Patent application number | Description | Published |
20080200656 | Use Of Sucrose To Suppress Mannitol-Induced Protein Aggregation - The present invention provides a method for suppressing mannitol-induced protein aggregation by providing sucrose to a liquid formulation containing a protein. The present invention also provides methods for storing and preparing a liquid formulation containing a protein and a combination of mannitol and sucrose such that the presence of sucrose suppresses mannitol-induced protein aggregation. | 08-21-2008 |
20090311241 | Human antibodies that bind human IL-12 and methods for producing - Human antibodies, preferably recombinant human antibodies, that specifically bind to human interleukin-12 (hIL-12) are disclosed. Preferred antibodies have high affinity for hIL-12 and neutralize hIL-12 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, of the invention are useful for detecting hIL-12 and for inhibiting hIL-12 activity, e.g., in a human subject suffering from a disorder in which hIL-12 activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies of the invention, and methods of synthesizing the recombinant human antibodies, are also encompassed by the invention. | 12-17-2009 |
20100166752 | Anti A Beta Antibody Formulation - The present invention provides formulations for maintaining the stability of Aβ binding polypeptides, for example, Aβ antibodies. Exemplary formulations include a tonicity agent such as mannitol and a buffering agent or amino acid such as histidine. Other exemplary formulations include an antioxidant in a sufficient amount as to inhibit by-product formation, for example, the formation of high molecular weight polypeptide aggregates, low molecular weight polypeptide degradation fragments, and mixtures thereof. The formulations of the invention optionally comprise a tonicity agent, such as mannitol, and a buffering agent or amino acid such as histidine. The formulations are suitable for several different routes of administration. | 07-01-2010 |
20100172862 | STABLE ANTIBODY COMPOSITIONS AND METHODS OF STABILIZING SAME - The invention provides compositions and methods for inhibiting fractionation of immunoglobulins comprising a lambda light chain based on the observation that iron, in the presence of histidine, results in increased fragmentation of a recombinant fully human IgG molecule containing a lambda light chain due to cleavage in the hinge region. The invention further provides an aqueous pharmaceutical formulation comprising an antibody, or antigen-binding portion thereof, that binds the p40 subunit of IL-12/IL-23 and a buffer system comprising histidine, wherein the formulation has enhanced stability, including enhanced resistance to fragmentation. | 07-08-2010 |
20110123544 | HUMAN ANTIBODIES THAT BIND HUMAN IL-12 AND METHODS FOR PRODUCING - Human antibodies, preferably recombinant human antibodies, that specifically bind to human interleukin-12 (hIL-12) are disclosed. Preferred antibodies have high affinity for hIL-12 and neutralize hIL-12 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, of the invention are useful for detecting hIL-12 and for inhibiting hIL-12 activity, e.g., in a human subject suffering from a disorder in which hIL-12 activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies of the invention, and methods of synthesizing the recombinant human antibodies, are also encompassed by the invention. | 05-26-2011 |
20120114646 | LYOPHILIZED FORMULATIONS FOR SMALL MODULAR IMMUNOPHARMACEUTICALS - The present invention provides, among other things, stable formulations for small modular immunopharmaceutical (SMIP™) proteins. In some embodiments, the present invention provides a formulation containing a lyophilized mixture of a small modular immunopharmaceutical protein, wherein less than 7% of the lyophilized small modular immunopharmaceutical protein exists in aggregated form. Formulations according to the invention may contain buffering agents, stabilizers, bulking agents, surfactants and/or other excipients. The present invention also provides formulations for lyophilization, reconstitution and methods of use thereof. | 05-10-2012 |
20120201831 | HUMAN ANTIBODIES THAT BIND HUMAN IL-12 AND METHODS FOR PRODUCING - Human antibodies, preferably recombinant human antibodies, that specifically bind to human interleukin-12 (hIL-12) are disclosed. Preferred antibodies have high affinity for hIL-12 and neutralize hIL-12 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, of the invention are useful for detecting hIL-12 and for inhibiting hIL-12 activity, e.g., in a human subject suffering from a disorder in which hIL-12 activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies of the invention, and methods of synthesizing the recombinant human antibodies, are also encompassed by the invention. | 08-09-2012 |
