Dai, MA
Andrew Dai, Acton, MA US
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20130074411 | Fuel Coupler with Wireless Port Door Unlatching Actuator - A fuel delivery system and method of use are provided that may be used to open the door covering the charge port of an electric vehicle, or the door covering the fuel filler port of a conventional vehicle. The system includes a fuel coupler (e.g., a charging connector or a gas nozzle) designed to transfer fuel from the source to the vehicle via the vehicle's fuel port. The fuel coupler includes a switch that when toggled, causes a control signal to be wirelessly transmitted over a short distance. Upon receipt of the control signal by a receiver integrated into a vehicle that is in close proximity to the fuel port, an unlatching actuator within the vehicle unlatches the port door, thereby allowing it to open and provide port access. | 03-28-2013 |
20130074985 | Vehicle Port Door with Wirelessly Actuated Unlatching Assembly - A port door unlatching system is provided that may be used to open the door covering the charge port of an electric vehicle, or the door covering the fuel filler port of a conventional vehicle. The system includes a fuel delivery subsystem with a fuel coupler (e.g., a charging connector or a gas nozzle) designed to transfer fuel from the source to the vehicle via the vehicle's fuel port. The fuel coupler includes a switch that when toggled, causes a control signal to be wirelessly transmitted over a short distance. Upon receipt of the control signal by a receiver integrated into a vehicle that is in close proximity to the fuel port, an unlatching actuator within the vehicle unlatches the port door, thereby allowing it to open and provide port access. | 03-28-2013 |
Chaoyang Dai, Acton, MA US
Patent application number | Description | Published |
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20090137586 | COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS - This invention relates to compounds of the Formula (I): | 05-28-2009 |
20090156586 | COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS - This invention relates to compounds of the Formula (I): | 06-18-2009 |
20090170875 | COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS - This invention relates to compounds of the Formula (I): | 07-02-2009 |
20100120838 | COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS - This invention relates to compounds of the Formula (I): | 05-13-2010 |
20100145048 | COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS - This invention relates to compounds of the Formula (I): | 06-10-2010 |
20110123435 | COMPOUNDS FOR INHIBITING KSP KINESIN ACTIVITY - The present invention relates to compounds of Formula (I), below, (wherein X, R1, R2, R3, p, E, ring A, and ring B are as defined herein). The present invention also relates to compositions (including pharmaceutically acceptable compositions) comprising these compounds, alone and in combination with one or more additional therapeutic agents, and to methods for their use in inhibiting KSP kinesin activity, and for treating cellular proliferative diseases or disorders associated with KSP kinesin activity. Formula I | 05-26-2011 |
20110150757 | COMPOUNDS FOR INHIBITING KSP KINESIN ACTIVITY - The present invention relates to compounds of Formula (I), below, (wherein R1, R2, R3, R27, R28, R29, p, E, ring A, and ring B are as defined herein). The present invention also relates to compositions (including pharmaceutically acceptable compositions) comprising these compounds, alone and in combination with one or more additional therapeutic agents, and to methods for their use in inhibiting KSP kinesin activity, and for treating cellular proliferative diseases or disorders associated with KSP kinesin activity. | 06-23-2011 |
20110171172 | COMPOUNDS FOR INHIBITING KSP KINESIN ACTIVITY - The present invention relates to compounds of Formula (I), below, (wherein R | 07-14-2011 |
20120010181 | COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS - This invention relates to compounds of the Formula (I): (Chemical formula should be inserted here as it appears on abstract in paper form) (I) or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF—or combinations thereof. | 01-12-2012 |
20120015926 | COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS - This invention relates to compounds of the Formula (I): (Chemical formula should be inserted here as it appears on abstract in paper form) (I) or a pharmaceutically acceptable salt thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF- or combinations thereof. | 01-19-2012 |
20120070370 | SPIRO 1,3,4-THIADIAZOLINE DERIVATIVES AS KSP INHIBITORS - The present invention relates to compounds of Formula (I), below, (wherein X, R1, R2, R3, p, ring A, and ring B are as defined herein). The present invention also relates to compositions (including pharmaceutically acceptable compositions) comprising these compounds, alone and in combination with one or more additional therapeutic agents, and to methods for their use in inhibiting KSP kinesin activity, and for treating cellular proliferative diseases or disorders associated with KSP kinesin activity. | 03-22-2012 |
