Patent application number | Description | Published |
20120147943 | Method and Apparatus for Complex In-Phase/Quadrature Polyphase Nonlinear Equalization - Complex polyphase nonlinear equalizer (cpNLEQs) mitigate nonlinear distortions generated by complex in-phase/quadrature (I/Q) time-interleaved analog-to-digital converters (TIADCs). Example cpNLEQs upsample the digital waveform emitted by the TIADC, e.g., by a factor of two, then separate the upsampled digital waveform into upsampled in-phase and quadrature components. Processors in the cpNLEQs create real and imaginary nonlinear compensation terms from the upsampled in-phase and quadrature components. The nonlinear compensation terms are downsampled, and the downsampled imaginary nonlinear compensation term is phase-shifted, then combined with the downsampled real component to produce an estimated residual distortion. Subtracting the estimated residual distortion from the digital waveform emitted by the TIADC yields an equalized digital waveform suitable for further processing. | 06-14-2012 |
20120176190 | Polyphase Nonlinear Digital Predistortion - Polyphase nonlinear digital predistorters (pNDPs) mitigate nonlinear distortions generated by time-interleaved digital-to-analog converters (TIDACs). Processors in an example pNDP compute nonlinear and linear compensation terms representative of channel mismatches and other imperfections in the TIDAC based on the digital input to the TIDAC. The pNDP subtracts these compensation terms from a delayed copy of the digital input to yield a predistorted digital input. The TIDAC converts on the predistorted digital input into a fullband analog output that is substantially free of nonlinear distortion. | 07-12-2012 |
20120176191 | DIGITAL COMPENSATION OF A NONLINEAR SYSTEM - A method for digital compensation of a nonlinear system comprises identifying a plurality of circuit parameters of a nonlinear system. Each circuit parameter determines a nonlinear response of the nonlinear system. A first circuit parameter is chosen from the plurality of circuit parameters. The first circuit parameter determines a first effect on the nonlinear response. The first effect is at least as large a second effect from a second circuit parameter from the plurality of circuit parameters. At least one stimulus is applied to the nonlinear system. The nonlinear response of the nonlinear system is measured in response to the at least one stimulus. A compensation architecture is synthesized to substantially linearize the nonlinear response. The compensation architecture receives the nonlinear response of the nonlinear system and provides a substantially linear response. | 07-12-2012 |
20140029658 | Analog/Digital Co-Design Methodology to Achieve High Linearity and Low Power Dissipation in a Radio Frequency (RF) Receiver - Receiver design techniques are provided that are capable of producing relatively efficient, linear radio frequency (RF) receivers. During a design process, components of an analog receiver chain and digital nonlinearity compensation techniques are considered together to achieve reduced power consumption in the receiver. | 01-30-2014 |
20140029660 | Method and Apparatus for Sparse Polynomial Equalization of RF Receiver Chains - A radio frequency (RF) receiver includes an analog receiver chain followed by digital circuitry for reducing nonlinear distortion components within an output signal of the analog receiver chain. In at least one embodiment, the digital circuitry includes a digital equalizer that is configured with a sparse set of Volterra series coefficients. In this manner, a desired level of linearity performance may be achieved in the receiver with relatively low power consumption. | 01-30-2014 |
20140030995 | Analog/Digital Co-Design Methodology to Achieve High Linearity and Low Power Dissipation in a Radio Frequency (RF) Receiver - Receiver design techniques are provided that are capable of producing relatively efficient, linear radio frequency (RF) receivers. During a design process, components of an analog receiver chain and digital nonlinearity compensation techniques are considered together to achieve reduced power consumption in the receiver. | 01-30-2014 |
Patent application number | Description | Published |
20090253758 | Selective androgen receptor modulators - This invention provides compounds of formulas I, Ia, Ib, Ic, Id, Ie, and or salts thereof, pharmaceutical compositions comprising a compound of formulas I, Ia, Ib, Ic, Id, Ie, and a pharmaceutically acceptable excipient, methods of modulating the androgen receptor, methods of treating diseases beneficially treated by an androgen receptor modulator (e.g., sarcopenia, prostate cancer, contraception, type 2 diabetes related disorders or diseases, anemia, depression, and renal disease) and processes for making compounds of formulas I, Ia, Ib, Ic, Id, Ie, and intermediates useful in the preparation of same. | 10-08-2009 |
20100041721 | SELECTIVE ANDROGEN RECEPTOR MODULATORS - This invention provides compounds of formulas I, Ia, Ib, Ic, Id, Ie, If or Ig or salts thereof, pharmaceutical compositions comprising a compound of formulas I, Ia, Ib, Ic, Id, Ie, If or Ig and a pharmaceutically acceptable excipient, methods of modulating the androgen receptor, methods of treating diseases beneficially treated by an androgen receptor modulator (e.g., sarcopenia, prostate cancer, contraception, type 2 diabetes related disorders or diseases, anemia, depression, and renal disease) and processes for making compounds of formulas I, Ia, Ib, Ic, Id, Ie, If or Ig and intermediates useful in the preparation of same. | 02-18-2010 |
20110224267 | Selective androgen receptor modulators - This invention provides compounds of formulas I, Ia, Ib, Ic, Id, Ie, and or salts thereof, pharmaceutical compositions comprising a compound of formulas I, Ia, Ib, Ic, Id, Ie, and a pharmaceutically acceptable excipient, methods of modulating the androgen receptor, methods of treating diseases beneficially treated by an androgen receptor modulator (e.g., sarcopenia, prostate cancer, contraception, type 2 diabetes related disorders or diseases, anemia, depression, and renal disease) and processes for making compounds of formulas I, Ia, Ib, Ic, Id, Ie, and intermediates useful in the preparation of same. | 09-15-2011 |
20120004270 | Selective Androgen Receptor Modulators - This invention provides compounds as described herein or pharmaceutically acceptable salte thereof, pharmaceutical compositions comprising a compound as described herein or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable excipient, methods of modulating the androgen receptor using the compounds or compositions described herein, methods of treating diseases beneficially treated by an androgen receptor modulator (e.g., sarcopenia, prostate cancer, contraception, type 2 diabetes related disorders or diseases, anemia, depression, and renal disease) using the compounds and compositions described herein and processes for making compounds described herein and intermediates useful in the preparation of same. | 01-05-2012 |
20130116288 | Selective Androgen Receptor Modulators - This invention provides compounds of formulas I, Ia, Ib, Ic, Id, Ie, If or Ig or salts thereof, pharmaceutical compositions comprising a compound of formulas I, Ia, Ib, Ic, Id, If or Ig and a pharmaceutically acceptable excipient, methods of modulating the androgen receptor, methods of treating diseases beneficially treated by an androgen receptor modulator (e.g., sarcopenia, prostate cancer, contraception, type 2 diabetes related disorders or diseases, anemia, depression, and renal disease) and processes for making compounds of formulas I, Ia, Ib, Ic, Id, Ie, If or Ig and intermediates useful in the preparation of same. | 05-09-2013 |
Patent application number | Description | Published |
20110071395 | TRANSESOPHAGEAL AND TRANSNASAL, TRANSESOPHAGEAL ULTRASOUND IMAGING SYSTEMS - A semi-invasive ultrasound imaging system for imaging biological tissue includes a transesophageal probe or a transnasal, transesophageal probe connected to a two-dimensional ultrasound transducer array, a transmit beamformer, a receive beamformer, and an image generator. The two-dimensional transducer array is disposed on a distal portion of the probe's elongated body. The transmit beamformer is connected to the transducer array and is constructed to transmit several ultrasound beams over a selected pattern defined by azimuthal and elevation orientations. The receive beamformer is connected to the transducer array and is constructed to acquire ultrasound data from the echoes reflected over a selected tissue volume. The tissue volume is defined by the azimuthal and elevation orientations and a selected scan range. The receive beamformer is constructed to synthesize image data from the acquired ultrasound data. The image generator is constructed to receive the image data and generate images that are displayed on an image display. Preferably, the image generator is constructed to generate, from the image data, several orthographic projection views over the selected tissue volume. | 03-24-2011 |
