Patent application number | Description | Published |
20100188069 | SENSORS USING HIGH ELECTRON MOBILITY TRANSISTORS - Embodiments of the invention include sensors comprising high electron mobility transistors (HEMTs) with capture reagents on a gate region of the HEMTs. Example sensors include HEMTs with a thin gold layer on the gate region and bound antibodies; a thin gold layer on the gate region and chelating agents; a non-native gate dielectric on the gate region; and nanorods of a non-native dielectric with an immobilized enzyme on the gate region. Embodiments including antibodies or enzymes can have the antibodies or enzymes bound to the Au-gate via a binding group. Other embodiments of the invention are methods of using the sensors for detecting breast cancer, prostate cancer, kidney injury, glucose, metals or pH where a signal is generated by the HEMT when a solution is contacted with the sensor. The solution can be blood, saliva, urine, breath condensate, or any solution suspected of containing any specific analyte for the sensor. | 07-29-2010 |
20110068372 | SENSORS USING HIGH ELECTRON MOBILITY TRANSISTORS - Embodiments of the invention include sensors comprising AlGaAs/GaAs high electron mobility transistors (HEMTs), inGaP/GaAs HEMTs. InAlAs/InGaAs HEMTs, AlGaAs/InGaAs PHEMTs, InAlAs/InGaAs PHEMTs, Sb based HEMTs, or InAs based HEMTs, the HEMTs having functionalization at a gate surface with target receptors. The target receptors allow sensitivity to targets (or substrates) for detecting breast cancer, prostate cancer, kidney injury, chloride, glucose, metals or pEI where a signal is generated by the HEMI when a solution is contacted with the sensor. The solution can be blood, saliva, urine, breath condensate, or any solution suspected of containing any specific analyte for the sensor. | 03-24-2011 |
Patent application number | Description | Published |
20110192861 | MEDICAL GLOVE DISPENSING DEVICE AND ASSEMBLY AND METHOD OF DISPENSING MEDICAL GLOVES - A medical glove dispensing device includes a panel having a plurality of differently sized ports, wherein each of the ports is sized to provide indicia about a size of a medical glove adapted to be disposed behind and dispensed through the port. A holder is disposed adjacent the panel and provides a plurality of storage spaces sized and adapted to support a plurality of medical glove containers holding differently sized medical gloves. The plurality of storage spaces are aligned respectively with the plurality of ports, with each of the storage spaces having substantially the same width. A medical glove dispensing assembly, and a method of dispensing medical gloves, are also provided. | 08-11-2011 |
20110219706 | WALL MOUNTED ASSEMBLY - A wall assembly includes at least one horizontally extending rail having a rear surface adapted to engage the wall. A plurality of horizontally spaced and vertically extending stiles are coupled to the rail, with the stiles disposed forwardly of the rear surface of the rail. A plurality of interface components are coupled to the plurality of stiles. In various embodiments, the stiles may be interconnected to draw together adjacent interface components. The interface components also may include overlapping upper and lower edges. The stiles may be vertically and/or horizontally (laterally and longitudinally) adjustable relative to the rail. A lock member may be provided to secure at least one of the stiles to the rail. Various systems and methods of assembly and use are also provided. | 09-15-2011 |
20130239486 | WALL MOUNTED ASSEMBLY - A wall assembly includes at least one horizontally extending rail having a rear surface adapted to engage the wall. A plurality of horizontally spaced and vertically extending stiles are coupled to the rail, with the stiles disposed forwardly of the rear surface of the rail. A plurality of interface components are coupled to the plurality of stiles. In various embodiments, the stiles may be interconnected to draw together adjacent interface components. The interface components also may include overlapping upper and lower edges. The stiles may be vertically and/or horizontally (laterally and longitudinally) adjustable relative to the rail. A lock member may be provided to secure at least one of the stiles to the rail. Various systems and methods of assembly and use are also provided. | 09-19-2013 |
20140242928 | PORTABLE RADIO HAVING ACCESSORY INTERFACE - An improved user interface is provided by a portable radio ( | 08-28-2014 |
20140298732 | WALL MOUNTED ASSEMBLY - A wall assembly includes at least one horizontally extending rail having a rear surface adapted to engage the wall. A plurality of horizontally spaced and vertically extending stiles are coupled to the rail, with the stiles disposed forwardly of the rear surface of the rail. A plurality of interface components are coupled to the plurality of stiles. In various embodiments, the stiles may be interconnected to draw together adjacent interface components. The interface components also may include overlapping upper and lower edges. The stiles may be vertically and/or horizontally (laterally and longitudinally) adjustable relative to the rail. A lock member may be provided to secure at least one of the stiles to the rail. Various systems and methods of assembly and use are also provided. | 10-09-2014 |
Patent application number | Description | Published |
20100203564 | Fluorescent Phospholipase A2 Indicators - Compositions, methods of synthesis and applications of phospholipase A | 08-12-2010 |
20100291547 | FLUOROGENIC HYDRAZINE-SUBSTITUTED COMPOUNDS - The present disclosure is directed to fluorogenic schiff base-forming dyes capable of detecting analytes containing aldehyde and ketone groups. The dyes contain nucleophilic hydrazinyl appendages and are capable of binding and detecting analytes in situ. | 11-18-2010 |
20110045503 | The Use of Novel Coumarins as Glutathione and Thiol Labels - Fluorescent quinolizinocoumarin compounds substituted with electrophilic reactive groups that bind thiol compounds are described. The compounds are useful in detecting oxidative stress and processes associated therewith in live cells. | 02-24-2011 |
20110313129 | LARGE STOKES SHIFT DYES - Provided herein are heptamethine cyanine dyes having a large Stokes shift, and the salts and conjugates thereof. Also provided are methods of using and making such large Stokes shift dyes as fluorescence resonance energy transfer (FRET) acceptors or donors. | 12-22-2011 |
20130211119 | Hydrophobic Diacrylamide Compound - A silyl protected diacrylamide compound is described. A method of forming such a compound includes mixing a silylation reagent with a hydroxylated diamine compound under first reactive conditions to form a product in a first solution, separating the product from the first solution, and mixing the product with acryloyl chloride under second reactive conditions in a second solution to form a silyl protected diacrylamide compound. | 08-15-2013 |
20130287689 | Modified Hydrocyanine Dyes for the Detection of Reactive Oxygen Species - The present invention is directed to compounds, compositions, methods, and kits for detecting reactive oxygen species (ROS) by conventional fluorescence microscopy, fluorescence spectroscopy, flow cytometry, and/or high content imaging. The compounds disclosed herein are novel reduced dyes, including Cy-based hydrocyanine dyes and Cy-based deuterocyanine dyes, which dyes are probes for detecting ROS and measuring oxidative stress in cells either in vitro and/or in vivo. Also described herein are processes for preparing novel reduced dyes, i.e., ROS probes, for use in the disclosed compositions, methods and kits. | 10-31-2013 |
