Noordman
Maarten Noordman, Erichem NL
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20130145599 | ASSEMBLY COMPRISING A RADIALLY INTERMEDIATE JOINT AND CORRESPONDING METHOD OF JOINING TWO COMPONENTS - An assembly comprising a first component joined to a second component by means of an intermediate joint is provided. The first component has a first joining surface arranged coaxially and spaced in a juxtaposition around a second joining surface of the second component, such that a groove is defined between the first and second joining surfaces. The groove comprises an arcuate section formed in that one of the first and second joining surfaces comprises a concave portion and the other of the first and second joining surfaces comprises a convex portion, radially opposite from the concave portion. The intermediate joint is formed by an insert ring, made of a high strength material, pressed into the groove and deformed such that material of the insert ring fills the concave portion and surrounds the convex portion. Consequently, the first and second components are locked relative to each other in both axial directions. | 06-13-2013 |
Martines Maria Josef Noordman, Erichem NL
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20150024129 | PROCESS FOR PREPARING A PROTECTIVE LAYER ON A TRIBOLOGICAL SURFACE OF A MECHANICAL COMPONENT - The invention provides a process for preparing a protective layer on a tribological surface of a mechanical component, wherein the layer comprises a metal phosphate and/or metal sulphate having anti-wear and/or anti-fretting properties, and the process comprises subjecting the tribological surface of the component to a mechanical treatment which is carried out with a tool that moves at or along the tribological surface during which treatment the metal phosphate and/or metal sulphate in solid form is provided and the layer is formed on the surface of the mechanical component by means of deposition of the metal phosphate and/or metal sulphate compound. | 01-22-2015 |
Oscar Franciscue Jozephus Noordman, Eindhoven NL
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20100163757 | Pulse Modifier with Adjustable Etendue - A beam modifying unit increases both temporal pulse length and Etendue of an illumination beam. The pulse modifying unit receives an input pulse of radiation and emits one or more corresponding output pulses of radiation. A beam splitter divides the incoming pulse into a first and a second pulse portion, and directs the first pulse portion along a second optical path and the second portion along a first optical path as a portion of an output beam. The second optical path includes a divergence optical element. A first and a second mirror, each with a radius of curvature, are disposed facing each other with a predetermined separation, and receive the second pulse portion to redirect the second portion, such that the optical path of the second portion through the pulse modifier is longer than that of the first portion, and the separation is less than radius of curvature. | 07-01-2010 |
Oscar Franciscus Jozephus Noordman, Eindhoven NL
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20090201483 | Polarization Control Apparatus and Method - Apparatus and methods are used to control a polarization state of a radiation beam. A polarization control unit is configured to modulate a polarization state of at least a part of a radiation beam. A determination arrangement is configured to subsequently determine the polarization state of the at least a part of the radiation beam. A feedback unit is configured to provide signals to the polarization control arrangement based on at least the determined polarization state in order to correct for deviation in the polarization state of the part of the radiation beam from a desired polarization state. For example, the correction may ensure that the polarization state of the part of the radiation beam is at, or returns to, the desired polarization state. | 08-13-2009 |
20110255173 | Pulse Modifier with Adjustable Etendue - A beam modifying unit increases both temporal pulse length and Etendue of an illumination beam. The pulse modifying unit receives an input pulse of radiation and emits one or more corresponding output pulses of radiation. A beam splitter divides the incoming pulse into a first and a second pulse portion, and directs the first pulse portion along a second optical path and the second portion along a first optical path as a portion of an output beam. The second optical path includes a divergence optical element. A first and a second mirror, each with a radius of curvature, are disposed facing each other with a predetermined separation, and receive the second pulse portion to redirect the second portion, such that the optical path of the second portion through the pulse modifier is longer than that of the first portion, and the separation is less than radius of curvature. | 10-20-2011 |
Tom Reinoud Noordman, Oegstgeest NL
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20130183402 | METHOD AND APPARATUS FOR THE RECOVERY OF PVPP AFTER CONTACT WITH A YEAST FERMENTED BEVERAGE BY SEDIMENTATION SEPARATION - A method of preparing a yeast fermented beverage is provided, which method comprises (a) fermenting wort with a biologically active yeast to produce a fermented liquid; (b) combining the fermented liquid with polyvinylpolypyrrolidone (PVPP) particles to bind at least a fraction of the polyphenols and/or proteins contained in the fermented liquid; (c) removing a slurry containing the PVPP particles and yeast from the fermented liquid; (d) separating said slurry into a yeast-enriched fraction and a PVPP-enriched fraction a technique selected from flotation separation, settling separation and separation using a hydrocyclone; (e) regenerating the PVPP particles before, during and/or after the separation by desorbing polyphenols and/or protein from said PVPP-particles; and (f) recirculating the regenerated PVPP particles to step (b). The method can be operated with single use PVPP as well as regenerable PVPP and does not require sophisticated filter hardware for regenerating the PVPP. | 07-18-2013 |
