Patent application number | Description | Published |
20150030601 | E1 ENZYME MUTANTS AND USES THEREOF - The invention provides isolated nucleic acids molecules, designated UBA3, UAE, or UBA6, or other E1 enzyme variant nucleic acid molecules, which encode novel E1 enzyme variant proteins. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing UBA3, UAE, or UBA6, or other E1 enzyme variant nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a UBA3, UAE, or UBA6, or other E1 enzyme variant gene has been introduced or disrupted. The invention still further provides isolated UBA3, UAE, or UBA6, or other E1 enzyme variant proteins, fusion proteins, antigenic peptides and anti-UBA3, UAE, or UBA6, or other E1 enzyme variant antibodies. The invention provides methods to identify agents that inhibit UBA3, UAE, or UBA6, or other E1 enzyme variant expression or activity. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided. | 01-29-2015 |
20150210700 | INDOLE-SUBSTITUTED PYRROLOPYRIMIDINYL INHIBITORS OF UBA6 - Disclosed are chemical entities that inhibit Uba6, each of which is a compound of Formula /: Formula (I) or a pharmaceutically acceptable salt thereof, wherein R* | 07-30-2015 |
Patent application number | Description | Published |
20090172132 | METHOD AND SYSTEM FOR PROVIDING IMAGE RICH WEB PAGES FROM A COMPUTER SYSTEM OVER A NETWORK - The present invention is related to a computer system that provides a web page to a requestor over a network. Aspects of the present invention include receiving by the computer system a request to access a web page and in response, determining whether a descriptor for the requested web page is in a session memory. If the descriptor is not in the session memory, it is retrieved from a database and the stored in the session memory. From there, the descriptor is used to determine whether the web page should be retrieved and returned to the requestor. By storing the descriptor in session memory, additional accesses to the database can be avoided when the descriptor is used for subsequent tasks. | 07-02-2009 |
20090276328 | METHOD AND SYSTEM FOR SUPPORTING SECURE TRANSACTIONS IN A PEER-TO-PEER NETWORK - At least two computer systems in a peer-to-peer network are utilized to support a secure transaction. Aspects of the present invention include allowing a shopper to create an order to purchase an item stored on a first computer system in the peer-to-peer network, and after the order is created, passing the order and control from the first computer system to a second computer system in the peer-to-peer network. The second computer system establishes a secure transaction session with the shopper, and then proceeds to process the order. | 11-05-2009 |
20100169465 | SERVING CONTENT FROM AN OFF-LINE PEER SERVER IN A PHOTOSHARING PEER-TO-PEER NETWORK IN RESPONSE TO A GUEST REQUEST - A method and system for serving content from a peer server in a photosharing peer-to-peer network is disclosed, wherein the peer server stores a web album and at least one associated digital image. Aspects of the invention include prior to the peer server going off-line, the peer server initiates a synchronization with a proxy server and a guest content server in which the web page a web page descriptor defining the web album is copied from the peer server to the guest content server, and the image associated with the web album is copied from the peer server to the proxy server. In response to a request from a requesting computer to view content stored in the peer computer when the peer server is off-line, the request is fulfilled by forwarding the web page from the guest content server to the requesting computer, and forwarding the image associated with a web page from the proxy server to the requesting computer, thereby successfully serving content from the peer server even when the peer server is off-line. | 07-01-2010 |
20120066038 | DYNAMIC TALK RADIO PROGRAM SCHEDULING - Methods and systems for dynamically scheduling a talk radio program include registering potential participants of a talk radio program service and receiving participant preferences for each of the potential participants, wherein the participant preferences include at least one topic of interest and a time availability; scheduling a talk radio program for production when a combination the participant preferences reach predetermined thresholds; and sending the potential participants a notification of the scheduling of the talk radio program. | 03-15-2012 |
20130290051 | Dynamic Talk Radio Program Scheduling - Methods and systems for dynamically scheduling a talk radio program include registering potential participants of a talk radio program service and receiving participant preferences for each of the potential participants, wherein the participant preferences include at least one topic of interest and a time availability; scheduling a talk radio program for production when a combination the participant preferences reach predetermined thresholds; and sending the potential participants a notification of the scheduling of the talk radio program. | 10-31-2013 |
Patent application number | Description | Published |
