Patent application number | Description | Published |
20140172040 | HEMODYNAMIC PERFORMANCE ENHANCEMENT THROUGH ASYMPTOMATIC DIAPHRAGM STIMULATION - An implantable system, and methodology, for improving a heart's hemodynamic performance featuring (a) bimodal electrodes placeable on the diaphragm, out of contact with the heart, possessing one mode for sensing cardiac electrical activity, and another for applying cardiac-cycle-synchronized, asymptomatic electrical stimulation to the diaphragm to trigger biphasic, diaphragmatic motion, (b) an accelerometer adjacent the electrodes for sensing both heart sounds, and stimulation-induced diaphragmatic motion, and (c) circuit structure, connected both to the electrodes and the accelerometer, operable, in predetermined timed relationships to the presences of valid V-events noted in one of sensed electrical and sensed mechanical, cardiac activity, to deliver diaphragmatic stimulation. The circuit structure includes accelerometer-linked computer structure for enabling selective review, for later operational modifications, of stimulation-produced diaphragmatic motions, and in a modified form, may additionally include timing-adjustment substructure capable of making adjustments in the mentioned timed relationships. | 06-19-2014 |
Patent application number | Description | Published |
20110106948 | Running Internet Applications with Low Rights - In various embodiments, applications that are configured to interact with the Internet in some way are executed in a restricted process with a reduced privilege level that can prohibit the application from accessing portions of an associated computing device. For example, in some embodiments, the restricted process can prohibit applications from read and write access to portions of a system's computer-readable media, such as the hard disk, that contains administrative data and settings information and user data and settings. In these embodiments, a special portion of the disk, termed a “containment zone”, is designated and used by applications in this restricted process. | 05-05-2011 |
20120102577 | INTEGRATING SECURITY PROTECTION TOOLS WITH COMPUTER DEVICE INTEGRITY AND PRIVACY POLICY - At computer device power on, the operating system of the computer device initiates a monitor. The monitor assigns a monitoring program to each program and object (collectively, “program”) running on the computer device to monitor the activities of the program. When the monitoring program is assigned to a program, the monitoring program is assigned an integrity and/or privacy label (collectively, “integrity label”) based on predetermined criteria applied to the monitored program. The monitoring program, in turn, assigns an integrity label to the program monitored by the monitoring program. The integrity label assigned to the monitored program is less than or equal to the integrity label of the monitoring program. The monitor enforces an integrity policy of the computer device based on the integrity label assigned to monitored programs and the integrity label associated with data, another program, or a remote network resource that the monitored program is seeking to access. | 04-26-2012 |
20130086678 | INTEGRATING SECURITY PROTECTION TOOLS WITH COMPUTER DEVICE INTEGRITY AND PRIVACY POLICY - At computer device power on, the operating system of the computer device initiates a monitor. The monitor assigns a monitoring program to each program and object (collectively, “program”) running on the computer device to monitor the activities of the program. When the monitoring program is assigned to a program, the monitoring program is assigned an integrity and/or privacy label (collectively, “integrity label”) based on predetermined criteria applied to the monitored program. The monitoring program, in turn, assigns an integrity label to the program monitored by the monitoring program. The integrity label assigned to the monitored program is less than or equal to the integrity label of the monitoring program. The monitor enforces an integrity policy of the computer device based on the integrity label assigned to monitored programs and the integrity label associated with data, another program, or a remote network resource that the monitored program is seeking to access. | 04-04-2013 |
Patent application number | Description | Published |
20100317045 | COMPOUNDS USED AS DYES COMPERABLE TO ALEXA FLUOR 350 DYES - Compounds used as dyes comperable to Alexa Fluor 350 dyes. The inventive compounds have high fluorescence quantum yield and high photostability. The dyes facilitate analysis of biological structures with enhanced sensitivity and selectivity. | 12-16-2010 |
20120156140 | FLUORESCENT COMPOUNDS - Compounds used as labels with properties comparable to known fluorescent compounds. The compounds can be conjugated to proteins and nucleic acids for biological imaging and analysis. Synthesis of the compounds, formation and use of the conjugated compounds, and specific non-limiting examples of each are provided. | 06-21-2012 |
20120294807 | FLUORESCENT COMPOUNDS - Compounds used as labels with properties comparable to known fluorescent compounds. The compounds can be conjugated to proteins and nucleic acids for biological imaging and analysis. Synthesis of the compounds, formation and use of the conjugated compounds, and specific non-limiting examples of each are provided. | 11-22-2012 |
