Richard, MA
Amy Richard, Newton, MA US
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20090048717 | Multiple input building controller - Controllers associated with the high energy devices may are programmed or configured with processing rules by a building manager or an energy usage coordinator such that the controllers can respond to various changing conditions without having to be contacted by the energy usage controller. Such autonomous control allows the controllers to react more quickly to potentially take advantage of advantageous conditions and/or avoid disadvantageous conditions. For example, by tracking information from market information services and/or from historical, current and predicted information services, a controller may be programmed to reduce energy usage autonomously under a number of programmable conditions. | 02-19-2009 |
20090048718 | Multi-building control for demand response power usage control - An energy usage coordinator controls the energy usage of individual buildings of a group (or portfolio) of buildings in one or more load zones. These buildings have all contracted with an energy company which controls (directly or indirectly) the energy usage coordinator. By agreeing to lower energy usage during times of peak usage (when the energy company may otherwise have to pay very high prices on the spot or short term market), the owners or managers of the buildings receive a preferential energy rate from the energy company. Such a preferential rate may be in the form of a fixed rate reduction or a variable rate reduction. Alternatively, the energy company may determine that the energy is currently selling for twice what its building portfolio has contracted to pay for it so it requests some portion of the portfolio to reduce usage so that it can sell the excess/saved energy in the market. | 02-19-2009 |
20090048901 | Energy usage prediction and control system and method - A controller and/or a gateway acts as a feedback-based energy estimator for controlling initial and refined estimates of energy usage of one or more buildings controlled by the controller or gateway. An initial estimate of a building's energy needs for a specified time in the future (e.g., a month or a week ahead) are calculated, and then over time, in conjunction with an energy company, the initial estimate (and subsequent estimates) is revised based on the costs of the energy predicted or quoted by the energy company. The controller may examine jobs to be performed at the time as well as predictive information that may affect the building's energy needs (e.g., the predicted temperature for the time of the predicted energy needs). As expectations change (or as predicted factors such as temperature change), the energy company may be informed of the additional energy that will be needed (e.g., if the predicted temperature is increasing and cooling will be needed) or the excess energy that is expected (e.g., if the predicted temperature is decreasing and less cooling will be needed). | 02-19-2009 |
Bernard J. Richard, Dudley, MA US
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20140202998 | Laser Device and Method for Marking an Object - Laser device comprising at least two gas laser units ( | 07-24-2014 |
20140204713 | DEVICE AND METHOD FOR DETERMINATION OF A POSITION OF AN OBJECT BY MEANS OF ULTRASONIC WAVES - The invention refers to a device for determination of a position of an object by means ultrasonic waves, comprising at least one ultrasonic sensor for receiving ultrasonic signals from the object and computing means for computing the position of the object based on the received ultrasonic signals. At least one laser unit for generating a pulsed laser beam is provided, wherein said pulsed laser beam being directed to the object and adapted to cause at a surface of the object vibrations, by which the object is excited to generate ultrasonic signals. The invention also relates to a method for determination of a position of an object by means of ultrasonic waves, wherein by at least one ultrasonic sensor ultrasonic signals are received from the object, and based on the received ultrasonic signals, the position of the object is computed. A pulsed laser beam is generated by at least one laser unit, said laser beam is directed to the object and by means of the pulsed laser beam vibrations are caused at a surface of the object, wherein the object is excited to generate the ultrasonic signals. | 07-24-2014 |
20140209580 | Marking Apparatus with at Least One Gas Laser and Heat Dissipator - The invention relates to a marking apparatus for marking an object with laser light, which apparatus comprises at least one gas laser for emitting at least one laser beam for marking the object. The at least one gas laser comprises a plurality of resonator tubes ( | 07-31-2014 |
20140217072 | Marking Apparatus with a Plurality of Lasers and a Combining Deflection Device - The invention relates to a marking apparatus ( | 08-07-2014 |
20140217073 | Marking Apparatus with a Plurality of Lasers and Individually Adjustable Sets of Deflection Means - The invention relates to a marking apparatus for marking an object with laser light, comprising a plurality of lasers and a control unit for individually activating each of the lasers to emit a laser beam ( | 08-07-2014 |
20140233597 | Laser Device - The invention relates to a laser device comprising at least three linear laser gain volumes ( | 08-21-2014 |
20140247316 | Marking Apparatus - The invention relates to a marking apparatus ( | 09-04-2014 |
20140247845 | Laser Device and Method for Generating Laser Light - The invention refers to a laser device comprising a plurality of linear resonator tubes ( | 09-04-2014 |
