Patent application number | Description | Published |
20080229438 | Process of making transgenic mammals that produce exogenous proteins in milk and transgenic mammals produced thereby - The invention relates to a method of producing a protein of interest, comprising making a non-human transgenic mammal that produces said protein in its milk, obtaining said milk from the non-human transgenic mammal and purifying said protein of interest from the milk. Transgenic bovine animals were generated, which are able to produce human growth hormone in mammary glands. The method involves cloning of a genetic construct encoding hGH gene and beta casein promoter conveniently in an expression vector. It also includes transfection procedures into fetal bovine somatic cells, generally fibroblasts, and the nuclear transfer into enucleated bovine oocytes, generating thus transgenic embryos. The method also includes other procedures to generate transgenic embryos for the further expansion of the transgenic herd, such as the subcloning of transgenic female bovines, the superovulation of transgenic cows and their insemination with semen from a non-transgenic or a transgenic male bovine, and the superovulation of non-transgenic cows and their insemination with semen from a transgenic male bovine. Afterwards, transgenic embryos give rise to transgenic cattle that produce human growth hormone in huge amounts in their milk, from which the hormone is completely purified and analysed to fulfill all the requirements for the manufacture of a pure biopharmaceutical product. | 09-18-2008 |
20110072526 | PROCESS FOR PRODUCING EXOGENOUS PROTEIN IN THE MILK OF TRANSGENIC MAMMALS AND A PROCESS FOR PURIFYING PROTEINS THEREFROM - The invention relates to a method of producing a protein of interest, comprising making a non-human transgenic mammal that produces said protein in its milk, obtaining said milk from the non-human transgenic mammal and purifying said protein of interest from the milk. Transgenic bovine animals were generated, which are able to produce human growth hormone in mammary glands. The method involves cloning of a genetic construct comprising the hGH gene and beta casein promoter sequences conveniently in an expression vector. It also includes transfection procedures into fetal bovine somatic cells, generally fibroblasts, and the nuclear transfer into enucleated bovine oocytes, generating thus transgenic embryos. The method also includes other procedures to generate transgenic embryos for further expansion of the transgenic herd, such as the subcloning of transgenic female bovines, the superovulation of transgenic cows and their insemination with semen from a non-transgenic or a transgenic male bovine, and the superovulation of non-transgenic cows and their insemination with semen from a transgenic male bovine. Afterwards, transgenic embryos give rise to transgenic cattle that produce human growth hormone in huge amounts in their milk, from which the hormone is completely purified and analysed to fulfill all the requirements for the manufacture of a pure biopharmaceutical product. | 03-24-2011 |
Patent application number | Description | Published |
20100217041 | ENHANCED PROCESS FOR THE SYNTHESIS OF UREA - An enhanced process is described for the synthesis of urea from ammonia and carbon dioxide, at a high pressure and temperature, with the formation of ammonium carbamate as intermediate, which includes a high pressure synthesis section, comprising at least one separation step by decomposition-stripping with ammonia of the non-converted ammonium carbamate, carried out in a vertical apparatus, commonly called stripper, characterized in that said step also comprises a feeding, in the lower part of said stripper, of a stream of CO | 08-26-2010 |
