Patent application number | Description | Published |
20080312145 | Agent for Regulating Bone Formation - The present invention provides preventive, ameliorating, and/or therapeutic agents for diseases caused by a disturbed balance between bone formation and bone resorption. The decoys of the present invention induce normal bone metabolism by inhibiting the differentiation-inducing factors of cells involved in bone metabolism. For example, bone resorption can be controlled by using a decoy of the present invention to inhibit NF-κB, a transcriptional regulatory factor that regulates osteoclast differentiation. This method uses a mechanism different from those of previous pharmaceutical agents; therefore, one can expect it to be effective for cases in which existing pharmaceutical agents were not effective. | 12-18-2008 |
20090082411 | Pharmaceutical for prevention or treatment of bone metabolic disease - A method for treating a bone metabolic disease by administering to a human a pharmacologically effective amount of an angiotensin II receptor antagonist which is a compound of the following formula (I), a pharmacologically acceptable salt thereof or a pharmacologically acceptable ester thereof: | 03-26-2009 |
20100105762 | THERAPEUTIC AGENT FOR PERIODONTAL DISEASE AND ALVEOLAR BONE LOSS DUE TO SURGERY - By suppressing transcription activation by NFκB, the present invention was demonstrated to suppress alveolar bone resorption in periodontal disease models, and promote restoration of alveolar bone in periodontal disease-caused bone defect models. Therefore, the present invention provides agents for treating, preventing, and improving periodontal diseases and alveolar bone defects caused by surgical operations, said agents comprising as an active ingredient, a NFκB decoy or such that suppresses the transcription activity of NFκB. | 04-29-2010 |
20100311823 | AGENT FOR REGULATING BONE FORMATION - The present invention provides preventive, ameliorating, and/or therapeutic agents for diseases caused by a disturbed balance between bone formation and bone resorption. The decoys of the present invention induce normal bone metabolism by inhibiting the differentiation-inducing factors of cells involved in bone metabolism. For example, bone resorption can be controlled by using a decoy of the present invention to inhibit NF-κB, a transcriptional regulatory factor that regulates osteoclast differentiation. This method uses a mechanism different from those of previous pharmaceutical agents; therefore, one can expect it to be effective for cases in which existing pharmaceutical agents were not effective. | 12-09-2010 |
20110022027 | DRUG-ELUTING CATHETER AND METHOD OF MANUFACTURING THE SAME - Biocompatible nanoparticles | 01-27-2011 |
20110160132 | LYMPHANGIOGENESIS-PROMOTING AGENTS - Described herein is the discovery that HGFs activate the growth and migration of lymphatic endothelial cells and thereby promote lymphangiogenesis. The present invention is based on this finding, and provides lymphangiogenesis-promoting agents comprising as active ingredients HGFs, or proteins or compounds functionally equivalent thereto. Based on the finding described above, the present invention also provides methods for promoting lymphangiogenesis which comprise the step of locally administering HGFs or proteins functionally equivalent thereto to affected areas in patients with lymphedema. | 06-30-2011 |
20120046327 | METHOD FOR INHIBITING THE INDUCTION AND FORMATION OF OSTEOCLASTS - Methods for (i) inhibiting the induction and formation of osteoclasts, (ii) inhibiting RANKL expression in osteoblasts, (ii) inhibiting the activation of osteoclasts and (iv) inhibiting a decrease in bone density by administering to a warm-blooded animal in need thereof a pharmacologically effective amount of a compound selected from the group consisting of olmesartan and olmesartan medoxomil, a pharmacologically acceptable salt thereof or a pharmacologically acceptable ester thereof. | 02-23-2012 |
20140086944 | DNA VACCINE CONTAINING SPECIFIC EPITOPE OF APOLIPOPROTEIN (a) - The present invention provides an agent for the treatment or prophylaxis of arteriosclerosis comprising an expression vector encoding a chimeric Hepatitis B virus core antigen polypeptide inserted with an amino acid sequence containing a specific epitope of apolipoprotein (a), wherein the amino acid sequence containing the specific epitope is inserted between the amino acid residues 80 and 81 of the hepatitis B virus core antigen polypeptide. | 03-27-2014 |