20140253661 | MARKING DEVICE FOR MARKING AN OBJECT WITH MARKING LIGHT - The invention relates to a marking device for marking an object ( | 09-11-2014 |
Brennan Richard, Norton, MA US
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20150027066 | CURB ADAPTER - Provided is a curb adapter, comprising a first wall along a first direction of extension; a second wall along a second direction of extension that is different from the first direction of extension; and a corner support mechanism coupled at a corner that includes an edge of the first wall and an edge of the second wall. The corner support mechanism includes at least one fastener coupled to the edge of the first wall and at least one fastener coupled to the edge of the second wall. | 01-29-2015 |
Charlie Richard, Carlisle, MA US
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20130121984 | BIOMARKERS FOR SANFILIPPO SYNDROME AND USES THEREOF - The present invention provides biomarkers for efficient and accurate characterization of Sanfilippo syndrome. In particular, the present invention provides biomarkers differentially expressed in Sanfilippo syndrome. Those biomarkers, used alone or in combination, may permit more accurate robust characterization of Sanfilippo syndrome, resulting in more precise determination of the types and/or severity of the syndrome. In addition, inventive biomarkers according to the present invention can be used to effective monitor treatment response in Sanfilippo syndrome patients and/or to optimize treatment for Sanfilippo syndrome. | 05-16-2013 |
Cynthia Richard, Essex, MA US
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20150119261 | Enrichment of Target Sequences - Methods and compositions are provided for enriching for target sequences from a population of nucleic acids, that includes: combining in solution, a population of nucleic acids and a target isolation probe wherein the target isolation probe comprises an affinity binding domain; permitting a single stranded region of the target isolation probe to hybridize to all or a portion of a target sequence in the population of nucleic acids; selectively immobilizing the hybridized nucleic acids from the population containing the target sequences by associating the target isolation probe with a capture domain and removing unbound material; removing non-target sequences from the 3′ end of the target sequence by means of one or more 3′ exonucleases thereby generating a blunt ended duplex or a staggered end at the 3′ end of the target sequence; optionally ligating a 3′ duplex adaptor or a duplex end of a hairpin adaptor to the 3′ end of the target sequence and the 5′ end of the target isolation probe; extending the 3′ end of the target isolation probe to form a blunt end or a staggered end at the 5′ end of the target sequence suitable for ligating and ligating an adapter to the 5′ end of the target sequence and the 3′ extended end of the target isolation probe. | 04-30-2015 |
David Richard, Littleton, MA US
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20140221387 | COMPOSITIONS AND METHODS USEFUL FOR TREATING DISEASES - The present invention relates to a compositions for and methods of cancer treatment in which compounds of Formula I or Formula II. In some aspects, the treatment of B-cell Lymphoma or other hematopoietic cancers is encompassed. In other aspects, the invention provides methods for treating particular types of hematopoietic cancers, such as B-cell lymphoma, using a combination of one or more compounds of Formula I or Formula II. Combination therapy with, for example, a class of therapeutics known as 26S proteasome inhibitors, for example, Bortezomib, are also included. In another aspect the present invention relates to autoimmune treatment with compounds of Formula I or Formula II. In another aspect, this invention relates to methods for identifying compounds, for example, compounds of the BH3 mimic class, that have unique in vitro properties that predict in vivo efficacy against B-cell lymphoma tumors and other cancers as well as autoimmune disease. | 08-07-2014 |
20150133450 | METHODS AND COMPOSITIONS USEFUL FOR TREATING DISEASES INVOLVING BCL-2 FAMILY PROTEINS WITH QUINOLINE DERIVATIVES - The present invention relates to compositions and methods for cancer treatment comprising compounds of Formulae I, II, and III. In some aspects, the invention relates to the treatment of B-cell Lymphoma or other hematopoietic cancers. In other aspects, the invention provides methods for treating particular types of hematopoietic cancers, such as, for example, B-cell lymphoma, using a combination of one or more compounds of Formulae I, II, and III. Combination therapy with, for example, 26S proteasome inhibitors, such as, for example, Bortezomib, are also included. In another aspect the present invention relates to autoimmune treatment with compounds of Formulae I, II, and III. In another aspect, this invention relates to methods for identifying compounds, for example, compounds of the BH3 mimic class, that have in vitro properties that predict in vivo efficacy against B-cell lymphoma tumors and other cancers as well as autoimmune disease. | 05-14-2015 |
David James Richard, Littleton, MA US
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20120134959 | PYRIMIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES - The invention relates to pyrimidine compounds of the Formula I: or a pharmaceutically acceptable salt thereof, wherein the constituent variables are as defined herein, compositions comprising the compounds, and methods for making and using the compounds. | 05-31-2012 |
David J. J Richard, Littleton, MA US