20120097378 | TUBE BUNDLE EQUIPMENT WITH LIQUID FLOW REGULATOR ELEMENTS - Tube-bundle equipment of the falling liquid film type, comprising a vertical cylindrical body closed at the ends and divided into at least an upper section, an intermediate section and a lower section by means of two perforated tube sheets arranged transversally to support the tubes forming the bundle, wherein each of said tubes is surmounted, on the upper end, by a ferrule, for the inlet and distribution of the liquid in the form of a film, which comprises in the upper part, one or more openings for the outlet of vapours, at an intermediate height one or more openings, preferably tangential, for the inlet of the liquid and below, a circular base for resting on said tube from which an internal cylindrical section, inserted in the tube for a length varying from 10 to 200 mm, protrudes downwards together with an outer metallic strip for a length of at least 2 mm, so that, in the circular area defined between said outer metallic strip and said protruding cylindrical section, there is a gasket, inserted between said circular base of the ferrule and said upper edge of the tube. | 04-26-2012 |
20130123536 | TUBE-BUNDLE EQUIPMENT FOR PROCESSING CORROSIVE FLUIDS - Tube-bundle equipment for heat exchange operations at high pressures and temperatures, under conditions of high aggressiveness of the process fluids, comprising a titanium lining ( | 05-16-2013 |
20150025273 | PROCESS FOR THE SYNTHESIS OF UREA COMPRISING A PASSIVATION STREAM AT THE STRIPPER BOTTOM - A process for the direct synthesis of urea from ammonia and carbon dioxide with increased corrosion resistance, comprising, in the high-pressure synthesis section, a reaction step in a vertical reactor fed with at least one stream of fresh carbon dioxide containing a passivating agent and a decomposition-stripping step of the non-converted reagents, wherein the gas-liquid mixture collected at the head of the reactor is separated into a gaseous stream and a liquid stream fed to the tail and head of the stripper, respectively. | 01-22-2015 |
Patent application number | Description | Published |
20100193346 | PROCESS FOR THE PURIFICATION OF AN AQUEOUS STREAM COMING FROM THE FISCHER-TROPSCH REACTION - The present invention relates to a process for the purification of an aqueous stream coming from the Fischer-Tropsch reaction which comprises:—feeding of the aqueous stream containing the organic by-products of the reaction to a system consisting of a distillation column equipped with a partial condenser and a total condenser;—partial condensation of the vaporized stream leaving the head of the column and collection of a first distillate enriched in the heavier by-products;—total condensation of the vaporized stream leaving the partial condenser and collection of a liquid stream which is partly sent back to the distillation column as reflux whereas the remaining part is collected as distillate;—extraction of the purified aqueous stream from the bottom of the distillation column. | 08-05-2010 |
20110100819 | PROCESS FOR THE TREATMENT OF THE AQUEOUS STREAM COMING FROM THE FISCHER-TROPSCH REACTION - The present invention relates to a process for the treatment of the aqueous stream coming from the Fischer-Tropsch reaction which comprises: —feeding of the aqueous stream containing organic by-products of the reaction to a distillation or stripping column; —collection from the column of a distillate enriched in alcohols having from 1 to 8 carbon atoms and other possible volatile compounds; feeding of the aqueous stream containing the acids leaving the bottom of the distillation column to an electrodialysis cell and the production of two outgoing streams: —an aqueous stream (i) enriched in organic acids having from 1 to 8 carbon atoms; —a purified aqueous stream (ii) with a low acid content. | 05-05-2011 |
20110127155 | PROCESS FOR THE TREATMENT OF THE AQUEOUS STREAM COMING FROM THE FISCHER-TROPSCH REACTION - The present invention relates to a process for the treatment of the aqueous stream coming from the Fischer-Tropsch reaction, comprising: —feeding the aqueous stream ( | 06-02-2011 |
20120055868 | PROCESS FOR THE PURIFICATION OF AN AQUEOUS STREAM COMING FROM THE FISCHER-TROPSCH REACTION - Process for the purification of an aqueous stream coming from the Fischer-Tropsch reaction which comprises: —feeding said aqueous stream containing the organic by-products of the reaction to a distillation column, obtaining two output streams: —an aqueous stream (i) exiting from the column head, enriched with alcohols having from 1 to 20 carbon atoms, preferably from 1 to 9 carbon atoms, and other optional volatile compounds; an aqueous stream (ii) exiting from the column bottom, enriched with organic acids having from 1 to 10 carbon atoms, preferably from 2 to 6 carbon atoms; —subjecting said aqueous stream (ii) to an anaerobic biological treatment obtaining a purified aqueous stream (iii); wherein said anaerobic biological treatment is carried out with a hydraulic retention time lower than 15 hours, preferably ranging from 4 hours to 10 hours, more preferably ranging from 5 hours to 8 hours. | 03-08-2012 |
