Patent application number | Description | Published |
20100083843 | SYSTEM AND METHOD FOR PREPARING A LIQUID BEVERAGE FROM A CARTRIDGE - A system and device for preparing a liquid beverage from a cartridge. The device includes a supply unit for supplying an injection fluid into the cartridge, a cartridge holder configured to accept and support the cartridge with the cartridge holder being detachable from the device. A complementary insertion mechanism of the device is configured to receive the cartridge holder in the device. The cartridge is positioned in the supply unit in an injection position with its injection surface substantially in an inclined plane relative to the horizontal plane and the injection mechanism is offset from the highest edge of the cartridge. The cartridge holder preferably comprises a linear wedge-shaped insertion member having a bearing surface inclined along an angle. The method of operation of the system and device are also disclosed. | 04-08-2010 |
20100107889 | DEVICE FOR PREPARING A LIQUID BEVERAGE FROM A CARTRIDGE - Device for preparing a liquid beverage from a cartridge, comprising a supply unit ( | 05-06-2010 |
20100263546 | SYSTEM FOR PREPARING A BEVERAGE FROM INGREDIENTS SUPPORTED BY AN ENCODED INSERT - The invention proposes a device for preparing a beverage from a food substance contained in a capsule ( | 10-21-2010 |
20100269706 | DEVICE FOR PREPARING A BEVERAGE WITH REMOVABLE INJECTION MEMBER - The invention proposes a device for preparing a beverage from a food substance contained in a capsule by injection of a liquid into the capsule provided to the device, said device comprising an extraction head ( | 10-28-2010 |
20100275787 | DEVICE FOR PREPARING A BEVERAGE COMPRISING AN ADJUSTABLE CLOSING MECHANISM - The present invention proposes a device ( | 11-04-2010 |
20110271840 | TRANSPORTABLE STAND-ALONE MACHINE FOR PREPARING A DRINK - Machine for preparing a drink, which comprises a casing ( | 11-10-2011 |
20110271841 | INJECTION ASSEMBLY AND MACHINE FOR PREPARING A DRINK PROVIDED WITH THIS INJECTION ASSEMBLY - Injection assembly ( | 11-10-2011 |
20120012007 | TRANSPORTABLE COMPACT MACHINE FOR PREPARING A DRINK - Machine for preparing a drink, which comprises a body ( | 01-19-2012 |
20120015080 | CAPSULE WITH FILTER FOR PREPARING A LIQUID NUTRITIONAL OR FOOD COMPOSITION AND RELATED BEVERAGE PRODUCTION SYSTEM - A capsule for use in a beverage production device, the capsule containing ingredients to produce a nutritional or food liquid when a liquid is fed into the capsule at an inlet face thereof, with the capsule being provided with a filter having a plurality of filtering orifices and a flow collection member placed downstream of the filter to collect the filtered liquid from the filtering orifices. The collection member includes at least one restriction orifice to focus the flow of liquid in at least one jet of liquid at high velocity in the compartment containing the ingredients. The invention is particularly advantageous for producing a nutritional liquid (e.g., infant formula) or a food from powdered ingredients. | 01-19-2012 |
20130036815 | BEVERAGE MACHINE WITH INTEGRATED ULTRASONIC TRANSCEIVER - The present invention discloses a beverage machine ( | 02-14-2013 |
20130118360 | CAPSULE HOLDER OR AN ADAPTER FOR ADAPTING A CAPSULE IN A CAPSULE HOLDER IN A BEVERAGE PREPARATION MACHINE - The present invention relates to a capsule holder ( | 05-16-2013 |
20130122157 | CAPSULE FOR THE PREPARATION OF A FOOD PRODUCT IN A FOOD PREPARATION MACHINE AT HIGH PRESSURE - The present invention relates to a capsule for delivering a food product by injection of a fluid under pressure into the capsule, said capsule comprising a chamber defined by capsule side walls, a flexible bottom wall and a top wall, said chamber containing at least one ingredient to be dissolved and/or extracted by said injection fluid, and a beverage dispensing structure comprising at least one dispensing opening disposed through the bottom wall, wherein said beverage dispensing structure comprises a pressure retaining element adapted to retain a certain predetermined dissolution and/or extraction pressure in the chamber, disposed in the vicinity of the bottom wall, which comprises a protrusion in correspondence to the dispensing opening so that said protrusion is disposed into the corresponding opening and restricts its diameter at the time injection fluid inside the capsule chamber moves said membrane towards said pressure retaining means. | 05-16-2013 |
