Gennaro
Gennaro Amelio, Napoli IT
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20090125995 | Method and System For Accounting Access by Users to Data Networks, Related Computer Program Product - A system for the time-based accounting of access by users to services provided by a data network includes a primary access node to provide access by users by establishing via the primary access node a steady connectivity between the users and the network. A secondary access node is associated with the primary access node, such secondary access node being configured for acting as a backup node to maintain connectivity in the case of failure involving the primary access node. The primary access node is configured for issuing a request for credentials for any user requesting access to said data network and, as a result of receiving valid credentials from the user, starts time-based accounting for the user. An authentication node cooperative with the primary access node and the secondary access node stores the secondary access node information items concerning the time-based accounting started for the user. The time-based accounting is thus maintained in the case of failure involving the primary access node as connectivity is maintained by the secondary access node. | 05-14-2009 |
Gennaro Barbiero, Niskayuna, NY US
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20150112023 | IN-SITU ALKYLPHENOL-ALDEHYDE RESINS - The invention relates to an in-situ process for preparing an alkylphenol-aldehyde resin. The process comprises the step of providing a raw alkylphenol composition. The raw alkylphenol composition comprises one or more alkylphenol compounds and at least about 1 wt % phenol. Each alkylphenol compound has one or more alkyl substituents. The raw alkylphenol composition is reacted directly, without pre-purification, with one or more aldehydes to form an in-situ alkylphenol-aldehyde resin. The invention also relates to an in-situ alkylphenol-aldehyde resin formed from the in-situ process, and its use in a tackifier composition and rubber composition. The tackifier composition and rubber composition containing the in-situ alkylphenol-aldehyde resin show, inter alia, improved tack performance. | 04-23-2015 |
Gennaro Calabritto, Milanese-Milano IT
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20080202734 | Heat Exchanger - A heat exchanger for cooling a high temperature gas leaving a reaction unit/device, including a coupling element to the reaction unit/device, a gas transportation and cooling pipe, and a covering shell. | 08-28-2008 |
Gennaro Ciliberto, Rome IT
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20110182926 | MINIGENE - The present invention provides minigenes suitable as a prophylactic or therapeutic vaccine against conditions such as cancer, infectious diseases or autoimmune diseases, and pharmaceutical compositions comprising the minigene. The minigenes of the present invention comprise (a) a human tissue plasminogen signal peptide; (b) at least one T-cell epitope; and (c) an | 07-28-2011 |
20120177679 | MATRIX METALLOPROTEINASE 11 VACCINE - Compositions comprising matrix metalloproteinase 11 (MMP-11) or stromelysin-3 (ST-3) or the nucleic acid encoding the MMP-11 for use in vaccines for treating tumors and cancers, which overexpress MMP-11, are described. In particular embodiments, the compositions comprise a nucleic acid encoding a fusion polypeptide that includes the catalytically inactivated MMP-11 linked at the C-terminus to an immunoenhancing element wherein the codons encoding the MMP-11 and the immunoenhancing element have been optimized for enhanced expression of the fusion polypeptide in human cells. In other embodiments, the compositions comprise the catalytically inactivated MMP-11 linked at the C-terminus to an immunoenhancing element. The compositions can be used alone or in synergy with vaccines against other tumor associated antigens as well as with conventional therapies such as radiation therapy and chemotherapy. | 07-12-2012 |
20140017259 | IMMUNOTHERAPY AGAINST ERBB-3 RECEPTOR - The present invention describes methods and pharmaceutical compositions for the treatment of cancer in mammals, more particularly in human subjects. More specifically, the invention concerns anti-tumor vaccines based upon plasmid DNA and/or genetic vectors carrying a codon-usage optimized sequence and coding for a mutant form of the ErbB-3 receptor. Furthermore, the invention refers to monoclonal antibodies directed against the ErbB-3 receptor, obtained using these methods and capable to block its activity in cancer cells. | 01-16-2014 |
