Patent application number | Description | Published |
20080262096 | Squaric Acid Derivatives - Novel squaric acid compounds of the formula (I), in which R, R | 10-23-2008 |
20080293719 | Pyridiazinone Derivatives for the Treatment of Tumours - Compounds of the formula (I), in which R | 11-27-2008 |
20080306052 | 3, 6-Dihydro-2-Oxo-6H-1,3,4,-Thiadiazine Derivatives - Compounds of the formula I, in which R1, R2, Q and B have the meanings indicated in claim | 12-11-2008 |
20080312278 | Hydroxyquinoline Derivatives - Compounds of the formula I in which X, Y, R | 12-18-2008 |
20080318936 | Substituted 5-Phenyl-3,6-Dihydro-2-Oxo-6H-1,3,4-Thiadiazines -
Compounds of the formula (I), in which R | 12-25-2008 |
20090036449 | Indazolesquaric Acid Derivatives as Chk1, Chk2 and Sgk Inhibitors - Novel squaric acid compounds of the formula (I), in which R, R1, R2, R2′, R2″, R3, B, B′ and X have the meanings indicated in Claim | 02-05-2009 |
20100173923 | 4 (PYRROLOPYRIDINYL)PYRIMIDINYL-2-AMINE DERIVATIVES - Compounds of the formula I in which R | 07-08-2010 |
20100179148 | PYRIDAZINONE DERIVATIVES - Compounds of the formula (I), in which R | 07-15-2010 |
20100179149 | ARYL ETHER PYRIDAZINONE DERIVATIVES - Compounds of the formula I, in which R | 07-15-2010 |
20100197690 | Pyrimidinyl Pyridazinone Derivatives - Compounds selected from the group according to Claim | 08-05-2010 |
20100210864 | PROCESS FOR THE PREPARATION OF N-ARYLMORPHOLINONES - Process for the preparation of compounds of the formula (I) in which X has the meaning indicated in Patent Claim | 08-19-2010 |
20100234354 | PYRIDAZINONE DERIVATIVES - Compounds of the formula (I), in which R | 09-16-2010 |
20100261697 | 2-(HETEROCYCLYLBENZYL)PYRIDAZINONE DERIVATIVES - Compounds of the formula (I) in which R | 10-14-2010 |
20100273796 | 2-BENZYLPYRIDAZINONE DERIVATIVES AS MET KINASE INHIBITORS - Compounds of the formula I | 10-28-2010 |
20100280030 | 2-OXO-3-BENZYLBENZOXAZOL-2-ONE DERIVATIVES AND RELATED COMPOUNDS AS MET KINASE INHIBITORS FOR THE TREATMENT OF TUMOURS - Compounds of the formula (I), in which R | 11-04-2010 |
20100292262 | 4 (PYRROLO[2,3-C]PYRIDINE-3-YL)PYRIMIDIN-2-AMINE DERIVATIVES - Compounds of the formula (I), in which R | 11-18-2010 |
20100311733 | THIADIAZINONE DERIVATIVES - Compounds of the formula (I), in which R | 12-09-2010 |
20110034474 | PYRIDAZINONE DERIVATIVES - Compounds of the formula (I), in which R | 02-10-2011 |
20110071153 | DIHYDROPYRAZOLE DERIVATIVES AS TYROSINE KINASE MODULATORS FOR THE TREATMENT OF TUMORS - Compounds of the formula I, in which R | 03-24-2011 |
20110082140 | 6-(PYRROLOPYRIDINYL) PYRIMIDIN-2-YLAMINE DERIVATIVES AND THE USE THEREOF FOR THE TREATMENT OF CANCER AND AIDS. - Compounds of the formula (I), in which R | 04-07-2011 |
20110092498 | 3-(3-PYRIMIDIN-2-YLBENZYL)-1,2,4-TRIAZOLO[4,3-B]PYRIDAZINE DERIVATIVES AS MET KINASE INHIBITORS - Compounds of the formula (I), in which R | 04-21-2011 |
20110092527 | 4 (Pyrrolopyridinyl)pyrimidin-2-ylamine derivatives - Compounds of the formula (I), in which R | 04-21-2011 |
20110135600 | BICYCLIC TRAIZOLE DERIVATIVES FOR TREATING OF TUMORS - Compounds of the formula (I), in which X | 06-09-2011 |
20110136819 | 6-THIOXOPYRIDAZINE DERIVATIVES - Compounds of the formula I, in which R | 06-09-2011 |
20110218198 | Pyrrolopyridinylpyrimidin-2-ylamine derivatives - Compounds of the formula I in which X, R | 09-08-2011 |
20110257172 | 3-(3-Pyrimidine-2-yl-benzyl)-[1,2,4] triazolo[4,3-b]pyrimidine derivatives - Compounds of the formula I, in which R | 10-20-2011 |
20110257173 | 3 (3-Pyrimidin-2-ylbenzyl)-1,2,4-triazolo[4,3-b]pyridazine derivatives - Compounds of the formula (I), in which R | 10-20-2011 |