20140099335 | DNA VACCINE - The present invention provides a therapeutic or improving agent for a lifestyle-related disease, containing an expression vector encoding a chimeric Hepatitis B virus core antigen polypeptide inserted with an amino acid sequence containing a specific epitope of the lifestyle-related disease-related factor, wherein the amino acid sequence containing the specific epitope is inserted between the amino acid residues 80 and 81 of the hepatitis B virus core antigen polypeptide. | 04-10-2014 |
20160101032 | PEPTIDE WITH ANTI-AGING EFFECT AND USE THEREOF - An object of the present invention to discover a short peptide having an anti-aging effect and to provide a novel anti-aging agent comprising the peptide as an active ingredient. The inventors have discovered that a peptide consisting of an amino acid sequence ELKLIFLHRLKRLRKRLKRK (SEQ ID NO: 1) or a partial sequence thereof and having one or more effects selected from the group consisting of promoting fibroblast growth, promoting hyaluronic acid production and contracting a collagen gel, or a derivative or salt of the peptide is useful as an active ingredient of an anti-aging agent. | 04-14-2016 |
Patent application number | Description | Published |
20120138379 | WORK VEHICLE - In a work vehicle, an engine compartment is disposed forwards of a cab. An exhaust gas treatment device is disposed over an engine in the engine compartment. A radiator is disposed forwards of the exhaust gas treatment device ( | 06-07-2012 |
20120241235 | WORK VEHICLE AND METHOD FOR CONTROLLING WORK VEHICLE - A controller of a work vehicle sets the upper limit of a fan target rotational speed in accordance with an engine rotational speed. The controller reduces an upper limit of the fan target rotational speed further when a lock-up clutch is in an engaged state than when the lock-up clutch is in a released state. | 09-27-2012 |
20140239625 | BULLDOZER - A bulldozer includes a cab, a fuel tank arranged to a rear of the cab, and first and second engaging members. The cab includes a driver seat and an air-conditioning cooling module projecting rearward from an upper end portion of the cab. The first and second engaging members are provided on the fuel tank, with each having an engaging part to engage onto a suspension member. The engaging part of the first engaging member is positioned on a first lateral side of a first straight line connecting a first lateral side end of the air-conditioning cooling module and a first lateral side end of the fuel tank. The engaging part of the second engaging member is positioned on a second lateral side of a second straight line connecting a second lateral side end of the air-conditioning cooling module, and a second lateral side end of the fuel tank. | 08-28-2014 |
20140290220 | ENGINE UNIT - An engine unit includes an engine, an exhaust gas treatment device and a connecting pipe. The engine has an exhaust gas port. The exhaust gas treatment device is arranged above the engine. The connecting pipe connects the exhaust gas port and the exhaust gas treatment device. The connecting pipe has an expandable-contractible bellows portion. The bellows portion has a linear form following the upward-downward direction. The lower end portion of the bellows portion is positioned lower than at least a part of the exhaust gas port. | 10-02-2014 |
20140290781 | EXHAUST GAS TREATMENT UNIT - An exhaust gas treatment unit includes an exhaust gas treatment device, a bracket and a connecting pipe. The exhaust gas treatment device is mounted on a bracket. The connecting pipe is connected to the exhaust gas treatment device. The connecting pipe directs exhaust gas to the exhaust gas treatment device. The connecting pipe may include a supporting portion and a pipe portion, with the supporting portion supporting the bracket and the pipe portion being integrated with the supporting portion. Alternatively, the exhaust gas treatment unit may further include a supporting member having a supporting portion supporting the bracket and a pipe portion integrated with the supporting portion, with the pipe portion connected to the connecting pipe. | 10-02-2014 |
20140291057 | BULLDOZER - In the engine compartment of a bulldozer the radiator is arranged forward of the engine. An exhaust gas treatment unit is arranged above the engine. A first exhaust gas treatment device of the exhaust gas treatment unit is arranged such that the longitudinal direction of the first exhaust gas treatment device follows the forward-backward direction of the vehicle. A second exhaust gas treatment device of the exhaust gas treatment unit is positioned to the side of the first exhaust gas treatment device, and arranged such that the longitudinal direction of the first exhaust gas treatment device follows the forward-backward direction of the vehicle. The air cleaner is arranged between the radiator and the exhaust gas treatment unit in the forward-backward direction of the vehicle. | 10-02-2014 |
