Parker, MA
Alexander N. Parker, Boston, MA US
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20150046180 | SYSTEM AND METHOD FOR MANAGING GENOMIC INFORMATION - Various embodiments provide interfaces to access genomic testing information and incorporate it into daily physician practice. According to one aspect, a graph-based data model is used that may be used to organizes and revise precision medicine knowledge. In one example structure, gene states are abstracted into alteration groups, where alteration groups are built using reverse engineering actionable information and storing that information within the graph-based data structure. Volumes of genomic alterations and associated information (e.g., journal articles, clinical trial information, therapies, etc.) are analyzed and synthesized into actionable information items viewable on an alteration system in a graph-based data format. According to one embodiment, the system can be configured to focus practitioners on discrete portions of the alteration information on which they can act. According to other aspects, curated information is provided on the system to enable practitioners to make informed decisions regarding the implications of the presence of specific genomic alterations. | 02-12-2015 |
20150046191 | SYSTEM AND METHOD FOR MANAGING GENOMIC INFORMATION - Various embodiments provide interfaces to access genomic testing information and incorporate it into daily physician practice. According to one aspect, a graph-based data model is used that may be used to organizes and revise precision medicine knowledge. In one example structure, gene states are abstracted into alteration groups, where alteration groups are built using reverse engineering actionable information and storing that information within the graph-based data structure. Volumes of genomic alterations and associated information (e.g., journal articles, clinical trial information, therapies, etc.) are analyzed and synthesized into actionable information items viewable on an alteration system in a graph-based data format. According to one embodiment, the system can be configured to focus practitioners on discrete portions of the alteration information on which they can act. According to other aspects, curated information is provided on the system to enable practitioners to make informed decisions regarding the implications of the presence of specific genomic alterations. | 02-12-2015 |
Alexander N. Parker, West Roxbury, MA US
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20120208706 | OPTIMIZATION OF MULTIGENE ANALYSIS OF TUMOR SAMPLES - A method of analyzing a tumor sample comprising: | 08-16-2012 |
20140243390 | NOVEL KIF5B-RET FUSION MOLECULES AND USES THEREOF - Novel RET fusion molecules and uses are disclosed. | 08-28-2014 |
Amdrew Parker, Cambridge, MA US
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20130179567 | Network performance monitoring in a content delivery system - A method for Internet delivery in a delivery network established at network locations, the delivery network comprising a plurality of content servers for serving resources. The servers include a plurality of subsets, each subset being located at one of a plurality of Internet data centers. For each Internet Protocol (IP) address block from which requests for content resources are expected to be received, the method generates a candidate list of data centers to be used to service the requests. For the IP address block, the method selects at least one of the data centers from the candidate list. The selected Internet data center for the IP address block is written into a network map. In response to a DNS query, the map is used to identify one of the Internet data centers from the candidate list to be used to service a request for a content resource. | 07-11-2013 |
Andrew Parker, Cambridge, MA US
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20100217801 | Network performance monitoring in a content delivery system - A method for Internet content delivery in a content delivery network established at network locations, the content delivery network comprising a plurality of content servers for serving content resources. The plurality of content servers includes a plurality of subsets of content servers, each subject being located at one of a plurality of Internet data centers. For each Internet Protocol (IP) address block from which requests for content resources are expected to be received, the method generates a candidate list of Internet data centers to be used to service the requests for content resources. For the IP address block, the method selects at least one of the Internet data centers from the candidate list to be used to service the requests for content resources. The selected Internet data center for the IP address block is written into a network map. The selecting step is carried out concurrently for each IP address block from which requests for content resources are expected to be received such that the network map comprises the selected Internet data center for each IP address block. The network map is then provided to a domain name service (DNS) associated with the content delivery network. In response to a DNS query received at the domain name service associated with the content delivery network, the network map is used to identify one of the Internet data centers from the candidate list to be used to service a request for a content resource. | 08-26-2010 |
Clifford W. Parker, New Ipswich, MA US
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20080318150 | Paper Compositions, Imaging Methods and Methods for Manufacturing Paper - Paper compositions are provided that include an amine group-containing cationic polymeric material and a binder material. The paper compositions are particularly useful as receiver materials for images formed by electrophotographic imaging methods utilizing liquid developers. Also described are imaging methods that utilize the paper compositions as receiver materials and methods for manufacturing the paper. | 12-25-2008 |