20130288911 | FLUOROGENIC HYDRAZINE-SUBSTITUTED COMPOUNDS - The present disclosure is directed to fluorogenic schiff base-forming dyes capable of detecting analytes containing aldehyde and ketone groups. The dyes contain nucleophilic hydrazinyl appendages and are capable of binding and detecting analytes in situ. | 10-31-2013 |
20140073756 | Hydrophobic Diacrylamide Compound - A silyl protected diacrylamide compound is described. A method of forming such a compound includes mixing a silylation reagent with a hydroxylated diamine compound under first reactive conditions to form a product in a first solution, separating the product from the first solution, and mixing the product with acryloyl chloride under second reactive conditions in a second solution to form a silyl protected diacrylamide compound. | 03-13-2014 |
20140080966 | Hydrophobic Diacrylamide Compound - A silyl protected diacrylamide compound is described. A method of forming such a compound includes mixing a silylation reagent with a hydroxylated diamine compound under first reactive conditions to form a product in a first solution, separating the product from the first solution, and mixing the product with acryloyl chloride under second reactive conditions in a second solution to form a silyl protected diacrylamide compound. | 03-20-2014 |
20140107323 | SDP-containing Heterobifunctional Agents - The present disclosure is directed to a reactive ester agent for conjugating a click-reactive group to a carrier molecule or solid support. The reactive ester agent has the general formula IA, wherein the variables R | 04-17-2014 |
20150079622 | Modified Nucleic Acid Binding Cyanine Dyes for the Detection of Reactive Oxygen Species - Disclosed herein are compounds, compositions, methods, and kits for detecting reactive oxygen species (ROS) by conventional fluorescence microscopy, fluorescence spectroscopy, flow cytometry, and/or high content imaging. The compounds disclosed herein are novel reduced nucleic acid binding cyanine dyes, which dyes are probes for detecting ROS and measuring oxidative stress in cells either in vitro and/or in vivo. Also described herein are processes for preparing novel reduced dyes, i.e., ROS probes, for use in the disclosed compositions, methods and kits. | 03-19-2015 |
Patent application number | Description | Published |
20110256726 | PLASMA ACTIVATED CONFORMAL FILM DEPOSITION - Methods of depositing a film on a substrate surface include surface mediated reactions in which a film is grown over one or more cycles of reactant adsorption and reaction. In one aspect, the method is characterized by the following operations: (a) exposing the substrate surface to a first reactant in vapor phase under conditions allowing the first reactant to adsorb onto the substrate surface; (b) exposing the substrate surface to a second reactant in vapor phase while the first reactant is adsorbed on the substrate surface; and (c) exposing the substrate surface to plasma to drive a reaction between the first and second reactants adsorbed on the substrate surface to form the film. | 10-20-2011 |
20120077349 | PLASMA-ACTIVATED DEPOSITION OF CONFORMAL FILMS - Embodiments related to depositing thin conformal films using plasma-activated conformal film deposition (CFD) processes are described herein. In one example, a method of processing a substrate includes, applying photoresist to the substrate, exposing the photoresist to light via a stepper, patterning the resist with a pattern and transferring the pattern to the substrate, selectively removing photoresist from the substrate, placing the substrate into a process station, and, in the process station, in a first phase, generating radicals off of the substrate and adsorbing the radicals to the substrate to form active species, in a first purge phase, purging the process station, in a second phase, supplying a reactive plasma to the surface, the reactive plasma configured to react with the active species and generate the film, and in a second purge phase, purging the process station. | 03-29-2012 |
20130309415 | SYSTEMS AND METHODS FOR MODULATING STEP COVERAGE DURING CONFORMAL FILM DEPOSITION - Systems and methods for processing a substrate include a) arranging a substrate on a pedestal in a processing chamber; b) supplying precursor to the processing chamber; c) purging the processing chamber; d) performing radio frequency (RF) plasma activation; e) purging the processing chamber; and f) prior to purging the processing chamber in at least one of (c) or (e), setting a vacuum pressure of the processing chamber to a first predetermined pressure that is less than a vacuum pressure during at least one of (b) or (d) for a first predetermined period. | 11-21-2013 |
20130319329 | PLASMA-ACTIVATED DEPOSITION OF CONFORMAL FILMS - Embodiments related to depositing thin conformal films using plasma-activated conformal film deposition (CFD) processes are described herein. In one example, a method of processing a substrate includes, applying photoresist to the substrate, exposing the photoresist to light via a stepper, patterning the resist with a pattern and transferring the pattern to the substrate, selectively removing photoresist from the substrate, placing the substrate into a process station, and, in the process station, in a first phase, generating radicals off of the substrate and adsorbing the radicals to the substrate to form active species, in a first purge phase, purging the process station, in a second phase, supplying a reactive plasma to the surface, the reactive plasma configured to react with the active species and generate the film, and in a second purge phase, purging the process station. | 12-05-2013 |
20140106574 | GAPFILL OF VARIABLE ASPECT RATIO FEATURES WITH A COMPOSITE PEALD AND PECVD METHOD - Provided herein are methods and apparatus for filling one or more gaps on a semiconductor substrate. The disclosed embodiments are especially useful for forming seam-free, void-free fill in both narrow and wide features. The methods may be performed without any intervening etching operations to achieve a single step deposition. In various implementations, a first operation is performed using a novel PEALD fill mechanism to fill narrow gaps and line wide gaps. A second operation may be performed using PECVD methods to continue filling the wide gaps. | 04-17-2014 |
20140120737 | SUB-SATURATED ATOMIC LAYER DEPOSITION AND CONFORMAL FILM DEPOSITION - Methods and apparatus for depositing continuous thin films using plasma-activated sub-saturated atomic layer deposition are provided herein. According to various embodiments, pin-hole free continuous films may be deposited at thicknesses thinner than achievable with conventional methods. The methods and apparatus also provide high degree of thickness control, with films a per-cycle thickness tunable to as low as 0.1 Å in some embodiments. Further, the methods and apparatus may be used to provide films having improved properties, such as lower wet etch rate, in some embodiments. | 05-01-2014 |
