Chung, MA
Brice Hoani Valentin Chung, Cambridge, MA US
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20140014503 | High Temperature Sealed Electrochemical Cell - A cell for high temperature electrochemical reactions is provided. The cell includes a container, at least a portion of the container acting as a first electrode. An extension tube has a first end and a second end, the extension tube coupled to the container at the second end forming a conduit from the container to said first end. A second electrode is positioned in the container and extends out of the container via the conduit. A seal is positioned proximate the first end of the extension tube, for sealing the cell. | 01-16-2014 |
Brice H.v. Chung, Boston, MA US
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20140272481 | High Amperage Batteries with Displacement Salt Electrodes - An electrochemical cell includes a negative electrode comprising a first active metal, a positive electrode comprising a second active metal, and an electrolyte comprising salts of the two active metals, a salt of the cathodic metal and a salt of the anodic metal. In operation, the electrolyte composition varies such that in a charging mode the salt of the anodic salt decreases, while the salt of the cathodic salt increases, and in a discharging mode the salt of the anodic salt increases, while the salt of the cathodic salt decreases. The cell is operational for both storing electrical energy and as a source of electrical energy as part of an uninterruptible power system. The cell is particularly suited to store electrical energy produced by an intermittent renewable energy source. | 09-18-2014 |
Chee Yeun Chung, Belmont, MA US
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20110129527 | RAB3B FOR THE TREATMENT AND PREVENTION OF PARKINSON'S DISEASE - The invention features methods and compositions for the treatment and prevention of Parkinson's Disease. | 06-02-2011 |
Chee-Yeun Chung, Cambridge, MA US
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20100203111 | G-SUBSTRATE FOR THE TREATMENT AND PREVENTION OF PARKINSON'S DISEASE - The invention features methods and compositions for the treatment and prevention of Parkinson's Disease. | 08-12-2010 |
20160041149 | CELLULAR DISCOVERY PLATFORM FOR NEURODEGENERATIVE DISEASES - In some aspects, a cross-species platform useful for drug discovery in neurodegenerative diseases is described. | 02-11-2016 |
Daniel C. Chung, Cambridge, MA US
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20080306002 | Combination Therapy for Preventing Angiogenesis - The present invention is directed to a combination therapy for inhibiting angiogenesis in a subject having, or at risk of having, an angiogenic disease/disorder. The method comprises both administering to the mammal an inhibitor of HIF-I and administering a second compound or agent that inhibits angiogenesis such as an inhibitor of IL-8, VEGF, angiopoietins, EGF, FGF, TGF, G-CSF, or PDGF. Administration of an inhibitor of hypoxia inducible factor-1 (HIF-I) in combination with an inhibitor of interleukin 8 (IL-8) is particularly useful for treatment of colon cancer, lung cancer, pancreatic cancer, and breast cancer. | 12-11-2008 |
Dong Won Chung, Sturbridge, MA US
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20080292990 | Electronic device manufacture - New methods are provided for manufacturing a semiconductor device. Preferred methods of the invention include depositing a photoresist on a semiconductor substrate surface followed by imaging and development of resist coating layer; applying a curable organic or inorganic composition over the resist relief image; etching to provide a relief image of the resist encased by the curable composition; and removing the resist material whereby the curable organic or inorganic composition remains in a relief image of increased pitch relative to the previously developed resist image. | 11-27-2008 |
Eunah Chung, Cambridge, MA US
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20090215876 | Mitotic Progression Genes and Methods of Modulating Mitosis - The invention features methods of identifying candidate therapeutic compounds for the treatment of proliferative disorder. The invention also features methods for treating a proliferative disorder. | 08-27-2009 |
Hyung Won Chung, Cambridge, MA US
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20160074812 | Energy-Efficient Conductive-Gap Membrane Distillation - Apparatus for energy-efficient conductive-gap membrane distillation includes a feed-liquid source and a distillation module. The distillation module includes a feed-liquid chamber in fluid communication with the feed-liquid source. The feed-liquid chamber includes a selectively porous material that allows a component of the feed liquid to pass through the selectively porous material and exit the feed-liquid chamber in vapor form but not in liquid form. The distillation module also includes a conductive-gap chamber adjacent to the selectively porous material on an opposite side of the selectively porous material from the feed-liquid chamber; a heat-transfer surface maintained at a lower temperature than the feed liquid in the feed-liquid chamber, wherein the heat-transfer surface is in thermal contact with the conductive-gap chamber; and a thermally conductive material extending across the conductive-gap chamber. | 03-17-2016 |