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20150150869 | METHODS AND COMPOSITIONS USEFUL FOR TREATING DISEASES INVOLVING BCL-2 FAMILY PROTEINS WITH QUINOLINE DERIVATIVES - The present invention relates to compositions and methods for cancer treatment comprising compounds of Formulae I, II, and III. In some aspects, the invention relates to the treatment of B-cell Lymphoma or other hematopoietic cancers. In other aspects, the invention provides methods for treating particular types of hematopoietic cancers, such as, for example, B-cell lymphoma, using a combination of one or more compounds of Formulae I, II, and III. Combination therapy with, for example, 26S proteasome inhibitors, such as, for example, Bortezomib, are also included. In another aspect the present invention relates to autoimmune treatment with compounds of Formulae I, II, and III. In another aspect, this invention relates to methods for identifying compounds, for example, compounds of the BH3 mimic class, that have in vitro properties that predict in vivo efficacy against B-cell lymphoma tumors and other cancers as well as autoimmune disease. | 06-04-2015 |
Eric R. Richard, Lexington, MA US
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20110307331 | MONITORING CLICKSTREAM BEHAVIOR OF VIEWERS OF ONLINE ADVERTISEMENTS AND SEARCH RESULTS - An aspect of the present invention relates to tracking and analyzing a computer user's behavior after viewing a particular search result or a particular advertisement to assess the impact of having viewed the search result or advertisement. | 12-15-2011 |
Fabian Richard, Worcester, MA US
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20080249010 | Method Of Inducing Apoptosis In Lymphoid Cells - A two-stage, transcriptionally regulated apoptotic program has been discovered. In the first stage, IL-3 withdrawal results in transcriptional activation of the NGAL gene followed by synthesis and secretion of NGAL protein. In the second stage, secreted NGAL protein induces apoptosis in lymphoid cells by an autocrine mechanism. Based on this discovery, the invention provides a method of inducing apoptosis in a lymphoid cell in a mammal, e.g., a human patient. The invention includes administering a therapeutically effective amount of an NGAL polypeptide or NGAL-like polypeptide to a mammal. | 10-09-2008 |
Gary Richard, Brookline, MA US
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20100171505 | Supplemental air system for a portable, instrinsically safe, flame ionization detector (FID) device - A supplemental air system for a portable, intrinsically safe (IS), flame ionization detector (FID) device includes a portable, intrinsically safe, FID device and a supplemental air system coupled to the FID device configured to store compressed air and deliver a flow of regulated air to the FID device as needed. | 07-08-2010 |
20100171506 | Explosion-proof detector assembly for a flame ionization detector (FID) - An explosion-proof detector assembly for a flame ionization detector (FID) including an explosion-proof detector assembly enclosure configured to house the FID therein. A vent assembly coupled to the assembly enclosure includes a sintered metal frit configured to allow exhaust generated by the FID to vent from the detector assembly enclosure. A hydrogen supply line assembly coupled to the assembly enclosure includes a sintered metal frit configured to deliver a supply of hydrogen to the FID. A sample line assembly coupled to the enclosure includes a sintered metal frit configured to deliver a sample gas to the FID. A pressure relief assembly coupled to the assembly enclosure includes a sintered metal frit configured to ensure the pressure inside the detector assembly enclosure does not exceed a predetermined pressure. The sintered metal frit of the vent assembly, the hydrogen supply line assembly, the sample line assembly, and the pressure relief assembly are each configured to prevent a flame generated by the FID from contacting an explosive atmosphere outside the assembly enclosure, dissipate heat such that the temperature thereof does not exceed a predetermined temperature, and create an explosion-proof seal. An electrical conduit assembly is configured to house a plurality of data communication and power wires and is configured to prevent a flame generated by the FID from contacting an explosive atmosphere outside the detector assembly enclosure, dissipates heat such that the temperature of all surfaces thereof does not exceed a predetermined temperature, and creates an explosion-proof seal. | 07-08-2010 |
20100172796 | Metal hydride storage system for a portable, intrinsically safe, flame ionization detector (FID) device - A metal hydride storage system for a portable intrinsically safe (IS), flame ionization detector (FID) device includes a portable intrinsically safe FID device and a metal hydride storage vessel is coupled to the FID device configured to store a predetermined amount of compressed hydrogen at a predetermined low pressure and deliver the hydrogen gas to the FID device. | 07-08-2010 |
20100173185 | Battery pack assembly for an intrinsically safe device - A battery pack assembly for an intrinsically safe device including a housing assembly. A pair of opposing end caps coupled to the housing assembly is configured to align a plurality of cells in a predetermined orientation. A potting compound is disposed in the housing which completely encapsulates all the surfaces of the plurality of cells and provides a uniform thickness of potting compound about the cells. The potting compound is configured to dissipate heat generated by an internal short of one of the plurality of cells and/or heat generated by over-charging or under-charging one of said cells such that the temperature of any external surface of the battery pack assembly does not exceed a predetermined temperature and prevents a venting of one of the plurality cells within the potting compound. | 07-08-2010 |
