Leen
Ann M. Leen, Houston, TX US
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20150017723 | PROCESS OF EXPANDING T CELLS - The present disclosure relates to a novel process for expanding T cells, such as autologous T cells, cell populations therefrom, pharmaceutical compositions comprising the said cell populations and use of the cells and compositions for treatment, particular the treatment or prophylaxis of virus infection and/or cancer, for example in immune compromised or immune competent human patients. | 01-15-2015 |
Ann Marie Leen, Bellaire, TX US
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20140050709 | REVERSING THE EFFECTS OF THE TUMOR MICROENVIRONMENT USING CHIMERIC CYTOKINE RECEPTORS - Disclosed are compositions and methods related to rendering ineffective Th1 T cells resistant to the inhibitory cytokine milieu present in a cancer microenvironment. Tumor-specific T cells are modified to employ a chimeric receptor that binds inhibitory/suppressive cytokines and converts their intracellular consequences to a Th1 immunostimulatory/activating signal. The T cells employ a chimeric antigen receptor having exodomains for IL10, IL13 and/or IL4 fused with the signal transducing endodomains for IL2 and/or IL7. | 02-20-2014 |
Edward Lam Shang Leen, Beaconsfield GB
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20120253190 | CONTRAST-ENHANCED ULTRASOUND ASSESSMENT OF LIVER BLOOD FLOW FOR MONITORING LIVER THERAPY - A method for assessing a liver includes acquiring image information including contrast-enhanced ultrasound images of the liver. A location of the main hepatic artery (MHA) and a location of the main portal vein (MPV) of the liver are identified in at least one of the contrast-enhanced ultrasound images of the liver. Time-intensity information corresponding to perfusion of a contrast agent in the MHA and the MPV is obtained. A biomarker index value (BW) which is a function of the time-intensity information corresponding to the perfusion of contrast agent in the MHA and the time-intensity information corresponding to the perfusion of contrast agent in the MPV is determined. | 10-04-2012 |
Fergus A Leen, Wimbledon Park GB
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20080234037 | System and Logic for Establishing a Wager for a Game - In a particular embodiment of the present invention, a system for establishing a wager associated with a game comprises a processor that receives information about a wager offer, wherein the wager offer is associated with an online game. The processor also receives information about a wager acceptance. The wager offer and the wager acceptance combine to form a wager, wherein the wager is associated with at least one wager parameter. The system further comprises a memory communicatively coupled to the processor and that stores information associated with the at least one wager parameter. | 09-25-2008 |
20100197410 | SYSTEM AND METHOD FOR PROVIDING ENHANCED SERVICES TO A USER OF A GAMING APPLICATION - A system for providing enhanced services to users of a gaming application comprises a server and a platform remotely coupled to the server. The server executes a gaming application. The platform receives a request for enhanced services, and establishes an enhanced services session with a user of the gaming application in response to the request for enhanced services. The enhanced services session corresponds in time at least in part with the execution of the gaming application. The platform further provides enhanced services to the user of the gaming application during the enhanced services session. | 08-05-2010 |
20120135798 | SYSTEM AND LOGIC FOR ESTABLISHING A WAGER FOR A GAME - In a particular embodiment of the present invention, a system for establishing a wager associated with a game comprises a processor that receives information about a wager offer, wherein the wager offer is associated with an online game. The processor also receives information about a wager acceptance. The wager offer and the wager acceptance combine to form a wager, wherein the wager is associated with at least one wager parameter. The system further comprises a memory communicatively coupled to the processor and that stores information associated with the at least one wager parameter. | 05-31-2012 |
20120252546 | SYSTEM AND METHOD FOR ADDING A SKILL ASPECT TO GAMES OF CHANCE - In various embodiments, a predetermined number of move numbers for one or more players or users of a game or application may be determined, e.g., using an indicator. For example, a first group of move numbers for a first player and a second group of move numbers for a second player may be determined. The players use the pre-established move numbers to advance according to the rules of the application or game. Move numbers within a group may be sequenced or non-sequenced. Move numbers may be replaced at each player's turn or when all or a subset of move numbers of a group are used. Move numbers may be established by any type of indicator such as dice, dominos, or a random number generator. In some embodiments, move numbers may be traded in. Move numbers may or may not be visible at predetermined times to one or more players. | 10-04-2012 |