20150071944 | STABLE ANTIBODY COMPOSITIONS AND METHODS OF STABILIZING SAME - The invention provides compositions and methods for inhibiting fractionation of immunoglobulins comprising a lambda light chain based on the observation that iron, in the presence of histidine, results in increased fragmentation of a recombinant fully human IgG molecule containing a lambda light chain due to cleavage in the hinge region. The invention further provides an aqueous pharmaceutical formulation comprising an antibody, or antigen-binding portion thereof, that binds the p40 subunit of IL-12/IL-23 and a buffer system comprising histidine, wherein the formulation has enhanced stability, including enhanced resistance to fragmentation. | 03-12-2015 |
Patent application number | Description | Published |
20130066975 | Group Opt-In Links - Techniques for sharing of items from online storage (e.g., cloud storage) are described herein. In some embodiments, sharing links can be configured as group opt-in links designed to provide recipients with an option to join a group having permissions on a corresponding shared item. A sharing link to an item may be generated and provided to a user for distribution to recipients in various ways. When selected by recipients, the sharing link causes an option to be exposed to the recipients to opt-in to a group having permissions on a corresponding item. Group membership is determined by recipients that exercise the option and recipients that opt-in are granted permissions on the item established for the group. Subsequently, an owner of the item/group may view a list of recipients who have opted-in as members and manage corresponding permissions on an individual basis. | 03-14-2013 |
20130067303 | Distinct Links for Publish Targets - Techniques for sharing of items from online storage (e.g., cloud storage) are described herein. In one approach, distinct sharing links to an item can be generated for multiple different publish targets through a single publishing user interface exposed to a user. Through the publishing user interface, a user may submit a request having a selection of different social networks and/or other sites/targets to receive a sharing link for an item. In response to the request, a distinct sharing link is generated for each selected recipient and the generated sharing links are published to appropriate targets. Thus, a user is able to easily send links for a shared item to multiple targets through a single request and can separately manage permissions associated with each distinct sharing link. | 03-14-2013 |
20130067594 | Shared Item Account Selection - Techniques for sharing of items from online storage (e.g., cloud storage) are described herein. In at least some embodiments, sharing links can be configured as one-time sharing links that provide recipients with limited, one-time access to a shared item for the purpose of selecting or registering an account to use for subsequent access to the item. Recipients are able to select accounts they find most convenient for accessing a shared item without the owner/sharer of the item necessarily having contact information for those accounts or sending a link to the accounts. Selection of a one-time link initiates an authentication sequence that selectively provides an option to select a particular account. Once the one-time sharing link is redeemed, the one-time sharing link is invalidated for subsequent access to the item. | 03-14-2013 |
20130117376 | DOCUMENT COLLABORATION - One or more techniques and/or systems provide for an entity to receive collaboration context data regarding activities that have taken place with respect to a document when the entity views a reference to the document comprised within a communication directed to the entity. For example, a hyperlink related to a document may be emailed to an entity when the document is shared with the entity. Subsequently, when the entity views the email comprising the hyperlink, the entity may be provided with contextual information regarding the document (e.g., entities that have viewed the document, edits other entities have made to the document, etc.). In one embodiment, such information may be presented to the entity in the same application (e.g., email client and/or email service) as the email. In this way, the entity may be provided with information that may help the entity assess whether to access a shared document, for example. | 05-09-2013 |
Patent application number | Description | Published |
20120260188 | POTENTIAL COMMUNICATION RECIPIENT PREDICTION - One or more techniques and/or systems are provided for identifying potential recipients for a communication (e.g., email, instant message, content sharing platform, etc.) a user is presently preparing based at least in part upon a user's communication history. That is, information about the user's interactions with past recipients of his/her communications are compared with information known about the present communication and potential recipients of the present communication are identified based upon this comparison. Moreover, in one embodiment, based upon the past interactions of the user with others, one or more communication groups can be identified and presented to the user. In this way, a user may select a communication group and recipients included in the communication group can be added as recipients for the communication the user is presently preparing without the user having to manually create such groups, for example. | 10-11-2012 |
