOND LAYERS - In one aspect, a method includes fabricating a gallium nitride (GaN) layer with a first diamond layer having a first thermal conductivity and a second diamond layer having a second thermal conductivity greater than the first thermal conductivity. The fabricating includes using a microwave plasma chemical vapor deposition (CVD) process to deposit the second diamond layer onto the first diamond layer. | 06-24-2010 |
20100187544 | FABRICATING A GALLIUM NITRIDE LAYER WITH DIAMOND LAYERS - In one aspect, a method includes fabricating a gallium nitride (GaN) layer with a first diamond layer having a first thermal conductivity and a second diamond layer having a second thermal conductivity greater than the first thermal conductivity. The fabricating includes using a microwave plasma chemical vapor deposition (CVD) process to deposit the second diamond layer onto the first diamond layer. | 07-29-2010 |
20110032678 | NANO-TUBE THERMAL INTERFACE STRUCTURE - A structure, comprising: a semiconductor structure having an electrically and thermally conductive layer disposed on one surface of the semiconductor structure; an electrically and thermally conductive heat sink; a electrically and thermally conductive carrier layer; a plurality of electrically and thermally nano-tubes, a first portion of the plurality of nano-tubes having proximal ends disposed on a first surface of the carrier layer and a second portion of the plurality of nano-tubes having proximal ends disposed on an opposite surface of the carrier layer; and a plurality of electrically and thermally conductive heat conductive tips disposed on distal ends of the plurality of nano-tubes, the plurality of heat conductive tips on the first portion of the plurality of nano-tubes being attached to the conductive layer, the plurality of heat conductive tips on the second portion of the plurality of nano-tubes being attached to the heat sink. | 02-10-2011 |
20110241018 | FABRICATING A GALLIUM NITRIDE DEVICE WITH A DIAMOND LAYER - In one aspect, a method includes fabricating a device. The device includes a gallium nitride (GaN) layer, a diamond layer disposed on the GaN layer and a gate structure disposed in contact with the GaN layer and the diamond layer. | 10-06-2011 |
20120094484 | NANO-TUBE THERMAL INTERFACE STRUCTURE - A structure, comprising: a semiconductor structure having an electrically and thermally conductive layer disposed on one surface of the semiconductor structure; an electrically and thermally conductive heat sink; a electrically and thermally conductive carrier layer; a plurality of electrically and thermally nano-tubes, a first portion of the plurality of nano-tubes having proximal ends disposed on a first surface of the carrier layer and a second portion of the plurality of nano-tubes having proximal ends disposed on an opposite surface of the carrier layer; and a plurality of electrically and thermally conductive heat conductive tips disposed on distal ends of the plurality of nano-tubes, the plurality of heat conductive tips on the first portion of the plurality of nano-tubes being attached to the conductive layer, the plurality of heat conductive tips on the second portion of the plurality of nano-tubes being attached to the heat sink. | 04-19-2012 |
20160087536 | STACKED POWER CONVERTER ASSEMBLY - A stacked magnetic power converter assembly includes a plurality of converter modules disposed in a stacked arrangement with respect to one another to define a thickness of stacked magnetic power converter assembly. Each converter module includes a primary switching unit, a secondary switching unit, and a converter unit. The converter unit includes a primary terminal in signal communication with the primary switching unit and a secondary terminal in signal communication with the secondary switching unit. Each primary switching unit, each secondary switching unit, and each converter unit is shared among the plurality of converter modules. | 03-24-2016 |