20130045488 | BENZOCYANINE COMPOUNDS - Compounds useful as labels with properties comparable to known fluorescent compounds. The compounds are conjugated to proteins and nucleic acids for biological imaging and analysis. Synthesis of the compounds, formation and use of the conjugated compounds, and specific non-limiting examples of each are provided. | 02-21-2013 |
20130230465 | BENZOCYANINE COMPOUNDS - Compounds useful as labels with properties comparable to known fluorescent compounds. The compounds are conjugated to proteins and nucleic acids for biological imaging and analysis. Synthesis of the compounds, formation and use of the conjugated compounds, and specific non-limiting examples of each are provided. | 09-05-2013 |
20130230466 | CYANINE COMPOUNDS - Compounds used as labels with properties comparable to known fluorescent compounds. The compounds can be conjugated to proteins and nucleic acids for biological imaging and analysis. Synthesis of the compounds, formation and use of the conjugated compounds, and specific non-limiting examples of each are provided. | 09-05-2013 |
20130251637 | FLUORESCENT COMPOUNDS - Compounds used as labels with properties comparable to known fluorescent compounds. The compounds can be conjugated to proteins and nucleic acids for biological imaging and analysis. Synthesis of the compounds, formation and use of the conjugated compounds, and specific non-limiting examples of each are provided. | 09-26-2013 |
20140072515 | CYANINE COMPOUNDS - Compounds used as labels with properties comparable to known fluorescent compounds. The compounds can be conjugated to proteins and nucleic acids for biological imaging and analysis. Synthesis of the compounds, formation and use of the conjugated compounds, and specific non-limiting examples of each are provided. | 03-13-2014 |
20140255312 | CYANINE COMPOUNDS - Compounds used as labels with properties comparable to known fluorescent compounds. The compounds can be conjugated to proteins and nucleic acids for biological imaging and analysis. Synthesis of the compounds, formation and use of the conjugated compounds, and specific non-limiting examples of each are provided. | 09-11-2014 |
20150119281 | PHOSPHINE DERIVATIVES OF FLUORESCENT COMPOUNDS - A phosphine derivative of DyLight dyes modified with ethylene glycol or (poly)ethylene glycol groups. In one embodiment, the compounds are useful in chemoselective ligation reactions. | 04-30-2015 |
20150175591 | MARKER DYES FOR UV AND SHORT WAVE EXCITATION WITH HIGH STOKES SHIFT BASED ON BENZOXAZOLES - The invention concerns compounds based on benzoxazoles wherein selected substituents are each a reactive group A bound via a linker L and adapted to covalently bond a compound of the invention to a to-be-marked molecule K, wherein A is an amine, hydroxy or phosphoramidite function, a carboxylic acid, an alkyl or active ester derived therefrom; a carboxylic acid hydrazide; or a carboxylic acid amide where | 06-25-2015 |
Patent application number | Description | Published |
20100276470 | SURGICAL DEVICE - A surgical device includes a first jaw and a second jaw moveable relative to the first jaw between a first position, in which the first and second jaws are aligned within a plane, and a second position, in which the second jaw is in non-parallel correspondence to the plane. The surgical device may include a surgical member, e.g., a cutting and/or stapling element, disposed within the first jaw, and a second driver configured to cause relative movement of the surgical member in a direction parallel to the plane. The first and second jaws may include a camming arrangement that is configured to move the second jaw between the first and second positions. The camming arrangement may include a channel disposed along at least a portion of one or both of the first and second jaws, a ball bearing disposed within the channel. | 11-04-2010 |
20120136380 | SURGICAL DEVICE - A surgical device includes a first jaw and a second jaw moveable relative to the first jaw between a first position, in which the first and second jaws are aligned within a plane, and a second position, in which the second jaw is in non-parallel correspondence to the plane. The surgical device may include a surgical member, e.g., a cutting and/or stapling element, disposed within the first jaw, and a second driver configured to cause relative movement of the surgical member in a direction parallel to the plane. The first and second jaws may include a camming arrangement that is configured to move the second jaw between the first and second positions. The camming arrangement may include a channel disposed along at least a portion of one or both of the first and second jaws, a ball bearing disposed within the channel. | 05-31-2012 |