20120322791 | PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS mTOR INHIBITORS - The present invention provides Pyrazolopyrimidine Compounds of Formula (I): | 12-20-2012 |
Guangping Dai, Action, MA US
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20090030618 | SYSTEM, METHOD AND SOFTWARE ARRANGEMENT FOR ANALYZING AND CORRELATING MOLECULAR PROFILES ASSOCIATED WITH ANATOMICAL STRUCTURES - A system, method and software arrangement according to exemplary embodiments of the present invention are provided which can use molecular profiles obtained from unaltered human tissue specimens for clinical purposes including disease diagnoses and treatment evaluations. For example, spatial distributions of chemical species including metabolites within the tissue may be obtained using radiological techniques such as magnetic resonance spectroscopy imaging. Disease-specific profiles may be obtained by comparing the distributions of chemical species obtained in ex vivo tissues with pathological observations made on them using statistical analysis. The disease-specific profiles may then be correlated with in vivo or ex vivo molecular profiles to obtain spatial maps that can provide a more sensitive and accurate detection of diseased tissue. Thus, such exemplary systems, methods and software arrangements can include the ability to receive information relating to the distribution of at least three chemical species in the tissue of interest, compare this information statistically to a predetermined profile and, based on the statistical correlation between the information and the profile, determine certain characteristics of the tissue of interest such as, e.g., the presence or absence of diseased tissue. | 01-29-2009 |
Haitao O. Dai, Boston, MA US
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20130241652 | UTILIZING A SENSE AMPLIFIER TO SELECT A SUITABLE CIRCUIT - Embodiments of the present invention provide an approach for utilizing a sense amplifier to select a suitable circuit, wherein a suitable circuit generates a voltage that is greater than or equal to a configurable reference voltage. An amplifier gain selector selects a voltage gain of a sense amplifier having input terminals, auxiliary inputs, an output, an array of resistive loads, and the amplifier gain selector. Auxiliary inputs are utilized to nullify direct current (DC) offset voltage of the sense amplifier. Combinatorial logic circuitry connects the input terminals of the sense amplifier to output terminals of a circuit that is within a group of circuits. A comparator circuit determines if the circuit generates a voltage greater than or equal to a configurable reference voltage, based on the output of the sense amplifier. | 09-19-2013 |
20140035670 | FET PAIR BASED PHYSICALLY UNCLONABLE FUNCTION (PUF) CIRCUIT WITH A CONSTANT COMMON MODE VOLTAGE - A FET pair based physically unclonable function (PUF) circuit with a constant common mode voltage and methods of use are disclosed. The circuit includes a first n-type field effect transistor (NFET) and a second NFET. The circuit also includes a first load resistor coupled to the first NFET by a first p-type field effect transistor (PFET) and a second load resistor coupled to the second NFET by a second PFET. The circuit further comprises a closed loop, wherein the closed loop creates a constant common mode voltage. | 02-06-2014 |
Han Dai, Cambridge, MA US
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20130102009 | SIRTUIN ACTIVATORS AND ACTIVATION ASSAYS - Provided are methods and compositions for detecting a compound that activates a sirtuin deacetylase activity on a fluorescent-free activation substrate in vitro. Further provided are sirtuin modulating compounds of the formulas (I)-(XXI), and related compounds (XXXI), (XXXII), (XXXIII), and (XXXIV), including the fluorescent free-substrate SIRT1 activator compounds of formulas (XL), (XI), (XII), and (XIII). | 04-25-2013 |
Hongyue Dai, Chestnut Hill, MA US
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20100169025 | METHODS AND GENE EXPRESSION SIGNATURE FOR WNT/B-CATENIN SIGNALING PATHWAY - Methods, biomarkers, and expression signatures are disclosed for assessing the regulation status of Wnt/β-catenin signaling pathway in a cell sample or subject. More specifically, several aspects of the invention provide a set of genes which can be used as biomarkers and gene signatures for evaluating Wnt/β-catenin pathway deregulation status in a sample; classifying a cell sample as having a deregulated or regulated Wnt/β-catenin signaling pathway; determining whether an agent modulates the Wnt/β-catenin signaling pathway in sample; predicting response of a subject to an agent that modulates the Wnt/β-catenin signaling pathway; assigning treatment to a subject; and evaluating the pharmacodynamic effects of therapies designed to regulate Wnt/β-catenin pathway signaling. | 07-01-2010 |