20130017890 | SYSTEM AND METHOD FOR PROVIDING ENHANCED SERVICES TO A USER OF A GAMING APPLICATION - A system for providing enhanced services to users of a gaming application comprises a server and a platform remotely coupled to the server. The server executes a gaming application. The platform receives a request for enhanced services, and establishes an enhanced services session with a user of the gaming application in response to the request for enhanced services. The enhanced services session corresponds in time at least in part with the execution of the gaming application. The platform further provides enhanced services to the user of the gaming application during the enhanced services session. | 01-17-2013 |
20140179405 | SYSTEM AND METHOD FOR ADDING A SKILL ASPECT TO GAMES OF CHANCE - A system and methods are provided in which a certain level of the chance aspect of a game or other application is removed and a certain level of a skill aspect is added. This may be accomplished by using an indicator to establish a predetermined number of move numbers for one or more players in the game. For example, the indicator may be used to determine a first group of move numbers for a first player and a second group of move numbers for a second player. The players use the pre-established move numbers to advance according to the rules of the game. Depending on the particular embodiment, the move numbers within a group may be sequenced or non-sequenced. Move numbers may be replaced at each player's turn or when all or a subset of the move numbers of a group are used. Move numbers may be established by any type of indicator such as dice, dominos, or a random number generator. In some embodiments, move numbers may be traded in. Move numbers may or may not be visible at predetermined times to one or more players. | 06-26-2014 |
20150024832 | METHOD FOR ESTABLISHING A WAGER FOR A GAME - In a particular embodiment of the invention, a system for establishing a wager associated with a game comprises a processor that receives information about a wager offer, wherein the wager offer is associated with an online game. The processor also receives information about a wager acceptance. The wager offer and the wager acceptance combine to form a wager, wherein the wager is associated with at least one wager parameter. The system further comprises a memory communicatively coupled to the processor and that stores information associated with the at least one wager parameter. | 01-22-2015 |
Gabriel Leen, Cork IE
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20130153677 | LIQUID DROPLET DISPENSER - An apparatus for dispensing droplets comprises a dispensing tip with an orifice having a cross sectional area in the range of 0.00002 mm2 to 0.03 mm2. An actuator assembly comprising an actuator element engages with and disengage from the tip and, when engaged, couples acoustic energy to liquid in the tip to expel the liquid through the orifice as a droplet. The actuator assembly includes one or more piezo elements, which may be in the form of piezo stacks. In some embodiments, the actuator assembly comprises a plurality of jaws adapted to move to engage with the dispensing tip for dispensing. This allows side loading of the tip followed by movement of the actuator assembly to engage the tip. | 06-20-2013 |
20150077736 | SENSOR FOR COMBINED TEMPERATURE, PRESSURE, AND REFRACTIVE INDEX DETECTION | 03-19-2015 |
Gabriel Leen, Limerick IE
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20110190640 | Pressure sensor with an interferometric sensor and an in-fiber Bragg grating reference sensor - A pressure sensor ( | 08-04-2011 |
Gabriel Leen, County Cork IE
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20130085355 | MONITORING SYSTEM - A system and method for non-invasive monitoring of cardiac activity in a human or animal is disclosed. A radiation source directs radiation through a patient site, and a detector detects radiation after passing through a patient tissue. A processor processes data derived from the detected radiation, determining pulse peaks and troughs and calculating area under a pulse peak to provide a real time cardiac output indicator. The radiation wavelength is on a haemoglobin spectral isosbestic point, not influenced by changes in SpO2 concentration. The processor performs numerical integration of pulse data between troughs, and wherein said integration is performed per pulse. Preferably, the processor monitors trends, thus providing very useful information and reducing need for calibration. | 04-04-2013 |
J. Brian Leen, Sunnyvale, CA US
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20140319352 | LONG-PATH INFRARED SPECTROMETER - A tunable mid-infrared laser operated in a pulsed mode is coupled off-axis into a high-finesse optical cavity to produce a long-path spectrometer. The cavity receives a gas sample. Laser pulses may be wavelength-scanned by stepping an external grating, allowing the grating to mechanically settle, then measuring the ring-down with a set of laser pulses, before moving on the next wavelength. A detector receiving infrared light exiting the cavity supplies a cavity ring-down trace representative of sample absorption of the infrared pulses. A processor determines an absolute absorption spectrum of the gas sample from the ring-down trace and analyzes sample gas composition and trace concentration from that spectrum. The absorption baseline is highly reproducible and stable, improving the accuracy of multivariate fits, and the spectral resolution can be better than 0.001 cm | 10-30-2014 |
John M. Leen, Seattle, WA US