Hyun Jung Chung, Cambridge, MA US
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20150125884 | Magnetic Labeling of Bacteria - The present invention provides novel methods of magnetically labeling a bacterial cell by contacting the call with an affinity ligand and subsequently contacting the cell with a magnetic agent, where the affinity ligand and magnetic agent include bioorthogonally reactive groups that can react with each other to form a covalent bond. Compounds, compositions, kits and applications of the method are also described. | 05-07-2015 |
Ivy Chung, Boston, MA US
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20120064008 | COMPOSITIONS FOR THE TREATMENT OF METASTATIC CANCER AND METHODS OF USE THEREOF - An in vivo assay for assessing the metastatic potential of cancer cells has been developed. This is a functional assay that also allows for screening of compounds that are selective for metastatic cancer. Metastatic cancer is established in animals by intravenous injection of metastatic cancer cells before treatments are tested. This assay has been used to identify benzimidazoles for the treatment of metastatic prostate cancers. The benzimidazole(s) can be formulated for enteral or parenteral administration. In one embodiment, the compositions are formulated for parenteral administration. Compositions containing a benzimidazole exhibit greater cytotoxicity against cell lines prone to metastasis than against cells lines that are less prone to metastasis in vitro. The benzimidazoles described herein were effective at treating metastatic prostate cancer in bone. Administration of benzimidazoles in metastatic prostate cancer mouse models showed a significant increase in the survival times of the animals, even against paclitaxel resistant cancer cell lines. | 03-15-2012 |
20140329879 | DIAGNOSIS AND TREATMENT OF TAXANE-RESISTANT CANCERS - Provided herein are methods and assays relating to the diagnosis and treatment of a taxane-resistant cancer. Such methods and assays comprise determining the level of expression of miR-135a in a biological sample from a subject having or suspected of having a taxane-resistant cancer or from a subject that was or is being treated with a taxane anti-cancer agent. Also provided herein are methods for treating such cancers by administering an inhibitor of the miR-135a pathway and a taxane to a subject in need thereof. | 11-06-2014 |
Jae Chung, Lexington, MA US
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20130212630 | Mobile Video Delivery - Methods and apparatus, including computer program products, for mobile video delivery. A method includes, in a mobile network comprising at least a core element and one or more evolved Node Bs (eNBs), receiving a request to initiate a progressive download of a video object, splitting the requested video object into self-contained independent video segments, transrating each of the self-contained independent video segments for different rates, and delivering a segment from a rate bucket that matches a current network condition determined by bandwidth estimation. | 08-15-2013 |
20130282868 | Integral Controller Based Pacing for HTTP Pseudo-streaming - Methods and apparatus, including computer program products, for integral controller based pacing for HTTP pseudo-streaming. A method includes receiving a request portions of a multimedia clip residing in the content server from a media player residing in the user equipment and delivering the requested portions of the multimedia clip to the media player while maintaining a target bitrate in a presence of control noises in the network. Delivering the requested portions of the multimedia clip can include estimating a target transmission rate, determining a target elasticity buffer, and estimating a number of bytes to send in a current transmission epoch. | 10-24-2013 |
Jae Won Chung, Lexington, MA US
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20140359052 | RESILIENT TCP SPLICING FOR PROXY SERVICES - A transparent proxy device includes an ingress, an egress, and an application proxy. The ingress and the egress operate up to a layer four communication layer. The transparent proxy device is configured to establish spliced connections in relation to end devices. The spliced connections include layer four connections between the ingress and the application proxy and the application proxy and the egress. The transparent proxy device is configured to maintain an end-to-end connection in relation to the end devices even when the application proxy fails. | 12-04-2014 |