20140141542 | METHODS FOR DEPOSITING FILMS ON SENSITIVE SUBSTRATES - Methods and apparatus to form films on sensitive substrates while preventing damage to the sensitive substrate are provided herein. In certain embodiments, methods involve forming a bilayer film on a sensitive substrate that both protects the underlying substrate from damage and possesses desired electrical properties. Also provided are methods and apparatus for evaluating and optimizing the films, including methods to evaluate the amount of substrate damage resulting from a particular deposition process and methods to determine the minimum thickness of a protective layer. The methods and apparatus described herein may be used to deposit films on a variety of sensitive materials such as silicon, cobalt, germanium-antimony-tellerium, silicon-germanium, silicon nitride, silicon carbide, tungsten, titanium, tantalum, chromium, nickel, palladium, ruthenium, or silicon oxide. | 05-22-2014 |
20140209562 | PLASMA ACTIVATED CONFORMAL FILM DEPOSITION - Methods of depositing a film on a substrate surface include surface mediated reactions in which a film is grown over one or more cycles of reactant adsorption and reaction. In one aspect, the method is characterized by the following operations: (a) exposing the substrate surface to a first reactant in vapor phase under conditions allowing the first reactant to adsorb onto the substrate surface; (b) exposing the substrate surface to a second reactant in vapor phase while the first reactant is adsorbed on the substrate surface; and (c) exposing the substrate surface to plasma to drive a reaction between the first and second reactants adsorbed on the substrate surface to form the film. | 07-31-2014 |
Patent application number | Description | Published |
20080299353 | Methods and compositions for forming patterns with isolated or discrete features using block copolymer materials - Methods of directing the self assembly of block copolymers on chemically patterned surfaces to pattern discrete or isolated features needed for applications including patterning integrated circuit layouts are described. According to various embodiments, these features include lines, t-junctions, bends, spots and jogs. In certain embodiments a uniform field surrounds the discrete feature or features. In certain embodiments, a layer contains two or more distinct regions, the regions differing in one or more of type of feature, size, and/or pitch. An example is an isolated spot at one area of the substrate, and a t-junction at another area of the substrate. These features or regions of features may be separated by unpatterned or uniform fields, or may be adjacent to one another. Applications include masks for nanoscale pattern transfer as well as the fabrication of integrated circuit device structures. | 12-04-2008 |
20090196488 | DENSITY MULTIPLICATION AND IMPROVED LITHOGRAPHY BY DIRECTED BLOCK COPOLYMER ASSEMBLY - Methods to pattern substrates with dense periodic nanostructures that combine top-down lithographic tools and self-assembling block copolymer materials are provided. According to various embodiments, the methods involve chemically patterning a substrate, depositing a block copolymer film on the chemically patterned imaging layer, and allowing the block copolymer to self-assemble in the presence of the chemically patterned substrate, thereby producing a pattern in the block copolymer film that is improved over the substrate pattern in terms feature size, shape, and uniformity, as well as regular spacing between arrays of features and between the features within each array compared to the substrate pattern. In certain embodiments, the density and total number of pattern features in the block copolymer film is also increased. High density and quality nanoimprint templates and other nanopatterned structures are also provided. | 08-06-2009 |
20120164392 | METHODS AND COMPOSITIONS FOR FORMING PATTERNS WITH ISOLATED OR DISCRETE FEATURES USING BLOCK COPOLYMER MATERIALS - Methods of directing the self assembly of block copolymers on chemically patterned surfaces to pattern discrete or isolated features needed for applications including patterning integrated circuit layouts are described. According to various embodiments, these features include lines, t-junctions, bends, spots and jogs. In certain embodiments a uniform field surrounds the discrete feature or features. In certain embodiments, a layer contains two or more distinct regions, the regions differing in one or more of type of feature, size, and/or pitch. An example is an isolated spot at one area of the substrate, and a t-junction at another area of the substrate. These features or regions of features may be separated by unpatterned or uniform fields, or may be adjacent to one another. Applications include masks for nanoscale pattern transfer as well as the fabrication of integrated circuit device structures. | 06-28-2012 |
Patent application number | Description | Published |
20110106102 | Surgical Instrument and Systems with Integrated Optical Sensor - A surgical instrument has a surgical tool that has a proximal end and a distal end, and an optical sensor that has at least a portion attached to the surgical tool. The surgical tool has a portion that is suitable to provide a reference portion of the surgical tool, and the optical sensor has an end fixed relative to the reference portion of the surgical tool such that the reference portion of the surgical tool can be detected along with tissue that is proximate or in contact with the distal end of the surgical tool while in use. | 05-05-2011 |
20120172893 | OPTICAL SENSING SYSTEM FOR COCHLEAR IMPLANT SURGERY - A sensing system for implant surgery includes an insertion device for moving an implant into a narrow cavity in a patient's body. A sensor measures the distance from an end of the insertion device to anatomic surfaces at a distance from the end of the insertion device. An optical coherence tomography (OCT) system integrates the sensor and produces OCT images, which can be quantified to distance measurements. The system is particularly useful for cochlear implant surgery. | 07-05-2012 |
20120281236 | FOUR-DIMENSIONAL OPTICAL COHERENCE TOMOGRAPHY IMAGING AND GUIDANCE SYSTEM - A four-dimensional optical coherence tomography imagining and guidance system includes an optical coherence tomography system, a data processing system adapted to communicate with the optical coherence tomography system, and a display system adapted to communicate with the data processing system. The optical coherence tomography system is configured to provide data corresponding to a plurality of volume frames per second. The data processing system is configured to receive and process the data and provide three-dimensional image data to the display system such that the display system displays a rendered real-time three-dimensional image. | 11-08-2012 |
20120283516 | DARK FIELD ENDOSCOPIC MICROSCOPE - A dark field endoscopic microscope includes an illumination system, an objective lens unit arranged in an optical path of the illumination system, an optical fiber bundle optically coupled to the objective lens unit, and an observation system arranged in an optical return path from the optical fiber bundle. The illumination system provides oblique off-axial illumination while axial rays are at least attenuated. | 11-08-2012 |
