Danila
Daniel Danila, Jeannette, PA US
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20120034539 | HIGH EFFICIENCY AND RELIABLE FUEL CELL SYSTEM OPERATING AT NEAR 100% FUEL UTILIZATION - A fuel cell system | 02-09-2012 |
Daniel Danila, New York, NY US
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20150191792 | GENE EXPRESSION PROFILE ASSOCIATED WITH PROSTATE CANCER - Using an RT-PCR platform, detection of gene transcripts highly expressed in prostate tissue and expressed in peripheral blood mononuclear cells (PBMC) from patients with mCRPC can provide a more reliable and robust prediction of poor overall survival than that of CTC enumeration in mCRPC. Disclosed is the identification of five genes, KLK3, KLK2, HOXB13, GHRL2 and FOXA1, the detection of two (2) or more transcripts of which predicts overall poor survival. The test is performed on blood samples that have been collected in collection tubes that stabilize intracellular RNA, require minimal on-site processing and can be easily stored and shipped for subsequent extraction of total RNA from whole blood for RT-PCR. | 07-09-2015 |
Daniel C. Danila, New York, NY US
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20150240314 | GENES ASSOCIATED WITH DASATINIB SENSITIVITY - The invention relates to a method for the Cell Type specific labeling with Amino acid Precursors (CTAP). In particular, the disclosed method permits the incorporation of stable isotope-labeled amino acids into the proteome of a vertebrate cell that has been engineered to express an exogenous enzyme that enables the cell to produce an essential amino acid from its amino acid substrate. The method employs stable isotope-labeled amino acid substrate/precursors from which essential amino acids bearing the label are generated. The labeled amino acids generated by the transgenic cell not only supports growth but specifically labels proteins of the transgenic cell. Furthermore, the use of different populations of cells expressing different exogenous amino acid-producing enzymes permits differential labeling of the proteomes of the individual cell populations in multicellular environments. | 08-27-2015 |
Delia C. Danila, Memphis, TN US
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20100178326 | AMINOPHOSPHONATE CARRIERS FOR LIPOSOME-BASED DRUG RELEASE SYSTEMS - A novel class of carriers for liposome-based drug delivery and release systems is provided. Such carriers exhibit excellent compatibility with hydrophilic drug compounds as well as effective release upon transport through phospholipid bilayers of cell membranes. Furthermore, such carriers are non-cytotoxic, particularly in terms of contact with cell membranes themselves. As such, these carriers accord an excellent manner of transporting pharmaceutical and other like compounds and materials to a user's individual cells for delayed release thereof at the site necessary to effectuate proper treatment. Drug delivery materials including such carriers are encompassed within this invention, as well as the overall method of drug delivery and delayed release provided thereby. | 07-15-2010 |
Delia Cesara Danila, Houston, TX US
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20080286549 | Nanothin polymer films with selective pores and method of use thereof - A method of preparing nanothin polymer films having uniform and selectively sized pores utilizing pore forming templates. Lipids and pore forming templates are dissolved into a first solution. The solvent is removed thereby creating a lipid bilayer with pore forming templates dispersed throughout. The bilayer is hydrated and monomers and crosslinkers are added to create a second solution. A nanothin film with pore forming templates is created through polymerization of said second solution. The pore forming templates are dissolved into a third solution by addition of a chemical in which the pore forming template is soluble, but the lipid bilayer is insoluble. This third solution is separated from the mixture leaving a nanothin polymer film with pores of a uniform thickness and surface area. In summary, the guided assembly method presented here suggests a new general strategy for the fabrication of nanothin materials with controlled permeability, which provides improvements over the currently existing technology. | 11-20-2008 |
20100157286 | NANOTHIN POLYMER FILMS WITH SELECTIVE PORES AND METHOD OF USE THEREOF - A method of preparing nanothin polymer films having uniform and selectively sized pores utilizing pore forming templates. Lipids and pore forming templates are dissolved into a first solution. The solvent is removed thereby creating a lipid bilayer with pore forming templates dispersed throughout. The bilayer is hydrated and monomers and crosslinkers are added to create a second solution. A nanothin film with pore forming templates is created through polymerization of said second solution. The pore forming templates are dissolved into a third solution by addition of a chemical in which the pore forming template is soluble, but the lipid bilayer is insoluble. This third solution is separated from the mixture leaving a nanothin polymer film with pores of a uniform thickness and surface area. In summary, the guided assembly method presented here suggests a new general strategy for the fabrication of nanothin materials with controlled permeability, which provides improvements over the currently existing technology. | 06-24-2010 |
20130329215 | NANOTHIN POLYMER FILMS WITH SELECTIVE PORES AND METHOD OF USE THEREOF - One aspect of the invention provides a nanothin polymer film having a plurality of pores defined solely by polymers of the polymer film. The pores have a uniform size. Another aspect of the invention provides a method of using a polymer film capsule with pores defined solely by the film described herein. The method includes: separating a mixture of chemicals having variable surface areas from the polymer film capsule by using a size exclusion column; collecting the polymer film capsule eluate from the size exclusion column; and determining a content of chemicals retained in the polymer film capsule by using UV/vis spectroscopy. | 12-12-2013 |