Patent application number | Description | Published |
20100249607 | QUANTITATIVE SPECTROSCOPIC IMAGING - The present invention relates to a fully quantitative spectroscopy imaging instrument for wide area detection of early cancer (dysplasia). This instrument provides quantitative maps of tissue biochemistry and morphology, making it a powerful surveillance tool for objective early cancer detection. The design, construction, calibration, and diagnostics applications of this system is described with the use of physical tissue models. Measurements were conducted on a resected colon adenoma, and the system can be used for vivo imaging in the oral cavity. | 09-30-2010 |
20120035442 | PORTABLE RAMAN DIAGNOSTIC SYSTEM - The present invention further relates to the selection of the specific filter combinations, which can provide sufficient information for multivariate calibration to extract accurate analyte concentrations in complex biological systems. The present invention also describes wavelength interval selection methods that give rise to the miniaturized designs. Finally, this invention presents a plurality of wavelength selection methods and miniaturized spectroscopic apparatus designs and the necessary tools to map from one domain (wavelength selection) to the other (design parameters). Such selection of informative spectral bands has a broad scope in miniaturizing any clinical diagnostic instruments which employ Raman spectroscopy in particular and other spectroscopic techniques in general. | 02-09-2012 |
20120259228 | TRI MODAL SPECTROSCOPIC IMAGING - The present invention relates to a spectroscopic imaging system using autofluorescence and reflectance images to diagnose tissue. A preferred embodiment of the invention uses a plurality of light sources to illuminate a tissue region to provide the fluorescence and reflectance images, respectively. | 10-11-2012 |
20120302892 | PORTABLE OPTICAL FIBER PROBE-BASED SPECTROSCOPIC SCANNER FOR RAPID CANCER DIAGNOSIS - A multimodal probe system for spectroscopic scanning of tissue for disease diagnosis. The system can use diffuse reflectance spectroscopy, fluorescence spectroscopy and Raman spectroscopy for the detection of cancerous tissue, such as tissue margin assessment. | 11-29-2012 |
20130265585 | SYSTEMS AND METHODS FOR PHASE MEASUREMENTS - Preferred embodiments of the present invention are directed to systems for phase measurement such as for imaging small biological objects with light. These embodiments can be applied to the fields of, for example, cellular physiology and neuroscience. These preferred embodiments are based on principles of phase measurements and imaging technologies. The scientific motivation for using phase measurements and imaging technologies is derived from, for example, cellular biology at the sub-micron level which can include, without limitation, imaging origins of dysplasia, cellular communication, neuronal transmission and implementation of the genetic code. Light based techniques with nanometer resolution enable the cellular machinery to be studied in its native state. Thus, preferred embodiments of the present invention include systems based on principles of interferometry and/or phase measurements and are used to study cellular physiology. These systems include principles of low coherence interferometry (LCI) using optical interferometers to measure phase, or light scattering spectroscopy (LSS) wherein interference within the cellular components themselves is used, or in the alternative the principles of LCI and LSS can be combined to result in systems of the present invention. | 10-10-2013 |
20140333929 | 3-D HOLOGRAPHIC IMAGING FLOW CYTOMETRY - Refractive index of biological specimens is a source of intrinsic contrast that can be explored without any concerns of photobleaching or harmful effects caused by extra contrast agents. This feature also contains rich information that can be related to the metabolism of cells at the cellular and subcellular levels. The present invention relates to systems and methods that can provide, without any moving parts, the 3-D refractive index map of continuously flowing biological samples in a micro-fluidic channel, for example. | 11-13-2014 |
20140349337 | RAMAN SPECTROSCOPY FOR DETECTION OF GLYCATED ANALYTES - The present invention relates to the optical measurement of blood analytes, such as glycated hemoglobin (HbA1c) and serum albumin as a functional metric of mean blood glucose in the diagnosis of diabetic patients. Non-enhanced Raman spectroscopy is employed as the analytical method for quantitative detection of blood analytes. Using processing techniques, non-enzymatic glycosylation (glycation) of the analytes results in measurable and highly reproducible changes in the acquired spectral data, which enable the accurate measurements and classification of glycated and unglycated analytes. | 11-27-2014 |
20140361148 | SYSTEM AND METHOD FOR HILBERT PHASE IMAGING - Hilbert phase microscopy (HPM) as an optical technique for measuring high transverse resolution quantitative phase images associated with optically transparent objects. Due to its single-shot nature, HPM is suitable for investigating rapid phenomena that take place in transparent structures such as biological cells. A preferred embodiment is used for measuring biological systems including measurements on red blood cells, while its ability to quantify dynamic processes on the millisecond scale, for example, can be illustrated with measurements on evaporating micron-size water droplets. | 12-11-2014 |