Coleman P. Parker, Watertown, MA US
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20090293106 | METHOD AND APPARATUS FOR CONTROLLING WIRELESS NETWORK ACCESS PRIVILEGES BASED ON WIRELESS CLIENT LOCATION - An access point through which a wireless device attaches to a wireless network determines the access privileges that will be accorded to the device based on a criteria set, such as the ID and physical location of the device requesting network access, the access point through which the device is connected to the network and user credentials. The location of the device is determined by a location determination system using the signal strength of the device signal. The location information and ID information is provided to an access server that uses the criteria set to retrieve access privileges from a privilege database. The retrieved access privileges are then applied to the wireless device by means of the access point and other devices in the wireless network. | 11-26-2009 |
Coleman P. Parker, Framingham, MA US
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20150314440 | Robotic Control System Using Virtual Reality Input - A robotic system and method performs tasks autonomously on real-world objects (RWOs) upon receipt of inputs from a virtual reality environment. A robotic actuator has tools to manipulate the RWOs, and a set of robot-specific instructions for actuating the tools. A first set of rules governs the RWOs, and sensors detect the presence of the RWOs. A virtual reality (VR) computer uses sensor data to generate a virtual world (VW) including virtual world objects (VWOs) representative of RWOs. A second set of rules governs the VWOs. A user manipulates the VWOs to generate a modified virtual world (MVW). A transformation engine captures differences between the VW and MVW, transforms the differences into inputs for the robotic actuator. An autonomous instruction engine receives the inputs to identify RWOs and combines the inputs with the first set of rules to generate combined instructions usable by the robotic actuator to manipulate RWOs autonomously. | 11-05-2015 |
David Thomas Parker, Lexington, MA US
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20090137495 | Organic Compounds and Their Uses - The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of human diseases. | 05-28-2009 |
20100120872 | ORGANIC COMPOUNDS AND THEIR USES - The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of human diseases. | 05-13-2010 |
20100204159 | ORGANIC COMPOUNDS AND THEIR USES - The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of human diseases. | 08-12-2010 |
20100240638 | Organic Compounds and their uses - The present application describes macrocyclic compounds of formula (I) with NS3 protease inhibitory activity for treating hepatitis C virus infection. | 09-23-2010 |
20100331243 | ORGANIC COMPOUNDS AND THEIR USES - The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of human diseases. | 12-30-2010 |
20120231998 | ORGANIC COMPOUNDS AND THEIR USES - The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of human diseases. | 09-13-2012 |
20130149281 | ORGANIC COMPOUNDS AND THEIR USES - The present application describes a method of treating an HCV-associated disorder by administering to a subject in need thereof a pharmaceutically effective amount of a compound of formula I in combination with an additional HCV-modulating compound. | 06-13-2013 |
David Thomas Parker, Cambridge, MA US
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20110275819 | ORGANIC COMPOUNDS AND THEIR USES - The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of human diseases. | 11-10-2011 |
David Vickery Parker, Medford, MA US
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20120272663 | CENTRIFUGAL COMPRESSOR ASSEMBLY WITH STATOR VANE ROW - A compressor assembly for a gas turbine engine includes rotatable impeller with forward and aft ends, including: an annular hub defining a generally concave-curved cross-sectional inner flowpath surface at its radially outer periphery, the inner flowpath surface extending between an inlet and an exit; an annular array of airfoil-shaped inducer blades extending radially outward from the inner flowpath surface near the forward end; and an annular array of exducer blades extending outward from the inner flowpath surface, the array of exducer blades axially spaced apart from the array of inducer blades; a non-rotating shroud assembly surrounding the impeller and including a convex-curved outer flowpath surface, wherein the inner and outer flowpath surfaces cooperate to define a primary flowpath past the blades and the stator vanes; and an annular array of airfoil-shaped stator vanes extending radially inward from the outer flowpath surface into a space between the inducer and exducer blades. | 11-01-2012 |
20140140822 | Contoured Stator Shroud - A contoured stator shroud has a stator chord overhang having a surface which varies in elevation forming a plurality of surface contours, wherein the contours reduce clearance between adjacent vanes during off design performance positioning of the vanes. | 05-22-2014 |
David Vickery Parker, Lynn, MA US
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20160123227 | SEPARATOR ASSEMBLY FOR A GAS TURBINE ENGINE - A separator assembly for removing entrained particles from a fluid stream passing through a gas turbine engine includes a first particle separator for separating the fluid stream into a reduced-particle stream and a particle-laden stream, and emitting the particle-laden stream through a scavenge outlet. Another particle remover is fluidly coupled to the scavenge outlet to remove more particles from the air stream. | 05-05-2016 |
