Patent application number | Description | Published |
20090004163 | METHOD OF ENHANCING PROLIFERATION AND/OR HEMATOPOIETIC DIFFERENTIATION OF STEM CELLS - The present invention provides a method for enhancing the proliferation and/or hematopoietic differentiation and/or maintenance of mammalian stem cells. The method is useful for generating expanded populations of hematopoietic stem cells (HSCs) and thus mature blood cell lineages. This is desirable where a mammal has suffered a decrease in hematopoietic or mature blood cells as a consequence of disease, radiation or chemotherapy. The method of the present invention comprises increasing the intracellular level of a cdx in stem cells, including hematopoietic stem cells, in culture, either by providing an exogenous cdx protein to the cell, or by introduction into the cell of a genetic construct encoding a cdx. The cdx is selected from the cdx family and includes cdx1, cdx2, or cdx4. The cdx may be a wild type protein appropriate for the species from which the cells are derived, or a mutant form of the protein. | 01-01-2009 |
20100278792 | METHOD OF ENHANCING PROLIFERATION AND/OR HEMATOPOIETIC DIFFERENTIATION OF STEM CELLS - The present invention provides a method for enhancing the proliferation and/or hematopoietic differentiation and/or maintenance of mammalian stem cells. The method is useful for generating expanded populations of hematopoietic stem cells (HSCs) and thus mature blood cell lineages. This is desirable where a mammal has suffered a decrease in hematopoietic or mature blood cells as a consequence of disease, radiation or chemotherapy. The method of the present invention comprises increasing the intracellular level of a cdx in stem cells, including hematopoietic stem cells, in culture, either by providing an exogenous cdx protein to the cell, or by introduction into the cell of a genetic construct encoding a cdx. The cdx is selected from the cdx family and includes cdx1, cdx2, or cdx4. The cdx may be a wild type protein appropriate for the species from which the cells are derived, or a mutant form of the protein. | 11-04-2010 |
Patent application number | Description | Published |
20090303001 | SYSTEM FOR DETECTING AND COMMUNICATING WITH RFID MEMORY DEVICES - This invention relates to a system of communicating with a radio frequency identification (RFID) transponder microchip (IC) for the purpose of accessing pre-programmed data. Such system involves direct electrical contact between the system reading the data from the memory in the transponder IC and the IC itself via two mechanical contact points. This system provides an interface with a transponder IC in order to energize the IC. Once the presence of the transponder IC is detected, the host system can read or write to and process preprogrammed data stored in the IC. | 12-10-2009 |
20100022864 | SKIN PREPARATION DEVICE AND BIOPOTENTIAL SENSOR - The skin preparation device and sensor of the present invention include an array of rigid tines. The tines serve to “self-prepare” the skin at each electrode site. These tines, when pressed against the skin, penetrate the stratum corneum, thereby reducing skin impedance and improving signal quality. A self-prepping device of the present invention is an optimized array of short non-conductive rigid tines in which the individual tines are created in a geometry that allows for a sharp point at the tip when molding, machining or etching is used as a method of fabrication. This non-conductive array with rigid penetrating structures may, therefore, be used in combination with a conductive medium, preferably an ionic conductive gel. In penetrating the stratum corneum, micro-conduits are created in the layers of the skin enabling the conductive medium to reach the low impedance layers and to transmit bioelectrical signals from the skin to the electrode surface. Such a self-prepping device can be readily mass produced using molding methods or possibly other manufacturing methods, thereby providing for a low cost means of achieving improved performance of the biopotential sensor. Additionally this invention includes the integration of this self-prepping device into a biopotential sensor comprising an array of one or more electrodes. | 01-28-2010 |