20100284915 | GENES ASSOCIATED WITH CHEMOTHERAPY RESPONSE AND USES THEREOF - The invention provides molecular markers that are associated with responsiveness of a cancer patient to a chemotherapy treatment, and methods and computer systems for determining such responsiveness based on measurements of these molecular markers. The present invention also provides methods and compositions for enhancing the efficacy of chemotherapies in patients by modulating the expression or activity of genes encoding these molecular markers and/or their encoded proteins. | 11-11-2010 |
20110166200 | METHODS OF USING MIR210 AS A BIOMARKER FOR HYPOXIA AND AS A THERAPEUTIC AGENT FOR TREATING CANCER - The present invention provides compositions and methods for predicting the hypoxia response in tumor cells, methods for predicting the likelihood of cancer metastasis, and methods for inhibiting tumor cell proliferation using a microRNA comprising miR-210. | 07-07-2011 |
20110294696 | METHODS FOR CHARACTERIZING AGONISTS AND PARTIAL AGONISTS OF TARGET MOLECULES - In one aspect, the present invention provides methods of determining whether an agent is more like a partial agonist of a target molecule than a full agonist of the same target molecule. In another aspect, the present invention provides methods to select a candidate compound that may reduce blood plasma glucose concentration in a mammal. Populations of genes are provided that are useful in the practice of the present invention. | 12-01-2011 |
20140030255 | METHODS OF PREDICTING CANCER CELL RESPONSE TO THERAPEUTIC AGENTS - In one aspect, methods, markers, and expression signatures are disclosed for assessing the degree to which a cell sample has epithelial cell-like properties or mesenchymal cell-like properties. In another aspect, methods are provided for predicting whether a subject with cancer will respond to treatment with an agent, based on whether the cancer is classified as having a high or low EMT Signature Score. | 01-30-2014 |
20140031251 | METHODS OF CLASSIFYING HUMAN SUBJECTS WITH REGARD TO CANCER PROGNOSIS - In one aspect, methods, markers, and expression signatures are disclosed for assessing the degree to which a cell sample has epithelial cell-like properties or mesenchymal cell-like properties. In another aspect, methods are provided for predicting cancer patient prognosis based on whether the cancer is classified as having a high or low EMT Signature Score. | 01-30-2014 |
Jianwu Dai, Boston, MA US
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20090162452 | EB Matrix Production From Animal Tissue And Its Use For Tissue Repair - A method of forming and preserving a bioremodelable, biopolymer scaffold material by subjecting animal tissue to chemical and mechanical processing. In addition to skin tissue, another source of EBM is a blood vessel. EBM may be used for hernia repair, colon, rectal, vaginal and or urethral prolapse treatment; pelvic floor reconstruction; muscle flap reinforcement; lung tissue support; rotator cuff repair or replacement; periosteum replacement; dura repair; pericardial membrane repair; soft tissue augmentation; intervertebral disk repair; and periodontal repair. EBM may also be used as a urethral sling, laminectomy barrier or spinal fusion device. | 06-25-2009 |
20150307836 | EB Matrix Production from Fetal Tissues and its Use for Tissue Repair - A method of performing and preserving a bioremodelable, biopolymer scaffold material by subjecting animal tissue to chemical and mechanical processing. In addition to skin tissue, another source of EBM is a blood vessel. EBM may be used for hernia repair, colon, rectal, vaginal and or urethral prolapse treatment; pelvic floor reconstruction; muscle flap reinforcement; lung tissue support; rotator cuff repair or replacement; periosteum replacement; dura repair; pericardial membrane repair; soft tissue augmentation; intervertebral disk repair; and periodontal repair. EBM may also be used as a urethral sling, laminectomy barrier or spinal fusion device. | 10-29-2015 |
Lian Dai, Lowell, MA US
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20120258444 | ACOUSTIC WAVE (AW) SENSING DEVICES USING LIVE CELLS - In one embodiment according to the invention, there is provided a method of sensing a response of a living cell or virus to a change in conditions. The method comprises applying an essentially constant external electromotive force that causes oscillation of an acoustic wave device at essentially constant amplitude and frequency under steady state conditions. The acoustic wave device has attached at least one living cell or virus. A combined oscillating system including the acoustic wave device and the living cell or virus exhibits a fundamental frequency and at least one harmonic frequency of the combined oscillating system. The living cell or virus is exposed to a change in an environmental condition while oscillating the combined oscillating system under the essentially constant external electromotive force, whereby a response of the living cell or virus to the change in environmental condition will be indicated by a change in at least one of frequency and amplitude of the oscillation of at least one harmonic frequency of the combined oscillating system. | 10-11-2012 |