20080306817 | Methods and Systems of Presenting Advertisements in Consumer-Defined Environments - Targeted or other advertising may comprise one or more advertisements presented in a virtual world environment constructed according to consumer parameters, with the advertisements presented according to rules, scripts, or other parameters defined by the advertiser(s). For instance, one or more consumer computing device(s) can access data defining a brand name, logo, and/or message and can access data defining consumer preferences for the context in which advertisements are to be presented. For example, the context may vary according to viewer identity, programming content, time of day, and the like. Then, the consumer computing device(s) can render a virtual world based on the consumer preferences with the virtual world also comprising the advertisement(s) generated based on advertiser definitions. | 12-11-2008 |
20080307066 | Systems and Methods of Providing Collaborative Consumer-Controlled Advertising Environments - Targeted or other advertising may comprise one or more advertisements presented to multiple users in a virtual world environment such that participating users can interact with one another and/or with executed advertisements. Groups of users may be invited to participate in collaborative virtual world environments based on consumer contact lists or profiles establishing matching preferences for such groups. Synchronized data may be narrowcasted or broadcasted to invited users. Such data may define one or more virtual world environments as well as traditional and/or virtual world advertisements for execution in the shared environment(s). Advertisements may be selected based on one or more consumer preferences associated with one or more of the users participating in the shared virtual world environment. | 12-11-2008 |
20090063983 | SYSTEM AND METHOD FOR REPRESENTING CONTENT, USER PRESENCE AND INTERACTION WITHIN VIRTUAL WORLD ADVERTISING ENVIRONMENTS - A control system renders a shared virtual environment to one or more users and obtains metadata associated with content accessed by the users. Representations based on the gathered metadata are provided to a viewing user, and may include visual elements serving as host, content and/or presence representations. Applicable representations are identified from a plurality of defined possible content representations based on the metadata associated with and obtained for a hosting user. The representations may be descriptive of a variety of parameters, including but not limited to the type, timing, nature or other parameters associated with content currently being accessed by a hosting user, content available from the hosting user, a future schedule for content access, time remaining for the hosting user to remain within a shared virtual environment, the hosting user's social network status relative to the viewing user. Presence representations may be displayed to provide information on a hosting user's presence availability within a shared virtual environment elative to one or more determined time slots. | 03-05-2009 |
20110113098 | SYSTEM AND METHOD FOR SOCIAL NETWORK TRUST ASSESSMENT - A first user's trust level with regard to a second user can be determined by providing questions to the second user, with the questions based on a previously-collected knowledge base including information about the first user. The information about the first user may be partitioned into levels of trust, and the second user's responses to the questions may be evaluated to determine which level of trust the second user is entitled to. The knowledge base may be assembled by prompting the first user for information and/or by scanning or otherwise collecting already-existing data about the first user. The knowledge base and/or trust assessment may be distributed across a network, and in some embodiments the knowledge base or parts thereof is distributed to other users according to the trust level of those users. | 05-12-2011 |
20120291137 | SYSTEM AND METHOD FOR SOCIAL NETWORK TRUST ASSESSMENT - A first user's trust level with regard to a second user can be determined by providing questions to the second user, with the questions based on a previously-collected knowledge base including information about the first user. The information about the first user may be partitioned into levels of trust, and the second user's responses to the questions may be evaluated to determine which level of trust the second user is entitled to. The knowledge base may be assembled by prompting the first user for information and/or by scanning or otherwise collecting already-existing data about the first user. The knowledge base and/or trust assessment may be distributed across a network, and in some embodiments the knowledge base or parts thereof is distributed to other users according to the trust level of those users. | 11-15-2012 |
Patent application number | Description | Published |