20150118991 | Methods and Systems for Providing Subsidized Access to Network Content By Way of a Secure Connection - An exemplary method includes a subsidized access management system detecting a request provided by an access device associated with a user to access network content by way of a secure connection within a network provided by a network service provider, the network content associated with a content provider and maintained by a content provider system, determining that a data usage charge for access by the user to the network content by way of the secure connection within the network is subsidized by the content provider in accordance with a subsidized access arrangement between the content provider and the network service provider, and providing the user with subsidized access to the network content by way of the secure connection within the network in accordance with a rule set associated with the subsidized access arrangement. Corresponding methods and systems are also disclosed. | 04-30-2015 |
20150334248 | DEPLOYING A TOLL-FREE DATA SERVICE CAMPAIGN - A device may receive campaign information for deploying a toll-free data service campaign. The campaign information may identify a geographic region in which the toll-free data service campaign is to be deployed. The device may mark the toll-free data service campaign as ready to deploy, and may generate campaign rules based on the campaign information. The campaign rules may identify conditions for charging a content provider, associated with the toll-free data service campaign, for data used by a mobile device in association with the toll-free data service campaign. The device may deploy the toll-free data service campaign by providing the campaign rules to enforcement devices associated with the geographic region. The device may mark the toll-free data service campaign as being deployed. The device may determine that deployment of the toll-free data service campaign has been completed, and may mark the toll-free data service campaign as deployed. | 11-19-2015 |
20160086194 | METHOD, APPARATUS AND SYSTEM FOR PROVIDING A SECURE AND USER IDENTIFIABLE SERVICE SIGNATURE - An approach is provide for creating a secure and user-identifiable service signature. The approach involves creating a signature associated with a service, wherein the service is provided by a service provider to a user in conjunction with another party, and wherein the signature is personalized to the user. The approach also involves presenting the signature to the user via a device receiving a delivery, a link for initiating the delivery, or a combination thereof of the service to the user. | 03-24-2016 |
James Chung, Brookline, MA US
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20100263524 | Robot deployed weapon system and safing method - This subject invention features a robot deployed weapon system. A remotely controlled mobile robot has a weapon mounted to the robot. There is a firing circuit for the weapon and a weapon interrupt module on board the robot. An operator control unit is for remotely operating the robot and the weapon. The operating control unit preferably includes a stop switch. Also, a separate operator module is in communication with the weapon interrupt module. Preferably, the operator module includes a kill switch. There are two communication links. The first communication link is between the operator control unit and the robot. This communication link is configured to safe the weapon if the stop switch is activated and/or the first communication link degrades. The second communication link is between the operator module and the weapon interrupt module. The communication link is configured to safe the weapon if the kill switch is activated and/or the second communication link degrades. | 10-21-2010 |
Jinwook Chung, Cambridge, MA US
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20100032717 | DEVICES BASED ON SI/NITRIDE STRUCTURES - A nitride-based semiconductor device is provided. The nitride-base semiconductor device includes a substrate comprising one or more locally etched regions and a buffer layer comprising one or multiple InAlGaN layers on the substrate. A channel layer includes GaN on the buffer layer. A barrier layer includes one or multiple AlGaN layers on the channel layer. | 02-11-2010 |
20100301347 | WAFER BONDING TECHNIQUE IN NITRIDE SEMICONDUCTORS - A semiconductor arrangement is provided that includes one or more substrate structures. One or more nitride-based material structures are used in fabricating nitride-based devices. One or more intermediary layers are interposed between the one or more substrate structures and the one or more nitride-based material structures. The one or more intermediary layers support the lattice mismatch and thermal expansion coefficients between the one or more nitride-based material structure and the one or more substrate structures. Several new electronic devices based on this arrangement are described. | 12-02-2010 |
Joseph Taisup Chung, Cambridge, MA US
