Bowers, MA
Albert Bowers, Boston, MA US
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20100029731 | Method for preparing largazole analogs and uses thereof - Analogs of largazole are described herein. Methods of treating cancer and blood disorders using largazole and largazole analogs and pharmaceutical compositions comprising the same are additionally described herein. Methods for preparing largazole analogs are likewise described. | 02-04-2010 |
20120264794 | Method for Preparing Largazole Analogs and Uses Thereof - Analogs of largazole are described herein. Methods of treating cancer and blood disorders using largazole and largazole analogs and pharmaceutical compositions comprising the same are additionally described herein. Methods for preparing largazole analogs are likewise described. | 10-18-2012 |
20140093449 | Method for Preparing Largazole Analogs and Uses Thereof - Analogs of largazole are described herein. Methods of treating cancer and blood disorders using largazole and largazole analogs and pharmaceutical compositions comprising the same are additionally described herein. Methods for preparing largazole analogs are likewise described. | 04-03-2014 |
Albert A. Bowers, Somerville, MA US
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20090163697 | Multicomponent coupling and glycopeptide synthesis with cyclic thioanhydrides - Disclosed is a method of coupling an amino or hydroxyl compound with the amino portion of a sulfonamide via condensation with a cyclic thioanhydride. The reaction of cyclic thioanhydrides with amines affords amides functionalized with thioacids, which can be trapped in situ with preferably electron deficient arylsulfonamides. In this manner the cyclic thioanhydride serves as a linchpin in a three component coupling sequence. | 06-25-2009 |
Brian J. Bowers, Cambridge, MA US
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20130236804 | COOLING SYSTEM AND METHOD FOR USE WITH A FUEL CELL - A cooling system is provided for use with a fuel cell. The cooling system comprises a first heat exchanger fluidly connected to an outlet passage of the fuel cell. The first heat exchanger can be configured to condense at least a portion of a fluid passing through the outlet passage of the fuel cell into liquid water. The cooling system can also comprise a second heat exchanger fluidly connected to an outlet passage of the first heat exchanger and an inlet passage of the fuel cell. The second heat exchanger can be configured to cool a fluid passing into the inlet passage of the fuel cell. In addition, the outlet passage of the fuel cell and the inlet passage of the fuel cell can be fluidly connected to a cathode of the fuel cell, and the inlet passage of the fuel cell can be configured to supply water to the cathode. | 09-12-2013 |
Jayson Bowers, Cambridge, MA US
Patent application number | Description | Published |
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20090061437 | Nucleotide Analogs - The invention provides for nucleotide analogs and methods of using the same, e.g., for sequencing nucleic acids. | 03-05-2009 |
20100190168 | COMPETITOR MOLECULES USEFUL FOR LOWERING NONSPECIFIC ADSORPTION OF DYE LABELED NUCLEOTIDES - Methods are described which enable higher signal/noise when performing surface measurements at the single molecule level. Methods are particularly useful in the field of molecular biology when performing single molecule nucleic acid sequencing by synthesis using dye labeled nucleotides. The method employs using a competitor molecule which blocks nonspecific binding of analog molecules to the surface. | 07-29-2010 |
20100233696 | METHODS, FLOW CELLS AND SYSTEMS FOR SINGLE CELL ANALYSIS - A method, flow cell and/or device for increasing the recovery of a limiting analyte in a sample, e.g., for single molecule analysis is disclosed. Methods for preparing a nucleic acid sample from a single cell and capturing nucleic acids on a surface configured for use in or with single molecule analysis are also provided. | 09-16-2010 |
20110081647 | NUCLEOTIDE ANALOGS - The invention generally relates to nucleotide analogs and methods of their use in sequencing-by-synthesis reactions. In certain embodiments, the invention provides a nucleotide analog including a detectable label attached to a nitrogenous base portion of a nucleotide analog by a cleavable linker, in which contact of the analog with at least one activating agent results in cleavage of the label and elimination of the linker, thereby producing a natural nucleotide, a 9-deaza-G, 9-deaza-A, or ψ-uridine. | 04-07-2011 |
20120028822 | METHODS, FLOW CELLS AND SYSTEMS FOR SINGLE CELL ANALYSIS - A method, flow cell and/or device for increasing the recovery of a limiting analyte in a sample, e.g., for single molecule analysis is disclosed. Methods for preparing a nucleic acid sample from a single cell and capturing nucleic acids on a surface configured for use in or with single molecule analysis are also provided. | 02-02-2012 |
20120040340 | NUCLEOTIDE ANALOGS - The invention provides for nucleotide analogs and methods of using the same, e.g., for sequencing nucleic acids. | 02-16-2012 |
Jayson L. Bowers, Cambridge, MA US
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20100203524 | POLYMERASES AND METHODS OF USE THEREOF - The invention generally relates to polymerases for efficient and controlled sequencing-by-synthesis reactions. In certain embodiments, the invention provides a polymerase enzyme including at least one mutation that enhances ability of the polymerase as compared to a wild-type polymerase to incorporate a nucleotide into a nascent strand of DNA or cDNA including at least one modified nucleotide. | 08-12-2010 |
Jayson Linn Bowers, Cambridge, MA US
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20140302487 | Recombinant Phage and Bacterial Detection Methods - Methods of detecting target bacteria are provided. In some embodiments the methods comprise exposing the sample to a phage capable of infecting a set of target bacteria and comprising a heterologous nucleic acid sequence encoding a marker. In some embodiments the target bacteria comprise | 10-09-2014 |