20140282921 | RESOURCE-BASED ACTION ATTRIBUTION - A system of resource-based action attribution provides a mechanism for tracking actions performed on a resource shared among multiple users of a resource sharing system, whether the users are authenticated within the resource sharing system or not. The tracking mechanism may allow users to track identifying information of other users who perform actions (e.g., editing actions) on the shared resource. A user can access a resource by providing a resource identifier and/or an access credential associated with the resource. The user's actions on the resource can be associated with an invitee identifier (e.g., an email address) that is associated in memory with the resource identifier and/or the access credential. | 09-18-2014 |
Patent application number | Description | Published |
20110142197 | PATIENT POSITIONING SYSTEM FOR PANORAMIC DENTAL RADIATION IMAGING SYSTEM - A patient positioning system for a panoramic dental radiation imaging system, including an upright support, and a patient positioning arm with chin rest mounted thereto. Wands are each rotatably connected to the patient positioning arm and connected together so as to move at identical angles of rotation, but in the opposite direction. Lasers, including a mid-sagittal, a Frankfort Plane, two cuspid, and one toe laser, each providing a line of visible laser light directed at a respective area of a patient's face, or at the floor, assist a technician in properly positioning the patient. A mirror is mounted to the upright support by a mechanism that permits the mirror to be pivoted outward from the support, in either of two directions, so as to enable the technician to see the lasers on the patient's face from the technician's position on either side of the positioning arm. | 06-16-2011 |
20110142198 | REMOVABLE RADIATION SENSOR FOR DENTAL IMAGING SYSTEMS - A removable radiation sensor for connecting to a panoramic dental radiation imaging system. The sensor includes a radiation sensor unit mounted in a housing. Connector bearings are positioned within the housing so as to engage with a pair of connector pins provided as part of the upright support of the imaging system. A lock pin within the housing is selectively slidable between Locked and Unlocked, and biased toward Locked. The lock includes a locking pin with a groove, and when the groove is aligned with the respective connector pin, the lock is unlocked, and that connector pin is slidable axially within the bearings. When the groove is not aligned with the connector pin, the lock is locked, the locking pin engaging with a groove formed for that purpose in the connector pin. The sensor has a field-replaceable electrical connector, to reduce maintenance cost. | 06-16-2011 |
20110142199 | MOTION SYSTEM FOR PANORAMIC DENTAL RADIATION IMAGING SYSTEM - A motion system for use in a panoramic dental radiation imaging system, including apparatus for rotating an overhead arm with respect to a support column, apparatus for rotating a C-arm with respect to the overhead arm, and apparatus for moving the C-arm axially with respect to the overhead arm. The overhead arm is rotatably mounted to the support column at a rotation point. The apparatus for rotating the overhead arm is a linear actuator, one end of which is connected to the support column at a first point spaced apart from the rotation point, while the other end is connected to the overhead arm at a second point spaced apart from the rotation point and from the first point. The C-arm rotating apparatus includes a C-arm rotation motor driving a wheel, which is engaged with the C-arm in such a way that the rotation of the wheel causes rotation of the C-arm. | 06-16-2011 |
20120039445 | Modular Fixed Beam-Limiting Device For Intraoral X-Ray System - A modular beam-limiting device for use with an x-ray machine includes a base portion and an attachment portion. The base portion includes at least one magnet. The attachment portion includes at least one magnet. The base portion is adapted to be received on an x-ray tubehead housing. The attachment portion is selectively removably couplable to said base portion. The modular beam-limiting device may further include a magnetic field modulator, which is operable to shape a magnetic field; an insert for configuring a size, a shape, or an orientation of an aperture of the beam-limiting device; or an adapter for increasing an axial length of the beam-limiting device. | 02-16-2012 |
Patent application number | Description | Published |
