Gardner, MA
Alan T. Gardner, E. Falmouth, MA US
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20100198547 | DIFFERENTIAL PRESSURE SYSTEMS AND METHODS FOR MEASURING HYDRAULIC PARAMETERS ACROSS SURFACE WATER-AQUIFER INTERFACES - The systems and methods described herein related to measuring hydraulic parameters across a surface water-aquifer interface. In particular, the systems include a pressure differential sensor within a watertight housing. The pressure differential sensor has two inlets, one of which is connected to a piezometer located in an aquifer, and the other of which is connected to a surface water body. A solenoid valve allows the systems to switch between a first, measurement configuration and a second, calibration configuration. A pump and a conductivity-temperature sensor enable a third and fourth configuration for measuring the electrical conductivity and temperature of surface water and groundwater. The collected data is then locally stored or transmitted wirelessly. The low-power components and calibration capabilities of the systems allow for long-term deployment, on the order of six months or more. | 08-05-2010 |
Andrew Gardner, Manchester, MA US
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20110045489 | Polymerases for Incorporating Modified Nucleotides - Compositions and methods are provided that relate to a recombinant protein with DNA polymerase activity in which one or more amino acids are mutated compared with the corresponding wild type protein. The recombinant protein is capable of incorporating one or more modified nucleotides into a nucleic acid substrate with a specific activity greater than 200. | 02-24-2011 |
20130196327 | DNA Polymerase Variants with Reduced Exonuclease Activity and Uses Thereof - Compositions and methods are described to modify Family B DNA polymerases that contain residual exonuclease activity that interferes with sequencing techniques and with detection of single nucleotide polymorphisms. The compositions are mutant proteins with reduced exonuclease activity compared with presently available “exo | 08-01-2013 |
20140296082 | DNA Polymerase Variants with Reduced Exonuclease Activity and Uses Thereof - Compositions and methods are described to modify Family B DNA polymerases that contain residual exonuclease activity that interferes with sequencing techniques and with detection of single nucleotide polymorphisms. The compositions are mutant proteins with reduced exonuclease activity compared with presently available “exo | 10-02-2014 |
Colin R. Gardner, Concord, MA US
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20100210027 | METHOD FOR DETERMINING EFFECT OF PREFORMULATION FORMS ON THEIR DISSOLUTION RATES - Preformulation analysis and optimization comprising dissolution strudies. | 08-19-2010 |
20130323179 | NANOCRYSTALS, COMPOSITIONS, AND METHODS THAT AID PARTICLE TRANSPORT IN MUCUS - Nanocrystals, compositions, and methods that aid particle transport in mucus are provided. In some embodiments, the compositions and methods involve making mucus-penetrating particles (MPP) without any polymeric carriers, or with minimal use of polymeric carriers. The compositions and methods may include, in some embodiments, modifying the surface coatings of particles formed of pharmaceutical agents that have a low water solubility. Such methods and compositions can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for administration routes involving the particles passing through a mucosal barrier. | 12-05-2013 |
Craig M. Gardner, Belmont, MA US
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20130197815 | MANAGEMENT OF REFERENCE SPECTRAL INFORMATION AND SEARCHING - A processing application receives peak information associated with multiple known references samples. The processing application partitions a spectrum into multiple different sized range bins such that a substantially equal number of the peaks associated with the known reference samples reside into each of the multiple different sized range bins. To identify a set of candidate reference samples in a library of reference samples that potentially are a good match an unknown sample under test, the processing application compares peaks associated with the unknown sample to the multiple different sized range bins. The greater the number of range bin matches based on peaks in the unknown sample and peaks in a corresponding reference sample, the greater the likelihood that the unknown sample matches the corresponding reference sample. | 08-01-2013 |
20140005980 | METHOD FOR TAGGING REFERENCE MATERIALS OF INTEREST IN SPECTROSCOPIC SEARCHING APPLICATIONS | 01-02-2014 |
Craig Morris Gardner, Belmont, MA US