David Vickery Parker, Middleton, MA US
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20160123154 | ENGINE COMPONENT FOR A TURBINE ENGINE - An engine component for a turbine engine includes a particle collector having a substrate configured to retain at least some particles from a particle-laden stream passing through a portion of the engine. A fluid bypass around the substrate of the collector enables the particle-laden stream to bypass the substrate if the substrate is filled with particles. | 05-05-2016 |
Donald M. Parker, Marblehead, MA US
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20100159343 | Gas Storage System - Among other things, a gas storage system includes a group of capsules and an activation element coupled to the group. The group of capsules are formed within a substrate and contain gas stored at a relatively high pressure compared to atmospheric pressure. The activation element is configured to deliver energy in an amount sufficient to cause at least one of the capsules to release stored gas. | 06-24-2010 |
20120280179 | Self-Regulating Gas Generator and Method - A self-regulating gas generator that, in response to gas demand, supplies and automatically adjusts the amount of gas (e.g., hydrogen or oxygen) catalytically generated in a chemical supply chamber from an appropriate chemical supply, such as a chemical solution, gas dissolved in liquid, or mixture. In some embodiments, the gas generator may employ a piston, rotating rod, or other element(s) to expose the chemical supply to the catalyst in controlled amounts. In another embodiment, the self-regulating gas generator uses bang-bang control, with the element(s) exposing a catalyst, contained within the chemical supply chamber, to the chemical supply in ON and OFF states according to a self-adjusting duty cycle, thereby generating and outputting the gas in an orientation-independent manner. The gas generator may be used to provide gas for various gas consuming devices, such as a fuel cell, torch, or oxygen respiratory devices. | 11-08-2012 |
20130295002 | SELF-REGULATING GAS GENERATOR AND METHOD - A self-regulating gas generator that, in response to gas demand, supplies and automatically adjusts the amount of gas (e.g., hydrogen or oxygen) catalytically generated in a chemical supply chamber from an appropriate chemical supply, such as a chemical solution, gas dissolved in liquid, or mixture. In some embodiments, the gas generator may employ a piston, rotating rod, or other element(s) to expose the chemical supply to the catalyst in controlled amounts. In another embodiment, the self-regulating gas generator uses bang-bang control, with the element(s) exposing a catalyst, contained within the chemical supply chamber, to the chemical supply in ON and OFF states according to a self-adjusting duty cycle, thereby generating and outputting the gas in an orientation-independent manner. The gas generator may be used to provide gas for various gas consuming devices, such as a fuel cell, torch, or oxygen respiratory devices. | 11-07-2013 |
20140045089 | Gas Storage System - Among other things, a gas storage system includes a group of capsules and an activation element coupled to the group. The group of capsules are formed within a substrate and contain gas stored at a relatively high pressure compared to atmospheric pressure. The activation element is configured to deliver energy in an amount sufficient to cause at least one of the capsules to release stored gas. | 02-13-2014 |
Donald Merrill Parker, Marblehead, MA US
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20130112550 | High Pressure Gas System - Among other things, a device for use in electrolyzing water is described. The device comprises an electrolysis unit that includes a chamber, an ion exchange structure in the chamber, a cathode, an anode, a high pressure chamber, and a reservoir. The chamber is separated by the ion exchange structure into a first compartment and a second compartment. The cathode is in the first compartment and the anode in the second compartment. The reservoir is disposed in the high pressure chamber for storing water to be supplied to the chamber of the electrolysis unit. In some implementations, the ion exchange structure is a proton exchange membrane. | 05-09-2013 |
Jason Christopher Parker, Graftou, MA US
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20130111641 | BALLISTIC AND BLUNT IMPACT PROTECTIVE KNEE AND ELBOW PADS - A light-weight protective pad for an elbow or a knee providing both ballistic and blunt impact protection is disclosed. The pad has a rigid light weight composite cup removably attached to the outer surface of an abrasion resistant cover fabric. The cover fabric contains a thermally formed armor cup providing ballistic protection and a foam layer to aid in absorption of blunt impacts. The inner surface of the pad is lined with felt. | 05-09-2013 |
Jeffrey James Parker, Millis, MA US
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20100039532 | In Flight Autofocus System And Method - A camera module and method for focusing a tunable lens configured to continuously vary its optical power in response to a drive signal. A drive circuit generates the drive signal so that the tunable lens performs a continuous scan of its optical power. An image sensor is configured to acquire light images passing through the tunable lens, and to convert the light images to image signals during the continuous scan. A processor is configured to generate focus scores of the acquired light images using the image signals during the continuous scan. The processor is configured to determine from the focus scores a peak focus score achieved or achievable, and to instruct the drive circuit to adjust the drive signal so that the tunable lens settles at a value of the optical power that corresponds to the peak focus score. | 02-18-2010 |
