Patent application number | Description | Published |
20100160309 | INHIBITORS OF JANUS KINASES AND/OR 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE-1 - The instant invention provides for compounds that inhibit JAK2 tyrosine kinase and/or PDK1. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting JAK2 tyrosine kinase activity and/or PDK1 kinase inhibitory activity by administering the compound to a patient in need of treatment or prevention of myeloproliferative disorders or cancer. | 06-24-2010 |
20120220624 | PYRAZOLO [3,4-B] PYRIDIN-4-ONE KINASE INHIBITORS - The present invention is directed to novel kinase inhibitors of general formula (I) and pharmaceutically acceptable salts thereof, and to the use of the kinase inhibitors of general formula (I) for treating diseases or disorders in which tau phosphorylation and cell cycle regulation is implicated, such as Alzheimer's Disease and cancer. | 08-30-2012 |
20140243309 | CYCLOALKYLNITRILE PYRAZOLE CARBOXAMIDES AS JANUS KINASE INHIBITORS - The instant invention provides compounds of formula I which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer. | 08-28-2014 |
20140303142 | AZAINDOLES AS JANUS KINASE INHIBITORS - The instant invention provides compounds of formula I which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer. | 10-09-2014 |
20140349998 | PYRROLOPYRIMIDINES AS JANUS KINASE INHIITORS - The instant invention provides compounds of formula I which are JAK3 inhibitors. Specifically, the compounds of formula I are pyrrolo[2,3-d]pyrimidine derivative compounds. The instant invention also provides methods of treating JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer, by administering the pyrrolo[2,3-d]pyrimidine-derivative compounds of formula I. | 11-27-2014 |
20150329548 | SUBSTITUTED PYRROLOPYRIMIDINES AS HDM2 INHIBITORS - The present invention provides substituted pyrrolopyrimidines as described herein or a pharmaceutically acceptable salt or solvate thereof. The representative compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and potential methods of treating cancer using the same. | 11-19-2015 |
20150353553 | 2,6,7,8 SUBSTITUTED PURINES AS HDM2 INHIBITORS - The present invention provides 2,6,7,8 Substituted Purines as described herein or a pharmaceutically acceptable salt thereof. The representative compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and potential methods of treating cancer using the same. | 12-10-2015 |
Patent application number | Description | Published |
20140188723 | METHODS AND SYSTEMS FOR MITIGATING FRAUD LOSSES DURING A PAYMENT CARD TRANSACTION - Computer systems and methods for identifying a potentially fraudulent payment card transaction in progress, and mitigating losses arising from completion of a fraudulent payment card transaction are provided. The computer system is programmed to receive an authorization request message for authorization of a payment card-initiated transaction, when the transaction is initiated using a payment card that includes a first security device operable for transactions initiated within a predefined geographic region and a second security device operable for transactions initiated both within the predefined geographic region and outside of the predefined geographic region. When the transaction is initiated outside the predefined geographic region, the computer system compares data on the payment card to stored data corresponding to a plurality of payment cards previously-approved for transactions outside of the predefined geographic region approval, and applies one or more sets of rules to the transaction as appropriate. | 07-03-2014 |
20150019426 | METHOD AND SYSTEM FOR APPLYING SPENDING LIMITS TO PAYMENT ACCOUNTS INVOLVING INSTALLMENT TRANSACTIONS - A method for identifying a spending budget for a payment account includes: storing, in an account database, a plurality of account data entries, each account data entry including at least an account identifier and a base monthly spending limit; storing, in an installment database, a plurality of installment data entries, each installment data entry including at least an account identifier and an installment amount; identifying, for a specific account data entry in the account database, at least one installment data entry where the included account identifier corresponds to the account identifier of the specific account data entry; calculating an effective monthly spending limit based on the base monthly spending limit and the installment amount included in each of the identified at least one installment data entry; and associating, in the account database, the calculated effective monthly spending limit with the specific account data entry. | 01-15-2015 |
Patent application number | Description | Published |