Gennaro Ciliberto, Roma IT
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20080311137 | Carcinoembryonic Antigen Fusions and Uses Thereof - Polynucleotides encoding carcinoembryonic antigen (CEA) fusion proteins are provided, the CEA fusion proteins comprising a CEA protein, or functional variant thereof, fused to a substantial portion of an immunoenhancing element. The polynucleotides of the present invention can elicit an immune response in a mammal, which, in preferred embodiments, is stronger than the immune response elicited by a wild-type CEA. The gene encoding CEA is commonly associated with the development of human carcinomas. The present invention provides compositions and methods to elicit or enhance immunity to the protein product expressed by the CEA tumor-associated antigen, wherein aberrant CEA expression is associated with a carcinoma or its development. This invention specifically provides adenoviral vector and plasmid constructs carrying polynucleotides encoding CEA fusion proteins and discloses their use in vaccines and pharmaceutical compositions for preventing and treating cancer. | 12-18-2008 |
20090155298 | Matrix Metalloproteinase 11 Vaccine - Compositions comprising matrix metalloproteinase 11 (MMP-11) or stromelysin-3 (ST-3) or the nucleic acid en->coding the MMP-11 for use in vaccines for treating tumors and cancers, which overexpress MMP-11, are described. In particular embodiments, the compositions comprise a nucleic acid encoding a fusion polypeptide that includes the catalytically inactivated MMP-11 linked at the C-terminus to an immunoenhancing element wherein the codons encoding the MMP-11 and the immunoenhancing element have been optimized for enhanced expression of the fusion polypeptide in human cells. In other embodiments, the compositions comprise the catalytically inactivated MMP-11 linked at the C-terminus to an immunoenhancing element. The compositions can be used alone or in synergy with vaccines against other tumor associated antigens as well as with conventional therapies such as radiation therapy and chemotherapy. | 06-18-2009 |
Gennaro Citro, Roma IT
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20090181418 | PEPTIDE ABLE TO BREAK THE M-P53/P63, M-P53/P73 AND M-P53/RESPECTIVE ISOFORM PROTEINS COMPLEX FORMED IN THE TUMOR CELLS AND USES THEREOF IN THE PHARMACOLOGICAL FIELD - The object of the present invention is the identification of a group of peptides able to break the interaction between the mutated protein p53 (hereinafter m-p53) and the proteins p63, p73 and the relative isoform proteins (hereinafter p63, p73 and p-isoforms) in the m-p53/p63, m-p53/p73 and m-p53/p-isoforms proteinic complex that has formed in the nucleus of tumor cells. Furthermore, the present invention relates to a method for causing the breakage of said proteinic complexes existing in the tumor cell lines in vitro. The present invention further relates to the use of said peptides for the preparation of a pharmaceutical composition for treating human tumors. | 07-16-2009 |
Gennaro Citro, Rome IT
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20080317771 | Anti-Clusterin Oligoclonal Antibodies for Diagnosis and Prediction of the Aggressiveness of Tumours, Diagnostic Method and Related Kits - The invention concerns anti-clusterin oligoclonal antibodies able to recognize and bind in a selective and specific way antigenic epitopes of clusterin isoforms to be used in tumours diagnosis and in the prediction of their malignancy grade, diagnostic method and related kits. | 12-25-2008 |
20120237614 | PEPTIDE ABLE TO DISRUPT THE PROTEIN COMPLEX BETWEEN THE HIS273 MUTADED P53 PROTEIN AND THE ONCOSUPPRESSIVE P73 PROTEIN IN TUMOR CELLS AND THERAPEUTIC USES THEREOF - The present invention concerns a SIMP peptide (Short-interfering mutant p53 peptides) suitable to disrupt the protein complexes within tumour cells resulting from m-p53 and p73 proteins selectively in tumours wherein m-p53 contains His273 mutation. | 09-20-2012 |
Gennaro De Libero, Immunos SG