20140087451 | ACOUSTIC WAVE (AW) SENSING DEVICES USING LIVE CELLS - In one embodiment according to the invention, there is provided a method of sensing a response of a living cell or virus to a change in conditions. The method comprises applying an essentially constant external electromotive force that causes oscillation of an acoustic wave device at essentially constant amplitude and frequency under steady state conditions. The acoustic wave device has attached at least one living cell or virus. A combined oscillating system including the acoustic wave device and the living cell or virus exhibits a fundamental frequency and at least one harmonic frequency of the combined oscillating system. The living cell or virus is exposed to a change in an environmental condition while oscillating the combined oscillating system under the essentially constant external electromotive force, whereby a response of the living cell or virus to the change in environmental condition will be indicated by a change in at least one of frequency and amplitude of the oscillation of at least one harmonic frequency of the combined oscillating system. | 03-27-2014 |
Lillian Lei Dai, Cambridge, MA US
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20080232344 | Systems and methods for synchronizing communication networks - In many aspects, the invention relates to systems and methods for synchronizing a communication network, particularly a slotted communication network, having a plurality of nodes. In slotted communication networks, the nodes are configured to transmit or receive data during selected time slots. During a selected time slot, each node transmits a synchronization message that is received by a neighboring node. The neighboring node adjusts its time slot boundary to coincide with the time of receipt of the synchronization message, thereby synchronizing each node with a neighboring node. Such systems and methods are energy efficient, accurate, fast, fault tolerant and easy to implement. | 09-25-2008 |
Miao Dai, Cambridge, MA US
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20110015232 | Pyrrolydine Derivatives as IAP Inhibitors - The present invention relates to novel IAP inhibitor compounds of: Formula (I). | 01-20-2011 |
20110065726 | Organic Compounds - The present invention is directed to a compound of the formula: | 03-17-2011 |
Mingjie Dai, Boston, MA US
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20150329584 | COMPOSITIONS AND METHODS RELATING TO COMPLEX NUCLEIC ACID NANOSTRUCTURES - The invention provides SST motifs of controlled size and shape, comprised of a plurality of oligonucleotides, and methods for their synthesis. The motifs are formed, at least in part, by the self-assembly of single stranded oligonucleotides into curved, corrugated or twisted structures. The location of each oligonucleotide in the resultant motif is known. Accordingly, the motifs may be modified with specificity. | 11-19-2015 |
Mingshi Dai, Billerica, MA US
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20080269217 | Melanocortin-4 receptor binding compounds and methods of use thereof - Provided are MC4-R binding compounds of the formula XVII: | 10-30-2008 |
20090275556 | Aryl sulfonamides useful as inhibitors of chemokine receptor activity - The present invention provides compounds of general formula I: | 11-05-2009 |
Nan Dai, Gloucester, MA US
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20140127677 | Compositions and Methods for the Transfer of a Hexosamine to a Modified Nucleotide in a Nucleic Acid - Nucleic acids comprising β-glucosaminyloxy-5-methylcytosine; compositions, kits and methods of producing the nucleic acids using a glycosyltransferase; and methods of using the nucleic acids are described. | 05-08-2014 |
20140127678 | Mapping Cytosine Modifications - Methods, compositions and kits for selectively altering and detecting modified cytosine residues are provided. | 05-08-2014 |
20140127683 | Compositions and Methods for Oxygenation of Nucleic Acids Containing 5-Methylpyrimidine - 5-methylpyrimidine oxygenases and their use in the modification of nucleic acids are described. | 05-08-2014 |
20150132750 | Compositions and Methods for Oxygenation of Nucleic Acids Containing 5-Methylpyrimidine - 5-methylpyrimidine oxygenases and their use in the modification of nucleic acids are described. | 05-14-2015 |
20150218530 | Compositions and Methods for Oxygenation of Nucleic Acids Containing 5-Methylpyrimidine - 5-methylpyrimidine oxygenases and their use in the modification of nucleic acids are described. | 08-06-2015 |
