Patent application number | Description | Published |
20100016137 | PROCESS OF MANUFACTURING SEALED PACKAGES CONTAINING A POURABLE FOOD PRODUCT AND PACKAGING EQUIPMENT FOR PERFORMING SUCH PROCESS - A process of manufacturing sealed packages containing a pourable food product from a web packaging material moving along a predetermined path involves providing a recurring pattern of printed register marks on the web packaging material, applying a recurring pattern of bend or fold lines on the web packaging material as a function of the detected position of the printed register marks, generating new references, distinct from the bend or fold lines, on the web packaging material in a synchronized way with the application of the recurring pattern of bend or fold lines; and performing one or more subsequent operations on the web packaging material based on a synchronization pulse created by detection of the new references. | 01-21-2010 |
20100257987 | METHOD FOR CONTROLLING THE REGISTER BETWEEN A PRINTED PATTERN AND A THREE-DIMENSIONAL PATTERN ON A PACKAGING MATERIAL - A method and/or an apparatus for controlling the register between print and three-dimensional structures, such as creases in the forming of a package, and a method and/or the apparatus for controlling a unit for repeated cutting-out or perforation of a material web from which the packages are formed. In the control, a focused, high intensive light beam, such as a laser line, is laid in a bisecting direction to relevant creases. The position of the crease or the creases is determined by sensing of a deflection of the projected laser line. Diffuse light from the laser line may be used in order to register the position of a register marking. If the difference between the register marking and crease differs more than a predetermined value, the creasing tool and/or printing press is automatically adjusted. | 10-14-2010 |
20120138634 | SHEET PACKAGING MATERIAL FOR PRODUCING SEALED PACKAGES OF POURABLE FOOD PRODUCTS - A sheet packaging material for producing a sealed package of a pourable food product comprises one base layer, a number of lamination layers covering both sides of the base layer, and a removable portion which, in use, can be detached partly from the rest of the packaging material along at least one arc-shaped cutting line and folded at a folding zone extending between opposite ends of the cutting line to free a pour opening; the removable portion comprises a central area made of whole packaging material and which, in use, remains attached to the rest of the packaging material through a permanent bridge defined by the folding zone, and a peripheral area for cutting interaction, extending around part of the central area, containing the cutting line and including at least one pre-laminated opening formed by a through slot at least in the base layer and covered by one or more of the lamination layers. | 06-07-2012 |
Patent application number | Description | Published |
20090099126 | Ribonucleoside Cyclic Acetal Derivatives for the Treatment of RNA-Dependent RNA Viral Infection - The present invention provides ribonucleoside 2′,3′-cyclic acetals of structural formula I which are precursors or prodrugs of inhibitors of RNA-dependent RNA viral polymerase. These compounds are precursors of inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as pre-cursors or prodrugs of inhibitors of hepatitis C virus (HCV) NS5B polymerase, as precursors or prodrugs of inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such ribonucleoside 2′,3′-cyclic acetals alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the ribonucleoside 2′,3′-cyclic acetals of the present invention. | 04-16-2009 |
20120252027 | Method For Rapidly Evaluating Performance Of Short Interfering RNA With Novel Chemical Modifications - It is an object of the instant invention to provide a method for the rapid evaluation of novel sugar modifications to be used in siRNA synthesis including the rapid evaluation of chemical modification patterns within the siRNA to effectuate increased stability and ultimately increased efficacy of a siRNA therapeutic. It is a further object of the instant invention to provide novel nucleosides useful for siRNA therapy. | 10-04-2012 |
20150299243 | 2'-ALKYNYL SUBSTITUTED NUCLEOSIDE DERIVATIVES AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES - The present invention relates to 2′-Alkynyl Substituted Nucleoside Derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein B, X, R1, R2, R3 and R4 are as defined herein. The present invention also relates to compositions comprising at least one 2′-Alkynyl Substituted Nucleoside Derivative, and methods of using the 2′-Alkynyl Substituted Nucleoside Derivatives for treating or preventing HCV infection in a patient. | 10-22-2015 |
20150315221 | NUCLEOSIDE KINASE BYPASS COMPOSITIONS AND METHODS - The present invention relates to disulfide masked prodrug compounds, compositions and methods that are amenable to bioactivation by a reducing agent such as glutathione. Such disulfide based compounds, compositions, and methods can be useful, for example, in providing novel prodrugs for use as therapeutics. | 11-05-2015 |
20150315226 | DISULFIDE MASKED PRODRUG COMPOSITIONS AND METHODS - The present invention relates to disulfide masked prodrug compounds, compositions and methods that are amenable to bioactivation by a reducing agent such as glutathione. Such disulfide based compounds, compositions, and methods can be useful, for example, in providing novel prodrugs for use as therapeutics. | 11-05-2015 |
Patent application number | Description | Published |
20090106415 | Display of Person Based Information Including Person Notes - Among other disclosures, a method may include collecting historical communication data and personal data relating to a portion of a plurality of communications, a sender of one or more of the communications or one or more recipients of the communications. The method may include generating a profile based on the collected historical communication data and personal data. The method may include receiving user input and incorporating the user input into the profile. The method may include presenting the profile including the user input in response to user behavior. | 04-23-2009 |
20130023243 | SENDING MESSAGES FROM A COMPUTING DEVICE - Systems include configuring a first mobile device to enable communication between the first mobile device and one or more processing devices; receiving a message from a computing device that is directed to a second mobile device, where the message is a text message or a voice message, and where the computing device is different from the first mobile device; and routing the message to the first mobile device for transmission to the second mobile device from the first mobile device. | 01-24-2013 |
20130198277 | EXPERIENCE SHARING SYSTEM AND METHOD - User commentary concerning a user experience is received and a user experience data card is generated for the user experience based, at least in part, upon the user commentary. The user experience data card is stored, wherein the stored user experience data card corresponds to a first view of the user experience data card and receiving a request for an experience data card from a second user. The user experience data card is provided to the second user at least in part based on the request received from the second user and receiving feedback from the second user concerning the user experience data card. A second view of the user experience data card is generated based, at least in part, upon the feedback from the second user, wherein the second view of the user experience data card is distinct form the first view of the experience data card. | 08-01-2013 |
20150317343 | FACILITATING CROSS-PLATFORM CONTENT ACCESS - A messaging system includes features of gathering information regarding content accessed across multiple applications and/or devices and making that information available to account holders of the messaging system. The messaging system stores data related to accessed content in a plurality of indices and makes that data available to enable account holders to access previously-accessed content, even if the previous access occurred in a different software application, on a different device, or on a device with a different operating system. Account holders may also be provided with recommendations based on gathered information. | 11-05-2015 |
Patent application number | Description | Published |
20080301683 | Performing an Allreduce Operation Using Shared Memory - Methods, apparatus, and products are disclosed for performing an allreduce operation using shared memory that include: receiving, by at least one of a plurality of processing cores on a compute node, an instruction to perform an allreduce operation; establishing, by the core that received the instruction, a job status object for specifying a plurality of shared memory allreduce work units, the plurality of shared memory allreduce work units together performing the allreduce operation on the compute node; determining, by an available core on the compute node, a next shared memory allreduce work unit in the job status object; and performing, by that available core on the compute node, that next shared memory allreduce work unit. | 12-04-2008 |
20090006810 | MECHANISM TO SUPPORT GENERIC COLLECTIVE COMMUNICATION ACROSS A VARIETY OF PROGRAMMING MODELS - A system and method for supporting collective communications on a plurality of processors that use different parallel programming paradigms, in one aspect, may comprise a schedule defining one or more tasks in a collective operation an executor that executes the task, a multisend module to perform one or more data transfer functions associated with the tasks, and a connection manager that controls one or more connections and identifies an available connection. The multisend module uses the available connection in performing the one or more data transfer functions. A plurality of processors that use different parallel programming paradigms can use a common implementation of the schedule module, the executor module, the connection manager and the multisend module via a language adaptor specific to a parallel programming paradigm implemented on a processor. | 01-01-2009 |
20120179881 | Performing An Allreduce Operation Using Shared Memory - Methods, apparatus, and products are disclosed for performing an allreduce operation using shared memory that include: receiving, by at least one of a plurality of processing cores on a compute node, an instruction to perform an allreduce operation; establishing, by the core that received the instruction, a job status object for specifying a plurality of shared memory allreduce work units, the plurality of shared memory allreduce work units together performing the allreduce operation on the compute node; determining, by an available core on the compute node, a next shared memory allreduce work unit in the job status object; and performing, by that available core on the compute node, that next shared memory allreduce work unit. | 07-12-2012 |