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20140279130 | SYSTEM AND METHOD FOR AN AFFINITY CAPTURE, USER FEEDBACK AND AFFINITY ANALYSIS - Various affinity systems and methods are provided to enable the capture of unique end-to-end purchase information. In some embodiments, the data collected through affinity systems and methods can be used to develop insights into the purchase making decision processes of users at any point of a shopping experience. The systems can host interaction platforms to facilitate the exchange of information, opinion, and/or suggestions on products, recommendations, and/or opinions. Further embodiments provide analysis of the captured data to derive insights regarding the appeal of products/services and the qualitative opinions of the users about the products/services. | 09-18-2014 |
20140279232 | SYSTEM AND METHOD FOR AN AFFINITY CAPTURE, USER FEEDBACK AND AFFINITY ANALYSIS - Various affinity systems and methods are provided to enable the capture of unique end-to-end purchase intent information. In some embodiments, the data collected through affinity systems and methods can be used to develop insights into the purchase making decision processes of users at any point of a shopping experience. The systems can host interaction platforms to facilitate the exchange of information, opinion, and/or suggestions on products, recommendations, and/or opinions. Further embodiments provide analysis of the captured data to derive insights regarding the appeal of products/services and the qualitative opinions of the users about the products/services. | 09-18-2014 |
20140279233 | SYSTEM AND METHOD FOR AN AFFINITY CAPTURE, USER FEEDBACK AND AFFINITY ANALYSIS - Provided in some embodiments is a social platform for soliciting qualified opinions and facilitating shopping, engaging shoppers, and delivering feedback. The social platform can communicate or integrate with existing sites to provide options for interacting with other qualified users. The platform can improve engagement, and increase social interaction. In some embodiments, affinity/feedback systems are provided that generate feedback for shoppers during their shopping experience. In addition to providing real-time feedback and opinions to shoppers, affinity and feedback systems can be configured to analyze and stored information on a complete purchasing experience. The complete purchasing experience can include, for example, initial identification of interest (e.g., establishing a purchase intent), specification of a product or service detail, actual identification and/or comparison of products/services, any interaction between shopping participants, conversations between participants, actual service/product purchase, and can also include after purchase conversation and/or review. | 09-18-2014 |
Kenny Chung, Hyde Park, MA US
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20100315267 | Touch Sensor System with Memory - A touch sensor system. The touch sensor system may include a touch sensor configured to provide an output in response to contact with a touch area, a controller coupled to the touch sensor and configured to provide a code representative of the output and a memory coupled to the controller. The memory may be configured to receive and store the code in a first time interval and to provide the code in a second time interval wherein the second time interval begins after the first time interval ends. Adjacent key suppression algorithms are also provided. | 12-16-2010 |
Kwanghun Chung, Cambridge, MA US
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20150285765 | ACTIVE TRANSPORT OF CHARGED MOLECULES INTO, WITHIN, AND/OR FROM CHARGED MATRICES - Articles and methods for the active transport of molecules into, within, and/or from a matrix are generally described. In some embodiments, an electric field may be used to alter the position of the molecule with respect to the matrix. The electric field may be used to move the molecule to a new location within the matrix, remove the molecule from the matrix, or infuse the molecule into the matrix. For instance, the electric field may be used to move a molecule having a binding partner within the matrix into or away from the vicinity of the binding partner. In some embodiments, the position of the molecule may be altered by exposing the molecule to an electrodynamic field. In some such embodiments, the molecule exposed to the dynamic electric field may have enhanced mobility and minimal adverse matrix interactions relative to conventional molecular transport methods, and in some cases, a molecule exposed to an electrostatic field. The active transport methods and articles, described herein, may be particularly well-suited for a variety of applications including histological, biological, and pharmaceutical applications. | 10-08-2015 |
Raymond T. Chung, Chestnut Hill, MA US
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20080260736 | Methods and Compositions to Regulate Iron Metabolism - The present invention provides new systems and strategies for the regulation of iron metabolism in mammals. In particular, methods of using agonists and antagonists of TGF-β superfamily members to modulate the expression or activity of hepcidin, a key regulator of iron metabolism, are described. The inventive methods find applications in the treatment of diseases associated with iron overload, such as juvenile hemochromatosis and adult hemochromatosis, and in the treatment of diseases associated with iron deficiency, such as anemia of chronic disease and EPO resistant anemia in end-stage of renal disease. The present invention also relates to screening tools and methods for the development of novel drugs and therapies for treating iron metabolism disorders. | 10-23-2008 |
