Patent application number | Description | Published |
20100087358 | NOTCH mutations leading to increased receptor signaling - The present invention is based upon the identification of regions within the NOTCH-1 receptor that, when mutated, lead to increase receptor signaling. The mutations are associated with uncontrolled cellular growth and this growth may be arrested using agents that interfere with NOTCH-1 activity, such as inhibitors of gamma-secretase. Assays for the NOTCH-1 mutations may be used diagnostically or as part of a treatment regimen for cancer patients. | 04-08-2010 |
20100093684 | SYNERGISTIC INTERACTION OF NOTCH-1 INHIBITORS WITH GLUCOCORTICOIDS - The present invention relates to methods and compositions for preventing and/or treating various conditions in a patient, including for example, T-cell lymphoblastic leukemia and lymphoma as well as neurodegenerative diseases, such as for example, Alzheimer's disease. In one preferred embodiment of the invention, such methods include providing a patient with an effective amount of a combination of a NOTCH-1 inhibitor and glucocorticoid. The present invention further encompasses methods for increasing the efficacy of, and mitigating resistance to, glucocorticoids in the treatment of T-cell lymphoblastic leukemia and lymphoma, which generally include providing a patient with an effective amount of one or more NOTCH-1 inhibitors. | 04-15-2010 |
20110118192 | METHODS AND COMPOSITIONS FOR TREATING T-CELL LEUKEMIA - The present invention relates to compositions and methods that may be used to diagnose and treat cancer, particularly T-cell leukemia. According to one preferred embodiment of the present invention, methods are provided for determining whether reducing or blocking NOTCH-1 activation will be effective to treat, prevent, or ameliorate the effects of a cancer in a patient, including T-cell leukemia, myeloleukemia, neuroblastoma, breast cancer, and ovarian cancer. The methods generally include determining if the patient harbors one or more mutations in a PTEN coding region. In particular, the methods may be used to determine whether reducing or blocking NOTCH-1 activation, with one or more γ-secretase inhibitors, will be effective to treat, prevent, or ameliorate the effects of a cancer in a patient. | 05-19-2011 |
20130064810 | Methods and Compositions for the Detection and Treatment of Cancer involving miRNAs and miRNA Inhibitors and Targets - The present invention relates to microRNAs (miRNAs) which are associated with cancer, particularly including hematologic malignancies, and particularly T-cell acute lymphoblastic leukemia (T-ALL), and to the assessment and modulation thereof in the treatment and management of cancer. The present invention is directed to methods and compositions for diagnosing and treating cancer, particularly T-ALL, by modulating miRNAs, and the use of miRNAs and antagonists thereof, particularly antagomirs, for predicting and assessing response to treatment, in assays for isolating and selecting antagists, and as compositions for the treatment and management of cancer. Methods and compositions are provided for treatment or alleviation of cancer, particularly T-ALL, with antagonists/antagomirs of miRNAs, particularly one or more of miR-19b, miR-20a, miR26, miR92, miR148 and miR223. | 03-14-2013 |
Patent application number | Description | Published |
20090126552 | Method of Producing Parts for Woodwind and Brass Musical Instruments Using Briarwood - The invention relates to a method of producing parts for woodwind and brass musical instruments using briarwood, either from the root or branch thereof, said wood being kept moist from the moment it is cut until it is boiled in water for 16 hours, dried in anaerobic conditions and cured under cover for at least six months and for up to two or more years. The following parts can be thus produced: mouthpiece, tongue, clarinet barrel, flute head or bell. The aforementioned parts, which are not affected by humidity, better produce and carry the sound. In addition, a wide range of sounds is possible, such as jazz, classical, soloist, orchestra and band. | 05-21-2009 |
20140260891 | CLAMP FOR A SAXOPHONE OR CLARINET MOUTHPIECE - A clamp includes a flexible, interior conical component in contact with a barrel and a rigid, exterior conical component in contact with the interior component. The interior component has a longitudinal cut over its entire length and has, at the part that contacts the barrel, two central recesses. The exterior component acts on the interior component, and has the same conicity as the interior component. The exterior component prevents unwanted opening of the interior component by exerting a pressure on the interior component. Both components have a central recess, which form, as a whole, a mouthpiece resonating box that provides greater sound volume and different timbres, depending on the size of the recess and on the material from which it is produced. The flexibility of the interior component prevents breaking of the barrel even though three interior rings thereof are placed in different planes. | 09-18-2014 |
Patent application number | Description | Published |
20090278280 | Method for manufacturing biodegradable cinerary urns - A method that contemplates the use of materials selected from amongst aggregates, aromatic plants, vegetal organic matter and combinations thereof, that are then mixed with vegetal agglutinant agents and the resulting mixture poured inside molds that are subjected to a pressure treatment and then, once they have had time to dry, to a heat application which purpose is to consolidate the urn ( | 11-12-2009 |
20110089605 | Method for manufacturing biodegradable cinerary urns - A method that comprises the use of materials selected from amongst aggregates, aromatic plants, vegetal organic matter, plant earth, beach sand, marine salt, and combinations thereof, that are then mixed with vegetal agglutinant agents and the resulting mixture poured inside molds that are subjected to a pressure treatment and then, once they have had time to dry, to a heat application which purpose is to consolidate the urn ( | 04-21-2011 |