Patent application number | Description | Published |
20090193390 | TECHNIQUES FOR MODELING VARIABLES IN SUBPROGRAMS OF HARDWARE DESCRIPTION LANGUAGE PROGRAMS - A method, system and computer program product for modeling variables in subprograms of a HDL program. A subprogram is provided with an initial value of a variable of an element being modeled and the subprogram is stored in memory of a data processing system. In response to a subprogram call, a copy of the stored subprogram is provided to the requesting HDL program. During execution, the initial value of the variable in the provided copy of the subprogram may be modified by the HDL program, but the value retains unchanged in the stored subprogram. | 07-30-2009 |
20130275930 | SYNTHESIZING VHDL MULTIPLE WAIT FSMS INTO RT LEVEL FSMS BY PREPROCESSING - Preprocessing parallel sequences of “wait” statements and synthesizing these multiple “wait” statements to construct support for RTL tools. This is accomplished by preprocessing a VHDL process with multiple wait statements (referred to as BehFSM) into an equivalent register transfer. | 10-17-2013 |
20150161309 | GLITCH-AWARE PHASE ALGEBRA FOR CLOCK ANALYSIS - A design tool can implement phase algebra based design evaluation to evaluate a circuit design with a compact representation of numerous waveforms without simulating the individual waveforms. The design tool can determine an input sequence of signal transition representations associated with an input net of a component in a register transfer level circuit design, where each signal transition representation represents a nondeterministic transition from a previous signal state to one or more possible signal states. Determining the input sequence of signal transition representations includes determining that a subsequence of the input sequence of signal transition representations indicates at most one transition within the subsequence of the input sequence. The design tool can determine, based on the indicated component and on the determination that the subsequence indicates at most one transition, an output sequence of signal transition representations derived from the input sequence of signal transition representations. | 06-11-2015 |
20150161310 | CLOCK-GATING PHASE ALGEBRA FOR CLOCK ANALYSIS - A design tool can implement phase algebra based design evaluation to evaluate a circuit design with a compact representation of numerous waveforms without simulating the individual waveforms. The design tool can determine an input sequence of signal transition representations associated with an input net of a component in RTL circuit design, where each signal transition representation represents a nondeterministic transition from a previous signal state to possible signal state(s). Determining the input sequence of signal transition representations includes determining that the input sequence of signal transition representations indicates an input gated clock waveform. The design tool also can determine, based on the indicated component and on the input gated clock waveform, an output sequence of signal transition representations derived from the input sequence of signal transition. Determining the output sequence includes determining whether signal transition representation(s) of the output sequence indicate an output gated clock waveform. | 06-11-2015 |
20150161311 | CONDITIONAL PHASE ALGEBRA FOR CLOCK ANALYSIS - A design tool can implement phase algebra based design evaluation to evaluate a circuit design with a compact representation of numerous waveforms without simulating the individual waveforms. The design tool can determine two or more input sequences of signal transition representations associated with an input net of an indicated component in an RTL circuit design, where the two or more input sequences of signal transition representations are associated with a mode element. Each signal transition representation represents a nondeterministic transition from a previous signal state to possible signal state(s). The mode element indicates a selection between two or more output sequences of signal transition representations. It is determined, based on the indicated component and the mode element, two or more output sequences of signal transition representations derived from the input sequence(s) of signal transition representations. | 06-11-2015 |
20150161312 | STATIC CHECKING OF ASYNCHRONOUS CLOCK DOMAIN CROSSINGS - A circuit design checker receives a circuit design. The circuit design can include a first set of one or more logic components in a first clock domain and a second set of one or more logic components in a second clock domain. The clock domain checker identifies a first subset of the second set of one or more logic components that receive one or more asynchronous clock domain crossings. The circuit design is traversed to determine whether a subset of the one or more asynchronous clock domain crossings does not pass through a signal having an attribute indicating that the signal is intended to be part of the one or more asynchronous clock domain crossings. If such a crossing exists, an error is indicated for the circuit design. | 06-11-2015 |
20150161313 | CIRCUIT DESIGN EVALUATION WITH COMPACT MULTI-WAVEFORM REPRESENTATIONS - A design tool can implement phase algebra based design evaluation to efficiently evaluate a circuit design with a compact representation of numerous waveforms without simulating the individual waveforms. Instead of individual waveforms, the phase algebra based design evaluation employs compact representations of a group or set of waveforms. Phase algebra based evaluation constructs representations of a set of waveforms based on relationships among a devised set of functions that account for the various states of a signal over time, including transitions and glitches. A memorized-transition function, referred to herein as an M-function, indicates signal transitions over time. | 06-11-2015 |
20150269296 | STATIC CHECKING OF ASYNCHRONOUS CLOCK DOMAIN CROSSINGS - A circuit design checker receives a circuit design. The circuit design can include a first set of one or more logic components in a first clock domain and a second set of one or more logic components in a second clock domain. The clock domain checker identifies a first subset of the second set of one or more logic components that receive one or more asynchronous clock domain crossings. The circuit design is traversed to determine whether a subset of the one or more asynchronous clock domain crossings does not pass through a signal having an attribute indicating that the signal is intended to be part of the one or more asynchronous clock domain crossings. If such a crossing exists, an error is indicated for the circuit design. | 09-24-2015 |
20150269299 | PHASE ALGEBRA FOR ANALYSIS OF HIERARCHICAL DESIGNS - A design tool can implement phase algebra based design evaluation to evaluate a circuit design with a compact representation of waveforms without simulating the individual waveforms. The tool can determine whether module instances of a register level circuit design share a common usage, each instance being associated with a mapping. Two instances share a common usage if a sequence of signal transition representations received by the first instance can be mapped using a first mapping to the same common sequence of signal transition representations as a mapping of another sequence of signal transition representations received by the second instance using a second mapping. A result sequence of signal transition representations was generated by a previous propagation of the common sequence through the common usage. If the two instances share the common usage, the result sequence is mapped to an output sequence for the second instance using the second mapping. | 09-24-2015 |
Patent application number | Description | Published |
20100189113 | LINK FAILURE RECOVERY METHOD AND APPARATUS - A method of routing packets across a packet switched network domain, comprising a multiplicity of nodes. Each node comprises an ingress interface and an egress interface. For each destination node a default and a detour branching are defined, each specifying a route to the destination node. For each two-edge connected node the default and detour branchings do not share a common ingress interface. Each node operates as an intermediate node receiving a packet at an ingress interface, identifying an egress interface based upon the ingress interface upon which the packet is received and the packet destination, forwarding the packet via that egress interface if the connected link is available and, if the connected link is not available, forwarding the packet via an alternative egress interface associated with said detour branching if the packet was received at an ingress interface associated with said default branching or dropping the packet if the packet was received at an ingress interface associated with said detour branching. | 07-29-2010 |
20120039164 | System And Method Of Implementing Lightweight Not-Via IP Fast Reroutes In A Telecommunications Network - A system, method, and node for implementing lightweight Not-via Internet Protocol fast reroutes of a packet in a telecommunications network between a first node and a destination node. The method determines a shortest path between the first node and the destination node and two redundant trees between the first node and the destination node. Each redundant tree provides an alternate path from the first node and the destination node. When a failure in a link between the first node and the destination node is detected, the packet is forwarded to the destination node via a first redundant tree, and if not available, via a second redundant tree. If the second redundant tree is not available, the packet is dropped. If no failure in the link between the first node and the destination node is detected, the packet is sent via the determined shortest path to the destination node. | 02-16-2012 |
Patent application number | Description | Published |
20080233006 | Method and Apparatus For Determining the Oxygen Permeability of a Polymer - The present invention is relates to an apparatus and method for the determination of the oxygen gas permeability of a polymer. In one embodiment, the present invention relates to an apparatus and method for determining the oxygen gas permeability of a polymer membrane (e.g., a polydimethylsiloxane and/or polysiloxane polymer or copolymer). In still another embodiment, the present invention relates to oxygen gas permeable polymer compositions. | 09-25-2008 |