20120283804 | MID-INFRARED LASER THERAPY DEVICE AND SYSTEM - A mid-infrared laser therapy tool includes a handle, a mid-infrared laser contained within the handle, and a light pipe optically coupled to the mid-infrared laser. The mid-infrared laser emits at a wavelength within a wavelength band from about 6.0 μm to about 6.5 μm. A mid-infrared laser therapy system includes a mid-infrared laser therapy tool, an optical coherence tomography system adapted to communicate with the mid-infrared laser therapy tool, and a motorized-platform control system adapted to communicate with the mid-infrared laser therapy tool and the optical coherence tomography system. The mid-infrared laser therapy tool comprises a mid-infrared laser emits at a wavelength within a wavelength band from about 6.0 μm to about 6.5 μm. | 11-08-2012 |
20130033887 | HIGH-EFFICIENCY ILLUMINATION SYSTEM - An illumination system includes a light source, an optical waveguide that has a proximal end and a distal end such that the proximal end is arranged to receive light from the light source and the distal end is suitable to illuminate an object of interest; and an optical coupler constructed and arranged to couple light from the light source into the optical waveguide. The optical coupler includes a reflective surface that reflects at least some light diverging from the light source to be coupled into the optical waveguide. | 02-07-2013 |
20130044330 | OPTICAL COHERENCE TOMOGRAPHY SYSTEM HAVING REAL-TIME ARTIFACT AND SATURATION CORRECTION - An optical coherence tomography system having real-time artifact and saturation correction includes an optical coherence tomography unit, and a signal processing and display system adapted to communicate with the optical coherence tomography unit to receive imaging signals therefrom. The optical coherence tomography system is a Fourier Domain optical coherence tomography system. The signal processing and display system includes a parallel processor configured to correct the imaging signals, in real time, to at least partially remove image artifacts and saturation based on a subset of image data within an image frame. | 02-21-2013 |
20130188196 | LATERAL DISTORTION CORRECTED OPTICAL COHERENCE TOMOGRAPHY SYSTEM - A lateral-distortion corrected optical coherence tomography system. The system can include an optical coherence tomography sensor, a light source, a fiber-optic system arranged to provide a reference beam and an observation beam, an optical detection system arranged to receive combined light from the reference beam and the observation beam and to provide detection signals, and a data processing system arranged to communicate with the optical detection system and receive the detection signals. The data processing system can be configured to assemble an image corresponding to a scanning path by constructing a plurality of A-scans from the detection signals, determining displacement information from the plurality of A-scans, and arranging the plurality of A-scans according to the displacement information. | 07-25-2013 |
20130190734 | INTERFEROMETRIC FORCE SENSOR FOR SURGICAL INSTRUMENTS - A surgical tool system according to an embodiment of the current invention includes a surgical tool, and an interferometry system optically coupled to the surgical tool. The surgical tool includes a body section, a sensor section at least one of attached to or integral with the body section, and a surgical section at least one of attached to or integral with the sensor section at an opposing end of the sensor section from the body section. The sensor section comprises an interferometric optical sensor defining a reference distance that changes in response to at least one of a force or a torque when applied to the surgical section of the surgical tool. | 07-25-2013 |
20140063225 | MOTION-COMPENSATED CONFOCAL MICROSCOPE - A motion-compensated confocal microscope includes a laser scanning system, a fiber-optic component having a proximal end and a distal end such that the fiber-optic component is optically coupled to the laser scanning system to receive illumination light at the proximal end and to emit at least a portion of the illumination light at the distal end, and a detection system configured to receive and detect light returned from a specimen being observed and to output an image signal. The light returned from the specimen is received by the distal end of the fiber-optic component and transmitted back and out the proximal end of the fiber-optic component. The motion-compensated confocal microscope also includes a motion compensation system connected to at least one of the distal end of the fiber-optic component or to the specimen to move at least one of the distal end of the fiber-optic component or the specimen to compensate for relative motion between the distal end of the fiber-optic component and a portion of the specimen being observed. | 03-06-2014 |
20140063506 | REAL-TIME, DISPERSION-COMPENSATED LOW-COHERENCE INTERFEROMETRY SYSTEM - A real-time, dispersion-compensated low coherence interferometric system includes a fiber-optic, a bulk-optic, or a combination of bulk and fiber-optic system comprising a reference path and an observation path; a light source optically coupled to the fiber-optic, bulk-optic, or combination of bulk and fiber-optic system to illuminate the reference and observation paths; an optical detection system arranged to receive combined light returned along the reference and observation paths, the optical detection system providing detection signals; and a data processing system arranged to communicate with the optical detection system to receive the detection signals. The data processing system includes a parallel processor configured to process the detection signals to provide real-time dispersion compensation to numerically compensate for dispersion in the reference path relative to the observation path. | 03-06-2014 |
20140078512 | MOTION-COMPENSATED OPTICAL COHERENCE TOMOGRAPHY SYSTEM - A motion-compensated optical coherence tomography system includes an optical coherence tomography sensor that includes a common-path optical fiber having an end for emitting light, reflecting reference light and receiving returned light for detection; a motion-compensation system attached to the common-path optical fiber and operable to move at least a portion of the optical fiber so as to compensate for motion between the end of the common-path optical fiber and an object being imaged; and a feedback control system configured to communicate with the optical coherence tomography sensor and the motion-compensation system. The feedback control system is configured to receive information concerning a measured distance of the end of the common-path optical fiber from the object and provide instructions to the motion-compensation system to decrease an amount of deviation of the measured distance from a desired distance. | 03-20-2014 |
20140160462 | SYSTEM AND METHOD FOR ASSESSING THE FLOW OF A FLUID - A system for assessing the flow of a fluid. The system can include a light source, a fiber-optic system optically coupled to the light source, which is arranged to provide a reference beam and an observation beam, an optical detection system arranged to receive combined light from the reference beam and the observation beam and to provide detection signals, and a data processing system arranged to communicate with the optical detection system to receive the detection signals. The data processing system can be configured to use the detection signals to determine a speckle pattern corresponding to the fluid flow, wherein the speckle pattern includes a plurality of lines, and to calculate a correlation between adjacent lines perpendicular to the flow to determine at least one of a rate of the flow and a displacement of the flow. | 06-12-2014 |