20110273270 | PHYSIOLOGICAL SENSOR SYSTEM WITH AUTOMATIC AUTHENTICATION AND VALIDATION BY MEANS OF A RADIO FREQUENCY IDENTIFICATION PROTOCOL WITH AN INTEGRATED RFID INTERROGATOR SYSTEM - This invention relates to a physiological sensor which acquires pre-programmed data from an electrode or an electrode array using Radio Frequency Identification (RFID) technology. The source of the sensor may be authenticated by means of a wireless interface between an RFID transponder affixed to the electrode array, and an RFID interrogator embedded in the patient interface cable. The criteria for use are then verified to ensure that they are met by the electrode array before beginning signal acquisition. If the criteria are not met, a message is provided to the user via the monitor. | 11-10-2011 |
20120098646 | PHYSIOLOGICAL SENSOR SYSTEM WITH AUTOMATIC AUTHENTICATION AND VALIDATION BY MEANS OF A RADIO FREQUENCY IDENTIFICATION PROTOCOL WITH AN INTEGRATED RFID INTERROGATOR SYSTEM - This invention relates to a physiological sensor which acquires pre-programmed data from an electrode or an electrode array using Radio Frequency Identification (RFID) technology. The source of the sensor may be authenticated by means of a wireless interface between an RFID transponder affixed to the electrode array, and an RFID interrogator embedded in the patient interface cable. The criteria for use are then verified to ensure that they are met by the electrode array before beginning signal acquisition. If the criteria are not met, a message is provided to the user via the monitor. | 04-26-2012 |
20120251790 | SYSTEMS AND METHODS FOR CREATING SHARP FEATURES WITHIN A MOLD - The present disclosure describes systems and methods for creating sharp features within a mold. For example, three or more mold plates may be provided to create a single mold assembly. Each mold plate includes one or more mold cavities, each having one or more surfaces. The provided mold plates may be assembled to form the mold assembly having a combined mold cavity between adjacent mold cavities of the mold plates. Although none of the individual mold cavities of the mold plates include sharp features, when the mold assembly is assembled, a combined mold cavity will include sharp transitions (e.g., angles of less than 180 degrees, right angles, angles of less than 90 degrees, and so forth) between adjacent surfaces of the mold cavities. In certain embodiments, sets of mold plates may be re-aligned to create varying mold cavity geometries. In addition, in certain embodiments, a mold pin may be inserted into an inner volume of a mold plate to both create additional sharp transitions between adjacent surfaces. | 10-04-2012 |
20130234830 | PHYSIOLOGICAL SENSOR SYSTEM WITH AUTOMATIC AUTHENTICATION AND VALIDATION BY MEANS OF A RADIO FREQUENCY IDENTIFICATION PROTOCOL WITH AN INTEGRATED RFID INTERROGATOR SYSTEM - This invention relates to a physiological sensor which acquires pre-programmed data from an electrode or an electrode array using Radio Frequency Identification (RFID) technology. The source of the sensor may be authenticated by means of a wireless interface between an RFID transponder affixed to the electrode array, and an RFID interrogator embedded in the patient interface cable. The criteria for use are then verified to ensure that they are met by the electrode array before beginning signal acquisition. If the criteria are not met, a message is provided to the user via the monitor. | 09-12-2013 |
20130253491 | Cryosurgery System - A cryosurgery system for application of medical-grade liquid nitrogen to a treatment area via a small, low pressure, open tipped catheter. The system includes a console, including a touch panel computer, a cryogen module , a suction module and an electronics module, and a disposable spray kit. Features include optional low cryogen flow setting to reduce the cryogen flow rate by 50%, improved cryogen flow consistency reducing pressure pulses and peaks, an integrated suction pump for improved consistency and self-checks, specified vent tube areas and corresponding maximum expected pressures during cryospray procedure; optional pressure sensing capability to monitor pressure during a treatment, and novel catheter designs of multilayer and flexible construction providing a variety of spray patterns. | 09-26-2013 |
20130293357 | METHOD FOR DETECTING AND COMMUNICATING WITH RFID MEMORY DEVICES - This invention relates to a system of communicating with a radio frequency identification (RFID) transponder microchip (IC) for the purpose of accessing pre-programmed data. Such system involves direct electrical contact between the system reading the data from the memory in the transponder IC and the IC itself via two mechanical contact points. This system provides an interface with a transponder IC in order to energize the IC. Once the presence of the transponder IC is detected, the host system can read or write to and process preprogrammed data stored in the IC. | 11-07-2013 |
