Angel
Angel Albir Blasco, Alicante ES
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20090149785 | Massage device - The invention relates to a massage device which is intended for a massage chair, consisting of a support for an eccentric rotating shaft ( | 06-11-2009 |
Angel Argilés, Madrid ES
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20110110476 | Cover Device for Jet Pumps Installed in Nuclear Power Plant Vessels - The invention relates to a plug device for jet pumps installed in nuclear power plant vessels, which comprises two covers ( | 05-12-2011 |
Angel Argilés, Madrid ES
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20110110476 | Cover Device for Jet Pumps Installed in Nuclear Power Plant Vessels - The invention relates to a plug device for jet pumps installed in nuclear power plant vessels, which comprises two covers ( | 05-12-2011 |
Angel Argiles Ciscart, Saint Gely Du Fesc FR
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20110240555 | APPARATUS FOR EXTRACORPOREAL BLOOD TREATMENT AND METHOD FOR MANAGING SUCH AN APPARATUS - A method for controlling an apparatus for treating blood outside the human body, with a view to improving the operation of the apparatus, the apparatus including a semi-permeable membrane carrying out an exchange of solutes, referred to as dialysis, and of liquid, referred to as ultrafiltration, with the blood, the method including at least one iteration of the following steps: determination of a so-called instantaneous value, of an ultrafiltration coefficient corresponding to the ratio of an ultrafiltration flow rate to a difference in pressure, the so-called transmembrane pressure, on either side of the semi-permeable membrane, comparison of the instantaneous value with at least one previously determined characteristic value; and control of the treatment apparatus to reach a maximum value of the ultrafiltration coefficient, the control including a variation of the ultrafiltration flow rate up to a value corresponding to the maximum value of the ultrafiltration coefficient. | 10-06-2011 |
Angel Atance Orden, Montcada I Reixac ES
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20100092711 | MOLD AND METHOD FOR MANUFACTURING TWO-LAYERED PREFORMS BY INJECTION OVERMOLDING, AND TWO-LAYERED PREFORM - The mold includes a first molding cavity connected to a first hot channel for supplying a primary molding material, a second overmolding cavity connected to a second hot channel for supplying an overmolding material; and a core configured to be first introduced in the first cavity for a molding operation of a first layer, and to then be introduced, with the first layer thereon, in the second cavity for an overmolding operation of a second layer. At least one supporting member is arranged to support the core with respect to the first cavity during the entire molding operation of the first layer. An opening left in the first layer by the supporting member is filled and/or covered by the second layer. | 04-15-2010 |
20120328814 | TWO-LAYERED PREFORM OBTAINED BY INJECTION OVERMOLDING - The two-layered preform includes a tubular body having a mouth providing a neck at a first end thereof and a closed bottom at an opposite second end. At least part of the tubular body is formed by a first layer (P | 12-27-2012 |
Angel Ayuso Sacido, Valencia ES
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20120078136 | DEVICE FOR COLLECTING SEMEN SAMPLES - The invention relates to a device for collecting semen samples, which is configured such that the patient/donor can perform ejaculation and the corresponding semen collection in his own home, for subsequent transfer to a medical centre or laboratory where the semen can be analyzed. The invention is characterized in that it consists of a preferably plastic cylindrical tube including mouth that is provided with a peripheral flange having a rounded edge in order to allow the condom into which the patient/donor ejaculates to be securely fastened thereto, and a closure cover that is screwed onto the cylindrical tube in order to press and secure the semen-filled condom housed inside said tube. | 03-29-2012 |
Angel Bercedo Miro, Madrid ES
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20120036648 | PROCESS FOR PRODUCING FIREPROOF VISCOSE - The flame retardant viscose is obtained by adding silica to the viscose and subsequently fixing the silica to the fibre, such that the final flame retardant fibre will have regenerated cellulose and a silica polymer providing the fibres with flame retardant properties. Conventionally, the regeneration of the viscose mixture is carried out using zinc sulphate, while the final phase of washing of the fibre is accomplished using sulphuric acid. Both zinc and sulphuric acid are highly contaminating products from the environmental point of view. The invention consists, on the one hand, of replacing the zinc sulphate with aluminium sulphate and, on the other, of replacing the sulphuric acid with hydrogen peroxide or oxygenated water, this minimising the contaminating effect of the process to an extraordinary extent. | 02-16-2012 |
Angel Cabria, Madrid ES
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20100163495 | System and method for filtration of liquids - The present invention relates to a system and a process of running the system that allows for the long term filtration of product without loss of filtration capability due to clogging or fouling. The system is a normal flow filtration system having one or more filter cartridges attached to an outlet of a housing in the system. The filter cartridge(s) are contained within a bowl and depend preferably vertically from the outlet. Liquid enters the bowl of the housing and contacts the outer surfaces of the one or more cartridges. Impurities are trapped on or in the surface of the filter and the filtered liquid flows through the filter and through the outlet. One or more parameters such as flow rate, transmembrane pressure drop and/or time are measured and when the desired parameter(s) are met, the filtration ceases. A backflushing occurs back through the filter cartridges so as to remove the trapped impurities on or in the filter surface. This backwashed material is directed to an outlet of the bowl that is connected to a drain. Additionally a port formed in the side of the housing adjacent an outer surface of the cartridge(s) can be used to provide a lateral washing of the filter surfaces. The system is then recirculated in a downstream manner to reestablish equilibrium and filtration is the restarted. | 07-01-2010 |
20140091019 | SYSTEM AND METHOD FOR FILTRATION OF LIQUIDS - A normal flow filtration system having a housing with one or more filters contained within a bowl and attached to the outlet of the system. Liquid enters the bowl, contacts the surfaces of the one or more filters. Impurities are trapped in the filter and the filtered liquid flows through to the outlet. Parameter(s) such as flow rate, transmembrane pressure drop and/or time are measured and when met, filtration ceases. A backflushing occurs through the filter(s) so as to remove the impurities from the filter. This backwashed material is directed to an outlet of the bowl that is connected to a drain. Additionally a port formed in the side of the housing adjacent an outer surface of the filter(s) can be used to provide a lateral washing of the filter(s). The system is then recirculated in a downstream manner to reestablish equilibrium and filtration is then restarted. | 04-03-2014 |
Angel Calvete Zumalde, Zamudio (vizcaya) ES
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20090265973 | QUICK-ASSEMBLY BREECH PLUG FOR MUZZLELOADER FIREARMS - The invention relates to a quick-assembly breech plug for muzzleloader firearms, allowing a quick assembly and disassembly and being extremely practical, simple to manufacture and having a low cost, wherein said breech plug comprises a cylindrical body ( | 10-29-2009 |
Angel Caudevilla De Sola, Zaragoza ES
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20110006649 | COVER FOR AN INSPECTION GLASS OF A WASHER AND/OR DRYER DOOR, WASHER AND/OR DRYER DOOR COMPRISING A COVER FOR AN INSPECTION GLASS, AND WASHER AND/OR DRYER COMPRISING A DOOR THAT HAS A COVER FOR AN INSPECTION GLASS - A door of a washer and/or a dryer, the door including a frame to hinge the door to a machine housing of the washer and/or dryer, an inspection glass, and a cover for the inspection glass, wherein the cover has two essentially opposite main sides and an outer circumferential zone. Smooth conical surfaces of the cover and of the frame are in contact with one another to hold the cover in the frame, and the circumferential zone tapers in an area of a contact surface towards the frame. | 01-13-2011 |
Angel Cebolla Ramirez, Sevilla ES
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20080280355 | Control of Gene Expression with the Use of a Transcription Attenuator - This invention relates to a system for the expression of heterologous genes, comprising an attenuator element which inhibits the elongation of the transcription of the heterologous genes, the expression of which is to be controlled, and two regulating modules which control the expression of the attenuator element. The invention also relates to the use of said expression system for the amplification of the expression of recombinant proteins, RNAs or apolipoproteins in bacteria. The invention further relates to vectors containing said expression system. | 11-13-2008 |
20090214655 | Method and Device for Obtaining Micro and Nanometric Size Particles - The invention relates to a method and device for obtaining micro and nanometric particles in a controlled, reproducible manner. The aforementioned particles have a spherical shape and a very narrow, uniform size distribution. More specifically, the invention relates to a novel method of forming emulsions and to the application thereof in micro and nanoencapsulation techniques involving the extraction/evaporation of the solvent. In particular, the invention relates to the encapsulation of the fluorescent compounds and the subsequent application thereof. | 08-27-2009 |
20090215154 | Method of preparing micro-and nanometric particles with labile Products - The invention relates to a method of obtaining micro- and nanometric polymeric particles in a controlled, reproducible manner. The aforementioned particles have a spherical shape and a very narrow, uniform size distribution. The invention comprises the use of an easy particle-forming method consisting in using hydrodynamic forces to focus a composite microjet formed by two concentric fluids and can be used in the encapsulation of fragile compounds of biological interest, from peptides and proteins to cells and micro-organisms. | 08-27-2009 |
Angel Cebolla Ramirez, Sevilla JP
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20100234567 | METHODS FOR SEPARATING RECOMBINANT PROTEINS IN AQUEOUS TWO-PHASE SYSTEMS - The object of the present invention is a procedure for the distribution, separation and purification in aqueous solution of recombinant proteins, based on the utilization of polypeptides with choline affinity. The invention is based on a phenomenon consisting of that two aqueous solutions with determinated components can be mixed, being distributed finally in two phases with different density. The fusionated proteins to said polypeptides with choline affinity are preferably located in one of the phases, while most of the cell extract proteins tend to go to the opposite phase. After a series of washings for removing the rest of the not desired material, this location can be inverted through the addition of a soluble molecule with affinity by the polypeptide fusionated to the protein of interest. This procedure allows modulating at convenience the presence of the protein or polypeptide of interest in one phase or another, possibiliting its purification with a high yield and purity grade. The invention represents an economic and scalable way of recombinant protein separation labelled preferably with choline-binding domains. | 09-16-2010 |
Angel Cid-Arregui, Heidelberg DE
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20110052496 | HOLLOW NANOPARTICLES AND USES THEREOF - Aspects of the invention provide hollow nanoparticles and uses thereof. In particular, the invention provides membrane-enclosed vesicles comprising a truncated form of an HBsAg S protein lacking one or two of its amino-terminal transmembrane domains. | 03-03-2011 |
Angel Concheiro Nine, Santiago De Compostela ES
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20090214604 | Method of obtaining hydrogels of cyclodextrins with glycidyl ethers, compositions thus obtained and applications thereof - The invention relates to a method of obtaining hydrogels based on (i) cyclodextrins, (ii) cyclodextrins and cellulose ethers or (iii) cyclodextrins and guar gum or the derivatives of same, using molecules containing two or more glycidyl ether groups in the structure thereof as a cross-linking agent. The invention also relates to the compositions thus obtained, which can include active substances and pharmaceuticals and which form inclusion complexes with cyclodextrins. The invention further relates to the use of same as components of controlled-release devices, such as transdermal pharmaceutical forms, vaginal, otic, ocular, rectal, oral or buccal transmucosal forms and parenteral implants, which are designed to administer active substances or pharmaceuticals to humans, animals or plants, or as components of cosmetic formulations. In addition, the invention relates to the use of said compositions as chelating agents in the extraction of biological or toxic molecules from living organisms or contaminating substances from water. | 08-27-2009 |
20110200661 | ACRYLIC HYDROGELS WITH PENDANT CYCLODEXTRINS, PREPARATION METHOD THEREOF AND USE OF SAME AS RELEASE SYSTEMS AND CONTACT LENS COMPONENTS - The invention relates to acrylic hydrogels with pendant cyclodextrins, the preparation and application thereof as release systems and components of contact lenses. The method for obtaining acrylic hydrogels with pendant cyclodextrins is characterized in that the hydrogels are formed by a polymer lattice obtained by polymerization of mono- and bifunctional acrylic or methacrylic monomers and monomers having glycidyl groups in their structure, to which cyclodextrin units are covalently bound once formed; and the use and applications of the compositions in the preparation of contact lenses with the capacity for incorporating drugs, active substances or demulcents useful in the treatment of pathological or physiological conditions, in the production of topical, transdermal or transmucosal release systems for medicinal products or active substances, and in the preparation of cosmetics. | 08-18-2011 |
20130156724 | USE OF POLOXAMINESINES AS INDUCERS OF THE OSTEOGENIC DIFFERENTIATION OF MESENCHYMAL CELLS - The invention describes for first time the activity of poloxamines as inducers in the differentiation of mesenchymal or progenitor cells. In particular, the invention demonstrates that poloxamines have an osteogenic ability. The invention relates to the use of one or more poloxamines or a pharmaceutical composition comprising same for the preparation of a drug for treting patients with bone defects in general. The invention also relates to a method for inducing the differentiation of mesenchymal or progenitor cells into osteoblasts by bringing said cells into contact with a sterilised aqueous dispersion or solution of one or more poloxamines. | 06-20-2013 |