20110160127 | Prodrugs of Neuraminidase Inhibitors - A new class of neuramidase inhibitor prodrugs is provided characterized by a prodrug moiety of a carboxyl group modified to form a carbonyl ethoxy amino acid, a carbonyl ethoxy dipeptide or a carbonyl ethoxy tripeptide, a guanidine group modified to form a carbonyl ethoxy amino acid, a carbonyl ethoxy dipeptide, a carbonyl ethoxy tripeptide; a primary alcohol modified to form an esterified single amino acid, dipeptide or tripeptide of zanavimir of the unaltered therapeutic agent. Exemplary therapeutic agents so modified to form prodrugs include zanavimir, oseltamivir and peramivir. The prodrug has increased oral bioavailability relative to the unaltered neuraminidase inhibitor and is effective in the inhibition of viral infections involving neuraminidase in the viral reproductive cycle. | 06-30-2011 |
20120058937 | Prodrugs of Neuraminidase Inhibitors - A new class of neuramidase inhibitor prodrugs is provided characterized by a prodrug moiety of a carboxyl group modified to form a carbonyl ethoxy amino acid, a carbonyl ethoxy dipeptide or a carbonyl ethoxy tripeptide, a guanidine group modified to form a carbonyl ethoxy amino acid, a carbonyl ethoxy dipeptide, a carbonyl ethoxy tripeptide; a primary alcohol modified to form an esterified single amino acid, dipeptide or tripeptide of zanavimir of the unaltered therapeutic agent. Exemplary therapeutic agents so modified to form prodrugs include zanavimir, oseltamivir and peramivir. The prodrug has increased oral bioavailability relative to the unaltered neuraminidase inhibitor and is effective in the inhibition of viral infections involving neuraminidase in the viral reproductive cycle. | 03-08-2012 |
20140155350 | Prodrugs of Neuraminidase Inhibitors - A new class of neuramidase inhibitor prodrugs is provided characterized by a prodrug moiety of a carboxyl group modified to form a carbonyl ethoxy amino acid, a carbonyl ethoxy dipeptide or a carbonyl ethoxy tripeptide, a guanidine group modified to form a carbonyl ethoxy amino acid, a carbonyl ethoxy dipeptide, a carbonyl ethoxy tripeptide; a primary alcohol modified to form an esterified single amino acid, dipeptide or tripeptide of zanavimir of the unaltered therapeutic agent. Exemplary therapeutic agents so modified to form prodrugs include zanavimir, oseltamivir and peramivir. The prodrug has increased oral bioavailability relative to the unaltered neuraminidase inhibitor and is effective in the inhibition of viral infections involving neuraminidase in the viral reproductive cycle. | 06-05-2014 |
Patent application number | Description | Published |
20140099814 | COAXIAL CABLE CONNECTOR HAVING ELECTRICAL CONTINUITY MEMBER - A coaxial cable connector comprising a connector body; a post engageable with the connector body, wherein the post includes a flange; a nut, axially rotatable with respect to the post and the connector body, the nut having a first end and an opposing second end, wherein the nut includes an internal lip, and wherein a second end portion of the nut corresponds to the portion of the nut extending from the second end of the nut to the side of the lip of the nut facing the first end of the nut at a point nearest the second end of the nut, and a first end portion of the nut corresponds to the portion of the nut extending from the first end of the nut to the same point nearest the second end of the nut of the same side of the lip facing the first end of the nut; and a continuity member disposed within the second end portion of the nut and contacting the post and the nut, so that the continuity member extends electrical grounding continuity through the post and the nut is provided. | 04-10-2014 |
20140106592 | COAXIAL CABLE CONNECTOR HAVING ELECTRICAL CONTINUITY MEMBER - A coaxial cable connector comprising a connector body; a post engageable with the connector body, wherein the post includes a flange; a nut, axially rotatable with respect to the post and the connector body, the nut having a first end and an opposing second end, wherein the nut includes an internal lip, and wherein a second end portion of the nut corresponds to the portion of the nut extending from the second end of the nut to the side of the lip of the nut facing the first end of the nut at a point nearest the second end of the nut, and a first end portion of the nut corresponds to the portion of the nut extending from the first end of the nut to the same point nearest the second end of the nut of the same side of the lip facing the first end of the nut; and a continuity member disposed within the second end portion of the nut and contacting the post and the nut, so that the continuity member extends electrical grounding continuity through the post and the nut is provided. | 04-17-2014 |
20140106615 | COAXIAL CABLE CONNECTOR HAVING ELECTRICAL CONTINUITY MEMBER - A coaxial cable connector comprising a connector body; a post engageable with the connector body, wherein the post includes a flange; a nut, axially rotatable with respect to the post and the connector body, the nut having a first end and an opposing second end, wherein the nut includes an internal lip, and wherein a second end portion of the nut corresponds to the portion of the nut extending from the second end of the nut to the side of the lip of the nut facing the first end of the nut at a point nearest the second end of the nut, and a first end portion of the nut corresponds to the portion of the nut extending from the first end of the nut to the same point nearest the second end of the nut of the same side of the lip facing the first end of the nut; and a continuity member disposed within the second end portion of the nut and contacting the post and the nut, so that the continuity member extends electrical grounding continuity through the post and the nut is provided. | 04-17-2014 |