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20130016337 | HEROIN DETECTION BY RAMAN SPECTROSCOPY FROM IMPURE COMPOSITIONS COMPRISING AN INTERFERING FLUORESCENT CONTAMINANT - A method of identifying the presence of heroin in an impure heroin composition which contains heroin and at least one fluorescent contaminant which interferes with a Raman signal from the heroin. The method may include contacting the mixture with a solvent such as an alcohol, then contacting the resulting alcohol composition with a SERS surface. The surface may then be exposed to laser light from a hand-held Raman spectrometer to detect a Raman signal from the heroin. An apparatus for performing the method is also provided. | 01-17-2013 |
David A. Gardner, Sudbury, MA US
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20120175683 | Basic Cell Architecture For Structured ASICs - A basic cell circuit architecture having plurality of cells with fixed transistors configurable for the formation of logic devices and single and dual port memory devices within a structured ASIC is provided. Different configurations of ensuing integrated circuits are achieved by forming variable interconnect layers above the fixed structures. The circuit architecture can achieve interconnection of transistors within a single cell or across multiple cells. The interconnection can be configured to form basic logic gates as well as more complex digital and analog subsystems. In addition, each cell contains a layout of transistors that can be variably coupled to achieve a memory device, such as a SRAM device. By having the capability of forming a logic circuit element, a memory device, or both, the circuit architecture is both memory-centric and logic-centric, and more fully adaptable to modern-day SoCs. | 07-12-2012 |
Graham Gardner, Sudbury, MA US
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20120310943 | METHOD AND APPARATUS FOR CONDUCTING AN INFORMATION BROKERING SERVICE - A system and method is provided that provides an early indication of consensus of opinion among a number of users regarding an event or observation indicated by a user. Such an opinion may be interesting to an information consumer, who may be interested in determining the outcome of the consensus relating to the event or observation, or may otherwise desire to perform surveillance or survey of a particular issue or subject. Such recognition of early events or observations may be useful in different areas, such as healthcare, finance, etc., where initial observations, if provided early, allow resulting decisions to be made much earlier. The opinion may, for instance, be used as an early indicator of problem with a product, company, etc. that would permit an information consumer to perform an action at a much earlier point than if he/she relied on traditional sources of information. Opinion information may be invaluable as a tool for monitoring events. | 12-06-2012 |
20140052569 | Methods and Systems for Matching a Professional with a Referral Opportunity - A method for matching a professional with a referral opportunity includes automatically generating, by a profile generator executing on a first computing device, a profile of a professional. The method includes receiving, by an analysis engine executing on the first computing device, from a second computing device, an identification of a referral opportunity having at least one requirement. The method includes determining, by the analysis engine, that the generated profile satisfies the at least one requirement. The method includes transmitting, by the analysis engine, to the second computing device, the identification of the professional. | 02-20-2014 |
Graham Gardner, Cambridge, MA US
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20120150664 | Method and apparatus for conducting an information brokering service - A system and method is provided that provides an early indication of consensus of opinion among a number of users regarding an event or observation indicated by a user. Such an opinion may be interesting to an information consumer, who may be interested in determining the outcome of the consensus relating to the event or observation, or may otherwise desire to perform surveillance or survey of a particular issue or subject. Such recognition of early events or observations may be useful in different areas, such as healthcare, finance, etc., where initial observations, if provided early, allow resulting decisions to be made much earlier. The opinion may, for instance, be used as an early indicator of problem with a product, company, etc. that would permit an information consumer to perform an action at a much earlier point than if he/she relied on traditional sources of information. Thus, such opinion information may be invaluable as a tool for monitoring events. | 06-14-2012 |
Graham S. Gardner, Sudbury, MA US
Patent application number | Description | Published |