Angel Decegama, Westford, MA US
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20100054701 | REAL-TIME SOFTWARE VIDEO/AUDIO TRANSMISSION AND DISPLAY WITH CONTENT PROTECTION AGAINST CAMCORDER PIRACY - The invention presents new methods of compression, transmission, and decompression of video signals providing increased speed and image quality and for protecting against camcorder piracy. Methods based on selecting an anchor frame, wavelet transformation with decimation and time stamping can provide one-pass encoding of signals in which the amount of bits of information needed to be transmitted can be substantially reduced, thereby increasing the speed of transmission of digital signals over networks. Decompressing signals, along with interpolation methods to re-create portions of images of lesser importance in visual perception, can provide coordinated video and audio presentations of high quality in real-time over all kinds of networks and frame interpolation resulting in a displayed frame rate significantly higher than 30 fps. The use of randomly selected anchor frames can render reconstructed transmitted images of poor quality for pirates who do not have access to identities of anchor frames. | 03-04-2010 |
20100172419 | Systems and methods for compression, transmission and decompression of video codecs - Embodiments of this invention include mathematical methods to develop software and/or hardware implementations that use wavelet transforms (WT) to pre-process video frames that can then be compressed using a variety of codecs to produce compressed video frames. Such compressed video frames can then be transmitted, decompressed, post-processed using the post-processing methods disclosed in the invention and displayed in their original size and quality using software and/or hardware implementations of embodiments of the invention, thereby producing real-time high-quality reproduction of video sequences. Embodiments include computer devices and computer readable media to implement these methods. | 07-08-2010 |
20100329352 | Systems and methods for compression, transmission and decompression of video codecs - Embodiments of this invention include computer-implemented mathematical methods to develop software and/or hardware implementations that use wavelet transforms (WT) to pre-process video frames that can then be compressed using a variety of codecs to produce compressed video frames. Such compressed video frames can then be transmitted, decompressed, post-processed using the post-processing methods disclosed in the invention and displayed in their original size and quality using software and/or hardware implementations of embodiments of the invention, thereby producing real-time high-quality reproduction of video sequences. Embodiments include computer devices and computer readable media to implement these methods. | 12-30-2010 |
20120121022 | SYSTEMS AND METHODS FOR COMPRESSION, TRANSMISSION AND DECOMPRESSION OF VIDEO CODECS - Embodiments of this invention include computer-implemented mathematical methods to develop software and/or hardware implementations that use wavelet transforms (WT) to pre-process video frames that can then be compressed using a variety of codecs to produce compressed video frames. Such compressed video frames can then be transmitted, decompressed, post-processed using the post-processing methods disclosed in the invention and displayed in their original size and quality using software and/or hardware implementations of embodiments of the invention, thereby producing real-time high-quality reproduction of video sequences. Embodiments of devices that can implement the methods of this invention include mainframe computers, desktop computers, personal computers, laptop computers, tablet computers, wireless computers, television sets, set top boxes, cellular telephones, and computer readable media. | 05-17-2012 |
20130315317 | Systems and Methods for Compression Transmission and Decompression of Video Codecs - Embodiments of this invention include computer-implemented mathematical methods to develop software and/or hardware implementations that use wavelet transforms (WT) to pre-process video frames that can then be compressed using a variety of codecs to produce compressed video frames. Such compressed video frames can then be transmitted, decompressed, post-processed using the post-processing methods disclosed in the invention and displayed in their original size and quality using software and/or hardware implementations of embodiments of the invention, thereby producing real-time high-quality reproduction of video sequences. Embodiments of devices that can implement the methods of this invention include mainframe computers, desktop computers, personal computers, laptop computers, tablet computers, wireless computers, television sets, set top boxes, cellular telephones, and computer readable media. | 11-28-2013 |
Angel De Lera, Vigo ES
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20100120885 | Novel Derivatives of Psammaplin A, A Method For Their Synthesis And Their Uses For The Prevention Or Treatment Of Cancer - Derivatives of psammaplin A responding to formula (I), a method for their synthesis and their use for the preparation of a medicament for preventing and for treating a tumor or a cancer. Formula (I). | 05-13-2010 |
Angel Diaz Carmena, Algete (madrid) ES
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20120057679 | DISCHARGE MODULE FOR HIGH VOLTAGE X-RAY TUBES - Discharge module which is formed by three circuits, a control and measurement circuit for X-rays, a voltage division circuit between serial switches, which is independent from the previous one, and a third circuit of the charge short circuit, which in turn is formed by a successive or slave trip circuit of the switches and another main discharge circuit through the switches; due to the established configuration, a much improved radiation control is achieved as it is not affected by unforeseen agents, the short circuit current is not restricted to the port current of the switches, and residual voltage of the switches is reduced. | 03-08-2012 |
20130142311 | METHOD FOR THE AUTOMATIC CONTROL OF MAXIMUM POWER FOR X-RAY APPARATUSES, AND DEVICE REQUIRED FOR SAME - A method of operating an x-ray unit that supplies the maximum power at all times, for which the supply or input voltage at the x-ray tube must be half the power supply voltage ((Vbat)/2 or (Vline)/2), which will be termed the reference voltage (Vref). In case of a deviation from the reference voltage, the method modifies the current supplied, changing the exposure time so that the maximum power is delivered at all times. In short, it is based on a method that regulates the tube current as a function of the supply voltage (of the batteries or the grid). | 06-06-2013 |
Angel Diaz, Jr., Pinecrest, FL US
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20090067624 | System and method of protecting content of an electronic file using a computer - A system and method of protecting the content of an electronic file using at least one computer. The invention includes providing at least one local key file having unique local encryption key data. In addition, the method includes selecting a random portion of the local encryption key data, and selecting a portion from the electronic file. The method further includes encrypting the portion of the electronic file by utilizing the portion of the local encryption key and at least one encryption formula or algorithm. | 03-12-2009 |
20090070580 | Portable electronic file protection system - The portable electronic file protection system includes at least one memory device removably disposed in communicative relation with any one of a plurality of computers. The memory device includes computer readable content contained thereon wherein the content includes electronic file protection software and at least one set of encryption key data. Further, the said electronic file protection software is executable while the memory device is disposed in communicative relation with any one of said plurality of computers. | 03-12-2009 |
20090077377 | System and method of protecting content of an electronic file for sending and receiving - A system and method of protecting the content of an electronic file for sending and receiving. The invention includes providing unique local encryption key data correspondingly associated with a sender, and providing unique remote encryption key data correspondingly associated with a receiver. In addition, the method includes orienting the electronic file in an encrypted mode by utilizing at least one set of the unique local encryption key data and at least one set of the remote encryption key data. | 03-19-2009 |
20090077390 | Electronic file protection system having one or more removable memory devices - The electronic file protection system includes at least one first memory device removably disposable in communicative relation with one or more computers, wherein the first memory device includes a unique identifier. The system further includes unique, non-reproducible encryption key data disposed or otherwise saved on the first memory device. The encryption key data is structured to be utilized in conjunction with at least one encryption algorithm so as to at least partially protect the electronic file, or otherwise orient the electronic file in an encrypted mode. Further, the unique identifier is reproducible and disposable in associated relation with a replacement memory device. | 03-19-2009 |
Angel Fernandez-Gonzalez, Valladolid ES
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20120152268 | ENCAPSULATES - Encapsulates, compositions, packaged products and displays comprising such encapsulates, and processes for making and using such encapsulates, compositions, packaged products and displays. Such compositions have improved deposition and retention properties that may impart improved benefit characteristics to a composition and/or situs. | 06-21-2012 |
Angel Gil Hernandez, Granada ES
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20120076829 | ISOLATION, IDENTIFICATION AND CHARACTERISATION OF STRAINS WITH PROBIOTIC ACTIVITY, FROM FAECES OF INFANTS FED EXCLUSIVELY WITH BREAST MILK - The invention relates to probiotic micro-organisms isolated from faeces of children exclusively fed with breast milk. Said microorganisms are used in the food or pharmaceutical industry, especially for use in infant formula milk, due to their probiotic properties which have beneficial effects on the health of those ingesting them. Said microorganisms consist of | 03-29-2012 |
20130280789 | ISOLATION, IDENTIFICATION AND CHARACTERISATION OF STRAINS WITH PROBIOTIC ACTIVITY, FROM FAECES OF INFANTS FED EXCLUSIVELY WITH BREAST MILK - The invention relates to probiotic micro-organisms isolated from feces of children exclusively fed with breast milk. Said microorganisms are used in the food or pharmaceutical industry, especially for use in infant formula milk, due to their probiotic properties which have beneficial effects on the health of those ingesting them. Said microorganisms consist of | 10-24-2013 |
20130280790 | ISOLATION, IDENTIFICATION AND CHARACTERISATION OF STRAINS WITH PROBIOTIC ACTIVITY, FROM FAECES OF INFANTS FED EXCLUSIVELY WITH BREAST MILK - The invention relates to probiotic micro-organisms isolated from faeces of children exclusively fed with breast milk. Said microorganisms are used in the food or pharmaceutical industry, especially for use in infant formula milk, due to their probiotic properties which have beneficial effects on the health of those ingesting them. Said microorganisms consist of | 10-24-2013 |
Angel Gil Hernandez, Badajoz ES
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20090137459 | Food Product for Enteral or Oral Nutrition - This invention relates to a food product for enteral or oral nutrition, comprising a novel protein mixture, a novel lipid mixture, as well as carbohydrates, soluble and insoluble fibre, vitamins and minerals, composing a nutritional product adequate for pathologic conditions where there is some kind of impairment to meet nutritional needs with a normal oral diet. | 05-28-2009 |
20090252853 | Lipid Mixture and Use Thereof in the Preparation of a Product That Is Intended for Enteral or Oral Administration - This invention relates to a novel mixture of lipids and the use thereof for preparing a food product intended for oral or enteral nutrition wherein the lipid mixture has a balanced and adequate fatty acid profile specially suited for using the same in complete nutritional products for oral or enteral administration. Such fatty acid profile, from vegetable and fish oils, provides a relatively low content of saturated fatty acids, a high content of medium-chain and monounsaturated fatty acids (oleic acid) and a balanced supply of essential (linoleic and α-linolenic) fatty acids, as well as long-chain polyunsaturated fatty acids of the Omega 3 series (n-3). | 10-08-2009 |
20100292168 | Protein Mixture and Use Thereof in the Preparation of a Product that is Intended for Oral or Enteral Administration - This invention relates to a novel protein mixture and the use thereof in the preparation of a food product intended for oral or enteral nutrition. This protein mixture, based on caseinate, pea proteins and milk serum proteins has very high protein quality indices (protein efficiency index) and a good digestibility, thus the ease of conversion of said protein mixture is very good when compared to that of superior-quality highly-digestible proteins per excellence. | 11-18-2010 |
20110053888 | Mixture Of Carboyhydrates And Its Use In The Preparation Of A Product Intended For Oral Or Enteral Nutrition - The present invention is related to a new mixture of carbohydrates and its usage for the preparation of a food product intended for oral or enteral nutrition, particularly for the nutrition of the diabetic patient and in particular for the nutrition of the diabetes type II patient and their associated comorbidity. The carbohydrate mixture of the present invention is formed by type IV or RS IV (modified maltodextrins) resistant starch, maltodextrin of low dextrose equivalent DE=5-8, preferably DE equal to 6, insulin and cellulose and is exempt from fructose. | 03-03-2011 |
20130136800 | Enteral Or Oral Food Product Intended, In Particular, For nutrition And For The Prevention And Improvement Of Neurological Alterations, Neurodegenerative Alterations or Cognitive Disorders - The present invention relates to a complete food product for specific nutritional use, especially intended for enteral or oral nutrition of patients who suffer neurological or neurodegenerative alterations, and for the prevention of cognitive or behaviour disorders, especially in the case of elderly persons, such food product comprising a functional ingredient especially conceived for the nourishment of patients suffering from, or prone to neurological or neurodegenerative alterations, cognitive deterioration or behaviour disorders, as well as a mixture of carbohydrates, a mixture of proteins, a mixture of lipids and dietary fibre, inulin, vitamins and minerals. | 05-30-2013 |