20140160484 | DISTORTION CORRECTED OPTICAL COHERENCE TOMOGRAPHY SYSTEM - An axial motion distortion-corrected optical coherence tomography system. The system can include an optical coherence tomography sensor, a light source, a fiber-optic system arranged to provide a reference beam and an observation beam, an optical detection system arranged to receive combined light from the reference beam and the observation beam and to provide detection signals, and a data processing system arranged to receive said detection signals, construct a plurality of A-scans from said detection signals, and construct one or more images from said plurality of A-scans. The data processing system can be configured to correct distortion in the images caused by net axial motion of at least one of said optical coherence tomography sensor or a target of said optical coherence tomography sensor by calculating an estimate of the net axial motion using Doppler shift, and then shifting the A-scans according to the estimate. | 06-12-2014 |
20140160485 | DURABLE SINGLE MODE FIBER PROBE WITH OPTIMIZED REFERENCE REFLECTIVITY - A probe for a common path optical coherence tomography system includes a sheath having a proximal end and a distal end and defining a lumen therein, a single mode optical fiber disposed within the lumen of the sheath such that a portion of the single mode optical fiber extends beyond the distal end of the sheath. The single mode optical fiber has an end face for transmitting and receiving light. The probe also includes a layer of hardened epoxy encasing the portion of the single mode optical fiber that extends beyond the distal end of the sheath except for the end face. The single mode optical fiber has an optical axis extending along a longitudinal direction of the single mode optical fiber. The hardened epoxy is polished at a non-orthogonal angle relative to the optical axis at the end face. | 06-12-2014 |
20140160486 | SAPPHIRE LENS-BASED OPTICAL FIBER PROBE FOR OPTICAL COHERENCE TOMOGRAPHY - A probe for an optical coherence tomography system according to an embodiment of the current invention includes a sheath having a proximal end and a distal end and defining a lumen therein, an optical fiber disposed at least partially within the lumen of said sheath, and a sapphire lens attached to the distal end of the sheath to form a fluid-tight seal to prevent fluid from entering the lumen of said sheath. The optical fiber has an end arranged in an optical path with the sapphire lens to provide optical coupling between the sapphire lens and the optical fiber. | 06-12-2014 |
20140160487 | REAL-TIME 3D AND 4D FOURIER DOMAIN DOPPLER OPTICAL COHERENCE TOMOGRAPHY SYSTEM - An optical coherence tomography imaging system includes a Fourier domain optical coherence tomography sensor system, a signal processing system configured to communicate with the Fourier domain optical coherence tomography sensor system to receive detection signals therefrom and to provide imaging signals, and an image display system configured to communicate with the signal processing system to receive the imaging signals. The signal processing system includes a parallel processor configured to calculate structure information and Doppler information from the detection signals in real time such that the imaging signals provide a real time display of combined structure and flow of an object under observation. | 06-12-2014 |
20150031990 | PHOTOACOUSTIC TRACKING AND REGISTRATION IN INTERVENTIONAL ULTRASOUND - An intraoperative registration and tracking system includes an optical source configured to illuminate tissue intraoperatively with electromagnetic radiation at a substantially localized spot so as to provide a photoacoustic source at the substantially localize spot, an optical imaging system configured to form an optical image of at least a portion of the tissue and to detect and determine a position of the substantially localized spot in the optical image, an ultrasound imaging system configured to form an ultrasound image of at least a portion of the tissue and to detect and determine a position of the substantially localized spot in the ultrasound image, and a registration system configured to determine a coordinate transformation that registers the optical image with the ultrasound image based at least partially on a correspondence of the spot in the optical image with the spot in the ultrasound image. | 01-29-2015 |
Patent application number | Description | Published |
20120130258 | PROGRAMMABLE MULTIPSPECTRAL ILLIUMINATION SYSTEM FOR SURGERY AND VISUALIZATION OF LIGHT-SENSITIVE TISSUES - An observation system for viewing light-sensitive tissue includes an illumination system configured to illuminate the light-sensitive tissue, an imaging system configured to image at least a portion of the light-sensitive tissue upon being illuminated by the illumination system, and an image display system in communication with the imaging system to display an image of the portion of the light-sensitive tissue. The illumination system is configured to illuminate the light-sensitive tissue with a reduced amount of light within a preselected wavelength range compared to multispectral illumination light, and the image of the portion of the light-sensitive tissue is compensated for the reduced amount of light within the preselected frequency range to approximate an image of the light-sensitive tissue under the multispectral illumination | 05-24-2012 |
20130123759 | SURFACE TRACKING AND MOTION COMPENSATING SURGICAL TOOL SYSTEM - A motion-compensating surgical tool system includes a surgical tool that includes a hand piece and a moveable component, a drive assembly connecting the moveable component to the hand piece such that the moveable component is movable in an axial direction relative to the hand piece by the drive assembly. The motion-compensating surgical tool system also includes an optical detection system that includes an optical fiber attached to the moveable component with an end at a fixed distance to a distal-most portion of the moveable component. The optical detection system is configured to output a signal for the determination of a distance of the distal-most portion of the moveable component to a target during surgery. | 05-16-2013 |
20130271757 | REAL-TIME, THREE-DIMENSIONAL OPTICAL COHERENCE TOMOGRAPNY SYSTEM - A real-time, three-dimensional optical coherence tomography system includes an optical interferometer configured to illuminate a target with light and to receive light returned from the target; an optical detection system arranged in an optical path of light from the optical interferometer after being returned from the target, the optical detection system providing output data signals; and a data processing system adapted to communicate with the optical detection system to receive the output data signals. The data processing system includes a parallel processor configured to process the output data signals to provide real-time, three-dimensional optical coherence tomography images of the target. | 10-17-2013 |