20100048818 | AMPHIPHILIC GRAFTS AND CO-NETWORKS AND PROCESS FOR MAKING SAME - The present invention generally relates to amphiphilic grafts and co-networks made from at least one hydrophilic polymer and at least one hydrophobic polymer, and to processes for preparing such amphiphilic grafts and co-networks. In another embodiment, the present invention relates to amphiphilic co-networks formed from the combination of at least one polysiloxane and at least one polyacrylamide. In yet another embodiment, the present invention relates to amphiphilic co-networks formed from the combination of at least one polysiloxane, at least one polyacrylamide and at least one crosslinking agent. | 02-25-2010 |
20100209468 | IMPLANTABLE DEVICES FOR PRODUCING INSULIN - The present invention generally relates to implantable devices for producing insulin in diabetic animals. Some embodiments include amphiphilic biomembranes for use in biological applications (e.g., as an alternative and/or supplemental insulin source). Some embodiments also include live insulin-producing cells contained within one or more amphiphilic membranes so as to prevent or diminish an immuno-response and/or rejection by the host. | 08-19-2010 |
Patent application number | Description | Published |
20100150984 | BIO-ARTIFICIAL PANCREAS AND A PROCEDURE FOR PREPARATION OF SAME - The present invention generally relates to implantable devices for producing insulin in diabetic animals and to methods of making same. Some embodiments include amphiphilic biomembranes for use in biological applications (e.g., as an alternative and/or supplemental insulin source). Some embodiments also include live insulin-producing cells contained within one or more amphiphilic membranes so as to prevent or diminish an immuno-response and/or rejection by the host. | 06-17-2010 |
20100267897 | THERMOPLASTIC AMPHIPHILIC CO-NETWORKS - The present invention relates generally to thermoplastic amphiphilic networks and/or co-networks. In one embodiment, the present invention relates to thermoplastic (TP) amphiphilic co-networks (APCNs) and the preparation of membranes from such APCNs. In another embodiment, the present invention relates to an amphiphilic network comprising at least one hydrophilic polymer-derived portion, at least one hydrophobic polymer-derived portion and at least one thermoplastic polymer-derived portion. In still another embodiment, the present invention relates to thermoplastic amphiphilic co-networks prepared by combining the chemistries of APCNs and polyurethanes (PUs) and to the preparation of membranes therefrom. | 10-21-2010 |
20110213084 | POLYMERS HAVING BOTH HARD AND SOFT SEGMENTS, AND PROCESS FOR MAKING SAME - The present invention generally relates to alcohol- and amine-terminated polyisobutylene (PIB) compounds, and to a process for making such compounds. In one embodiment, the present invention relates to primary alcohol- and amine-terminated polyisobutylene compounds, and to a process for making such compounds. In still another embodiment, the present invention relates to polyisobutylene compounds that can be used to synthesize polyurethanes and polyureas, to polyurethane and polyurea compounds made via the use of such polyisobutylene compounds, and to processes for making such compounds. In yet another embodiment, the present invention relates to polyisobutylene compounds containing urea or urethane segments therein, and to a method of producing such compounds. In still yet another embodiment, the present invention relates to a polymer having one or more different soft segments and one or more different hard segments. | 09-01-2011 |
20120259069 | POLYISOBUTYLENE-BASED POLYURETHANES, POLYUREAS AND/OR POLYURETHANE-POLYUREAS AND METHOD FOR MAKING SAME - The present invention generally relates to polyisobutylene-based polyurethanes, polyureas and/or polyurethane-polyureas, and to a process for making such compounds. In one embodiment, the polyisobutylene-based polyurethanes, polyureas and/or polyurethane-polyureas also include at least one flexible hydrogen bond acceptor chain extender (HACE). In another embodiment, amine telechelic and hydroxyl telechelic polyisobutylenes are utilized with at least one at least one flexible hydrogen bond acceptor chain extender (HACE) to produce polyurethane-polyureas having various desired mechanical properties in combination with various desired oxidative/hydrolytic stability. | 10-11-2012 |
20130041108 | POLYMERS HAVING BOTH HARD AND SOFT SEGMENTS, AND PROCESS FOR MAKING SAME - The present invention generally relates to alcohol- and amine-terminated polyisobutylene (PIB) compounds, and to a process for making such compounds. In one embodiment, the present invention relates to primary alcohol- and amine-terminated polyisobutylene compounds, and to a process for making such compounds. In still another embodiment, the present invention relates to polyisobutylene compounds that can be used to synthesize polyurethanes and polyureas, to polyurethane and polyurea compounds made via the use of such polyisobutylene compounds, and to processes for making such compounds. In yet another embodiment, the present invention relates to polyisobutylene compounds containing urea or urethane segments therein, and to a method of producing such compounds. In still yet another embodiment, the present invention relates to a polymer having one or more different soft segments and one or more different hard segments. | 02-14-2013 |
20130281742 | METHOD AND SYNTHESIS OF INITIATORS FOR TELECHELIC POLYISOBUTYLENES - A new methodology for the synthesis of a novel difunctional- and a known trifunctional initiator, i.e., 1,3-di(2-methoxy-2-propyl)-5-isopropyl benzene and 1,3,5-tri(2-methoxy-2-propyl)benzene, respectively, for the preparation of di- and tri-telechelic polyisobutylenes. The synthesis proceeds in three steps: 1) catalytic peroxidation of 1,3,5-triisopropylbenzene, 2) reduction of the peroxides to the corresponding alcohols, and 3) methylation of the alcohols. By controlling the conversion of the key peroxidation step the relative ratio of di- and tri-functional intermediates can be controlled. By the use of the 1,3-di(2-methoxy-2-propyl)-5-isopropyl-benzene, well-defined di-methoxy telechelic polyisobutylenes can be synthesized. Although the overall combined yield of the two initiators was only 14-20%, because of the low cost of the starting material, reagents used, and simple manipulations these compounds represent the most cost effective initiators to-date for the preparation of telechelic polyisobutylenes. | 10-24-2013 |
20130331538 | MELT PROCESSIBLE POLYUREAS AND POLYUREA-URETHANES, METHOD FOR THE PRODUCTION THEREOF AND PRODUCTS MADE THEREFROM - A polyurea or polyurea-urethane elastomer comprises a soft polymer segment and a hard polymer segment, wherein the hard polymer segment includes polyurea groups in combination with H-bond accepting chain extenders (HACEs) to reduce the flow temperature (T | 12-12-2013 |
20140073743 | POLY(OCTYLCYANOACRYLATE)-POLYISOBUTYLENE POLYMER CONETWORK, METHOD FOR THE PRODUCTION THEREOF AND USES THEREOF - A polymer conetwork formed from the polymerization reaction of octyl-cyanoacrylate and a tri-telechelic star polymer comprising polyisobutylene terminated with cyanoacrylate groups (Ø(PIB-CA) | 03-13-2014 |
Patent application number | Description | Published |
20100287555 | USING COMPOSITE SYSTEMS TO IMPROVE FUNCTIONALITY - Systems and methods are provided for enabling communication between a composite system providing additional functionality not contained in existing legacy systems and other existing systems using different commands, variables, protocols, methods, or instructions, when data may be located on more than one system. In an embodiment, multiple software layers are used to independently manage different aspects of an application. A business logic layer may be used in an embodiment to facilitate reading/writing operations on data that may be stored locally and/or on external systems using different commands, variables, protocols, methods, or instructions. A backend abstraction layer may be used in an embodiment in conjunction with the business logic layer to facilitate communication with the external systems. A user interface layer may be used in an embodiment to manage a user interface, a portal layer to manage a user context, and a process logic layer to manage a workflow. | 11-11-2010 |
20110125667 | Process Pattern Automation in Tools for Business Process Modeling - A modified design utility for business process provides patterns. Patterns are a more efficient manner in which a technical or non-technical user of the design utility can define a business process to create a business application. Patterns are groupings of business elements that are commonly utilized in many business processes. Selection of a pattern in the design utility can generate suggestions for additional patterns or business elements to complete the overall business process based on known commonalities where the suggestions are constrained based on the types of undefined business element associations for the pattern. | 05-26-2011 |
Patent application number | Description | Published |
20080262345 | Image registration of multiple medical imaging modalities using a multiple degree-of-freedom-encoded fiducial device - Disclosed is a system and method for registering images from two medical imaging modalities in a six-degree-of-freedom coordinate space, for the purpose of providing real time registered imagery for optimization of medical procedures. The system and method uses fiducial that is visible to the first imager and in a fixed position and orientation relative to the second imager. The first imager may be an X-ray device such as a C-arm fluoroscope, and the second imager may be a Transrectal Ultrasound (TRUS) device. | 10-23-2008 |
20080306384 | Apparatus and method for computing 3D ultrasound elasticity images - Disclosed is a system and method for computing ultrasound 3D elasticity images. The method includes acquiring ultrasound RF data in a rest state, in which substantially no pressure is applied to a tissue medium, and acquiring ultrasound data in a stressed state, in which pressure is applied to a tissue medium having an aberration, and computing a measured displacement image from the two RF data sets. The method also includes computing an initial estimated displacement image, which is derived from a 3D elasticity model. The method further includes computing an optimization loop, wherein the initial estimated displacement image is adjusted to converge on the measured displacement image. The optimized estimated displacement image is then segmented and superimposed over the rest state ultrasound image. Further, the original 3D elasticity model is adjusted to match the optimized estimated displacement image. | 12-11-2008 |