20130172286 | Functional Food Supplement Intended, In Particular, For Nutrition And For Prevention And Improvement of Neurological Alterations, Neurodegenerative Alterations Or Cognitive Disorders - This invention relates to a functional food supplement, specifically intended to supplement the enteral or oral nutrition of patients with neurological or neurodegenerative alterations, and for the prevention of cognitive or behaviour disorders, especially in the case of elderly persons, where the functional ingredient especially conceived for the nourishment of patients suffering from, or prone to neurological or neurodegenerative alterations, cognitive deterioration or behaviour disorders comprises a mixture of UMP (uridine monophosphate or uridine) and/or IMP (inosine monophosphate or inosine), vitamins of the B group (B1, B6, B9 and B7), phospholipids and gangliosides and sialic acid, as well as a large amount of DHA. | 07-04-2013 |
Angel Gomez-Rojo, Guadalajara ES
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20110270439 | AUTOMATIC APPARATUS FOR SELECTING, DISPENSING AND COLLECTING RE-USABLE ITEMS - The present invention relates to an automatic apparatus for selecting, dispensing and collecting re-usable items comprising at least one user interface comprising a computer for selecting re-usable items and at least one device for dispensing and/or collecting re-usable items, a storage system for storing the re-usable items, a transportation system for transferring the re-usable items between the storage system and the at least one device for dispensing and/or collecting re-usable items, wherein the re-usable items are stored and transferred within the apparatus by means of carriers but dispensed and/or collected carrier-less. | 11-03-2011 |
Angel Guzman-Perez, Mystic, CT US
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20090118316 | Methods for Augmenting Bone - The present invention relates to methods of stimulating osteoblast function with a PYK2 inhibitor in subjects with osteoporosis, bone fractures, non-unions, pseudoarthroses, periodontal disease or other disorders of bone metabolism. Optionally, the method further comprises administration of a second therapeutic bone agent. The present invention also relates to methods to identify a PYK2 inhibitor effective as a therapeutic bone agent comprising administering a test agent to an osteoblast-like cell and determining if osteoblast function is stimulated. Optionally, the identifying method further comprises contacting the test agent with PYK2 and determining if PYK2 activity is inhibited. | 05-07-2009 |
20110028452 | PYRIDO[4,3-d]PYRIMIDIN-4(3H)-ONE DERIVATIVES AS CALCIUM RECEPTOR ANTAGONISTS - The present invention is directed to novel pyrido[4,3-d]pyrimidin-4(3H)-one derivatives and pharmaceutically acceptable salts thereof of structural formula I | 02-03-2011 |
20110319379 | Substituted Indazole Amides And Their Use As Glucokinase Activators - The present invention provides a compound of Formula (I) or a pharmaceutically acceptable salt thereof wherein R | 12-29-2011 |
Angel Guzman-Perez, Belmont, MA US
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20120165343 | Glucagon Receptor Modulators - The present invention provides a compound of Formula (I) | 06-28-2012 |
20120202834 | GLUCAGON RECEPTOR MODULATORS - The present invention provides a compound of Formula (I) | 08-09-2012 |
20130296355 | GLUCAGON RECEPTOR MODULATORS - The present invention provides a compound of Formula (I) | 11-07-2013 |
20140107109 | AMINO-DIHYDROTHIAZINE AND AMINO-DIOXIDO DIHYDROTHIAZINE COMPOUNDS AS BETA-SECRETASE ANTAGONISTS AND METHODS OF USE - The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: | 04-17-2014 |
20140135338 | QUINOLINYL GLUCAGON RECEPTOR MODULATORS - The present invention provides a compound of Formula I or a pharmaceutically acceptable salt thereof, wherein R | 05-15-2014 |
20140275058 | PERFLUORINATED CYCLOPROPYL FUSED 1,3-OXAZIN-2-AMINE COMPOUNDS AS BETA-SECRETASE INHIBITORS AND METHODS OF USE - The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: | 09-18-2014 |
20140329862 | Glucagon Receptor Modulators - The present invention provides a compound of Formula (I) | 11-06-2014 |
20140371201 | BICYCLIC SULFONAMIDE COMPOUNDS AS SODIUM CHANNEL INHIBITORS - The present invention provides compounds of Formula I, | 12-18-2014 |
20140371467 | GLUCAGON RECEPTOR MODULATORS - The present invention provides a compound of Formula (I) | 12-18-2014 |
20150038497 | BRIDGED BICYCLIC AMINO THIAZINE DIOXIDE COMPOUNDS AS INHIBITORS OF BETA-SECRETASE AND METHODS OF USE THEREOF - The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: | 02-05-2015 |
20150045368 | OXAZOLIDINONE COMPOUNDS AND DERIVATIVES THEREOF - Compounds of Formula (I) and Formula (II) are useful inhibitors of tankyrase. Compounds of Formula (I) and Formula (II) have the following structure: where the definitions of the variables are provided herein. | 02-12-2015 |
20150094338 | Glucagon Receptor Modulators - The present invention provides a compound of Formula (I) | 04-02-2015 |
20150099882 | QUINOLINYL GLUCAGON RECEPTOR MODULATORS - The present invention provides a compound of Formula I | 04-09-2015 |
20150225396 | Quinazolinone Compounds and Derivatives Thereof - Compounds of Formula I are useful inhibitors of tankyrase. Compounds of Formula I have the following structure: where the definitions of the variables are provided herein. | 08-13-2015 |
20150252011 | PERFLUORINATED CYCLOPROPYL FUSED 1,3-OXAZIN-2-AMINE COMPOUNDS AS BETA-SECRETASE INHIBITORS AND METHODS OF USE - The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: | 09-10-2015 |
20150252059 | BRIDGED BICYCLIC AMINO THIAZINE DIOXIDE COMPOUNDS AS INHIBITORS OF BETA-SECRETASE AND METHODS OF USE THEREOF - The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: | 09-10-2015 |
20150259308 | AMINO-DIHYDROTHIAZINE AND AMINO-DIOXIDO DIHYDROTHIAZINE COMPOUNDS AS BETA-SECRETASE ANTAGONISTS AND METHODS OF USE - The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: wherein variables A | 09-17-2015 |
20150266859 | GLUCAGON RECEPTOR MODULATORS - The present invention provides a compound of Formula (I) | 09-24-2015 |
20150266861 | Glucagon Receptor Modulators - The present invention provides a compound of Formula (I) | 09-24-2015 |
20150353508 | QUINOLINYL GLUCAGON RECEPTOR MODULATORS - The present invention provides a compound of Formula I | 12-10-2015 |
20160046618 | Cyclopropyl Fused Thiazin-2-Amine Compounds as Beta-Secretase Inhibitors and Methods of Use - The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: | 02-18-2016 |
20160046626 | BICYCLIC SULFONAMIDE COMPOUNDS AS SODIUM CHANNEL INHIBITORS - The present invention provides compounds of Formula I, | 02-18-2016 |
Angel Ibañez Ceba, Salinas De Pamplona (navarra) ES
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20120124796 | SYSTEM FOR PRODUCING COMPOSITE BEAMS AND FLOOR STRUCTURES OF BUILDINGS BY MEANS OF BENT SECTIONS MADE OF STEEL AND ANOTHER MATERIAL ATTACHED BY MEANS OF CONNECTORS FORMED IN THE SECTION MADE OF STEEL - The present invention relates to a system for producing composite beams and floor structures of buildings by means of bent sections made of steel and another material attached by means of connectors formed in the section made of steel, made up of sections ( | 05-24-2012 |
Angel Janevski, New York, NY US
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20080228405 | Search Space Coverage With Dynamic Gene Distribution - A method and apparatus for selecting measurements from a plurality of measurements is disclosed. The method includes the steps of initializing a measurement status to a first value for each of the measurements, determining selectability of one of the plurality of measurements based on a corresponding status value, and updating the status to a second value after selecting the measurement. In one aspect of the invention, the step of determining selectability further comprises the step of selecting one of the plurality of measurements, and retaining the selected measurement when the value of the corresponding status is the first value. | 09-18-2008 |
20080234944 | Method and Apparatus for Subset Selection with Preference Maximization - A method and apparatus for determining a subset of measurements from a plurality of measurements in a genetic algorithm is disclosed. The method comprising the steps of determining a fitness measure for each sub-set of the measurements, wherein each measurement has an associated fitness measure and selecting the subset of measurements having the lowest fitness measure ( | 09-25-2008 |
20110173201 | METHOD OF DETERMINING A RELIABILITY INDICATOR FOR SIGNATURES OBTAINED FROM CLINICAL DATA AND USE OF THE RELIABILITY INDICATOR FOR FAVORING ONE SIGNATURE OVER THE OTHER - This invention relates to a method and an apparatus for determining a reliability indicator for at least one set of signatures obtained from clinical data collected from a group of samples. The signatures are obtained by detecting characteristics in the clinical data from the group of sample sand each of the signatures generate a first set of stratification values that stratify the group of samples. At least one additional and parallel stratification source to the signatures obtained from group of sample sis provided, the at least one additional and parallel stratification source to the signatures being independent from the signatures and generates a second set of stratification values. A comparison is done for each respective sample, where the first stratification values are compared with a true reference stratification values, and where the second stratification values are compared with the true reference stratification values. The signatures are assigned with similarity measure indicators indicating whether the first and the second stratification values match with the true reference stratification values. These are then implementing as input in determining the reliability of the signatures. | 07-14-2011 |
20120004118 | METHODS FOR THE SUBCLASSIFICATION OF BREAST TUMOURS - Provided is a method for the analysis of breast cancer disorders, comprising determining the genomic methylation status of one or more CpG dinucleotides. Furthermore, a computer program product stored on a computer-readable medium comprising software code adapted to perform the steps of the method when executed on a data-processing apparatus is provided. A device comprising means for supporting a clinician is also provided. | 01-05-2012 |
20120265446 | BIOMARKERS BASED ON SETS OF MOLECULAR SIGNATURES | 10-18-2012 |
20130102483 | METHODS FOR THE ANALYSIS OF BREAST CANCER DISORDERS - The present invention relates to methods, arrays and computer programs for assisting in classifying breast cancer diseases. In particular the invention relates to classifying breast cancer disorders by determining the methylation status of one or more sequences according to SEQ ID NO: 1-111. The classification may be further strengthened by also taking the expression levels of one or more proteins into account. | 04-25-2013 |
20130196877 | IDENTIFICATION OF MULTI-MODAL ASSOCIATIONS BETWEEN BIOMEDICAL MARKERS - The present invention relates to a method for identifying multi-modal associations between biomedical markers which allows for the determination of network nodes and/or high ranking network members or combinations thereof, indicative of having a diagnostic, prognostic or predictive value for a medical condition, in particular ovarian cancer. The present invention further relates to a biomedical marker or group of biomedical markers associated with a high likelihood of responsiveness of a subject to a cancer therapy, preferably a platinum based cancer therapy, wherein said bio-medical marker or group of biomedical markers comprises at least 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 8, 19, 20 or all markers selected from PKMYT1, SKIL, RAB8A, HIRIP3, CTNNB1, NGFR, ZCCHC11, LSP1, CD200, PAX8, CYBRD1, HOXC11, TCEAL1, FZD10,FZD1, BBS4, IRS2, TLX3, TSPAN2, TXN, and CFLAR. Furthermore, an assay for detecting, diagnosing, graduating, monitoring or prognosticating a medical condition, or for detecting, 1 diagnosing, monitoring or prognosticating the responsiveness of a subject to a therapy against said medical condition, in particular ovarian cancer, is provided, as well as a corresponding method for classifying a subject comprising and a medical decision support system. | 08-01-2013 |
20130282404 | INTEGRATED ACCESS TO AND INTERATION WITH MULTIPLICITY OF CLINICA DATA ANALYTIC MODULES - A state machine ( | 10-24-2013 |
20140040264 | METHOD FOR ESTIMATION OF INFORMATION FLOW IN BIOLOGICAL NETWORKS - The present invention relates to a method for stratifying a patient into a clinically relevant group comprising the identification of the probability of an alteration within one or more sets of molecular data from a patient sample in comparison to a database of molecular data of known phenotypes, the inference of the activity of a biological network on the basis of the probabilities, the identification of a network information flow probability for the patient via the probability of interactions in the network, the creation of multiple instances of network information flow for the patient sample and the calculation of the distance of the patient from other subjects in a patient database using multiple instances of the network information flow. The invention further relates to a biomedical marker or group of biomedical markers associated with a high likelihood of responsiveness of a subject to a cancer therapy wherein the biomedical marker or group of biomedical markers comprises altered biological pathway markers, as well as to an assay for detecting, diagnosing, graduating, monitoring or prognosticating a medical condition, or for detecting, diagnosing, monitoring or prognosticating the responsiveness of a subject to a therapy against said medical condition, in particular ovarian cancer. Furthermore, a corresponding clinical decision support system is provided. | 02-06-2014 |
20140107936 | CROSS-MODAL APPLICATION OF COMBINATION SIGNATURES INDICATIVE OF A PHENOTYPE - The present invention relates to a method of adapting a composite signature of a phenotype. The method comprises the steps of providing for a composite signature of a phenotype with at least two different data types, which were respectively generated by two different modalities of measuring a specimen. Due to an adaption of one part of the signature of the phenotype the resulting adapted phenotype signature can be used as an input for a signature evaluation tool that was derived from data measured by a third modality of measurement. | 04-17-2014 |
20140365243 | RETROACTIVE EXTRACTION OF CLINICALLY RELEVANT INFORMATION FROM PATIENT SEQUENCING DATA FOR CLINICAL DECISION SUPPORT - A catalog ( | 12-11-2014 |
20140379379 | SYSTEM AND METHOD FOR REAL TIME CLINICAL QUESTIONS PRESENTATION AND MANAGEMENT - In a clinical decision support method, outputs of computer-implemented analytical modules are computed for a patient. Information is displayed for the patient pertaining to a clinical question comprising outputs computed for the patient of analytical modules associated with the clinical question. The analytical modules may include modules configured to perform in silico genetic/genomic tests using genetic/genome sequencing (whole genome, whole exome, whole transcriptome, targeted gene panels, etc) or microarray data. A clinical question-module matrix (CQ-M matrix) may be generated for the patient associating clinical questions with analytical modules, and the method may further include populating the clinical questions with outputs computed for the patient of the analytical modules associated with the clinical questions by the CQ-M matrix. Such populating advantageously re-uses outputs computed for the patient when an analytical module is associated with two or more different clinical questions by the CQ-M matrix. This system empowers the clinician to focus on the clinical aspects of patient management while allowing the data complexities of patient genomic data interpretation to be handled by the clinical decision support system. | 12-25-2014 |