20140039261 | OPTICAL COHERENCE TOMOGRAPHY SYSTEM AND METHOD FOR REAL-TIME SURGICAL GUIDANCE - An optical coherence tomography (OCT) system for real-time surgical guidance includes an optical source, an optical fiber configured to be optically coupled to the optical source, a plurality of OCT sensor heads configured to be optically coupled to the optical fiber, an optical detector configured to be optically coupled to the optical fiber, a signal processor configured to communicate with the optical detector to receive detected signals therefrom, and a display system configured to receive OCT image signals from the signal processor and to display an OCT image of at least a portion of a surgical region of interest in real time to provide surgical guidance. The plurality of OCT sensor heads includes a bulk sensor head configured to image at least a portion of the surgical region of interest from an external imaging position and an endoscopic sensor head configured to be inserted into the surgical region of interest to image at least a portion of the surgical region of interest from an internal imaging position. The bulk sensor head and the endoscopic sensor head are at least one of separate exchangeable sensor heads or a reconfigurable sensor head. | 02-06-2014 |
Patent application number | Description | Published |
20100150984 | BIO-ARTIFICIAL PANCREAS AND A PROCEDURE FOR PREPARATION OF SAME - The present invention generally relates to implantable devices for producing insulin in diabetic animals and to methods of making same. Some embodiments include amphiphilic biomembranes for use in biological applications (e.g., as an alternative and/or supplemental insulin source). Some embodiments also include live insulin-producing cells contained within one or more amphiphilic membranes so as to prevent or diminish an immuno-response and/or rejection by the host. | 06-17-2010 |
20100267897 | THERMOPLASTIC AMPHIPHILIC CO-NETWORKS - The present invention relates generally to thermoplastic amphiphilic networks and/or co-networks. In one embodiment, the present invention relates to thermoplastic (TP) amphiphilic co-networks (APCNs) and the preparation of membranes from such APCNs. In another embodiment, the present invention relates to an amphiphilic network comprising at least one hydrophilic polymer-derived portion, at least one hydrophobic polymer-derived portion and at least one thermoplastic polymer-derived portion. In still another embodiment, the present invention relates to thermoplastic amphiphilic co-networks prepared by combining the chemistries of APCNs and polyurethanes (PUs) and to the preparation of membranes therefrom. | 10-21-2010 |
20110213084 | POLYMERS HAVING BOTH HARD AND SOFT SEGMENTS, AND PROCESS FOR MAKING SAME - The present invention generally relates to alcohol- and amine-terminated polyisobutylene (PIB) compounds, and to a process for making such compounds. In one embodiment, the present invention relates to primary alcohol- and amine-terminated polyisobutylene compounds, and to a process for making such compounds. In still another embodiment, the present invention relates to polyisobutylene compounds that can be used to synthesize polyurethanes and polyureas, to polyurethane and polyurea compounds made via the use of such polyisobutylene compounds, and to processes for making such compounds. In yet another embodiment, the present invention relates to polyisobutylene compounds containing urea or urethane segments therein, and to a method of producing such compounds. In still yet another embodiment, the present invention relates to a polymer having one or more different soft segments and one or more different hard segments. | 09-01-2011 |
20120259069 | POLYISOBUTYLENE-BASED POLYURETHANES, POLYUREAS AND/OR POLYURETHANE-POLYUREAS AND METHOD FOR MAKING SAME - The present invention generally relates to polyisobutylene-based polyurethanes, polyureas and/or polyurethane-polyureas, and to a process for making such compounds. In one embodiment, the polyisobutylene-based polyurethanes, polyureas and/or polyurethane-polyureas also include at least one flexible hydrogen bond acceptor chain extender (HACE). In another embodiment, amine telechelic and hydroxyl telechelic polyisobutylenes are utilized with at least one at least one flexible hydrogen bond acceptor chain extender (HACE) to produce polyurethane-polyureas having various desired mechanical properties in combination with various desired oxidative/hydrolytic stability. | 10-11-2012 |
20130331538 | MELT PROCESSIBLE POLYUREAS AND POLYUREA-URETHANES, METHOD FOR THE PRODUCTION THEREOF AND PRODUCTS MADE THEREFROM - A polyurea or polyurea-urethane elastomer comprises a soft polymer segment and a hard polymer segment, wherein the hard polymer segment includes polyurea groups in combination with H-bond accepting chain extenders (HACEs) to reduce the flow temperature (T | 12-12-2013 |
Patent application number | Description | Published |
20090328239 | BLOOD VESSEL IMAGING AND USES THEREFOR - Methods are disclosed for analyzing representations of one or more structures in the body of a subject (e.g., a human subject or other animal subject) to glean information about the health of the subject or to evaluate the subject's response to a therapy or other condition. Aspects of the invention relate to obtaining structural information from casts (e.g., vascular casts from animal models) and using the information as a reference for evaluating structures in the body of a subject. Methods are disclosed for diagnosing, staging, grading, and monitoring diseases. Methods also are disclosed for targeting treatments, monitoring the effectiveness of therapies, and/or screening or validating therapies based analyzing structures (e.g., vascular structures) in a subject and comparing them to reference structures observed in casts obtained from models (e.g., animal models) of related diseases or conditions. | 12-31-2009 |
20110103657 | METHODS OF OBTAINING GEOMETRY FROM IMAGES - In one aspect, a method of detecting at least on feature associated with a blood vessel in at least one image of at least one blood vessel using a matched filter adapted to respond to the at least one feature is provided. The method comprises applying a scale detection filter to selected voxels in the at least one image to determine a scale for the matched filter at each of the selected voxels, determining an orientation for the matched filter at each of the selected voxels, wherein determining the orientation is assisted by using the scale determined at each of the selected voxels, applying the matched filter at each of the selected voxels at the scale and the orientation determined at each of the selected voxels to obtain a filter response at each of the selected voxels, and analyzing the filter response at each of the selected voxels to determine if the respective voxel corresponds to the at least one feature. | 05-05-2011 |