20130008774 | PROCESS FOR THE PURIFICATION OF AN AQUEOUS STREAM COMING FROM THE FISCHER-TROPSCH REACTION - Process for the purification of an aqueous stream coming from the Fischer-Tropsch reaction which comprises a distillation and/or stripping treatment, a treatment with at least one inorganic base and a treatment with at least one organic base. Said process allows at least a part of the aqueous stream coming from the Fischer-Tropsch reaction to be used as process water in the synthesis gas production plant, subsequently sent to the Fischer-Tropsch plant for the production of hydrocarbons. | 01-10-2013 |
20130256117 | PROCESS FOR THE PURIFICATION OF AN AQUEOUS STREAM COMING FROM THE FISCHER TROPSCH REACTION - Process for the purification of an aqueous stream coming from the Fischer-Tropsch reaction, which comprises feeding a part of said aqueous stream to a saturator, feeding a part of said aqueous stream to a distillation and/or stripping column, feeding the aqueous stream leaving the head of said distillation and/or stripping column to said saturator. Said process allows at least a part of the aqueous stream coming from the Fischer-Tropsch reaction to be used as process water in the synthesis gas production plant, subsequently sent to the Fischer Tropsch plant for the production of hydrocarbons. | 10-03-2013 |
20130299334 | PROCESS FOR THE PURIFICATION OF AN AQUEOUS STREAM COMING FROM THE FISCHER-TROPSCH REACTION - Process for the purification of an aqueous stream coming from the Fischer-Tropsch reaction comprising a treatment with at least one inorganic base, an evaporation treatment, a distillation and/or stripping treatment and a treatment with at least one organic base. Said process allows at least a part of the aqueous stream coming from the Fischer-Tropsch reaction to be used as process water in the production plant of synthesis gas subsequently sent to a Fischer-Tropsch plant for the production of hydrocarbons. | 11-14-2013 |
Patent application number | Description | Published |
20090263359 | Particulate Delivery Vehicles for Embryoid Bodies - The present invention provides a vehicle for delivering various chemicals, compositions and proteins to stem cells and embryoid bodies. The vehicle may be biocompatible and biodegradable polymer microparticles. Typically the particles will contain at least a growth factor for delivery to the embryoid bodies, and generally the growth factor induces differentiation of the cells in the embryoid body along a specific lineage. The present invention also provides methods for directing differentiation of the cells in the embryoid body. | 10-22-2009 |
20100215708 | COATING OF DEVICES WITH EFFECTOR COMPOUNDS - This invention is directed to substrates, materials and devices coated with a gel, foam, film, particle or composition comprising a polymei solvent and effector compounds attached thereto, processes of producing the same, and methods of use thereof, of in, inter-alia, biological applications, including preventing infection and the treatment of various diseases. | 08-26-2010 |
20130216600 | ANTIMICROBIAL NANOPARTICLE CONJUGATES - The present invention provides antimicrobial nanoparticle conjugates and an efficient method of preparing same. In particular, the invention relates to the preparation of antifungal nanoparticle conjugates comprising amphotericin B covalently immobilized to nanoparticles. The conjugates, and suspensions thereof, can be used to form antifungal coatings with particular application to medical devices and materials. | 08-22-2013 |
20130231412 | URETHANE-CROSSLINKED BIODEGRADABLE ELASTOMERS - Among other things, the present disclosure provides compositions and methods for an elastomeric cross-linked polyester material. Such an elastomeric cross-linked polyester material, in some embodiments, comprises a plurality of polymeric units of the general formula (-A-B—) | 09-05-2013 |