20110312985 | NARINGENIN COMPLEXES AND METHODS OF USE THEREOF - The invention relates to methods of treatment of hepatitis C, dyslipidemia, insulin resistance, and inflammation, with flavonoid-sugar complexes. | 12-22-2011 |
20120009601 | METHODS AND COMPOSITIONS FOR REPROGRAMMING CELLS - The present invention is directed, in part, to methods and compositions comprising inhibitors of micro RNA-145 and activators of the TGF-β signaling pathway to permit reprogramming using only small molecule compounds. Also described herein are methods to distinguish cancer cells or cells having cancerous potential in human iPS cell populations, based on determining the balance of p21-p53 expression levels, or ratio thereof in reprogrammed cells. In further aspects, methods and compositions to cause redifferentiation of a hepatoma cell to a hepatocye-like cell using acyclic retinoid and inhibitors of AKR1B10 are provided. | 01-12-2012 |
20120064076 | METHODS AND COMPOSITION TO REGULATE IRON METABOLISM - The present invention provides new systems and strategies for the regulation of iron metabolism in mammals. In particular methods of using agonists and antagonists of TGF-β superfamily members to modulate the expression or activity of hepcidin, a key regulator of iron metabolism, are described. The inventive methods find applications in the treatment of diseases associated with iron overload, such as juvenile hemochromatosis and adult hemochromatosis, and in the treatment of diseases associated with iron deficiency, such as anemia of chronic disease and EPO resistant anemia in end-stage of renal disease. The present invention also relates to screening tools and methods for the development of novel drugs and therapies for treating iron metabolism disorders. | 03-15-2012 |
20120094939 | ANTI-VIRAL COMPOUNDS, COMPOSITIONS AND METHODS - The present invention is directed to compounds of formulae (I) and (II) and pharmaceutically acceptable forms thereof; pharmaceutical compositions thereof; and methods of treating a viral infection, such as a hepatitis C virus (HCV) infection, by administering to a subject diagnosed with or being susceptible to the viral infection a compound of formulae (I) and (II), a pharmaceutically acceptable form thereof, or a pharmaceutical composition thereof. The present invention is also directed to high-throughput methods of identifying compounds able to modulate hepatitis C virus (HCV) replication activity. | 04-19-2012 |
20120258105 | METHODS AND COMPOSITIONS TO REGULATE IRON METABOLISM - The present invention provides new systems and strategies for the regulation of iron metabolism in mammals. In particular, methods of using agonists and antagonists of TGF-β superfamily members to modulate the expression or activity of hepcidin, a key regulator of iron metabolism, are described. The inventive methods find applications in the treatment of diseases associated with iron overload, such as juvenile hemochromatosis and adult hemochromatosis, and in the treatment of diseases associated with iron deficiency, such as anemia of chronic disease and EPO resistant anemia in end-stage of renal disease. The present invention also relates to screening tools and methods for the development of novel drugs and therapies for treating iron metabolism disorders. | 10-11-2012 |
20130149304 | USE OF MODULATORS OF COMPOUNDS OF TGF-BETA SUPERFAMILY TO REGULATE HEPCIDIN-MEDIATED IRON METABOLISM - The present invention provides new systems and strategies for the regulation of iron metabolism in mammals. In particular, methods of using agonists and antagonists of TGF-β superfamily members to modulate the expression or activity of hepcidin, a key regulator of iron metabolism, are described. The inventive methods find applications in the treatment of diseases associated with iron overload, such as juvenile hemochromatosis and adult hemochromatosis, and in the treatment of diseases associated with iron deficiency, such as anemia of chronic disease and EPO resistant anemia in end-stage of renal disease. The present invention also relates to screening tools and methods for the development of novel drugs and therapies for treating iron metabolism disorders. | 06-13-2013 |
20150072927 | METHODS AND COMPOSITIONS TO REGULATE HEPCIDIN EXPRESSION - The present invention provides new systems and strategies for the regulation of iron metabolism in mammals. In particular, methods of using agonists and antagonists of TGF-β superfamily members to modulate the expression or activity of hepcidin, a key regulator of iron metabolism, are described. The inventive methods find applications in the treatment of diseases associated with iron overload, such as juvenile hemochromatosis and adult hemochromatosis, and in the treatment of diseases associated with iron deficiency, such as anemia of chronic disease and EPO resistant anemia in end-stage of renal disease. The present invention also relates to screening tools and methods for the development of novel drugs and therapies for treating iron metabolism disorders. | 03-12-2015 |