20110257180 | Novel Polymorphic Forms of 6-(1-methyl-1H-pyrazol-4-yl)-2--2H-pyridazin-3-one Dihydrogenphosphate and Processes of Manufacturing thereof - The present invention relates to 6-(1-methyl-1H-pyrazol-4-yl)-2-{3-[5-(2-morpholin-4-yl-ethoxy)-pyrimidin-2-yl]-benzyl}-2H-pyridazin-3-one dihydrogenphosphate, its solvates and crystalline modifications thereof. The present invention further relates to processes of manufacturing these crystalline modifications as well as their use in the treatment and/or prophylaxis of physiological and/or pathophysiological conditions, which are caused, mediated and/or propagated by the inhibition, regulation and/or modulation of signal transduction of kinases, in particular by the inhibition of tyrosine kinases, e.g. pathophysiological conditions such as cancer. | 10-20-2011 |
20110257181 | PYRIDAZINONE DERIVATIVES - Compounds of the formula (I), in which Y, R | 10-20-2011 |
20110263596 | 2-OXO-3-BENZYLBENZOXAZOL-2-ONE DERIVATIVES AND RELATED COMPOUNDS AS MET KINASE INHIBITORS FOR THE TREATMENT OF TUMOURS - Described are compounds which inhibit, regulate and/or modulate kinase signal transduction, for example of Met kinase. The compounds are of the formulae A1 to A148 and B1 described herein, including 2-oxobenzoxazol-3-ylmethyl]phenyl}carbamate and 2-oxooxazolo[4,5-b]pyridin-3-ylmethyl)phenyl]carbamate compounds, and pharmaceutically usable salts, tautomers and stereoisomers thereof, including mixtures thereof in all ratios. Also described are compositions containing these compounds. Also described are methods for the treatment of diseases in which the inhibition, regulation and/or modulation of kinase signal transduction plays a role by administering these compounds. | 10-27-2011 |
20110269756 | BENZOTHIAZOLONE DERIVATIVES - Compounds of the formula I, in which R | 11-03-2011 |
20110269765 | Pyridazinone derivatives - Compounds of the formula (I) in which D, R | 11-03-2011 |
20110269767 | Novel Polymorphic Forms of 3-(1--6-oxo-1,6-dihydro-pyridazin-3-yl)-benzonitrile Hydrochloride Salt and Processes of Manufacturing Thereof - The present invention relates to 3-(1-{3-[5-(1-methyl-piperidin-4-ylmethoxy)-pyrimidin-2-yl]-benzyl}-6-oxo-1,6-dihydro-pyridazin-3-yl)-benzonitrile hydrochloride solvates and crystalline modifications thereof. The present invention further relates to processes of manufacturing these crystalline modifications as well as their use in the treatment and/or prophylaxis of physiological and/or pathophysiological conditions, which are caused, mediated and/or propagated by the inhibition, regulation and/or modulation of signal transduction of kinases, in particular by the inhibition of tyrosine kinases, e.g. pathophysiological conditions such as cancer. | 11-03-2011 |
20120101095 | ALKOXY-THIENOPYRIMIDINES AS TGF-BETA RECEPTOR KINASE MODULATORS - Novel alkoxy-thienopyrimidine derivatives of formula (I) | 04-26-2012 |
20120264999 | 4 (PYRROLOPYRIDINYL)PYRIMIDIN-2-YLAMINE DERIVATIVES - Compounds of the formula (I), in which R | 10-18-2012 |
20120295902 | Hetaryl-[1,8]naphthyridine derivatives - Novel hetaryl-[1,8]naphthyridine derivatives of formula (I) | 11-22-2012 |
20120295908 | PYRIMIDINYL PYRIDAZINONE DERIVATIVES - Compounds selected from the group according to claim | 11-22-2012 |
20120316166 | HETARYLAMINONAPHTHYRIDINES - Novel hetarylaminonaphthyridine derivatives of formula (I) | 12-13-2012 |
20130102603 | 2,4-DIARYL - SUBSTITUTED [1,8] NAPHTHYRIDINES AS KINASE INHIBITORS FOR USE AGAINST CANCER - The present invention relates to novel [1,8]naphthyridine derivatives of formula (I) and to the use of such compounds in which the inhibition, regulation and/or modulation of signal transduction by ATP consuming proteins like kinases plays a role, particularly to inhibitors of TGF-beta receptor kinases, and to the use of such compounds for the treatment of kinase-induced diseases, in particular for the treatment of tumors. | 04-25-2013 |