20150058322 | PATHWAY VISUALIZATION FOR CLINICAL DECISION SUPPORT - When generating visual representations of gene activity pathways for clinical decision support, a validated pathway database that stores a plurality of validated pathways is accessed, wherein each pathway describes at least one interaction between a plurality of genes. A processor ( | 02-26-2015 |
20150097868 | CLINICAL WORKSTATION INTEGRATING MEDICAL IMAGING AND BIOPSY DATA AND METHODS USING SAME - An imaging visualization workstation ( | 04-09-2015 |
20150294063 | DIAGNOSTIC GENETIC ANALYSIS USING VARIANT-DISEASE ASSOCIATION WITH PATIENT-SPECIFIC RELEVANCE ASSESSMENT - Relevance of a study genetic variant observed in diagnostic subject genetic data that is associated by a clinical study with a phenotype characteristic is assessed as follows. A set of polymorphisms functionally related to the study genetic variant are identified. A foreground distribution is computed of variants observed in the diagnostic subject genetic data for the set of polymorphisms. A background distribution is computed of variants observed in genetic data of subjects of the clinical study for the set of polymorphisms. A comparison metric is computed comparing the foreground distribution and the background distribution. Relevance of the study variant to the diagnostic subject is quantified based on the comparison metric, with higher similarity of the foreground and background distributions corresponding to higher relevance. | 10-15-2015 |
20150310632 | INTEGRATED PHENOTYPING EMPLOYING IMAGE TEXTURE FEATURES - Image texture feature values are computed for a set of image texture features from an image of an anatomical feature of interest in a subject, and the subject is classified respective to a molecular feature of interest based on the computed image texture feature values. The image texture feature values may be computed from one or more gray level co-occurrence matrices (GLCMs), and the image texture features may include Haralick and/or Tamura image texture features. To train the classifier, reference image texture feature values are computed for at least the set of image texture features from images of the anatomical feature of interest in reference subjects. The reference image texture feature values are divided into different population groups representing different values of the molecular feature of interest, and the classifier is trained to distinguish between the different population groups based on the reference image texture feature values. | 10-29-2015 |
20150347679 | PREDICTIVE OUTCOME ASSESSMENT FOR CHEMOTHERAPY WITH NEOADJUVANT BEVACIZUMAB - In a predictive outcome assessment test for predicting whether a patient undergoing a breast cancer treatment regimen will achieve pathological complete response (pCR), differential gene expression level information are generated for an input set of genes belonging to the TGF-β signaling pathway. The differential gene expression level information compares baseline gene expression level information from a baseline sample ( | 12-03-2015 |
20160085943 | System and Method for Monitoring Clinical Trial Progress - A method for monitoring clinical trial progress includes calculating progress curves for clinical trial states. Calculating a progress curve includes assigning values to events for a datapoint in the clinical trial, generating or building pairs of values for each consecutive sequence of the events, summing up the values of pairs of events corresponding to a state change, and determining a state for the datapoint based on the sum of the values. Monitoring clinical trial progress then includes calculating a second progress curve for another clinical trial state and comparing the delay between points of the progress curves. A system for monitoring clinical trial progress is also described. | 03-24-2016 |
Angel Janevski, Briarcliff Manor, NY US
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20110281756 | COMPOSITIONS AND METHODS FOR MICRO-RNA EXPRESSION PROFILING OF COLORECTAL CANCER - The present invention relates compositions and methods for microRNA (miRNA) expression profiling of colorectal cancer. In particular, the invention relates to a diagnostic kit of molecular markers for identifying one or more mammalian target cells exhibiting or having a predisposition to develop colorectal cancer, the kit comprising a plurality of nucleic acid molecules, each nucleic acid molecule encoding a miRNA sequence, wherein one or more of the plurality of nucleic acid molecules are differentially expressed in the target cells and in one or more control cells, and wherein the one or more differentially expressed nucleic acid molecules together represent a nucleic acid expression signature that is indicative for the presence of or the predisposition to develop colorectal cancer. The invention further relates to corresponding methods using such nucleic acid expression signatures for identifying one or more mammalian target cells exhibiting or having a predisposition to develop colorectal cancer as well as for preventing or treating such a condition. Finally, the invention is directed to a pharmaceutical composition for the prevention and/or treatment of colorectal cancer. | 11-17-2011 |
Angel Joern, Bochum DE
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20080301404 | METHOD FOR CONTROLLING AN ELECTRONIC CIRCUIT AND CONTROLLING CIRCUIT - A method for controlling an electronic circuit including selecting at least one pre-stored generating rule from a plurality of pre-stored generating rules according to which a message which is to be transmitted to the electronic circuit for carrying out a controlling function to control the electronic circuit is to be generated, and generating the message according to the at least one selected generating rule. | 12-04-2008 |
Angel Kaifer, Coral Gables, FL US
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20120093761 | VACCINE COMPOSITIONS AND METHODS OF USE THEREOF - Nanoparticle-based vaccines, compositions, kits and methods are used for the effective delivery of one or more antigens in vivo for vaccination and antibody (e.g., monoclonal antibody) production, and for the effective delivery of peptides, proteins, siRNA, RNA or DNA to PAPCs or MHC class II positive cells (e.g. tumor cells). Antigens may be, for example, DNA that results in expression of the gene of interest and induction of a robust and specific immune response to the expressed protein in a subject (e.g., mammal). Antigens may also be immunogenic peptides or polypeptides that are processed and presented. In one embodiment, a nanoparticle -based method to deliver antigens in vivo as described herein includes injection of a vaccine composed of a DNA encoding at least one antigen, or at least one antigenic peptide or polypeptide conjugated to a charged dendrimer (e.g., PADRE-derivatized dendrimer) that is also conjugated to a T helper epitope (e.g., PADRE). Negatively-charged plasmids bind naturally to a positively-charged PADRE-dendrimer, while peptide or polypeptide antigens can be chemically linked to the PADRE-dendrimer if they are not negatively-charged. Alternatively, negatively-charged dendrimers may be used. The compositions, kits, vaccines and methods described herein have both prophylactic and treatment applications, i.e., can be used as a prophylactic to prevent onset of a disease or condition in a subject, as well as to treat a subject having a disease or condition. A vaccine as described herein can be used to mount an immune response against any infectious pathogen or cancer. | 04-19-2012 |
20120129199 | COMPOSITIONS, KITS AND METHODS FOR IN VITRO ANTIGEN PRESENTATION, ASSESSING VACCINE EFFICACY, AND ASSESSING IMMUNOTOXICITY OF BIOLOGICS AND DRUGS - Nanoparticle-based compositions, assays, kits, methods and platforms for delivering an antigen (peptides, proteins) or a nucleic acid encoding an antigen to professional APCs (PAPCs) result in the generation of autologous APCs that present a natural peptide repertoire of the antigen for use in assessing the efficacy of a vaccine (e.g., a cytotoxic T lymphocyte (CTL) response to a particular antigen) or other therapy or intervention (cell-based therapy, adjuvant therapy, etc.). The compositions, kits, assays and methods also can be used for delivering a drug or biologic or portion thereof to APCs for assessing the immunogenicity of drugs and biologics. The composition, kits, assays and methods involve the combined use of MHC targeting, universal DR binding peptides (e.g., PADRE, HA) with charged (e.g., positively-charged) highly branched polymeric dendrimers (e.g., PAMAM and other dendrimers) as vehicles for the targeted delivery of nucleic acids, peptides, biologics, drugs, or polypeptides to APCs, giving rise to a new nanoparticle-based method for assessing the immune response (CTL response) to a vaccination or other therapy or intervention, or for assessing the immunogenicity of a biologic or drug. Targeted delivery of nucleic acids, peptides, biologics, drugs, or polypeptides to APCs for effective expression and processing generates more physiologically relevant target antigens for evaluation of cell-mediated immune responses to vaccination, for example, and provides a low-cost approach for rapid generation of reagents and development of assay systems for more accurate profiling of immunological responses to infection, immunization, and other therapies or interventions. Immunoevaluation kits using targeted nanoparticle-based antigen delivery are described herein. | 05-24-2012 |
Angel Lopez Buendia, Valencia ES
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20100192809 | PORTLAND CEMENT TO WHICH TEXTURED POZZOLANS ARE ADDED - The invention relates to different compounds of Portland cement to which textured pozzolans are added, said compounds being obtained by known physical atomisation, palletisation, granulation treatments or a combination of same, generating changes in the primitive global morphology of the compounds. | 08-05-2010 |
Angel Lopez Redondo, Getafe (madrid) ES
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20090159095 | Procedure for the preparation and cleaning of tools used for manufacturing composite material components, and the corresponding device - The procedure includes: a first phase of blowing and suction; a second phase of cleaning by laser where the tool ( | 06-25-2009 |
Angel Lopz, Adelaide AU
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20100260744 | REGULATING IL-4 AND IL-13 LEVELS BY BLOCKING HIGH AFFINITY BINDING BY IL-3, IL-5 AND GM-CSF TO THEIR COMMON RECEPTOR - A method of reducing IL-4 and/or IL-13 levels in the lung of a mammal with elevated levels thereof, includes the step of administering to the mammal an effective amount of a βc receptor blocker capable of blocking the binding of all three of IL-3, IL-5 and GM-CSF to the βc common chain to thereby reduce the IL-4 and/or IL-13 levels. | 10-14-2010 |
Angel Machin Garcia, Madrid ES
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20100325313 | METHOD AND SYSTEM OF MIGRATING PROFILES IN TELECOMMUNICATIONS DEVICES - A method of migrating a user profile from a first device to a second device. Firstly, a request is made ( | 12-23-2010 |
Angel Marfinez, Barcelona ES
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20090128599 | METHOD AND PRINTER FOR MULTI-PASS PAGE-WIDE ARRAY PRINTING - A method of printing an image on a substrate using a page-wide-array printer and a page wide array printer is provided. The method comprises printing a first portion of the image as relative movement occurs between the substrate and the print heads, and printing a second portion of the image as relative movement occurs between the substrate and the print heads, such that there exists an area of overlap between the first portion of the image and the second portion of the image. The substrate may be moved in a first direction relative to the print heads whilst the first portion of the image is printed, moved in a second direction opposite to the first direction; and moved in the first direction again whilst the second portion of the image is printed. The substrate may be printed whilst the substrate is moved in the second direction. | 05-21-2009 |
Angel Martin Da Silva, Madrid ES
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20110215577 | WIND TURBINE CONTROL METHODS FOR IMPROVING THE PRODUCTION OF ENERGY RECOVERING ENERGY LOSSES - Method of operation of a variable speed wind turbine ( | 09-08-2011 |
Angel Martinez Alcolea, Madrid ES
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20120129112 | Method Of And A System For Combusting Fuel In An Oxyfuel Combustion Boiler - A method of and a system for combusting fuel in an oxyfuel combustion boiler. Fuel is fed to a furnace of the boiler. Oxidant gas that includes a mixture of substantially pure oxygen and recycled flue gas is fed to the furnace, prior to the feeding of the oxidant gas. At least a portion of the oxidant gas is preheated to generate preheated oxidant gas. The fuel is combusted with the oxidant gas in the furnace so as to generate steam and to produce the flue gas, and at least a portion of the steam is superheated to generate superheated steam. The preheating of the at least a portion of the oxidant gas is performed by using a heat exchanger that transfers heat from a portion of the superheated steam to the oxidant gas. | 05-24-2012 |
Angel Martinez Leon, Alicante ES
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20090176605 | FOLDING TABLE - The invention relates to a folding table comprising: a board which is formed by two articulated halves ( | 07-09-2009 |
Angel Messeguer, Barcelona ES
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20120237552 | Peptoid Agonists of Nerve Growth Factor and Their Use as Medicaments - Neurotrophin binding to its specific receptors Trk A and p75 leads to the activation of multiple signalling cascades, culminating in neuroprotective and regenerative effects, including neuronal survival and neurite outgrowth. Neurotrophic factors have been used for the treatment of several neurodegenerative diseases. However, their use is limited by their inability to cross the blood-brain barrier, their short half life and their side effects. Small molecule neurotrophin mimetics may be beneficial in treating a number of neurodegenerative disorders. The present invention shows the capacity of nerve growth factor agonist molecules of Formulae I-IV, as defined in the specification, to induce differentiation in PC 12 cells, promote survival in RN22 cells and activate Trk A, IkBa and SAPK/JNK phosphorylation to various extents in both cell lines. In addition these molecules were able to ameliorate acute experimental autoimmune encephalomyelitis (EAE), a multiple sclerosis (MS) animal model, inhibiting brain inflammation and reducing brain damage. We also observed suppression in the production of pro-inflammatory genes like the inducible nitric oxide synthase. These small molecules with NGF agonist activity may be beneficial for MS and other neurodegenerative diseases due to its neuroprotective and immunomodulatory properties. | 09-20-2012 |
