Albert, WI
Daniel M. Albert, Madison, WI US
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20100210734 | METHOD OF USING CALCITRIOL FOR TREATING INTRAOCULAR DISEASES ASSOCIATED WITH ANGIOGENESIS - The present invention provides a method of treating pathologies resulting from neovascular growth in the eye such as those manifested as retinopathy of prematurity, diabetic retinopathy and macular degeneration. The invention comprises the administration of an effective amount of calcitriol that is administered at doses less than toxicity and results in a significant reduction in the formation of neo-vascular growth. The invention can be used to treat existing diseases or prophylactically to treat those at risk. | 08-19-2010 |
Roger W. Albert, Plymouth, WI US
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20090120401 | Flywheel Assembly - A system for a flywheel assembly for use in conjunction with an internal combustion engine is disclosed. The flywheel assembly includes a flywheel in rotational association with a crankshaft of the internal combustion engine. The flywheel assembly further includes a cooling fan mounted over the flywheel, and capable of rotation therewith. The cooling fan and the flywheel are secured in a constant axial position relative to the crankshaft by virtue of a drive-cup and a retaining nut. Further, the flywheel includes a plurality of integrally formed, intersecting support ribs, for providing excellent dynamic stiffening (e.g., damping) capabilities to the flywheel assembly for substantially reducing and/or eliminating radiated noise. | 05-14-2009 |
20140271132 | NOISE SUPPRESSION SYSTEM - A noise suppression system for an air-cooled internal combustion engine is disclosed. The system may include an acoustically designed shroud forming a cavity and configured for attenuating noise produced by a cooling air fan associated with the engine. In one system, the shroud is mountable on a housing of the air fan. A pair of air inlet passages may be provided which are operable to draw ambient cooling air into the shroud to the fan. The air inlet passages are acoustically configured and tuned to attenuate noise generated by the fan. In one system, the air inlet passages may each be formed in a rear quadrant of the shroud. Various configurations of the shroud may include quarter wave resonators and/or micro-perforated panels to further attenuate fan noise. | 09-18-2014 |
Thomas Albert, Fitchburg, WI US
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20090105081 | METHODS AND SYSTEMS FOR SOLUTION BASED SEQUENCE ENRICHMENT - The present invention provides methods and systems for the capture and enrichment of target nucleic acids and analysis of the enriched target nucleic acids. In particular, the present invention provides for the enrichment of targeted sequences in a solution based format. | 04-23-2009 |
20090221438 | METHODS AND SYSTEMS FOR UNIFORM ENRICHMENT OF GENOMIC REGIONS - The present invention provides methods and compositions for the enrichment of target nucleic acids in a microarray system. In particular, the present invention provides methods and compositions for uniform enrichment of target nucleic acid molecules in a microarray format. The present invention also provides for intentionally non-uniform enrichment among target nucleic acid molecules. | 09-03-2009 |
20090246788 | Methods and Assays for Capture of Nucleic Acids - The present disclosure provides methods and systems for sequence specific nucleic acid target capture comprising enzymatic reactions. The present disclosure relates to a plurality of oligonucleotide probes for capture and subsequent detection of target nucleic acid sequences, using flap endonucleases, ligases, and/or additional enzymes, proteins or compounds, on substrates, for example microarray slides, and in solution formats. | 10-01-2009 |
20120046175 | METHODS AND SYSTEMS FOR SOLUTION BASED SEQUENCE ENRICHMENT - The present invention provides methods and systems for the capture and enrichment of target nucleic acids and analysis of the enriched target nucleic acids. In particular, the present invention provides for the enrichment of targeted sequences in a solution based format. | 02-23-2012 |
20120071357 | METHODS AND SYSTEMS FOR UNIFORM ENRICHMENT OF GENOMIC REGIONS - The present invention provides methods and compositions for the enrichment of target nucleic acids in a microarray system. In particular, the present invention provides methods and compositions for uniform enrichment of target nucleic acid molecules in a microarray format. The present invention also provides for intentionally non-uniform enrichment among target nucleic acid molecules. | 03-22-2012 |
Thomas Albert, Verona, WI US
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20100331204 | METHODS AND SYSTEMS FOR ENRICHMENT OF TARGET GENOMIC SEQUENCES - The present invention provides methods and systems for targeted nucleic acid sequence enrichment in a sample. In particular, the present invention provides for enriching for targeted nucleic acid sequences during hybridizations in hybridization assays by first depleting non-target nucleic acid sequences. | 12-30-2010 |
Thomas Albert, Madison, WI US
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20090203540 | Methods and Systems for Quality Control Metrics in Hybridization Assays - The present invention provides methods and systems for performing quality control metrics in hybridization assays. In particular, the present invention provides for quality control metrics for nucleic acid enrichment on hybridization assay formats, such as microarray assays. | 08-13-2009 |
20100167952 | SUPPRESSION OF SECONDARY CAPTURE IN MICROARRAY ASSAYS - The present invention provides for compositions, methods and systems for targeted sequence enrichment. In particular, the present invention provides for enriching for targeted nucleic acid sequences during hybridizations in microarray assays by suppressing secondary capture of non-target nucleic acid sequences. | 07-01-2010 |
Thomas J. Albert, Verona, WI US
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20110003701 | System and method for improved processing of nucleic acids for production of sequencable libraries - An embodiment of an adaptor element for efficient target processing is described that comprises a semi-complementary double stranded nucleic acid adaptor comprising a non-complementary region and a complementary region, where the non-complementary region comprises a first amplification primer site and a second amplification primer site and the complementary region comprises a sequencing primer site and one or more inosine species. | 01-06-2011 |
Thomas J. Albert, Fitchburg, WI US
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20100222232 | ENRICHMENT AND SEQUENCE ANALYSIS OF GENOMIC REGIONS - The present invention provides novel methods for reducing the complexity of preferably a genomic sample for further analysis such as direct DNA sequencing, resequencing or SNP calling. The methods use pre-selected immobilized oligonucleotide probes to capture target nucleic acid molecules from a sample containing denatured, fragmented (genomic) nucleic acids for reducing the genetic complexity of the original population of nucleic acid molecules. | 09-02-2010 |
20110184161 | USE OF MICROARRAYS FOR GENOMIC REPRESENTATION SELECTION - The present invention provides novel methods for reducing the complexity of a genomic sample for further analysis such as direct DNA sequencing, resequencing or SNP calling. The methods use pre-selected immobilized oligonucleotide probes to capture target nucleic acid molecules from a sample containing denatured, fragmented genomic nucleic acid. The disclosed method provides for cost-effective, flexible and rapid enrichment of target nucleic acid from complex biological samples. | 07-28-2011 |
Tom Albert, Verona, WI US
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20120238477 | METHODS FOR SYNTHESIS OF AN OLIGOPEPTIDE MICROARRAY - An oligopeptide microarray and methods for the synthesis thereof are presented. Further presented is a microarray on a solid support comprising at least about 10,000 oligopeptide features per cm | 09-20-2012 |
20120245057 | WHOLE PROTEOME TILING MICROARRAYS - The present invention relates to a microarray comprising at least 50,000 oligopeptide features per cm | 09-27-2012 |