20140024931 | Data Encoders for Medical Devices and Related Methods - In part, the invention relates to systems, methods, and devices that store and retrieve information associated with an imaging probe such as an ultrasound probe, an optical coherence tomography probe, a multimodal probe and other probes. The information that is stored relates to one or more measurable properties for a specific imaging probe. Thus, when each probe is manufactured there can be variations in its length, brightness, angular alignment of its constituent elements, and various other probe specific measurements. In turn, these measurements can be used to calibrate or otherwise use a given probe with a system that collects, stores, or otherwise processes information collected using each probe. | 01-23-2014 |
20140159917 | PHYSIOLOGICAL SENSOR SYSTEM WITH AUTOMATIC AUTHENTICATION AND VALIDATION BY MEANS OF A RADIO FREQUENCY IDENTIFICATION PROTOCOL WITH AN INTEGRATED RFID INTERROGATOR SYSTEM - This invention relates to a physiological sensor which acquires pre-programmed data from an electrode or an electrode array using Radio Frequency Identification (RFID) technology. The source of the sensor may be authenticated by means of a wireless interface between an RFID transponder affixed to the electrode array, and an RFID interrogator embedded in the patient interface cable. The criteria for use are then verified to ensure that they are met by the electrode array before beginning signal acquisition. If the criteria are not met, a message is provided to the user via the monitor. | 06-12-2014 |
20140296683 | SKIN PREPARATION DEVICE AND BIOPOTENTIAL SENSOR - The skin preparation device and sensor of the present invention include an array of rigid tines. The tines serve to “self-prepare” the skin at each electrode site. These tines, when pressed against the skin, penetrate the stratum corneum, thereby reducing skin impedance and improving signal quality. A self-prepping device of the present invention is an optimized array of short non-conductive rigid tines in which the individual tines are created in a geometry that allows for a sharp point at the tip when molding, machining or etching is used as a method of fabrication. This non-conductive array with rigid penetrating structures may, therefore, be used in combination with a conductive medium, preferably an ionic conductive gel. In penetrating the stratum corneum, micro-conduits are created in the layers of the skin enabling the conductive medium to reach the low impedance layers and to transmit bioelectrical signals from the skin to the electrode surface. Such a self-prepping device can be readily mass produced using molding methods or possibly other manufacturing methods, thereby providing for a low cost means of achieving improved performance of the biopotential sensor. Additionally this invention includes the integration of this self-prepping device into a biopotential sensor comprising an array of one or more electrodes. | 10-02-2014 |
Patent application number | Description | Published |
20080246761 | Systems for hybrid geometric/volumetric representation of 3d objects - The invention provides a system for modeling three-dimensional objects using hybrid geometric/volumetric representation, wherein sharp edges are created by a geometric representation that is connected to the volumetric representation. The system creates, maintains, and updates the hybrid representation according to user input. The system also provides for conversion of the hybrid representation into either a wholly geometric representation or a wholly volumetric representation, as may be needed for output to a given device, such as a display device, a printer, and/or a fabricating device. | 10-09-2008 |
20090248184 | Haptically enabled dental modeling system - The invention provides a digital dentistry system that utilizes a haptic interface and features a computer-based design application configured to allow the intuitive construction of irregular, amorphous three-dimensional structures typically seen in dental restorations, utilizing, where appropriate, the design skills of a user. In certain embodiments, the system provides a comprehensive digital solution for dental labs in the business of creating dental restorations such as partial frameworks, crowns, copings, bridge frameworks, implants and the like, with a sense of touch provided by a haptic interface device. | 10-01-2009 |
Patent application number | Description | Published |