20110137176 | ULTRASOUND TRANSDUCER FINGER PROBE - Finger probe for use in ultrasonic imaging includes a housing and a matrix array arranged within the housing to produce ultrasound beams and which includes a plurality of independently-addressable transducer elements. A finger clip is coupled to the housing and arranged to accommodate an operator's finger. A control unit is coupled to the transducer elements to provide planar and volumetric scanning capabilities. A system and method for ultrasonically interrogating a patient's body part and for producing ultrasound images based on the interrogation using a finger-mounted ultrasound probe are also disclosed. | 06-09-2011 |
20140276085 | COREGISTERED INTRAVASCULAR AND ANGIOGRAPHIC IMAGES - Presenting intravascular images and angiographic images co-registered on a display. As an imaging catheter is pushed through an occlusion, a center point of the catheter and an outline of the vessel wall can be displayed. A physician can see where the catheter is crossing the occlusion within the vessel. The physician can determine what path the catheter is taking the through occlusion. Methods include extending an imaging catheter through the occlusion, determining a location of a wall of the vessel relative to a center point of the catheter, obtaining a position of the catheter within a lumen of the vessel via angiography, and displaying the catheter crossing the occlusion by co-registering the location of the wall, the position of the catheter within the lumen, and the lumen on a display. | 09-18-2014 |
20140276086 | DEFLECTABLE IVUS CATHETER - The invention generally relates to intravascular intervention catheters and provides catheters for performing an intravascular procedure that use a mechanism to control an operation at the end of the catheter. The mechanism can be used to steer the distal tip of the catheter from a controller at a proximal end of the catheter. The mechanism may include one or more pull wires extending along the catheter. The mechanism may optionally be manually or computer controlled. | 09-18-2014 |
20140276771 | SYSTEMS AND METHODS FOR CONTROLLED TISSUE ABLATION - The invention describes methods for safely delivering ablation energy to a tissue, e.g., thrombus, in need of ablation therapy. The method uses a catheter adapted for IVUS imaging, ablation, and impedance measurements to monitor the impedance of a tissue receiving ablation energy. In an embodiment, a user may view an IVUS image of the tissue with impedance measurements to determine if it is safe to deliver additional energy. In another embodiment, a processor is configured to determine if it is safe to deliver additional ablation energy based upon the impedance measurement. | 09-18-2014 |
20140276923 | VIBRATING CATHETER AND METHODS OF USE - The invention provides a method of intravascular intervention that includes inserting a catheter comprising an extended body into a lumen within tissue of a patient, advancing the catheter to a treatment site, vibrating a proximal end of the catheter with a mechanical vibrator, and treating the treatment site while a distal end of the catheter is vibrating. | 09-18-2014 |
20140277012 | VIBRATING GUIDEWIRE TORQUER AND METHODS OF USE - The invention provides a method of intravascular intervention that includes inserting a guidewire comprising an extended body into a lumen within tissue of a patient, advancing the guidewire into a chronic total occlusion, vibrating a proximal end of the guidewire with a mechanical vibrator, and crossing the chronic total occlusion while a distal end of the guidewire is vibrating. | 09-18-2014 |
Patent application number | Description | Published |
20090097356 | PROCESSING OF COMBINED SURFACE AND BOREHOLE SEISMIC DATA - Methods and related systems are described for processing surface seismic data. Surface seismic data representing seismic signals detected at a plurality of surface locations is wavefield deconvolved using a combination of direct wave travel times estimated from borehole seismic data, and wavefield energy estimated from the surface seismic data. | 04-16-2009 |
20090159272 | MONITORING, CONTROLLING AND ENHANCING PROCESSES WHILE STIMULATING A FLUID-FILLED BOREHOLE - Tubewaves are used for detection and monitoring of feature state to enhance stimulation operations and remediate failure conditions. For example, proper sealing of perforations may be confirmed based on lack of a reflection of a tubewave by the perforations. Alternatively, at least one of amplitude, frequency, attenuation, dispersion and travel time associated with a tubewave and reflection may be used to determine feature state. If a sealant fails during treatment then the failure condition is indicated by appearance of a tubewave reflection. Consequently, the stimulation operation can be stopped in a timely manner, and remediation by means, for example, of pumping diversion fluid or dropping of balls, can be reinitiated until the difference between the expected responses and responses measured by the instrument along the segment to be stimulated confirm that sealing has taken place and that stimulation of the intended zone can resume. Further, specific remediation steps may be selected based on response of the borehole system to tubewaves. The efficacy of the selected remediation steps may also be determined by response of the borehole system to tubewaves during or after execution of those steps. | 06-25-2009 |
20100157737 | MICROHYDRAULIC FRACTURING WITH DOWNHOLE ACOUSTIC MEASUREMENT - Methods and related systems are described for measuring acoustic signals in a borehole during a fracturing operation. The system includes a downhole toolstring designed and adapted for deployment in a borehole formed within a subterranean rock formation. A downhole rock fracturing tool opens and propagates a fracture in the subterranean rock formation. Dipole and/or quadrupole acoustic sources transmit acoustic energy into the subterranean rock formation. A receiver array measures acoustic energy traveling through the subterranean rock formation before, during and after the fracture induction. Geophones mounted on extendable arms can be used to measure shear wave acoustic energy travelling in the rock formation. The toolstring can be constructed such that the sources and receivers straddle the fracture zone during the fracturing. Alternatively, the sources or the receivers can co-located axially with the fracture zone, or the toolstring can be repositioned following fracturing such that the fracture zone is between the acoustic sources and receivers. | 06-24-2010 |
20100302903 | ESTIMATING SUBSURFACE ELASTIC PARAMETERS - A method for estimating subsurface elastic parameters is described herein. One or more slowness vectors may be determined based on a vertical seismic profile of a subsurface area. A model containing anisotropy parameters and a well deviation estimate may be generated based on survey data. The slowness vectors may be corrected for the well deviation estimate based on the model. One or more modeled slowness vectors may be calculated using the corrected slowness vectors and the anisotropy parameters in the model. | 12-02-2010 |
20110079389 | METHOD FOR TREATING WELL BORE WITHIN A SUBTERRANEAN FORMATION - The invention discloses a method of creating a polymerized composition in a well bore: providing a polymerizable composition made of a polymerization initiator and a monomer polymerizable by frontal polymerization; introducing the polymerizable composition into the wellbore; exposing the polymerizable composition to a trigger to activate the frontal polymerization; and creating the polymerized composition. | 04-07-2011 |
20110267922 | MECHANICAL TUBE WAVE SOURCES AND METHODS OF USE FOR LIQUID FILLED BOREHOLES - The current application discloses methods and systems for generating mechanical tube waves in fluid filled boreholes penetrating subterranean formations. In one embodiment, the system of the current application comprises an energy storage chamber; a fast operating valve connected to the energy storage chamber; a pipe connected to the valve and extending to the liquid-filled borehole; where said energy storage chamber contains a first pressure that is substantially different from a second pressure in the pipe so that a fast operation of the valve generates a tube wave in the pipe. | 11-03-2011 |
20110292763 | DETECTION OF SEISMIC SIGNALS USING FIBER OPTIC DISTRIBUTED SENSORS - A fiber optic distributed vibration system for detecting seismic signals in an earth formation is provided. The system includes a fiber optic cable deployed in a borehole that extends into the earth formation and which is configured to react along its length to a seismic wave incident on the fiber optic cable from outside the borehole. An optical source launches an optical signal into the fiber optic cable while the seismic wave is incident thereon. A receiver detects coherent Rayleigh noise (CRN) produced in response to the optical signal. A processing circuit processes the detected CRN signal to determine characteristics of the earth formation. | 12-01-2011 |
20120035854 | SEISMIC ACQUISITION SYSTEM INCLUDING A DISTRIBUTED SENSOR HAVING AN OPTICAL FIBER - A seismic acquisition system includes a distributed optical sensor (having an optical fiber) and an interrogation subsystem configured to generate a light signal to emit into the optical fiber. The interrogation subsystem receives, from the distributed optical sensor, backscattered light responsive to the emitted light signal, wherein the backscattered light is affected by one or both of seismic signals reflected from a subterranean structure and noise. Output data corresponding to the backscattered light is provided to a processing subsystem to determine a characteristic of the subterranean structure. | 02-09-2012 |