20140023764 | SYSTEM AND METHOD FOR PREPARING A LIQUID BEVERAGE FROM A CARTRIDGE - A system and device for preparing a liquid beverage from a cartridge. The device includes a supply unit for supplying an injection fluid into the cartridge, a cartridge holder configured to accept and support the cartridge with the cartridge holder being detachable from the device. A complementary insertion mechanism of the device is configured to receive the cartridge holder in the device. The cartridge is positioned in the supply unit in an injection position with its injection surface substantially in an inclined plane relative to the horizontal plane and the injection mechanism is offset from the highest edge of the cartridge. The cartridge holder preferably comprises a linear wedge-shaped insertion member having a bearing surface inclined along an angle. The method of operation of the system and device are also disclosed. | 01-23-2014 |
20140109772 | DEVICE FOR PREPARING A LIQUID BEVERAGE FROM A CARTRIDGE - Device for preparing a liquid beverage from a cartridge, comprising a supply unit ( | 04-24-2014 |
20140352547 | SYSTEM FOR PREPARING A BEVERAGE FROM INGREDIENTS SUPPORTED BY AN ENCODED INSERT - The invention proposes a device for preparing a beverage from a food substance contained in a capsule ( | 12-04-2014 |
20140373723 | BEVERAGE PREPARATION SYSTEM - The present invention concerns a beverage preparation machine ( | 12-25-2014 |
20150040768 | SYSTEM FOR PREPARING A BEVERAGE FROM INGREDIENTS SUPPORTED BY AN ENCODED INSERT - The invention proposes a device for preparing a beverage from a food substance contained in a capsule ( | 02-12-2015 |
Patent application number | Description | Published |
20100099616 | MODIFIED BLOOD FACTORS COMPRISING A LOW DEGREE OF WATER SOLUBLE POLYMER - The present invention relates, in general, to materials and methods for the preparation of modified blood factors which have low levels of water soluble polymer molecules conjugated to the blood factor but exhibit biological activity similar to or better than molecules having a higher number of water soluble polymer moieties. | 04-22-2010 |
20100112607 | METHODS FOR DETERMINING ACTIVE INGREDIENTS IN PRO-DRUG PEG PROTEIN CONJUGATES WITH RELEASABLE PEG REAGENTS (IN VITRO DE-PEGYLATION) - The invention relates to the development of in vitro assay systems that force the release of a water-soluble polymer, such as polyethylene glycol (PEG) and polysialic acid (PSA), from proteins modified with a reversibly-linked water-soluble polymer. The invention includes methods for analyzing the release of the water-soluble polymer and measuring regained protein activity. The invention further includes methods appropriate for the quality control of proteins modified with releasable water-soluble polymers, including polymers like PEG and PSA. | 05-06-2010 |
20100143957 | METHODS OF MEASURING ADAMTS13-MEDIATED IN VIVO CLEAVAGE OF VON WILLEBRAND FACTOR AND USES THEREOF - The invention generally relates to methods of measuring cleaved von Willebrand factor (VWF) fragments. More specifically, the invention relates to methods of measuring the ability of a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13) to cleave VWF in vivo. The invention also relates to methods of using various animal models which demonstrate ADAMTS13 activity similar to that of a human. The invention further relates to methods of measuring the cleavage products of rVWF in mammals, particularly in humans and in human plasma. | 06-10-2010 |
20110027350 | GLYCOPOLYSIALYLATION OF NON-BLOOD COAGULATION PROTEINS - A water soluble polymer, in particular polysialic acid (PSA) or a modified PSA (mPSA), is conjugated to an oxidized carbohydrate moiety of a glycoprotein other than a blood coagulation protein or to a ganglioside or drug delivery system by contacting the oxidized carbohydrate moiety with the water soluble polymer, wherein said water soluble polymer contains an aminooxy group and an oxime linkage is formed between the oxidized carbohydrate moiety and the aminooxy group on the water soluble polymer or wherein said water soluble polymer contains a hydrazide group and a hydrazone linkage is formed between the oxidized carbohydrate moiety and the hydrazide group on the water soluble polymer. Conjugates of aminooxy- or hydrazide-water soluble polymer, such as PSA and mPSA, are thus obtained in which the PSA or mPSA is attached via a carbohydrate moiety. | 02-03-2011 |
