Patent application number | Description | Published |
20100153568 | METHODS, APPARATUSES, AND COMPUTER PROGRAM PRODUCTS FOR PROVIDING A LOCAL PROXY FOR ACCESSING WEB SERVICES - A method, apparatus, and computer program product are provided for providing a local proxy for accessing web services. An apparatus may include a processor configured to receive, at a proxy service implemented on the apparatus, a first HTTP request from a HTTP protocol client application executed on the apparatus. The first HTTP request may be directed to a first network location, wherein the HTTP client application is associated with the first network location. The processor may be further configured to determine whether the first HTTP request includes an indication of a second network location for circumventing a same-origin policy. The processor may additionally be configured to transmit a second HTTP request to the second network location when the first HTTP request includes an indication of a second network location. Corresponding methods and computer program products are also provided. | 06-17-2010 |
20100212004 | METHOD AND APPARATUS FOR PROVIDING ENHANCED SERVICE AUTHORIZATION - An approach is provided for authorizing one or more services from service providers in a communications network. The approach includes receiving a request from a first service provider, the request having an associated primary token and a secondary token identifier, the secondary token identifier relating to resources of a second service provider. Based, at least in part, on the secondary token identifier, a secondary token is identified; and then the secondary token is sent to the first service provider, wherein the first service provider and the second service provider belong to different trust domains and the first service provider can use the secondary token to access resources of the second service provider. | 08-19-2010 |
20100332332 | METHOD AND APPARATUS FOR FREELY DISTRIBUTING DIGITAL CONTENT WITH ADVERTISEMENT - An approach is provided for freely distributing digital content with advertisement. A digital content and advertising platform receives digital content and determines whether to permit free distribution of the digital content. The digital content and advertising platform then generates a digital medium to include the digital content, an advertisement, and a separation criterion for separating the advertisement from the digital content. | 12-30-2010 |
20100332834 | METHOD AND APPARATUS FOR PROVIDING A SCALABLE SERVICE PLATFORM USING A NETWORK CACHE - An approach is provided for building a scalable service platform by initiating transmission of encrypted data from a public network cache. An access control server platform determines a first authorization key for a user and a second authorization key for a resource, and then encrypts the resource with the second authorization key, and encrypts the second authorization key with the first authorization key. The access control server platform initiates distribution of the encrypted second authorization key with the encrypted resource over a network. The access control server platform further initiates caching the encrypted second authorization key with the encrypted resource that meets a predefined threshold value (e.g., a data size, an access frequency, a modification frequency, or an auditing requirement) in a cache in the network, and initiates transmission of the cached and encrypted second authorization key with the cached and encrypted resource from the cache to at least one authorized entity. | 12-30-2010 |
20110124319 | METHOD AND APPARATUS FOR ENSURING TRANSPORT OF USER AGENT INFORMATION - Techniques to ensure that user agent information is transported includes determining whether both a type field and a client platform information field are included in a first portion of a uniform resource locator field (URL) of a hypertext transfer protocol (HTTP) request message received from a remote client process. The first portion is different from a domain portion of the URL. The type field holds data that indicates whether the remote client inserted the client information field into a URL of an original HTTP request message. If both the type field and the client platform information field are included, then it is determined, based on data in the type field, whether to include both the type field and the client platform information field in a first portion of a URL in a link in a HTTP response message. The HTTP response message is sent to the remote client process. | 05-26-2011 |
20110161403 | METHOD AND APPARATUS FOR PROVIDING CLIENT-SIDE CACHING - An approach is provided for providing client-side caching in network communication. A client-side caching module receives a request, from a device, for a scripting file associated with web content, the scripting file supporting client-side caching at the device. The client-side caching module identifies that the request is received over a connection supporting connection reuse. The client-side caching module determines whether the request is a first-time request. If the request is a first time request, the client-side consistency module collects session configuration information for the web content from the device, specifies session variables in the scripting file based on the session configuration information, and initiates a subsequent request for the scripting file over the connection. If the request is a subsequent request, the client-side caching module marks the session variables in the scripting file as cacheable at the device, and causes, at least in part, transmission of the scripting file to the device. | 06-30-2011 |