20140064028 | DETECTION OF SEISMIC SIGNALS USING FIBER OPTIC DISTRIBUTED SENSORS - A fiber optic distributed vibration system for detecting seismic signals in an earth formation is provided. The system includes a fiber optic cable deployed in a borehole that extends into the earth formation and which is configured to react along its length to a seismic wave incident on the fiber optic cable from outside the borehole. An optical source launches an optical signal into the fiber optic cable while the seismic wave is incident thereon. A receiver detects coherent Rayleigh noise (CRN) produced in response to the optical signal. A processing circuit processes the detected CRN signal to determine characteristics of the earth formation. | 03-06-2014 |
20150076334 | SEISMIC ACQUISITION SYSTEM INCLUDING A DISTRIBUTED SENSOR HAVING AN OPTICAL FIBER - A seismic acquisition system includes a distributed optical sensor (having an optical fiber) and an interrogation subsystem configured to generate a light signal to emit into the optical fiber. The interrogation subsystem receives, from the distributed optical sensor, backscattered light responsive to the emitted light signal, wherein the backscattered light is affected by one or both of seismic signals reflected from a subterranean structure and noise. Output data corresponding to the backscattered light is provided to a processing subsystem to determine a characteristic of the subterranean structure. | 03-19-2015 |
Patent application number | Description | Published |
20120130423 | SURGICAL FILAMENT SNARE ASSEMBLIES - A surgical filament snare assembly including an anchor capable of being fixated in bone and having a filament engagement feature. A first filament has a noose on a first portion of at least a first limb and has a second portion connected to the filament engagement feature of the anchor. Preferably, at least one free filament limb, which in some embodiments is a length of the first filament and in other embodiments is a second filament, is capable of being passed through tissue to be repaired and has at least one end passable through the noose to enable incremental tensioning of the tissue after the anchor is fixated in bone. The noose strangulates the free filament limb when tension is applied to at least one of the free filament limb and the noose. | 05-24-2012 |
20120130424 | SURGICAL FILAMENT SNARE ASSEMBLIES - A surgical filament snare assembly including an anchor capable of being fixated in bone and having a filament engagement feature. A first filament has a noose with first and second noose limbs connected, preferably slidably connected, to the filament engagement feature of the anchor. The first and second noose limbs emerge from the anchor as first and second free filament limbs which are capable of being passed through tissue to be repaired and then passable through the noose. The noose, such as one or more half-hitches, is capable of receiving the free filament limbs and strangulating them when tension is applied to at least one of the free filament limbs and the noose to enable incremental tensioning of the tissue after the anchor is fixated. Preferably, the snare assembly further includes a flexible sleeve joining at least some portion of the first and second free filament limbs to facilitate passing of the free filament limbs at least through the tissue as a single unit. | 05-24-2012 |
20120165864 | ADJUSTABLE ANCHOR SYSTEMS AND METHODS - An adjustable anchor system for securing tissue to bone, including an anchor having at least one passage extending from a proximal end toward a distal end. The passage defines a restriction such as a restricted opening. The anchor has at least one bone-engaging feature disposed between the proximal and distal ends. The system further includes a first material formed as a closed loop and capable of being placed through a portion of the tissue, and a second filament having a terminal end, a post limb and a sliding knot tied between the terminal end and the post limb to establish an elongated, adjustable-length loop which extends beyond the proximal end of the anchor and captures the closed loop of the first material. The knot of the second filament is restrained by the restricted opening when tension is applied as desired to the post limb to shorten the elongated loop to draw the tissue toward the anchor. | 06-28-2012 |
20120179199 | ADJUSTABLE ANCHOR SYSTEMS AND METHODS - An adjustable anchor system provides for securing tissue to bone and includes an anchor with a collapsible suture loop affixed thereto and a tissue suture connected to the collapsible suture loop. After the tissue suture is loaded into the tissue and the anchor implanted into the bone the collapsible loop is collapsed to tension the tissue suture. | 07-12-2012 |
20130079817 | COMPLIANT INSERTER FOR IMPLANTS - An improved implant inserter, and method of using same, with an elongated, substantially rigid shaft having a proximal surface which is capable of receiving a driving force, and a substantially rigid tip portion having a distal end and a proximal end. At least the distal end of the tip portion is capable of being placed within an implant such as a suture anchor. The inserter further includes a compliant region disposed between the tip portion and the shaft which requires less lateral force to bend than the tip portion, at least when the tip portion has been placed within the implant. | 03-28-2013 |
20140188165 | MULTI-PIECE ANCHOR INSERTER - Various devices, systems, and methods are provided for securing soft tissue to bone. In one exemplary embodiment, a two-piece inserter tool is provided that includes a tip portion that is configured to be removably coupled to a handle portion. A distal portion of the tip portion can be configured to be coupled to a suture anchor, and the tip portion and the anchor can be passed through a continuous suture loop prior to mating the tip portion to the handle portion. | 07-03-2014 |
Patent application number | Description | Published |
20100091478 | Chemiluminescent aerosol spray - This invention relates to a stable, multiple-use chemiluminescent marking system capable of articulating, communicating, displaying and conveying chemiluminescent messages in the form of written text, numerics, alpha-numerics, figures, drawings, emergency messages, distress calls or directional traffic indicators. The invention functions by co-dispensing two vessels, each of which are pressurized by means of a liquid miscible propellant. The chemical ingredients from each vessel are combined by means of a mixing valve attached to the actuators of each vessel, which simultaneously eject the contents of both vessels and produce a ballistic chemiluminescent aerosol spray. In another aspect of this invention, each vessel has an internal pressure of 1 atmosphere and an aerosol spray is produced by a hand or finger-actuated co-dispensing pump spray. | 04-15-2010 |
20120076930 | Chemiluminescent Aerosol Spray - This invention relates to a stable, highly visible, multiple use, chemiluminescent composition of matter and aerosol system capable of articulating, communicating, displaying or marking, night-time chemiluminescent messages, in the form of written text, numerics, alpha-numerics, figures, drawings, emergency messages, trail markings, lanterns or distress calls, directly onto various substrates and surfaces, including dark or non-reflective objects and outdoor natural surfaces such as grass, trees or land. | 03-29-2012 |
Patent application number | Description | Published |
20080241232 | Use of green porphyrins to treat neovasculature in the eye - Photodynamic therapy of conditions of the eye characterized by unwanted neovasculature, such as age-related macular degeneration, is effective using green porphyrins as photoactive agents, preferably as liposomal compositions. | 10-02-2008 |
20090286743 | Methods and Compositions for Treating Conditions of the Eye - Provided are methods and compositions for the photodynamic therapy (PDT) of ocular conditions characterized by the presence of unwanted choroidal neovasculature, for example, neovascular age-related macular degeneration. The selectivity and sensitivity of the PDT method can be enhanced by combining the PDT with an anti-angiogenesis factor, for example, angiostatin or endostatin, or with an apoptosis-modulating factor. Furthermore, the selectivity and sensitivity of the PDT may be further enhanced by coupling a targeting moiety to the photosensitizer so as to target the photosensitizer to choroidal neovasculature. | 11-19-2009 |
20100189801 | Drug Delivery Systems and Use Thereof - The invention provides a microsphere formulation for the sustained delivery of an aptamer, for example, an anti-Vascular Endothelial Growth Factor aptamer, to a preselected locus in a mammal, such as the eye. In addition, the invention provides methods for making such formulations, and methods of using such formulations to deliver an aptamer to a preselected locus in a mammal. In particular, the invention provides a method for delivering the aptamer to an eye for the treatment of an ocular disorder, for example, age-related macular degeneration. | 07-29-2010 |