20100056900 | APPARATUS FOR INSERTION OF A MEDICAL DEVICE WITHIN A BODY DURING A MEDICAL IMAGING PROCESS AND DEVICES AND METHODS RELATED THERETO - A device, system, and method for entering a medical device such as a needle into the body inside a medical imager such as a MRI scanner, CT, X-ray fluoroscopy, and ultrasound imaging, from within a body cavity (such as the rectum, vagina, or laparoscopically accessed cavity). A three degree-of-freedom mechanical device translates and rotates inside the cavity and enters a needle into the body, and steers the needle to a target point selected by the user. The device is guided by real-time images from the medical imager. Networked computers process the medical images and enable the clinician to control the motion of the mechanical device that is operated within the imager, outside of the imager or remotely from outside the imager. | 03-04-2010 |
20100198068 | ROBUST AND ACCURATE FREEHAND 3D ULTRASOUND - Disclosed is a system and method for computing out of plane motion between two ultrasound images. The method identifies regions of fully developed speckle that are common to the two images, computes a correlation coefficient corresponding to the two fully developed speckle image regions, and then computing an elevation distance corresponding to the correlation coefficient. The method exploits the measurable and characterizable relation between inter-image correlation and elevation distance, which may be determined from fully developed speckle regions. The method also identifies regions within the ultrasound images related to structure (e.g., vein or bone), and disregards these regions. | 08-05-2010 |
20100239144 | Marker Localization Using Intensity-Based Registration of Imaging Modalities - Provided are methods and systems for registering image data from two imaging modalities, to produce an image having features from both imaging technologies. In particular, the methods and systems relate to intensity-based registration of the image data. The imaging modalities may be, for example, ultrasound and x-ray, magnetic resonance imaging, or a pre-operative plan. | 09-23-2010 |
20110311030 | C-Arm Rotation Encoding Methods and Apparatus - This invention provides a method for estimating C-ARM fluoroscope rotation pose, and related programmed media and kits. In one embodiment the method includes measuring an angle of the C-arm using an accelerometer affixed to the C-arm, wherein the accelerometer is not moving during the measurement. The method includes generating angle correction equations based on differences between C-arm poses and corresponding accelerometer angles, and optionally generating structural compensation equations to compensate for structural flexion or deformation of the C-arm. | 12-22-2011 |
20110313285 | C-ARM POSE ESTIMATION USING INTENSITY-BASED REGISTRATION OF IMAGING MODALITIES - This invention provides a method for estimating C-arm fluoroscope pose. The method involves introducing a coordinate system into a C-arm image, and applying intensity-based 2D/3D registration without segmentation to the coordinate system C-arm image and an image or known model of the coordinate system, wherein the intensity-based 2D/3D registration yields the C-arm pose. The coordinate system may be provided by introducing one or more markers or a fiducial into an image. | 12-22-2011 |
20140039298 | APPARATUS FOR INSERTION OF A MEDICAL DEVICE WITHIN A BODY DURING A MEDICAL IMAGING PROCESS AND DEVICES AND METHODS RELATED THERETO - A device, system, and method for entering a medical device such as a needle into the body inside a medical imager such as a MRI scanner, CT, X-ray fluoroscopy, and ultrasound imaging, from within a body cavity (such as the rectum, vagina, or laparoscopically accessed cavity). A three degree-of-freedom mechanical device translates and rotates inside the cavity and enters a needle into the body, and steers the needle to a target point selected by the user. The device is guided by real-time images from the medical imager. Networked computers process the medical images and enable the clinician to control the motion of the mechanical device that is operated within the imager, outside of the imager or remotely from outside the imager. | 02-06-2014 |
20140121501 | AUTOMATED INTRAOPERATIVE ULTRASOUND CALIBRATION - An ultrasound calibration phantom comprises a portion including at least one fiducial structure having a selected geometric arrangement; a portion adapted for mechanical coupling of the ultrasound calibration phantom to a transrectal ultrasound (TRUS) stepper; and a guide for at least one surgical instrument, the guide being mechanically coupled to the fiducial structure and/or to the TRUS stepper at a selected pose relative to the fiducial structure. A calibration method uses the calibration phantom and provides automatic, intraoperative calibration of ultrasound imaging systems. The invention is useful in ultrasound-guided clinical procedures. | 05-01-2014 |
20140187913 | APPARATUS FOR INSERTION OF A MEDICAL DEVICE DURING A MEDICAL IMAGING PROCESS - The end-effector includes a sheath and a medical device or needle carrier that is disposed within the interior compartment of the sheath. An aperture is located in a portion of the sheath proximal a distal end of the sheath that is inserted into a natural or artificial cavity. This device is guided by a real-time imager. | 07-03-2014 |
20140276001 | Device and Method for Image-Guided Surgery - In one aspect the invention provides a reference device that enhances image-guided surgical interventions. The reference device is tracked by the imaging system and used to verify the accuracy of the intervention tool placement before and during the intervention. The reference device holds a reference sensor in a position aligned with patient anatomy, so that images are displayed in the correct orientation to the operator, aiding in target recognition and better navigation. Also provided are methods using the reference device and programmed computer media for implementing at least a part of the methods. | 09-18-2014 |
Patent application number | Description | Published |
20080269604 | Ultrasound Calibration and Real-Time Quality Assurance Based on Closed Form Formulation - Disclosed is a system and method for intra-operatively spatially calibrating an ultrasound probe. The method includes determining the relative changes in ultrasound images of a phantom, or high-contrast feature points within a target volume, for three different ultrasound positions. Spatially calibrating the ultrasound probe includes measuring the change in position and orientation of the probe and computing a calibration matrix based on the measured changes in probe position and orientation and the estimated changes in position and orientation of the phantom. | 10-30-2008 |
20110237947 | ROBOTIC 5-DIMENSIONAL ULTRASOUND - A robotic 5D ultrasound system and method, for use in a computer integrated surgical system, wherein 3D ultrasonic image data is integrated over time with strain (i.e., elasticity) image data. By integrating the ultrasound image data and the strain image data, the present invention is capable of accurately identifying a target tissue in surrounding tissue; segmenting, monitoring and tracking the target tissue during the surgical procedure; and facilitating proper planning and execution of the surgical procedure, even where the surgical environment is noisy and the target tissue is isoechoic. | 09-29-2011 |
20120310112 | APPARATUS FOR INSERTION OF A MEDICAL DEVICE DURING A MEDICAL IMAGING PROCESS - The end-effector ( | 12-06-2012 |
20150216621 | IMAGE REGISTRATION OF MULTIPLE MEDICAL IMAGING MODALITIES USING A MULTIPLE DEGREE-OF-FREEDOM-ENCODED FIDUCIAL DEVICE - Disclosed is a system and method for registering images from two medical imaging modalities in a six-degree-of-freedom coordinate space, for the purpose of providing real time registered imagery for optimization of medical procedures. The system and method uses fiducial that is visible to the first imager and in a fixed position and orientation relative to the second imager. The first imager may be an X-ray device such as a C-arm fluoroscope, and the second imager may be a Transrectal Ultrasound (TRUS) device. | 08-06-2015 |
Patent application number | Description | Published |
20100041134 | SELF-ASSEMBLING MULTICELLULAR BODIES AND METHODS OF PRODUCING A THREE-DIMENSIONAL BIOLOGICAL STRUCTURE USING THE SAME - Structures and methods for tissue engineering include a multicellular body including a plurality of living cells. A plurality of multicellular bodies can be arranged in a pattern and allowed to fuse to form an engineered tissue. The arrangement can include filler bodies including a biocompatible material that resists migration and ingrowth of cells from the multicellular bodies and that is resistant to adherence of cells to it. Three-dimensional constructs can be assembled by printing or otherwise stacking the multicellular bodies and filler bodies such that there is direct contact between adjoining multicellular bodies, suitably along a contact area that has a substantial length. The direct contact between the multicellular bodies promotes efficient and reliable fusion. The increased contact area between adjoining multicellular bodies also promotes efficient and reliable fusion. Methods of producing multicellular bodies having characteristics that facilitate assembly of the three-dimensional constructs are also provided. | 02-18-2010 |
20110313542 | ENGINEERED BIOLOGICAL NERVE GRAFT, FABRICATION AND APPLICATION THEREOF - An engineered three-dimensional structure includes living cells cohered with each other. The living cells suitably include Schwann cells and at least one other type of cell. The cells accompanying the Schwann cells can suitably be bone marrow stem cells or another type of cell having one or more anti-inflammatory properties. The structure is suitably a graft that facilitates restorative axon growth when the graft is implanted between the proximal and distal stubs of a severed nerve in a living organism. The graft can optionally include a plurality of acellular conduits extending between opposite axial ends of the graft. Bio-printing techniques can be used to assemble a three-dimensional construct that becomes through maturation an axon-guiding graft, by stacking a plurality of multicellular bodies, each of which includes a plurality of living cells cohered to one another to sufficiently to avoid collapsing when the multicellular bodies are stacked to form the structure. | 12-22-2011 |
20120196343 | SELF-ASSEMBLING MULTICELLULAR BODIES AND METHODS OF PRODUCING A THREE-DIMENSIONAL BIOLOGICAL STRUCTURE USING THE SAME - Structures and methods for tissue engineering include a multicellular body including a plurality of living cells. A plurality of multicellular bodies can be arranged in a pattern and allowed to fuse to form an engineered tissue. The arrangement can include filler bodies including a biocompatible material that resists migration and ingrowth of cells from the multicellular bodies and that is resistant to adherence of cells to it. Three-dimensional constructs can be assembled by printing or otherwise stacking the multicellular bodies and filler bodies such that there is direct contact between adjoining multicellular bodies, suitably along a contact area that has a substantial length. The direct contact between the multicellular bodies promotes efficient and reliable fusion. The increased contact area between adjoining multicellular bodies also promotes efficient and reliable fusion. Methods of producing multicellular bodies having characteristics that facilitate assembly of the three-dimensional constructs are also provided. | 08-02-2012 |