20110028693 | BLOOD COAGULATION PROTEIN CONJUGATES - The invention relates to materials and methods of conjugating a water soluble polymer to an oxidized carbohydrate moiety of a blood coagulation protein comprising contacting the oxidized carbohydrate moiety with an activated water soluble polymer under conditions that allow conjugation. More specifically, the present invention relates to the aforementioned materials and methods wherein the water soluble polymer contains an active aminooxy group and wherein an oxime linkage is formed between the oxidized carbohydrate moiety and the active aminooxy group on the water soluble polymer. In one embodiment of the invention the conjugation is carried out in the presence of the nucleophilic catalyst aniline. In addition the generated oxime linkage can be stabilized by reduction with NaCNBH | 02-03-2011 |
20120035344 | NUCLEOPHILIC CATALYSTS FOR OXIME LINKAGE - The invention relates to materials and methods of conjugating a water soluble polymer to an oxidized carbohydrate moiety of a therapeutic protein comprising contacting the oxidized carbohydrate moiety with an activated water soluble polymer under conditions that allow conjugation. More specifically, the present invention relates to the aforementioned materials and methods wherein the water soluble polymer contains an active aminooxy group and wherein an oxime or hydrazone linkage is formed between the oxidized carbohydrate moiety and the active aminooxy group on the water soluble polymer, and wherein the conjugation is carried out in the presence of a nucleophilic catalyst. | 02-09-2012 |
20120076749 | Modified Blood Factors Comprising a Low Degree of Water Soluble Polymer - The present invention relates, in general, to materials and methods for the preparation of modified blood factors which have low levels of water soluble polymer molecules conjugated to the blood factor but exhibit biological activity similar to or better than molecules having a higher number of water soluble polymer moieties. | 03-29-2012 |
20120190096 | MATERIALS AND METHODS FOR CONJUGATING A WATER SOLUBLE FATTY ACID DERIVATIVE TO A PROTEIN - The invention relates to materials and methods of conjugating a water soluble fatty acid derivative to a therapeutic protein comprising contacting the therapeutic protein with an activated water soluble fatty acid derivative under conditions that allow conjugation. | 07-26-2012 |
20120315650 | DETECTION OF CIRCULATING ADAMTS13-ANTIBODY COMPLEXES - The present invention relates to methods and means for detecting ADAMTS13 immune complexes in a sample. The methods include the steps of capturing and labelling immune complexes of anti-ADAMTS13 antibodies. Capturing and labelling may be achieved by two different binding units targeting the immune complexes. The invention further relates to diagnosing diseases associated with immunologic ADAMTS13 dysfunction like TTP (thrombotic thrombocytopenic purpura). | 12-13-2012 |
20120329127 | THERAPEUTIC PROTEINS WITH INCREASED HALF-LIFE AND METHODS OF PREPARING SAME - The present disclosure relates to materials and methods of conjugating a water soluble polymer to a therapeutic protein. | 12-27-2012 |
20130011900 | NUCLEOPHILIC CATALYSTS FOR OXIME LINKAGE - The invention relates to materials and methods of conjugating a water soluble polymer to an oxidized carbohydrate moiety of a therapeutic protein comprising contacting the oxidized carbohydrate moiety with an activated water soluble polymer under conditions that allow conjugation. More specifically, the present invention relates to the aforementioned materials and methods wherein the water soluble polymer contains an active aminooxy group and wherein an oxime or hydrazone linkage is formed between the oxidized carbohydrate moiety and the active aminooxy group on the water soluble polymer, and wherein the conjugation is carried out in the presence of a nucleophilic catalyst. | 01-10-2013 |
20130252263 | METHODS OF MEASURING ADAMTS 13-MEDIATED IN VIVO CLEAVAGE OF VON WILLEBRAND FACTOR AND USES THEREOF - The invention generally relates to methods of measuring cleaved von Willebrand factor (VWF) fragments. More specifically, the invention relates to methods of measuring the ability of a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13) to cleave VWF in vivo. The invention also relates to methods of using various animal models which demonstrate ADAMTS13 activity similar to that of a human. The invention further relates to methods of measuring the cleavage products of rVWF in mammals, particularly in humans and in human plasma. | 09-26-2013 |
