Jun Liang
Jun Liang, South San Francisco, CA US
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20100292244 | HYDROXYLATED PYRIMIDYL CYCLOPENTANE AS AKT PROTEIN KINASE INHIBITOR - The present invention provides a compound and pharmaceutically acceptable salts thereof, comprising the Formula I. Also provided are methods of using the compound of this invention as an AKT protein kinase inhibitor and for the treatment of hyperproliferative diseases such as cancer. | 11-18-2010 |
20110065716 | HYDROXYLATED PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS - The present invention provides compounds, including pharmaceutically acceptable salts thereof, comprising the Formula (I): Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases, such as cancer. | 03-17-2011 |
20120232055 | HYDROXYLATED AND METHOXYLATED PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS - The present invention provides compounds, including resolved enantiomers, resolved diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula I: | 09-13-2012 |
20130085135 | 5H-CYCLOPENTA[D]PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS - Compounds of Formula I are useful for inhibiting AKT protein kinases. Methods of using compounds of Formula I and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed. | 04-04-2013 |
20130143865 | PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS - The present invention provides compounds of Formula I, including tautomers, resolved enantiomers, diastereomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof. | 06-06-2013 |
20140080829 | PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS - The present invention provides compounds of Formula I, including tautomers, resolved enantiomers, diastereomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof. | 03-20-2014 |
20140315887 | PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS - The present invention provides compounds of Formula I, including tautomers, resolved enantiomers, diastereomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof. | 10-23-2014 |
20140349996 | PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS - The present invention provides compounds of Formula I, including tautomers, resolved enantiomers, diastereomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof. | 11-27-2014 |
20140349997 | HYDROXYLATED AND METHOXYLATED PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS - The present invention provides compounds, including resolved enantiomers, resolved diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula I: | 11-27-2014 |
20140357644 | HYDROXYLATED PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS - The present invention provides compounds, including pharmaceutically acceptable salts thereof, comprising the Formula I: | 12-04-2014 |
20150051217 | HYDROXYLATED PYRIMIDYL CYCLOPENTANE AS AKT PROTEIN KINASE INHIBITOR - The present invention provides a compound and pharmaceutically acceptable salts thereof, comprising the Formula I: | 02-19-2015 |
20150065522 | THERAPEUTIC COMPOUNDS AND USES THEREOF - The present invention relates to compounds formula (I): | 03-05-2015 |
20150197496 | PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS - The present invention provides compounds of Formula I, including tautomers, resolved enantiomers, diastereomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof. | 07-16-2015 |
Jun Liang, Palo Alto, CA US
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20080280873 | Biaryl Substituted Pyrazinones as Sodium Channel Blockers - Biaryl substituted pyrazinone compounds represented by Formula I, or pharmaceutically acceptable salts thereof. Pharmaceutical compositions comprise an effective amount of the instant compounds, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier. Methods of treating conditions associated with, or caused by, sodium channel activity, including, for example, acute pain, chronic pain, visceral pain, inflammatory pain, neuropathic pain, urinary incontinence, itchiness, allergic dermatitis, epilepsy, irritable bowel syndrome, depression, anxiety, multiple sclerosis, and bipolar disorder, comprise administering an effective amount of the present compounds, either alone, or in combination with one or more other therapeutically active compounds. A method of administering local anesthesia comprises administering an effective amount of a compound of the instant invention, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier. | 11-13-2008 |
20080287457 | Inhibitors of Akt Activity - The present invention is directed to compounds which contain substituted naphthyridines which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer comprising administration of the compounds of the invention. These substituted naphthyridines have unexpected advantageous properties when compared to other naphthyridines reported in PCT publication WO2003/086394, such unexpected advantageous properties may include increased cellular potency/solubility, greater selectivity, enhanced pharmacokinetic properties, lack of off target activity and so on. | 11-20-2008 |
20080318989 | Pyrimidine Kinase Inhibitors - The invention provides novel kinase inhibitors that are useful as therapeutic agents for example in the treatment malignancies where the compounds have the general formula (I) wherein ring A, X, Y, Z, R | 12-25-2008 |
20100144732 | PYRIMIDINE KINASE INHIBITORS - The invention provides novel kinase inhibitors that are useful as therapeutic agents for example in the treatment malignancies where the compounds have the general formula I wherein Q, X, Y, Z, R | 06-10-2010 |
20100222321 | Inhibitors of akt activtiy - The instant invention provides for substituted naphthyridine compounds that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting Akt activity by administering the compound to a patient in need of treatment of cancer. | 09-02-2010 |
20100317643 | JANUS KINASE INHIBITOR COMPOUNDS AND METHODS - The invention provides compounds of Formula I, stereoisomers or pharmaceutically acceptable salts thereof, wherein A, B, D, R | 12-16-2010 |