20160046981 | Compositions and Methods for the Transfer of a Hexosamine to a Modified Nucleotide in a Nucleic Acid - Nucleic acids comprising β-glucosaminyloxy-5-methylcytosine; compositions, kits and methods of producing the nucleic acids using a glycosyltransferase; and methods of using the nucleic acids are described. | 02-18-2016 |
Qi Dai, Peabody, MA US
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20150049444 | CONDUCTOR PAD FOR FLEXIBLE CIRCUITS AND FLEXIBLE CIRCUIT INCORPORATING THE SAME - A conductor pad and a flexible circuit including a conductor pad are provided. The conductor pad includes a first contact region, a second contact region, and a body portion configured to establish a conductive path between the first contact region and the second contact region. The body portion includes a perimeter edge having at least a first convex segment and a second convex with a first non-convex segment disposed between the first convex segment and the second convex segment. A method of constructing a flexible circuit to facilitate roll-to-roll manufacturing of the flexible circuit is also provided. | 02-19-2015 |
20160003670 | TECHNIQUES FOR LUMEN MAINTENANCE AND COLOR SHIFT COMPENSATION - Techniques are disclosed for maintaining consistent lumen output of a lighting assembly over time. By maintaining a consistent lumen output, it is possible to maintain acceptable color stability where color mixing of multiple outputs is used. The lighting assembly may be any lighting configuration that might suffer from lumen depreciation and/or color drift over time, and may include any type(s) of light source(s) that may be monitored and driven accordingly. The lighting assembly, in addition to light source(s), includes a photo detector and a directed light source, such as a laser. The directed light source provides a golden sample for use in calibrating the photo detector, which in turn monitors lumen output of the light source(s). Drive signals are adjusted to account for lumen depreciation of the monitored light source(s). | 01-07-2016 |
Qi Dai, Danvers, MA US
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20150233542 | BATWING OPTICS FOR INDIRECT LUMINAIRE - A luminaire is provided, that includes a housing and a plurality of solid state light sources connected thereto. The housing has a top side, two lateral sides, a protrusion in the top side, and two light source mounting surfaces. The top side is diffusely reflecting and has opposing lateral edges and a center. The lateral sides are specularly reflecting and extend generally downward from the opposing lateral edges of the top side. Each has a respective bottom edge. The light source mounting surfaces extend laterally inward from the respective bottom edges. The plurality of solid state light sources is disposed along the pair of light source mounting surfaces proximate the pair of specularly reflecting lateral sides. These emit light, which travels upward to the top side and is also specularly reflected by the lateral sides toward the top side. The top side diffusely reflects the light out of the luminaire. | 08-20-2015 |
20150327343 | PLANCKIAN AND NON-PLANCKIAN DIMMING OF SOLID STATE LIGHT SOURCES - Systems and methods of Planckian and non-Planckian dimming of solid state light sources are disclosed. For a given first range of correlated color temperature values on the 1931 CIE Chromaticity Diagram, the current through a plurality of solid state light sources is adjusted so that the light output thereby follows the correlated color temperature values relating to the black body curve over that given first range. For a given second range of correlated color temperature values, the current through a plurality of solid state light sources is adjusted so that the light output thereby deviates from black body curve and instead relates to a series of coordinates that tracks a line between the curve and a color point for one of the solid state light sources. | 11-12-2015 |
Wei Dai, St. Beileme, MA US
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20090150968 | Method and apparatus for managing and displaying contact authentication in a peer-to-peer collaboration system - Proper user-to-data associations are maintained in shared spaces created in a peer-to-peer collaborative system by means of a simplified and minimal user interface that permits users to easily authenticate other members of a shared space. In particular, support is provided for automatically building authenticated relationships even if users do not take the time to authenticate other users. When a user enters a shared space and views the contacts in that space, the display names of each contact are accompanied by distinctive icons that identify that authentication status of that contact. A mechanism is provided for resolving conflicts between contacts with the same display names to prevent confusion and contact “spoofing.” Security policies can be established to provide a uniform approach to authentication. These policies can be set by a user or, alternatively, the policies can be set by an administrator. | 06-11-2009 |