20140120757 | CONNECTOR HAVING A CONTINUITY MEMBER OPERABLE IN A RADIAL DIRECTION - A connector for a coaxial cable. The connector, in one embodiment, includes a post, a coupler and a continuity member configured to produce a radially-directed biasing force. The continuity member provides an electrical connection between the post and the coupler | 05-01-2014 |
20140220807 | COAXIAL CABLE CONNECTOR HAVING ELECTRICAL CONTINUITY MEMBER - A coaxial cable connector includes, in one embodiment, a body, a post, a coupler and a continuity member. The continuity member has a post contact portion and a coupler contact portion. The post contact portion has an anchored portion. The coupler contact portion has an arcuate portion. | 08-07-2014 |
20140322967 | COAXIAL CABLE CONNECTOR HAVING ELECTRICAL CONTINUITY MEMBER - A coaxial cable connector includes, in one embodiment, a body, post, coupler and continuity member. The continuity member has an anchored post contact portion and a plurality of arcuate coupler contact portions. The connector is configured to form an electrical grounding continuity path. | 10-30-2014 |
Patent application number | Description | Published |
20130058229 | METHOD AND APPARATUS FOR ROBUST PACKET DISTRIBUTION AMONG HIERARCHICAL MANAGED SWITCHING ELEMENTS - For a network that includes several managed edge switching elements and several managed non-edge switching elements that are for implementing a logical switching element, some embodiments provide a method of distributing packet processing across the several managed non-edge switching elements. The method receives a packet for processing through the logical switching element. Based on a determination that the packet needs to be processed by a managed non-edge switching element, the method determines a particular managed non-edge switching element of the several managed non-edge switching elements to forward the packet. The method forwards the packet to the particular managed non-edge switching element for the particular managed non-edge switching element to process the packet. | 03-07-2013 |
20130058250 | HIERARCHICAL MANAGED SWITCH ARCHITECTURE - Some embodiments provide a method for managing several managed switching elements in a network. The method determines configurations for the several managed switching elements to implement a first logical data path set. Based on the determined configurations, the method configures a first set of the several managed switching elements to implement the first logical data path set. The method configures a second set of the several managed switching elements to implement a second logical data path set. | 03-07-2013 |
20130058252 | MESH ARCHITECTURES FOR MANAGED SWITCHING ELEMENTS - Some embodiments provide a network architecture that includes several lower level managed switching elements for forwarding network data to several of network hosts. The network architecture includes a set of higher level managed switching elements. The several lower level managed switching elements and the set of higher level managed switching elements implement several logical datapath sets. Communication channels are established among the several lower level managed switching elements and the set of higher level managed switching elements based on a mesh topology. | 03-07-2013 |
20130058255 | MANAGED SWITCH ARCHITECTURES: SOFTWARE MANAGED SWITCHES, HARDWARE MANAGED SWITCHES, AND HETEROGENEOUS MANAGED SWITCHES - Some embodiments provide a system that includes a set of network controllers for receiving definitions of first and second logical switching elements. The system includes several managed switching elements. The set of network controllers configure the several managed switching elements to implement the defined first and second logical switching elements. The system includes several network hosts that are each (1) communicatively coupled to one of the several managed switching elements and (2) associated with one of the first and second logical switching elements. Network data communicated between network hosts associated with the first logical switching element are isolated from network data communicated between network hosts associated with the second logical switching element. | 03-07-2013 |