20140049682 | IN-FLIGHT AUTO FOCUS METHOD AND SYSTEM FOR TUNABLE LIQUID CRYSTAL OPTICAL ELEMENT - An auto-focus system employing a tunable liquid crystal lens is provided that collects images at different optical power values as the liquid crystal molecules are excited between a ground state and a maximum optical power state tracking image focus scores. An image is acquired at a desired optical power value less than maximum optical power established with the liquid crystal molecules closer a fully excited state than the maximum optical power state having the same image focus score. This drive signal employed during image acquisition uses more power than was used to achieve the same optical power value during the auto-focus scan, while actively driving the liquid crystal molecules is fast. A pause due to image transfer/processing delays after acquisition is employed to allow slow relaxation of the liquid crystal molecules back to the ground state in preparation for a subsequent focus search. | 02-20-2014 |
20150301307 | IN-FLIGHT AUTO FOCUS METHOD AND SYSTEM FOR TUNABLE LIQUID CRYSTAL OPTICAL ELEMENT - An auto-focus system employing a tunable liquid crystal lens is provided that collects images at different optical power values as the liquid crystal molecules are excited between a ground state and a maximum optical power state tracking image focus scores. An image is acquired at a desired optical power value less than maximum optical power established with the liquid crystal molecules closer a fully excited state than the maximum optical power state having the same image focus score. This drive signal employed during image acquisition uses more power than was used to achieve the same optical power value during the auto-focus scan, while actively driving the liquid crystal molecules is fast. A pause due to image transfer/processing delays after acquisition is employed to allow slow relaxation of the liquid crystal molecules back to the ground state in preparation for a subsequent focus search. | 10-22-2015 |
Jeffrey Stuart Parker, Quincy, MA US
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20130014395 | RAZOR BLADES HAVING A LARGE TIP RADIUS - A razor blade including a substrate with a coating joined to the substrate defining a coated blade. The coated blade including a cutting edge being defined by a blade tip having a tip radius of from 500 to 1500 angstroms. The coated blade having a thickness of between 0.3 and 0.5 micrometers measured at a distance of 0.25 micrometers from the blade tip, a thickness of between 0.4 and 0.65 micrometers measured at a distance of 0.5 micrometers from the blade tip, a thickness of between 0.61 and 0.71 micrometers measured at a distance of 1 micrometer from the blade tip, a thickness of between 0.96 and 1.16 micrometers measured at a distance of 2 micrometers from the blade tip, and a thickness of between 1.56 and 1.91 micrometers measured at a distance of 4 micrometers from the blade tip. | 01-17-2013 |
20130014396 | RAZOR BLADES HAVING A WIDE FACET ANGLE - A razor blade including a substrate with a coating joined to the substrate defining a coated blade. The coated blade including a cutting edge being defined by a blade tip having a tip radius of from 50 to 350 angstroms. The coated blade having a pair of first facets extending from the blade tip and a pair of second facets extending from the respective first facets, a facet angle from 90° to 135°, a facet width from 0.38 micrometers to 0.65 micrometers a wedge angle from 5° to 30°, and a thickness of between 0.8 and 1.5 micrometers measured at a distance of 1 micrometer from the blade tip. | 01-17-2013 |
20130031794 | RAZOR BLADES WITH ALUMINUM MAGNESIUM BORIDE (AlMgB14)-BASED COATINGS - This invention relates to a novel application of hard, low friction aluminum magnesium boride (AlMgB | 02-07-2013 |
Jeremy Parker, Chelmsford, MA US
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20160142829 | INTEGRATED PACKAGE FORMING WIDE SENSE GAP MICRO ELECTRO-MECHANICAL SYSTEM MICROPHONE AND METHODOLOGIES FOR FABRICATING THE SAME - A micro electro-mechanical system (MEMS) microphone is provided. The microphone includes: a package substrate having a port disposed through the package substrate, wherein the port is configured to receive acoustic waves; and a lid coupled to the substrate and forming a package. The MEMS microphone also includes a MEMS acoustic sensor disposed in the package and positioned such that the acoustic waves receivable at the port are incident on the MEMS acoustic sensor. The MEMS acoustic sensor includes: a back plate positioned over the port at a first location within the package; and a diaphragm positioned at a second location within the package, wherein a distance between the first location and the second location forms a defined sense gap, and wherein the MEMS microphone is designed to withstand a bias voltage between the diaphragm and the back plate greater than or equal to about 15 volts. | 05-19-2016 |
Justin L. Parker, Billerica, MA US
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20110151703 | Solar panel grounding connector - An electrical connector including a first section adapted to receive a first electrical conductor; a second section, and a rotatable connection between the first and second section. The second section has a channel adapted to receive a portion of a frame of a solar panel. The second section is adapted to spring clip onto the solar panel frame and make an electrical connection therewith. The rotatable connection is adapted to rotate the first section relative to the second section to orient the first electrical conductor at a desired orientation relative to the solar panel. | 06-23-2011 |
Justin Lloyd Parker, Billerica, MA US