20150336667 | UNMANNED AERIAL VEHICLE PLATFORM - A device receives a request for a flight path of UAV from a first location to a second location in a region, and determines, based on credentials associated with the UAV, whether the UAV is authenticated for utilizing the device and a network. The device determines, when the UAV is authenticated, capability information for the UAV based on the request and component information associated with the UAV. The device calculates the flight path from the first location to the second location based on the capability information and one or more of weather information, air traffic information, obstacle information, or regulatory information associated with the region. The device generates flight path instructions for the flight path based on one or more of the weather information, the air traffic information, the obstacle information, or the regulatory information associated with the region, and provides the flight path instructions to the UAV. | 11-26-2015 |
20150336668 | UNMANNED AERIAL VEHICLE FLIGHT PATH DETERMINATION, OPTIMIZATION, AND MANAGEMENT - A device receives a request for a flight path from a first location to a second location in a region. The request includes component information associated with components of UAVs in a group. The device calculates a most efficient flight path from the first location to the second location based weather information, air traffic information, obstacle information, or regulatory information associated with the region, and determines capability information for the UAVs in the group based on the component information. The device selects, from the UAVs in the group, a particular UAV that is capable of traversing the most efficient flight path based on the capability information, and generates flight path instructions for the most efficient flight path. The device provides the flight path instructions to the particular UAV to permit the particular UAV to travel from the first location to the second location via the most efficient flight path. | 11-26-2015 |
20150336669 | UNMANNED AERIAL VEHICLE NETWORK-BASED RECHARGING - A device receives a request for a flight path for a UAV to travel from a first location to a second location, and determines capability information for the UAV based on component information of the UAV. The device calculates the flight path based on the capability information, identifies multiple recharging stations located on or near the flight path, and selects a recharging station from the multiple recharging stations based on one or more factors. The device generates flight path instructions, for the flight path, that instruct the UAV to stop and recharge at the recharging station. The device provides the flight path instructions to the UAV to permit the UAV to travel from the first location to a location of the recharging station, stop and recharge at the recharging station, and travel from the location of the recharging station to the second location via the flight path. | 11-26-2015 |
20150339933 | CONFIGURABILITY OPTIONS FOR INFORMATION, AIRSPACE, AND PROPERTY UTILIZED BY AN UNMANNED AERIAL VEHICLE PLATFORM - A device receives aviation information associated with aviation in a geographical region, and receives configurability options associated with the aviation information. The device analyzes the aviation information based on the configurability options to generate analyzed information, and receives a request for a flight path for a UAV to travel from a first location to a second location in the geographical region. The device calculates the flight path from the first location to the second location based on the analyzed information and capability information associated with the UAV, and generates flight path instructions for the flight path. The device provides the flight path instructions to the UAV to permit the UAV to travel from the first location to the second location via the flight path. | 11-26-2015 |
Patent application number | Description | Published |
20080279887 | METHOD OF ENHANCING A TARGETED IMMUNE RESPONSE AGAINST TUMORS - The present invention is a composition of recombinant virus which has incorporated into its genome or portion thereof a gene encoding an antigen to a disease causing agent and a recombinant virus which has incorporated into its genome or portion thereof a gene encoding an immunostimulatory molecule(s) for the purpose of stimulating an immune response against the disease causing agent. Methods of treatment of diseases such as cancer and diseases caused by pathogenic microorganisms is provide using the composition. | 11-13-2008 |
20090155232 | Neonatal human hepatocytes immortalized using tert and methods of their use - The present invention relates to the discovery of immortalized neonatal human hepatocytes that exhibit phenotypic features of human hepatic progenitor cells. The invention is also directed to a method of obtaining telomerase-immortalized neonatal human hepatocytes that exhibit phenotypic features of human hepatic progenitor cells. Furthermore, the instant invention describes methods of using the immortalized neonatal human hepatocytes in cellular therapies, toxicological studies, pharmacokinetic studies, metabolic studies, therapeutic gene delivery and for the production of fully differentiated hepatocytes. | 06-18-2009 |