Angel Millán Escolano, Zaragoza ES
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20120183012 | LUMINESCENT ORGANIC/INORGANIC MATRIX, METHOD FOR THE PRODUCTION THEREOF AND LUMINESCENT MOLECULAR THERMOMETER BASED ON SAID MATRIX - Thermometer comprising an organic-inorganic matrix which comprises tris complex (β-diketonate) of two different cations of lanthanide elements. In addition, the invention also relates to the matrix, methods for preparing it and methods of using a thermometer to measure absolute temperatures. | 07-19-2012 |
Angel Moracho Jimenez, Tudela (navarra) ES
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20110286794 | PAVING STONE AND METHOD FOR THE PRODUCTION THEREOF - Paving stone ( | 11-24-2011 |
Angel Morales-Ramos, Blue Bell, PA US
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20110071126 | INHIBITORS OF BETA-SECRETASE - The present invention is directed to a compound represented by the following structural formula | 03-24-2011 |
20130053377 | INHIBITORS OF BETA-SECRETASE - The present invention relates to compounds represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof. Definitions for the variables are provided herein. | 02-28-2013 |
20130289050 | INHIBITORS OF BETA-SECRETASE - The present invention relates to spirocyclic acylguanidines and their use as inhibitors of the β-secretase enzyme (BACE1) activity, pharmaceutical compositions containing the same, and methods of using the same as therapeutic agents in the treatment of neurodegenerative disorders, disorders characterized by cognitive decline, cognitive impairment, dementia and diseases characterized by production of β-amyloid aggregates. | 10-31-2013 |
20140057927 | INHIBITORS OF BETA-SECRETASE - The present invention relates to spirocyclic acylguanidines and their use as inhibitors of the β-secretase enzyme (BACE1) activity, pharmaceutical compositions containing the same, and methods of using the same as therapeutic agents in the treatment of neurodegenerative disorders, disorders characterized by cognitive decline, cognitive impairment, dementia and diseases characterized by production of β-amyloid aggregates. | 02-27-2014 |
20140200223 | INHIBITORS OF BETA-SECRETASE - The present invention is directed to a compound represented by the following structural formula | 07-17-2014 |
20150031691 | INHIBITORS OF BETA-SECRETASE - The present invention relates to compounds represented by Structural Formula (I): | 01-29-2015 |
20150150872 | INHIBITORS OF BETA-SECRETASE - The present invention relates to spirocyclic acylguanidines and their use as inhibitors of the β-secretase enzyme (BACE1) activity, pharmaceutical compositions containing the same, and methods of using the same as therapeutic agents in the treatment of neurodegenerative disorders, disorders characterized by cognitive decline, cognitive impairment, dementia and diseases characterized by production of β-amyloid aggregates. | 06-04-2015 |
20150239849 | INHIBITORS OF BETA-SECRETASE - The present invention relates to spirocyclic acylguanidines and their use as inhibitors of the β-secretase enzyme (BACE1) activity, pharmaceutical compositions containing the same, and methods of using the same as therapeutic agents in the treatment of neurodegenerative disorders, disorders characterized by cognitive decline, cognitive impairment, dementia and diseases characterized by production of β-amyloid aggregates. | 08-27-2015 |
Angel Oñate Contreras, Concepcion CL
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20110200667 | VETERINARY PHARMACEUTICAL FORMULACION THAT COMPRISES AN RNA RECOMBINANT PARTICLE THAT ENCODES FOR A CU/ZN SUPEROXIDE DISMUTASE PROTEIN OF RUMINANT PATHOGENIC BACTERIA AND AT LEAST ONE RNA ALPHAVIRUS BELONGING TO THE SEMLIKI FOREST VIRUS FAMILY - The technology is a veterinary pharmaceutical formulation of two vaccines, one from an RNA viral vector system constituted by an RNA recombinant particle that codifies for a Cu/Zn superoxide dismutase protein of | 08-18-2011 |
Angel Ortega Valero, Valencia ES
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20110224290 | COMBINE USE OF PTEROSTILBENE AND QUERCETIN FOR THE PRODUCTION OF CANCER TREATMENT MEDICAMENTS - The invention relates to the combined use of pterostilbene and quercetin for the production of cancer treatment medicaments. The in vitro growth of melanoma cells B16-F10 (B16M-F10) is inhibited (56%) by combined exposures of short duration (60 min/day) to PTER (40 μM)+QUER (20 μM) (˜average values of plasma concentrations measured within the first hour following the IV administration of 20 mg of each polyphenol/kg ˜). The combined intravenous administration of PTER+QUER (20 mg/kg×day) to mice inhibits (73%) the metastatic growth of melanoma B16M-F10 in the liver, a common site for metastasis development. The invention demonstrates that the combination of PTER+QUER inhibits the growth of malignant melanoma metastasis and prolongs the survival of the carrier host. | 09-15-2011 |
Angel Pascual Fuertes, Alcobendas (madrid) ES
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20120138738 | SYSTEM FOR INCREASING CONTROLLABILITY FOR AN AIRCRAFT - The system includes deflection transmission means ( | 06-07-2012 |
Angel Pellicer, New York, NY US
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20080219993 | HUMAN RGR ONCOGENE AND TRUNCATED TRANSCRIPTS THEREOF DETECTED IN T CELL MALIGNANCIES, ANTIBODIES TO THE ENCODED POLYPEPTIDES AND METHODS OF USE - Naturally-occurring variants of human Rgr oncogene protein, in particular, abnormally truncated variants found in T cell malignancies, as well as the human Rgr protein are encompassed by the present invention. Also included are antibodies thereto and nucleic acid molecules encoding human Rgr protein and naturally-occurring variants thereof. The present invention further provides methods for diagnosing and treating T cell malignancies associated with abnormally truncated transcripts of human rgr oncogene and/or abnormal truncation of human Rgr protein. | 09-11-2008 |
Angel Perales Fayos, Fuente De La Higuera - Valencia ES
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20110070754 | CONNECTORS WITH BRUSHES AND PINS WHICH SLIDE ALONG ELECTRICAL GUIDES FOR HOME, BUSINESS OR INDUSTRIAL INSTALLATIONS - Female connectors which slide along some guides in home, business or industrial installations and allow electricity to be transported from one point to another without the need for extension cables. The connector slides along the guide which includes, in the interior thereof, some electrical brushes connected to some brass connectors which transport the electricity towards the poles of a male connector from some tracks which, in turn, are connected to the mains or the general electrical installation. Alternatively, the connector slides along some guides having electrical pins which are connected to the general electrical installation via the tracks. | 03-24-2011 |
Angel Perero Lorenz, Huesca ES
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20110313321 | METHOD AND DEVICE FOR OBTAINING A PLANTAR IMAGE AND DOUBLE-SIDED MACHINING OF THE INSOLE THUS OBTAINED - Method for obtaining a plantar image using means for securing and tightening an elastic membrane, as well as to the double-sided machining of the obtained insole, said means taking the form of two adjustable horizontal bars positioned on a scanner or a plurality of cameras and an anti-reflective lens, wherein a membrane is positioned between said horizontal bars and secured using T-flat bars; the stress of the membrane being adjusted using a handle; the foot is positioned on the membrane; an image is taken; and the insole is subjected to double-sided machining on the basis of the image of the surface provided in STL format, with the aid of a securing device that enables the pieces to be rotated up to | 12-22-2011 |
Angel Perez Trujillo, Barcelona ES
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20080266688 | Folding Mechanism for Exterior Rear-View Mirrors in Automotive Vehicles - The present invention relates to a folding mechanism for exterior rear-view mirrors in an automotive vehicle, comprising a housing integral with a mirror-carrying casing, and an actuated ring acting as an axis of rotation of the mentioned casing with respect to a support chassis fixed to the vehicle, the ring being provided with first positional fixing means susceptible to coupling the mentioned ring to the support chassis and with second positional fixing means which, in collaboration with a stop element integral with the housing and loaded by un elastic member, limit the rotation of the mentioned casing around the ring and according to one rotating direction, all this with the stop element and the elastic member being integrated in a single piece with elastic properties. | 10-30-2008 |
Angel Pipitone, N. Massapequa, NY US
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20110265251 | METHOD AND APPARATUS FOR ADJOINING A PAIR OF SOCKS - The present invention relates to a method of adjoining a pair of socks comprising the steps of: attaching a button to a first sock of the pair of socks; creating an insertion mechanism in a second sock of the pair of socks; and inserting the button into the insertion mechanism to join the first sock to the second sock. The insertion mechanism may include an open loop. The present invention further relates to a pair of adjoining socks comprising: a button on a first sock; and a mechanism for inserting the button on a second sock. The mechanism for inserting may include an open loop. | 11-03-2011 |
Angel Pons Ferre, Barcelona ES
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20110092782 | MULTIFUNCTIONAL EQUIPMENT FOR MEASURING VITAL DATA, PROVIDED WITH A CENTRALISED DATA PROCESSING SYSTEM - The invention relates to multifunctional equipment intended for measuring the vital data of a user, such as weight, height, body fat index and blood pressure. For this purpose, the equipment includes a platform for supporting the user, a device for emitting an ultrasonic beam and a receiver for receiving the reflected beam, a device for measuring blood pressure, a keyboard and screens for providing help and displaying the results, as well as payment means. The equipment also includes a digital fingerprint reader intended for the unequivocal identification of a user, together with an internal data processing device provided with inlet/outlet ports for connecting same to a computer associated with the equipment or to a remote computer forming a central database which can be accessed both from the first computer associated with the equipment and from other external computers over the Internet. | 04-21-2011 |
Angel Porgador, Lehavim IL
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20080279878 | Compositions of Hsp60 Peptides and Viral Antigens for Vaccination and Diagnosis - The present invention provides improved vaccines comprising an isolated viral antigenic peptide and a synthetic peptide derived from a T cell epitope of HSP60. The invention includes mixtures where the peptide serves as an adjuvant as well as conjugates where the peptide is covalently linked to the viral antigen. The known synthetic peptide carrier, p458, provides significantly improved immunogenicity for synthetic viral epitopes and analogs. Ec27 is a novel peptide derived from HSP60 which increases the immunogenicity substantially of the viral antigen both as a mixture or a covalent conjugate. Some of the isolated viral epitopes are novel and are claimed for diagnostic as well as therapeutic or prophylactic uses. | 11-13-2008 |
20100047169 | NK Cell Receptor Conjugates for Treating Malignancies - The present invention relates generally to compositions useful in therapies involving the selective destruction of tumor cells in vivo. In particular, this invention relates to a conjugate which comprises a target recognition segment and an active cytotoxic segment. The target recognition segment comprises a receptor specific to NK cells, wherein the receptor binds to a cellular ligand expressed on the surface of a tumor cell, and the active segment comprises an agent capable of exerting a cytotoxic effect on the tumor cell. The target recognition segment derived form the natural killer receptor NKp30 has been found to be particularly effective in vivo. | 02-25-2010 |
20110256165 | COMPOSITIONS OF HSP60 PEPTIDES AND VIRAL ANTIGENS FOR VACCINATION AND DIAGNOSIS - The present invention provides improved vaccines comprising an isolated viral antigenic peptide and a synthetic peptide derived from a T cell epitope of HSP60. The invention includes mixtures where the peptide serves as an adjuvant as well as conjugates where the peptide is covalently linked to the viral antigen. The known synthetic peptide carrier, p458, provides significantly improved immunogenicity for synthetic viral epitopes and analogs. Ec27 is a novel peptide derived from HSP60 which increases the immunogenicity substantially of the viral antigen both as a mixture or a covalent conjugate. Some of the isolated viral epitopes are novel and are claimed for diagnostic as well as therapeutic or prophylactic uses. | 10-20-2011 |
20120076753 | USE OF NKP46 FOR PREVENTING DIABETES - The invention relates to use of the natural cytotoxicity receptor NKp46 for preventing and treating diabetes, including type I diabetes (TID) and type 2 diabetes. In particular, the invention provides compositions comprising a fragment of the extracellular region of NKp46 for preventing the onset and progression of diabetes. | 03-29-2012 |
20130280209 | METHOD FOR TREATING TYPE 1 DIABETES - The invention relates to use of the natural cytotoxicity receptor NKp46 for preventing and treating diabetes, including type I diabetes (TID) and type 2 diabetes. In particular, the invention provides compositions comprising a fragment of the extracellular region of NKp46 for preventing the onset and progression of diabetes. | 10-24-2013 |
20140120126 | COMPOSITIONS OF HSP60 PEPTIDES AND VIRAL ANTIGENS FOR VACCINATION AND DIAGNOSIS - The present invention provides improved vaccines comprising an isolated viral antigenic peptide and a synthetic peptide derived from a T cell epitope of HSP60. The invention includes mixtures where the peptide serves as an adjuvant as well as conjugates where the peptide is covalently linked to the viral antigen. The known synthetic peptide carrier, p458, provides significantly improved immunogenicity for synthetic viral epitopes and analogs. Ec27 is a novel peptide derived from HSP60 which increases the immunogenicity substantially of the viral antigen both as a mixture or a covalent conjugate. Some of the isolated viral epitopes are novel and are claimed for diagnostic as well as therapeutic or prophylactic uses. | 05-01-2014 |
20140328824 | Diagnostic and Therapeutic Methods and Their Application in Amyotrophic Lateral Sclerosis (ALS) - The present invention provides a method of treating, delaying the onset, delaying progression of, reducing the incidence of or reducing the severity of amyotrophic lateral sclerosis in a subject, the method comprising administering to a subject an agent, which interferes with IgG-A2BG2 expression, IgG-A2BG2 function or IgG-A2BG2 interaction with CD16 in said subject. | 11-06-2014 |