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20090313820 | Crimping Tool Connector Locator - Disclosed herein is a hydraulic tool working head guide. The hydraulic tool working head guide includes a main section having a general plate shape. The main section is adapted to be connected to an exterior surface of a hydraulic tool working head. The main section includes a slot having an open end at an edge of the main section and a closed end at a middle portion of the main section. The slot extends through a thickness of the main section. The closed end is adapted to be aligned with a receiving area of the hydraulic tool working head. The slot is adapted to substantially center a connector and/or a conductor in the receiving area. | 12-24-2009 |
Karin Averill Parker, Agawam, MA US
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20110138107 | USB NON-VOLATILE MEMORY SYSTEM FOR AN ELECTRONIC ENGINE CONTROLLER - An electronic engine controller has a processor, a data controller, and a non-volatile memory. During an engine operation, power is supplied to the processor, data controller, and non-volatile memory from an engine power source. Sensor data is received at the processor which supplies the sensor data to the data controller. The data controller stores the sensor data in the non-volatile memory. During data retrieval, power is supplied to the data controller and the non-volatile memory from a USB communications channel. The data controller retrieves the saved sensor data from the non-volatile memory and provides it to the USB communications channel. | 06-09-2011 |
Kevin Parker, Waltham, MA US
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20150253307 | POLYMERIC FIBER-SCAFFOLDED ENGINEERED TISSUES AND USES THEREOF - The present invention provides devices, constructs, and methods of use of polymeric fiber-scaffolded engineered tissues and assays for identifying compounds that modulate a contractile function, using such devices and constructs. | 09-10-2015 |
Kevin Kit Parker, Waltham, MA US
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20100330644 | BOUNDARY CONDITIONS FOR THE ARRANGEMENT OF CELLS AND TISSUES - The present invention relates to the arrangement of one or more cells in a medium or on a substrate through the use of boundary conditions, which are changes in local environment compared to the medium or substrate alone or cause an alteration of cell response upon interaction of a cell with the boundary condition. | 12-30-2010 |
20120027807 | TISSUE ENGINEERED MYOCARDIUM AND METHODS OF PRODUCTION AND USES THEREOF - The present invention generally relates to a population of committed ventricular progenitor (CVP) cells and their use to generate a tissue engineered myocardium, in particular two dimensional tissue engineered myocardium which is comparable to functional ventricular heart muscle. One embodiment of present invention provides a composition and methods for the production of a tissue engineered myocardium which has functional properties of cardiac muscle, such as contractibility (e.g. contraction force) and numerous properties of mature fully functional ventricular heart muscle tissue. In particular, in one embodiment, a composition comprising the tissue engineered myocardium comprises committed ventricular progenitor (CVP) cells seeded on a free-standing biopolymer structure to form functional ventricular myocardium tissue. | 02-02-2012 |
20120029416 | POROUS ELECTROACTIVE HYDROGELS AND USES THEREOF - The present invention provides porous electroactive hydrogels, the deformation angle of which is controlled by electroactuation, and methods for preparing and using such hydrogels. | 02-02-2012 |
20120135448 | METHODS AND DEVICES FOR THE FABRICATION OF 3D POLYMERIC FIBERS - The present invention provides methods and devices for the fabrication of 3D polymeric fibers having micron, sub-micron, and nanometer dimensions, as well as methods of use of these polymeric fibers. | 05-31-2012 |
20120142556 | HIGH THROUGHPUT ASSAYS FOR DETERMINING CONTRACTILE FUNCTION AND DEVICES FOR USE THEREIN - The present invention provides high throughput assays for identifying compounds that modulate a contractile function, as well as devices suitable for use in these assays. | 06-07-2012 |
20130037419 | ELECTROMECHANICAL SYSTEMS INCLUDING BIOCHEMICAL ACTUATOR HEADS - Disclosed herein are biochemical actuator heads instrumented with a receptor conductive polymer for reversibly controlling ligand-receptor interactions. Also disclosed are systems and methods for utilizing and fabricating the biochemical actuator head. The biochemical actuator head and related systems and methods may be used in a wide array of applications including, without limitation, micro/nano assembly, examination of cellular signaling mechanisms, image-guided cell nanosurgery or particle processing. Particle processing systems and methods are also provided utilizing a receptor conductive polymer for reversibly controlling ligand-receptor interactions. | 02-14-2013 |
20130046134 | METHODS OF GENERATING ENGINEERED INNERVATED TISSUE AND USES THEREOF - The present invention provides methods for generating relevant in vitro models of engineered innervated tissue, as well as uses of such tissues. | 02-21-2013 |
20130312638 | SYSTEMS, DEVICES AND METHODS FOR THE FABRICATION OF POLYMERIC FIBERS - Exemplary embodiments provide systems, devices and methods for the fabrication of three-dimensional polymeric fibers having micron, submicron, and nanometer dimensions, as well as methods of use of the polymeric fibers. | 11-28-2013 |
20130330378 | ANISOTROPIC BIOLOGICAL PACEMAKERS AND AV BYPASSES - The present invention provides biological pacemakers or AV-node bypasses The biological pacemakers or AV-node bypasses of the invention are useful for the treatment of, inter alia, cardiac arrhythmias and AV-node conduction defects. | 12-12-2013 |