20140291058 | BULLDOZER - A bulldozer includes an engine, first and second exhaust treatment apparatuses arranged above the engine, a relay connection pipe connecting the first and second apparatuses, and an engine hood covering upper parts of the first and second apparatuses. The relay connection pipe has a cylindrical shaped main section, a first section connecting the main section and the first apparatus, and a second section connecting the main section and the second apparatus. The lower end of the main section is positioned above upper ends of the first and second apparatuses. The upper surface of the hood has a convex section protruding above the relay connection pipe and a base section formed integrally with the convex section below the convex section. At least a portion of a line segment extending along the upper edge of the main section overlaps an upper surface part of the convex section in a bulldozer top view. | 10-02-2014 |
20140292033 | BULLZOZER - A bulldozer includes a cab and an engine hood. The cab has a foremost surface, and left and right front surfaces. The engine hood has an upper surface, left and right side surfaces, and flat first, second and third inclined surfaces. The first and second inclined surfaces contact the rear side of the upper surface and rear sides of the left and right side surfaces, and are inclined more obliquely to the right rear and left rear than the left and right side surfaces, respectively. The first, second and third inclined surfaces are inclined to face downward to the rear. The third inclined surface contacts the first and second inclined surfaces, and the upper surface. A window attached to the foremost surface is arranged in a vertical direction above first and second sides closest to the foremost surface out of sides constituting the first and second inclined surfaces, respectively. | 10-02-2014 |
20150078967 | EXHAUST TREATMENT UNIT AND WORK VEHICLE HAVING EXHAUST TREATMENT UNIT - An exhaust treatment unit for a work vehicle includes a selective catalytic reduction apparatus, a connection pipe, an ejection apparatus attached to the connection pipe, a first pipe section that guides coolant to the ejection apparatus, a second pipe section that discharges coolant from the ejection apparatus, first and second retaining sections, and a coolant pump. The ejection apparatus ejects reducing agent into exhaust supplied to the selective catalytic reduction apparatus. The first and second retaining sections retain coolant and are connected to the first and second pipe sections above the ejection apparatus, respectively. The coolant pump is driven by an engine driving force and supplies the coolant to the ejection apparatus via the first pipe section. The first and second pipe sections extend upward from first and second connecting sections of the first and second pipe sections and the ejection apparatus toward the first and second retaining sections, respectively. | 03-19-2015 |
Patent application number | Description | Published |
20160078650 | DRAWING DATA GENERATION DEVICE AND DRAWING DEVICE - A drawing data generation device performs an integration process on map data so as to integrate line data for drawing linear features such as roads, such that a drawing speed of a map image is improved. The line data is grouped by the line type and the line width. The integration process links thin solid lines L | 03-17-2016 |
20160098859 | 3D MAP DISPLAY SYSTEM - A three-dimensional map display system displays a three-dimensional map representing features thereon three-dimensionally. The system includes a map database, a projection view generation unit, and an attribute representation image superimposing unit. The map database stores drawing data including a three-dimensional model of a feature and appearance attribute information representing an appearance attribute of the feature, by associating the drawing data and the appearance attribute information with each other. The projection view generation unit generates a projection view by projecting the drawing data. The attribute representation image superimposing unit displays an attribute representation image by superimposing the attribute representation image on the projection view based on the appearance attribute information, where the attribute representation image includes a first attribute representation image representing the appearance of the feature according to the appearance attribute information, the first attribute representation image not being bound by a shape of the feature. | 04-07-2016 |