20130189268 | COLON AND PANCREAS CANCER SPECIFIC ANTIGENS AND ANTIBODIES - This invention relates to NPC-1 antigen on the MUC5AC protein and 16C3 antigen on CEACAM5 and CEACAM6 proteins, and 31.1 epitope on the A33 protein are differentially expressed in cancers including, lung cancer, ovarian cancer, pancreas cancer, breast cancer, and colon cancer, and diagnostic and therapeutic usages. Further, NPC-1, 16C3, and/or 31.1 epitope specific antibodies and diagnostic and therapeutic methods of use. | 07-25-2013 |
Patent application number | Description | Published |
20090162931 | RECOMBINANT MONOCLONAL ANTIBODIES AND CORRESPONDING ANTIGENS FOR COLON AND PANCREATIC CANCERS - The present invention provides for recombinant monoclonal antibodies that bind to human colorectal and pancreatic carcinoma-associated antigens, along with nucleic acid sequences encoding the antibody chains, and the amino acid sequences corresponding to the nucleic acids, and uses for these antibodies, nucleic acids and amino acids. | 06-25-2009 |
20110076761 | RECOMBINANT MONOCLONAL ANTIBODIES AND CORRESPONDING ANTIGENS FOR COLON AND PANCREATIC CANCERS - The present invention provides for recombinant monoclonal antibodies that bind to human colorectal and pancreatic carcinoma-associated antigens, along with nucleic acid sequences encoding the antibody chains, and the amino acid sequences corresponding to the nucleic acids, and uses for these antibodies, nucleic acids and amino acids. | 03-31-2011 |
20110129416 | RECOMBINANT MONOCLONAL ANTIBODIES AND CORRESPONDING ANTIGENS FOR COLON AND PANCREATIC CANCERS - The present invention provides for recombinant monoclonal antibodies that bind to human colorectal and pancreatic carcinoma-associated antigens, along with nucleic acid sequences encoding the antibody chains, and the amino acid sequences corresponding to the nucleic acids, and uses for these antibodies, nucleic acids and amino acids. | 06-02-2011 |
Patent application number | Description | Published |
20100198712 | Certified Email System and Method - A certified email system for providing a time stamp for a presented file, particularly when the presented file is an email. Preferably a demanding party receives the email; generates a unique HASH; digitally signs the unique HASH; and sends the signed HASH and a time-stamp request call to a web services time-stamp conduit (WSTC). The WSTC receives the request and signed HASH from the demanding party and obtains a time stamp. The WSTC sends the time stamp back to the demanding party, which sends a time-stamp notification to the original sender of the email and, optionally, the recipient(s) of the email. Multiple branded or customized demanding servers can efficiently run using one web services time-stamp conduit. | 08-05-2010 |
20100324987 | Certified Email System and Method - A certified email system for providing a time stamp for a presented file, particularly when the presented file is an email. Preferably a demanding party receives the email; generates a unique HASH; digitally signs the unique HASH; and sends the signed HASH and a time-stamp request call to a web services time-stamp conduit (WSTC). The WSTC receives the request and signed HASH from the demanding party and obtains a time stamp. The WSTC sends the time stamp back to the demanding party, which sends a time-stamp notification to the original sender of the email and, optionally, the recipient(s) of the email. Multiple branded or customized demanding servers can efficiently run using one web services time-stamp conduit. | 12-23-2010 |
20100325005 | Certified Email System and Method - A certified email system for providing a time stamp for a presented file, particularly when the presented file is an email. Preferably a demanding party receives the email; generates a unique HASH; digitally signs the unique HASH; and sends the signed HASH and a time-stamp request call to a web services time-stamp conduit (WSTC). The WSTC receives the request and signed HASH from the demanding party and obtains a time stamp. The WSTC sends the time stamp back to the demanding party, which sends a time-stamp notification to the original sender of the email and, optionally, the recipient(s) of the email. Multiple branded or customized demanding servers can efficiently run using one web services time-stamp conduit. | 12-23-2010 |