Gary P. Richard, Danvers, MA US
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20110162511 | Kinetic energy enhanced drumstick - The present invention is an energy enhanced drumstick which provides substantially more kinetic energy per strike and produces a more vibrant sound and desired quality of resonance from a drumstick, all while still maintaining the most desirable features of the traditional drumstick design. This kinetic energy enhanced drumstick is the hybrid structural product of using two or more distinct materials having markedly differing densities which are permanently joined together to form a single unified construct. This hybrid structural product yields a kinetic energy enhanced drumstick comprised of at least one primary material having a first density at its tip end, and has at least one secondary substance having a second density which is greater than the first density of the primary material adjacent the butt end of the drumstick. | 07-07-2011 |
James G. Richard, Tolland, MA US
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20110030814 | SEQUENCER ASSEMBLY, SYSTEM AND METHOD - This invention pertains to a sequencer for controlling the distribution of fluid input into a tank to at least two outlets using a plurality of cells connected to actuate a respective floating outlet. Each of the cells has a relatively uniform construction comprising an enclosure and a float. Each enclosure has an inlet arranged at one end to allow fluid therein and offset openings at an opposite end. The enclosure also is configured to accept the float in an inner cavity and arranged so as to allow the fluid therein to cause said float to move within said enclosure. Each cell is further arranged in pairs of a lift cell and a trigger cell adapted to actuate a floating outlet. Each float has an inclined upper surface configured to transfer a ball through the offset openings as the fluid causes the float to rise and fall from each cycle of actuate a respective floating outlet. The sequencer being particularly adapted to a system and method for dosing a septic system having two or more disposal fields. | 02-10-2011 |
James G. Richard, East Otis, MA US
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20090175046 | OUTDOOR LIGHT APPARATUS AND ASSEMBLY - A lighting assembly and apparatus having a light fixture mounted using a tube and stake assembly; the tube is configured with a male receptacle formed of a pronged plug positioned vertically with the upper end flush with the earth; and the stake for insertion into the earth, the stake is configured with a female receptacle containing electrical contacts adapted to receive the pronged plug of the male receptacle. The female receptacle is adapted to have an open end so as to clear debris to the bottom of said stake. The light assembly and apparatus can be constructed from low cost, low voltage outdoor lights so as to provide ground level illumination of pathways, steps, and landscaping. | 07-09-2009 |
Joseph Richard, Bedford, MA US
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20090149777 | High performance coil wire - A high performance coil over-core guide wire. The guide wire incorporates a nickel-titanium core with a stainless steel coil to provide a wire with improved kink resistance and good pushability. | 06-11-2009 |
Joseph Ernest Richard, Bedford, MA US
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20090030468 | CEMENT-DIRECTING ORTHOPEDIC IMPLANTS - A cement-directing structure for use in cement-injection bone therapy includes a collapsible, self-restoring braided structure with regions of differential permeability to the bone cement. The regions of differential permeability may be provided by areas where the braided mesh density is greater or lesser than surrounding areas and/or by means of a baffle. After the structure is placed in a void within a bony structure, cement is injected into the interior of the structure then oozes out in preferred directions according to the locations of the regions of differential permeability. | 01-29-2009 |
20120165940 | CEMENT-DIRECTING ORTHOPEDIC IMPLANTS - A cement-directing structure for use in cement-injection bone therapy includes a collapsible, self-restoring braided structure with regions of differential permeability to the bone cement. The regions of differential permeability may be provided by areas where the braided mesh density is greater or lesser than surrounding areas and/or by means of a baffle. After the structure is placed in a void within a bony structure, cement is injected into the interior of the structure then oozes out in preferred directions according to the locations of the regions of differential permeability. | 06-28-2012 |
Matthew Richard, Holden, MA US
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20130145466 | System And Method For Detecting Malware In Documents - In one embodiment, a method includes identifying, using one or more processors, a plurality of characteristics of a Portable Document Format (PDF) file. The method also includes determining, using the one or more processors, for each of the plurality of characteristics, a score corresponding to the characteristic. In addition, the method includes comparing, using the one or more processors, the determined scores to a first threshold. Based at least on the comparison of the determined scores to the first threshold, the method includes determining, using the one or more processors, that the PDF file is potential malware. | 06-06-2013 |