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20140249888 | METHOD AND APPARATUS FOR CONDUCTING AN INFORMATION BROKERING SERVICE - A system and method is provided that provides an early indication of consensus of opinion among a number of users regarding an event or observation indicated by a user. Such an opinion may be interesting to an information consumer, who may be interested in determining the outcome of the consensus relating to the event or observation, or may otherwise desire to perform surveillance or survey of a particular issue or subject. Such recognition of early events or observations may be useful where initial observations, if provided early, allow resulting decisions to be made much earlier. The opinion may, for instance, be used as an early indicator of problem with a product, company, etc. that would permit an information consumer to perform an action at a much earlier point than if he/she relied on traditional sources of information. Thus, such opinion information may be invaluable as a tool for monitoring events. | 09-04-2014 |
Graham Stewart Gardner, Sudbury, MA US
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20130096991 | METHODS AND SYSTEMS FOR PROFILING PROFESSIONALS - A method for profiling entities or individuals includes automatically generating, by a profile generator executing on a first computing device, a profile of at least one of a professional and an entity. The method includes automatically analyzing, by an analysis engine executing on the first computing device, the generated profile. The method includes determining, by the analysis engine, responsive to the analysis, at least one of a level of expertise and a level of influence in an industry of the at least one of the professional and the entity. The method includes transmitting, by the analysis engine, to a second computing device, an identification of the determined level of expertise. In one embodiment, the method includes generating, by a prediction engine executing on the first computing device a prediction of a future modification to the profile. | 04-18-2013 |
20150134388 | METHODS AND SYSTEMS FOR PROVIDING, BY A REFERRAL MANAGEMENT SYSTEM, DYNAMIC SCHEDULING OF PROFILED PROFESSIONALS - A method for matching a professional with a referral opportunity includes automatically generating, by a profile generator executing on a first computing device, a profile of a professional. The method includes receiving, by an analysis engine executing on the first computing device, from a second computing device, an identification of a referral opportunity having at least one requirement. The method includes determining, by the analysis engine, that the generated profile satisfies the at least one requirement. The method includes transmitting, by the analysis engine, to the second computing device, the identification of the professional. The method includes receiving, by the first computing device, an indication that a user of the second computing device made a referral to the professional. The method includes scheduling, by a workflow engine executing on the first computing device, an appointment with the professional for a subject of the referral opportunity. | 05-14-2015 |
Humphrey Gardner, Salem, MA US
Patent application number | Description | Published |
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20090220488 | EVALUATING AND TREATING SCLERODERMA - The expression of a number of genes is altered in scleroderma. Therapeutic methods for treating scleroderma can include counteracting the effects of the altered gene expression profile. Further, scleroderma can be diagnosed and monitored by evaluating the expression of one or more of the altered genes. | 09-03-2009 |
20100233159 | METHODS OF TREATING STROKE - Methods and compositions for treating stroke are disclosed. | 09-16-2010 |
20110059069 | Gapr-1 Methods - Methods of treatment, diagnosis and screening related to GAPR-1 are disclosed. | 03-10-2011 |
Humphrey Athelstan Roy Gardner, Salem, MA US
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20130345234 | FGFR AND LIGANDS THEREOF AS BIOMARKERS FOR BREAST CANCER IN HR POSITIVE SUBJECTS - The present invention describes methods for diagnosing, treating and determining the prognosis of breast cancer HR+ patient, the methods including detecting the amplification of one or more biomarkers comprising a FGFR ligand such as FGF3, FGF4, FGF19, and/or a FGFR, such as for example FGFR1 in a subject; determining an FGFR1 inhibitor for treating the subject based on the amplification of the one or more biomarkers in the subject; administering to the subject in need thereof the FGFR1 inhibitor and using the one or more biomarkers to indicate prognosis of the subject treated with the FGFR1 inhibitor. | 12-26-2013 |
L. Patrick Gardner, Manchester, MA US
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20100088210 | FINANCIAL PORTFOLIO MANAGEMENT SYSTEM AND METHOD - A financial portfolio management system operable in a network environment can be configured to gather financial information from a plurality of sources over an electronic network and intelligently aggregate the information into a financial portfolio viewable by a client. The client can determine which accounts should be included in the portfolio. The system uses web crawling, parsing, or spidering technology to update the portfolio information. The system provides one platform that conveys financial information from a variety of accounts held at several different financial institutions. | 04-08-2010 |