20130310546 | NUCLEOPHILIC CATALYSTS FOR OXIME LINKAGE AND USE OF NMR ANALYSES OF THE SAME - The invention relates to materials and methods of conjugating a water soluble polymer to an oxidized carbohydrate moiety of a therapeutic protein comprising contacting the oxidized carbohydrate moiety with an activated water soluble polymer under conditions that allow conjugation and analyzing the conjugation using 2D NMR analysis. More specifically, the present invention relates to the aforementioned materials and methods wherein the water soluble polymer contains an active aminooxy group and wherein an oxime or hydrazone linkage is formed between the oxidized carbohydrate moiety and the active aminooxy group on the water soluble polymer, and wherein the conjugation is carried out in the presence of a nucleophilic catalyst. | 11-21-2013 |
20140107320 | BLOOD COAGULATION PROTEIN CONJUGATES - The invention relates to materials and methods of conjugating a water soluble polymer to an oxidized carbohydrate moiety of a blood coagulation protein comprising contacting the oxidized carbohydrate moiety with an activated water soluble polymer under conditions that allow conjugation. More specifically, the present invention relates to the aforementioned materials and methods wherein the water soluble polymer contains an active aminooxy group and wherein an oxime linkage is formed between the oxidized carbohydrate moiety and the active aminooxy group on the water soluble polymer. In one embodiment of the invention the conjugation is carried out in the presence of the nucleophilic catalyst aniline. In addition the generated oxime linkage can be stabilized by reduction with NaCNBH | 04-17-2014 |
20140121351 | NUCLEOPHILIC CATALYSTS FOR OXIME LINKAGE - The invention relates to materials and methods of conjugating a water soluble polymer to an oxidized carbohydrate moiety of a therapeutic protein comprising contacting the oxidized carbohydrate moiety with an activated water soluble polymer under conditions that allow conjugation. More specifically, the present invention relates to the aforementioned materials and methods wherein the water soluble polymer contains an active aminooxy group and wherein an oxime or hydrazone linkage is formed between the oxidized carbohydrate moiety and the active aminooxy group on the water soluble polymer, and wherein the conjugation is carried out in the presence of a nucleophilic catalyst. | 05-01-2014 |
20140154709 | METHODS OF MEASURING ADAMTS 13-MEDIATED IN VIVO CLEAVAGE OF VON WILLEBRAND FACTOR AND USES THEREOF - The invention generally relates to methods of measuring cleaved von Willebrand factor (VWF) fragments. More specifically, the invention relates to methods of measuring the ability of a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13) to cleave VWF in vivo. The invention also relates to methods of using various animal models which demonstrate ADAMTS13 activity similar to that of a human. The invention further relates to methods of measuring the cleavage products of rVWF in mammals, particularly in humans and in human plasma. | 06-05-2014 |
20140271611 | SUBCUTANEOUS ADMINISTRATION OF ADAMTS13 - This invention relates to methods of subcutaneous administration of ADAMTS13 formulations to a treat a disease or condition associated with ADAMTS13 and VWF dysfunction. Furthermore, evidence of the unexpectedly high bioavailability of ADAMTS13 formulations administered subcutaneously is provided herein. | 09-18-2014 |
20150024455 | NUCLEOPHILIC CATALYSTS FOR OXIME LINKAGE - The invention relates to materials and methods of conjugating a water soluble polymer to an oxidized carbohydrate moiety of a therapeutic protein comprising contacting the oxidized carbohydrate moiety with an activated water soluble polymer under conditions that allow conjugation. More specifically, the present invention relates to the aforementioned materials and methods wherein the water soluble polymer contains an active aminooxy group and wherein an oxime or hydrazone linkage is formed between the oxidized carbohydrate moiety and the active aminooxy group on the water soluble polymer, and wherein the conjugation is carried out in the presence of a nucleophilic catalyst. | 01-22-2015 |