20150177133 | TOMOGRAPHIC PHASE MICROSCOPY - The present invention relates to systems and methods for quantitative three-dimensional mapping of refractive index in living or non-living cells, tissues, or organisms using a phase-shifting laser interferometric microscope with variable illumination angle. A preferred embodiment provides tomographic imaging of cells and multicellular organisms, and time-dependent changes in cell structure and the quantitative characterization of specimen-induced aberrations in high-resolution microscopy with multiple applications in tissue light scattering. | 06-25-2015 |
Patent application number | Description | Published |
20100094135 | SYSTEMS AND METHODS FOR PHASE MEASUREMENTS - Preferred embodiments of the present invention are directed to systems for phase measurement which address the problem of phase noise using combinations of a number of strategies including, but not limited to, common-path interferometry, phase referencing, active stabilization and differential measurement. Embodiment are directed to optical devices for imaging small biological objects with light. These embodiments can be applied to the fields of, for example, cellular physiology and neuroscience. These preferred embodiments are based on principles of phase measurements and imaging technologies. The scientific motivation for using phase measurements and imaging technologies is derived from, for example, cellular biology at the sub-micron level which can include, without limitation, imaging origins of dysplasia, cellular communication, neuronal transmission and implementation of the genetic code. The structure and dynamics of sub-cellular constituents cannot be currently studied in their native state using the existing methods and technologies including, for example, x-ray and neutron scattering. In contrast, light based techniques with nanometer resolution enable the cellular machinery to be studied in its native state. Thus, preferred embodiments of the present invention include systems based on principles of interferometry and/or phase measurements and are used to study cellular physiology. These systems include principles of low coherence interferometry (LCI) using optical interferometers to measure phase, or light scattering spectroscopy (LSS) wherein interference within the cellular components themselves is used, or in the alternative the principles of LCI and LSS can be combined to result in systems of the present invention. | 04-15-2010 |
Patent application number | Description | Published |
20100185937 | METHODS AND APPARATUS FOR CREATING MARKUP LANGUAGE DOCUMENTS - A method for generating markup language documents, e.g., XML documents, uses a code generator that creates programs configured to create dynamic XML documents at run time, avoiding many of the complexities arising from the use of conventional “XML GENERATE” statements. In one embodiment, this process involves (1) creating a template document using a markup language, wherein the template document includes a set of tags associated with the markup language documents; (2) parsing the template document to determine a working storage structure corresponding to the tags in the template document; and (3) generating an application program in the programming language (e.g., COBOL), wherein the application program includes a definition of the working storage structure, and is configured to generate, during run-time, a markup language document corresponding to the original template document. | 07-22-2010 |
20140149849 | METHODS AND APPARATUS FOR PROCESSING MARKUP LANGUAGE DOCUMENTS - A method for facilitating the processing of markup language documents, e.g., XML documents, uses a code generator that creates programs configured to read dynamic XML documents at run time, avoiding many of the complexities arising from the use of conventional “XML Parse” statements. In one embodiment, this process involves (1) creating a template document using the markup language, wherein the template document includes a set of tags associated with the markup language documents; (2) parsing the template document to determine a data structure corresponding to the tags in the template document; and (3) generating an application program in the programming language (e.g., COBOL), wherein the application program includes a definition of the data structure, and is configured to read, during run-time, the markup language document and generate a corresponding set of data elements corresponding to the data structure. | 05-29-2014 |
Patent application number | Description | Published |
20090177972 | WEB PAGE SECURITY SYSTEM - A security application for granting different access rights to web pages and objects on each web page is disclosed. A data table assigns one or more function identifiers (FIDs) to users. A second data table assigns a different object identifier (OID) to each web page, and to assign a different OID for each object on each web page. A third data table assigns an FID to each OID. When a user attempts to access a web page or an object on the web page, a web server compares each of the user's FIDs to the FID assigned to the web page or object. The web server grants access to the web page or object if one of the user's FIDs matches the FID assigned to the web page or object, the user is granted access to the web page or object according to the function of the matched FID. | 07-09-2009 |
20140082097 | METHOD, SYSTEM, AND COMPUTER PROGRAM PRODUCT FOR MERCHANT SERVICING - A method includes receiving a message comprising a user identification code via a social media messaging channel. In addition, the method includes receiving geo-location information of the device transmitting the message. The method also includes verifying the user identification code by confirming that the geo-location information complies with stored expected geo-location information. The method also includes accessing data associated with a transaction account linked to the user identification code based on the content of the message. The method further includes transmitting a reply to the received message on the social media messaging channel. | 03-20-2014 |