20120265708 | FINANCIAL PORTFOLIO MANAGEMENT SYSTEM AND METHOD - A financial portfolio management system operable in a network environment can be configured to gather financial information from a plurality of sources over an electronic network and intelligently aggregate the information into a financial portfolio viewable by a client. The client can determine which accounts should be included in the portfolio. The system uses web crawling, parsing, or spidering technology to update the portfolio information. The system provides one platform that conveys financial information from a variety of accounts held at several different financial institutions. | 10-18-2012 |
Marty Gardner, Melrose, MA US
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20140310043 | User Interface for Travel Planning - A computer-implemented method and system provides an interactive interface for displaying results of flexible travel planning queries is described. | 10-16-2014 |
Steven D. Gardner, Westford, MA US
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20150234281 | Blade for Substrate Edge Protection During Photolithography - An apparatus protects a portion of a peripheral region ( | 08-20-2015 |
Stewart C. Gardner, Mansfield, MA US
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20090145875 | Bottle cap for a bird feeder - A bottle cap for fitting on a mouth of a bottle to form a bird feeder is disclosed. The bottle cap comprises a first chamber with an opening for receiving the mouth of the bottle and a bottom, wherein threads are provided on an inner wall of the first chamber so that the cap can be screwed onto the mouth of the bottle. A second chamber with a closed bottom is provided. An extension tube extends from the bottom of the first chamber at least partially into the second chamber, wherein liquid moves between the first and second chambers through the extension tube. At least one feeding port is provided in a side wall of the second chamber. At least one vent hole is provided in the second chamber for allowing air to be vented from the second chamber. | 06-11-2009 |
20090205572 | Bottle cap for a bird feeder - A bottle cap for fitting on a mouth of a bottle to form a bird feeder is disclosed. The bottle cap comprises a first chamber with a opening for receiving the mouth of the bottle, wherein the bottle cap snaps onto the mouth of the bottle. A second chamber is provided with a closed bottom. A sealing ring is located between the first and second chambers so as to provide a seal between the bottle cap and the mouth of the bottle when the bottle cap is snapped onto the mouth of the bottle, wherein liquid is free to move between the first and second chambers. At least one feeding port is provided in a side wall of the second chamber. | 08-20-2009 |
Stewart C. Gardner, North Attleboro, MA US
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20110237339 | Method and apparatus for playing pool - A method and apparatus for playing pool on a pool table is disclosed. A raised stand is located on the pool table and pool balls are hit into an indentation on the raised stand. For example, a plurality of pool balls is arranged in a starting position on the playing surface of the pool table. The plurality of pool balls is comprised of an object ball and a plurality of different sets of pool balls. Players alternate turns wherein each player attempts to hit balls from a set of pool balls assigned to that player into pockets in the pool table using a pool cue and a cue ball. The game ends when the object ball is hit into an indentation on a top level of the raised stand once a player has hit all of their assigned balls into the pockets | 09-29-2011 |
20110260406 | Method and apparatus for playing darts - Three dimensional targets are disclosed that can be added to a dart board. The target has a raised hard cover having a bottom surface and a top surface and sides linking the bottom surface and the top surface, wherein the top surface has at least one hole which forms a target area. The target also has attachment means on the bottom surface of the hard cover for attaching the raised projection to the playing surface of the dart board. | 10-27-2011 |
Thomas Gardner, Grafton, MA US
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20100202454 | SYSTEM AND METHOD FOR SENDING PACKETS OVER A COMPUTER NETWORK - The benefits of a multicast-enabled network are realized by a flexible, easy to deploy, software-based solution that does not require reconfiguring of network routers. Systems and methods that implement this solution can perform as follows. A packet is received that was sent by a sender to at least one receiver, and the packet includes a parameter relating to a multicast announce address. A forwarding rules set is associated with the packet if the parameter has a defined value. This forwarding rules set is used to determine whether any of the at least one destination addresses included in the packet corresponds to one of the receivers that has a receiver format that must be converted. In addition, the forwarding rules set defines when a packet should be converted from a sender format to a receiver format before forwarding the packet. The packet is converted from the sender format to the receiver format for each destination address identified as requiring conversion, and forwarded in accordance with the forwarding rules set. | 08-12-2010 |