20120150048 | VASCULAR ANALYSIS METHODS AND APPARATUS - According to some aspects, a method of identifying a boundary of a portion of a vasculature is provided, the vasculature comprising a geometric representation of a plurality of vessels. The method comprises logically dividing the geometric representation into a plurality of regions, determining at least one feature within each of the plurality of regions, and defining the boundary of the portion of the vasculature based, at least in part, on the at least one feature determined within each of the plurality of regions, wherein the boundary forms a volume defining a separation between inside and outside of the portion of the vasculature. According to some aspects, a method of performing vascular analysis using a geometric representation of a plurality of vessels of the vasculature is provided. The method comprises computing a boundary of a portion of the vasculature based on the geometric representation, logically dividing the geometric representation within the boundary into a plurality of regions, and analyzing at least one feature for each of the plurality of regions within the boundary. | 06-14-2012 |
Patent application number | Description | Published |
20090199394 | Flexible Cathodes - This disclosure relates to methods of making a cathode for a lithium batter. The methods include: (a) treating a cathode current collector with flame or corona; (b) coating a slurry containing iron disulfide, a first solvent, and a binder onto the cathode current collector obtained from step (a) to form a coated cathode current collector, in which the slurry contains about 73-75% by weight solids and the binder contains a polymer selected from the group consisting of linear di- and tri-block copolymers, linear tri-block copolymers cross-linked with melamine resin, ethylene-propylene copolymers, ethylene-propylene-diene terpolymers, tri-block fluorinated thermoplastics, hydrogenated nitrile rubbers, fluoro-ethylene-vinyl ether copolymers, thermoplastic polyurethanes, thermoplastic olefins, and polyvinylidene fluoride homopolymers; and (c) drying the coated cathode current collector obtained from step (b) to provide a cathode, in which the cathode contains no more than 0.5% by volume of the first solvent and is capable of being bent to 180°. This disclosure also relates to methods of making a lithium battery. | 08-13-2009 |
20100236056 | Flexible Cathodes - This disclosure relates to methods of making a cathode for a lithium batter. The methods include: (a) treating a cathode current collector with flame or corona; (b) coating a slurry containing iron disulfide, a first solvent, and a binder onto the cathode current collector obtained from step (a) to form a coated cathode current collector, in which the slurry contains about 73-75% by weight solids and the binder contains a polymer selected from the group consisting of linear di- and tri-block copolymers, linear tri-block copolymers cross-linked with melamine resin, ethylene-propylene copolymers, ethylene-propylene-diene terpolymers, tri-block fluorinated thermoplastics, hydrogenated nitrile rubbers, fluoro-ethylene-vinyl ether copolymers, thermoplastic polyurethanes, thermoplastic olefins, and polyvinylidene fluoride homopolymers; and (c) drying the coated cathode current collector obtained from step (b) to provide a cathode, in which the cathode contains no more than 0.5% by volume of the first solvent and is capable of being bent to 180°. This disclosure also relates to methods of making a lithium battery. | 09-23-2010 |
20110254509 | Flexible Cathodes - This disclosure relates to methods of making a cathode for a lithium batter. The batterys include: (a) treating a cathode current collector with flame or corona; (b) coating a slurry containing iron disulfide, a first solvent, and a binder onto the cathode current collector obtained from step (a) to form a coated cathode current collector, in which the slurry contains about 73-75% by weight solids and the binder contains a polymer selected from the group consisting of linear di- and tri-block copolymers, linear tri-block copolymers cross-linked with melamine resin, ethylene-propylene copolymers, ethylene-propylene-diene terpolymers, tri-block fluorinated thermoplastics, hydrogenated nitrile rubbers, fluoro-ethylene-vinyl ether copolymers, thermoplastic polyurethanes, thermoplastic olefins, and polyvinylidene fluoride homopolymers; and (c) drying the coated cathode current collector obtained from step (b) to provide a cathode, in which the cathode contains no more than 0.5% by volume of the first solvent and is capable of being bent to 180°. This disclosure also relates to methods of making a lithium battery. | 10-20-2011 |
Patent application number | Description | Published |
20120082825 | METHODS OF WET ETCHING A SELF-ASSEMBLED MONOLAYER PATTERNED SUBSTRATE AND METAL PATTERNED ARTICLES - Method of patterning a substrate are described including a method of providing a substrate comprising a metalized surface having a self-assembled monolayer patterned region and unpatterned region; and wet etching the metalized surface in a liquid etchant agitated with bubbling gas to remove metal from the unpatterned regions to form a metal pattern. Also described are metal patterned article including an article comprising a substrate and an etched microcontact printed metal pattern disposed on the substrate wherein the pattern has a thickness of at least 100 nanometers and a pattern feature uniformity of at least 50% for an area of at least 25 cm | 04-05-2012 |
20130229194 | Sensor Element, Method of Making the Same, and Sensor Device Including the Same - A sensor element includes a first conductive electrode having a first conductive member electrically coupled thereto; an absorptive dielectric layer comprising a polymer of intrinsic microporosity; and a second conductive electrode having a second conductive member electrically coupled thereto. The second conductive electrode comprises at least one noble metal, has a thickness of from 4 to 10 nanometers and is permeable to at least one organic vapor. The absorptive dielectric layer is at least partially disposed between the first conductive electrode and the second conductive electrode. A method of making the sensor element, and sensor device containing it, are also disclosed. | 09-05-2013 |
20140021967 | METHOD OF DETECTING VOLATILE ORGANIC COMPOUNDS - A method of using a sensor element includes: exposing a sensor element to an unknown analyte vapor; measuring a capacitance of the sensor element to obtain a measured capacitance; obtaining a true capacitance of the sensor element; exposing the semi-reflective conductive electrode to incident light and observing reflected light in order to measure a spectral change between the incident light and the reflected light; comparing the true capacitance and the measured spectral change, or at least one derivative thereof, to a reference library, the reference library comprising reference correlations between spectral change and true capacitance, or at least one derivative thereof, for a plurality of reference analyte vapors; and determining at least one of the chemical class or identity of the analyte vapor. | 01-23-2014 |
20140025326 | ELECTRONIC DEVICE INCLUDING CALIBRATION INFORMATION AND METHOD OF USING THE SAME - Methods of generating a reference correlation for use with an absorptive capacitance vapor sensor and calibration of the absorptive capacitance vapor sensor. An electronic article including the reference correlation and methods of using the same are also disclosed. | 01-23-2014 |