20130145470 | DETECTING MALWARE USING PATTERNS - In certain embodiments, a method includes receiving a first file. The method also includes accessing at least one storage module comprising a first malware pattern, a second malware pattern, and a third malware pattern. The second malware pattern is a first permutation of the first malware pattern. The third malware pattern is a second permutation of the second malware pattern and is different than the second malware pattern. The method includes comparing, by at least one processor, the first file to the third malware pattern. In addition, the method includes determining, by the at least one processor, that the first file comprises malware in response to comparing the file to the third malware pattern. | 06-06-2013 |
20130145471 | Detecting Malware Using Stored Patterns - In one embodiment, a method includes identifying a plurality of portions of a file and comparing the plurality of portions of the file to a plurality of stored patterns. The plurality of stored patterns include portions of known malware. The method also includes determining, from the plurality of portions of the file and based on the comparing of the plurality of portions of the file to the plurality of stored patterns, a set of matching portions. The set of matching portions include one or more of the plurality of portions of the file. In addition, the method includes determining a score for each portion in the set of matching portions and providing information regarding the set of matching portions. The information includes the scores determined for each portion of the set of matching portions. | 06-06-2013 |
Nate Richard, Peabody, MA US
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20120044609 | Electrostatic Chuck With Polymer Protrusions - In accordance with an embodiment of the invention, there is provided an electrostatic chuck. The electrostatic chuck comprises a surface layer activated by a voltage in an electrode to form an electric charge to electrostatically clamp a substrate to the electrostatic chuck. The surface layer includes a plurality of polymer protrusions and a charge control layer to which the plurality of polymer protrusions adhere, the plurality of polymer protrusions extending to a height above portions of the charge control layer surrounding the plurality of polymer protrusions to support the substrate upon the plurality of polymer protrusions during electrostatic clamping of the substrate. | 02-23-2012 |
Robert Richard, Wrentham, MA US
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20090054965 | Methods For Producing Embolic Devices - A vascular implant is provided. The implant can comprise a first material layer and at least one metallic material disposed on at least a portion of the first material layer in a predetermined pattern. The implant can further comprise at least one hydrophobic material disposed on at least a portion of the surface of at least one of the first material layer and the at least one metallic material. | 02-26-2009 |
Robert E. Richard, Westwood, MA US
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20130164348 | MEDICAL DEVICES FOR DELIVERY OF THERAPEUTIC AGENTS - The present invention is generally directed to medical devices, and more specifically to medical devices that are at least partially insertable or implantable into the body of a patient. The medical devices generally comprise (a) a therapeutic agent, more typically, a high-molecular-weight therapeutic agent, and (b) at least one polymeric layer, which typically acts to control the release of the therapeutic agent from the medical device. Also disclosed herein are methods of making such medical devices. | 06-27-2013 |
Stephen E. Richard, Lynnfield, MA US
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20120263258 | CIRCUITS AND METHODS FOR PROVIDING A CONTROL VOLTAGE AND IMPROVING SWITCH PERFORMANCE IN RADIO FREQUENCY (RF) MODULES - An apparatus comprises at least one transmit amplifier and rectification circuitry located in the at least one transmit amplifier, which is configured to receive a RF signal and provide a rectified voltage, which is selectably added to a voltage supplied by a battery to generate a DC voltage supply signal that is a function of RF power level. A controller is configured to select between providing the VBAT or the VSupply signal to a transmit switch depending on one or more of a logic state and a mode of operation. An alternate apparatus comprises a charge pump circuit configured to quickly raise a voltage supplied to it and store the output voltage on a capacitor and then either shift a first frequency provided by a charge pump oscillator to a lower second frequency or turn off a charge pump clock to maintain a voltage on the capacitor during a transmit mode. | 10-18-2012 |
Thomas Richard, Peabody, MA US
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20140291936 | MATRIX SPLIT ROTARY SEAL - The present invention provides a rotary seal assembly for providing sealing on a rotating shaft or other suitable device. The seal assembly seals against a rotating shaft or other piece of moving equipment to prevent the leakage of fluids. In some embodiments, a split rotary seal assembly employing an energizer, housing, and a rotational seal element such as a matrix is provided. The energizer energizes the matrix to enhance the sealing properties of the assembly. Furthermore, the matrix conforms to the surface of the shaft, and moves radially with the shaft to provide an effective seal in high wear or runout applications. | 10-02-2014 |