20140147420 | COMPOSITION AND METHOD TO IMPROVE THE THERAPEUTIC EFFECT OF STEM CELLS - The invention relates to a composition and method used for injuries treatment with a surprisingly therapeutic effect. This composition comprises a population of cells derived from human umbilical cord blood which expresses one of the following markers: CD34, CD45, and CD31; a population of CD34 | 05-29-2014 |
20140186312 | Method Comprising Contacting Tissue With a Cross-Linkable Polyester Prepolymer - The present inventions in various aspects provide elastic biodegradable polymers. In various embodiments, the polymers are formed by the reaction of a multifunctional alcohol or ether and a difunctional or higher order acid to form a pre-polymer, which is cross-linked to form the elastic biodegradable polymer. In preferred embodiments, the cross-linking is performed by functionalization of one or more OR groups on the pre-polymer backbone with vinyl, followed by photopolymerization to form the elastic biodegradable polymer composition or material. Preferably, acrylate is used to add one or more vinyls to the backbone of the pre-polymer to form an acrylated pre-polymer. In various embodiments, acrylated pre-polymers are co-polymerized with one or more acrylated co-polymers. | 07-03-2014 |
20140341811 | Nanoparticles and Uses Thereof - A nanoparticle conjugate for intracellular delivery of a therapeutic agent, wherein the conjugate comprises a nanoparticle, a cationic agent and the therapeutic agent. Pharmaceutical compositions, medicaments and therapeutic uses thereof are also provided. | 11-20-2014 |
20150079174 | ANTIMICROBIAL COMPLEXES - The invention relates to an antimicrobial surfactant complexed with a nanomaterial. The surfactant can be a quaternary ammonium cationic surfactant which is coated on the surface of a nanomaterial such as a silica nanoparticle or a carbon nanotube. | 03-19-2015 |
20150139962 | COMPOSITION AND METHOD OF STEM CELLS FOR PRESERVATION OF CARDIAC TISSUE - The present disclosure describes a method and composition for enhancing the survival of hematopoietic stem cells, preferably CD34+ derived from human umbilical cord or peripheral blood, in hypoxic and serum-deprived conditions by cultivating the cells in medium containing lysophosphatidic acid, preferably further comprising a gel, namely a biomimetic gel. | 05-21-2015 |
20150224225 | ANTIMICROBIAL COATING COMPOSITIONS - The invention relates to an antimicrobial coating composition for coating articles comprising: an antimicrobial peptide and a nanoparticle bound to said antimicrobial peptide, wherein the composition is suitable to be bonded to the surface of the article. The composition can comprise a coating composition of medical devices and laboratory surfaces. | 08-13-2015 |
20150329822 | DIFFERENTIATED CELL POPULATION OF ENDOTHELIAL CELLS DERIVED FROM HUMAN PLURIPOTENT STEM CELLS, COMPOSITION, SYSTEM, KIT AND USES THEREOF - The present disclosure relates to a differentiated cell population of endothelial cells derived from human pluripotent stem cells. The present invention also relates to a composition, a system and a kit comprising those cells and uses thereof. The present disclosure also described the combination of arterial ECs derived from human pluripotent stem cells with a microfluidic system to create a vascular kit for high-throughput drug screening and/or toxicology analysis. This technology may find particular use for the identification of drugs that may have a fetal cytotoxic effect. | 11-19-2015 |
Patent application number | Description | Published |
20110023820 | PNEUMATIC HYBRID INTERNAL COMBUSTION ENGINE ON THE BASIS OF FIXED CAMSHAFTS - The present disclosure relates to an pneumatic hybrid internal combustion engine with at least one combustion chamber composed of a cylinder in which a piston is arranged mechanically interconnected to a crank shaft via a piston rod. An inlet valve and an exhaust valve are both mechanically interconnected via a valve gear to the crank shaft. The engine further includes at least one charge valve which is actuated by a charge valve actuator in a fully variable manner such that the engine can be operated in a four stroke hybrid mode. | 02-03-2011 |