20110161961 | METHOD AND APPARATUS FOR OPTIMIZED INFORMATION TRANSMISSION USING DEDICATED THREADS - An approach is provided for optimized information transmission using dedicated threads. A thread manager receives a request from a device for content information. The thread manager assigns the request to a worker thread for processing to generate the content information. The thread manager further determines whether the worker thread has completed the processing of the content information. The thread manager delegates the processed content information to a transmission thread based, at least in part, on the determination, wherein the transmission thread causes, at least in part, transfer of the processed content information. The thread manager releases the worker thread from the assigned request. | 06-30-2011 |
20110219127 | Method and Apparatus for Selecting Network Services - An approach is provided for selecting a network server. An apparatus comprising at least one processor, and at least one memory including computer program code, the at least one memory and the computer program code configured to, with the at least one processor, cause, at least in part, the apparatus to load from one or more network servers configuration information of one or more network servers used by a service provider network. The apparatus is also caused to select a network server in the service provider network based at least in part on at least one of network server latency and the network server load. The apparatus is further caused to set the network server as default network server used for at least one of current and future session on one or more user equipment. | 09-08-2011 |
20110264762 | Method and Apparatus for Handling Different Path Structures in Multiple CDN Vendors - An approach is provided for resolving a network address of one or more of items included in a request for web content based, at least in part, on location information. The network address of the items corresponds to at least one of a plurality of sources for retrieving the items. Resolving of the network address of the items is based at least in part on a persistent data element specifying pertinent location information. | 10-27-2011 |
20110270909 | METHOD AND APPARATUS FOR COORDINATING SERVICE INFORMATION ACROSS MULTIPLE SERVER NODES - An approach is provided for coordinating service information (e.g., account registration identifiers) across multiple server nodes. A server receives a request to register an identifier for an account. The server determines whether it is a home site for the identifier and processes the request based, at least in part, on the determination. | 11-03-2011 |
20120079570 | METHOD AND APPARATUS FOR ACCELERATED AUTHENTICATION - Techniques for accelerated authentication include receiving first data that indicates a first portion of user credentials for a first user but not a second portion. It is verified whether the first portion of user credentials is valid. If the first portion of user credentials is valid, then second data that indicates a valid value for the second portion of user credentials for the first user is sent. Other techniques include receiving first data that indicates a first portion of user credentials for a first user but not a second portion of user credentials for the first user. A first message that indicates the first portion of user credentials is sent to a remote process that initiates authentication of the first user based on the first portion of user credentials before receiving second data that indicates the second portion of user credentials for the first user. | 03-29-2012 |
20130060885 | METHOD AND APPARATUS FOR ENABLING OFFLINE WEB APPLICATION EXECUTION - An approach is provided for providing client-side caching of content using one or more web cookies. A data caching module determines a request from a device for specifying content data directed to at least one web server, at least one storage destination, or a combination thereof. The data caching module processes the content data for storage in one or more web cookies, then causes transmission of the content data via the one or more web cookies to the at least one web server, the at least one storage destination, or a combination thereof based on the request. | 03-07-2013 |
20130124680 | METHOD AND APPARATUS FOR ENSURING TRANSPORT OF USER AGENT INFORMATION - Techniques to ensure that user agent information is transported includes determining whether both a type field and a client platform information field are included in a first portion of a uniform resource locator field (URL) of a hypertext transfer protocol (HTTP) request message received from a remote client process. The first portion is different from a domain portion of the URL. The type field holds data that indicates whether the remote client inserted the client information field into a URL of an original HTTP request message. If both the type field and the client platform information field are included, then it is determined, based on data in the type field, whether to include both the type field and the client platform information field in a first portion of a URL in a link in a HTTP response message. The HTTP response message is sent to the remote client process. | 05-16-2013 |