20130029008 | ENGINEERED COMESTIBLE MEAT - Provided are engineered meat products formed as a plurality of at least partially fused layers, wherein each layer comprises at least partially fused multicellular bodies comprising non-human myocytes and wherein the engineered meat is comestible. Also provided are multicellular bodies comprising a plurality of non-human myocytes that are adhered and/or cohered to one another; wherein the multicellular bodies are arranged adjacently on a nutrient-permeable support substrate and maintained in culture to allow the multicellular bodies to at least partially fuse to form a substantially planar layer for use in formation of engineered meat. Further described herein are methods of forming engineered meat utilizing said layers. | 01-31-2013 |
20130255003 | ENGINEERED LEATHER AND METHODS OF MANUFACTURE THEREOF - Engineered animal skin, hide, and leather comprising a plurality of layers of collagen formed by cultured animal collagen-producing (e.g., skin) cells. Layers may be formed by elongate multicellular bodies comprising a plurality of cultured animal cells that are adhered and/or cohered to one another; wherein the elongate multicellular bodies are arranged to form a substantially planar layer for use in formation of engineered animal skin, hide, and leather. Further described herein are methods of forming engineered animal skin, hide, and leather utilizing said layers of animal collagen-producing cells. | 10-03-2013 |
20140093618 | ENGINEERED COMESTIBLE MEAT - Provided are engineered meat products formed as a plurality of at least partially fused layers, wherein each layer comprises at least partially fused multicellular bodies comprising non-human myocytes and wherein the engineered meat is comestible. Also provided are multicellular bodies comprising a plurality of non-human myocytes that are adhered and/or cohered to one another; wherein the multicellular bodies are arranged adjacently on a nutrient-permeable support substrate and maintained in culture to allow the multicellular bodies to at least partially fuse to form a substantially planar layer for use in formation of engineered meat. Further described herein are methods of forming engineered meat utilizing said layers. | 04-03-2014 |
20140220685 | SELF-ASSEMBLING MULTICELLULAR BODIES AND METHODS OF PRODUCING A THREE-DIMENSIONAL BIOLOGICAL STRUCTURE USING THE SAME - Structures and methods for tissue engineering include a multicellular body including a plurality of living cells. A plurality of multicellular bodies can be arranged in a pattern and allowed to fuse to form an engineered tissue. The arrangement can include filler bodies including a biocompatible material that resists migration and ingrowth of cells from the multicellular bodies and that is resistant to adherence of cells to it. Three-dimensional constructs can be assembled by printing or otherwise stacking the multicellular bodies and filler bodies such that there is direct contact between adjoining multicellular bodies, suitably along a contact area that has a substantial length. The direct contact between the multicellular bodies promotes efficient and reliable fusion. The increased contact area between adjoining multicellular bodies also promotes efficient and reliable fusion. Methods of producing multicellular bodies having characteristics that facilitate assembly of the three-dimensional constructs are also provided. | 08-07-2014 |
20150079238 | EDIBLE AND ANIMAL-PRODUCT-FREE MICROCARRIERS FOR ENGINEERED MEAT - Edible microcarriers, including microcarrier beads, microspheres and microsponges, appropriate for use in a bioreactor to culture cells that may be used to form a comestible engineered meat product. For example, the edible microcarriers described herein may include porous microcarriers that may be used to grow cells (e.g., smooth muscle cells) and may be included with the cells in the final engineered meat product, without requiring modification or removal of the cells from the microcarriers. In a particular example, the edible microcarriers may be formed of cross-linked pectin, such as pectin-thiopropionylamide (PTP), and RGD-containing polypeptide, such as thiolated cardosin A. Methods of forming edible microcarriers, methods of using the edible microcarriers to make engineered meat, and engineered meat including the edible microcarriers are also described herein. | 03-19-2015 |
Patent application number | Description | Published |
20090202047 | Implicit emergency registration set - A method for providing an implicit emergency registration set is disclosed. The method can include initiating an identifier selection procedure. The method can also include identifying whether a user has a dedicated emergency telephone uniform resource identifier (tel URI), and, if so, selecting it. The method can further include identifying, when the user does not have a dedicated emergency tel URI, whether the user's internet protocol (IP) multimedia private identity (IMPI) is known. The method can additionally include identifying, when the user's IMPI is known, whether the user's IMPI has a non-shared tel URI, and, if so, selecting it, but otherwise selecting a tel URI of the user's IMPI. The method can also include identifying, when the user's IMPI is not known, whether a shared tel URI is available, and selecting it if it is, otherwise selecting a tel URI from a non-shared set. | 08-13-2009 |
20110182285 | Sessions In A Communication System - A method in a communications system for handling responses to messages includes a step of sending a message from a first party to a second party. A response to the message is sent, with the response including at least one parameter in breach of a policy for a communication between the first party and the second party. A network controller detects that the response includes at least one parameter breaching the policy. The at least one parameter is modified to be consistent with the policy. | 07-28-2011 |
Patent application number | Description | Published |
20110258607 | METHOD FOR AUTOMATED ERROR DETECTION AND VERIFICATION OF SOFTWARE - A method for automated error detection and verification of software comprises providing a model of the software, the model including one or more model inputs and one or more model outputs, and a plurality of blocks embedded within the model each with an associated block type, the block types each having a plurality of associated block-level requirements. The method further comprises topologically propagating from the model inputs, a range of signal values or variable values, and error bounds, across computational semantics of all the blocks to the model outputs. Each behavior pivot value for a given block is identified and examined to determine if modifying or extending the propagated range by the error bound will or may cause a signal value to fall on either side of the behavioral pivot value. All occurrences of the signal value that will or may fall on either side of the behavioral pivot value are reported. | 10-20-2011 |
20120210173 | ERROR PROPAGATION IN A SYSTEM MODEL - Embodiments of the present subject matter can enable the analysis of signal value errors for system models. In an example, signal value errors can be propagated through the functional blocks of a system model to analyze possible effects as the signal value errors impact incident functional blocks. This propagation of the errors can be applicable to many models of computation including avionics models, synchronous data flow, and Kahn process networks. | 08-16-2012 |
20130019224 | SYSTEMS AND METHODS FOR VERIFYING MODEL EQUIVALENCEAANM Madl; GaborAACI St. Louis ParkAAST MNAACO USAAGP Madl; Gabor St. Louis Park MN USAANM Oglesby; David V.AACI Brooklyn CenterAAST MNAACO USAAGP Oglesby; David V. Brooklyn Center MN USAANM Chakraborty; KuntalAACI SingurAACO INAAGP Chakraborty; Kuntal Singur INAANM Bhatt; DeveshAACI Maple GroveAAST MNAACO USAAGP Bhatt; Devesh Maple Grove MN USAANM Hickman; Stephen OtisAACI MaricopaAAST AZAACO USAAGP Hickman; Stephen Otis Maricopa AZ US - Systems and methods for verifying model equivalence are provided. In one implementation, a system includes: a memory device that stores a reference model (RM) and comparison model (CM), wherein the CM and the RM are constrained by a set of rules; and a processing unit that generates a reference model representation (RMR) from the RM and stores the RMR on the memory device; the processing unit further generates a comparison model representation (CMR) from the comparison model (CM) and stores the CMR on the memory device, wherein the processing unit further to: verifies that the CMR compatibly implements the RMR; verifies that a CM data flow diagram derived from the CMR compatibly implements a RM data flow diagram derived from the RMR; and verifies that every CM semantic unit implements a behavior that corresponds to a RM semantic unit and every RM semantic unit is accounted for in the CM. | 01-17-2013 |
20140019943 | SYSTEMS AND METHODS FOR VERIFYING EXPRESSION FOLDING - A system for verifying that a comparison model having folded expressions matches a reference model includes at least one memory device that stores a reference model and a comparison model, wherein the comparison model was previously generated based on the reference model. The reference model adheres to a first set of syntax and semantics, wherein the reference model includes a plurality of first expressions, each of the first expressions including a first operator and a first operand. The comparison model adheres to a second set of syntax and semantics, wherein the comparison model includes a second expression, the second expression including a second operator and a second operand. The system further includes a processing unit configured to match the second expression with the plurality of first expressions. | 01-16-2014 |
Patent application number | Description | Published |
20080249165 | Glycosides and Salts Thereof - The invention relates to new polysulfated glycosides of formula (I), the salts thereof formed with alkali metals or alkaline-earth metals, as well as the pharmaceutical compositions containing these compounds as active ingredients. Furthermore the invention provides a method of preventing, treating or alleviating the symptoms of acute and chronic inflammatory disorders of the airways of mammals—including asthma and asthma-related pathologies. | 10-09-2008 |