20130058334 | PACKET PROCESSING IN A NETWORK WITH HIERARCHICAL MANAGED SWITCHING ELEMENTS - Some embodiments provide a managed network for implementing a logical switching element. The managed network includes several managed edge switching elements that are each for (1) receiving packets for forwarding through the logical switching element and (2) forwarding packets that are known to the managed edge switching element to other managed edge switching elements in the several managed edge switching elements. The managed network includes a set of managed non-edge switching elements for (1) receiving packets from the several managed edge switching elements that are unknown to a particular managed edge switching element in the several managed edge switching elements and (2) forwarding packets to the several managed edge switching elements that are unknown to the several managed edge switching elements. | 03-07-2013 |
20130058335 | PACKET PROCESSING FOR LOGICAL DATAPATH SETS - Some embodiments provide a method that processes network data through a network. The method receives a packet destined for a network host associated with a logical datapath set implemented by a set of managed edge switching elements and a set of managed non-edge switching elements in the network. The method determines whether the packet is a known packet. When the packet is a known packet, the method forwards the packet to a managed switching element in the set of managed edge switching elements for forwarding to the network host. When the packet is not a known packet, the method forwards the packet to a managed switching element in the set of managed non-edge switching elements for further processing. | 03-07-2013 |
20130058354 | MANAGED SWITCHING ELEMENTS USED AS EXTENDERS - Some embodiments provide a network system that includes a first network and a second network. The first network includes several unmanaged switching elements. The second network includes several managed switching elements. The network system includes a particular managed switching element for communicating network data between the first and second networks. | 03-07-2013 |
20130060940 | NETWORK VIRTUALIZATION - Some embodiments of the invention provide a robust scaling-out of network functionality by providing a software layer, called the network hypervisor, that sits between the network forwarding functions (i.e., the forwarding plane) and the network control interfaces (i.e., the control plane). The network hypervisor of some embodiments provides a logical abstraction of the network's forwarding functionality, so that network operators make their control decisions in terms of this abstraction, independent of the details of the underlying networking hardware. The network hypervisor of some embodiments may then “compile” commands placed against this abstraction into configurations of the underlying hardware. Accordingly, in some embodiments, there are two design challenges: (1) the choice of the network abstraction, and (2) the technology needed to compile the logical “abstract” controls into low-level configurations. | 03-07-2013 |
20150085655 | ADJUSTING CONNECTION VALIDATING CONTROL SIGNALS IN RESPONSE TO CHANGES IN NETWORK TRAFFIC - Some embodiments provide a method for reducing the transmission of connection validating control signals when they are not needed. Network entities transmit connection validating control signals over network connections at regular intervals to validate that the network connections and the network entities remain functional. The method monitors data traffic fluctuations on the network connections to determine when connection validating control signals may not be needed. The method reduces unnecessary connection validating control signals in order to optimize the usage of network resources. | 03-26-2015 |
20150089048 | ADJUSTING CONNECTION VALIDATING CONTROL SIGNALS IN RESPONSE TO CHANGES IN NETWORK TRAFFIC - Some embodiments provide a method for reducing the transmission of connection validating control signals when they are not needed. Network entities transmit connection validating control signals over network connections at regular intervals to validate that the network connections and the network entities remain functional. The method monitors data traffic fluctuations on the network connections to determine when connection validating control signals may not be needed. The method reduces unnecessary connection validating control signals in order to optimize the usage of network resources. | 03-26-2015 |
20150180801 | Method and Apparatus for Implementing and Managing Virtual Switches - In general, the present invention relates to a virtual platform in which one or more distributed virtual switches can be created for use in virtual networking. According to some aspects, the distributed virtual switch according to the invention provides the ability for virtual and physical machines to more readily, securely, and efficiently communicate with each other even if they are not located on the same physical host and/or in the same subnet or VLAN. According other aspects, the distributed virtual switches of the invention can support integration with traditional IP networks and support sophisticated IP technologies including NAT functionality, stateful firewalling, and notifying the IP network of workload migration. According to further aspects, the virtual platform of the invention creates one or more distributed virtual switches which may be allocated to a tenant, application, or other entity requiring isolation and/or independent configuration state. According to still further aspects, the virtual platform of the invention manages and/or uses VLAN or tunnels (e.g, GRE) to create a distributed virtual switch for a network while working with existing switches and routers in the network. The present invention finds utility in both enterprise networks, datacenters and other facilities. | 06-25-2015 |