Wen Dai, Ashland, MA US
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20090233225 | Low chlorine epoxy resin formulations - This invention relates to the need to improve the corrosion resistance of very low total chlorine epoxy resins which contain very low contents of organically bound chlorine. The invention relates to the improvement of corrosion resistance of such epoxy resins for electronic applications by the addition of specific additives acceptable to the electronics industry. The use of these low chlorine resins in combination with said additives has been shown to be corrosion-free on highly corrosive surfaces such as aluminum and copper, which are frequently encountered in electronic applications. | 09-17-2009 |
Xiaochuan Dai, Somerville, MA US
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20160027846 | THREE-DIMENSIONAL NETWORKS COMPRISING NANOELECTRONICS - The present invention generally relates to nanoscale wires and three-dimensional networks or structures comprising nanoscale wires. For example, certain embodiments are directed to three-dimensional structures comprising nanoscale wires. The structures may be porous and define electrical networks wherein the nanoscale wires can be determined or controlled. Other materials, such as inorganic materials, polymers, fabrics, etc., may be disposed within the three-dimensional structure, and in some embodiments, such that the three-dimensional structure is embedded within the material. The nanoscale wires may thus be used, for example, as sensors within the material. Other embodiments of the invention are generally directed to the use of such articles, methods of forming such articles, kits involving such articles, or the like. | 01-28-2016 |
Xiaoshu Dai, Norwood, MA US
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20160046936 | BIODEGRADABLE AND CLINICALLY-COMPATIBLE NANOPARTICLES AS DRUG DELIVERY CARRIERS - The present invention relates to the composition of a nanoparticle based on a magnesium salt, and methods of drug delivery using the nanoparticle. A preferred embodiment uses magnesium phosphate, with or without a shell to deliver aiRNA and/or siRNA. The nanoparticles of the present invention are also effective when administered orally. | 02-18-2016 |
Xiaoshu Dai, Watertown, MA US
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20130177749 | NANOSTRUCTURES - A method for producing a matrix containing nanostructures. The method includes obtaining a layer having a thickness of 10 nm-100 μm, wherein the layer contains organic macromolecules arranged in a nanopattern, staining the layer with a solution containing a salt so that a portion of the salt is retained in the layer, and removing the organic mcaromolecules from the layer to form a matrix containing nanostructures. Also within the scope of this invention are nanostructures prepared by this method. | 07-11-2013 |
Yi Dai, Winchester, MA US
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20150077433 | ALGORITHM FOR IMPROVED ZOOMING IN DATA VISUALIZATION COMPONENTS - Example embodiments reduce the processing required to zoom on graphical data visualizations by transforming only graphic elements visible in the zooming viewport. In one example embodiment, a grid overlays the component image. Prior to zooming, grid elements covered by the zooming viewport are determined and only graphic objects bounded by those grid elements are transformed during zooming. | 03-19-2015 |
20150084961 | MAP PERFORMANCE BY DYNAMICALLY REDUCING MAP DETAIL - Example embodiments dynamically generate lower resolution maps from high precision vector for use on desktops. Lower resolution maps are dynamically generated on the client side by decreasing coordinate and path precision. | 03-26-2015 |
20150355817 | ENHANCED VISUAL NAVIGATION BREADCRUMBS - A system that provides visual components generates a first display of selectable and hierarchical visual components, where each visual component has at least one associated attribute. The system receives a selection of one of the visual components and displays a second display of visual components at a next hierarchical level of the selected visual component. The system then generates and displays breadcrumbs that include a navigation path from the first display to the second display, and include the associated attribute for the selected visual component. | 12-10-2015 |
20150363081 | INTERACTIVE MAP MARKERS - A system for providing an interactive map displays an interactive map marker that includes an associated location on the map, an associated data value, a visual indicator, and an underlying data model. The system receives an interaction from a user that modifies the visual indicator and changes the associated data value based on the visual indicator modification. The system then changes the underlying data model based on the visual indicator modification. | 12-17-2015 |