20120273546 | SURGICAL DEVICE - A surgical device is provided that includes a jaw portion with a first jaw and a second jaw moveable relative to the first jaw. The surgical device also includes a shaft portion coupled to a proximal end of the jaw portion. A driver is configured to cause relative movement of the jaw portion and the shaft portion. The driver may be configured to cause the jaw portion to pivot relative to the shaft portion about a pivot axis that is perpendicular to first and second longitudinal axes defined by the jaw portion and the shaft portion, respectively. The driver may also be configured to cause at least a portion of the jaw portion to rotate relative to the shaft portion about the first longitudinal axis. Advantageously, the surgical device includes a surgical member, e.g., a cutting element and/or a stapling element, disposed within the first jaw. | 11-01-2012 |
20140131416 | SURGICAL DEVICE - A surgical device is provided that includes a jaw portion with a first jaw and a second jaw moveable relative to the first jaw. The surgical device also includes a shaft portion coupled to a proximal end of the jaw portion. A driver is configured to cause relative movement of the jaw portion and the shaft portion. The driver may be configured to cause the jaw portion to pivot relative to the shaft portion about a pivot axis that is perpendicular to first and second longitudinal axes defined by the jaw portion and the shaft portion, respectively. The driver may also be configured to cause at least a portion of the jaw portion to rotate relative to the shaft portion about the first longitudinal axis. Advantageously, the surgical device includes a surgical member, e.g., a cutting element and/or a stapling element, disposed within the first jaw. | 05-15-2014 |
Patent application number | Description | Published |
20120138512 | Sorting apparatus and method utilizing a mechanical diverter - The present invention is an apparatus and method for sorting foreign material and undesirable articles from a product stream. A mechanical diverter having a concave shape is responsive to an inspection station coupled to the product stream. The mechanical diverter is employed to effectively launch or otherwise redirect undesirable articles in an alternate path. In addition, an air ejector in one form of the invention is provided and is responsive to the inspection station and is employed to dislodge foreign material from the product stream. | 06-07-2012 |
20130126396 | Sorting apparatus - A sorting apparatus is described, and which includes a conveyor which transports a produce stream for inspection. A product separation surface is mounted near the distal end of the conveyor, and the produce stream passes over the product separation surface, and is slowed to a speed such that the produce stream falls substantially immediately vertically downwardly. An inspection zone is located downstream relative to the product separation surface. An imaging device is provided, and which images the produce stream passing through the inspection zone; an illumination device is provided for illuminating the produce stream passing through the inspection zone, and an ejector assembly is located downstream of the inspection zone and which removes unwanted solid material in the produce stream having undesirable characteristics. | 05-23-2013 |
20130277284 | Sorting Apparatus - A sorting apparatus is described, and which includes a conveyor which transports a produce stream for inspection. The conveyor has various regions formed in part of ridges, troughs and apertures which reduce the weight of the produce stream, as well as reduces the vertical and horizontal components of motion of the produce stream, as the produce stream progresses from one end to the other. | 10-24-2013 |
Patent application number | Description | Published |
20100021596 | APPARATUS AND PROCESS FOR PREPARING CONFECTIONERY HAVING AN INCLUSION THEREIN USING FORMING ROLLS AND A FORMING PIN - The present invention is directed to a forming apparatus comprising (a) first and second forming rolls with forming pockets in corresponding alignment, wherein at least one roll has one or more continuous grooves extending around the circumference of the roll in a plane perpendicular to the longitudinal axis of the roll and which intersects the forming pockets in the plane, wherein the first and second forming rolls rotate in directions counter to one another, and (b) one or more forming pins positioned between the counter rotating rolls and within the continuous groove of the roll. | 01-28-2010 |
20120114804 | APPARATUS AND PROCESS FOR PREPARING CONFECTIONERY HAVING AN INCLUSION THEREIN USING FORMING ROLLS AND A FORMING PIN - The present invention is directed to a forming apparatus comprising (a) first and second forming rolls with forming pockets in corresponding alignment, wherein at least one roll has one or more continuous grooves extending around the circumference of the roll in a plane perpendicular to the longitudinal axis of the roll and which intersects the forming pockets in the plane, wherein the first and second forming rolls rotate in directions counter to one another, and (b) one or more forming pins positioned between the counter rotating rolls and within the continuous groove of the roll. | 05-10-2012 |