20110137228 | Use of Green Porphyrins to Treat Neovasculature in the Eye - Photodynamic therapy of conditions of the eye characterized by unwanted neovasculature, such as age-related macular degeneration, is effective using green porphyrins as photoactive agents, preferably as liposomal compositions. | 06-09-2011 |
20110144035 | Methods and Compositions for Treating Conditions of the Eye - Provided are methods and compositions for the photodynamic therapy (PDT) of ocular conditions characterized by the presence of unwanted choroidal neovasculature, for example, neovascular age-related macular degeneration. The selectivity and sensitivity of the PDT method can be enhanced by combining the PDT with an anti-angiogenesis factor, for example, angiostatin or endostatin, or with an apoptosis-modulating factor. Furthermore, the selectivity and sensitivity of the PDT may be further enhanced by coupling a targeting moiety to the photosensitizer so as to target the photosensitizer to choroidal neovasculature. | 06-16-2011 |
20110159004 | Methods and Compositions for Preserving the Viability of Photoreceptor Cells - Provided are methods and compositions for maintaining the viability of photoreceptor cells following retinal detachment. The viability of photoreceptor cells can be preserved by administering an apoptosis inhibitor to a mammal having an eye with retinal detachment. The apoptosis inhibitor maintains the viability of the photoreceptor cells until such time that the retina becomes reattached to the underlying retinal pigment epithelium and choroid. The treatment minimizes the loss of vision, which otherwise may occur as a result of retinal detachment. | 06-30-2011 |
20110189191 | Methods and Compositions for Treating Conditions of the Eye - Provided are methods and compositions for treating ocular conditions characterized by the presence of unwanted choroidal neovasculature, for example, neovascular age-related macular degeneration. The selectivity and sensitivity of, for example, a photodynamic therapy (PDT)-based approach can be enhanced by combining the PDT with an anti-FasL factor, for example, an anti-FasL neutralizing antibody. | 08-04-2011 |
20120165383 | INFLAMMATORY EYE DISEASE - The present invention provides methods, kits and compositions for treating uveitis in a subject using Hsp90 inhibitors. | 06-28-2012 |
20120201859 | Drug Delivery Systems and Use Thereof - The invention provides a microsphere formulation for the sustained delivery of an aptamer, for example, an anti-Vascular Endothelial Growth Factor aptamer, to a preselected locus in a mammal, such as the eye. In addition, the invention provides methods for making such formulations, and methods of using such formulations to deliver an aptamer to a preselected locus in a mammal. In particular, the invention provides a method for delivering the aptamer to an eye for the treatment of an ocular disorder, for example, age-related macular degeneration. | 08-09-2012 |
20120323162 | Methods and Compositions for Treating Conditions of the Eye - Provided are methods and compositions for the photodynamic therapy (PDT) of ocular conditions characterized by the presence of unwanted choroidal neovasculature, for example, neovascular age-related macular degeneration. The selectivity and sensitivity of the PDT method can be enhanced by combining the PDT with an anti-angiogenesis factor, for example, angiostatin or endostatin, or with an apoptosis-modulating factor. Furthermore, the selectivity and sensitivity of the PDT may be further enhanced by coupling a targeting moiety to the photosensitizer so as to target the photosensitizer to choroidal neovasculature. | 12-20-2012 |
20130072849 | USE OF GREEN PORPHYRINS TO TREAT NEOVASCULATURE IN THE EYE - Photodynamic therapy of conditions of the eye characterized by unwanted neovasculature, such as age-related macular degeneration, is effective using green porphyrins as photoactive agents, preferably as liposomal compositions. | 03-21-2013 |
20130137642 | METHODS AND COMPOSITIONS FOR PRESERVING PHOTORECEPTOR AND RETINAL PIGMENT EPITHELIAL CELLS - Provided are methods and compositions for maintaining the viability of photoreceptor cells and/or retinal pigment epithelial cells in a subject with an ocular disorder including, for example, age-related macular degeneration (AMD) (e.g., dry or neovascular AMD), retinitis pigmentosa (RP), or a retinal detachment. The viability of the photoreceptor cells and/or the retinal pigment epithelial cells can be preserved by administering a necrosis inhibitor either alone or in combination with an apoptosis inhibitor to a subject having an eye with the ocular condition. The compositions, when administered, maintain the viability of the cells, thereby minimizing the loss of vision or visual function associated with the ocular disorder. | 05-30-2013 |
20130209570 | DRUG DELIVERY SYSTEMS AND USE THEREOF - The invention provides a microsphere formulation for the sustained delivery of an aptamer, for example, an anti-Vascular Endothelial Growth Factor aptamer, to a preselected locus in a mammal, such as the eye. In addition, the invention provides methods for making such formulations, and methods of using such formulations to deliver an aptamer to a preselected locus in a mammal. In particular, the invention provides a method for delivering the aptamer to an eye for the treatment of an ocular disorder, for example, age-related macular degeneration. | 08-15-2013 |
20140024598 | METHODS AND COMPOSITIONS FOR PRESERVING RETINAL GANGLION CELLS - Provided are methods and compositions for maintaining the viability of retinal ganglion cells in a subject with an ocular disorder including, for example, glaucoma and optic nerve injury. The viability of the retinal ganglion cells can be preserved by administering a necrosis inhibitor either alone or in combination with an apoptosis inhibitor to a subject having an eye with the ocular condition. The compositions, when administered, maintain the viability of the cells and/or promote axon regeneration, thereby minimizing the loss of vision or visual function associated with the ocular disorder. | 01-23-2014 |
20140088182 | INFLAMMATORY EYE DISEASE - The present invention provides methods, kits and compositions for treating uveitis in a subject using Hsp90 inhibitors. | 03-27-2014 |
20140163451 | Methods and Compositions for Treating Conditions of the Eye - Provided are methods and compositions for the photodynamic therapy (PDT) of ocular conditions characterized by the presence of unwanted choroidal neovasculature, for example, neovascular age-related macular degeneration. The selectivity and sensitivity of the PDT method can be enhanced by combining the PDT with an anti-angiogenesis factor, for example, angiostatin or endostatin, or with an apoptosis-modulating factor. Furthermore, the selectivity and sensitivity of the PDT may be further enhanced by coupling a targeting moiety to the photosensitizer so as to target the photosensitizer to choroidal neovasculature. | 06-12-2014 |
20140178407 | Methods and Compositions for Treating Conditions of the Eye - Provided are methods and compositions for treating ocular conditions characterized by the presence of unwanted choroidal neovasculature, for example, neovascular age-related macular degeneration. The selectivity and sensitivity of, for example, a photodynamic therapy (PDT)-based approach can be enhanced by combining the PDT with an anti-FasL factor, for example, an anti-FasL neutralizing antibody. | 06-26-2014 |
20140328937 | Drug Delivery Systems and Use Thereof - The invention provides a microsphere formulation for the sustained delivery of an aptamer, for example, an anti-Vascular Endothelial Growth Factor aptamer, to a preselected locus in a mammal, such as the eye. In addition, the invention provides methods for making such formulations, and methods of using such formulations to deliver an aptamer to a preselected locus in a mammal. In particular, the invention provides a method for delivering the aptamer to an eye for the treatment of an ocular disorder, for example, age-related macular degeneration. | 11-06-2014 |
Patent application number | Description | Published |
20080208325 | Medical articles for long term implantation - According to an aspect of the present invention, long term medical articles are provided which include the following: (a) first and second body contacting (e.g., tissue and/or body-fluid contacting) porous polymeric layers; (b) a polymeric barrier layer disposed between the first and second porous polymer layers; and (c) a reinforcement element. According to another aspect of the present invention, tubular medical articles for long term implantation are provided, which comprise: (a) a reinforcement element; (b) a blood contacting porous polymeric layer having a surface energy ranging between 20 and 30 dynes/cm disposed over an inner surface of the reinforcement element; and (c) an additional porous polymeric layer formed over an outer surface of the reinforcement element. | 08-28-2008 |
20090220677 | METHOD OF MANUFACTURING A COVERED STENT - A method of manufacturing a covered stent having a sufficiently thick covering to retain a therapeutically effective amount of a therapeutic agent. The covering is applied to the entire outer surface of the stent to provide sufficient volume for retention of the therapeutic agent. In certain embodiments, the stent has a plurality of openings that are covered by the covering. The invention is particularly suited for certain applications, such as for the manufacture of non-vascular stents. | 09-03-2009 |