20140236267 | PHOTOSENSITIVE CARDIAC RHYTHM MODULATION SYSTEMS - Photosensitive cardiac rhythm modulation structures and systems are described. A genetically-engineered tissue comprising a population of pacing cells expressing a photosensitive membrane transport mechanism that is responsive to light of a particular wavelength(s) combined with one or more of a light source, a power generator, and a sensor provides pacemaker and/or defibrillator function to a subject. The systems further provide in vitro model systems for electrophysiological studies. | 08-21-2014 |
20140322515 | SYSTEMS, DEVICES AND METHODS FOR FABRICATION OF POLYMERIC FIBERS - In accordance with an exemplary embodiment, a method is provided for forming a micron, submicron and/or nanometer dimension polymeric fiber. The method includes providing a stationary deposit of a polymer. The method also includes contacting a surface of the polymer to impart sufficient force in order to decouple a portion of the polymer from the contact and to fling the portion of the polymer away from the contact and from the deposit of the polymer, thereby forming a micron, submicron and/or nano-meter dimension polymeric fiber. | 10-30-2014 |
20140342394 | MUSCLE CHIPS AND METHODS OF USE THEREOF - The present invention provides high throughput assays for identifying compounds that modulate a contractile function, as well as devices suitable for these assays. | 11-20-2014 |
20140342445 | ORGAN CHIPS AND USES THEREOF - Disclosed herein are organ chips that can be individually used or integrated together to form different microphysiological systems, e.g., for use in cell culturing, drug screening, toxicity assays, personalized therapeutic treatment, scaffolding in tissue repair and/or replacement, and/or pharmacokinetic or pharmacodynamics studies. | 11-20-2014 |
Kevin Kit Parker, Watham, MA US
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20140004553 | ENGINEERED CELL GROWTH ON POLYMERIC FILMS AND BIOTECHNOLOGICAL APPLICATION THEREOF | 01-02-2014 |
Kevin Kit Parker, Cambridge, MA US
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20090142303 | METHODS AND COMPOSITIONS FOR DRIED CELLULAR FORMS - Methods and compositions of spray drying cellular material are provided that allow preservation of the cellular material. In one aspect, the cellular material is spray dried with a quantity of excipient. In another aspect, the cellular material is spray dried using a cryoprotectant. | 06-04-2009 |
20090317852 | Engineered Cell Growth on Polymeric Films and Biotechnological Applications Thereof - A free-standing thin film is fabricated from a structure comprising a base layer coated with a sacrificial polymer layer, which is in turn coated with a flexible polymer layer. Cells are then seeded onto the flexible polymer layer and cultured to form a tissue. The flexible polymer layer is then released from the base layer to produce a free-standing thin film comprising the tissue on the flexible polymer layer. In one embodiment, the cells are myocytes, which can be actuated to propel or displace the free-standing film. In another embodiment, the free-standing film is used to treat injured human tissue. | 12-24-2009 |
20100191083 | ENGINEERED CONDUCTIVE POLYMER FILMS TO MEDIATE BIOCHEMICAL INTERACTIONS - The conductive polymer films of this disclosure reversibly and selectively mediate ligand-receptor interactions. This electrochemical manipulation of biochemical interactions is accomplished by embedding or adsorbing receptors for ligands of interest in or onto a conductive polymer matrix. The matrix can also be doped, for example, with desired ions, polyions, or surfactants. Depending on the receptor properties and dopants utilized, ligand-receptor interactions at the polymer-electrolyte interface are manipulated by controlling the oxidation and reduction of the conductive polymer. The intrinsic charge transfer characteristics of conductive polymers are used to modulate ligand-receptor interactions. | 07-29-2010 |
20100196432 | BIOPOLYMER STRUCTURES - The invention described herein relates to biopolymer structures. The biopolymer structures are spatially organized from the nanometer to centimeter length scales and incorporate functionally active cells. Applications of the biopolymer structures include use with stem cells. | 08-05-2010 |
20110189719 | METHODS OF GENERATING PATTERNED SOFT SUBSTRATES AND USES THEREOF - The present invention provides methods of generating and devices of patterned soft substrates, on which cells may be seeded, as well as methods of using these substrates. Devices containing these patterned soft substrates are also provided. | 08-04-2011 |
20150158911 | PIGMENT STRUCTURES, PIGMENT GRANULES, PIGMENT PROTEINS, AND USES THEREOF - The present invention is based, at least in part, on the isolation of intact pigment granules from the brown chromatophores in the skin of the cuttlefish, | 06-11-2015 |
20150182679 | TISSUE-ENGINEERED PUMPS AND VALVES AND USES THEREOF - The present invention provides tissue-engineered pumps and valves, methods of fabricating such pumps and valves, and methods of use of such pumps and valves. | 07-02-2015 |
20150253307 | POLYMERIC FIBER-SCAFFOLDED ENGINEERED TISSUES AND USES THEREOF - The present invention provides devices, constructs, and methods of use of polymeric fiber-scaffolded engineered tissues and assays for identifying compounds that modulate a contractile function, using such devices and constructs. | 09-10-2015 |
20150329604 | PIGMENT STRUCTURES, PIGMENT GRANULES, PIGMENT PROTEINS, AND USES THEREOF - The present invention provides synthetic pigment structures, isolated pigment granules, and pigment proteins, as well as methods of making and using them. | 11-19-2015 |