20140359716 | WEB PAGE SECURITY SYSTEM - A security application for granting different access rights to web pages and objects on each web page is disclosed. A data table assigns one or more function identifiers (FIDs) to users. A second data table assigns a different object identifier (OID) to each web page, and to assign a different OID for each object on each web page. A third data table assigns an FID to each OID. When a user attempts to access a web page or an object on the web page, a web server compares each of the user's FIDs to the FID assigned to the web page or object. The web server grants access to the web page or object if one of the user's FIDs matches the FID assigned to the web page or object, the user is granted access to the web page or object according to the function of the matched FID. | 12-04-2014 |
Patent application number | Description | Published |
20080275866 | DOMAIN INDEPENDENT SYSTEM AND METHOD OF AUTOMATING DATA AGGREGATION AND PRESENTATION - A domain independent system and method for automatically generating at least one presentation-ready report from either detailed or summarized data from database queries. The process of getting useful information requires querying a database to get detailed records, then meaningfully aggregating detailed data based on user experience and business needs and, finally, presenting the data using appropriate reports. This process of data aggregation and presentation can be automated and is accomplished by aggregating detailed data using domain metrics selected based on predefined and configurable rules or past usage; selecting one or more presentations based on predefined and configurable rules or past usage; and displaying one or more presentations based on device constraints and characteristics. | 11-06-2008 |
20110093501 | DOMAIN INDEPENDENT SYSTEM AND METHOD OF AUTOMATING DATA AGGREGATION - A computer automated method of presenting data. The method includes the steps of inputting a set of user-defined instructions into a computer database system, inputting a user query into said computer database system, mining the computer database system for data relevant to said user query, creating a data set comprising the data relevant to the user query, and selecting at least one presentation report for compiling the data, wherein the selection is based on any of predefined and configurable rules and past user usage. At least one presentation report is then displayed to the user, wherein the displaying process further includes the step of graphically arranging the at least one presentation report based on an available viewing area of a device accessing the at least one presentation report. | 04-21-2011 |
20110145253 | DOMAIN INDEPENDENT SYSTEM AND METHOD OF AUTOMATING DATA AGGREGATION - A computer automated method and system of presenting data. The method may include the steps of inputting a set of user-defined instructions into a remotely located computer database system via a public network connection, inputting a user query into the computer database system via the public network connection, mining the computer database system for data relevant to the user query, creating a data set comprising the data relevant to the user query, and aggregating data in the data set using domain metrics selected based on any of predefined and configurable rules and past user usage. The aggregation may further include tagging all data attributes in the data set based on database metadata and inputs from a user, wherein the data attributes comprise any of data identifications (IDs), data grouping attributes, and data measure attributes. | 06-16-2011 |
20110145254 | DOMAIN INDEPENDENT SYSTEM AND METHOD OF AUTOMATING DATA AGGREGATION - A computer automated method and system of presenting data. The method may include the steps of inputting a set of user-defined instructions into a remotely located computer database system via a local network connection, inputting a user query into the computer database system via the local network connection, mining the computer database system for data relevant to the user query, creating a data set comprising the data relevant to the user query, and aggregating data in the data set using domain metrics selected based on any of predefined and configurable rules and past user usage. The aggregation may further include tagging all data attributes in the data set based on database metadata and inputs from a user, wherein the data attributes comprise any of data identifications (IDs), data grouping attributes, and data measure attributes. | 06-16-2011 |
20110307477 | METHOD AND APPARATUS FOR DYNAMIC GROUPING OF UNSTRUCTURED CONTENT - A computer automated method and apparatus for aggregating unstructured content. The method includes the steps of defining a structured data set based upon unstructured content, storing the structured data set into the computer database system, inputting a set of user-defined instructions into a computer database system, inputting a user query including data attributes into the computer database system, mining the structured data set for data relevant to the user query, creating a results data set comprising the data relevant to the user query, and aggregating data in the results data set using domain metrics selected based on any of predefined and configurable rules and past user usage. | 12-15-2011 |