20120121665 | IMPLANTABLE OR INSERTABLE MEDICAL DEVICE RESISTANT TO MICROBIAL GROWTH AND BIOFILM FORMATION - Disclosed are implantable or insertable medical devices that provide resistance to microbial growth on and in the environment of the device and resistance to microbial adhesion and biofilm formation on the device. In particular, the invention discloses implantable or insertable medical devices that comprise at least one biocompatible matrix polymer region, an antimicrobial agent for providing resistance to microbial growth and a microbial adhesion/biofilm synthesis inhibitor for inhibiting the attachment of microbes and the synthesis and accumulation of biofilm on the surface of the medical device. Also disclosed are methods of manufacturing such devices under conditions that substantially prevent preferential partitioning of any of said bioactive agents to a surface of the biocompatible matrix polymer and substantially prevent chemical modification of said bioactive agents | 05-17-2012 |
20120128793 | IMPLANTABLE OR INSERTABLE MEDICAL DEVICE RESISTANT TO MICROBIAL GROWTH AND BIOFILM FORMATION - Disclosed are implantable or insertable medical devices that provide resistance to microbial growth on and in the environment of the device and resistance to microbial adhesion and biofilm formation on the device. In particular, the invention discloses implantable or insertable medical devices that comprise at least one biocompatible matrix polymer region, an antimicrobial agent for providing resistance to microbial growth and a microbial adhesion/biofilm synthesis inhibitor for inhibiting the attachment of microbes and the synthesis and accumulation of biofilm on the surface of the medical device. Also disclosed are methods of manufacturing such devices under conditions that substantially prevent preferential partitioning of any of said bioactive agents to a surface of the biocompatible matrix polymer and substantially prevent chemical modification of said bioactive agents | 05-24-2012 |
20120150096 | IMPLANTABLE OR INSERTABLE MEDICAL DEVICES FOR CONTROLLED DRUG DELIVERY - Implantable or insertable medical devices are provided, which comprises: (a) a biocompatible polymer; and (b) at least one therapeutic agent selected from an anti-inflammatory agent, an analgesic agent, an anesthetic agent, and an antispasmodic agent. The medical devices are adapted for implantation or insertion at a site associated with pain or discomfort upon implantation or insertion. In many embodiments, the therapeutic will be selected from at least one of (i) ketorolac and pharmaceutically acceptable salts thereof (e.g., ketorolac tromethamine) and (ii) 4-diethylamino-2-butynylphenylcyclohexyl glycolate and pharmaceutically acceptable salts thereof (e.g., oxybutynin chloride). Also provided are uses for the implantable or insertable medical devices, which uses comprise reducing pain or discomfort accompanying the implantation or insertion of such devices. Further uses may comprise reducing microbial buildup along the device. Methods for manufacturing implantable or insertable medical devices are also provided. | 06-14-2012 |
Patent application number | Description | Published |
20080218817 | SYSTEM AND METHOD FOR MAKING SEAMLESS HOLOGRAMS, OPTICALLY VARIABLE DEVICES AND EMBOSSING SUBSTRATES - Apparatus and method for producing optically variable devices, optically variable media, dot matrix holograms or embossing substrates. The system includes: a laser beam generator, a laser beam shaper, a spatial light modulator, imaging optics and an image positioner. The laser beam generator generates a laser beam, which is shaped by the laser beam shaper to modify the laser beam to an optimized beam profile. The shaped laser beam is modulated by the spatial light modulator, which generates, at a place removed from the substrate surface, an optical pattern. The imaging optics causes the optical pattern to be imaged on the substrate surface. An image positioner allows for the optical pattern to be positioned to different areas of the substrate surface. The system can produce adapted optically variable devices, optically variable media, dot matrix holograms or embossing substrates | 09-11-2008 |
20110011839 | Method and apparatus for laser micromachining a conical surface - Embodiments of the present invention are directed to methods and systems for micromachining a conical surface. In one embodiment, such a system may include a rotating platform for receiving a long line of laser illumination, a mask having a predetermined pattern comprising a sector of a planar ring, the mask being positioned on the rotating platform, a workpiece stage having a rotational axis for rotating a removably-affixed workpiece comprising a conical surface, wherein the sector comprises the planar image of the conical surface, an excimer laser for producing a laser beam, a homogenizer for homogenizing the laser beam in at least a single direction, at least one condenser lens, a turning mirror and at least one projection lens. | 01-20-2011 |
20120000893 | Precision Laser Ablation - Methods and systems for precisely removing selected layers of materials from a multi-layer work piece using laser ablation are disclosed. Precise removal of one or more selected layers of materials of a work piece may be performed by irradiating at least one location on a multi-layer work piece with a laser beam, ablating material at the at least one location, detecting one or more characteristics of the material ablated at the at least one location and analyzing the one or more characteristics to identify a change in at least one of the one or more characteristics that indicates a change in the type of material being ablated. Related systems are also described. | 01-05-2012 |
20130193618 | Laser Machining System and Method for Machining Three-Dimensional Objects from a Plurality of Directions - Embodiments of the present disclosure are directed to systems ( | 08-01-2013 |
Patent application number | Description | Published |
20080224032 | Micromachined field asymmetric ion mobility filter and detection system - A micromechanical field asymmetric ion mobility filter for a detection system includes a pair of spaced substrates defining between them a flow path between a sample inlet and an outlet; an ion filter disposed in the path and including a pair of spaced filter electrodes, one electrode associated with each substrate; and an electrical controller for applying a bias voltage and an asymmetric periodic voltage across the ion filter electrodes for controlling the paths of ions through the filter. | 09-18-2008 |
20090045331 | Solid-state flow generator and related systems, applications, and methods - The invention, in various embodiments, is directed to a method for analyzing a sample using a solid-state flow generator that provides a flow of effluent including the sample through an ion mobility based filter. | 02-19-2009 |
20090189064 | ULTRA COMPACT ION MOBILITY BASED ANALYZER APPARATUS, METHOD, AND SYSTEM - An ultra compact ion mobility based analyzer in a multilayered chip assembly employing various features such as a ion flow generator to propel ions through an ion mobility based filter and, thereby, reduce analyzer size, cost, and power requirements. | 07-30-2009 |
20100282961 | Differential mobility spectrometer pre-filter assembly for a mass spectrometer - A pre-filter assembly including a differential mobility spectrometer (DMS) that is configured to be in-line with a mass spectrometer (MS) such that the MS continuously receives carrier flow from the DMS when the DMS filtering fields are removed. | 11-11-2010 |
20110042561 | METHODS AND APPARATUS FOR ENHANCED ION BASED SAMPLE DETECTION USING SELECTIVE PRE-SEPARATION AND AMPLIFICATON - The invention relates generally to ion mobility based systems, methods and devices for analyzing samples and, more particularly, to sample pre-separation and amplification. | 02-24-2011 |
20110101214 | COUPLING DIFFERENTIAL MOBILITY BASED AMBIENT PRESSURE ION PREFILTERING AND ION FOCUSING AT LOW FLOW RATES FOR A PORTABLE MASS SPECTROMETER - A sample analysis apparatus and system including an ion inlet, an ion detector and an ion focusing assembly for converging a plurality of ion streams from the ion inlet into at least one focused ion stream. | 05-05-2011 |
20110133076 | TANDEM DIFFERENTIAL MOBILITY SPECTROMETERS AND MASS SPECTROMETER FOR ENHANCED ANALYSIS - The invention relates generally to systems, methods and devices for analyzing samples and, more particularly, to systems using a differential mobility spectrometer in combination with a mass analyzer to enhance the analysis process of constituents of a sample. | 06-09-2011 |
20120025070 | METHOD AND APPARATUS FOR ENHANCED ION MOBILITY BASED SAMPLE ANALYSIS USING VARIOUS ANALYZER CONFIGURATIONS - A ion mobility-based analyzer system including a first ion mobility-based filter for passing selected ions through a time-varying field where the time-varying field being compensated by an adjustable compensation setting. The analyzer also includes a second ion mobility-based filter for receiving a first portion of ions from the first ion mobility-based filter. The second ion mobility-based filter includes a voltage gradient for separating ions of the first portion of ions where the ions have associated retention times based on their times of flight through the voltage gradient. The second ion mobility-based filter includes a detector for detecting the ions at their retention times. The analyzer system further includes a display that displays the detected ions in a plot relating the retention times of the ions in the second ion mobility-based filter with compensation settings of the first ion mobility-based filter. | 02-02-2012 |