20090215717 | Sulfated oligosaccharides - The invention relates to sulfated oligosaccharides, more particularly to new pharmaceutical uses of sulfated oligosaccharides. The invention provides a method of preventing, treating or alleviating the symptoms of acute and chronic’, inflammatory disorders of the airways of mammals—including asthma and asthma-related pathologies. The invention further provides use of a sulfated oligosaccharide in the preparation of a medicament for the treatment of acute and chronic inflammatory disorders of the airways of mammals. The invention yet further provides use of a sulfated oligosaccharide to preventing, treating or alleviating the symptoms of acute and chronic inflammatory disorders of the airways of mammals—including asthma and asthma-related pathologies. | 08-27-2009 |
20130303572 | NOVEL INHIBITORS OF MATRIX METALLOPROTEINASES - Compounds of general formula (I), salts or solvates thereof and pharmaceutical compositions containing same: | 11-14-2013 |
Patent application number | Description | Published |
20110031879 | STREET LIGHTING LAMP WITH LONG LIFE, HIGH EFFICIENCY, AND HIGH LUMEN MAINTENANCE - A lamp includes a discharge vessel and electrodes extending into the discharge vessel. The lamp further includes an ionizable fill sealed within the vessel. The fill includes an inert gas and a halide component. The halide component includes a sodium halide, a thallium halide, at least one of a calcium halide and a strontium halide, and at least one of a rare earth halide. The rare earth halide is selected from the group consisting of lanthanum, cerium, praseodymium, samarium and neodymium, and combinations thereof. | 02-10-2011 |
20110031880 | STREET LIGHTING LAMP WITH LONG LIFE, HIGH EFFICIENCY, AND HIGH LUMEN MAINTENANCE - A lamp includes a discharge vessel and electrodes extending into the discharge vessel. The lamp further includes an ionizable fill sealed within the vessel. The fill includes an inert gas and a halide component. The halide component includes a sodium halide, a thallium halide, at least one of a calcium halide and a strontium halide, and at least one of a rare earth halide. The rare earth (RE) halide is selected from the group consisting of lanthanum, cerium, praseodymium, samarium and neodymium, and combinations thereof. The fill establishes a Na/RE ratio of 8≦Na/RE≦48. | 02-10-2011 |
Patent application number | Description | Published |
20080239535 | CERTIFYING WHILE SERVOWRITING MEDIA - Certifying a media while servowriting the media by formatting a full compliment of servo data in storage tracks of the media in a minimum number of passes per storage track while simultaneously performing a 100% media certification of the storage tracks during the minimum number of passes per storage track. | 10-02-2008 |
20080239540 | MEDIA SERVOWRITER/CERTIFIER - Certifying a storage media while servowriting the media by formatting a full compliment of servo data in storage tracks of the media in a minimum number of passes per storage track while simultaneously performing a 100% media certification of the storage tracks during the minimum number of passes per storage track. | 10-02-2008 |
20100302663 | METHOD OF MEASURING NON-COHERENT RUNOUT FOR A DISK DRIVE - In a disk drive, a modified adaptive runout compensation algorithm is employed to measure non-coherent repeatable runout (RRO) of a track. The adaptive runout compensation algorithm is used to control the transducer head to follow the average RRO of adjacent tracks during the process of computing correction factors for non-coherent RRO for a given track. The adaptive runout compensation algorithm does not completely adapt to both the coherent and non-coherent RRO of a particular track because the transducer head is positioned over any one particular track for only a limited number of revolutions. | 12-02-2010 |
20110216438 | READER-WRITER OFFSET CORRECTION FOR A DISK DRIVE - A servo wedge on a recording medium for a disk drive includes a gray-code field that stores a micro-jog correction factor for a data track. The micro-jog correction factor compensates for the effect of accumulated track pitch variations. In one embodiment, the radial wedge formed by gray-code fields for adjacent data tracks is a continuous radial wedge similar to the gray-code field used for encoding track numbers. | 09-08-2011 |
20120019957 | METHOD OF MEASURING NON-COHERENT RUNOUT FOR A DISK DRIVE - In a disk drive, a modified adaptive runout compensation algorithm is employed to measure non-coherent repeatable runout (RRO) of a track. The adaptive runout compensation algorithm is used to control the transducer head to follow the average RRO of adjacent tracks during the process of computing correction factors for non-coherent RRO for a given track. The adaptive runout compensation algorithm does not completely adapt to both the coherent and non-coherent RRO of a particular track because the transducer head is positioned over any one particular track for only a limited number of revolutions. | 01-26-2012 |
20120033317 | POSITION ERROR SIGNAL DEMODULATION WITH TARGET-BASED BLENDING - In a disk drive, a method for servo burst-decoding demodulation that accommodates track pitch variation. Depending on the distance a read head is displaced from a read head target position, a target-based blending scheme, a position-based blending scheme, or a weighted combination of both is used to determine the position of the transducer head. When the transducer head is relatively close to the target position, the target-based blending scheme is used to decode servo bursts and calculate the exact head position. When the transducer head is relatively far from the target position, the position-based blending scheme is used to decode servo bursts and calculate head position. When the transducer head is an intermediate distance from the target position, a weighted combination of the target-based and position-based blending schemes is used. | 02-09-2012 |
20130114159 | METHOD OF WRITING A PREAMBLE FIELD ON A DISK DRIVE TO REDUCE TRACK SQUEEZE - Preamble fields are written on a storage disk in a hard disk drive in a way that reduces track squeeze. Preamble fields for a particular data storage track on the storage disk are written over multiple revolutions of the storage disk to eliminate low-frequency variations of the preamble stitch line from an ideal position of the preamble stitch line. By writing the preamble fields for one data storage track over multiple revolutions, and by writing the preamble fields in each revolution to non-consecutive servo wedges, low-frequency variations of the preamble stitch line from its ideal position can be converted to high-frequency variations of the preamble stitch line that do not produce low-frequency track squeeze | 05-09-2013 |
Patent application number | Description | Published |
20100261681 | ALPHA-CHLORO AND ALPHA-BROMO PHOSPHONATE ANALOGS OF LYSOPHOSPHATIDIC ACID AND METHODS OF MAKING AND USING THEREOF - Described herein is the synthesis and pharmacology of a series of α-substituted methylene phosphonate analogs, in which the α-CH | 10-14-2010 |
20120135967 | LPA RECEPTOR AGONISTS AND ANTAGONISTS AND METHODS OF USE - Disclosed are compounds according to formula (I) as well as pharmaceutical compositions which include those compounds. Also disclosed are methods of using such compounds, which have activity as agonists or as antagonists of LPA receptors; such methods including inhibiting LPA activity on an LPA receptor, modulating LPA receptor activity, treating cancer, enhancing cell proliferation, treating a wound, treating apoptosis or preserving or restoring function in a cell, tissue, or organ, culturing cells, preserving organ or tissue function, and treating a dermatological condition. | 05-31-2012 |
20120190650 | Inhibitors of Autotaxin - Stabilized benzyl phosphonic acid and naphthyl phosphonic acid analog compounds are effective in inhibiting the activity of autotaxin. | 07-26-2012 |
20140057936 | LPA2 Receptor-Specific Benzoic Acid Derivatives - Disclosed are compounds effective for inhibiting cellular apoptosis and for protecting cells and tissues from the apoptotic effects of chemotherapeutic agents and/or ionizing radiation. Compounds of the invention act as agonists of the LPA | 02-27-2014 |
20140206714 | LPA2 RECEPTOR-SPECIFIC BENZOIC ACID DERIVATIVES - Disclosed are compounds effective for inhibiting cellular apoptosis and for protecting cells and tissues from the apoptotic effects of chemotherapeutic agents and/or ionizing radiation. Compounds of the invention act as agonists of the LPA | 07-24-2014 |
Patent application number | Description | Published |
20080271923 | Flow hydraulic amplification for a pulsing, fracturing, and drilling (PFD) device - Disclosed is a device and method and/or system for generating pulses to improve drilling rates, the ability to drill straighter and farther or fracturing or injection efficiencies in a geological formation that may contain desirable hydrocarbons. This system may also be used in other types of drilling or fracturing operations, whether to unclog arteries or to open formations for underground storage in conjunction with pulsing/fracturing. Alternately, this system could be used to create large pulses downhole for seismic purposes in that they are of such magnitude that they could be readily received in nearby wells or several of uphole locations. The system and method comprises several pulse generating devices longitudinally and axially positioned within an annular drill collar flow channel or PIM such that the PFD medium flows through the annular drill collar flow channel and the PFD medium is guided into one or more sets of selectively reversible flow, upper and lower flow connecting channels, wherein the connecting channels are connected to an inner flow channel and the annular drill collar flow channel, and wherein the annular drill collar flow channel is acted upon by one or more flow throttling devices. In one of the devices listed, the device utilizes one or more turbines residing near and within proximity of a flow diverter that diverts drilling mud into and away from turbine blades such that the force of the PFD medium causes the turbine blades and the turbine to rotationally spin around a coil assembly for power. | 11-06-2008 |
20090107723 | Pulse rate of penetration enhancement device and method - Disclosed is a system and device relating to flow pulsing for use in down-hole drilling rate of penetration (ROP) enhancement and measurement while drilling (MWD) using a pulse drilling device (PDD) with a fast acting valve in conjunction with a pilot valve to produce high pressure, high amplitude, low duration pressure pulses. | 04-30-2009 |
