Patent application number | Description | Published |
20110212112 | CONFORMATION SPECIFIC ANTIBODIES - The disclosure provides, inter alia, binding proteins (e.g., antibodies) that bind to an integrin in an activated conformation, e.g., activated LFA-1 (“aLFA-1”), e.g., relative to a non-activated conformation of LFA-1. In one embodiment, the binding proteins inhibit at least one function of an aLFA-1, e.g., inhibit a binding interaction between aLFA-1 and a cognate ligand of aLFA-1, e.g., an ICAM protein. The binding proteins can be used to treat or prevent an inflammatory disorder or other disorder. | 09-01-2011 |
20140038842 | CELL SURFACE DISPLAY USING PDZ DOMAINS - Novel materials and methods useful for displaying polypeptides on the surface of a cell are provided, including cell surface proteins fused to a PDZ domain peptide and antibodies fused to PDZ-binding peptides. | 02-06-2014 |
Patent application number | Description | Published |
20090123871 | LITHOGRAPHIC IMAGING WITH PRINTING MEMBERS HAVING HYDROPHILIC, SURFACTANT-CONTAINING TOP LAYERS - Printing members that include a topmost layer comprising a polymer and a silicone surfactant are durable and enable use of low imaging-power densities. The protective layer may contain an inorganic crosslinker. | 05-14-2009 |
20100239976 | LITHOGRAPHIC IMAGING WITH PRINTING MEMBERS HAVING METAL IMAGING BILAYERS - Printing members include very thin metal imaging bilayers that combine to trap and utilize imaging radiation and, due to their minimal thicknesses, ablate easily. The bilayer may include a first (bottommost) metal layer having a high extinction coefficient in the imaging wavelength range (e.g., 600-1200 nm) and, thereover, a second metal layer having a high transmittance and low emissivity for imaging radiation. | 09-23-2010 |
20110188023 | LITHOGRAPHIC IMAGING AND PRINTING WITHOUT DEFECTS OF ELECTROSTATIC ORIGIN - Embodiments of the present invention involve three-layer printing members having a central layer that is non-conductive yet abalatable at commercially realistic fluence levels. In various embodiments, the central layer is polymeric with a dispersion of nonconductive carbon black particles therein at a loading level sufficient to provide at least partial layer ablatability and water compatibility of the resulting ablation debris. | 08-04-2011 |
20110249250 | ABLATION-TYPE LITHOGRAPHIC IMAGING WITH ENHANCED DEBRIS REMOVAL - Sequentially subjecting an imaged ablation-type printing member having a silicone topmost layer to, first, a cleaning liquid that is not a solvent for silicone, followed by subjecting to a second cleaning liquid that is a silicone solvent, conditions the printing member for subsequent printing with high-solids inks. | 10-13-2011 |
20110287266 | ABLATION-TYPE LITHOGRAPHIC IMAGING WITH SILICONE ACRYLATE LAYERS - In ablation-type printing plates involving silicone acrylate top layers, curing at high oxygen levels not only substantially reduces or eliminates toning, but does not adversely affect plate durability or printing performance. | 11-24-2011 |
20120097185 | PRESS CLEANING WITH LOW-VOC SOLVENT COMPOSITIONS - Low-VOC cleaning compositions effective in removing stubborn UV inks from printing-press components include at least one non-ionic surfactant selected from the group consisting of a sorbitan ester, an ethoxylated sorbitan ester, an ethoxylated castor oil, polyethylene glycol ester and an alcohol ethoxylate; and at least one carrier comprising or consisting essentially of at least one of (i) an organic solvent miscible therewith or (ii) D-limonene. The cleaning composition has a VOC limit less than 100 g/L. | 04-26-2012 |
20120156624 | WATERLESS PRINTING MEMBERS AND RELATED METHODS - In various embodiments, a recording medium comprises an oleophilic substrate and, thereover, a topmost oleophobic layer comprising a cured polymeric silicone matrix that consists essentially of the addition-cure reaction product of a vinyl-functional polydialkylsiloxane and a silane cross-linking agent. The vinyl-functional polydialkylsiloxane has a molecular weight ranging from 30,000 to 75,000 or 110,000 to 130,000. If the molecular weight of the vinyl-functional polydialkylsiloxane is within the range of 30,000 to 75,000, the molar ratio of silane groups to vinyl groups is within the range of about 11:1 to about 25:1; and if the molecular weight of the vinyl-functional polydialkylsiloxane is within the range of 110,000 to 130,000, the molar ratio of silane groups to vinyl groups is from about 5:1 to about 27:1. The recording medium may be used as a lithographic printing plate. | 06-21-2012 |
20120291643 | ABLATION-TYPE LITHOGRAPHIC PRINTING MEMBERS HAVING IMPROVED EXPOSURE SENSITIVITY AND RELATED METHODS - Ablation-type printing plates having improved exposure sensitivity are produced using an imaging layer—i.e., the plate layer that absorbs and ablates in response to imaging radiation—whose composition includes a large proportion of crosslinker. | 11-22-2012 |
20120291644 | ABLATION-TYPE LITHOGRAPHIC PRINTING MEMBERS HAVING IMPROVED EXPOSURE SENSITIVITY AND RELATED METHODS - Ablation-type printing plates having improved exposure sensitivity are produced using a thin imaging layer—i.e., the plate layer that absorbs and ablates in response to imaging radiation—whose composition includes a large proportion of radiation absorber. | 11-22-2012 |
20120291645 | ABLATION-TYPE LITHOGRAPHIC PRINTING MEMBERS HAVING IMPROVED EXPOSURE SENSITIVITY AND RELATED METHODS - Ablation-type printing plates having improved exposure sensitivity are produced using an imaging layer—i.e., the plate layer that absorbs and ablates in response to imaging radiation—whose composition includes a large proportion of crosslinker. | 11-22-2012 |
20120312183 | ABLATION-TYPE LITHOGRAPHIC PRINTING MEMBERS HAVING IMPROVED SHELF LIFE AND RELATED METHODS - Ablation-type printing plates having increased shelf-life are produced using a melamine resin free of water prior to use. A representative production sequence includes providing a substrate having an oleophilic surface; coating, over the substrate, an oleophilic resin composition having (A) a resin phase consisting essentially of a melamine resin substantially free of water and a resole resin, the resole resin being present in an amount ranging from 0% to 28% by weight of dry film, (B) a near-IR absorber dispersed within the resin phase, and (C) a sulfonic acid catalyst dispersed within the resin phase and being present in an amount ranging from 0.7% to 1.6% by weight of dry film; curing the resin composition to produce a dry film; following resin curing, coating an oleophobic polymer composition over the cured resin composition; and curing the oleophobic polymer composition. | 12-13-2012 |
20130160667 | LITHOGRAPHIC IMAGING AND PRINTING WITHOUT DEFECTS OF ELECTROSTATIC ORIGIN - Embodiments of the present invention involve three-layer printing members having a central layer that is non-conductive yet abalatable at commercially realistic fluence levels. In various embodiments, the central layer is polymeric with a dispersion of nonconductive carbon black particles therein at a loading level sufficient to provide at least partial layer ablatability and water compatibility of the resulting ablation debris. | 06-27-2013 |
20130298793 | ABLATION-TYPE LITHOGRAPHIC IMAGING WITH SILICONE ACRYLATE LAYERS - In ablation-type printing plates involving silicone acrylate top layers, curing at high oxygen levels not only substantially reduces or eliminates toning, but does not adversely affect plate durability or printing performance. | 11-14-2013 |