20150364118 | ATTRIBUTE BASED MAP MARKER CLUSTERING - A system that clusters map markers on a map receives a plurality of map markers, each having an associated location on the map and at least one attribute, and a characteristic corresponding to the attribute. The system location clusters the map markers based on the location within a cluster. The system then groups the clustered map markers based on the associated attribute, where each grouped marker retains the corresponding characteristic. The system then positions the grouped map markers within the corresponding cluster. | 12-17-2015 |
20150378526 | TILE VISUALIZATIONS FOR NAVIGATING HIERARCHICAL DATA ON MOBILE DEVICES - A tile visualization has a window with a swim lane area and a panel area for displaying tiles that represent hierarchical data items. Tiles may be styled as cards. The swim lane displays an active tile and its immediate ancestors in a row or column. The active tile may be identified by a visual indicator. The panel displays one or more levels of the active tile's descendants. The descendants may be arranged in a matrix, or in columns each headed by an immediate descendant. The swim lane and panel are scrollable. A user can navigate up in the hierarchy by activating a tile in the swim lane, or down by activating a tile in the panel. Users may select one or more tiles without activating them. | 12-31-2015 |
20150378528 | REFERENCE POSITION IN VIEWER FOR HIGHER HIERARCHICAL LEVEL - A system and method for facilitating preservation of context information during navigation of a visualization. An example method includes representing hierarchical data via an orbit visualization; providing a first user option to navigate to a child node selected from among the one or more child nodes of the orbit visualization; and updating the orbit visualization in response to user selection of the first user option, resulting in an updated orbit visualization, wherein the updated orbit visualization includes a parent node positioned at a periphery of the visualization, and wherein the selected child node is positioned as a new central node of the updated orbit visualization. A carousel control may be displayed concurrently with the orbit visualization, wherein the carousel control includes one or more user options to navigate to a previously navigated-to node of the orbit visualization. | 12-31-2015 |
20150378529 | INTERACTION IN ORBIT VISUALIZATION - A system and method for facilitating interacting with data and/or functionality via a visualization. An example method includes determining number of hierarchical levels to display in an orbit visualization; displaying the number of hierarchical levels via one or more nodes and one or more orbit paths, wherein each child node of a parent node of the one or more nodes is confined to one or more orbit paths that at least partially circumscribe the parent node; providing a first user option to navigate downward or upward in the hierarchy, at least in part via user selection of a node of the orbit visualization; and selectively updating the orbit visualization in response to user selection of the first user option so that a resulting updated visualization illustrates a navigated-to location, wherein the updated visualization illustrates the number of hierarchical levels. | 12-31-2015 |
20150378562 | CHAIN LAYOUT FOR DISPLAYING HIERARCHICAL DATA - A chain visualization shows cards representing first, second and third hierarchical data items from a database. The second data item descends from the first. The third descends from the second. The visualization shows an ancestors chain, a descendants chain, and an active item location where the chains meet. The visualization shows a card visually associated with the ancestors chain for the first data item, a card in the active item location for the second data item, and a card visually associated with the descendants chain for the third data item. The cards present information from the data items. When a card is activated, it moves to the active item location. A descendant data item, descending from the new active item, is retrieved from the database. A card representing the descendant data item is displayed as visually associated with the descendants chain. | 12-31-2015 |
20150378563 | ORBIT VISUALIZATION FOR DISPLAYING HIERARCHICAL DATA - A system and method for facilitating graphically conveying information via a visualization. An example method includes accessing a first set of data characterized by hierarchically related data objects; representing a first object as a first central node in a visualization; displaying one or more additional second objects via one or more second nodes that are positioned on a first orbit path around the central node; determining if an additional object of the one or more second objects exhibits a superior hierarchical relationship relative to one or more third objects; and then illustrating the one or more third objects as petals that are circumferentially displayed about one or more outer edges of one or more nodes of the one or more second objects. The example method further includes enabling conversion of petals to planet nodes that orbit one of the second nodes. | 12-31-2015 |