20120160997 | Non-radioactive ion sources with ion flow control - An ion-based analyzer including a non-radioactive ion source, an ion generation chamber for generating ions, a sample ionization chamber and a controller for employing ion flow control, an ion-based filter, and a detector for analyzing a sample. | 06-28-2012 |
Patent application number | Description | Published |
20080226557 | Luciferins - Novel luciferins, methods of making luciferins, and uses of the same are disclosed. | 09-18-2008 |
20080233609 | Spirolactam Targeting Compounds and Related Compounds - Spirolactam targeting compounds, related compounds, uses of such compounds, and methods of making such compounds are disclosed. | 09-25-2008 |
20080299592 | Red-Shifted Luciferase - The compositions described herein shift the light output of luciferases to the near-IR by resonance energy transfer to a targetable near-IR fluorophore. | 12-04-2008 |
20100297684 | ACTIVATIBLE DYES - Novel, activatable dyes, such as photoactivatable dyes, e.g., oxazine dyes, are described. Some of the dyes are targeting dyes that can, e.g., target biomolecules, such as polypeptides, proteins, or nucleic acids. Upon activation, such as by irradiation, the novel dyes rapidly turn on their fluorescence and emit light, such as near-IR light with spatial and temporal precision. | 11-25-2010 |
20110136156 | LUCIFERINS - Novel luciferins, methods of making luciferins, and uses of the same are disclosed. | 06-09-2011 |
20120276564 | Luciferins - Novel luciferins, methods of making luciferins, and uses of the same are disclosed. | 11-01-2012 |
20140193340 | Luciferin Amides - This disclosure relates to luciferin amides of formula (I) shown below: | 07-10-2014 |
20140201855 | MUTANT LUCIFERASES - Described are mutant luciferases, nucleic acids that encode them, cells and animals expressing them, methods of use thereof, and kits. | 07-17-2014 |
20140275526 | SULFONATE COMPOUNDS - This disclosure relates to compounds containing a fluorophore covalently bonded to at least one protected sulfonate group of formula (I): | 09-18-2014 |
Patent application number | Description | Published |
20080216602 | COATING PROCESS FOR MANUFACTURE OR REPROCESSING OF SPUTTER TARGETS AND X-RAY ANODES - Disclosed is a process for the reprocessing or production of a sputter target or an X-ray anode wherein a gas flow forms a gas/powder mixture with a powder of a material chosen from the group consisting of niobium, tantalum, tungsten, molybdenum, titanium, zirconium, mixtures of two or more thereof and alloys thereof with at least two thereof or with other metals, the powder has a particle size of 0.5 to 150 μm, wherein a supersonic speed is imparted to the gas flow and the jet of supersonic speed is directed on to the surface of the object to be reprocessed or produced. | 09-11-2008 |
20080271779 | Fine Grained, Non Banded, Refractory Metal Sputtering Targets with a Uniformly Random Crystallographic Orientation, Method for Making Such Film, and Thin Film Based Devices and Products Made Therefrom - The invention relates to a sputtering target which has a fine uniform equiaxed grain structure of less than 44 microns, no preferred texture orientation as measured by electron back scattered diffraction (“EBSD”) and that displays no grain size banding or texture banding throughout the body of the target. The invention relates a sputtering target with a lenticular or flattened grain structure, no preferred texture orientation as measured by EBSD and that displays no grain size or texture banding throughout the body of the target and where the target has a layered structure incorporating a layer of the sputtering material and at least one additional layer at the backing plate interface, said layer has a coefficient of thermal expansion (“CTE”) value between the CTE of the backing plate and the CTE of the layer of sputtering material. The invention also relates to thin films and their use of using the sputtering target and other applications, such as coatings, solar devices, semiconductor devices etc. The invention further relates to a process to repair or rejuvenate a sputtering target. | 11-06-2008 |
20080314737 | Methods of Making Molybdenium Titanium Sputtering Plates and Targets - Molybdenum titanium sputter targets are provided. In one aspect, the targets are substantially free of the β(Ti, Mo) alloy phase. In another aspect, the targets are substantially comprised of single phase β(Ti, Mo) alloy. In both aspects, particulate emission during sputtering is reduced. Methods of preparing the targets, methods of bonding targets together to produce large area sputter targets, and films produced by the targets, are also provided. | 12-25-2008 |
20100015467 | METHOD FOR COATING A SUBSTRATE AND COATED PRODUCT - Disclosed is a method of applying coatings to surfaces, wherein a gas flow forms a gas-powder mixture with a powder of a material selected from the group consisting of niobium, tantalum, tungsten, molybdenum, titanium, zirconium, nickel, cobalt, iron, chromium, aluminum, silver, copper, mixtures of at least two thereof or their alloys with at least two thereof or with other metals, the powder has a particle size of from 0.5 to 150 μm, an oxygen content of less than 500 ppm oxygen and a hydrogen content of less than 500 ppm, wherein a supersonic speed is imparted to the gas flow and the jet of supersonic speed is directed onto the surface of an object. The coatings prepared are used, for example, as corrosion protection coatings. | 01-21-2010 |
20100061876 | DYNAMIC DEHYDRIDING OF REFRACTORY METAL POWDERS - Refractory metal powders are dehydrided in a device which includes a preheat chamber for retaining the metal powder fully heated in a hot zone to allow diffusion of hydrogen out of the powder. The powder is cooled in a cooling chamber for a residence time sufficiently short to prevent re-absorbtion of the hydrogen by the powder. The powder is consolidated by impact on a substrate at the exit of the cooling chamber to build a deposit in solid dense form on the substrate. | 03-11-2010 |
20100086800 | METHOD OF MANUFACTURING BULK METALLIC STRUCTURES WITH SUBMICRON GRAIN SIZES AND STRUCTURES MADE WITH SUCH METHOD - Three dimensionally large metallic structures comprised of submicron grain sizes are produced by a process which includes directing a supersonic powder jet against a substrate such that the powder adheres to the substrate and to itself to form a dense cohesive deposit. The powder jet may be comprised of refractory metal powders. The powder may be deposited by a supersonic jet and may be extruded by Equi channel angular extrusion. | 04-08-2010 |
20100272889 | PROCESS FOR PREPARING METAL POWDERS HAVING LOW OXYGEN CONTENT, POWDERS SO-PRODUCED AND USES THEREOF - The present invention is directed to a process for the preparation of a metal powder having a purity at least as high as the starting powder and having an oxygen content of 10 ppm or less comprising heating said metal powder containing oxygen in the form of an oxide, with the total oxygen content being from 50 to 3000 ppmf in an inert atmosphere at a pressure of from 1 bar to 10 | 10-28-2010 |
20110132534 | METHODS OF JOINING PROTECTIVE METAL-CLAD STRUCTURES HAVING LOW ATTENDANT ENERGY CONSUMPTION - The present invention is directed to a process for joining tantalum clad steel structures. The process broadly comprises:
| 06-09-2011 |
20110300396 | PROTECTIVE METAL-CLAD STRUCTURES - In various embodiments, a metallic structure includes first and second clad structures each comprising a protective layer disposed over a steel layer, a joint joining the steel layers of first and second clad structures, and, directly connecting the protective layers of the first and second clad structures, a layer of metal powder disposed in contact with (i) the joint, (ii) the protective layers of the first and second clad structures, and (iii) a portion of at least one of the steel layers proximate the joint. | 12-08-2011 |
20110303535 | SPUTTERING TARGETS AND METHODS OF FORMING THE SAME - In various embodiments, sputtering targets incorporate an intermediate plate having a coefficient of thermal expansion (CTE) between a CTE of the backing plate and a CTE of the target material. | 12-15-2011 |
20120145316 | METHODS OF JOINING METALLIC PROTECTIVE LAYERS - In various embodiments, protective layers are bonded to a steel layer and connected by a layer of unmelted metal powder produced by cold spray. | 06-14-2012 |
20120189483 | Methods of forming molybdenum sputtering targets - In various embodiments, tubular sputtering targets are produced by forming a tubular billet at least by pressing molybdenum powder in a mold and sintering the pressed molybdenum powder, working the tubular billet to form a worked billet, and heat treating the worked billet. | 07-26-2012 |
20120251714 | FINE GRAINED, NON BANDED, REFRACTORY METAL SPUTTERING TARGETS WITH A UNIFORMLY RANDOM CRYSTALLOGRAPHIC ORIENTATION, METHOD FOR MAKING SUCH FILM, AND THIN FILM BASED DEVICES AND PRODUCTS MADE THEREFROM - In various embodiments, sputtering targets are refurbished by spray-depositing a powder within a furrow in the sputtering target to form a layer therein. | 10-04-2012 |
