Patent application number | Description | Published |
20120101538 | DEVICES, SYSTEMS AND METHODS FOR EVALUATION AND FEEDBACK OF NEUROMODULATION TREATMENT - The present disclosure relates to devices, systems and methods for evaluating the success of a treatment applied to tissue in a patient, such as a radio frequency ablative treatment used to neuromodulate nerves associated with the renal artery. A system monitors parameters or values generated during the course of a treatment. Feedback provided to an operator is based on the monitored values and relates to an assessment of the likelihood that a completed treatment was technically successful. In other embodiments, parameters or values generated during the course of an incomplete treatment (such as due to high temperature or high impedance conditions) may be evaluated to provide additional instructions or feedback to an operator. | 04-26-2012 |
20120116382 | CATHETER APPARATUSES HAVING MULTI-ELECTRODE ARRAYS FOR RENAL NEUROMODULATION AND ASSOCIATED SYSTEMS AND METHODS - Catheter apparatuses, systems, and methods for achieving renal neuromodulation by intravascular access are disclosed herein. One aspect of the present technology, for example, is directed to a treatment device having a multi-electrode array configured to be delivered to a renal blood vessel. The array is selectively transformable between a delivery or low-profile state (e.g., a generally straight shape) and a deployed state (e.g., a radially expanded, generally helical shape). The multi-electrode array is sized and shaped so that the electrodes or energy delivery elements contact an interior wall of the renal blood vessel when the array is in the deployed (e.g., helical) state. The electrodes or energy delivery elements are configured for direct and/or indirect application of thermal and/or electrical energy to heat or otherwise electrically modulate neural fibers that contribute to renal function or of vascular structures that feed or perfuse the neural fibers. | 05-10-2012 |
20120143293 | CATHETER APPARATUSES HAVING MULTI-ELECTRODE ARRAYS FOR RENAL NEUROMODULATION AND ASSOCIATED SYSTEMS AND METHODS - Catheter apparatuses, systems, and methods for achieving renal neuromodulation by intravascular access are disclosed herein. One aspect of the present technology, for example, is directed to a treatment device having a multi-electrode array configured to be delivered to a renal blood vessel. The array is selectively transformable between a delivery or low-profile state (e.g., a generally straight shape) and a deployed state (e.g., a radially expanded, generally helical shape). The multi-electrode array is sized and shaped so that the electrodes or energy delivery elements contact an interior wall of the renal blood vessel when the array is in the deployed (e.g., helical) state. The electrodes or energy delivery elements are configured for direct and/or indirect application of thermal and/or electrical energy to heat or otherwise electrically modulate neural fibers that contribute to renal function or of vascular structures that feed or perfuse the neural fibers. | 06-07-2012 |
20130289682 | CATHETER ASSEMBLIES FOR NEUROMODULATION PROXIMATE A BIFURCATION OF A RENAL ARTERY AND ASSOCIATED SYSTEMS AND METHODS - Catheter assemblies for neuromodulation proximate a renal artery bifurcation and associated systems and methods are disclosed herein. A catheter assembly configured in accordance with a particular embodiment of the present technology can include a shaft having a proximal portion, a distal portion, and two therapeutic arms extending from the distal portion. The shaft can be configured to deliver the distal portion to a treatment site proximate a branch point or bifurcation in a renal blood vessel. The therapeutic arms can include energy delivery elements that are configured to deliver the therapeutically-effective energy to renal nerves proximate the branch point. | 10-31-2013 |
20130296767 | Methods and Apparatus for Performing a Non-Continuous Circumferential Treatment of a Body Lumen - Methods and apparatus are provided for non-continuous circumferential treatment of a body lumen. Apparatus may be positioned within a body lumen of a patient and may deliver energy at a first lengthwise and angular position to create a less-than-full circumferential treatment zone at the first position. The apparatus also may deliver energy at one or more additional lengthwise and angular positions within the body lumen to create less-than-full circumferential treatment zone(s) at the one or more additional positions that are offset lengthwise and angularly from the first treatment zone. Superimposition of the first treatment zone and the one or more additional treatment zones defines a non-continuous circumferential treatment zone without formation of a continuous circumferential lesion. Various embodiments of methods and apparatus for achieving such non-continuous circumferential treatment are provided. | 11-07-2013 |
20130304054 | METHODS AND APPARATUS FOR PERFORMING RENAL NEUROMODULATION VIA CATHETER APPARATUSES HAVING INFLATABLE BALLOONS - Methods and apparatus are provided for non-continuous circumferential treatment of a body lumen. Apparatus may be positioned within a body lumen of a patient and may deliver energy at a first lengthwise and angular position to create a less-than-full circumferential treatment zone at the first position. The apparatus also may deliver energy at one or more additional lengthwise and angular positions within the body lumen to create less-than-full circumferential treatment zone(s) at the one or more additional positions that are offset lengthwise and angularly from the first treatment zone. Superimposition of the first treatment zone and the one or more additional treatment zones defines a non-continuous circumferential treatment zone without formation of a continuous circumferential lesion. Various embodiments of methods and apparatus for achieving such non-continuous circumferential treatment are provided. | 11-14-2013 |