20080206863 | Embryonic stem cells capable of differentiating into desired cells lines - An embryonic stem cell which may be induced to differentiate homogeneously into a desired primary cell line. The embryonic stem cell may be engineered with DNA, which encodes a protein or polypeptide which promotes differentiation of the stem cell into a specific cell line, such as, for example, a neuronal cell line, a muscle cell line, or a hematopoietic cell line. The DNA may encode a transcription factor found in the particular cell line. In another alternative, a desired cell line is produced from embryonic stem cells by culturing embryonic stem cells under conditions which provide for a three-dimensional network of embryonic stem cells, and then stimulating embryonic stem cells with an agent, such as retinoic acid, or dimethylsulfoxide, which promotes differentiation of the embryonic stem cells into the desired cell line, such as, for example, a neuronal cell line, or a muscle cell line. | 08-28-2008 |
20090253201 | Embryonic stem cells capable of differentiating into desired cell lines - An embryonic stem cell which may be induced to differentiate homogeneously into a desired primary cell line. The embryonic stem cell may be engineered with DNA, which encodes a protein or polypeptide which promotes differentiation of the stem cell into a specific cell line, such as, for example, a neuronal cell line, a muscle cell line, or a hematopoietic cell line. The DNA may encode a transcription factor found in the particular cell line. In another alternative, a desired cell line is produced from embryonic stem cells by culturing embryonic stem cells under conditions which provide for a three-dimensional network of embryonic stem cells, and then stimulating embryonic stem cells with an agent, such as retinoic acid, or dimethylsulfoxide, which promotes differentiation of the embryonic stem cells into the desired cell line, such as, for example, a neuronal cell line, or a muscle cell line. | 10-08-2009 |
20130041348 | Catheter-Based Delivery of Skeletal Myoblasts to the Myocardium of Damaged Hearts - The present invention provides improved systems and methods for the minimally invasive treatment of heart tissue deficiency, damage and/or loss, especially in patients suffering from disorders characterized by insufficient cardiac function, such as congestive heart failure or myocardial infarction. In certain embodiments, a cell composition comprising autologous skeletal myoblasts and, optionally, fibroblasts, cardiomyocytes and/or stem cells, is delivered to a subject's myocardium at or near the site of tissue deficiency, damage or loss, using an intravascular catheter with a deployable needle. Preferably, the cell transplantation is performed after identifying a region of the subject's myocardium in need of treatment. The inventive procedure, which can be repeated several times over time, results in improved structural and/or functional properties of the region treated, as well as in improved overall cardiac function. In particular, the inventive therapeutic methods may be performed on patients that have previously undergone CABG or LVAD implantation. | 02-14-2013 |
Patent application number | Description | Published |
20120079808 | HYDRAULIC SYSTEM FOR FAN PITCH CHANGE ACTUATION OF COUNTER-ROTATING PROPELLERS - Spaced apart counter-rotatable forward and aft rows of forward and aft propellers are mounted on forward and aft rotatable frames. Hydraulic rotary forward and aft pitch change actuators on the frames are operable for controlling pitch of the propellers. A hydraulic fluid supply outboard of the frames is connected to forward and aft rotary unions which are operable for transferring hydraulic fluid between forward and aft union stators to forward and aft union rotors mounted within the forward and aft rotary unions. The forward union rotor is operable to transfer the hydraulic fluid from the forward rotary union to the aft pitch change actuators and the aft union rotor is operable to transfer the hydraulic fluid from the aft rotary unions to the forward pitch change actuators. The forward and aft rotatable frames counter-rotatably mounted on a structural frame located forward or aft of the propellers. | 04-05-2012 |
20120079809 | PITCH CHANGE APPARATUS FOR COUNTER-ROTATING PROPELLERS - Axially spaced apart counter-rotatable forward and aft rows of forward and aft propellers mounted on forward and aft rotatable frames includes a flowpath passing through the forward and aft rotatable frames. Hydraulic rotary forward and aft pitch change actuators mounted on the aft rotatable frames are connected to and operable for controlling and setting pitch of the aft propellers. The pitch change actuators are mounted radially inwardly of the flowpath in a one to one ratio with forward and aft rotatable struts extending radially across the flowpath. One or more rotatable shafts extend through one or more of the rotatable struts and connect one or more of the pitch change actuators to one or more of the propellers. The pitch change actuators may be ganged together by unison rings having ring teeth engaging gear teeth on gears connected to the pitch change actuators or connected to the rotatable shafts. | 04-05-2012 |