20120291592 | PROCESS FOR PREPARING METAL POWDERS HAVING LOW OXYGEN CONTENT, POWDERS SO-PRODUCED AND USES THEREOF - In various embodiments, low-oxygen metal powder is produced by heating a metal powder to a temperature at which an oxide of the metal powder becomes thermodynamically unstable and applying a pressure to volatilize the oxygen. | 11-22-2012 |
20120315387 | DYNAMIC DEHYDRIDING OF REFRACTORY METAL POWDERS - Refractory metal powders are dehydrided in a device which includes a preheat chamber for retaining the metal powder fully heated in a hot zone to allow diffusion of hydrogen out of the powder. The powder is cooled in a cooling chamber for a residence time sufficiently short to prevent re-absorbtion of the hydrogen by the powder. The powder is consolidated by impact on a substrate at the exit of the cooling chamber to build a deposit in solid dense form on the substrate. | 12-13-2012 |
20130156967 | SPRAY REJUVENATION OF SPUTTERING TARGETS - In various embodiments, used sputtering targets are refurbished at least in part by maintaining a large obliquity angle between the spray-deposition gun and the depressed surface contour of the target during spray deposition of the target material. | 06-20-2013 |
20130224059 | METHODS OF FORMING MOLYBDENUM SPUTTERING TARGETS - In various embodiments, planar sputtering targets are produced by forming a billet at least by pressing molybdenum powder in a mold and sintering the pressed powder, working the billet to form a worked billet, heat treating the worked billet, working the worked billet to form a final billet, and heat treating the final billet. | 08-29-2013 |
20130264013 | METHODS OF JOINING METALLIC PROTECTIVE LAYERS - In various embodiments, protective layers are bonded to a steel layer and connected by a layer of unmelted metal powder produced by cold spray. | 10-10-2013 |
20130302519 | DYNAMIC DEHYDRIDING OF REFRACTORY METAL POWDERS - Refractory metal powders are dehydrided in a device which includes a preheat chamber for retaining the metal powder fully heated in a hot zone to allow diffusion of hydrogen out of the powder. The powder is cooled in a cooling chamber for a residence time sufficiently short to prevent re-absorption of the hydrogen by the powder. The powder is consolidated by impact on a substrate at the exit of the cooling chamber to build a deposit in solid dense form on the substrate. | 11-14-2013 |
20130337159 | METHODS OF REJUVENATING SPUTTERING TARGETS - In various embodiments, a sputtering target initially formed by ingot metallurgy or powder metallurgy and comprising a sputtering-target material is provided, the sputtering-target material (i) comprising a metal, (ii) defining a recessed furrow therein, and (iii) having a first grain size and a first crystalline microstructure. A powder is spray-deposited within the furrow to form a layer therein, the layer (i) comprising the metal, (ii) having a second grain size finer than the first grain size, and (iii) having a second crystalline microstructure more random than the first crystalline microstructure. Spray-depositing the powder within the furrow forms a distinct boundary line between the layer and the sputtering-target material. | 12-19-2013 |
20140299466 | HIGH-DENSITY METALLIC SPUTTERING TARGETS - The present invention is directed to a process for producing high density, refractory metal products via a press/sintering process. The invention is also directed to a process for producing a sputtering target and to the sputtering target so produced. | 10-09-2014 |
20140311669 | METHODS OF JOINING METALLIC PROTECTIVE LAYERS - In various embodiments, protective layers are bonded to a steel layer, overlapped, and at least partially covered by a layer of unmelted metal powder produced by cold spray. | 10-23-2014 |
20150034477 | FINE GRAINED, NON BANDED, REFRACTORY METAL SPUTTERING TARGETS WITH A UNIFORMLY RANDOM CRYSTALLOGRAPHIC ORIENTATION, METHOD FOR MAKING SUCH FILM, AND THIN FILM BASED DEVICES AND PRODUCTS MADE THEREFROM - In various embodiments, a sputtering target initially formed by ingot metallurgy or powder metallurgy and rejuvenated by, e.g., cold spray, is utilized in sputtering processes to produce metallic thin films. | 02-05-2015 |
Patent application number | Description | Published |
20090001890 | Apparatus for Plasma Processing a Substrate and a Method Thereof - An apparatus for processing a substrate includes a pulsed power supply that generates a waveform having a first period with a first power level and a second period with a second power level. A plasma source generates a first plasma during the first period and a second plasma during the second period. The first plasma may have higher plasma density than the second plasma. A bias voltage power supply generates a bias voltage waveform at an output that is electrically connected to a platen which supports a substrate. The bias voltage waveform having a first voltage and a second voltage may be coupled to the substrate. The first voltage may have more negative potential than the second voltage. | 01-01-2009 |
20090017229 | Processing System Platen having a Variable Thermal Conductivity Profile - A platen for a processing system includes a first and a second thermal region that are separated by at least one boundary. A first fluid conduit is positioned in the first thermal region. A second fluid conduit is positioned in the second thermal region. A fluid reservoir having a first output is coupled to the first fluid conduit and a second output that is coupled to the second fluid conduit. The fluid reservoir provides fluid to the first fluid conduit with first fluid conditions that provides a first thermal conductivity to the first thermal region and provides fluid to the second fluid conduit with second fluid conditions that provides a second thermal conductivity to the second thermal region so that a predetermined thermal conductivity profile is achieved in the platen. | 01-15-2009 |
20090084987 | CHARGE NEUTRALIZATION IN A PLASMA PROCESSING APPARATUS - A plasma processing apparatus includes a process chamber, a source configured to generate a plasma in the process chamber, and a platen configured to support a workpiece in the process chamber. The platen is biased with a pulsed platen signal having pulse ON and OFF time periods to accelerate ions from the plasma towards the workpiece during the pulse ON time periods and not the pulse OFF time periods. A plate is positioned in the process chamber. The plate is biased with a plate signal to accelerate ions from the plasma towards the plate to cause an emission of secondary electrons from the plate during at least a portion of one of the pulse OFF time periods of the pulsed platen signal to at least partially neutralize charge accumulation on the workpiece. | 04-02-2009 |
20110124186 | APPARATUS AND METHOD FOR CONTROLLABLY IMPLANTING WORKPIECES - A plasma processing apparatus comprises a plasma source configured to produce a plasma in a plasma chamber, such that the plasma contains ions for implantation into a workpiece. The apparatus also includes a focusing plate arrangement having an aperture arrangement configured to modify a shape of a plasma sheath of the plasma proximate the focusing plate such that ions exiting an aperture of the aperture arrangement define focused ions. The apparatus further includes a processing chamber containing a workpiece spaced from the focusing plate such that a stationary implant region of the focused ions at the workpiece is substantially narrower that the aperture. The apparatus is configured to create a plurality of patterned areas in the workpiece by scanning the workpiece during ion implantation. | 05-26-2011 |
20110186749 | ION SOURCE - An ion source includes an arc chamber having an extraction aperture, and a plasma sheath modulator positioned in the arc chamber. The plasma sheath modulator is configured to control a shape of a boundary between a plasma and a plasma sheath proximate the extraction aperture, wherein the plasma sheath modulator includes a semiconductor. A well focused ion beam having a high current density can be generated by the ion source. A high current density ion beam can improve the throughput of an associated process. The emittance of the ion beam can also be controlled. | 08-04-2011 |
20110223546 | METHOD AND SYSTEM FOR MODIFYING SUBSTRATE RELIEF FEATURES USING ION IMPLANTION - A method of treating resist features comprises positioning, in a process chamber, a substrate having a set of patterned resist features on a first side of the substrate and generating a plasma in the process chamber having a plasma sheath adjacent to the first side of the substrate. The method may further comprise modifying a shape of a boundary between the plasma and the plasma sheath with a plasma sheath modifier so that a portion of the shape of the boundary is not parallel to a plane defined by a front surface of the substrate facing the plasma, wherein ions from the plasma impinge on the patterned resist features over a wide angular range during a first exposure. | 09-15-2011 |