Kevin D. Bowers, Melrose, MA US
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20150242616 | Credential recovery with the assistance of trusted entities - There is disclosed a method for use in credential recovery. In one exemplary embodiment, the method comprises determining a policy that requires at least one trusted entity to verify the identity of a first entity in order to facilitate credential recovery. The method also comprises receiving at least one communication that confirms verification of the identity of the first entity by at least one trusted entity. The method further comprises permitting credential recovery based on the received verification. | 08-27-2015 |
Kyle R. Bowers, Boxborough, MA US
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20100234700 | WIRELESS MONITORING APPARATUS USED IN CONJUNCTION WITH AN AUTOMATED EXTERNAL DEFIBRILLATOR (AED) SYSTEM FOR MULTIPLE PATIENT RESCUE DURING MASS CASUALTY INCIDENTS - A Wireless Monitoring Apparatus is used in conjunction with an automated external defibrillator (AED) system for patient rescue in mass-casualty incidents. The rescuer applies the device on each patient. The wireless monitoring apparatus automatically analyzes the patient's heart rhythm and communicates with the AED system. The AED system is therefore is able to display information with regard to each patient, notifies the rescuer on actions to take and can deliver defibrillation therapy if needed. | 09-16-2010 |
20110130665 | METHOD AND SYSTEM FOR EXPEDITING THE RESCUE OF VICTIMS EXPERIENCING SUDDEN CARDIAC ARREST (SCA) WHEN USED IN CONJUNCTION WITH AN AUTOMATED EXTERNAL DEFIBRILLATOR (AED) - A method and system for expediting the rescue of victims experiencing sudden cardiac arrest (SCA) when used in conjunction with an automated external defibrillator (AED). The system involves an apparatus that calls for help (i.e. 911), detects SCA and cardiac arrhythmias, locates an AED, guides the rescuer through CPR and connection of the AED. A second apparatus is in the enclosure that contains the AED, sends location information to the other apparatus, triggers audible and visual indicators, and provides information on the victim's location. | 06-02-2011 |
20120010673 | Method and apparatus for determining battery capacity in a defibrillator - A defibrillator system and associated methodology for determining capacity of a battery and/or a number of battery cells contained in a pack. The system measures and stores the battery or battery pack voltage signal data and uses an algorithm to determine the remaining capacity. The algorithm takes into account the operating mode of the device, historical information of the device including, but not limited to, how long it has been since the device has been used, how the device has been used (e.g. shocking mode or idle mode), how many times the device has been used with its installed battery or battery pack, how many charging cycles and/or shocks have been delivered etc. The output from the system is fed back to the user to inform the user when the battery is low, needs to be replaced and/or how many remaining shocks are left the battery. | 01-12-2012 |
20140243610 | WIRELESS MONITORING APPARATUS USED IN CONJUNCTION WITH AN AUTOMATED EXTERNAL DEFIBRILLATOR (AED) SYSTEM FOR MULTIPLE PATIENT RESCUE DURING MASS CASUALTY INCIDENTS - A Wireless Monitoring Apparatus is used in conjunction with an automated external defibrillator (AED) system for patient rescue in mass-casualty incidents. The rescuer applies the device on each patient. The wireless monitoring apparatus automatically analyzes the patient's heart rhythm and communicates with the AED system. The AED system is therefore is able to display information with regard to each patient, notifies the rescuer on actions to take and can deliver defibrillation therapy if needed. | 08-28-2014 |
Simeon Bowers, Cambridge, MA US
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20150284337 | INHIBITORS OF LRRK2 KINASE ACTIVITY - The present invention provides compounds having a structure according to Formula I: (I) or a salt or solvate thereof, wherein R1, R2, R3 and R4 are defined herein. The invention further provides pharmaceutical compositions including the compounds of the invention and methods of making and using the compounds and compositions of the invention, e.g., in the treatment and prevention of various disorders, such as Parkinson's disease. | 10-08-2015 |
William Bowers, Topsfield, MA US
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20100173330 | IMMUNOASSAY ASSEMBLY AND METHODS OF USE - The present invention relates to an improved system for efficiently and accurately performing immunoassays, such as ELISAs. The invention provides an immunoassay assembly which includes a flow-through unit and an aspiration pump. The immunoassay flow-through unit includes an outer seal; at least one bed support; an inner seal; and a packed non-porous bed. The unit is releasably attached to an aspiration pump which enables the controlled flow rate of liquid passing through the packed bed of the flow-through unit. The invention also provides a method of using the immunoassay assembly to identify analytical targets of interest. | 07-08-2010 |
20100323372 | IMMUNOASSAY ASSEMBLY AND METHODS OF USE - The present invention relates to an improved system for efficiently and accurately performing immunoassays, such as ELISAs. The invention provides an immunoassay assembly which includes a flow-through unit and an aspiration pump. The immunoassay flow-through unit includes an outer seal; at least one bed support; an inner seal; and a packed non-porous bed. The unit is releasably attached to an aspiration pump which enables the controlled flow rate of liquid passing through the packed bed of the flow-through unit. The invention also provides a method of using the immunoassay assembly to identify analytical targets of interest. | 12-23-2010 |