20130088970 | METHODS AND APPARATUS FOR ROUTER-TO-RADIO FLOW CONTROL - Methods and apparatus for transmitting, from a radio, over a router-to-radio interface, a first transmission-on signal indicating to a router that data packets can be sent to the radio for transmission in a network, and transmitting, from the radio over the router-to-radio interface, a first transmission-off signal indicating to the router that data packet transmission should be suspended until receipt of a second transmission-on signal, wherein the first transmission-on signal and the first transmission-off signal are generated in a network layer of the seven-layer OSI model. | 04-11-2013 |
20130250955 | ROUTING A DATA PACKET IN A COMMUNICATION NETWORK - In one aspect, a method Includes receiving a data packet at a routing node that includes a processor. The method also includes determining at least one value for the data packet, selecting a routing table from a plurality of routing tables stored at the routing node in response to the at least one value for the packet and forwarding the data packet in response to the routing table selected. Each routing table is associated with a respective one cost function. | 09-26-2013 |
20140279809 | Data Broker Reasoner - A data broker-reasoner (DBR) system for automating mission planning and execution includes a context originating entity, a reasoner/decision entity, and a plurality of enforcement entities. The context originating entity extracts mission policy information from a variety of source materials, including checklists, manuals, and other documentation. The reasoner/decision entity interprets the mission policy in the context of situational awareness (SA) events to determine which policies should be enforced. Each of the enforcement entities is configured to enforce various policies within the context of a given mission lifecycle phase by providing commands, data, and requests to a plurality of user applications and/or other mission systems. The DBR can operate autonomously or semi-autonomously. | 09-18-2014 |
Patent application number | Description | Published |
20090011066 | Three-Dimensional Printer - A three-dimensional printer uses inkjet-type printheads to rapidly prototype, or print, a three-dimensional model. A powder feeder includes a conveyor system and a metering system to deliver powder to a build area in measured quantities. The powder feeder also includes a vacuum system for loading powder into a feed reservoir or chamber. The vacuum system can also be used to cleanup excess powder. Other powder control features include powder gutters and magnetic powder plows. During printing, a cleaning system operates to remove powder from the printheads. In the event of a printhead or jet failure, the failure can be detected and corrective measures taken automatically. After printing, the model can be depowdered and infiltrated in an enclosure. | 01-08-2009 |
20100151136 | Three-Dimensional Printer - A three-dimensional printer uses inkjet-type printheads to rapidly prototype, or print, a three-dimensional model. A powder feeder includes a conveyor system and a metering system to deliver powder to a build area in measured quantities. The powder feeder also includes a vacuum system for loading powder into a feed reservoir or chamber. The vacuum system can also be used to cleanup excess powder. Other powder control features include powder gutters and magnetic powder plows. During printing, a cleaning system operates to remove powder from the printheads. In the event of a printhead or jet failure, the failure can be detected and corrective measures taken automatically. After printing, the model can be depowdered and infiltrated in an enclosure. | 06-17-2010 |
20110211016 | APPARATUS AND METHODS FOR HANDLING MATERIALS IN A 3-D PRINTER - The present invention is directed towards methods and apparatus for handling powder in a 3D printer. The invention includes a means of transporting powder from multiple sources to a powder dispensing apparatus with minimal user intervention, thus reducing contamination of the 3D printer and surrounding area with loose powder, while also providing a means of improving the recycling of powder for re-use. | 09-01-2011 |
20110233808 | APPARATUS AND METHODS FOR HANDLING MATERIALS IN A 3-D PRINTER - The present invention is directed towards methods and apparatus for handling powder in a 3D printer. The invention includes a means of transporting powder from multiple sources to a powder dispensing apparatus with minimal user intervention, thus reducing contamination of the 3D printer and surrounding area with loose powder, while also providing a means of improving the recycling of powder for re-use. | 09-29-2011 |