20090114396 | Wellsite measurement and control while producing device - Disclosed is a device, method and system for a measurement while producing (MWP) and flow throttling (FTD) device for placement in a pipe with liquid or gas flowing through it such as an oil or gas well's wellhead, casing, tubing, or horizontal or lateral passage which is responsive to the flow of fluid through it. The MWP/FTD device can create pressure pulses through the production fluid or otherwise send signals to provide bit data that are read and analyzed at the wellhead or externally thru wireless communications. The data analysis provides information regarding pressure, fluid flow, and type of fluid/gas flowing primarily within the lateral passages or generally anywhere the MWP/FTD is situated. The device helps identify whether the pipe, lateral or other passage should remain open, closed or restricted. This identification occurs by use of either autonomous control and sensors within the device and/or pre-programmed or wirelessly controlled signals that are transmitted from the well head (or externally) to the MWP/FTD. The MWP/FTD is subsequently urged to regulate the fluid/gas flow. | 05-07-2009 |
20100147525 | High pressure fast response sealing system for flow modulating devices - Disclosed is an apparatus, method and system comprising one or more devices capable of modulating fluid flow, the fluid being a liquid or a gas resulting in a pressure fluctuation in a fluid flowing within a flow channel, comprising: a flow modulating device that acts as a servo valve such that the device comprises a shaft and a moveable actuator that slides along the shaft, wherein the shaft and the actuator are positioned at any angle within a principal fluid flow channel such that the fluid flows through the principal fluid flow channel. The fluid flowing within the principal fluid flow channel is selectively reversible and the fluid is connected to both an inner pilot flow channel and the principal fluid flow channel wherein the flow modulating device includes a particulate barrier system having at least one seal system comprising an upper outer seal and a lower outer seal prohibiting fluid particulates from entering the inner pilot flow channel and also includes an upper inner seal and a lower inner seal that further prohibit residual particulates from reaching any mating surface between the shaft of the flow modulating device and the upper seal, the upper inner seal, the lower outer seal, and the lower inner seal. The particulate barrier system operates in a fluid flow field wherein the fluid can flow in any direction and utilizes a sealing system wherein an upper outer seal and a lower outer seal prohibit particulates from reaching the respective surfaces of an upper inner seal and lower inner seal of the flow modulating device. An upper inner seal and lower inner seal further prohibit residual particulates from reaching surfaces between the seal and that of the shaft of the flow modulating device. | 06-17-2010 |
20120327742 | Borehole Flow Modulator and Inverted Seismic Source Generating System - The present invention relates to the vertical seismic profiling (VSP) of geological formations in which profiling is used to obtain information for performing precise interpretations of geophysical seismic data and better understanding of geophysical information. The disclosure involves using a sound source for generating primary and secondary seismic pulses within well boreholes. The seismic profiling system obtains information regarding a geological formation traversed by a borehole with controllable downhole seismic pulse generators with drill string tool(s). The tool(s) have contact with and are coupled to the formation. A seismic pulsing device (SPD) is attached to a portion of the drill string and a valve controller is used to control opening and closing the valve causing high amplitude short duration ultra wide band pressure pulses, generating primary seismic waves sent into surrounding geological formations. This generates secondary seismic waves received that can be detected by geophones or similar devices. | 12-27-2012 |
20130048379 | Controlled Full Flow Pressure Pulser for Measurement While Drilling (MWD) Device - An apparatus, method, and system described for generating pressure pulses in drilling fluid utilizing a flow throttling device which includes a controllable pulser operating sequentially within a downhole assembly within a drill string of a drill pipe. The system includes drilling fluid, fluid flow, and fluid drilling pump which when combined creates fluid flow into a bore pipe annulus within the downhole assembly creating a base line bore pipe pressure wherein bore pipe pressure is sensed via a sensor and information is sent to a Digital Signal Processor (DSP) that interprets the information. The DSP also receives information from an annulus pressure sensor that senses drilling fluid pressure as it returns to the pump. The DSP recognizes pressure variation input from the annulus pressure sensor and bore pipe pressure sensor and detects pressure variation providing signals as data information to the DSP, determining required action to adjust pulser operation. | 02-28-2013 |
20130051177 | Full Flow Pulser for Measurement While Drilling (MWD) Device - An apparatus, method, and system described for generating pressure pulses in a drilling fluid utilizing a flow throttling device longitudinally and axially positioned within the center of a main valve actuator assembly is described. The main valve actuator assembly includes a main valve pressure chamber, a magnetic cup encompassing a rotary magnetic coupling, and a pilot actuator assembly. Passage of drilling fluid through a series of orifices, valves, shields, and screens where the fluid eventually combines with a pilot exit fluid that flows toward a main exit flow such that as the fluid becomes a pilot fluid that ultimately combines with the main flow such that the combined fluid causes one or more flow throttling devices to generate large, rapid controllable pulses that produce transmission of well developed signals easily distinguished from other noise resulting from other vibrations due to nearby equipment that is within or exterior to the borehole such that the signals also provide predetermined height, width and shape. | 02-28-2013 |
20140090734 | Hydroelectric Control Valve for Remote Locations - The present disclosure describes a hydroelectric control valve (HCV) for a fluid pipeline including an inlet and outlet (or input and output) section attached to the same pipeline wherein fluid flows into and out of the HCV comprising a bell reservoir section and a seat reservoir section which are both capped, where the bell reservoir section and the seat reservoir section are aligned with each other and are also perpendicular to fluid flowing through the pipeline. A channel which can be electrically activated and thus controlled is attached to the bell section, such that the bell reservoir section includes a bell relief channel in fluid communication with an outlet section and also a separate hydraulic poppet channel in communication with a locating needle head. In addition, turbine and deactivation channels are employed such that the deactivation channel connects the input section and the seat reservoir. | 04-03-2014 |
20150300153 | Controlled Pressure Pulser for Coiled Tubing Measurement While Drilling Applications - An apparatus and system for generating pressure pulses for enhancing and completing a well bore within a coiled tubing assembly including: a CT-MWD-FTD tool longitudinally and axially positioned within the center of a main valve assembly including a main valve. The drilling fluid is subsequently split into both an inlet main fluid stream and a pilot fluid stream, wherein the pilot fluid stream subsequently flows such that the pilot fluid recombines with the main flow stream to become a main exit fluid flow. The main exit fluid flow then proceeds toward a motor housing wherein one or more annular pressure sensors measure the pressure of fluid flow with sensors that send signals to a Digital Signal Processor (DSP) that controls flow throttling devices which generate controllable, large, rapid and measurable energy pulses. | 10-22-2015 |
Patent application number | Description | Published |
20090233913 | OPTICAL ISOMERS OF DIHYDRO-2,3-BENZODIAZEPINES AND THEIR STEREOSELECTIVE SYNTHESIS - The present invention relates to dihydro-2,3-benzodiazepine compounds of high enantiomeric purity according to the general formula (I), which contain an asymmetric centre at the position 4 of the dihydro-2,3-benzodiazepine compound, and the preparation thereof and the used intermediates as well. These compounds have anti-convulsiveA muscle relaxant and neuroprotective effect due their non-competitive AMPA antagonistic properties. | 09-17-2009 |
20090281137 | INDOL-2-ONE DERIVATIVES FOR THE TREATMENT OF CENTRAL NERVOUS DISORDERS, GASTROINTESTINAL DISORDERS AND CARDIOVASCULAR DISORDERS - The present invention is related to new 3,3-disubstituted indol-2-one derivatives of the general Formula (I) | 11-12-2009 |
20090306144 | PYRIDINE DERIVATIVES OF ALKYL OXINDOLES AS 5-HT7 RECEPTOR ACTIVE AGENTS - New 3,3-disubstituted indol-2-one derivatives of the general formula (I) | 12-10-2009 |
20100075975 | MEDICAMENT FOR THE ENHANCEMENT OF COGNITIVE FUNCTION AND NEUROPROTECTION - The invention relates the use of 4-chloro-5-{2-[4-(6-fluoro-1,2-benz[d]isoxazole-3-yl)piperidin-1-yl]ethyl-amino}-2-methyl-3-(2H) pyridazinone of the Formula (I) | 03-25-2010 |
20120252784 | 2,3,4-BENZOTHIADIAZEPINE-2,2-DIOXIDE DERIVATIVES - Novel 2,3,4-benzothiadiazepines-2,2-dioxides and processes for the preparation thereof are disclosed. The compounds influence the central nervous system and may be used to treat or prevent Alzheimer's disease, Parkinson's disease or Huntington's disease, senile dementia not of the Alzheimer's type, vascular dementia, post-stroke dementia, Korsakoff's syndrome, Down's syndrome, schizophrenia, panic disorder, post-traumatic stress disorder, anxiety or depression. | 10-04-2012 |
Patent application number | Description | Published |
20140135503 | NOVEL PROCESSES FOR THE PREPARATION OF PROSTAGLANDIN AMIDES - The subject of the invention is process for the preparation of the prostaglandin amides of the general formula I, where in the formula the bonds marked with dotted lines may be single or double bonds, in the case of double bounds at positions 5,6 and 13,14 they may be in cis or in trans orientation, Q stands for a hydroxyl-group and Z stands for a hydroxyl- or oxo-group, R | 05-15-2014 |
20140343299 | PROCESS FOR THE PREPARATION OF TRAVOPROST - The invention relates to a process for the preparation of travoprost of formula (I), comprising that, the compound of formula (II), is stereo selectively reduced, the resulting compound of formula (III), is if desired crystallized, the lactone group of the compound of formula (III) is reduced, the p-phenyl-benzoyl protecting group of the thus obtained compound of formula (IV), is removed, the resulting triol of formula (V), is, if desired after crystallization, transformed by Wittig reaction into the acid of formula (VI), which is then esterified. | 11-20-2014 |