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20150209308 | METHODS TO INHIBIT INTRACELLULAR GROWTH OF BACTERIA AND TO TREAT BACTERIA-MEDIATED DISEASES - Disclosed is a method of preventing, treating or inhibiting bacterial infections. The method comprises administering at least one of the compounds disclosed herein. Also disclosed are methods of increasing acidity of bacterial phagosomes to inhibit bacterial growth, methods of increasing mitochondrial reactive oxygen species (mROS) generation to inhibit bacterial growth in a cell, pharmaceutical compositions and uses thereof. | 07-30-2015 |
Gennaro De Libero, Bale CH
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20100166801 | SULFOGLYCOLIPID ANTIGENS, THEIR PROCESS OF PREPARATION, AND THEIR USE AGAINST TUBERCULOSIS - The present invention relates to compounds of the following general formula (I) their process of preparation and their use in the treatment or the prophylaxis of tuberculosis. | 07-01-2010 |
Gennaro De Libero, Bottmingen CH
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20100255015 | PHARMACEUTICALS COMPOSITIONS COMPRISING ACTINOMYCETE GLYCEROL ACYL DERIVATIVES ANTIGENS, THEIR PROCESS OF EXTRACTION, AND THEIR USE AGAINST TUBERCULOSIS - The present invention relates to the therapeutic use of actinomycete glycerol monomycolate derivatives as antigens, their process of extraction, and their use in the treatment or the prophylaxis of tuberculosis. | 10-07-2010 |
Gennaro De Michele, Pisa IT
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20130042857 | STORING AND TRANSPORT DEVICE AND SYSTEM WITH HIGH EFFICIENCY - A device for storage and conveyance of thermal energy for an energy production system apt to receive solar radiation and based on the use of a modular fluidizable granular bed and a heat exchanger associated thereto is described. | 02-21-2013 |
20130239950 | DEVICE, PLANT AND METHOD WITH HIGH LEVEL OF ENERGY EFFICIENCY FOR STORING AND USE OF THERMAL ENERGY OF SOLAR ORIGIN - A device for storing and releasing heat energy for an electrical power production plant is described. The device has: at least one bed of fluidisable particles, arranged at least partly at receiving surfaces for such radiation; means for feeding a fluidisation gas for the fluidisation of said particles; and heat exchange elements flown through, in use, by an operating fluid and arranged at or in proximity of said bed of fluidisable particles. | 09-19-2013 |
20150090251 | DEVICE, SYSTEM AND METHOD FOR HIGH LEVEL OF ENERGETIC EFFICIENCY FOR THE STORAGE AND USE OF THERMAL ENERGY OF SOLAR ORIGIN | 04-02-2015 |
Gennaro Melino, Rome IT
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20130071370 | INHIBITORS OF MICRO-RNAS FOR USE FOR PREVENTING AND/OR ATTENUATING SKIN AGEING AND/OR FOR HYDRATING SKIN - Method of identifying and using compounds which inhibit the expression or activity of micro-RNAs for preventing and/or attenuating ageing, and/or for hydrating skin. An in vitro method for screening for candidate compounds for preventing and/or attenuating ageing of the skin, and/or for hydrating the skin, includes the following steps: | 03-21-2013 |
Gennaro Melino, Leicester GB
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20090306187 | Modulators of Itch Ubiquitinase Activity - The present invention relates to the identification of new drug targets for therapy of disorders including cancer. In particular, the present invention relates to inhibition of the E3 ubiquitin ligase, Itch, as a means for treating disorders. Furthermore, the present invention relates to the regulation of p63 and p73 stability in cells. In particular, the invention relates to the modulation of the regulation of p63 and p73 stability in cells through modulation of the expression or activity of Itch. Moreover, the invention relates to the use of Itch as a target for the development of agents capable of modulating p63 or p73 stability and especially agents capable of modulating the interaction of Itch and p63 or p73. Such agents may be useful in therapeutic applications including cancer treatment and modulation of skin differentiation. | 12-10-2009 |
Gennaro Venoso, Pozzuoli IT
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20110178722 | Method and apparatus for detection of the remote origin fraction of radon present in a measuring site - A method and an apparatus for detecting the remote origin fraction of | 07-21-2011 |