Underhill
D. Alan Underhill, Edmonton CA
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20130178515 | PREDICTIVE MARKERS FOR TAXANE RESPONSIVENESS AND METHODS OF USE THEREOF - Taxanes are widely used in the treatment of breast cancer, although there are currently no validated predictive markers for taxane responsiveness. While the mechanism by which taxanes induce mitotic arrest is well documented, the signaling pathway that links mitotic arrest to cell death, is ill-defined. As described herein, the BH3-only protein Bad and Bik are prognostic indicators for overall survival after adjuvant taxane chemotherapy and a predictive marker for taxane responsiveness. | 07-11-2013 |
Gary Underhill, Moncton CA
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20100200105 | NOZZLE FOR USE IN A NON-OVERFLOW LIQUID DELIVERY SYSTEM - A nozzle for use in a non-overflow liquid delivery system comprises a nozzle body, a liquid delivery conduit having a liquid-receiving inlet and a liquid-dispensing outlet, and a non-bifurcated liquid recovery conduit having a liquid-receiving inlet and a liquid-conveying outlet. The minimum effective internal cross-sectional area of the liquid recovery throughpassage is greater than half the minimum effective internal cross-sectional area of the liquid delivery throughpassage. A valve has a first movable valve portion and a second movable valve portion that are interconnected one to the other for co-operative movement one with the other. A manually operable trigger is connected to the first movable valve portion for corresponding positive uninterruptable movement of the first movable valve portion between a valve-closed configuration and the valve-open configuration. | 08-12-2010 |
20100200106 | AUTOMATIC SHUT-OFF NOZZLE FOR USE IN A NON-OVERFLOW LIQUID DELIVERY SYSTEM - An automatic shut-off nozzle comprises a liquid delivery conduit and a liquid recovery conduit. A valve has a first movable valve portion movable between a valve closed position whereat liquid is precluded from being dispensed from the liquid-dispensing outlet of the liquid delivery conduit and a valve open position whereat liquid is permitted to be dispensed from the liquid-dispensing outlet of the liquid delivery conduit. A manually operable valve control mechanism is reconfigurable between an operating configuration whereat force can be transmitted from the valve control mechanism to the valve to thereby move the first movable valve portion to the valve open position, and a non-operating configuration whereat force cannot be transmitted from the valve control mechanism to the valve. A liquid sensor has a rest state and an actuated state whereat the liquid sensor reconfigures the manually operable valve control mechanism from the operating configuration to the non-operating configuration. | 08-12-2010 |
20100200111 | NON-OVERFLOW LIQUID DELIVERY SYSTEM - A non-overflow liquid delivery system comprises a pumping apparatus having a liquid delivery pumping portion and a liquid recovery pumping portion fluidically isolated one from the other. A nozzle has a liquid delivery conduit and a liquid recovery conduit. A liquid delivery hose connects the liquid delivery pumping portion of the pumping apparatus in fluid communication with the liquid delivery conduit. A liquid recovery hose connects the liquid recovery pumping portion of the pumping apparatus in fluid communication with the liquid recovery conduit. A valve has a first movable valve portion for opening and closing the liquid delivery conduit. A manually operable valve control mechanism is connected to the valve for controlling the first movable valve portion, and has a liquid sensor responsive to a threshold condition of liquid in the liquid recovery conduit to thereby cause the first movable valve portion to close the liquid delivery conduit. | 08-12-2010 |
20130133779 | NON-OVERFLOW LIQUID DELIVERY SYSTEM - A non-overflow liquid delivery system comprises a pumping apparatus having a liquid delivery pumping portion and a liquid recovery pumping portion fluidically isolated one from the other. A nozzle has a liquid delivery conduit and a liquid recovery conduit. A liquid delivery hose connects the liquid delivery pumping portion of the pumping apparatus in fluid communication with the liquid delivery conduit. A liquid recovery hose connects the liquid recovery pumping portion of the pumping apparatus in fluid communication with the liquid recovery conduit. A valve has a first movable valve portion for opening and closing the liquid delivery conduit. A manually operable valve control mechanism is connected to the valve for controlling the first movable valve portion, and has a liquid sensor responsive to a threshold condition of liquid in the liquid recovery conduit to thereby cause the first movable valve portion to close the liquid delivery conduit. | 05-30-2013 |
20130139926 | NOZZLE FOR USE IN A NON-OVERFLOW LIQUID DELIVERY SYSTEM - A nozzle for use in a non-overflow liquid delivery system comprises a nozzle body, a liquid delivery conduit having a liquid-receiving inlet and a liquid-dispensing outlet, and a non-bifurcated liquid recovery conduit having a liquid-receiving inlet and a liquid-conveying outlet. The minimum effective internal cross-sectional area of the liquid recovery throughpassage is greater than half the minimum effective internal cross-sectional area of the liquid delivery throughpassage. A valve has a first movable valve portion and a second movable valve portion that are interconnected one to the other for co-operative movement one with the other. A manually operable trigger is connected to the first movable valve portion for corresponding positive uninterruptable movement of the first movable valve portion between a valve-closed configuration and the valve-open configuration. | 06-06-2013 |
20130284308 | AUTOMATIC SHUT-OFF NOZZLE FOR USE IN A NON-OVERFLOW LIQUID DELIVERY SYSTEM - An automatic shut-off nozzle comprises a liquid delivery conduit and a liquid recovery conduit. A valve has a first movable valve portion movable between a valve closed position whereat liquid is precluded from being dispensed from the liquid-dispensing outlet of the liquid delivery conduit and a valve open position whereat liquid is permitted to be dispensed from the liquid-dispensing outlet of the liquid delivery conduit. A manually operable valve control mechanism is reconfigurable between an operating configuration whereat force can be transmitted from the valve control mechanism to the valve to thereby move the first movable valve portion to the valve open position, and a non-operating configuration whereat force cannot be transmitted from the valve control mechanism to the valve. A liquid sensor has a rest state and an actuated state whereat the liquid sensor reconfigures the manually operable valve control mechanism from the operating configuration to the non-operating configuration. | 10-31-2013 |