20130304064 | METHODS AND APPARATUS FOR PERFORMING RENAL NEUROMODULATION VIA CATHETER APPARATUSES HAVING INFLATABLE BALLOONS - Methods and apparatus are provided for non-continuous circumferential treatment of a body lumen. Apparatus may be positioned within a body lumen of a patient and may deliver energy at a first lengthwise and angular position to create a less-than-full circumferential treatment zone at the first position. The apparatus also may deliver energy at one or more additional lengthwise and angular positions within the body lumen to create less-than-full circumferential treatment zone(s) at the one or more additional positions that are offset lengthwise and angularly from the first treatment zone. Superimposition of the first treatment zone and the one or more additional treatment zones defines a non-continuous circumferential treatment zone without formation of a continuous circumferential lesion. Various embodiments of methods and apparatus for achieving such non-continuous circumferential treatment are provided. | 11-14-2013 |
20140114305 | METHODS AND APPARATUS FOR THERMALLY-INDUCED RENAL NEUROMODULATION - Methods and apparatus are provided for thermally-induced renal neuromodulation. Thermally-induced renal neuromodulation may be achieved via direct and/or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers. In some embodiments, parameters of the neural fibers, of non-target tissue, or of the thermal energy delivery element, may be monitored via one or more sensors for controlling the thermally-induced neuromodulation. In some embodiments, protective elements may be provided to reduce a degree of thermal damage induced in the non-target tissues. In some embodiments, thermally-induced renal neuromodulation is achieved via delivery of a pulsed thermal therapy. | 04-24-2014 |
Patent application number | Description | Published |
20140270526 | METHOD FOR SEGMENTING TEXT WORDS IN DOCUMENT IMAGES - A word segmentation method for processing a document image applies clustering analysis to the spacing segments of a line. The spacing segments are generated by thresholding a one-dimensional vertical projection profile of the line. Taking advantage of the bimodal distribution of spacing length distribution of text lines, a k-means clustering algorithm is used, with the number of clusters pre-set to two, to classify the spacing segments as either character spacing or word spacing. Moreover, k-means++ initialization is used to enhance performance of cluster analysis. The clustering result such as cluster centers and compactness is used to prune single-word text line, single table item, etc. The locations of the word spacing segments are then used to segment the line of text into words. | 09-18-2014 |
20150052426 | REMOVAL OF UNDERLINES AND TABLE LINES IN DOCUMENT IMAGES WHILE PRESERVING INTERSECTING CHARACTER STROKES - A method for removing horizontal and vertical lines in a document image while preserving integrity of the character strokes that intersect the lines. For each detected horizontal line, a vertical run length profile is calculated. Areas of the run length profile having two adjacent peaks with a valley in between are detected, which correspond to intersections of the horizontal line with non-vertical lines. A first derivative curve may be used to detect such peaks and valleys. Areas of the run length profile with large run length value for consecutive pixel locations are also detected, which corresponds to intersections of the horizontal line with near vertical lines. The horizontal line is removed in areas outside of the intersection areas, while preserving pixels within the intersection areas. Vertical line removal may be done similarly. This template-free method can remove lines in tables, forms, and underline and extract handwriting or printed characters. | 02-19-2015 |
20150063699 | LINE SEGMENTATION METHOD APPLICABLE TO DOCUMENT IMAGES CONTAINING HANDWRITING AND PRINTED TEXT CHARACTERS OR SKEWED TEXT LINES - A text line segmentation method for a document image containing printed text and handwriting, or document image containing skewed lines or printed text. Connected component (CC) are obtained for the document, and their bounding boxes and centroids are calculated. The CCs are categorized into three categories based on bounding box sizes: small objects, regular text objects, and large objects involving handwriting. The centroids of regular text objects are used in a cluster analysis to find the vertical centers of the N text lines. Then, each CC is classified into one of the N lines based on the vertical distance between its centroid and the vertical centers of text lines, and copied into to a corresponding object board. Extra spaces are removed from the object boards to obtain the line segments. The large object involving handwriting will be classified into one of the lines but absent from other lines. | 03-05-2015 |
20150178907 | Context-Based Inspection for Dark Field Inspection - Methods and systems for detecting defects on a wafer are provided. One method includes altering one or more design clips based on how the one or more design clips will appear in output generated by a wafer inspection process for a wafer. The method also includes aligning the one or more altered design clips to the output generated for the wafer during the wafer inspection process. In addition, the method includes detecting defects on the wafer based on the output aligned to the one or more altered design clips. | 06-25-2015 |
Patent application number | Description | Published |
20130106837 | DEPTH-MAP GENERATION FOR AN INPUT IMAGE USING AN EXAMPLE APPROXIMATE DEPTH-MAP ASSOCIATED WITH AN EXAMPLE SIMILAR IMAGE | 05-02-2013 |
