Patent application number | Description | Published |
20140259328 | MOISTURE-INSENSITIVE THERMALLY PROTECTIVE MATERIALS AND GARMENTS MADE THEREFROM - Protective garments and methods for low wet pick-up from hose water, weather, etc. and from perspiration generated by the wearer, to minimize water impact on the insulative properties, minimize weight gain, and effectuate quick drying. For firefighting in particular, the disclosure provides that wet, hot air is driven out of the garment, away from the wearer (rather than in), and water entry is blocked. | 09-18-2014 |
20140259331 | MOISTURE-INSENSITIVE THERMALLY PROTECTIVE MATERIALS AND GARMENTS MADE THEREFROM - Protective garments and methods for low wet pick-up from hose water, weather, etc. and from perspiration generated by the wearer, to minimize water impact on the insulative properties, minimize weight gain, and effectuate quick drying. For firefighting in particular, the disclosure provides that wet, hot air is driven out of the garment, away from the wearer (rather than in), and water entry is blocked. | 09-18-2014 |
Patent application number | Description | Published |
20110310698 | Dual Axis Geophones For Pressure/Velocity Sensing Streamers Forming a Triple Component Streamer - A seismic streamer includes a sensor comprises an axially oriented body including a plurality of axially oriented channels arranged in opposing pairs; a plurality of hydrophones arranged in opposing pairs in the channels; a pair of orthogonally oriented acoustic particle motion sensors; and a tilt sensor adjacent or associated with the particle motion sensors. The streamer has a plurality of hydrophones, as previously described, aligned with a plurality of accelerometers which detect movement of the streamer in the horizontal and vertical directions, all coupled with a tilt sensor, so that the marine seismic system can detect whether a detected seismic signal is a reflection from a geologic structure beneath the streamer or a downward traveling reflection from the air/seawater interface. | 12-22-2011 |
20120269033 | DUAL AXIS GEOPHONES FOR PRESSURE/VELOCITY SENSING STREAMERS FORMING A TRIPLE COMPONENT STREAMER - A seismic streamer includes a sensor comprises an axially oriented body including a plurality of axially oriented channels arranged in opposing pairs; a plurality of hydrophones arranged in opposing pairs in the channels; a pair of orthogonally oriented acoustic particle motion sensors; and a tilt sensor adjacent or associated with the particle motion sensors. The streamer has a plurality of hydrophones, as previously described, aligned with a plurality of accelerometers which detect movement of the streamer in the horizontal and vertical directions, all coupled with a tilt sensor, so that the marine seismic system can detect whether a detected seismic signal is a reflection from a geologic structure beneath the streamer or a downward traveling reflection from the air/seawater interface. | 10-25-2012 |
20130064038 | DUAL AXIS GEOPHONES FOR PRESSURE/VELOCITY SENSING STREAMERS FORMING A TRIPLE COMPONENT STREAMER - A seismic streamer includes a sensor comprises an axially oriented body including a plurality of axially oriented channels arranged in opposing pairs; a plurality of hydrophones arranged in opposing pairs in the channels; a pair of orthogonally oriented acoustic particle motion sensors; and a tilt sensor adjacent or associated with the particle motion sensors. The streamer has a plurality of hydrophones, as previously described, aligned with a plurality of accelerometers which detect movement of the streamer in the horizontal and vertical directions, all coupled with a tilt sensor, so that the marine seismic system can detect whether a detected seismic signal is a reflection from a geologic structure beneath the streamer or a downward traveling reflection from the air/seawater interface. | 03-14-2013 |
20140029377 | STREAMER FOR SEISMIC PROSPECTION COMPRISING TILT COMPENSATION OF DIRECTIONAL SENSORS - A streamer for seismic prospection comprising directional sensors ( | 01-30-2014 |
20150325336 | APPARATUS AND METHOD FOR AN ELECTRO-MECHANICAL CABLE OVERSTRESS INDICATOR - An apparatus for indicating overstress in an electro-mechanical cable. The apparatus includes an overstress an overstress indicator cable including at least one non-twisted conductor disposed within a section of the electro-mechanical cable, where the non-twisted conductor is adapted to break when tension in the non-twisted conductor is greater than an allowable working load for the electro-mechanical cable. | 11-12-2015 |