20150105334 | PEPTIDES DERIVED FROM NKP44 - The invention provides specific peptides derived from the cytotoxicity receptor NKp44 useful for preventing and treating serious diseases including in particular cancer. The invention further relates to compositions comprising a fragment of the extracellular region of NKp44 for preventing or treating cancer. | 04-16-2015 |
Angel Postigo Rodriguez, Getafe ES
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20120132749 | TAIL-CONE OF AN AIRCRAFT WITH MOVABLE FAIRING - A tail-cone of an aircraft includes a skin provided with a movable fairing which, by a swing articulated mechanism, is supported on the skin in order to allow the opening/closing of the movable fairing and gain access to the inside of the tail-cone. The tail-cone includes actuators for operating the swing articulated mechanism in order to permit the automatic opening and closing of the movable fairing to be carried out. | 05-31-2012 |
Angel Postigo Rodriguez, Madrid ES
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20100059627 | Aircraft with a Rear Fuselage Protection Shield - The invention relates to an aircraft with a protection shield for the rear composite material, fuselage | 03-11-2010 |
Angel Postigo Rodríguez, Madrid ES
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20120074260 | REAR FUSELAGE OF AN AIRCRAFT - Rear fuselage of an aircraft comprising a tail cone end and a rest of the real fuselage whereby the tail cone end is attached to the rest of the rear fuselage by means of an attachment system comprising two upper lugs, two lower lugs and a detachable balancer fitting. The balancer fitting is an adjustable fitting, being locked in a Z and Y directions of a Cartesian axis and being movable along an X direction of the Cartesian axis providing guidance for the tail cone end and the rest of the rear fuselage. | 03-29-2012 |
Angel Regalado Sanchez, Madrid ES
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20110270439 | AUTOMATIC APPARATUS FOR SELECTING, DISPENSING AND COLLECTING RE-USABLE ITEMS - The present invention relates to an automatic apparatus for selecting, dispensing and collecting re-usable items comprising at least one user interface comprising a computer for selecting re-usable items and at least one device for dispensing and/or collecting re-usable items, a storage system for storing the re-usable items, a transportation system for transferring the re-usable items between the storage system and the at least one device for dispensing and/or collecting re-usable items, wherein the re-usable items are stored and transferred within the apparatus by means of carriers but dispensed and/or collected carrier-less. | 11-03-2011 |
Angel Rivas Casado, Vizcaya ES
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20120246599 | INTUITIVE DATA VISUALIZATION METHOD - A computer software program, method and system has a data visualization scheme in the form of plural identifiable virtual characters in a familiar virtual environment that is relevant for the characters and in which the characters act in the context of the environment and in a manner that is indicative of the data or data set portrayed by each character. From the actions and interactions of the virtual characters in the context of the virtual environment, information about the nature and interactions of the data and data sets is quickly and intuitively appreciated by a viewer. | 09-27-2012 |
Angel Rodriguez Montes, Ordino ES
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20110075316 | SYSTEM FOR RECOVERING AND USING THE ELECTROSTATIC CHARGE GENERATED BY LIGHTNING - A system for the recovery and use of the electrostatic charge present in the atmosphere during storms generated by lightning, transforming natural energy into electrical energy useful for consumption, and providing the necessary protection for lives and property against electro-atmospheric phenomena, has an ecological lightning conductor, an electrical conductor connected by one end to the low-frequency electrode of the lightning conductor, and an enhanced intelligent earth wire, whereto the conductor is joined by its other end. The conductor includes a series of probes and magnetic field detectors which will send information to the microprocessor and from there to the mainframe computer. The control device allows regulation of the earth resistance, thereby generating more or less charge, diverting the energy to the accumulators or to earth through dissipator electrodes. | 03-31-2011 |
Angel Ruiz Arranz, Barcelona ES
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20110065170 | DEVICE FOR THE PRESERVATION OF A HEPATIC GRAFT IN NORMOTHERMIA - The invention relates to a device for the preservation of a hepatic graft in normothermia comprising a receptacle in which said hepatic graft is housed in a preservation solution, an arterial perfusion circuit, a portal perfusion circuit, at least one flow sensor of a perfusion circuit, and at least one pressure sensor of a perfusion circuit. For the purpose of increasing the preservation of the hepatic graft, the preservation device additionally comprises an arterial oxygenator connected to the arterial perfusion circuit, a portal oxygenator connected to the portal perfusion circuit, at least one arterial perfusion pump, at least one portal perfusion pump, a temperature exchange module configured to maintain the temperature inside the receptacle in normothermia, and a pressure and flow control device. | 03-17-2011 |
Angel Sanjurjo, San Jose, CA US
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20090253252 | SUBSTRATES FOR SILICON SOLAR CELLS AND METHODS OF PRODUCING THE SAME - Aspects of the invention include methods for depositing silicon on a substrate. In certain embodiments, the methods include exposing a substrate containing silicon to a halogenated silane in a manner sufficient to deposit the silicon on the substrate. In certain embodiments, the method includes providing a substrate, one or more sources of gas, and a reaction vessel that is in fluid communication with the substrate and the one or more sources of gas. In certain embodiments, the substrate is a low or metallurgical grade silicon which may be subjected to a purification process. In certain embodiments, the reaction vessel is a particle bed reaction vessel that includes a moving bed, such as a fluidized bed which contains silicon and the gas includes a halide. | 10-08-2009 |
20090291235 | MULTIARC DISCHARGE MOVING BED REACTOR SYSTEM - A moving bed reactor system is provided. The system comprises at least one gas inlet, a distributor, a temperature control, a plurality of electrodes, and a spark control circuit. The spark control circuit drives the electrodes and generates a multi-arc discharge when the system is loaded with particles and a gas at approximately atmospheric pressure or greater is being pumped through the system. The multi-arc discharge is useful to create activated species which may improve the rate of a chemical reaction taking place in the moving bed reactor system. | 11-26-2009 |
20100056353 | METHOD AND SYSTEM FOR PRODUCING FLUORIDE GAS AND FLUORINE-DOPED GLASS OR CERAMICS - The present invention relates generally to production of a fluoride gas and equivalents thereof, and fluorine-doped sodium silicate glass, glass ceramics, vitro ceramics and equivalents thereof. In one embodiment, the method includes providing a salt and an oxide in a reactor, heating the reactor to produce a vapor and the vitro ceramic and removing the vapor. | 03-04-2010 |
20100075456 | METHOD AND SYSTEM FOR PRODUCING FILMS FOR DEVICES SUCH AS SOLAR CELLS FROM SEMICONDUCTOR POWDERS OR DUST - The present invention relates generally to production of photoelectric grade films or cells from semiconductor powders or dust. In one embodiment, the present invention provides a method for producing a photoelectric grade film from a semiconductor powder. The method includes providing a substrate, coating the substrate with a layer of the semiconductor powder and moving the substrate with the layer of the semiconductor powder under an energy source at a predefined rate, wherein the predefined rate is sufficient to melt the semiconductor powder by the energy source and to cool the substrate such that substantially all impurities are moved to an edge of the substrate. | 03-25-2010 |
20100103765 | LIQUID INJECTOR FOR SILICON PRODUCTION - The present invention relates generally to a liquid injector for silicon production. In one embodiment, the injector includes a tube having at least one opening at a first end of said tube, a moveable sealing means disposed inside the tube for sealing the at least one opening and a heating means coupled to the tube for controlling a temperature of a liquid exiting the tube through the at least one opening. | 04-29-2010 |
20110008235 | METHOD FOR MODERATE TEMPERATURE REUTILIZATION OF IONIC HALIDES - In one embodiment, the present invention relates generally to a method for reutilizing ionic halides in a production of an elemental material. In one embodiment, the method includes reacting a mixture of an ionic halide, at least one of: an oxide, suboxide or an oxyhalide of an element to be produced and an aqueous acid solution at moderate temperature to form a complex precursor salt and a salt, forming a precursor halide from the complex precursor salt, reducing the precursor halide into the element to be produced and the ionic halide and returning the ionic halide into the mixture of the reacting step. | 01-13-2011 |
20110038779 | MULTI-STAGE SYSTEM FOR REACTION AND MELT COALESCENCE AND SEPARATION - In one embodiment, the present invention relates generally to a multi-stage system for performing melt coalescence and separation, the multi-stage system. In one embodiment, the multi-stage system includes a first container for mixing a powder with a salt, the first container having an opening, a heating means coupled to the first container for heating the first container and a second container coupled to the first container. | 02-17-2011 |
20110300049 | METHOD FOR SEPARATION OF COMPONENTS FROM A REACTION MIXTURE VIA A CONCENTRATED ACID - In one embodiment, the present disclosure relates generally to a method for recovering an element from a mixture of the element with an ionic halide. In one embodiment, the method includes treating the mixture of the element and the ionic halide with an acidic solution to dissolve the ionic halide, wherein the acidic solution comprises water and an acid and has a pH of less than 1.0 and removing the element from an aqueous solution that results after the treating step. | 12-08-2011 |
20120009116 | HIGH TEMPERATURE DECOMPOSITION OF COMPLEX PRECURSOR SALTS IN A MOLTEN SALT - In one embodiment, the present disclosure relates generally to a method for thermally decomposing a complex precursor salt. In one embodiment, the method includes heating a salt in a reactor until a molten salt is formed, adding the complex precursor salt to the molten salt in the reactor and removing a volatile precursor halide formed from thermal decomposition of the complex precursor salt from the reactor. | 01-12-2012 |
20120325088 | FALLING MICROBEAD COUNTER-FLOW PROCESS FOR SEPARATING GAS MIXTURES - A method and reactor for removing a component from a gas stream is provided. In one embodiment, the method includes providing the gas stream containing the component that is to be removed and adsorbing the component out of the gas stream as the gas stream rises via microbeads of a sorbent falling down an adsorber section of a reactor. | 12-27-2012 |
20130150265 | CHEMICAL SYNTHESIS USING UP-CONVERTING PHOSPHOR TECHNOLOGY AND HIGH SPEED FLOW CYTOMETRY - The invention offers the ability to rapidly synthesize multiple chemical compounds, particularly polymers of varying sequences, in parallel on the surfaces of carrier beads. Tinvention involves attaching up-converting phosphors (UCP's) to beads to create up-converting phosphor-loaded beads (UCP-loaded beads) with unique spectral characteristics. Using a dynamic sorting architecture each bead is cataloged based on its spectral characteristics, assigned a compound or polymer to be synthesized, and subjected to multiple rounds of sorting by a flow cytometer, wherein each round sorts the bead to an appropriate bin for a selected chemical reaction, such as the attachment of a monomeric subunit of the polymer sequence. | 06-13-2013 |
20150246310 | Rate enhancement of CO2 absorption in aqueous potassium carbonate solutions by an ammonia-based catalyst - The technical field of the invention is CO | 09-03-2015 |
20150258487 | Monolithic Natural Gas Storage Delivery System Based on Sorbents - The invention provides methods for producing a strong, light, sorbent-based storage/dispenser system for gases and fuels. The system comprises a porous monolithic material with an adherent strong impervious skin that is capable of storing a gas under pressure in a safe and usable manner. | 09-17-2015 |
20150330676 | Hybrid Indirect/Direct Contactor for Thermal Management of Counter-Current Processes - The invention relates to contactors suitable for use, for example, in manufacturing and chemical refinement processes. In an aspect is a hybrid indirect/direct contactor for thermal management of counter-current processes, the contactor comprising a vertical reactor column, an array of interconnected heat transfer tubes within the reactor column, and a plurality of stream path diverters, wherein the tubes and diverters are configured to block all straight-line paths from the top to bottom ends of the reactor column. | 11-19-2015 |
Angel Santanach Delisau, Barcelona ES
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20110159086 | PHARMACEUTICAL FORMULATION COMPRISING A CB1-RECEPTOR COMPOUND IN A SOLID SOLUTION AND/OR SOLID DISPERSION - The present invention relates to a pharmaceutical formulation comprising 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-N-(cis-2,6-dimethylpiperidin-1-yl)-4-methyl-4,5-dihydro-1H-pyrazole-3-carboxamide as racemate or (S)-enantiomer or mixtures thereof in a solid solution and/or solid dispersion. | 06-30-2011 |
20120231074 | PHARMACEUTICAL SOLID DOSAGE FORM - The present invention is directed to a solid dosage form comprising (i) a core comprising a benzimidazole; (ii) a separating layer comprising a water soluble polymer and glyceryl monostearate; and (iii) an enteric coating. | 09-13-2012 |
Angel Sedano Garcia, Sevilla ES
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20110062707 | SEALED MECHANICAL CONNECTION BETWEEN GLASS AND METAL FOR RECEIVER TUBES USED IN SOLAR PLANTS - The invention relates to a sealed mechanical connection between glass and metal for receiver tubes used in solar plants of the type using a heat-transfer fluid, which uses a mechanical force in order to establish the seal between the inner metal tubes and the outer glass tubes, between which tubes a high vacuum is established in order to prevent heat losses. According to the invention, a flexible, deformable metal joint is used for the above-mentioned seal, which joint, when duly compressed, adapts to the corresponding surfaces of the tubes to be sealed, thereby establishing the seal between the respective tubes. In addition, the invention can include a continuous system for maintaining the necessary vacuum between both types of tubes. | 03-17-2011 |