20150272159 | APPARATUS AND PROCESS FOR PREPARING CONFECTIONERY HAVING AN INCLUSION THEREIN USING FORMING ROLLS AND A FORMING PIN - The present invention is directed to a forming apparatus comprising (a) first and second forming rolls with forming pockets in corresponding alignment, wherein at least one roll has one or more continuous grooves extending around the circumference of the roll in a plane perpendicular to the longitudinal axis of the roll and which intersects the forming pockets in the plane, wherein the first and second forming rolls rotate in directions counter to one another, and (b) one or more forming pins positioned between the counter rotating rolls and within the continuous groove of the roll. | 10-01-2015 |
Patent application number | Description | Published |
20090253655 | QUINOLINONE FARNESYL TRANSFERASE INHIBITORS FOR THE TREATMENT OF SYNUCLEINOPATHIES AND OTHER INDICATIONS - Novel quinolinone farnesyl transferase inhibitors are provided. These new compounds are useful in the treatment or prevention of synucleinopathies, such as Parkinson's Disease, Diffuse Lewy Body Disease, multiple system atrophy, and disorders of brain iron concentration including pantothenate kinase-associated neurodegeneration (e.g., PANK1), or other neurodegenerative/neurological diseases. Provided compounds are also useful in the treatment of proliferative diseases such as cancer, and in the treatment of neurological diseases, such as cognitive impairment, depression, and anxiety. | 10-08-2009 |
20100160372 | TREATMENT OF PROTEINOPATHIES USING A FARNESYL TRANSFERASE INHIBITOR - Methods and pharmaceutical compositions comprising a low dose of a farnesyl transferase inhibitor useful in the treatment of proteinopathies are provided. These low doses are below the doses used in oncological treatments for which these compounds were initially designed. The treatment includes administering to a subject in need thereof a therapeutically effective amount of a farnesyl transferase inhibitor, wherein the amount is effective to inhibit the farnesylation of a non-Ras FTase substrate involved in the autophagy pathway without substantially affecting the farnesylation of Ras or other oncology related substrates. Treatments in accordance with the present invention may also include an acetylcholinesterase inhibitor, an activator of neurotrophic receptors, an NMDA antagonist, an amyloid deposit inhibitor, an antipsychotic agent, an antidepressant, an anxiolytic, or an antioxidant. | 06-24-2010 |
20100184803 | Treatment of Lysosomal Storage Diseases - Methods and compositions useful in the treatment or prevention of lysosomal storage diseases, such as Pompe's disease, Fabry's disease, Gaucher's disease, and Niemann-Pick disease, are provided. The treatment includes administering to a subject a farnesyl transferase inhibitor compound. The treatment may also include enzyme replacement therapy or gene therapy. | 07-22-2010 |
20100292292 | Treatment of Neurodegenerative Diseases Using Indatraline Analogs - Methods and compositions useful in the treatment or prevention of synucleinopathies, such as Parkinson's disease, diffuse Lewy body disease, and multiple system atrophy, or other neurodegenerative diseases (e.g., amyotrophic lateral sclerosis, Huntington's disease, and Alzheimer's disease) are provided. The treatment including administering to a subject an indatraline derivative that inhibits the aggregation of α-synuclein. | 11-18-2010 |
20100331363 | TREATMENT OF MITOCHONDRIAL DISORDERS USING A FARNESYL TRANSFERASE INHIBITOR - Methods and pharmaceutical compositions comprising a low dose of a farnesyl transferase inhibitor useful in the treatment of proteinopathies are provided. These low doses are below the doses used in oncological treatments for which these compounds were initially designed. The treatment includes administering to a subject an amount of a farnesyl transferase inhibitor, wherein the amount administered is sufficient to cause an improvement in mitochondrial health in said subject. Treatments in accordance with the present invention may also include an acetylcholinesterase inhibitor, an activator of neurotrophic receptors, an NMDA anatagonist, an amyloid deposit inhibitor, an antipsychotic agent, an antidepressant, an anxiolytic, or an antioxidant. | 12-30-2010 |
20110060005 | TREATMENT OF MITOCHONDRIAL DISORDERS USING A FARNESYL TRANSFERASE INHIBITOR - Methods and pharmaceutical compositions comprising a low dose of a farnesyl transferase inhibitor useful in the treatment of proteinopathies and mitochondrial disorders are provided. These low doses are below the doses used in oncological treatments for which these compounds were initially designed. The treatment includes administering to a subject an amount of a farnesyl transferase inhibitor, wherein the amount administered is sufficient to stimulate mitophagy in said subject. Treatments in accordance with the present invention may also include an acetylcholinesterase inhibitor, an activator of neurotrophic receptors, an NMDA anatagonist, an amyloid deposit inhibitor, an antipsychotic agent, an antidepressant, an anxiolytic, or an antioxidant. | 03-10-2011 |
20110136867 | Treatment of Synucleinopathies - Methods and compositions useful in the treatment or prevention of synucleinopathies, such as Parkinson's Disease, Diffuse Lewy Body Disease, and Multiple System Atrophy, or other neurodegenerative diseases are provided. The treatment including administering to a subject a farnesyl transferase inhibitor compound. | 06-09-2011 |
