Patent application number | Description | Published |
20080245163 | PENETRABLE CAP HAVING RIB STRUCTURES - A cap having a plurality of rib structures situated on an inner wall of the cap to facilitate the formation of air passageways as the cap is penetrated by a pipette tip. The air passageways aid in venting air from a fluid-holding vessel closed with the cap. | 10-09-2008 |
20080274514 | PENETRABLE CAP HAVING SPACED-APART GROOVES - A cap having a plurality of spaced-apart grooves in a downwardly tapered inner wall of the cap to facilitate the formation of air passageways as the cap is penetrated by a pipette tip. The air passageways aid in venting air from a fluid-holding vessel closed with the cap. | 11-06-2008 |
20080305010 | STRIATED CAP - A cap for use in forming a sealed container with a fluid-holding vessel. The cap includes a downwardly tapered inner wall having a plurality of radially extending striations for improving the penetrability of the cap and for facilitating the formation of air passageways. | 12-11-2008 |
20090098567 | COLLECTION DEVICE - A cap which can form an essentially leak-proof seal with an open-ended vessel capable of receiving and holding fluid specimens or other materials for analysis. To minimize potentially contaminating contact between a fluid sample present in the vessel and humans or the environment, the present invention features a cap having a frangible seal which is penetrable by a plastic pipette tip or other fluid transfer device. The cap further includes a filter for limiting dissemination of an aerosol or bubbles once the frangible seal has been pierced. The filter is positioned between the frangible seal and a retaining structure. The retaining structure is positioned on the cap above the filter and may be used to contain the filter within the cap. The material of the retaining structure may be penetrable by a fluid transfer device. | 04-16-2009 |
20090139992 | RECEPTACLES FOR STORING SUBSTANCES IN DIFFERENT PHYSICAL STATES - A receptacle having a plurality of interconnected chambers arranged to permit multiple process steps or processes to be performed independently or simultaneously. The receptacles are manufactured to separate liquid from dried reagents and to maintain the stability of the dried reagents. An immiscible liquid, such as an oil, is included to control loading of process materials, facilitate mixing and reconstitution of dried reagents, limit evaporation, control heating of reaction materials, concentrate solid support materials to prevent clogging of fluid connections, provide minimum volumes for fluid transfers, and to prevent process materials from sticking to chamber surfaces. The receptacles can be adapted for use in systems having a processing instrument that includes an actuator system for selectively moving fluid substances between chambers and a detector. The actuator system can be arranged to concentrate an analyte present in a sample. The detector can be used to detect an optical signal emitted by the contents of the receptacle. | 06-04-2009 |
20090208966 | METHOD FOR REMOVING A FLUID SUBSTANCE FROM A CLOSED SYSTEM - A cap which can form an essentially leak-proof seal with an open-ended vessel capable of receiving and holding fluid specimens or other materials for analysis. To minimize potentially contaminating contact between a fluid sample present in the vessel and humans or the environment, the present invention features a cap having a frangible seal which is penetrable by a plastic pipette tip or other fluid transfer device. The cap further includes a filter for limiting dissemination of an aerosol or bubbles once the frangible seal has been pierced. The filter is positioned between the frangible seal and a retaining structure. The retaining structure is positioned on the cap above the filter and may be used to contain the filter within the cap. The material of the retaining structure may be penetrable by a fluid transfer device. | 08-20-2009 |
20090301230 | METHOD FOR REMOVING A FLUID SUBSTANCE FROM A SEALED COLLECTION DEVICE - A method for removing a fluid substance from a sealed collection device comprising a cap and a fluid-holding vessel, where the method aids in venting air from the collection device when the cap is penetrated by a fluid transfer device used to withdraw a fluid substance from the vessel. Venting is aided by incorporating a pause step between penetrating the cap and contacting the fluid substance held by the vessel with the fluid transfer device or by contacting the cap at a slower speed than the fluid transfer device enters the collection device after the cap has been penetrated. | 12-10-2009 |
20100190215 | PENETRABLE CAP - A cap having a core structure dimensioned to receive a pipette therethrough. The cap includes two axially aligned frangible seals that are affixed to the core structure in a spaced-apart relationship. The frangible seals include a foil layer and are constructed so that air passageways are formed between the frangible seals and a pipette tip when the pipette tip penetrates the frangible seals. The cap optionally includes a filter interposed between the first and second frangible seals. | 07-29-2010 |