20130102608 | BIPYRIDYL DERIVATIVES - The present invention relates to novel bipyridyl derivatives of formula (I) and to the use of such compounds in which the inhibition, regulation and/or modulation of signal transduction by ATP consuming proteins like kinases plays a role, particularly to inhibitors of TGF-beta receptor kinases, and to the use of such compounds for the treatment of kinase-induced diseases, in particular for the treatment of tumors. | 04-25-2013 |
20130131037 | 2-(HETEROCYCLYLBENZYL)PYRIDAZINONE DERIVATIVES - Compounds of the formula (I), in which R | 05-23-2013 |
20130184260 | PYRIDAZINONE DERIVATIVES - Compounds of the formula (I), in which R | 07-18-2013 |
20130184261 | PYRIDAZINONE DERIVATIVES - Compounds of the formula (I), in which R | 07-18-2013 |
20130190311 | Pyridazinone derivatives - Compounds of the formula I | 07-25-2013 |
20130217951 | 7-(1,2,3-TRIAZOL-4-YL) PYRROLO [2,3-B] PYRAZINE DERIVATIVES - Compounds of the formula (I), in which R | 08-22-2013 |
20130289017 | 5 (1,2,3-TRIAZOL-4-YL)-7H-PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES - Compounds of the formula (I), in which R | 10-31-2013 |
20130310391 | 7-AZAINDOLE DERIVATIVES - Compounds of the formula (I) in which R, R | 11-21-2013 |
20130345227 | PYRIDO [2, 3 - B] PYRAZINE DERIVATIVES AND THEIR THERAPEUTICAL USES - The present invention relates to novel pyrido[2,3-b]pyrazine derivatives of formula (I) and to the use of such compounds in which the inhibition, regulation and/or modulation of signal transduction by ATP consuming proteins like kinases plays a role, particularly to inhibitors of TGF-beta receptor kinases, and to the use of such compounds for the treatment of kinase-induced diseases, in particular for the treatment of tumors. | 12-26-2013 |
20140038960 | Hetaryl-[1,8]naphthyridine derivatives - Novel hetaryl-[1,8]naphthyridine derivatives of formula (I) | 02-06-2014 |
20140128396 | PYRIMIDINYL PYRIDAZINONE DERIVATIVES - Compounds selected from the group according to Claim | 05-08-2014 |
20140148463 | PYRIDAZINONE DERIVATIVES - Compounds of the formula (I) in which D, R | 05-29-2014 |
20140200221 | NOVEL POLYMORPHIC FORMS OF 3-(1--6-OXO-1,6-DIHYDRO-PYRIDAZIN-3-YL)-BENZONITRILE HYDROCHLORIDE SALT AND PROCESSES OF MANUFACTURING THEREOF - The present invention relates to 3-(1-{3-[5-(1-methyl-piperidin-4-ylmethoxy)-pyrimidin-2-yl]-benzyl}-6-oxo-1,6-dihydro-pyridazin-3-yl)-benzonitrile hydrochloride solvates and crystalline modifications thereof. The present invention further relates to processes of manufacturing these crystalline modifications as well as their use in the treatment and/or prophylaxis of physiological and/or pathophysiological conditions, which are caused, mediated and/or propagated by the inhibition, regulation and/or modulation of signal transduction of kinases, in particular by the inhibition of tyrosine kinases, e.g. pathophysiological conditions such as cancer. | 07-17-2014 |
20140323481 | 3-CYANOARYL-1H-PYRROLO[2,3-B]PYRIDINE DERIVATIVES - Compounds of the formula (I) in which R | 10-30-2014 |
20140336201 | BIPYRIDYL DERIVATIVES - The present invention relates to novel bipyridyl derivatives of formula (I) and to the use of such compounds in which the inhibition, regulation and/or modulation of signal transduction by ATP consuming proteins like kinases plays a role, particularly to inhibitors of TGF-beta receptor kinases, and to the use of such compounds for the treatment of kinase-induced diseases, in particular for the treatment of tumors. | 11-13-2014 |
20140378431 | TRIAZOLO[4,5-D]PYRIMIDINE DERIVATIVES - Compounds of the formula I | 12-25-2014 |
20150057264 | BICYCLIC PYRAZINONE DERIVATIVES - Compounds of the formula I | 02-26-2015 |