20120216545 | ENVIRONMENTAL CONTROL SYSTEM SUPPLY PRECOOLER BYPASS - A precooler for cooling compressor bleed air for an environmental control system includes a heat exchanger in fluid communication with a source of cooling air and operable for cooling the bleed air. A variable bypass valve between a bleed air source and environmental control system is operable for bypassing at least a portion of the compressor bleed air around the heat exchanger. The cooling air may be a portion of fan air modulated by a variable fan air valve. The bleed air source may be selectable between the low pressure bleed air source and a high pressure bleed air source. One method includes flowing the compressor bleed air from a single low pressure source only and increasing thrust sufficiently to meet a minimum level of pressure of the bleed air during one engine out aircraft operating condition during approach or loitering. | 08-30-2012 |
20120237379 | ROTARY HYDRAULIC ACTUATOR WITH HYDRAULICALLY CONTROLLED POSITION LIMITS - A rotary hydraulic actuator includes a housing defining a chamber, a first boss, and a port block with a bore communicating with the chamber. The port block includes rotor supply and drain ports communicating with the bore, and a stator port communicating with the chamber through a stator hole in the boss. A rotor mounted in the internal chamber includes: a body with a laterally-extending arm; a first stub shaft received in the bore, the first stub shaft including base slots passing laterally therethrough; a first rotor port disposed in the arm in communication with the internal chamber, and oriented in a tangential direction relative to an axis of rotation; and internal passages which interconnect the rotor base slots and the first rotor port. Passages in the port block communicate with the bore and interconnect the rotor supply and drain ports at a first angular position of the rotor. | 09-20-2012 |
20130186059 | DUAL FUEL AIRCRAFT SYSTEM AND METHOD FOR OPERATING SAME - A dual fuel propulsion system comprising a gas turbine engine configured to generate a propulsive thrust using a cryogenic liquid fuel. | 07-25-2013 |
20150354502 | ENGINE ARCHITECTURE WITH REVERSE ROTATION INTEGRAL DRIVE AND VANELESS TURBINE - A gas turbine engine comprises a fan, a compressor, a turbine having first stage blades and second stage blades, the first stage blades rotates in a first direction and the second stage blades rotates in a second direction opposite the first direction. The first stage blades are directly adjacent to one another, a drive in operable input connection with the fan and in operable output connection with the first stage blades and the second stage blades, the first stage blades and the second stage blades driving the fan through the drive. | 12-10-2015 |
Patent application number | Description | Published |
20140020629 | TWO PIECE SHUTTER DISK ASSEMBLY FOR A SUBSTRATE PROCESS CHAMBER - Shutter disk assemblies for use in process chambers to protect a substrate support disposed below the shutter disk assembly from undesired material deposition are provided herein. In some embodiments, a shutter disk assembly for use in a process chamber to protect a substrate support disposed below the shutter disk assembly may include an upper disk member having a top surface and a bottom surface; and a lower carrier member having at least a portion of the lower carrier member disposed below a portion of the upper disk member to support the upper disk member and to create a protective overlap region that prevents exposure of the substrate support upon deformation of the upper disk member. | 01-23-2014 |
20140196746 | IN SITU CHAMBER CLEAN WITH INERT HYDROGEN HELIUM MIXTURE DURING WAFER PROCESS - Embodiments of the present invention generally relate to a method for cleaning a processing chamber during substrate processing. During a first substrate processing step, a plasma is formed from a gas mixture of argon, helium, and hydrogen in the processing chamber. In a second substrate processing step, an argon plasma is formed in the processing chamber. | 07-17-2014 |
20140196848 | FINNED SHUTTER DISK FOR A SUBSTRATE PROCESS CHAMBER - Shutter disks for use in process chambers are provided herein. In some embodiments, a shutter disk for use in a process chamber may include a body having an outer perimeter, a top surface of the body, wherein the top surface includes a central portion having a substantially horizontal planar surface, and at least one angled structure disposed radially outward of the central portion, each of the at least one angled structure having a top portion and an angled surface disposed at a downward angle in a radially outward direction from the top portion toward the outer perimeter, and a bottom surface of the body. | 07-17-2014 |