Leslie C.
Leslie C. Beadling, South Plainfield, NJ US
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20100204461 | Bimolecular Constructs - An immobilized bimolecular construct comprises a solid support, a first oligonucleotide and a second oligonucleotide. The first oligonucleotide is labeled at one end with a fluorophore or quencher and attached at the other end to a solid support. The second oligonucleotide is labeled at one end with a fluorophore or quencher and hybridized at the other end to the first oligonucleotide. Hybridization of the second oligonucleotide with the first oligonucleotide brings the labeled end of the second oligonucleotide in close proximity or physical contact with the labeled end of the first oligonucleotide. In one embodiment the second oligonucleotide is also attached to the solid support in proximity to the first oligonucleotide. In this embodiment, the second oligonucleotide may be first attached to the solid support and then hybridized to the first oligonucleotide or, conversely, first hybridized to the first oligonucleotide and then attached to the solid support. | 08-12-2010 |
20100233678 | TUNABLE AFFINITY LIGANDS FOR THE SEPARATION AND DETECTION OF TARGET SUBSTANCES - Conformationally tunable affinity ligands are rationally designed and selected for the ability to switch under operator-defined environmental conditions between or among structurally distinct states that have different affinities for a given target substance. Tunable affinity ligands are incorporated into reagents, separation media, assays, sensors, devices, kits and systems for sorting, separating, detecting, sensing, quantifying, identifying and monitoring target substances. Applications include biomedical research, diagnostics, drug discovery, bioproduction and processing and environmental, industrial, chemical, agricultural and military use. | 09-16-2010 |
20100233714 | MULTISTATE AFFINITY LIGANDS FOR THE SEPARATION AND PURIFICATION OF ANTIBODIES, ANTIBODY FRAGMENTS AND CONJUGATES OF - Separation of antibodies, antibody fragments, and conjugates thereof using multistate affinity ligands rationally designed and selected to undergo analytically and functionally definable conformational transitions from a first affinity state under a first operator-defined environmental condition to a second affinity state under a second operator-defined environmental condition. | 09-16-2010 |
Leslie C. Beadling, Wilmington, DE US
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20140303015 | Molecular Constructs for Differentiating a Target Molecule from an Off-Target Molecule - Molecular constructs, populations thereof, arrays, compositions, methods and kits for differentiating a target molecule from an off-target molecule are provided. | 10-09-2014 |
Leslie C. Marchion, Newtown, PA US
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20100158415 | Pop-In's waste basket liners - People purchase decorative wastebaskets to match the color and design scheme of the room where the wastebasket will be used. For cleanness and comfort of waste disposal, people line the wastebasket with a waste bag. Unfortunately, part of the outside decorative surface of the wastebasket is hidden by the waste bag, thus, defeating the purpose of having a decorative wastebasket. The present invention solves this problem by providing a solution for properly lining the wastebasket but not hiding it. | 06-24-2010 |
Leslie C. Smith, Crassier CH
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20130224132 | COLOURING PRE-MIX FOR USE IN COLOURING OF A COSMETIC COMPOSITION - The present invention provides a colouring pre-mix for use in colouring of a cosmetic composition and a coloured cosmetic composition including the same, wherein the colouring pre-mix includes 45-80 wt-% benzyl benzoate; 20-49 wt-% dipropylene glycol; 0.00001-5 wt-% colouring plant extracts; and optionally 0.00001-5 wt-% colorants; with the provision that the content of benzyl benzoate exceeds the content of dipropylene glycol, wherein all data given in wt-% refer to the total weight of the colouring pre-mix. | 08-29-2013 |