20150354094 | IMMERSED ROTARY JET SPINNING DEVICES (IRJS) AND USES THEREOF - Exemplary embodiments provide systems, devices and methods for the fabrication of three-dimensional polymeric fibers having micron, submicron and nanometer dimensions, as well as methods of use of the polymeric fibers. | 12-10-2015 |
20160000886 | NANOSTRUCTURED ACTIVE THERAPEUTIC VEHICLES AND USES THEREOF - The present invention provides nano structured active therapeutic vehicles which include a biodegradable polymeric fiber and/or thread comprising a porous particle which encapsulates an active agent. The vehicles of the present invention may be used to provide sustained release of the active agent to a subject. | 01-07-2016 |
20160003806 | HIGH THROUGHPUT ASSAYS FOR DETERMINING CONTRACTILE FUNCTION AND DEVICES FOR USE THEREIN - The present invention provides high throughput assays for identifying compounds that modulate a contractile function, as well as devices suitable for use in these assays. | 01-07-2016 |
Mark A. Parker, Brighton, MA US
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20140134136 | COMPOSITIONS AND METHODS FOR AUDITORY THERAPY - The invention provides compositions for inducing expression in hair cells, and provides methods of using these compositions for modulating cochlear expression. Such compositions are further useful in treatment of sensorineural hearing loss, e.g., increasing proliferation or survival of mechanosensory hair cells. | 05-15-2014 |
Peter A. Parker, Billerica, MA US
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20100226454 | Method and apparatus for synchronizing a wireless communication system - Techniques for synchronizing a receiver and transmitter in a wireless communication system address synchronization within the context of a detection formulation and provide synchronization statistics used to declare a synchronization detection. A signal is received from a channel at multiple receiving antennas. The receiver and transmitter are synchronized based on the received signal and a channel model incorporating the multiple receiving antennas. The channel model may also incorporate a resolvable delay spread of the received signal with respect to each receiving antenna. Synchronization may be based on a known component of a received signal and further on a channel model incorporating multiple receiving antennas and an interference signal. The known component may be a cyclic prefix or a pilot sequence as in orthogonal frequency division multiplexing (OFDM). | 09-09-2010 |
Robert Parker, Seekonk, MA US
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20150231763 | Shot Material and Shot Peening Method - A method of shot peening a workpiece comprising projecting metal alloy particles at a workpiece wherein said metal alloy particles comprises Fe in combination with B, C, Cr and Nb, wherein the Fe is present at a level of greater than 50.0 atomic percent. The metal alloy particles have a Vickers Hardness (HV) of at least 1150 and an elastic modulus of greater than 200 GPa. | 08-20-2015 |
Robert P. Parker, Westborough, MA US
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20100092019 | WAVEGUIDE ELECTROACOUSTICAL TRANSDUCING - A waveguide system for radiating sound waves. The system includes a low loss waveguide for transmitting sound waves, having walls are tapered so that said cross-sectional area of the exit end is less than the cross-sectional area of the inlet end. In a second aspect of the invention, a waveguide for radiating sound waves, has segments of length approximately equal to | 04-15-2010 |
Ronald Parker, Boxborough, MA US
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20100195602 | Application, Usage & Radio Link Aware Transport Network Scheduler - A packet scheduling method and apparatus with the knowledge of application behavior, anticipated usage/behavior based on the type of content, and underlying transport conditions during the time of delivery, is disclosed. This type of scheduling is applicable to a content server or a transit network device in wireless (e.g., 3G, WIMAX, LTE, WIFI) or wire-line networks. Methods for identifying or estimating rendering times of multi-media objects, segmenting a large media content, and automatically pausing or delaying delivery are disclosed. The scheduling reduces transit network bandwidth wastage, and facilitates optimal sharing of network resources such as in a wireless network. | 08-05-2010 |
Ronald Parker, Belmont, MA US
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20100102828 | SYSTEM AND METHOD FOR MEASURING RETENTATE IN FILTERS - A system and method for determining loading of a filter having a first dielectric constant with a material having a different dielectric constant, is disclosed. The filter is contained within a metallic container forming a microwave cavity, and microwave or RF energy is created within the cavity and changes in the cavity microwave response are monitored. The changes in cavity microwave response are related to filter loading. In a preferred embodiment, the microwave energy includes multiple cavity modes thereby allowing determination of spatial distribution of the contaminant material loading. In one embodiment, the microwave cavity response includes a shift in frequency of a resonant mode. Alternatively, the microwave cavity response includes a shift in quality factor Q of a resonant mode. The microwave cavity response may include a shift in amplitude or peak width of the microwave's signal at resonance. | 04-29-2010 |