20160140756 | 3D MAP DISPLAY SYSTEM - A thee-dimensional (3D) map display system displays a 3D map on which a ground surface and a feature are represented three-dimensionally. The 3D map display system includes (a) a map database for storing map data representing a 3D shape of the ground surface and the feature, (b) a first drawing unit for drawing the ground surface and the feature by executing depth determination by referring to the map database, and (c) a second drawing unit for drawing a target feature, which is a feature in which at least a part thereof is hidden by a ground surface or other features in the drawing by the first drawing unit, by overwriting the target feature on a drawing result by the first drawing unit by using the map data without executing depth determination with respect to the drawing result by the first drawing unit. | 05-19-2016 |
Patent application number | Description | Published |
20080273718 | Bass enhancing method, signal processing device, and audio reproducing system - If the absolute value of the current sample is greater than or equal to an envelope value at the immediately preceding sample, an envelope value at the current sample is made greater than the envelope value at the immediately preceding sample. If the absolute value of the current sample is smaller than the envelope value at the immediately preceding sample and a count value C does not reach a predetermined number N, the count value C is incremented by one and the envelope value at the current sample is held at the envelope value at the immediately preceding sample. If the absolute value of the current sample is smaller than the envelope value at the immediately preceding sample and the count value C reaches the predetermined number N, the envelope value at the current sample is made smaller than the envelope value at the immediately preceding sample. | 11-06-2008 |
20080292114 | Audio reproducing apparatus - An audio signal processing apparatus includes a harmonic overtone adder and an equalizer. The harmonic overtone adder includes a high-pass filter for extracting from an audio signal higher than a first predetermined frequency, a filter for extracting a frequency component lower than half a second predetermined frequency, an harmonic overtone generator for generating a frequency-doubled harmonic overtone component from an output from the filter, and a first combining unit for combining the frequency component output from the high-pass filter and the harmonic overtone component output from the harmonic overtone generator. The equalizer includes a level detector for detecting a level of an overtone component contained in an output from the first combining unit, a gain controller for controlling dynamically the level of the harmonic overtone component contained in the output from the first combining unit, and a second combining unit for combining the output from the first combining unit with the harmonic overtone component. | 11-27-2008 |
20100316226 | SIGNAL PROCESSING APPARATUS AND SIGNAL PROCESSING METHOD - A signal processing apparatus includes: one or more detection means for detecting movement of a diaphragm of a speaker in correspondence with feedback methods that are different feedback methods; analog-to-digital conversion means for converting one or more detection signals acquired by the detection means into a digital form; feedback signal generating means for generating feedback signals corresponding to the feedback methods using the digital detection signals; synthesis means for combining an audio signal to be output as a driving signal of the speaker with the feedback signals; correction equalizer means for setting an equalizing characteristic to allow a sound reproduced by the speaker to have a target frequency characteristic by changing the digital audio signal; feedback operation setting means for setting feedback methods in which a feedback operation up to combining the audio signal with the feedback signal is performed and the feedback operation is not performed equalizing characteristic changing and setting means for changing the equalizing characteristic to be set by the correction equalizer means in accordance with a combination of the feedback methods. | 12-16-2010 |
20120140952 | AUDIO REPRODUCING APPARATUS - An audio signal processing apparatus and method for extracting components from an input signal, generating additional components, combining components, and level-controlling components. An audio signal processing apparatus may include a harmonic overtone adder and an equalizer. A harmonic overtone adder may include a high-pass filter, a low-pass filter, an harmonic overtone generator, and a combining unit. An equalizer may include a level detector and a gain controller. | 06-07-2012 |