20130145435 | METHOD AND APPARATUS FOR PROVIDING ENHANCED SERVICE AUTHORIZATION - An approach is provided for authorizing one or more services from service providers in a communications network. The approach includes receiving a request from a first service provider, the request having an associated primary token and a secondary token identifier, the secondary token identifier relating to resources of a second service provider. Based, at least in part, on the secondary token identifier, a secondary token is identified; and then the secondary token is sent to the first service provider, wherein the first service provider and the second service provider belong to different trust domains and the first service provider can use the secondary token to access resources of the second service provider. | 06-06-2013 |
20130254529 | METHOD AND APPARATUS FOR PROVIDING A SCALABLE SERVICE PLATFORM USING A NETWORK CACHE - An approach is provided for building a scalable service platform by initiating transmission of encrypted data from a public network cache. An access control server platform determines a first authorization key for a user and a second authorization key for a resource, and then encrypts the resource with the second authorization key, and encrypts the second authorization key with the first authorization key. The access control server platform initiates distribution of the encrypted second authorization key with the encrypted resource over a network. The access control server platform further initiates caching the encrypted second authorization key with the encrypted resource that meets a predefined threshold value (e.g., a data size, an access frequency, a modification frequency, or an auditing requirement) in a cache in the network, and initiates transmission of the cached and encrypted second authorization key with the cached and encrypted resource from the cache to at least one authorized entity. | 09-26-2013 |
Patent application number | Description | Published |
20100184661 | CONJUGATE COMPRISING ANGIOSTATION OR ITS FRAGMENT, THE METHOD FOR PRODUCING THE CONJUGATE AND USE THEREOF - The present invention provides an anti-tumor or anti-angiogenesis medicament, the combination or kit containing the medicament, and the method for producing the same. The anti-tumor or anti-angiogenesis medicament contains a conjugate comprising a modifying agent and the angiostatin or its fragments, wherein the conjugate exhibits prolonged in vivo half-life as compared to an unmodified angiostatin or its fragments. The modifying agent is selected from the group consisting of macromolecular polymers, protein molecules or fragments thereof, peptides, small molecules, or chemical substances of any other forms. | 07-22-2010 |
20120064078 | Novel Tumor Biomarket - The present invention relates to the diagnosis and treatment of cancer, and specifically to a method of diagnosing the presence or metastasis of cancer by detecting plasma Hsp90α having the amino acid sequence of SEQ ID No.1 as a tumor marker. In addition, the present invention also relates to a method for the treatment of cancer and metastasis. | 03-15-2012 |
20120165510 | NOVEL APPLICATION OF FIBRINOGEN-420 AND ITS ACTIVE DOMAIN - The invention discloses a novel application of fibrinogen-420 and its active domain (alpha EC domain), and a separate alpha EC domain protein has the same or similar function with fibrinogen-420. Fibrinogen-420 and its active domain can be widely used in inhibiting protein aggregation, helping protein refolding, drugs which can prevent and/or treat protein conformation disease, detecting denatured protein in quality control and protect protein from denaturation. | 06-28-2012 |
20130023479 | USE OF NUCLEOLIN AS A BIOMARKER FOR LYMPHANGIOGENESIS IN CANCER PROGNOSIS AND THERAPY - The present invention relates to a method of identifying cancer subjects, in particular human patients, who are suitable for anti-lymphangiogenesis therapy to prevent tumor growth and tumor metastasis. The present invention also relates to a new approach, which uses nucleolin as a bait to search and screen for lymphangiogenesis inhibitors or cancer suppressors, which function in a manner that is analogous to endostatin. The invention is based upon the discovery that nucleolin is specifically expressed on lymphangiogenic vessels and functions as a specific receptor for endostatin, and thus is involved in the signal transduction pathway of endostatin as an anti-lymphangiogenesis inhibitor. The present invention also discloses that cell surface nucleolin on lymphatic endothelial cells is a biomarker for lymphangiogenic vessels, which could be used for the prediction of tumor metastasis. | 01-24-2013 |
20130243757 | METHOD FOR CANCER DETECTION - The present invention relates to the diagnosis and treatment of cancer, and specifically to a method of diagnosing the presence, status or metastasis of cancer by detecting plasma Hsp90α having the amino acid sequence of SEQ ID NO:1 as a tumor marker. In addition, the present invention also relates to a method for the treatment of cancer and metastasis. | 09-19-2013 |