Sangmi Chung, Belmont, MA US
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20130052268 | COMPOSITIONS AND METHODS FOR TREATMENT OF PARKINSON'S DISEASE - The present invention relates to methods for producing neural cells from progenitor or stem cells by activating both the Wnt1-Lmx1a/Lmx1b and the SHH-FoxA2 signaling pathways by, for example, increasing the biological activity of one or more of Wnt1, Lmx1a, Lmx1b, Otx2 and Pitx3 and one or more of SHH, FoxA2 and Nurr1 in the progenitor or stem cells including embryonic stem cells and iPS cells. Such cells may be used for the treatment of Parkinson's disease. The invention further relates to methods for treating Parkinson's disease by increasing the biological activity of one or more of Wnt1, Lmx1b, Lmx1b, Otx2 and Pitx3 and one or more of SHH, FoxA2 and Nurr1 in the midbrain of a patient. In particular, the biological activity of the proteins can be increased by virtue of a cell penetrating peptide fused to the proteins or by transfecting RNAs encoding the proteins such that the host chromosomal DNAs remain intact. | 02-28-2013 |
Sangmi Chung, Lexington, MA US
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20140199274 | NEURONAL PROGENITOR CELLS AND USES - Provided are methods of isolating a novel cell population of midbrain dopaminergic neuronal progenitor cells derived from stem cells using a novel combination markers. The cell population may be used for cell therapies for the treatment of Parkinson's disease and as substrates in pharmacological assays. | 07-17-2014 |
Seok Chung, Somerville, MA US
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20110159522 | Three-Dimensional Microfluidic Platforms and Methods of Use Thereof - Provided are methods and devices for formation and study of three-dimensional biological systems, including prokaryotic and eukaryotic cell migration, proliferation, and differentiation. | 06-30-2011 |
Seok Chung, Cambridge, MA US
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20110027873 | MICRO-NANO FLUIDIC BIOCHIP FOR ASSAYING BIOLOGICAL SAMPLE - Disclosed is a micro-nano fluidic biochip for assaying a biological sample comprising a first substrate, a second substrate and a third substrate which are sequentially stacked from bottom to top, wherein an upper channel assembly disposed on the second substrate is coupled with the lower channel assembly provided on the first substrate, to form a microfluidic channel, and the microfluidic channel has nano interstices formed at both sides thereof, the nano interstices having a height less than that of the center of the channel. | 02-03-2011 |
20110033338 | MICROFLUIDIC CIRCUIT ELEMENT COMPRISING MICROFLUIDIC CHANNEL WITH NANO INTERSTICES AND FABRICATION METHOD THEREOF - A microfluidic circuit element comprising a microfluidic channel, in which the microfluidic channel has nano interstices formed at both sides thereof and having a height less than that of the center of the channel, gives more driving force of the microfluidic channel and provides stable flow of a fluid. | 02-10-2011 |
20160038941 | MICROFLUIDIC CIRCUIT ELEMENT COMPRISING MICROFLUIDIC CHANNEL WITH NANO INTERSTICES AND FABRICATION METHOD THEREOF - A microfluidic circuit element comprising a microfluidic main channel and nano interstices is disclosed. The nano interstices are formed at both sides of the main channel and are in fluid communication with the main channel. The nano interstices have a height less than that of the main channel, gives more driving force of the microfluidic channel and provides stable flow of a fluid. The microfluidic circuit element may be made from a plastic material having a contact angle of 90 degrees or less. The microfluidic circuit element is particularly useful when filling a liquid sample to the channel which is empty or filled with air and shows greatly improved a storage stability. | 02-11-2016 |
Sungwon Chung, Cambridge, MA US
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20100117727 | ASYMMETRIC MULTILEVEL OUTPHASING ARCHITECTURE FOR RF AMPLIFIERS - A radio frequency (RF) circuit includes a power supply configured to generate a plurality of voltages, a plurality of power amplifiers, each having an RF output port and a power supply input port, a switch network having a plurality of input ports coupled to the power supply and a plurality of switch network output ports coupled to the power supply input ports of the plurality of power amplifiers, wherein the switch network is configured to output selected ones of the plurality of voltages from the plurality of switch network output ports, at least two of the switch network output port voltages capable of being different ones of the plurality of voltages, and an RF power combiner circuit having a plurality of input ports coupled to RF output ports of the plurality of power amplifiers and an output port at which is provided an output signal of the RF circuit. | 05-13-2010 |