20110294794 | TREATMENT OF PROTEINOPATHIES USING A FARNESYL TRANSFERASE INHIBITOR - Methods and pharmaceutical compositions comprising a low dose of a farnesyl transferase inhibitor useful in the treatment of proteinopathies are provided. These low doses are below the doses used in oncological treatments for which these compounds were initially designed. The treatment includes administering to a subject in need thereof a therapeutically effective amount of a farnesyl transferase inhibitor, wherein the amount is effective to inhibit the farnesylation of a non-Ras FTase substrate involved in the autophagy pathway without substantially affecting the farnesylation of Ras or other oncology related substrates. Treatments in accordance with the present invention may also include an acetylcholinesterase inhibitor, an activator of neurotrophic receptors, an NMDA anatagonist, an amyloid deposit inhibitor, an antipsychotic agent, an antidepressant, an anxiolytic, or an antioxidant. | 12-01-2011 |
Patent application number | Description | Published |
20100051168 | APPARATUS AND A METHOD FOR CURING A LINER OF A PIPELINE - The present invention relates to an apparatus for curing a liner of a pipeline where the liner includes a resin which is curable by exposure to electromagnetic radiation of a specific wavelength or a specific wavelength range. The apparatus comprises a housing defining opposite first and second ends, an outer wall of a substantially cylindrical configuration, and an inner wall defining a substantially unobstructed through-going passage extending longitudinally through the housing between the first and second ends, and further comprises a pair of power supply wires for the supply of electrical power to the apparatus and extending from the first end of the housing, and a plurality of LED's irradiating electromagnetic radiation of the specific wavelength or the specific wavelength range. The plurality of LED's is positioned and substantially evenly distributed at the outer wall of the housing, and is connected through an electronic circuit to the pair of power supply wires. The plurality of LED's is further connected in thermal conductive relationship to heat dissipating elements freely exposed at the inner wall of the housing in the through-going passage of the housing for allowing a stream of cooling fluid to pass through the passage for dissipating heat from the heat dissipating elements and cooling the LED's. | 03-04-2010 |
20140044426 | APPARATUS AND A METHOD FOR CURING A LINER OF A PIPELINE - A system for curing a pipeline liner that includes a resin curable by exposure to radiation includes first and second liner curing apparatuses, each of which includes a housing defining opposite first and second ends, and outer and inner walls defining a passage between the first and second ends; a plurality of LED's on the outer wall and operable to irradiate the radiation; and a plurality of heat dissipating elements on the inner wall. The LED's are connected in thermally-conductive relationship to the heat dissipating elements, whereby heat is dissipated from the heat dissipating elements to cool the LED's when a stream of cooling fluid passes through the passage. In use, the apparatuses, joined end-to-end, are moved within the liner while irradiating radiation from the LED's onto the liner, and the velocity of the apparatuses moving through the liner is adjusted to cause a complete curing of the resin. | 02-13-2014 |
Patent application number | Description | Published |
20130038112 | NON-NEWTONIAN STRESS THICKENING FLUID VIBRATION DAMPER SYSTEM FOR VEHICLE SEAT - A vibration damper for a vehicle seat back is disclosed. The vibration damper includes an enclosure provided inside the upper end of a vehicle seat back. The enclosure includes a plurality of projections, preferably in the form of spaced apart, vertically extending pins, extending from one or more interior walls of the enclosure. A non-newtonian stress thickening fluid is provided within the enclosure. When the seat back is at rest the stress thickening fluid is free flowing within the enclosure. When the seat back is moved the stress thickening fluid is acted upon by the walls of the enclosure, the internally mounted pins, or both. As the walls and pins push on the fluid it comes under shear stress which causes the fluid to harden. As the pin passes through the hardened fluid they absorb energy and dampen the motion. | 02-14-2013 |
20150070195 | METHOD AND SYSTEM TO REDUCE BRAKING FOR STOP LIGHTS - A vehicle includes a powertrain, a brake, and a controller configured to anticipate an impending stoplight change, predict a status of a stoplight that will occur when the vehicle arrives at the stoplight, and display the prediction. | 03-12-2015 |
20150084360 | COLLAPSIBLE REAR SEAT STORAGE ASSEMBLY - An underseat storage assembly for a vehicle seat includes a recess disposed on a floor below the vehicle seat. A front panel has an edge pivotally coupled with the floor and first and second side panels are pivotally coupled with opposing ends of the front panel. The front panel is movable between a stored position within the recess and a deployed position and has the first and second side panels vertically arranged and orthogonal to the front panel. | 03-26-2015 |