20130183403 | METHOD OF STABILISING YEAST FERMENTED BEVERAGES - A method of preparing yeast fermented beverage is provided, comprising (a) fermenting wort with yeast to produce a fermented liquid containing yeast, alcohol, polyphenols and protein; (b) optionally removing the yeast; (c) combining the fermented liquid with polyvinylpolypyrrolidone (PVPP) particles to bind at least a fraction of the polyphenols and/or proteins, wherein at least 80 wt. % of the PVPP particles have a diameter of 5-300 μm; (d) removing a slurry containing the PVPP particles; (e) filtering the slurry over a filter having a pore size of 0.1-80 μm to produce a PVPP-enriched retentate and a PVPP-depleted filtrate; (f) regenerating the PVPP particles in the PVPP-enriched retentate by desorbing and separating the polyphenols and/or protein from the PVPP-particles; and (f) optionally, further refining and recirculating the regenerated PVPP particles to step (c). The method can be operated with single use PVPP or regenerable PVPP and does not require capacious filter hardware. | 07-18-2013 |
20130196025 | METHOD FOR THE REGENERATION OF PVPP FROM A MEMBRANE FILTER RETENTATE AFTER CLARIFICATION AND STABILIZATION OF A YEAST FERMENTED BEVERAGE - A method of preparing a yeast fermented beverage is disclosed, comprising: (a) fermenting wort with yeast to produce a fermented liquid; (b) optionally removing the yeast; (c) mixing the fermented liquid with polyvinylpolypyrrolidone (PVPP) particles; (d) filtering the fermented liquid over a first membrane filter without employing a filter aid; (e) combining a first retentate with an aqueous regeneration liquid to desorb polyphenols and/or protein from the PVPP particles, wherein the aqueous regeneration liquid has a pH of at least 10.0; (f) filtering the combination retentate and regeneration liquid over a second membrane filter without employing a filter aid; and (g) after, optional further refining the regenerated PVPP particles from the second retentate, and recirculating the particles to step (c); wherein macromolecular components contained in the first retentate and/or retained on the second filter are degraded using a degradative agent selected from oxidants, enzymes and combinations thereof. | 08-01-2013 |
Wouter Noordman, Ede NL
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20100203026 | PROBIOTICS FOR INDUCING SATIETY AND/OR SATIATION - The invention relates to the field of nutrition and medicine. Provided are compositions, bacterial strains and methods for inducing or enhancing satiety and satiation and for treating or preventing obesity, overweight and overweight related diseases. | 08-12-2010 |
Yvet Noordman, Amsterdam NL
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20130023034 | MUTATED REP ENCODING SEQUENCES FOR USE IN AAV PRODUCTION - The invention relates to a nucleic acid comprising a nucleotide sequence encoding a Parvoviral Rep protein, wherein a nuclear localization signal (NLS) in said Parvoviral Rep protein is mutated as compared with a corresponding wild type sequence. The invention also relates to a nucleic acid comprising a nucleotide sequence encoding a Parvoviral Rep protein, wherein the zinc finger domain in said Parvoviral Rep protein is mutated as compared with a corresponding wild type sequence. Further, the invention relates to a nucleic acid comprising a nucleotide sequence encoding a Parvoviral Rep protein, wherein an amino acid at position 43, 57, 79, 97, 120, 179, 305, 484, 493 or 571 of the said Parvoviral Rep protein is mutated in comparison to a corresponding wild type sequence, said amino acid position being defined with reference to SEQ ID NO: 2. | 01-24-2013 |
Yvet Noordman, Ultrecht NL
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20110136227 | OPTIMISATION OF EXPRESSION OF PARVOVIRAL REP AND CAP PROTEINS IN INSECT CELLS - The present invention relates to the improved production of recombinant parvoviral virions in insect cells. In particular, the invention relates to an improved process for the production of recombinant parvoviral virions in insect cells, wherein the full/empty parvoviral virion ratio is increased. The invention also relates to the production of parvoviral vectors that may be used in gene therapy and to improvements in expression of the viral Rep proteins that increase the productivity of parvoviral vectors. | 06-09-2011 |
Yvet Noordman, Utrecht NL
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20110119777 | USE OF AAV REPLICATION MACHINERY FOR IMPROVED PROTEIN PRODUCTION - The present invention provides a method for enhanced production of a gene product of interest in a cell, using the AAV replication machinery. The present invention further relates to a cell for use in the method of the invention and a non-human transgenic animal or a transgenic plant comprising a cell of the invention. | 05-19-2011 |
20140127801 | OPTIMIZATION OF EXPRESSION OF PARVOVIRAL REP AND CAP PROTEINS IN INSECT CELLS - The present invention relates to the improved production of recombinant parvoviral virions in insect cells. In particular, the invention relates to an improved process for the production of recombinant parvoviral virions in insect cells, wherein the full/empty parvoviral virion ratio is increased. The invention also relates to the production of parvoviral vectors that may be used in gene therapy and to improvements in expression of the viral Rep proteins that increase the productivity of parvoviral vectors. | 05-08-2014 |