20150291503 | PROCESS FOR THE PREPARATION OF TRAVOPROST - The subject of the invention is process the preparation of travoprost of formula (I) characterized by that the free acid of formula (II) is a.) activated with 2-chloro-1,3-dimethyl-imidazolinium chloride (DMC) and the resulting activated carboxylic acid intermediate is reacted with isopropyl alcohol, or b.) reacted with alkyl haloformate and the resulting mixed anhydride is reacted with isopropyl alcohol, or c.) activated with a straight or branched C1-8 dialkyl dicarbonate and reacted with isopropanol in the presence of water-free magnesium salt. | 10-15-2015 |
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20130202706 | NANOSTRUCTURED ATORVASTATIN, ITS PHARMACEUTICALLY ACCEPTABLE SALTS AND COMPOSITIONS OF THEM, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM - The present invention is directed to nanostructured Atorvastatin, its pharmaceutically acceptable salts and compositions of them, process for the preparation thereof and pharmaceutical compositions containing them. The nanoparticles of Atorvastain, its pharmaceutically acceptable salts and compositions of them according to the invention have an average particle size of less than about 600 nm. The stable amorphous nanostructured particles of the present invention are characterized by increased solubility and bioequivalent biological performance compared to the marketed crystalline drug. Atorvastatin is a member of the drug class known as statins, used for lowering blood cholesterol. It also stabilizes plaque and prevents strokes through anti-inflammatory and other mechanisms. | 08-08-2013 |
20130209521 | NANOSTRUCTURED APREPITANT COMPOSITIONS, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM - The present invention is directed to nanostructured Aprepitant compositions, process for the preparation thereof and pharmaceutical compositions containing them. The nanoparticles of Aprepitant according to the invention have an average particle size of less than about 200 nm. The stable nanostructured particles of the invention are presented by increased solubility, dissolution rate, permeability and bioequivalent or enhanced biological performance characterized by significantly decreased fed/fasted effect compared to the reference and marketed drug. Aprepitant is a chemical compound that belongs to a class of drugs called substance P antagonists (SPA). It mediates its effect by acting on neurokinin 1 receptor. Aprepitant is manufactured by Merck & Co. under the brand name Emend for prevention of acute and delayed chemotherapy-induced nausea and vomiting (CINV) and for prevention of postoperative nausea and vomiting. | 08-15-2013 |
20130210794 | NANOSTRUCTURED EZETIMIBE COMPOSITIONS, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM - The present invention is directed to nanostructured Ezetimibe compositions, process for the preparation thereof and pharmaceutical compositions containing them. The nanoparticles of Ezetimibe according to the invention have an average particle size of less than about 400 nm. The stable nanostructured particles of the invention are presented by increased solubility, dissolution rate, permeability and bioequivalent or enhanced biological performance compared to the marketed drug. Ezetimibe is an anti-hyperlipidemic medication that is used to lower cholesterol levels. It acts by decreasing cholesterol absorption in the intestine. | 08-15-2013 |
Patent application number | Description | Published |
20130202706 | NANOSTRUCTURED ATORVASTATIN, ITS PHARMACEUTICALLY ACCEPTABLE SALTS AND COMPOSITIONS OF THEM, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM - The present invention is directed to nanostructured Atorvastatin, its pharmaceutically acceptable salts and compositions of them, process for the preparation thereof and pharmaceutical compositions containing them. The nanoparticles of Atorvastain, its pharmaceutically acceptable salts and compositions of them according to the invention have an average particle size of less than about 600 nm. The stable amorphous nanostructured particles of the present invention are characterized by increased solubility and bioequivalent biological performance compared to the marketed crystalline drug. Atorvastatin is a member of the drug class known as statins, used for lowering blood cholesterol. It also stabilizes plaque and prevents strokes through anti-inflammatory and other mechanisms. | 08-08-2013 |
20130209521 | NANOSTRUCTURED APREPITANT COMPOSITIONS, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM - The present invention is directed to nanostructured Aprepitant compositions, process for the preparation thereof and pharmaceutical compositions containing them. The nanoparticles of Aprepitant according to the invention have an average particle size of less than about 200 nm. The stable nanostructured particles of the invention are presented by increased solubility, dissolution rate, permeability and bioequivalent or enhanced biological performance characterized by significantly decreased fed/fasted effect compared to the reference and marketed drug. Aprepitant is a chemical compound that belongs to a class of drugs called substance P antagonists (SPA). It mediates its effect by acting on neurokinin 1 receptor. Aprepitant is manufactured by Merck & Co. under the brand name Emend for prevention of acute and delayed chemotherapy-induced nausea and vomiting (CINV) and for prevention of postoperative nausea and vomiting. | 08-15-2013 |
20130210794 | NANOSTRUCTURED EZETIMIBE COMPOSITIONS, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM - The present invention is directed to nanostructured Ezetimibe compositions, process for the preparation thereof and pharmaceutical compositions containing them. The nanoparticles of Ezetimibe according to the invention have an average particle size of less than about 400 nm. The stable nanostructured particles of the invention are presented by increased solubility, dissolution rate, permeability and bioequivalent or enhanced biological performance compared to the marketed drug. Ezetimibe is an anti-hyperlipidemic medication that is used to lower cholesterol levels. It acts by decreasing cholesterol absorption in the intestine. | 08-15-2013 |
Patent application number | Description | Published |
20140127194 | COMBINED PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF TUMORS - The invention relates to the use deuterium depleted water (DDW) for the preparation of combined pharmaceutical compositions for the prevention or treatment of tumorous diseases, where the composition comprises DDW with deuterium content of 0.01 to 135 ppm and one or more antineoplastic agent(s), optionally together with one or more usual pharmaceutical auxiliary material(s). Further, the invention relates to pharmaceutical compositions for adjuvant treatment of tumorous diseases, where the composition comprises DDW with deuterium content of 0.01 to 135 ppm and one or more antineoplastic agent(s), optionally together with one or more usual pharmaceutical auxiliary material(s). The invention also relates to aqueous pharmaceutical compositions usually applied in curing where the aqueous component is DDW with deuterium content of 0.01 to 135 ppm. | 05-08-2014 |
20140141095 | USE OF DEUTERIUM DEPLETED WATER FOR THE TREATMENT OF INSULIN RESISTANCE - The invention relates deuterium depleted water containing 0.01 to 135 ppm deuterium, preferably 105 to 125 ppm deuterium, for use in the treatment of insulin resistance. | 05-22-2014 |
20140158520 | PROCESS AND APPARATUS FOR THE SEPARATION OF THE COMPONENTS OF A LIQUID MIXTURE - Process and apparatus for the separation of the components having different boiling points of a liquid mixture, characterized in that forming bubbles by a carrier gas in the liquid mixture where the one or more volatile component is getting enriched in the bubbles, then after said bubbles leave the liquid phase the released vapor content of them is collected and condensed and the obtained liquid being enriched in the more volatile component(s) is separated from the carrier gas. | 06-12-2014 |
Patent application number | Description | Published |
20100172293 | Lightweight Mobility Architecture - Mobility between access domains in an Internet Protocol (IP) network can be supported by introducing a so-called Mobility Manager (MM) that maintains a database of currently attached devices and their current access domain location. The mobility manager may then detect, for a device registered in the database, a change of access domain from a first access domain to a second access domain by monitoring connection maintenance signaling related to the considered device. The mobility manager should at least obtain an indication of such a change of access domain. In response to a detected change of access domain, the mobility manager arranges for a reconfiguration of the network to forward traffic destined to an IP address of the device in the first access domain to a new location in the second access domain. In this way, the mobility manager allows the device to keep its IP address when moving between access domains. | 07-08-2010 |
20100226278 | METHOD AND MONITORING COMPONENT FOR NETWORK TRAFFIC MONITORING - A technique for traffic monitoring in a network comprising monitoring components and a management center (MC) is described. A method implementation comprises the steps of selecting a first set of local identifiers from a larger second set of local identifiers, wherein the local identifiers are capable of providing a unique identification of a network connection at the first monitoring component, filtering network connections, allocating a local identifier of the first set of local identifiers to a network connection in case a filter condition applies during the filtering, checking associations of network traffic with local identifiers, and selectively monitoring network traffic associated with a local identifier from the first set of local identifiers. | 09-09-2010 |
20120203864 | Method and Arrangement in a Communication Network for Selecting Network Elements - An arrangement and method for selecting one or more network elements of a communication network from which a requested content is to be downloadable to a requesting host is based on an enhanced DNS functionality which is adapted to provide an optimized network element selection. A received address resolving request results in a process for selectively identifying and acquiring topology related network information, which is using the acquired information as a basis for selecting one or more network elements. Addresses are then resolved for the selected network element/s, and the obtained addresses are provided to the requesting host in response to the request. | 08-09-2012 |