20110215866 | ASYMMETRIC MULTILEVEL OUTPHASING ARCHITECTURE FOR RF AMPLIFIERS - A radio frequency (RF) circuit includes a power supply configured to generate a plurality of voltages, a plurality of power amplifiers, each having an RF output port and a power supply input port, a switch network having a plurality of input ports coupled to the power supply and a plurality of switch network output ports coupled to the power supply input ports of the plurality of power amplifiers, wherein the switch network is configured to output selected ones of the plurality of voltages from the plurality of switch network output ports, at least two of the switch network output port voltages capable of being different ones of the plurality of voltages, and an RF power combiner circuit having a plurality of input ports coupled to RF output ports of the plurality of power amplifiers and an output port at which is provided an output signal of the RF circuit. | 09-08-2011 |
20120176195 | Asymmetric Multilevel Outphasing Architecture For RF Amplifiers - A radio frequency (RF) circuit includes a power supply configured to generate a plurality of voltages, a plurality of power amplifiers, each having an RF output port and a power supply input port, a switch network having a plurality of input ports coupled to the power supply and a plurality of switch network output ports coupled to the power supply input ports of the plurality of power amplifiers, wherein the switch network is configured to output selected ones of the plurality of voltages from the plurality of switch network output ports, at least two of the switch network output port voltages capable of being different ones of the plurality of voltages, and an RF power combiner circuit having a plurality of input ports coupled to RF output ports of the plurality of power amplifiers and an output port at which is provided an output signal of the RF circuit. | 07-12-2012 |
20140125412 | Asymmetric Multilevel Outphasing Architecture For RF Amplifiers - A radio frequency (RF) circuit includes a power supply configured to generate a plurality of voltages, a plurality of power amplifiers, each having an RF output port and a power supply input port, a switch network having a plurality of input ports coupled to the power supply and a plurality of switch network output ports coupled to the power supply input ports of the plurality of power amplifiers, wherein the switch network is configured to output selected ones of the plurality of voltages from the plurality of switch network output ports, at least two of the switch network output port voltages capable of being different ones of the plurality of voltages, and an RF power combiner circuit having a plurality of input ports coupled to RF output ports of the plurality of power amplifiers and an output port at which is provided an output signal of the RF circuit. | 05-08-2014 |
Sungwon Chung, Brookline, MA US
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20150357989 | Output Matching Network for Wideband Power Amplifier with Harmonic Suppression - A wideband harmonic trap includes a first resonant tank in the form of a parallel LC circuit, and a second resonant tank in the form of a series LC circuit. The LC circuits are connected to it common input, an output of the parallel LC circuit is connected to a load and to ground via a shunt capacitor, and an output of the series LC circuit is connected to the ground. | 12-10-2015 |
20160087585 | Wideband Self-Envelope Tracking RF Power Amplifier - A wideband self-envelope tracking power amplifier (PA) can use more than a 40-MHz channel bandwidth and improves the envelope bandwidth limit of a self-envelope tracking PAs by ten times. The PA uses an envelope load network, which is based on a general multi-stage low-pass filter. The envelope load network located between an RF choke inductor and main DC power supply provides a dynamically modulated PA supply voltage without using a dedicated envelope amplifier. An input terminal of the network connects a main PA via an RF choke inductor to an input of low-pass filter. An output terminal is connected to the low-pass filter via an envelope choke inductor and to a direct current (DC) power supply. A DC blocker is connected between the output of the low-pass filter and ground by a termination resistor. | 03-24-2016 |
Wen-Li Chung, Arlington, MA US
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20100239531 | STABLE LIQUID INTERFERON FORMULATIONS - Liquid interferon compositions having a pH between 4.0 and 7.2 are described. The compositions comprise interferon-beta and a stabilizing agent at between about 0.3% and 5% by weight which is an amino acid selected from the group consisting of acidic amino acids, arginine and glycine. If needed, salt is added to provide sufficient ionic strength. The liquid composition has not been previously lyophilized or previously cavitated. The liquid is preferably contained within a vessel having at least one surface in contract with the liquid that is coated with a material inert to adsorption of interferon-beta. A kit for parenteral administration of a liquid interferon formulation and a method for stabilizing liquid interferon compositions are also described. | 09-23-2010 |