Ian Underhill, Eagle Heights AU
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20140257139 | OPTICAL SENSING DEVICE - The present disclosure provides an optical sensing device that comprises a plurality of optical light guide portions. Each optical light guide portion has a sensing region for sensing a property. The device further comprises a support for supporting the optical light guide portions and for positioning the optical light guide portions in a manner such that at least two sensing regions have a different radial positions around a portion of the support such that the optical device is arranged to sense a property at the different radial positions. | 09-11-2014 |
Ian Underhill, Campbell AU
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20110116743 | OPTICAL DEVICE - The present disclosure provides an optical device comprising a first optical fibre portion having a first region and further regions between which the first region is positioned. The optical device also comprises a second optical fibre portion having a second region and further regions between which the second region is positioned. Further, the optical fibre comprises at least one member to which the first and second optical fibre portions are attached at the first and second regions. The first and second regions are positioned at opposite sides of an area defined between the first and second regions and spaced apart from each other by a first distance and wherein adjacent further regions are spaced apart by a second distance that is smaller than the first distance. | 05-19-2011 |
Ian David Underhill, Queensland AU
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20090307978 | AUTOMATED LOUVRE SYSTEM - A motorised drive system for a louvre assembly of the type containing a surround frame, a pair of spaced apart operating bars positioned within the surround frame and where movement of the operating bars causes rotation of the louvres, the drive system comprising a motor adapted to be positioned within the surround frame, the motor operationally driving a drive shaft which is substantially horizontal when the drive system is fitted within the surround frame, a mounting member which is attached for rotation with the drive shaft, at least two spaced apart attachment points on the mounting member, a first link arm, a second link arm and a third link arm, the first link arm being attached to one of the attachment points and to one said operating bar, the second link arm being attached to another of the attachment points, the third link arm being pivotally attached to the second link arm and to the other operating bar. | 12-17-2009 |
Kimberly Kay Underhill, Surrey GB
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20100072108 | METHOD OF MERCHANDISING DISPOSABLE ABSORBENT PANTS - A method of displaying a package of disposable absorbent pant products includes placing the package in a retail store in the same region of the store that also includes clothing. A package for disposable absorbent pant products includes a pocket and device for hanging the package. The package may include a display window through which a consumer may view the disposable absorbent pant products. | 03-25-2010 |
Michael James Underhill, Surrey GB
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20080315943 | Anti-Jitter Circuits - An anti jitter circuit for reducing time jitter in an input pulse train comprises an integrator, a DC removal circuit and a comparator. The anti jitter circuit also has a feedback loop effective to suppress phase deviation of the output pulse train in response to jitter. | 12-25-2008 |
Ross Underhill, Kingston CA
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20130328555 | PULSED EDDY CURRENT SENSOR FOR PRECISION LIFT-OFF MEASUREMENT - There is described a pulsed eddy current sensor for measurement of a lift-off distance over a surface of a metallic substrate (a metallic surface). The pulsed eddy current sensor comprises: a primary excitation coil to which are applied voltage pulses for generating primary magnetic fields, wherein an interaction of the primary magnetic fields with the metallic substrate produces secondary magnetic fields; and secondary pick-up probes, each of the secondary pick-up probes located at a different vertical distance from the metallic surface, the secondary pick-up probes used for measuring the primary and secondary magnetic fields and for producing a differential signal that is representative of the lift-off distance. | 12-12-2013 |
T. Michael Underhill, Vancouver CA
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20110236461 | METHODS FOR STIMULATING CHONDROGENESIS UTILIZING A POTASSIUM CHANNEL INHIBITOR - The invention is directed to a method for stimulating chondrogenesis comprising administering to a subject in need thereof a composition comprising a therapeutically effective amount of a potassium channel inhibitor. | 09-29-2011 |
Tully Michael Underhill, London CA
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20100003307 | COMPOSITION AND USE OF RAR ANTAGONISTS FOR PROMOTING CHONDROGENESIS - The invention provides compositions comprising a RAR antagonist for promoting chondrogenesis and to methods employing such compositions for treating cartilage and associated bone abnormalities resulting from injury or disease and for ex vivo tissue engineering. | 01-07-2010 |
William Roy Underhill, Toronto CA
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20090164565 | REDUNDANT SYSTEMS MANAGEMENT FRAMEWORKS FOR NETWORK ENVIRONMENTS - A redundant systems management framework and method for managing a target system includes an active agent configured to receive instructions from an active central server to perform management tasks on the target system and a plurality of meta-agents provided on the target system. Each meta-agent is an endpoint on the target system and is configured to monitor a corresponding central server, and to reassign the active agent to another central server upon failure of the active central server. The central servers may also monitor each other for proper operation. Each meta-agent also is configured to monitor the active agent and to revive or restart the active agent upon detecting a failure of the active agent. | 06-25-2009 |