Gian Maria
Gian Maria Bonora, Padova IT
Patent application number | Description | Published |
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20080280998 | Bifunctional Derivatives of Polyethylene Glycol, Their Preparation and Use - The patent describes homo- or hetero-bifunctional derivatives of polyethylene glycol (PEG) obtained by selectively modifying the hydroxyl end groups of commercial PEGs of different molecular weights with reactive bifunctional molecules. The synthesis process comprises steps involving sequential derivatization of PEG terminal hydroxyl groups with a bifunctional compound, purification of the bifunctional PEG obtained and/or protection of its functional groups with possible selective removal of terminal protections. The bifunctional PEGs (biPEG) obtained are usable as carriers and/or stabilizers for substances used for diagnostic, prophylactic and therapeutic purposes, conjugated to the same biocompatible biPEG support. The bifunctionalized PEG derivatives can also be used in supported synthesis processes. | 11-13-2008 |
Gian Maria Fimia, Grottaferrata IT
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20110281804 | PEPTIDIC AND PEPTIDOMIMETIC COMPOUNDS FOR REGULATING AUTOPHAGY - The present invention relates to peptides, peptidomimetic compounds and pharmaceutical uses thereof for the treatment of neurodegenerative diseases or tumourigenesis and more specifically diseases deriving from the dysregulation of the signalling system of Ambra-1-mediated autophagy. | 11-17-2011 |
Gian Maria Rossolini, Roma IT
Patent application number | Description | Published |
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20100216190 | Novel Selection System - The present invention relates to a method of producing a recombinant protein comprising using a selection method other than antibiotics. In particular, it relates to a stable host/vector system based on the pyrC gene complementation designed to produce high level of heterologous recombinant protein in | 08-26-2010 |