20130302281 | STABLE LIQUID INTERFERON FORMULATIONS - Liquid interferon compositions having a pH between 4.0 and 7.2 are described. The compositions comprise interferon-beta and a stabilizing agent at between about 0.3% and 5% by weight which is an amino acid selected from the group consisting of acidic amino acids, arginine and glycine. If needed, salt is added to provide sufficient ionic strength. The liquid composition has not been previously lyophilized or previously cavitated. The liquid is preferably contained within a vessel having at least one surface in contract with the liquid that is coated with a material inert to adsorption of interferon-beta. A kit for parenteral administration of a liquid interferon formulation and a method for stabilizing liquid interferon compositions are also described. | 11-14-2013 |
Young Chung, Shrewsbury, MA US
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20100240132 | HIGHLY EFFICIENT METHODS FOR REPROGRAMMING DIFFERENTIATED CELLS AND FOR GENERATING ANIMALS AND EMBRYONIC STEM CELLS FROM REPROGRAMMED CELLS - The present invention relates generally to the field of somatic cell nuclear transfer (SCNT) and to the creation of cloned animals and cells. The disclosure relates to a method of cloning a mammal, obtaining pluripotent cells such as embryonic stem cells, or for reprogramming a mammalian cell using an oocyte and a fertilized embryo. | 09-23-2010 |
20110150842 | Derivation of Embryonic Stem Cells - This present invention provides novel methods for deriving embryonic stem cells, those cells and cell lines, and the use of the cells for therapeutic and research purposes without the destruction of the embryo. It also relates to novel methods of establishing and storing an autologous stem cell line prior to implantation of an embryo, e.g., in conjunction with reproductive therapies such as IVF. | 06-23-2011 |
Young Gie Chung, Shrewsbury, MA US
Patent application number | Description | Published |
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20110183415 | DERIVATION OF EMBRYONIC STEM CELLS AND EMBRYO-DERIVED CELLS - This present invention provides novel methods for deriving embryonic stem cells and embryo-derived cells from an embryo without requiring destruction of the embryo. The invention further provides cells and cell lines derived without embryo destruction, and the use of the cells for therapeutic and research purposes. It also relates to novel methods of establishing and storing an autologous stem cell line prior to implantation of an embryo, e.g., in conjunction with reproductive therapies such as IVF. | 07-28-2011 |
20140234968 | PRODUCTION OF PARTHENOGENETIC STEM CELLS AND PATIENT-SPECIFIC HUMAN EMBRYONIC STEM CELLS USING SOMATIC CELL NUCLEAR TRANSFER - Immunocompatible pluripotent stem cells (pSCs), which include cells compatible with different patient populations or patient-specific cells, find wide application in regenerative medicine therapies. Described herein are immunocompatible pSCs generated using techniques such as parthenogenesis resulting in cells possessing desired haplotypes of reduced zygosity, antigenically compatible with multiple patient populations, or nuclear transfer allowing generation of patient-specific cells. Methods described herein related to parthenogenesis, nuclear transfer, or pSC cell line generation. Also described herein are compositions of immunocompatible pSCs and cell lines generated by the aforementioned techniques. | 08-21-2014 |
20140356952 | DERIVATION OF EMBRYONIC STEM CELLS AND EMBRYO-DERIVED CELLS - This present invention provides novel methods for deriving embryonic stem cells and embryo-derived cells from an embryo without requiring destruction of the embryo. The invention further provides cells and cell lines derived without embryo destruction, and the use of the cells for therapeutic and research purposes. It also relates to novel methods of establishing and storing an autologous stem cell line prior to implantation of an embryo, e.g., in conjunction with reproductive therapies such as IVF. | 12-04-2014 |
20140377865 | DERIVATION OF EMBRYONIC STEM CELLS - This present invention provides novel methods for deriving embryonic stem cells, those cells and cell lines, and the use of the cells for therapeutic and research purposes without the destruction of the embryo. It also relates to novel methods of establishing and storing an autologous stem cell line prior to implantation of an embryo, e.g., in conjunction with reproductive therapies such as IVF. | 12-25-2014 |
20150175960 | HIGHLY EFFICIENT METHODS FOR REPROGRAMMING DIFFERENTIATED CELLS AND FOR GENERATING ANIMALS AND EMBRYONIC STEM CELLS FROM REPROGRAMMED CELLS - The present invention relates generally to the field of somatic cell nuclear transfer (SCNT) and to the creation of cloned animals and cells. The disclosure relates to a method of cloning a mammal, obtaining pluripotent cells such as embryonic stem cells, or for reprogramming a mammalian cell using an oocyte and a fertilized embryo. | 06-25-2015 |