20150378564 | ORBIT VISUALIZATION ANIMATION - A system and method for transitioning a displayed visualization from a first state to a second state. An example method includes displaying an orbit visualization characterized by a first state, wherein the orbit visualization includes a parent node and one or more child nodes positioned about a first orbit path that at least partially circumscribes the parent node; selectively initiating navigation of the orbit visualization; transitioning display of the parent node and one or more child nodes in accordance with the navigation by animating repositioning of the parent node and the one or more child nodes on a user interface display screen, such that a resulting node positioning characterizes the orbit visualization in the second state representative of a navigated-to location. The navigation may represent a downward or upward navigation of hierarchically related data, such that the animation illustrates separation of one or more petals from a selected node or movement toward the selected node, respectively. | 12-31-2015 |
20150378580 | INTERACTION IN CHAIN VISUALIZATION - A chain visualization represents first, second and third hierarchical data items from a database. The second data item descends from the first. The third descends from the second. The visualization shows an ancestors chain and a descendants chain. It has an active item location where the chains meet. The visualization shows a card linked to the ancestors chain for the first data item, a card in the active item location for the second data item, and a card linked to the descendants chain for the third data item. Users may navigate upwards or downwards in the hierarchy by activating any card outside the active item location. Users may stack cards to save screen space, and users may scroll to view different parts of the hierarchy. Users may edit information from data items represented by the cards. | 12-31-2015 |
Yong Dai, Newton, MA US
Patent application number | Description | Published |
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20110021744 | PROCESS FOR PREPARING PURIFIED DRUG CONJUGATES - The invention provides a process for preparing a cell-binding agent chemically coupled to a drug. The process comprises covalently attaching a linker to a cell-binding agent, a purification step, conjugating a drug to the cell-binding agent and a subsequent purification step. | 01-27-2011 |
20130281678 | PROCESS FOR PREPARING PURIFIED DRUG CONJUGATES - The invention provides a process for preparing a cell-binding agent chemically coupled to a drug. The process comprises covalently attaching a linker to a cell-binding agent, a purification step, conjugating a drug to the cell-binding agent and a subsequent purification step. | 10-24-2013 |
20150182635 | PROCESS FOR PREPARING PURIFIED DRUG CONJUGATES - The invention provides a process for preparing a cell-binding agent chemically coupled to a drug. The process comprises covalently attaching a linker to a cell-binding agent, a purification step, conjugating a drug to the cell-binding agent and a subsequent purification step. | 07-02-2015 |
20160045616 | PROCESS FOR PREPARING PURIFIED DRUG CONJUGATES - The invention provides processes for preparing a cell-binding agent chemically coupled to a drug. A first process comprises covalently attaching a linker to a cell-binding agent, an optional purification step, conjugating a drug to the cell-binding agent, a subsequent purification step, and optional holding steps. A second process comprises covalently attaching a linker to a cell-binding agent, a purification step, conjugating a drug to the cell-binding agent, a subsequent purification step. holding steps, and optionally a tangential flow filtration (TFF) step. | 02-18-2016 |
Yong Dai, Northborough, MA US
Patent application number | Description | Published |
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20110166319 | PROCESS FOR PREPARING PURIFIED DRUG CONJUGATES - The invention provides processes for preparing a cell-binding agent chemically coupled to a drug. A first process comprises covalently attaching a linker to a cell-binding agent, an optional purification step, conjugating a drug to the cell-binding agent, a subsequent purification step, and optional holding steps. A second process comprises covalently attaching a linker to a cell-binding agent, a purification step, conjugating a drug to the cell-binding agent, a subsequent purification step, holding steps, and optionally a tangential flow filtration (TFF) step. | 07-07-2011 |