Patent application number | Description | Published |
20100166845 | INDIVIDUALIZED CANCER THERAPY - In certain embodiments, the invention provides methods for treating cancer, comprising: (a) obtaining a specimen of cancer tissue and normal tissue from a patient; (b) extracting total protein and RNA from the cancer tissue and normal tissue; (c) obtaining a protein expression profile of the cancer tissue and normal tissue; (d) identifying over-expressed proteins in the cancer tissue; (e) comparing the protein expression profile to a gene expression profile; (f) identifying at least one prioritized protein target by assessing connectivity of each said over-expressed protein to other cancer-related or stimulatory proteins; (g) designing a first RNA interference expression cassette to modulate the expression of at least one gene encoding the prioritized target protein; (h): designing a first RNA interference expression cassette to modulate the expression of at least one gene encoding a protein of higher priority in the signaling pathway in which the first protein is a component; (i) incorporating the first cassette into a first delivery vehicle; (j) providing a patient with an effective amount of the first delivery vehicle; (k) extracting total protein and RNA from the treated cancer tissue; (l) identifying over-expressed proteins in the treated cancer tissue; (m) designing a second RNA interference expression cassette to modulate the expression of a second prioritized protein in the treated tissue; (n) incorporating the second cassette into a second delivery vehicle; (o) providing the previously treated patient with an effective amount of the second delivery vehicle; (p) identifying a novel protein signal following prior treatment with protein specific knockdown; (q) identifying a gene mutation provided by gene sequencing/microarray on assessment of other protein signals; and (r) identifying of a novel protein signal as a result of determination of the gene mutation and assessment of other protein signals to, directly or indirectly, modify the expression (i.e., production) of such proteins. | 07-01-2010 |
20110027373 | METHODS AND COMPOSITIONS FOR MODULATING SIALIC ACID PRODUCTION AND TREATING HEREDITARY INCLUSION BODY MYOPATHY - According to certain embodiments of the present invention, methods for modulating the production of sialic acid in a system are provided, which comprise providing the system with a wild-type GNE-encoding nucleic acid sequence. According to such embodiments, the system may comprise a cell, muscular tissue, or other desirable targets. Similarly, the present invention encompasses methods for producing wild-type GNE in a system that comprises a mutated endogenous GNE-encoding sequence. In other words, the present invention includes providing, for example, a cell or muscular tissue that harbors a mutated (defective) GNE-encoding sequence with a functional wild-type GNE encoding sequence. | 02-03-2011 |
Patent application number | Description | Published |
20110053486 | MODULAR, SELF-CONTAINED, MOBILE CLEAN ROOM - Biosafety units, methods of making, and sealing the same are disclosed herein. The units comprise at least one controlled air, sealable, sterilizable cleanroom; and a mechanical system room adjacent to the cleanroom comprising: at least two air handling units in a support room adjacent the cleanroom that provide redundant air to the cleanroom with at least Class 100,000 air purity, the air handling units connected to a one or more supply ducts to the cleanroom, and an exhaust duct in communication with the cleanroom and the air handling unit exhaust, wherein a pressure gradient is formed between the cleanroom and the exterior of the structure; and at least two power supplies that provide redundant power to electrical outlets in the cleanroom, wherein the at least two power supplies are connectable to one or more external power sources and the structure is pre-validatable or validated for pharmaceutical manufacturing. | 03-03-2011 |
20110150832 | FURIN-KNOCKDOWN BI-FUNCTIONAL RNA - Compositions and methods to attenuate the immunosuppressive activity of TGF-β through the use of bi-functional shRNAs is described herein. The bi-functional shRNAs of the present invention knocks down the expression of furin in cancer cells to augment tumor antigen expression, presentation, and processing through expression of the GM-CSF transgene. | 06-23-2011 |