20110015204 | PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS - The present invention provides compounds of Formula (I), including tautomers, resolved enantiomers, diastereomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer. | 01-20-2011 |
20110160221 | PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS - The present invention provides compounds of Formula I, including tautomers, resolved enantiomers, diastereomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer. | 06-30-2011 |
20110245230 | PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS - The present invention provides compounds of Formula I, including tautomers, resolved enantiomers, diastereomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof. | 10-06-2011 |
20120202788 | AZABENZOTHIAZOLE COMPOUNDS, COMPOSITIONS AND METHODS OF USE - Provided are compounds of Formula I, stereoisomers, tautomers, solvates, prodrugs and pharmaceutically acceptable salts thereof, wherein A, X, R | 08-09-2012 |
20120225855 | TRIAZOLOPYRIDINE JAK INHIBITOR COMPOUNDS AND METHODS - A compound of Formula I, enantiomers, diasteriomers, tautomers or pharmaceutically acceptable salts thereof, wherein R | 09-06-2012 |
20130096104 | IMIDAZOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE - The invention provides compounds of Formulas Ia-Ib, stereoisomers or pharmaceutically acceptable salts thereof, wherein A, X, R | 04-18-2013 |
20130252941 | PYRAZOLOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE - The invention provides compounds of Formula I, stereoisomers or pharmaceutically acceptable salts thereof, wherein A, X, R | 09-26-2013 |
20140038939 | TRIAZOLOPYRIDINE JAK INHIBITOR COMPOUNDS AND METHODS - A compound of Formula I, enantiomers, diasteriomers, tautomers or pharmaceutically acceptable salts thereof, wherein R | 02-06-2014 |
20140171408 | AZABENZOTHIAZOLE COMPOUNDS, COMPOSITIONS AND METHODS OF USE - Provided are compounds of Formula I, stereoisomers, tautomers, solvates, prodrugs and pharmaceutically acceptable salts thereof, wherein A, X, R | 06-19-2014 |
20140206702 | IMIDAZOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE - The invention provides compounds of Formulas Ia-Ib, stereoisomers or pharmaceutically acceptable salts thereof, wherein A, X, R | 07-24-2014 |
Jun Liang, Dalian CN
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20100162963 | Manila clam pedigree and breeding process thereof - A process for breeding a Manila clam pedigree, includes: directively breeding present Manila clam pedigrees having different shell shapes to obtain a shell shape pedigree (A) having best phenotypic character; directively breeding the shell shape pedigrees (A) from different geographical populations to obtain a geographical population pedigree (B) having best phenotypic character; directively breeding the geographical population pedigrees (B) having different shell colors to obtain a growth shell color pedigree (C) of fastest growth and a resistance shell color pedigrees (E) of highest stress resistance; hybridizing the growth shell color pedigree (C) and the resistance shell color pedigree (E) to obtain a first hybridied pedigree (F | 07-01-2010 |
20100162964 | Process for polycross breeding Manila clam pedigree - A process for polycross breeding a Manila clam pedigree, includes: providing present Manila clam pedigrees of different shell color types as parents; ecologically maturing the parents; reciprocally hybridizing the parents by every two of different shell color types to obtain offsprings thereof; nurturing the offsprings until gonads thereof mature synchronously; and hybridizing the matured offsprings with each other to obtain at least a four-way cross pedigree accumulating all valuable genes of the parents. | 07-01-2010 |
Jun Liang, Boyds, MD US
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20110166061 | LONG LASTING FUSION PEPTIDE INHIBITORS FOR HIV INFECTION - The present invention is concerned with This invention relates to C34 peptide derivatives that are inhibitors of viral infection and/or exhibit antifusogenic properties. In particular, this invention relates to C34 derivatives having inhibiting activity against human immunodeficiency virus (HIV), respiratory syncytial virus (RSV), human parainfluenza virus (HPV), measles virus (MeV), and simian immunodeficiency virus (SIV) with long duration of action for the treatment of the respective viral infections. | 07-07-2011 |
Jun Liang, Shanghai CN
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20110202669 | Method for Network Domain Name Resolution and the Resolution Device Thereof - The invention relates to a method for network domain name resolution, the domain name comprises a first portion domain name and a second portion domain name, and the resolution method comprising following steps: In a first network system, resolving the first portion domain name into a first network address; In the first network system, searching for a first network node corresponding to the first network address according to the resolved first network address; In a second network system, resolving the second portion domain name into a second network node address, and the domain name resolution system of the second network system being independent of the domain name resolution system of the first network system. As the resolution structure of the domain name in the Intranet is independent of the resolution structure of the domain name in the Internet, the IP address of the Intranet will not occupy the IP address resource of the Internet. | 08-18-2011 |
Jun Liang, Lanzhou CN