Timothy Gardner, Needham, MA US
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20130060543 | SYSTEMS AND METHODS FOR REVERSE ENGINEERING MODELS OF BIOLOGICAL NETWORKS - The present invention provides methods and accompanying computer-based systems and computer-executable code stored on a computer-readable medium for constructing a model of a biological network. The invention further provides methods for performing sensitivity analysis on a biological network and for identifying major regulators of species in the network and of the network as a whole. In addition, the invention provides methods for identifying targets of a perturbation such as that resulting from exposure to a compound or an environmental change. The invention further provides methods for identifying phenotypic mediators that contribute to differences in phenotypes of biological systems. | 03-07-2013 |
Timothy S. Gardner, Needham, MA US
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20100234348 | COMPOSITIONS AND METHODS FOR POTENTIATING ANTIBIOTIC ACTIVITY - The present invention provides compounds that potentiate the activity of antibiotic agents, particularly quinolones such as norflaxin. The invention further provides compositions, e.g., pharmaceutical compositions, comprising the inventive compounds. The invention also provides compositions comprising an antibiotic (e.g., a quinolone) and a compound that potentiates activity of the antibiotic. The invention further provides methods of treating a subject comprising administering any of the inventive compounds or compositions to the subject. The invention also provides screening methods to identify compounds that potentiate the activity of an antibiotic, e.g., a quinolone. | 09-16-2010 |
20130311159 | SYSTEMS AND METHODS FOR REVERSE ENGINEERING MODELS OF BIOLOGICAL NETWORKS - The present invention provides methods and accompanying computer-based systems and computer-executable code stored on a computer-readable medium for constructing a model of a biological network. The invention further provides methods for performing sensitivity analysis on a biological network and for identifying major regulators of species in the network and of the network as a whole. In addition, the invention provides methods for identifying targets of a perturbation such as that resulting from exposure to a compound or an environmental change. The invention further provides methods for identifying phenotypic mediators that contribute to differences in phenotypes of biological systems. | 11-21-2013 |
William G. Gardner, Medford, MA US
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20140016793 | SPATIAL AUDIO TELECONFERENCING - Embodiments of the present invention allow participants in a networked virtual world to converse naturally as in a real-life situation. Each participant can hear “nearby” participants localized according to their positions in the virtual world, desirably with reverberation and environmental audio effects derived from properties of the virtual world. | 01-16-2014 |
William H. Gardner, Concord, MA US
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20140093760 | BATTERY CONTROL SYSTEMS - Various embodiments herein relate to the design of battery stacks, batteries and battery packs that are able to accommodate volumetric expansion in the battery materials. These designs may be especially useful in connection with batteries having negative electrodes made of lithium metal and/or positive electrodes made of an electrochemically active conversion material. These batteries may expand on the order of 10-40% during cycling. The battery designs disclosed herein include compressible regions that span a wide variety of different designs and implementations. | 04-03-2014 |
William H. Gardner, East Freetown, MA US
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20090004559 | CAP ASSEMBLY FOR A HIGH CURRENT CAPACITY ENERGY DELIVERY DEVICE - A cap assembly for use in an electrochemical cell. The cap assembly includes a tab collection post, a core insert, and at least one current collecting tab connected at one end to an electrode foil in the electrochemical cell, and horizontally connected at the other end to the tab collection post and the core insert. The at least one current collecting tab is disposed between and welded with the tab collection post and the core insert. The cap assembly also includes a shock absorber disposed around the core insert. | 01-01-2009 |