Angel Smith, Pepperell, MA US
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20110270808 | Systems and Methods for Discovering Synonymous Elements Using Context Over Multiple Similar Addresses - A clustering-based approach to data standardization is provided. Certain embodiments take as input a plurality of addresses, identify one or more features of the addresses, cluster the addresses based on the one or more features, utilize the cluster(s) to provide a data-based context useful in identifying one or more synonyms for elements contained in the address(es), and standardize the address(es) to an acceptable format, with one or more synonyms and/or other elements being added to or taken away from the input address(es) as part of the standardization process. | 11-03-2011 |
Angel Suarez Del Moral, Maono (cantabria) ES
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20100135804 | WIND-POWERED GENERATOR - A generator with arms forming the shape of a star and with each of them having an articulated blade capable of being fixed to the arm and being fastened temporarily to it by means of a voidable retaining element, which is moveable between a retaining position and a released position of the corresponding blade. | 06-03-2010 |
Angel Sustaeta, Austin, TX US
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20090204234 | SYSTEM AND METHOD FOR DYNAMIC MULTI-OBJECTIVE OPTIMIZATION OF MACHINE SELECTION, INTEGRATION AND UTILIZATION - The invention provides control systems and methodologies for controlling a process having computer-controlled equipment, which provide for optimized process performance according to one or more performance criteria, such as efficiency, component life expectancy, safety, emissions, noise, vibration, operational cost, or the like. More particularly, the subject invention provides for employing machine diagnostic and/or prognostic information in connection with optimizing an overall business operation over a time horizon. | 08-13-2009 |
20090204237 | SYSTEM AND METHOD FOR DYNAMIC MULTI-OBJECTIVE OPTIMIZATION OF MACHINE SELECTION, INTEGRATION AND UTILIZATION - The invention provides control systems and methodologies for controlling a process having computer-controlled equipment, which provide for optimized process performance according to one or more performance criteria, such as efficiency, component life expectancy, safety, emissions, noise, vibration, operational cost, or the like. More particularly, the subject invention provides for employing machine diagnostic and/or prognostic information in connection with optimizing an overall business operation over a time horizon. | 08-13-2009 |
20090204245 | SYSTEM AND METHOD FOR DYNAMIC MULTI-OBJECTIVE OPTIMIZATION OF MACHINE SELECTION, INTEGRATION AND UTILIZATION - The invention provides control systems and methodologies for controlling a process having computer-controlled equipment, which provide for optimized process performance according to one or more performance criteria, such as efficiency, component life expectancy, safety, emissions, noise, vibration, operational cost, or the like. More particularly, the subject invention provides for employing machine diagnostic and/or prognostic information in connection with optimizing an overall business operation over a time horizon. | 08-13-2009 |
20090204267 | SYSTEM AND METHOD FOR DYNAMIC MULTI-OBJECTIVE OPTIMIZATION OF MACHINE SELECTION, INTEGRATION AND UTILIZATION - The invention provides control systems and methodologies for controlling a process having computer-controlled equipment, which provide for optimized process performance according to one or more performance criteria, such as efficiency, component life expectancy, safety, emissions, noise, vibration, operational cost, or the like. More particularly, the subject invention provides for employing machine diagnostic and/or prognostic information in connection with optimizing an overall business operation over a time horizon. | 08-13-2009 |
20090210081 | SYSTEM AND METHOD FOR DYNAMIC MULTI-OBJECTIVE OPTIMIZATION OF MACHINE SELECTION, INTEGRATION AND UTILIZATION - The invention provides control systems and methodologies for controlling a process having computer-controlled equipment, which provide for optimized process performance according to one or more performance criteria, such as efficiency, component life expectancy, safety, emissions, noise, vibration, operational cost, or the like. More particularly, the subject invention provides for employing machine diagnostic and/or prognostic information in connection with optimizing an overall business operation over a time horizon. | 08-20-2009 |
20110172838 | INDUSTRIAL CONTROL ENERGY OBJECT - An energy object extension to an industrial protocol having a comprehensive suite of attributes, messages and services utilized for the monitoring and control of energy consuming or producing resources by a manufacturing automation application is provided. The energy object includes an identifier associated with an energy resource that is associated with a manufacturing automation application and an energy type associated with the energy resource. This includes a measurement characteristic associated with the energy resource to facilitate energy management by the manufacturing automation application. | 07-14-2011 |
20130096727 | INDUSTRIAL CONTROL ENERGY OBJECT - An energy object extension to an industrial protocol having a comprehensive suite of attributes, messages and services utilized for the monitoring and control of energy consuming or producing resources by a manufacturing automation application is provided. The energy object includes an identifier associated with an energy resource that is associated with a manufacturing automation application and an energy type associated with the energy resource. This includes a measurement characteristic associated with the energy resource to facilitate energy management by the manufacturing automation application. | 04-18-2013 |
20140257586 | INDUSTRIAL CONTROL ENERGY OBJECT - An energy object extension to an industrial protocol having a comprehensive suite of attributes, messages and services utilized for the monitoring and control of energy consuming or producing resources by a manufacturing automation application is provided. The energy object includes an identifier associated with an energy resource that is associated with a manufacturing automation application and an energy type associated with the energy resource. This includes a measurement characteristic associated with the energy resource to facilitate energy management by the manufacturing automation application. | 09-11-2014 |
Angel Tokmakchiev, Sofia BG
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20100153941 | FLEXIBLE CONTENT UPDATE VIA DEPLOYMENT ORDER TEMPLATE - Described herein are a system and a method for multi-functional software solution updates, which use a deployment order template. The deployment order template contains a plurality of action instructions and deployable component definitions. The method calculates an individual deployment sequence for each specific update scenario according to a plurality of deployable components available for update and the deployment order template. If some deployable components require as a prerequisite the execution of some steps, these steps are executed prior to the update of the depending components. If some deployable components require the execution of some steps after they have been updated, these steps are executed after the update occurs. If some of the deployable components specified in the deployment order template are not available for update, the deployment sequence skips the steps associated with these deployable component. | 06-17-2010 |
Angel Torrado, Madrid ES
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20120073890 | Multi-Worm Circle Drive Gearbox - A work vehicle comprises a frame, a circle gear mounted to the frame to rotate relative thereto, a moldboard coupled to the circle gear to rotate therewith, and a circle drive gearbox comprising gearing, a first worm, and a second worm, the gearing meshing with the circle gear, the first and second worms meshing with the gearing. | 03-29-2012 |
Angel Ve Lasco, Voisins Le Bretonneux FR
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20110120792 | AIR GUIDE DEVICE FOR FRONT FACE STRUCTURE OF VEHICLE - The invention relates to a device for guiding air from a vehicle front surface structure including heat exchangers ( | 05-26-2011 |
20110155491 | SIDE CONVERGER FOR VEHICLE FRONT FACE STRUCTURE, CORRESPONDING FRONT FACE STRUCTURE, AND METHOD FOR ASSEMBLING SUCH A STRUCTURE - A side diffuser for a vehicle front surface structure, the vehicle front surface structure, and a method for assembling such a structure. The side diffuser guides air entering through air inlets from bumpers of the vehicle to heat exchangers located in front of the engine. The diffuser includes a plate, the back edge of which supports the heat exchangers and the front edge of which supports the bumpers and includes a recess capable of receiving the front crosspiece end of the vehicle. The back side of the diffuser includes: a pivoting axis capable of engaging with a corresponding receiving part provided on the heat exchangers, and an attaching part capable of engaging with a corresponding attaching part provided on the heat exchangers after one rotation of the side diffuser around pivoting axis. | 06-30-2011 |
Angel Yanguas-Gil, Naperville, IL US
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20120213946 | Doping Control by ALD Surface Functionalization - Systems and methods for producing a material of desired thickness. Deposition techniques such as atomic layer deposition are alter to control the thickness of deposited material. A funtionalization species inhibits the deposition reaction. | 08-23-2012 |
20140004381 | ENHANCED MATERIALS AND INTERFACIAL PERFORMANCE VIA INFILTRATION | 01-02-2014 |
20150031157 | METHOD AND SYSTEM FOR CONTINUOUS ATOMIC LAYER DEPOSITION - A system and method for continuous atomic layer deposition. The system and method includes a housing, a moving bed which passes through the housing, a plurality of precursor gases and associated input ports and the amount of precursor gases, position of the input ports, and relative velocity of the moving bed and carrier gases enabling exhaustion of the precursor gases at available reaction sites. | 01-29-2015 |
Angel Yanguas-Gil, Urbana, IL US
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20100048029 | Surface Preparation for Thin Film Growth by Enhanced Nucleation - Various processes and related systems are provided for making structures on substrate surfaces. Disclosed are methods of making a structure supported by a substrate by providing a substrate having a receiving surface and exposing at least a portion of the receiving surface to output from a remote plasma of an inert gas. The remote plasma has an energy low enough to substantially avoid etching or sputtering of the receiving surface but sufficient to generate a treated receiving surface. The treated surface is contacted with a deposition gas, thereby making the structure supported by the substrate. | 02-25-2010 |
20110200762 | Surface Preparation for Thin Film Growth by Enhanced Nucleation - Various processes and related systems are provided for making structures on substrate surfaces. Disclosed are methods of making a structure supported by a substrate by providing a substrate having a receiving surface and exposing at least a portion of the receiving surface to output from a remote plasma of an inert gas. The remote plasma has an energy low enough to substantially avoid etching or sputtering of the receiving surface but sufficient to generate a treated receiving surface. The treated surface is contacted with a deposition gas, thereby making the structure supported by the substrate. | 08-18-2011 |
Angel Zamarreño, Eugui ES
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20120010078 | Metabolic and nutritional activator for plants - This invention relates to a new formulation activating the absorption of mineral nutrients by plants. Consequently, it has also an effect on the metabolization of these mineral compounds by the plant. These formulations that have been discovered with this property activating nutrient absorption have as main component the compounds represented by general formula 1 | 01-12-2012 |
Ángel Arenal Maíz, Madrid ES
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20130069945 | METHOD FOR DISPLAYING THE INFORMATION CONTAINED IN THREE-DIMENSIONAL IMAGES OF THE HEART - This invention describes a method, the starting point of which is a three-dimensional image of the heart. A region of interest is defined on said image. Moreover, the surface which will be represented in the display in the form of a three-dimensional polygon mesh is defined. Each vertex of the mesh is associated with a function which assigns weights to each element in the region of interest. Display parameters are assigned to the vertices using said functions together with the intensity values of the elements in the region of interest. Said parameters are used to generate the interactive display of the surface. One application of the method would be the use thereof to help to characterize the myocardial substrate of ventricular tachycardia in patients with ischemic heart disease and to guide ablation procedures for correcting said tachycardia. | 03-21-2013 |
Ángel Arenal Maíz, Madrid ES
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20130069945 | METHOD FOR DISPLAYING THE INFORMATION CONTAINED IN THREE-DIMENSIONAL IMAGES OF THE HEART - This invention describes a method, the starting point of which is a three-dimensional image of the heart. A region of interest is defined on said image. Moreover, the surface which will be represented in the display in the form of a three-dimensional polygon mesh is defined. Each vertex of the mesh is associated with a function which assigns weights to each element in the region of interest. Display parameters are assigned to the vertices using said functions together with the intensity values of the elements in the region of interest. Said parameters are used to generate the interactive display of the surface. One application of the method would be the use thereof to help to characterize the myocardial substrate of ventricular tachycardia in patients with ischemic heart disease and to guide ablation procedures for correcting said tachycardia. | 03-21-2013 |
Ángel Arévalo Martín, Toledo ES
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20120015945 | USE OF CB1 ANTAGONISTS AND/OR INVERSE AGONISTS FOR THE PREPARATION OF DRUGS THAT INCREASE MOTOR NEURON EXCITABILITY - Use of a CB1 receptor antagonist and/or inverse agonist, preferably rimonabant, for the preparation of drugs useful for increasing motor neuron excitability in the cerebral cortex and/or in the brain stem and/or at the spinal level, as well as a method for increasing motor neuron excitability through the administration of a CB1 antagonist/inverse agonist receptors, and to the use of a pharmaceutical composition which comprises a CB1 receptor antagonist and/or inverse agonist, preferably rimonabant, for increasing motor neuron excitability in the cerebral cortex and/or in the brain stem and/or at the spinal level. | 01-19-2012 |
Ángel Cantero Camacho, Ciudad Real ES