20120067030 | METHOD FOR PURIFYING THE EXHAUST GASES OF AN INTERNAL COMBUSTION ENGINE HAVING A CATALYTIC CONVERTER - The present invention relates to a method for purifying the exhaust gases of an internal combustion engine having a catalytic converter which comprises oxygen storage components. The invention is concerned particularly with the restoration of the optimum filling degree of the oxygen storage components for regulated stoichiometric operation after the engine has been operated under lean conditions for a relatively short or relatively long period of time. | 03-22-2012 |
20120186249 | TURBOCHARGED RECIPROCATING PISTON ENGINE HAVING A CONNECTED PRESSURE TANK FOR BRIDGING TURBO LAG, AND METHOD FOR OPERATING SAID ENGINE - The present invention relates to a turbo-charged reciprocating piston engine having a combustion chamber, and to a method for operating said engine. The combustion chamber has at least one inlet valve ( | 07-26-2012 |
20150247446 | Method for Operating a Spark Ignition Internal Combustion Engine with an Exhaust Gas Turbocharger - A method is provided for operating a spark ignition internal combustion engine with an ignition angle adjustment by a control unit and with an exhaust gas turbocharger with a turbine and a compressor and, wherein a throttle valve is provided in an intake air manifold between the compressor and the internal combustion engine. A compressed air device is provided for introducing compressed air into the intake air manifold, including at least one pressure tank and an air injection valve that can be opened by the control unit and is connected to provide gas to the pressure tank for introducing compressed air into the intake air manifold between the throttle valve and the internal combustion engine. A first gas pressure is measured in the intake air manifold between the compressor and the throttle butterfly and a second gas pressure is measured between the throttle valve and the internal combustion engine. The throttle valve can be controlled or regulated by the control unit. | 09-03-2015 |
Patent application number | Description | Published |
20120197263 | Instrument Set for Screwing an Implant Into an Intervertebral Disc Space - An instrument set for screwing an implant into an intervertebral disc space comprises a guide sleeve and a screwing-in instrument. The latter has a shank having a distal end at which the implant can be fixed in a rotationally rigid manner. At the proximal end a rotary handle is fastened in a rotationally rigid manner. The screwing-in instrument further has a residual-advance indicator, which is configured to quantitatively indicate to the surgeon, during the screwing-in procedure, how far the implant is distant in the axial direction from an axial specified position that is fixed relative to the location at which the guide sleeve is supported on the vertebrae. | 08-02-2012 |
20140088650 | Polyaxial Connector for Spinal Fixation Systems - A polyaxial connector for spinal fixation systems has a lateral connector element having a first receptacle for a polyaxial connection to a spherical head of a pedicle screw and a second receptacle for a polyaxial connection to a spherical head of tulip that is configured to receive a connection rod clamped in the tulip by a locking element. A clamping piece is mounted in longitudinally-movable manner in the connector element between the receptacles. If the locking element is tightened, a pressure ram received in the tulip exerts a clamping force on the pedicle screw head, thereby fixing the connector element to the pedicle screw. | 03-27-2014 |
20140156007 | Expandable Cage for the Intercorporal Fusion of Lumbar Vertebrae - An expandable cage for intercorporal fusion of lumbar vertebrae comprises a main body with two expandable parallel arms. Each arm has a supporting surface pointing outside and configured to contact an adjacent vertebral body, a groove pointing inside and extending along a transverse direction, and a channel pointing inside and extending along a longitudinal direction. An expansion element is instrument actuated and presses the arms apart expanding the cage. The expansion element is between the arms and comprises a cylindrical base body, two opposing radially aligned ribs on the base body, and a rectangular plate. Both the base body and ribs have curved, pair-wise opposed bearing surfaces. Depending on the cage's expansion state, either the base body bearing surfaces or the rib bearing surfaces contact channels provided in the arms, while the plate engages in the grooves of the arms. | 06-05-2014 |