20100203547 | METHOD FOR ACCESSING THE CONTENTS OF A CLOSED VESSEL CONTAINING A SPECIMEN RETRIEVAL DEVICE - Method for obtaining a fluid from a collection device assembled to isolate a specimen retrieval device from the pathway of a fluid transfer device used to penetrate a cap of the collection device and to draw and remove the fluid from the collection device for analysis. | 08-12-2010 |
20100279276 | METHODS FOR DETERMINING THE PRESENCE OF SARS CORONAVIRUS IN A SAMPLE - Methods for determining the presence of SARS-CoV in a test sample that include targeting the SARS-CoV 5′ leader sequence or the SARS-CoV 3′ terminal sequence. | 11-04-2010 |
20110020824 | METHODS AND COMPOSITIONS FOR QUANTITATIVE AMPLIFICATION AND DETECTION OVER A WIDE DYNAMIC RANGE - Disclosed are compositions and methods for making differentiable amplicon species at unequal ratios using a single amplification system in a single vessel. The number of differentiable amplicons and their ratios to one another are chosen to span the required linear dynamic range for the amplification reaction and to accommodate limitations of the measuring system used to determine the amount of amplicon generated. Unequal amounts of distinguishable amplicon species are generated by providing unequal amounts of one or more amplification reaction components (e.g., distinguishable amplification oligomers, natural and unnatural NTP in an NTP mix, or the like). The amount of target nucleic acid present in a test sample is determined using the linear detection range generated from detection of one or more amplicon species having an amount within the dynamic range of detection. | 01-27-2011 |
20110076727 | PENETRABLE CAP - A cap having a core structure dimensioned to receive a pipette therethrough. The cap includes two axially aligned frangible seals that are affixed to the core structure in a spaced-apart relationship. The frangible seals are constructed so that air passageways are formed between the frangible seals and a pipette tip when the pipette tip penetrates the frangible seals. The cap optionally includes a filter interposed between the first and second frangible seals. | 03-31-2011 |
20110236888 | METHOD FOR ACCESSING THE CONTENTS OF A CLOSED VESSEL CONTAINING A SPECIMEN RETRIEVAL DEVICE - Method for obtaining a fluid from a collection device assembled to isolate a specimen retrieval device from the pathway of a fluid transfer device used to penetrate a cap of the collection device and to draw and remove the fluid from the collection device for analysis. | 09-29-2011 |
20120260951 | SOLUTIONS, METHODS AND KITS FOR DEACTIVATING NUCLEIC ACIDS - The present invention relates to reagents for use in deactivating nucleic acids and methods of making and using the same. | 10-18-2012 |
20130160574 | PENETRABLE CAP - A cap having a core structure dimensioned to receive a pipette therethrough. The cap includes two axially aligned frangible seals that are affixed to the core structure in a spaced-apart relationship. The frangible seals include a foil layer and are constructed so that air passageways are formed between the frangible seals and a pipette tip when the pipette tip penetrates the frangible seals. The cap optionally includes a filter interposed between the first and second frangible seals. | 06-27-2013 |
20140053662 | PENETRABLE CAP - A cap having a core structure dimensioned to receive a pipette therethrough. The cap includes two axially aligned frangible seals that are affixed to the core structure in a spaced-apart relationship. The frangible seals include a foil layer and are constructed so that air passageways are formed between the frangible seals and a pipette tip when the pipette tip penetrates the frangible seals. The cap optionally includes a filter interposed between the first and second frangible seals. | 02-27-2014 |
20140072974 | METHODS FOR QUANTITATIVE AMPLIFICATION AND DETECTION OVER A WIDE DYNAMIC RANGE - Disclosed are compositions and methods for making differentiable amplicon species at unequal ratios using a single amplification system in a single vessel. The number of differentiable amplicons and their ratios to one another are chosen to span the required linear dynamic range for the amplification reaction and to accommodate limitations of the measuring system used to determine the amount of amplicon generated. Unequal amounts of distinguishable amplicon species are generated by providing unequal amounts of one or more amplification reaction components (e.g., distinguishable amplification oligomers, natural and unnatural NTP in an NTP mix, or the like). The amount of target nucleic acid present in a test sample is determined using the linear detection range generated from detection of one or more amplicon species having an amount within the dynamic range of detection. | 03-13-2014 |
20140231710 | METHOD OF MAKING A FORMULATION FOR DEACTIVATING NUCLEIC ACIDS - The disclosure relates to formulations for use in deactivating nucleic acids and methods of making and using the same. | 08-21-2014 |