20140037655 | USE OF NUCLEOLIN AS A BIOMARKER FOR LYMPHANGIOGENESIS IN A CANCER PROGNOSIS AND THERAPY - The present invention relates to a method of identifying cancer subjects, in particular human patients, who are suitable for anti-lymphangiogenesis therapy to prevent tumor growth and tumor metastasis. The present invention also relates to a new approach, which uses nucleolin as a bait to search and screen for lymphangiogenesis inhibitors or cancer suppressors, which function in a manner that is analogous to endostatin. The invention is based upon the discovery that nucleolin is specifically expressed on lymphangiogenic vessels and functions as a specific receptor for endostatin, and thus is involved in the signal transduction pathway of endostatin as an anti-lymphangiogenesis inhibitor. The present invention also discloses that cell surface nucleolin on lymphatic endothelial cells is a biomarker for lymphangiogenic vessels, which could be used for the prediction of tumor metastasis. | 02-06-2014 |
20140056966 | CONJUGATE ANGIOSTATION OR ITS FRAGMENT, THE METHOD OF PRODUCING THE CONJUGATE AND USE THEREOF - The present invention provides an anti-tumor or anti-angiogenesis medicament, the combination or kit containing the medicament, and the method for producing the same. The anti-tumor or anti-angiogenesis medicament contains a conjugate comprising a modifying agent and the angiostatin or its fragments, wherein the conjugate exhibits prolonged in vivo half-life as compared to an unmodified angiostatin or its fragments. The modifying agent is selected from the group consisting of macromolecular polymers, protein molecules or fragments thereof, peptides, small molecules, or chemical substances of any other forms. | 02-27-2014 |
20140087441 | NOVEL APPLICATION OF FIBRINOGEN-420 AND ITS ACTIVE DOMAIN - The invention discloses a novel application of fibrinogen-420 and its active domain (alpha EC domain), and a separate alpha EC domain protein has the same or similar function with fibrinogen-420. Fibrinogen-420 and its active domain can be widely used in inhibiting protein aggregation, helping protein refolding, drugs which can prevent and/or treat protein conformation disease, detecting denatured protein in quality control and protect protein from denaturation. | 03-27-2014 |
20140147492 | METHODS AND COMPOSITIONS FOR ENHANCING THE UPTAKE OF THERAPEUTIC AGENTS BY TARGET CELLS - The present invention relates to a new use of a known medicament. Specifically, the invention relates to methods and compositions for enhancing the therapeutic efficacy of a therapeutic agent by increasing the uptake of the therapeutic agent by target cells, and in particular relates to a pharmaceutical composition comprising a regulating agent of lipid raft/caveolae-dependent endocytic pathway and some therapeutic agents, such as anti-tumor agents. The invention also relates to a method for screening a regulating agent of lipid raft/caveolae-dependent endocytic pathway capable of enhancing the therapeutic efficacy of anti-tumor agents. | 05-29-2014 |
20140193424 | METHOD AND MEDICAMENT FOR INHIBITING LYMPHANGIOGENESIS - The present invention provides a method for inhibiting lymphangiogenesis in a subject, comprising administering a therapeutically effective amount of a CXCR4 inhibitor and/or a CXCL12 inhibitor to the subject. The invention further provides a method for inhibiting tumor lymphatic metastasis in a cancer patient, comprising administering to the subject (a) a therapeutically effective amount of a CXCR4 inhibitor and/or a CXCL12 inhibitor, in combination with (b) a therapeutically effective amount of a VEGF-C inhibitor and/or a VEGF-D inhibitor and/or a VEGFR-3 inhibitor. | 07-10-2014 |
20140308263 | ENDOSTATIN MUTANTS WITH MUTATIONS AT ATP BINDING SITES - The present invention discloses a new anti-tumor medicament comprising a mutant of endostatin. The mutant comprises a mutation in the ATP-binding site of endostatin and has a decreased ATPase activity and an increased anti-angiogenesis activity. | 10-16-2014 |
20140335152 | METHODS AND COMPOSITIONS FOR ENHANCING THE UPTAKE OF THERAPEUTIC AGENTS BY TARGET CELLS - The present invention relates to a new use of a known medicament. Specifically, the invention relates to methods and compositions for enhancing the therapeutic efficacy of a therapeutic agent by increasing the uptake of the therapeutic agent by target cells, and in particular relates to a pharmaceutical composition comprising a regulating agent of lipid raft/caveolae-dependent endocytic pathway and some therapeutic agents, such as anti-tumor agents. The invention also relates to a method for screening a regulating agent of lipid raft/caveolae-dependent endocytic pathway capable of enhancing the therapeutic efficacy of anti-tumor agents. | 11-13-2014 |
Patent application number | Description | Published |