20090029240 | BATTERY CELL DESIGN AND METHODS OF ITS CONSTRUCTION - In some embodiments, a battery cell can include an assembly having an anode sheet and a cathode sheet separated by separator membranes, each sheet having an electroactive layer on a current collector. At least one of the current collectors can be in electrical communication with conducting tabs that extend from at least one of the anode sheet and the cathode sheet, the conducting tabs extends from an end face of the spirally wound assembly. In addition, the cell can include a first tab insulator having concentrically positioned outer and inner members, each of the outer and inner members having at least one slot that allows one or more of the plurality of conducting tabs to pass through. The inner and outer members are adjustable with respect to relative angular orientation of the at least one slot on the outer and inner members of the first tab insulator. | 01-29-2009 |
20090104510 | LITHIUM RECHARGEABLE CELL WITH REFERENCE ELECTRODE FOR STATE OF HEALTH MONITORING - A battery management system includes one or more lithium ion cells in electrical connection, each said cell comprising: first and second working electrodes and one or more reference electrodes, each reference electrode electronically isolated from the working electrodes and having a separate tab or current collector exiting the cell and providing an additional terminal for electrical measurement; and a battery management system comprising a battery state-of-charge monitor, said monitor being operable for receiving information relating to the potential difference of the working electrodes and the potential of one or more of the working electrodes versus the reference electrode. | 04-23-2009 |
20090169990 | Battery Cell Design With Asymmetrical Terminals - An electrochemical cell is provided. The cell includes a plurality of electrode sheets separated by at least one separator sheet. A positive extension tab is attached to a current collecting tabs of positive electrode sheets, and a negative extension tab is attached to current collecting tabs of the negative electrode sheets. The dimensions of the positive extension tab and the negative extension tab are selected such that temperature difference between positive extension tab and the negative extension tab are minimized when the electrochemical cell is in use. | 07-02-2009 |
20100266893 | Method and Design for Externally Applied Laser Welding of Internal Connections in a High Power Electrochemical Cell - An electrochemical cell includes components that are welded from an external source after the components are assembled in a cell canister. The cell canister houses electrode tabs and a core insert. An end cap insert is disposed opposite the core insert. An external weld source, such as a laser beam, is applied to the end cap insert, such that the end cap insert, the electrode tabs, and the core insert are electrically coupled by a weld which extends from the end cap insert to the core insert. | 10-21-2010 |
20120263986 | LITHIUM RECHARGEABLE CELL WITH REFERENCE ELECTRODE FOR STATE OF HEALTH MONITORING - A battery management system includes one or more lithium ion cells in electrical connection, each said cell comprising: first and second working electrodes and one or more reference electrodes, each reference electrode electronically isolated from the working electrodes and having a separate tab or current collector exiting the cell and providing an additional terminal for electrical measurement; and a battery management system comprising a battery state-of-charge monitor, said monitor being operable for receiving information relating to the potential difference of the working electrodes and the potential of one or more of the working electrodes versus the reference electrode. | 10-18-2012 |
20130108903 | Electrical Insulator for Electrochemical Cell | 05-02-2013 |
20140023888 | LITHIUM RECHARGABLE CELL WITH REFERENCE ELECTRODE FOR STATE OF HEALTH MONITORING - A battery management system includes one or more lithium ion cells in electrical connection, each said cell comprising: first and second working electrodes and one or more reference electrodes, each reference electrode electronically isolated from the working electrodes and having a separate tab or current collector exiting the cell and providing an additional terminal for electrical measurement; and a battery management system comprising a battery state-of-charge monitor, said monitor being operable for receiving information relating to the potential difference of the working electrodes and the potential of one or more of the working electrodes versus the reference electrode. | 01-23-2014 |
William H. Gardner, Waltham, MA US
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20150155596 | MULTI-CELL LITHIUM-ION BATTERIES - Lithium ion (Li-ion) multi-cell batteries in which the requirements for individual monitoring and controlling charging of each cell, the requirements for monitoring and controlling charge balancing and the effects of repeated charging and discharging are ameliorated are presented. In one or more embodiments, the multi-cell battery includes configuration material that substantially provides a moisture barrier. | 06-04-2015 |