20140111809 | SURFACE PLASMON RESONANCE SENSOR ELEMENT AND SENSOR INCLUDING THE SAME - A surface plasmon resonance sensor element includes a thin metallic layer, an optical construction disposed on the thin metallic layer for directing light to and away from the thin metallic layer, and an absorptive layer disposed on the thin metallic layer opposite the optical construction. The absorptive layer includes a polymer of intrinsic microporosity having an average pore volume of at least 0.4 cubic nanometers. | 04-24-2014 |
20140309947 | Method for Identification and Quantitative Determination of an Unknown Organic Compound in a Gaseous Medium - A method for identifying and quantitatively analyzing an unknown organic compound in a gaseous medium. More specifically, the method provides a gas sensor array ( | 10-16-2014 |
Patent application number | Description | Published |
20080292512 | METHOD FOR PRODUCING AND USING A CARBONACEOUS SORBENT FOR MERCURY REMOVAL - A method for removing mercury from flue gas comprises: applying a precursor of a sticky substance to surfaces of carbonaceous sorbent particles; injecting the carbonaceous sorbent particles into contact with flue gas, wherein the carbonaceous sorbent particles adsorb mercury from the flue gas and at least one of a temperature of the flue gas and a component of the flue gas changes the precursor into the sticky substance that increases the stickiness of the carbonaceous sorbent particles; and removing the carbonaceous sorbent particles having mercury adsorbed thereon from the flue gas. In one embodiment, the precursor is ammonia or an ammonia compound and the sticky substance is ammonium sulfate. The method may further comprise applying bromine or a bromine compound to the carbonaceous sorbent particles. | 11-27-2008 |
20090056538 | CONTROL OF MERCURY EMISSIONS FROM SOLID FUEL COMBUSTION - A method for removing mercury from flue gases generated by the combustion of coal comprises: storing a starter batch of activated carbon in an agglomerated state; de-agglomerating the starter batch in a separation device to create a contact batch of activated carbon; transporting the contact batch to a contact location; injecting the contact batch into contact with the flue gas at a contact location having a temperature between 400° F. and 1100° F., whereupon the activated carbon of the contact batch adsorbs mercury from the flue gas; and removing the activated carbon having mercury adsorbed thereon from the flue gas. The transporting step is conducted with substantially no intermediate storage of the contact batch following the de-agglomeration of the starter batch to prevent re-agglomeration of the activated carbon prior to injection. | 03-05-2009 |
20090320725 | FURNACE SYSTEM WITH INTERNAL FLUE GAS RECIRCULATION - A furnace system | 12-31-2009 |
20120145052 | APPARATUS AND METHOD OF CONTROLLING THE THERMAL PERFORMANCE OF AN OXYGEN-FIRED BOILER - Disclosed herein is a method of controlling the operation of an oxy-fired boiler; the method comprising combusting a fuel in a boiler; producing a heat absorption pattern in the boiler; discharging flue gases from the boiler; recycling a portion of the flue gases to the boiler; combining a first oxidant stream with the recycled flue gases to form a combined stream; splitting the combined stream into several fractions; and introducing each fraction of the combined stream to the boiler at different points of entry to the boiler. | 06-14-2012 |
20120178030 | SYSTEM AND METHOD FOR REDUCING EMISSIONS FROM A BOILER - A system and method for reducing emissions from a boiler. A boiler generally has a combustion area. The system further includes a fuel pipe for delivering fuel. The system further includes a conduit. A bore extends through the conduit. The bore of the conduit is in fluid communication with the fuel pipe and the combustion area of the boiler. A pre-ignition source is positioned in the conduit. The pre-ignition source operates to pre-ignite at least a portion of the fuel flowing through the conduit. | 07-12-2012 |
20130160857 | METHOD AND SYSTEM FOR TREATING AN EFFLUENT STREAM GENERATED BY A CARBON CAPTURE SYSTEM - A system for treating an effluent stream including a carbon capture system utilizing an amine-containing solution to remove carbon dioxide from a flue gas stream, the carbon capture system generating an effluent stream comprising degradation products generated by the amine-containing solution; storage means for storing at least a portion of the effluent stream, the storage means being fluidly coupled to the carbon capture system. The system also including at least one nozzle connected to a combustion zone of a boiler, the at least one nozzle being fluidly coupled to the storage means for providing at least a portion of the effluent stream present in the storage means to the combustion zone of the boiler through the at least one nozzle, wherein the effluent stream provided to the combustion zone is co-incinerated with a fuel in the combustion zone. | 06-27-2013 |
Patent application number | Description | Published |
20120182663 | ESD PROTECTION AGAINST CHARGE COUPLING - This document discusses among other things apparatus and methods for reducing ESD damage to buffer circuits. In an example, an output buffer can include an output, a first transistor configured to couple the output to a high logic supply rail, a second transistor configured to couple the output node to a low logic supply rail, pre-driver logic configured to drive a gate of the first transistor and a gate of the second transistor, and a first resistor configured to reduce electrostatic discharge (ESD) induced current between the first transistor and the pre-driver logic. | 07-19-2012 |
20120243132 | UNDERVOLTAGE PROTECTION SYSTEM - A system includes undervoltage protection circuitry coupled in parallel with electronic circuitry configured to receive a supply voltage from a power supply. The undervoltage protection circuitry is configured to shunt undervoltage current resulting from an undervoltage transient in the supply voltage away from the electronic circuitry | 09-27-2012 |
20120320481 | Protection System - Devices, systems and methods are provided for protecting electronic circuitry from voltage transients including undervoltage transients in a supply voltage. The device may include a first low voltage isolated transistor coupled in forward bias with respect to a power supply and a second low voltage isolated transistor coupled in series with the first low voltage isolated transistor and in reverse bias with respect to the power supply voltage. The device may further include a resistor coupled between a gate of the first low voltage isolated transistor and the power supply, the resistor configured to limit current flow to the gate of the first low voltage isolated transistor during an overvoltage event. | 12-20-2012 |
20140233139 | CLAMPING CIRCUIT AND DEVICE FOR EOS/SURGE/IEC - This application discusses, among other things, protection methods and apparatus for integrated circuits. In an example, an apparatus to protect a circuit from transient electrical events can include a protection transistor configured to couple a terminal of the circuit to a reference potential during the transient events, and one or more diodes coupled in series between the terminal and a control node of the protection transistor, the one or more diodes configured to trigger the protection transistor at a predetermined voltage of the terminal. In some examples, the apparatus does not include a clamp diode coupled between the control node of the protection transistor and the reference potential. | 08-21-2014 |