20090280085 | Long Acting Human Interferon Analogs - Compositions, kits and methods are provided for Interferon analogs in order to promote general health or for therapeutic treatment of diseases. Human interferon analogs are made by fusion of interferon with human serum albumin. The bio-assay shows that the interferon analogs with the same cell protection against viral attack have 3-10 times longer acting function than interferon in vivo. These novel long acting interferon analogs can be used in treatment of patients with viral infection, such as SARS virus, HIV, HCV, HBV, or HAV, and the cancer diseases, such as leukemia and malignant melanoma. They also have a 3-5 times longer shelf-life compared with interferon. | 11-12-2009 |
20100068173 | Recombinant Human Albumin-Interleukin-11 Fusion Protein With Long-Lasting Biological Effects - Compositions, kits and methods are provided for promoting general health or for prevention or treatment of diseases by using novel recombinant fusion proteins of human serum albumin (HSA) and bioactive molecules. The bioactive molecules may be a protein or peptide having a biological function in vitro or in vivo, and preferably, having a therapeutic activity when administered to a human. By fusing the bioactive molecule to HSA, stability of the bioactive molecule in vivo can be improved and the therapeutic index increased due to reduced toxicity and longer-lasting therapeutic effects in vivo. In addition, manufacturing processes are provided for efficient, cost-effective production of these recombinant proteins in yeast. | 03-18-2010 |
20120128624 | Recombinant Human Albumin-Granulocyte Macrophage Colony Stimulating Factor Fusion Protein With Long-Lasting Biological Effects - Compositions, kits and methods are provided for promoting general health or for prevention or treatment of diseases by using novel recombinant fusion proteins of human serum albumin (HSA) and bioactive molecules. The bioactive molecules may be a protein or peptide having a biological function in vitro or in vivo, and preferably, having a therapeutic activity when administered to a human. By fusing the bioactive molecule to HSA, stability of the bioactive molecule in vivo can be improved and the therapeutic index increased due to reduced toxicity and longer-lasting therapeutic effects in vivo. In addition, manufacturing processes are provided for efficient, cost-effective production of these recombinant proteins in yeast. | 05-24-2012 |
20140099270 | Method of Use and Preparation of HSA Fusion Protein Composition for Skincare - The present invention provides a recombinant fusion protein which stimulates the rejuvenation and reactivation of skin and epidermal cells for improving skin appearance, smoothing wrinkles and freckles, and whitening skin. Particularly, the present invention provides various types of products for improving skin, which contain recombinant fusion protein of human serum albumin (HSA) with cytokine peptides (EGF, FGF, KGF, HGH, HGF, PDGF, GCSF, interferon, IL- | 04-10-2014 |
Patent application number | Description | Published |
20110304619 | PRIMITIVE QUADRIC SURFACE EXTRACTION FROM UNORGANIZED POINT CLOUD DATA - A method, apparatus, system, article of manufacture, and data structure provide the ability to extract a primitive quadric surface from point cloud data. Point cloud data is obtained in 3D space. The point cloud data is segmented to create a disjoined surface and a smooth surface segment based on spatial connectivity and surface smoothness. One or more shapes are extracted from the point cloud data using geometric fitting. The geometric fitting searches for one or more quadric surface parameters of a given type of model that provides a best agreement between selected points from the point cloud data and a resultant model. | 12-15-2011 |
20110304628 | PIPE RECONSTRUCTION FROM UNORGANIZED POINT CLOUD DATA - A method, system, apparatus, article of manufacture, and computer readable storage medium provide the ability to reconstruct a pipe from point cloud data. Point cloud data is obtained. Primitive geometric shapes are detected in the point cloud data. A pipeline is determined by determining predecessor and successor primitive geometric shapes for each of the shapes. Diameters, coplanarity, and angles between the shapes are corrected. The shapes are connected and output. | 12-15-2011 |
20130218472 | SEGMENTATION OF GROUND-BASED LASER SCANNING POINTS FROM URBAN ENVIRONMENT - A method, apparatus, system, and article of manufacture provide object descriptors for objects in point cloud data for an urban environment by segmenting the point cloud data. Point cloud data for an urban environment is obtained using a ground-based laser scanner. Terrain points are filtered out from the point cloud data using ground filtering. The point cloud data is then segmented into two or more blocks. Objects that lie on neighboring adjacent blocks are combined. Object descriptors for the combined objects are then provided (e.g., to the user or a program used by the user). | 08-22-2013 |
20150063707 | OUTLINE APPROXIMATION FOR POINT CLOUD OF BUILDING - A method, apparatus, system, and computer program product provide the ability to model a polyline boundary from point cloud data. Point cloud data is obtained and boundary cells are extracted. Potential boundary points are filtered from the boundary cells. Line segments are extracted from the potential boundary points and refined. A regularized polygon is obtained by intersecting the refined line segments. | 03-05-2015 |