20130127478 | System And Method For Measuring Retentate In Filters - A system and method for determining loading of a filter having a first dielectric constant with a material having a different dielectric constant, is disclosed. The filter is contained within a metallic container forming a microwave cavity, and microwave or RF energy is created within the cavity and changes in the cavity microwave response are monitored. The changes in cavity microwave response are related to filter loading. In a preferred embodiment, the microwave energy includes multiple cavity modes thereby allowing determination of spatial distribution of the contaminant material loading. In one embodiment, the microwave cavity response includes a shift in frequency of a resonant mode. Alternatively, the microwave cavity response includes a shift in quality factor Q of a resonant mode. The microwave cavity response may include a shift in amplitude or peak width of the microwave's signal at resonance. | 05-23-2013 |
Ronald M. Parker, Boxborough, MA US
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20090161562 | SYSTEMS AND METHODS FOR SCALABLE AND RAPID ETHERNET FAULT DETECTION - The present invention provides scalable and rapid Ethernet fault detection which eliminates the requirement to contiguously send heartbeat frames at regular intervals to detect connectivity faults for each Ethernet Path. The present invention generates Continuity Check Message (CCM) frames only when a fault occurs, continues generating CCM frames while the fault remains, and discontinues when the fault clears. The present invention can be utilized with Ethernet Protection Switching to rapidly detect faults. Additionally, the present invention can be used in any Ethernet topology including point-to-point, rings, and the like. | 06-25-2009 |
20110116460 | BURST PACKET SCHEDULER FOR IMPROVED RAN EFFICIENCY IN UMTS/HSPA NETWORKS - A method of generating optimal packet workload for achieving a balance between maximizing cell throughput and fairness across multiple users in UMTS/HSPA Network is disclosed. The packet scheduler of the current invention enhances the performance of other schedulers, such as Proportionally Fair Scheduler in NodeB and RNC in UMTS/HSPA Networks by monitoring recent RAN bandwidth to each mobile device, and increasing buffer occupancy of high rate data-flows in the RAN devices. The scheduler uses the desired performance goals of maximum cell throughput and fairness at various network congestion levels, and controls egress burst rate while delivering packets to the RAN (Radio Access Network). | 05-19-2011 |
Ronald Mark Parker, Boxborough, MA US
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20090080338 | SYSTEMS AND METHODS FOR FLOW MIRRORING WITH NETWORK-SCOPED CONNECTION-ORIENTED SINK - Systems and methods for sinking port mirrored from one or more identified flows of data to any node in a network are provided. Moreover, the network is configured to convey the mirrored data to the sink, without the need for any facilities expressly dedicated for this purpose. The present invention removes the requirement to co-locate the sink port within the same logical node. The present invention uses a mirrored flow configured as a provisioned layer two point-to-point connection, such as a Switched Permanent Virtual Circuit (SPVC), Pseudo-Wire (PWE3), a Virtual Local Area Network (VLAN) cross-connect, Provider Backbone Bridging—Traffic Engineering (PBB-TE), and the like. The node with the mirrored port is configured to create copies of the appropriate set of packets (i.e., ingress, egress packets, or both based on provisioning and based on the identified flow), and to forward the packets to the sink port through the provisioned point-to-point connection. | 03-26-2009 |
20090080425 | SYSTEMS AND METHODS FOR PORT MIRRORING WITH NETWORK-SCOPED CONNECTION-ORIENTED SINK - Systems and methods for sinking port mirrored data to any node in a network are provided. Moreover, the network is configured to convey the mirrored data to the sink, without the need for any facilities expressly dedicated for this purpose. The present invention removes the requirement to collocate the sink port within the same logical node. The present invention uses a mirrored flow configured as a provisioned layer two point-to-point connection, such as a Switched Permanent Virtual Circuit (SPVC), Pseudo-Wire (PWE3), a Virtual Local Area Network (VLAN) cross-connect, Provider Backbone Bridging-Traffic Engineering (PBB-TE), or the like. The provisioned point-to-point connection is configured between the mirrored port to a sink port. The node with the mirrored port is configured to create copies of the appropriate set of packets (i.e. ingress or egress packets or both based on provisioning), and to forward the packets to the sink port. | 03-26-2009 |
Todd M. Parker, Somerville, MA US
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20150262174 | OFFLINE ACCESS OF A NETWORK BASED APPLICATION - The present disclosure relates to an interactive computing system configured to provide a network-based application that can provide offline functionality. A user computing device, such as a mobile device, access a network-based application through an interactive computing system. The network-based application can be configured to provide transaction information sufficient to conduct a transaction with a point-of-sale terminal when the network application is not in communication with the interactive computing system. | 09-17-2015 |
20150264034 | MULTI-LAYER AUTHENTICATION - The present disclosure relates to an interactive computing system utilizing a multi-layer authentication system having a primary authentication layer and a supplemental authentication layer. The interactive computing system can be a website, web application, a mobile application or other network-based system that provides content or services to a user. Illustratively, an interactive computing system could be a marketplace for purchasing products, a content service for accessing to streaming video content, a system for accessing network-based services of a retail location, such as food service provider, or other type of interactive service. | 09-17-2015 |