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20160108024 | BILATERALLY-SUBSTITUTED TRICYCLIC COMPOUNDS FOR THE TREATMENT OF HUMAN IMMUNODEFICIENCY VIRUS TYPE-1 (HIV-1) INFECTION AND OTHER DISEASES - The invention relates to novel bilaterally-substituted tricyclic compounds and pharmaceutical compositions containing them, for use as medicaments. | 04-21-2016 |
Ángel Cantin Sanz, Valencia ES
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20130046123 | ITQ-47 MATERIAL, METHOD FOR OBTAINING SAME AND USE THEREOF - The present invention relates to a micro-porous crystalline material that is isostructural with the mineral known as boggsite and to a method for preparing same, said material having composition x X | 02-21-2013 |
Ángel Chamadoira Gández, Vigo-Pontevedra ES
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20140041644 | HEAT EXCHANGER FOR COOLING EXHAUST GAS - The present invention relates to a heat exchanger for cooling a gas which can mainly be applied in EGR systems with a floating core. The differences in temperature achieved during operation of the casing and the core of gas ducts housed therein give rise to degrees of expansion which are also different. If the ends of both components were fixed to each other, stresses which would cause the breakage thereof would occur. The common solution applied is to leave one of the ends of the core of ducts floating, i.e., with capacity for longitudinal displacement with respect to the casing to prevent the occurrence of stresses. The floating end of the core has an attachment by means of O-ring gaskets. The O-ring gaskets are made of an elastomer that cannot reach very high temperatures, hence in the state of the art the floating attachment is on the side where the already cooled gas exits. The invention is characterized by a special manner of attaching the end where the core is floating and the casing so as to allow the end where the hot gas enters to be the end where the attachment is a floating attachment. | 02-13-2014 |
Ángel Chamadoira Gomez, Vigo-Pontevedra ES
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20140041832 | DEVICE FOR REDUCING THE VIBRATIONS OF A TUBE BUNDLE OF A HEAT EXCHANGER INSIDE ITS SHELL - The present invention relates to a device for reducing the vibrations of a tube bundle of a heat exchanger inside its shell, wherein this device allows a secure and quick insertion after the bundle has been manufactured. This easy insertion after manufacturing the bundle allows the high temperatures to which the bundle is subjected for the attachment by means of brazing to not affect the properties of the device, particularly the elasticity achieved by means of tempering, for example. | 02-13-2014 |
Ángel Chamorro Sánchez, Barcelona ES
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20120108532 | PHARMACEUTICAL COMPOSITION FOR NEUROPROTECTIVE TREATMENT IN PATIENTS WITH ICTUS COMPRISING CITICOLINE AND URIC ACID - A pharmaceutical composition comprised of uric acid and citicoline is for the neuroprotective treatment of patients with ictus. | 05-03-2012 |
Ángel Cuesta-Martínez, Madrid ES
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20140348826 | ENGINEERING MULTIFUNCTIONAL AND MULTIVALENT MOLECULES WITH COLLAGEN XV TRIMERIZATION DOMAIN - The invention relates generally to a new trimerization domain useful for developing multifunctional and multivalent complexes. Particularly, the invention relates to the design of trimeric polypeptide complexes using polypeptide structural elements derived from the collagen XV protein, and their use in diagnostic and therapeutic systems in vivo and in vitro. The invention also relates to nucleic acids and vectors useful for producing said trimeric complexes. | 11-27-2014 |
20150139991 | GENERATION OF MULTIFUNCTIONAL AND MULTIVALENT POLYPEPTIDE COMPLEXES WITH COLLAGEN XVIII TRIMERIZATION DOMAIN - The invention relates to the design of trimeric polypeptide complexes using polypeptide structural elements derived from the collagen XVIII protein, and their use in diagnostic and therapeutic systems in vivo and in vitro. The invention also relates to nucleic acids and vectors useful for producing said trimeric complexes. | 05-21-2015 |
Ángel De Marcos Serrano, Getafe (madrid) ES
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20110119886 | METHOD FOR DESIGNING AND MANUFACTURING MODEL PIECES OF VARIABLE CONFIGURATION - It is applied in those processes in which it is required to modify the configuration of a first piece ( | 05-26-2011 |
Ángel Lozano Sicilia, Madrid ES
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20120015945 | USE OF CB1 ANTAGONISTS AND/OR INVERSE AGONISTS FOR THE PREPARATION OF DRUGS THAT INCREASE MOTOR NEURON EXCITABILITY - Use of a CB1 receptor antagonist and/or inverse agonist, preferably rimonabant, for the preparation of drugs useful for increasing motor neuron excitability in the cerebral cortex and/or in the brain stem and/or at the spinal level, as well as a method for increasing motor neuron excitability through the administration of a CB1 antagonist/inverse agonist receptors, and to the use of a pharmaceutical composition which comprises a CB1 receptor antagonist and/or inverse agonist, preferably rimonabant, for increasing motor neuron excitability in the cerebral cortex and/or in the brain stem and/or at the spinal level. | 01-19-2012 |
Ángel Martínez-Garrido Martínez, Paterna ES
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20120136237 | COMPACT, HYBRID AND INTEGRATED GAMMA/RF SYSTEM USED TO FORM SIMULTANEOUS PET OR SPECT AND MR IMAGES - The GAMMA/RF compact, hybrid and integrated system for PET-SPECT/MR simultaneous imaging of the invention comprises a GAMMA/RF device that integrates an RF coil, of the type used in conventional MR systems, with GAMMA radiation detector modules of the type used in PET or SPECT systems, so that combined PET or SPECT and MR images are obtained. | 05-31-2012 |
Ángel Mérida Berlanga, Pamplona ES
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20120102597 | METHOD FOR THE PRODUCTION OF TRANSGENIC PLANTS HAVING HIGH STARCH AND BIOMASS CONTENT AND YIELD - Process for the production of transgenic plants that have high content and yield of starch and biomass. The starch synthases (SSs) in plants (including SSIV) and glycogen synthase (GlgA) in bacteria catalyse the transfer of the glucosidic part of the ADP-Glucose molecule (the activated donor of glucose) to a pre-existing α(1, 4)-glucan. However, in contrast to the other SSs, SSIV is able to add glucose units to maltotriose. Also, in contrast to other soluble SSs, SSIV is bound to the starch granule. This invention describes for the first time how to obtain plants that have high levels and yields of starch and biomass as a consequence of the expression of genes coding for SSIV. | 04-26-2012 |
Ángel Merlos Domingo, Barcelona ES
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20100193378 | IMPEDIMETRIC SENSOR AND APPLICATIONS THEREOF - The invention relates to a highly sensitive impedimetric sensor in which the highly conductive electrodes are separated by a barrier of insulating material. Said sensor is used to determine directly the presence of analytes in a biological sample of human, veterinary or environmental origin. | 08-05-2010 |
Ángel Merlos Domingo, Barcelona ES
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20100193378 | IMPEDIMETRIC SENSOR AND APPLICATIONS THEREOF - The invention relates to a highly sensitive impedimetric sensor in which the highly conductive electrodes are separated by a barrier of insulating material. Said sensor is used to determine directly the presence of analytes in a biological sample of human, veterinary or environmental origin. | 08-05-2010 |
Ángel Messeguer Peypoch, Barcelona ES
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20100247587 | PIGMENTATION-REGULATING COMPOUNDS - The present invention relates to compounds of general formula (I): | 09-30-2010 |
20110160189 | COMPOUND THAT CAN INHIBIT UBC13-UEV INTERACTIONS, PHARMACEUTICAL COMPOSITIONS AND THERAPEUTIC USES - The invention relates to a compound (I) wherein R is a heterocyclyl radical; R | 06-30-2011 |
20140005247 | CHROMENE DERIVATIVES | 01-02-2014 |
Ángel Messeguer Peypoch, Barcelona ES
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20100247587 | PIGMENTATION-REGULATING COMPOUNDS - The present invention relates to compounds of general formula (I): | 09-30-2010 |
Ángel Messeguer Pyepoch, Barcelona ES
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20120122868 | APAF-1 INHIBITOR COMPOUNDS - Derivatives of 2,5-piperazinedione of formula (I) are apoptotic peptidase activating factor 1 (Apaf-1) inhibitors, therefore they are useful as active pharmaceutical ingredients for the prophylaxis and/or treatment of a pathological and/or physiological condition associated with an increase of apoptosis. | 05-17-2012 |
Ángel Millán Escolando, Zaragoza ES
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20130266509 | METHOD FOR COATING AND FUNCTIONALIZING NANOPARTICLES BY MEANS OF A MICHAEL REACTION - The present invention relates to a method for coating nanoparticles to achieve stable dispersions of said particles in a liquid medium and the surface functionalization thereof with groups that have physical activity such as luminescence, chemical activity such as catalytic capacity and/or biological activity such as a capacity for selectively binding with a biological entity. | 10-10-2013 |
Ángel Millán Escolando, Zaragoza ES
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20130266509 | METHOD FOR COATING AND FUNCTIONALIZING NANOPARTICLES BY MEANS OF A MICHAEL REACTION - The present invention relates to a method for coating nanoparticles to achieve stable dispersions of said particles in a liquid medium and the surface functionalization thereof with groups that have physical activity such as luminescence, chemical activity such as catalytic capacity and/or biological activity such as a capacity for selectively binding with a biological entity. | 10-10-2013 |
Ángel Pey Rodríguez, Zaragoza ES
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20100286166 | COMPOSITIONS FOR THE TREATMENT OF HYPERPHENYLALANINEMIA - The present invention relates to the use of specific types of compounds acting as pharmacological chaperones having a stabilizing activity on the phenylalanine hydroxylase (PAH) enzyme for the prophylaxis and/or treatment of hyperphenylalaninemia (HPA) and phenylketonuria PKU) and diseases, disorders and conditions related thereto. Further, the present invention relates to pharmaceutical compositions containing the compounds according to the present invention as well as to methods of treatment of HPA, in particular, PKU and diseases, disorders and conditions related thereto. | 11-11-2010 |
Ángel Pey Rodríguez, Zaragoza ES
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20100286166 | COMPOSITIONS FOR THE TREATMENT OF HYPERPHENYLALANINEMIA - The present invention relates to the use of specific types of compounds acting as pharmacological chaperones having a stabilizing activity on the phenylalanine hydroxylase (PAH) enzyme for the prophylaxis and/or treatment of hyperphenylalaninemia (HPA) and phenylketonuria PKU) and diseases, disorders and conditions related thereto. Further, the present invention relates to pharmaceutical compositions containing the compounds according to the present invention as well as to methods of treatment of HPA, in particular, PKU and diseases, disorders and conditions related thereto. | 11-11-2010 |
Ángel Rodríguez Bartolomé, Madrid ES
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20100086905 | SIMULATION SYSTEM FOR ARTHROSCOPIC SURGERY TRAINING - The invention relates to a simulator for training in arthroscopic surgery on a joint of a simulated patient, comprising: a data processing unit ( | 04-08-2010 |
Ángel Rodríguez Bartolomé, Madrid ES
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20100086905 | SIMULATION SYSTEM FOR ARTHROSCOPIC SURGERY TRAINING - The invention relates to a simulator for training in arthroscopic surgery on a joint of a simulated patient, comprising: a data processing unit ( | 04-08-2010 |
Ángel RodrÍguez VÁzquez, Sevilla ES
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20150310298 | DEVICE FOR THE HARDWARE DETECTION OF LOCAL EXTREMES IN AN IMAGE - A device and method for the hardware detection of local edges in an image, comprised of a plurality of elemental cells for mixed signal processing, locally interconnected with each other, comprising in each cell a first switch configured to enable the pre-charging of a condenser at the supply voltage; and where once said condenser is pre-charged, it discharges via a second switch connected to a power source which varies in a monotonically increasing manner with the analogue voltage representing the value of the pixel concerned; and where the value of the pixel is compared asynchronously with the neighbouring pixels of the neighbouring cells via two inverters, a digital NOR gate, a digital NAND gate, a third and fourth switch and a memory feature to store the result. | 10-29-2015 |
Ángel Rumbero Sánchez, Armilla-Granada ES
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20110319484 | NEUROPROTECTIVE COMPOUNDS - The invention describes the use of (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl-1-naphthalenyl propanoate derivatives, optionally mono- or di-methylated at the carbon in the alpha position of propanoic acid, of formula (I), where R is CH | 12-29-2011 |
20120095091 | ANTIEPILEPTIC, HYPOCHOLESTEROLEMIC AND NEUROPROTECTIVE COMPOUND - The present invention describes a compound of formula (I) | 04-19-2012 |
Ángel Rumbero SÁnchez, Armilla-Granada ES
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20140309295 | ANTIEPILEPTIC, HYPOCHOLESTEROLEMIC AND NEUROPROTECTIVE COMPOUND - The present invention describes a compound of formula (I) | 10-16-2014 |
Ángel Santanach Delisau, Vic-Barcelona ES
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20130280325 | COMPRESSED SOLID DOSAGE FORMS - This invention relates to compressed solid oral dosage form able to contain a high load of active pharmaceutical ingredient, showing a controlled release profile, and consisting of individual particles wherein each individual particle comprises an active pharmaceutical ingredient and wherein each individual particle is coated with a layer comprising at least one plasticizer. | 10-24-2013 |
Ángel Santanach Delisau, Vic-Barcelona ES
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20130280325 | COMPRESSED SOLID DOSAGE FORMS - This invention relates to compressed solid oral dosage form able to contain a high load of active pharmaceutical ingredient, showing a controlled release profile, and consisting of individual particles wherein each individual particle comprises an active pharmaceutical ingredient and wherein each individual particle is coated with a layer comprising at least one plasticizer. | 10-24-2013 |
Ángel Sebastiá Cortés, Valencia ES
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20120136237 | COMPACT, HYBRID AND INTEGRATED GAMMA/RF SYSTEM USED TO FORM SIMULTANEOUS PET OR SPECT AND MR IMAGES - The GAMMA/RF compact, hybrid and integrated system for PET-SPECT/MR simultaneous imaging of the invention comprises a GAMMA/RF device that integrates an RF coil, of the type used in conventional MR systems, with GAMMA radiation detector modules of the type used in PET or SPECT systems, so that combined PET or SPECT and MR images are obtained. | 05-31-2012 |