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20090165110 | DELEGATION IN LOGIC-BASED ACCESS CONTROL - Access to a resource may be controlled by a policy, such that a request to access the resource is either granted or denied based on what assertions have been made by various principals. To find the assertions that support a grant of access to the resource, a template may be created that defines the nature of assertions that would cause access to succeed. Assertions may be stored in the form of tokens. The template may be used to search an existing token store to find assertions that have been made, and/or to generate assertions that have not been found in the token store and that would satisfy the template. The assertions in the template may be created by performing an abductive reasoning process on an access query. | 06-25-2009 |
20090193493 | ACCESS POLICY ANALYSIS - Software tools assist an access-policy analyst or creator to debug and/or author access policies. An access request contains a query that evaluates to either true or false depending on whether access is to be allowed. Abduction may be used to generate assumptions that, if true, would cause the access request to be true. The tool may perform analysis on the generated assumptions, such as: comparing the assumptions with tokens to detect errors in the tokens or to suggest changes to the tokens that would cause the query to be satisfied, or comparing the assumptions to a meta-policy. The tool may allow an analysis, policy author, or other person to interactively walk through assumptions in order to see the implications of the access policy. | 07-30-2009 |
Monte A. Leen, Bellevue, WA US
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20100149824 | WORKLIGHT WITH A HANDS-FREE MOUNTING SYSTEM - A worklight with head mounted on a stand that uses a hands-free mounting apparatus that enables the lamp head to be tilted in different fixed angles without manually loosening and tightening knobs and nuts. The mounting system includes at least one nut body mounted or attached on the surface of the lamp head. The nut body includes a post with a threaded bore surrounded by a plurality of radially aligned beveled ribs. The ribs aligned parallel to the nut's longitudinally axis and are equally spaced apart thereby forming a plurality of slots surrounding the post. The post is slightly shorter than the surrounding ribs. In the preferred embodiment, slots on one side of the nut body are aligned with slots located on the opposite side of the nut body. The stand includes at least one support arm with a straight portion. The outside surface of the straight portion has a diameter sufficient so that the inside surface of the straight portion rests in the two slots located on opposite sides of the nut body. The outer edges of the support arm are pressed inside by springs against the outer surfaces of the ribs. | 06-17-2010 |
Richard Leen, Dessel BE
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20140102339 | PALLET - A pallet having a top deck ( | 04-17-2014 |
Steven Leen, Cumberland Center, ME US
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20130337945 | Variable Gravity Training Device - A variable gravity training device allows a user to train skills in controlling a sports device. The training device has a stationary base, a movable support bar, and a sports device, for example, a ball, a badminton birdie, or a volley ball affixed to the end of the bar. The support bar is weighted, so that the amount of force required to move the sports device is reduced. The weighted bar also reduces the speed with which the sports device returns to its home position. The force adjustment means is adjustable, so that, with training, weights may be removed, so that the conditions governing the sports device correspond to real playing conditions. | 12-19-2013 |
Thomas Leen, Raleigh, NC US
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20100313403 | METHOD AND SYSTEM FOR REPLACING THE WATER COOLED LASER IN A MICROPLATE READER - The present invention relates to a method of refurbishing a microplate reader such as a FLIPR type microplate reader by the replacement of the water cooled laser with an LED source which provides a relatively homogeneous light and operating performance comparable to the laser light source. | 12-16-2010 |
20100319177 | METHOD AND SYSTEM FOR REPLACING THE WATER COOLED LASER IN A MICROPLATE READER - The present invention relates to a method and system for repairing and refurbishing a microplate reader of the Flipr type which has a water cooled argon laser light source. The old laser is removed and replaced with a high power (300 to 500 mW) air cooled solid state laser as a replacement place on its own support and focused and wired to replace the old laser. The new product operates at lower power consumption yet provides accurate measurements. | 12-23-2010 |
20130232771 | METHOD AND SYSTEM FOR REPLACING THE WATER COOLED LASER IN A MICROPLATE READER - The present invention relates to a method and system for repairing and refurbishing a microplate reader of the Flipr type which has a water cooled argon laser light source. The old laser is removed and replaced with a high power (300 to 500 mW) air cooled solid state laser as a replacement place on its own support and focused and wired to replace the old laser. The new product operates at lower power consumption yet provides accurate measurements. | 09-12-2013 |