20110309049 | TECHNIQUES FOR PLASMA PROCESSING A SUBSTRATE - Techniques for plasma processing a substrate are disclosed. In one particular exemplary embodiment, the technique may be realized with a method comprising introducing a feed gas proximate to a plasma source, where the feed gas may comprise a first and second species, where the first and second species have different ionization energies; providing a multi-level RF power waveform to the plasma source, where the multi-level RF power waveform has at least a first power level during a first pulse duration and a second power level during a second pulse duration, where the second power level may be different from the first power level; ionizing the first species of the feed gas during the first pulse duration; ionizing the second species during the second pulse duration; and providing a bias to the substrate during the first pulse duration. | 12-22-2011 |
20120021136 | SYSTEM AND METHOD FOR CONTROLLING PLASMA DEPOSITION UNIFORMITY - A plasma process uniformity control apparatus comprises a plasma chamber defined by chamber walls and a plurality of magnetic elements disposed on the outside of the chamber walls. Each of the plurality of magnets is configured to supply a magnetic field directed at respective portions of the plasma inside the chamber to control the uniformity of the plasma directed toward the target substrate. | 01-26-2012 |
20120168640 | SYSTEM AND METHOD FOR GAS LEAK CONTROL IN A SUBSTRATE HOLDER - An electrostatic clamp includes a heating block for heating a substrate, the heating block having a first surface disposed toward the substrate and a second surface opposite the first surface. A base is arranged to adjoin at least a portion of the second surface of the heating block. The adjoined base and heating block may mutually define an inner gap between a first portion of the heating block and the base. An outer gap is arranged concentric with the inner gap between a second portion of the heating block and the base, the inner and outer gaps being isolated from one another by a first sealing surface formed between the second surface of the heating block and the base. | 07-05-2012 |
20120228515 | APPARATUS AND METHOD FOR MASKLESS PATTERNED IMPLANTION - A method of implanting a workpiece in an ion implantation system. The method may include providing an extraction plate adjacent to a plasma chamber containing a plasma, such that the extraction plate extracts ions from the plasma through at least one aperture that provides an ion beam having ions distributed over a range of an angles of incidence on the workpiece. The method may include scanning the workpiece with respect to the extraction plate and varying a power level of the plasma during the scanning from a first power level to a second power level, wherein at a surface of the workpiece, a first beam width at a first power level is greater than a second beam width at a second power level. | 09-13-2012 |
20120248328 | APPARATUS AND METHOD FOR MULTIPLE SLOT ION IMPLANTATION - An ion implantation system may comprise a plasma source for providing a plasma and a workpiece holder arranged to receive a bias with respect to the plasma to attract ions across a plasma sheath toward the substrate. The system may also include an extraction plate arrangement comprising a multiplicity of different apertures each arranged to provide an ion beam having ions distributed over a range of angles of incidence on the workpiece, wherein a first ion beam extracted from a first aperture has a first beam profile that differs from a second ion beam extracted from a second aperture. | 10-04-2012 |
20120258600 | METHOD AND SYSTEM FOR POST-ETCH TREATMENT OF PATTERNED SUBSTRATE FEATURES - A method of patterning a substrate, comprises providing a set of patterned features on the substrate, exposing the set of patterned features to a dose of ions incident on the substrate over multiple angles, and selectively etching exposed portions of the patterned features. | 10-11-2012 |
20130092529 | PLASMA PROCESSING WITH ENHANCED CHARGE NEUTRALIZATION AND PROCESS CONTROL - Plasma processing with enhanced charge neutralization and process control is disclosed. In accordance with one exemplary embodiment, the plasma processing may be achieved as a method of plasma processing a substrate. The method may comprise providing the substrate proximate a plasma source; applying to the plasma source a first RF power level during a first period and a second RF power level during a second period, the first and second RF power levels being greater than zero RF power level, wherein the second RF power level is greater than the first RF power level; generating with the plasma source a first plasma during the first period and a second plasma during the second period; and applying to the substrate a first bias voltage during the first period and a second bias voltage during the second period, wherein the first voltage has more negative potential than the second voltage. | 04-18-2013 |
20130146790 | APPARATUS AND METHOD FOR CHARGE NEUTRALIZATION DURING PROCESSING OF A WORKPIECE - A processing system may include a plasma source for providing a plasma and a workpiece holder arranged to receive ions from the plasma. The processing system may further include a pulsed bias circuit electrically coupled to the plasma source and operable to switch a bias voltage supplied to the plasma source between a high voltage state in which the plasma source is biased positively with respect to ground and a low voltage state in which the plasma source is biased negatively with respect to the ground. | 06-13-2013 |
20130234034 | APPARATUS AND METHOD FOR CONTROLLABLY IMPLANTING WORKPIECES - A plasma processing apparatus comprises a plasma source configured to produce a plasma in a plasma chamber, such that the plasma contains ions for implantation into a workpiece. The apparatus also includes a focusing plate arrangement having an aperture arrangement configured to modify a shape of a plasma sheath of the plasma proximate the focusing plate such that ions exiting an aperture of the aperture arrangement define focused ions. The apparatus further includes a processing chamber containing a workpiece spaced from the focusing plate such that a stationary implant region of the focused ions at the workpiece is substantially narrower that the aperture. The apparatus is configured to create a plurality of patterned areas in the workpiece by scanning the workpiece during ion implantation. | 09-12-2013 |
20130287963 | Plasma Potential Modulated ION Implantation Apparatus - An ion implantation apparatus including a first plasma chamber, a second plasma chamber and an extraction electrode disposed therebetween. The first and second plasma chambers configured to house respective plasmas in response to the introduction of a different feed gases therein. The extraction electrode is electrically isolated from the plasma chamber. An extraction voltage is applied to the first plasma chamber above a bias potential used to generate the plasma therein. The extraction voltage drives the plasma potential to accelerate the ions in the first plasma to a desired implant energy. The accelerated ions pass through an aperture in the extraction electrode and are directed toward a substrate housed within the second plasma chamber for implantation. | 10-31-2013 |
20140306127 | METHOD AND SYSTEM FOR MODIFYING SUBSTRATE RELIEF FEATURES USING ION IMPLANTATION - A method of treating resist features comprises positioning, in a process chamber, a substrate having a set of patterned resist features on a first side of the substrate and generating a plasma in the process chamber having a plasma sheath adjacent to the first side of the substrate. The method may further comprise modifying a shape of a boundary between the plasma and the plasma sheath with a plasma sheath modifier so that a portion of the shape of the boundary is not parallel to a plane defined by a front surface of the substrate facing the plasma, wherein ions from the plasma impinge on the patterned resist features over a wide angular range during a first exposure. | 10-16-2014 |
20140356547 | SYSTEM AND METHOD OF IMPROVING IMPLANT QUALITY IN A PLASMA-BASED IMPLANT SYSTEM - A system and method for the removal of deposited material from the walls of a plasma chamber is disclosed. The system may have two modes; a normal operating mode and a cleaning mode. | 12-04-2014 |
20150024579 | Method Of Improving Ion Beam Quality In An Implant System - A method for improving the ion beam quality in an ion implanter is disclosed. In some ion implantation systems, contaminants from the ion source are extracted with the desired ions, introducing contaminants to the workpiece. These contaminants may be impurities in the ion source chamber. This problem is exacerbated when mass analysis of the extracted ion beam is not performed, and is further exaggerated when the desired feedgas includes a halogen. | 01-22-2015 |
20150024580 | Method For Implant Productivity Enhancement - A method of processing a workpiece is disclosed, where the ion chamber is first coated with the desired dopant species and another species. Following this conditioning process, a feedgas, which comprises fluorine and the desired dopant, is introduced to the chamber and ionized. Ions are then extracted from the chamber and accelerated toward the workpiece, where they are implanted without being first mass analyzed. The other species used during the conditioning process may be a Group 3, 4 or 5 element. The desired dopant species may be boron. | 01-22-2015 |