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20120261266 | Process for Producing A Coating On The Surface Of A Substrate Based On Lightweight Metals By Plasma-electrolytic Oxidation - The present invention relates to a process for producing a coating on the surface of a substrate by plasma-electrolytic oxidation. Improved corrosion protection for lightweight metals, in particular for magnesium or magnesium alloys, is achieved by the process. Furthermore, biocompatible protective layers can also be produced on these materials, with the option of controlling degradation of the substrate. The layers are amorphous. They are produced by plasma-electrolytic oxidation in which the substrate is dipped as electrode together with a counterelectrode into an electrolyte liquid and a sufficient electric potential for generating spark discharges at the surface of the substrate is applied, wherein the electrolyte comprises clay particles dispersed therein. Substrates can therefore be any machine components, automobile components, railroad components, aircraft components, ships' components, etc., or bioimplants such as bone replacement materials or medical bone screws made of a lightweight metal such as magnesium or a magnesium alloy. | 10-18-2012 |
Jun Liang, Zhuhai CN
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20130216265 | DRIVING FORCE TRANSMISSION MECHANISM AND PROCESS CARTRIDGE CONTAINING THE SAME - A driving force transmission mechanism comprising a photosensitive drum driving member, wherein the photosensitive drum driving member is engaged with an image forming apparatus driving member and receives the driving force from the image forming apparatus driving member; the image forming apparatus driving member comprises a triangular groove having a triangular cross-section and driving force transmission portion disposed in three vertex angles of the triangular groove; the photosensitive drum driving member comprises a non-distorting protrusion which is axially extended from the end face of a drum shaft and engaged with the groove on the image forming apparatus driving member; the protrusion has a position-limiting mechanism and a stressed mechanism; a projecting tooth obliquely disposed on said non-distorting protrusion is taken as the stressed mechanism; and each projecting tooth also has a mating surface which is engaged with the driving force transmission component to transmit the driving force. | 08-22-2013 |
20140029982 | DRIVING FORCE TRANSMISSION MECHANISM FOR IMAGE FORMING APPARATUS AND PROCESSING CARTRIDGE - The present invention provides a driving force transmission mechanism for an image forming apparatus and a process cartridge. The transmission mechanism includes a photosensitive drum driving component ( | 01-30-2014 |
Jun Liang, Changsha CN
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20130265765 | QUICK INSTALLATION MULTIFUNCTIONAL DISPLAY - The invention relates to a quick installation multifunctional display comprising at least two display units, connecting pieces for connecting the display units together; said display unit comprises a frame formed by four side walls, and through-holes are formed in the side walls of the frame, said connecting pieces connect the display units together by the through-holes in the side walls of the frame. The quick installation multifunctional display of the present invention could be formed by connecting the display units together through the connecting pieces, which makes the installation very convenient; furthermore, the workload and time for installation of the quick installation multifunctional display could be decreased, which lowers the installation costs. | 10-10-2013 |
Jun Liang, Shenzhen CN
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20140002501 | METHOD AND TERMINAL DEVICE FOR FILTERING OBJECTS | 01-02-2014 |
20150100925 | Menu Showing Method, Apparatus, and Device - The present invention discloses a menu showing method, apparatus, and device, and relates to the field of user interface technologies. The method includes: dividing a menu system into multiple menu groups according to functional characteristic, and determining menu group loaded information, where the menu group loaded information includes a location sequence in which each of the menu groups is displayed; determining a display mode of each menu group in the multiple menu groups according to the location sequence in which each of the menu groups is displayed in the menu group loaded information; and displaying each menu group on a current interface according to the menu group loaded information and the display mode of each menu group. | 04-09-2015 |
Jun Liang, Lewisham AU
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20140235348 | SENSOR-BASED GAMING SYSTEM FOR AN AVATAR TO REPRESENT A PLAYER IN A VIRTUAL ENVIRONMENT - A method of providing a sensor-based gaming system for an avatar to represent a player in a virtual environment includes wirelessly receiving a set of measurements describing attributes of the player. The method includes generating a player profile associated with the player and including an avatar depicting a virtual embodiment of the player in a virtual world. The method includes receiving sensor data from sensors. The sensor data describes a change in a real world position of the player. The method includes determining an estimate of a player movement. The method includes determining a difference between a screen position of the avatar in the virtual world and the real world position of the player in the real world. The method includes generating avatar image data representative of movement of the avatar corresponding to movement of the player. | 08-21-2014 |
Jun Liang, Wuhan CN
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20150215246 | MESSAGING AND TASK MANAGEMENT DEVICE AND METHOD THEREOF - A method for organizing a task includes creating the task in an application run in an electronic device, selecting one or more other users to join the task, adding the task to a schedule of a first user and the selected users who use the application, and determining a best communication system to use to inform the selected users about the task. The application includes a number of embedded communication systems. Message correspondence records of all of the embedded communication systems are displayable on a single interface of the application. The first user can send messages to other users through the embedded communication systems, and receive messages from the other users through the corresponding embedded communication systems. The task is created by the first user selecting one or more messages from a message correspondence record of the embedded communication systems. | 07-30-2015 |