20110262408 | FURIN-KNOCKDOWN AND GM-CSF-AUGMENTED (FANG) CANCER VACCINE - Compositions and methods for cancer treatment are discloses herein. More specifically the present invention describes an autologous cancer vaccine genetically modified for Furin knockdown and GM-CSF expression. The vaccine described herein attenuates the immunosuppressive activity of TGF-β through the use of bi-functional shRNAs to knock down the expression of furin in cancer cells, and to augment tumor antigen expression, presentation, and processing through expression of the GM-CSF transgene. | 10-27-2011 |
20110286979 | CHEMOSENSITIZATION BY BI-FUNCTIONAL SMALL HAIRPIN RNA (bi-shRNA) - Compositions and methods of augmenting the anti-tumor activities of docetaxel and other taxanes by combination with a bi-functional small hairpin RNA (bi-shRNA) is described herein. The instant invention describes the interactive outcome of STMN1 knockdown with docetaxel. In vitro docetaxel (DOC) dose response assessments with or without co-treatment with bi-shRNA | 11-24-2011 |
20130078279 | FURIN-KNOCKDOWN AND GM-CSF-AUGMENTED (FANG) CANCER VACCINE - Compositions and methods for cancer treatment are discloses herein. More specifically the present invention describes an autologous cancer vaccine genetically modified for Furin knockdown and GM-CSF expression. The vaccine described herein attenuates the immunosuppressive activity of TGF-β through the use of bi-functional shRNAs to knock down the expression of furin in cancer cells, and to augment tumor antigen expression, presentation, and processing through expression of the GM-CSF transgene. | 03-28-2013 |
20130109291 | MODULAR, SELF-CONTAINED, MOBILE CLEAN ROOM | 05-02-2013 |
20140134236 | INDIVIDUALIZED CANCER THERAPY - In certain preferred embodiments, the invention provides methods for treating cancer, which comprise (a) obtaining a specimen of cancer tissue from a patient; (b) obtaining a specimen of normal tissue in the proximity of the cancer tissue from such patient; (c) extracting total protein and RNA from the cancer tissue and normal tissue; (d) obtaining a protein expression profile of the cancer tissue and normal tissue using 2D DIGE and mass spectrometry; (e) identifying proteins that are expressed in such cancer tissue at significantly different levels than in the normal tissue; (f) obtaining a gene expression profile of the cancer tissue and normal tissue using microarray technology and comparing the results thereof to the protein expression profile; (g) prioritizing over-expressed proteins by assessing the connectivity thereof to other cancer-related or stimulatory proteins; (h) designing an appropriate RNA interference expression cassette to, directly or indirectly, modulate the expression of genes encoding such prioritized proteins; (i) incorporating said cassette into an appropriate delivery vehicle; and (j) providing the patient with an effective amount of the delivery vehicle to, directly or indirectly, modify the expression (i.e., production) of such proteins. | 05-15-2014 |
20150086619 | INDIVIDUALIZED CANCER THERAPY - In certain embodiments, the invention provides methods for treating cancer, comprising: obtaining a specimen of cancer tissue and normal tissue from a patient; extracting total protein; obtaining a protein expression profile; identifying over-expressed proteins; comparing the protein expression profile to a gene expression profile; identifying at least one prioritized protein target; designing a first RNA interference expression cassette; designing a first RNA interference expression cassette to modulate the expression of at least one gene encoding; incorporating the first cassette into a delivery vehicle; and providing a patient with an effective amount of the first delivery vehicle. | 03-26-2015 |
20150329873 | FURIN-KNOCKDOWN AND GM-CSF-AUGMENTED (FANG) CANCER VACCINE - Compositions and methods for cancer treatment are disclosed herein. More specifically the present invention describes an autologous cancer vaccine genetically modified for Furin knockdown and GM-CSF expression. The vaccine described herein attenuates the immunosuppressive activity of TGF-β through the use of bi-functional shRNAs to knock down the expression of furin in cancer cells, and to augment tumor antigen expression, presentation, and processing through expression of the GM-CSF transgene. | 11-19-2015 |
20150368651 | FURIN-KNOCKDOWN BI-FUNCTIONAL RNA - Compositions and methods to attenuate the immunosuppressive activity of TGF-β through the use of bi-functional shRNAs is described herein. The bi-functional shRNAs of the present invention knocks down the expression of furin in cancer cells to augment tumor antigen expression, presentation, and processing through expression of the GM-CSF transgene. | 12-24-2015 |