20110270448 | Irrigation Controller and System Integrating No-Watering Restrictions and an Empirically-Derived Evapotranspiration Local Characteristic Curve - A convenient, easy-to-use, water-saving, and labor-saving FROG irrigation controller and system are provided, which determine the appropriate water budget and schedule for the property's landscaping based on evapotranspiration data for the geographic area, regulation data (mandated and voluntary watering restrictions), and property-specific data (such as type of plant, zone number, emitter type, and plant environment), with consideration given to reduction in watering days, increase in soil watering depth, and day of year. Once set, the FROG provides incremental adjustments over the course of the year; the homeowner no longer needs to re-set the watering program seasonally to comply with local mandated and voluntary watering restrictions. Compliance is automatic and obligatory, meeting the water saving goals of the local water authority. Optionally presented is a web-based wizard used to determine a customized water budget/schedule that is input into the FROG controller through a data storage unit or wireless input. | 11-03-2011 |
20130160092 | Certified Email System and Method - A certified email system for providing a time stamp for a presented file, particularly when the presented file is an email. Preferably a demanding party receives the email; generates a unique HASH; digitally signs the unique HASH; and sends the signed HASH and a time-stamp request call to a web services time-stamp conduit (WSTC). The WSTC receives the request and signed HASH from the demanding party and obtains a time stamp. The WSTC sends the time stamp back to the demanding party, which sends a time-stamp notification to the original sender of the email and, optionally, the recipient(s) of the email. Multiple branded or customized demanding servers can efficiently run using one web services time-stamp conduit. An integrated detailed billing system capable of pass-through client billing, keyword search functionality, a multi-party content management system, and convenient web-based automated verification (file or HASH) services are provided. | 06-20-2013 |
20140360898 | Combination Cell Phone and Eyeglass Case - A trim, compact combination case dedicated to storing a cell phone (or other small electronic device) and an accessible pair of eyeglasses is disclosed. The combination cell phone and eyeglass case includes a phone housing compartment and an adjacent eyeglass/storage compartment, which are configured to hold a cell phone and eyeglasses side by side. An aspect includes a transparent access window by which a user can view and contact the front touchscreen of an enclosed phone. The compact design allows the combination case to be easily carried in a bag, purse, briefcase or pocket. The combination case advantageously positions the eyeglasses oriented and located for quick retrieval when needed to view the phone screen or buttons. | 12-11-2014 |
Patent application number | Description | Published |
20140088770 | Irrigation Controller and System Integrating No-Watering Restrictions and an Empirically-Derived Evapotranspiration Local Characteristic Curve - A convenient, water-saving and labor-saving FROG irrigation controller and system are provided, which determine the appropriate water budget and schedule for the property's landscaping based on evapotranspiration data for the geographic area, regulation data (any mandated and voluntary watering restrictions), and property-specific data, with consideration given to reduction in watering days, increase in soil watering depth, and day of year. Once set, the FROG controller provides incremental adjustments over the course of the year; the homeowner no longer needs to re-set the watering program seasonally to comply with local mandated and voluntary watering restrictions. Compliance is automatic and obligatory, meeting the water saving goals of the local water authority. Optionally presented is a web-based wizard used to determine a customized water budget/schedule that is input into the FROG controller through a data storage unit or wireless input. | 03-27-2014 |
20150331404 | Irrigation Controller and System Integrating No-Watering Restrictions and an Empirically-Derived Evapotranspiration Local Characteristic Curve - A convenient, water-saving and labor-saving FROG irrigation controller and system are provided, which determine the appropriate water budget and schedule for the property's landscaping based on evapotranspiration data for the geographic area, regulation data (any mandated and voluntary watering restrictions), and property-specific data, with consideration given to reduction in watering days, increase in soil watering depth, and day of year. Once set, the FROG controller provides incremental adjustments over the course of the year; the homeowner no longer needs to re-set the watering program seasonally to comply with local mandated and voluntary watering restrictions. Compliance is automatic and obligatory, meeting the water saving goals of the local water authority. Optionally presented is a web-based wizard used to determine a customized water budget/schedule that is input into the FROG controller through a data storage unit or wireless input. | 11-19-2015 |