Patent application number | Description | Published |
20110073264 | Kraft-Pulping of Hot Water Extracted Woodchips - The method of the present invention is directed towards a method to increase the pulp yield of a lignocellulosic material, or increasing pulp bulk and/or pulp viscosity. This method comprises the following steps; preparing a lignocellulosic material, contacting the lignocellulosic material in a vessel with hot water or steam for a predetermined time, producing acetic acid from the reaction of the hot water or steam and the lignocellulosic material, lowering the pH to less than about 4, removing lignocellulosic material extracts including a large percentage of hemicellulose, acetic acid and metal ions, exposing contacted lignocellulosic material to pulping chemicals in a pulping reactor, forming a contacted lignocellulosic material pulp with a kappa number below about 19 after about 90 minutes of contact with the pulping chemicals, exposing the contacted lignocellulosic material pulp to whitening agents, and producing a whitened hot water contacted lignocellulosic material pulp. | 03-31-2011 |
20110129886 | Biorefinery Process for Extraction, Separation, and Recovery of Fermentable Saccharides, other Useful Compounds, and Yield of Improved Lignocellulosic Material from Plant Biomass - Non-food plant biomass is subjected to hot-water extraction in a pressurized vessel at an elevated temperature up to about 250° C. and at a pH below about 7.0, to yield an aqueous extract containing hemicellulosic components, other wood-derived compounds, and a lignocellulosic residue. The separated aqueous extract or liquor is purified and concentrated through a multi-step process producing fermentable sugars. At each stage, inhibitory chemicals such as acetic acid, lignin, and furfural are separated and eventually recovered as commercial chemicals. The lignocellulosic residue may be further processed, as a material with enhanced resistance to sorption of water, for manufacture of improved pulp and paper, construction materials, pellet fuel, and/or other useful products. | 06-02-2011 |
20130112359 | PRODUCT AND PROCESSES FROM AN INTEGRATED FOREST BIOREFINERY - An omnibus process of pulping and bleaching lignocellulosic materials in which a charge of a lignocellulosic material is biopulped and/or water extracted prior to pulping and bleaching. The lignocellulosic material may be mechanically pulped and bleached in the presence of an enzyme that breaks lignin-carbohydrate complexes. The aqueous extract in embodiments including a water extract step is separated into acetic acid and hemicellulose sugar aqueous solutions. | 05-09-2013 |
20140162324 | Biorefinery Process for Extraction, Separation and Recovery of Fermentable Saccharides, Other Useful Compounds, and Yield of Improved Lignocellulosic Material from Plant Biomass - Non-food plant biomass is subjected hot-water extraction in a pressurized vessel at an elevated temperature up to about 250° C. without addition of reagents, to yield an aqueous extract containing hemicellulosic components and a lignocellulosic residue. The process leaves the lignocellulose substantially intact, but with the hemicellulosic content largely removed. The separated aqueous extract or liquor is concentrated and purified, and long-chain sugars are reduced into monomer saccharides. The lignocellulosic residue may be further processed, to yield a useful fibrous material that is highly resistant to sorption of water. This material may be used for composite materials that resist water degradation, or may be used to produce a higher thermal-yield, water-resistant fuel, or may be used as bioconversion feedstock for producing high-value, lignocellulosic derivatives. | 06-12-2014 |
20140182796 | PRODUCT AND PROCESSES FROM AN INTEGRATED FOREST BIOREFINERY - An omnibus process of pulping and bleaching lignocellulosic materials in which a charge of a lignocellulosic material is biopulped and/or water extracted prior to pulping and bleaching. The lignocellulosic material may be mechanically pulped and bleached in the presence of an enzyme that breaks lignin-carbohydrate complexes. The aqueous extract in embodiments including a water extract step is separated into acetic acid and hemicellulose sugar aqueous solutions. | 07-03-2014 |
20150136344 | PRODUCT AND PROCESSES FROM AN INTEGRATED FOREST BIOREFINERY - An omnibus process of pulping and bleaching lignocellulosic materials in which a charge of a lignocellulosic material is biopulped and/or water extracted prior to pulping and bleaching. The lignocellulosic material may be mechanically pulped and bleached in the presence of an enzyme that breaks lignin-carbohydrate complexes. The aqueous extract in embodiments including a water extract step is separated into acetic acid and hemicellulose sugar aqueous solutions. | 05-21-2015 |