20140118494 | Depth Map Generation From a Monoscopic Image Based on Combined Depth Cues - A combined depth map is generated for a monoscopic image based on a weighted combination of a color depth map, a spatial depth map, and a motion depth map for the image, each describing the depth of pixels in the image relative to the image plane. The color depth map determines the depth of pixels according to their color, the spatial depth map determines the depth of pixels according to their location in the image, and the motion depth map determines the depth of pixels according to their motion in the image. Each of the depth maps is associated with a weight that is used to generate the weighted combination. The weights are adaptive to account for variation between different monoscopic images. | 05-01-2014 |
20140147033 | CONVERSION OF MONOSCOPIC VISUAL CONTENT USING IMAGE-DEPTH DATABASE - An image converter compiles three-dimensional content into a data store, identifies a number of stereo image pairs from the three-dimensional content, computes a depth map for each of the stereo image pairs from the three-dimensional content, and partitions the stereo image pairs in the data store into multiple categories. The image converter determines a depth cue for each of the categories based on the depth map for each of the stereo image pairs in each category. The image converter computes a depth map for a category associated with a two-dimensional input image based on the determined depth cue and renders a three-dimensional output image from the two-dimensional input image using the depth map for the category. | 05-29-2014 |
20150304630 | Depth Map Generation from a Monoscopic Image Based on Combined Depth Cues - A combined depth map is generated for a monoscopic image based on a weighted combination of a color depth map, a spatial depth map, and a motion depth map for the image, each describing the depth of pixels in the image relative to the image plane. The color depth map determines the depth of pixels according to their color, the spatial depth map determines the depth of pixels according to their location in the image, and the motion depth map determines the depth of pixels according to their motion in the image. Each of the depth maps is associated with a weight that is used to generate the weighted combination. The weights are adaptive to account for variation between different monoscopic images. | 10-22-2015 |
Patent application number | Description | Published |
20100164950 | EFFICIENT 3-D TELESTRATION FOR LOCAL ROBOTIC PROCTORING - An apparatus is configured to show telestration in 3-D to a surgeon in real time. A proctor is shown one side of a stereo image pair, such that the proctor can draw a telestration line on the one side with an input device. Points of interest are identified for matching to the other side of the stereo image pair. In response to the identified points of interest, regions and features are identified and used to match the points of interest to the other side. Regions can be used to match the points of interest. Features of the first image can be matched to the second image and used to match the points of interest to the second image, for example when the confidence scores for the regions are below a threshold value. Constraints can be used to evaluate the matched points of interest, for example by excluding bad points. | 07-01-2010 |
20100166323 | ROBUST SPARSE IMAGE MATCHING FOR ROBOTIC SURGERY - Systems, methods, and devices are used to match images. Points of interest from a first image are identified for matching to a second image. In response to the identified points of interest, regions and features can be identified and used to match the points of interest to a corresponding second image or second series of images. Regions can be used to match the points of interest when regions of the first image are matched to the second image with high confidence scores, for example above a threshold. Features of the first image can be matched to the second image, and these matched features may be used to match the points of interest to the second image, for example when the confidence scores for the regions are below the threshold value. Constraint can be used to evaluate the matched points of interest, for example by excluding bad points. | 07-01-2010 |
20110025929 | Light Transport Matrix from Homography - Aspects of the present invention include systems and methods for obtaining a light transport between a projector and a camera. In embodiments, the light transport between the projector and the camera is represented as a matrix and is obtained assuming that the projector displays on a surface that is planar or at least substantially planar. The light transport matrix is obtained by finding a homography between the projector and the camera. Using the homography to correlate camera and projector pixels and using color values in a captured solid color image, the light transport matrix can be obtained. In embodiments, at least an approximation of an inverse light transport matrix can also be computed, which is useful for many applications, such as inferring unknown projector images. | 02-03-2011 |
20110081058 | Reconstructing Three-Dimensional Current Sources from Magnetic Sensor Data - Magnetic source imaging (MSI) involves the reconstruction of the current sources in a portion of a body, such as an organ, from measured magnetic field data. The measured magnetic field data may be from one-dimensional or three-dimensional sensors. Aspects of the present invention include systems and methods for reconstructing the electrical current of an organ given magnetic data. In embodiments, reconstruction of three-dimensional current sources is accomplished knowing or estimating the position, or offset, of the sensor plane with respect to the patient in order to form a set of linear equations. Alternatively, reconstruction of three-dimensional current sources is accomplished without knowing the offset of the sensor plane with respect to the patient. In embodiments, the linear and nonlinear systems of equations are iteratively used to obtain the current source information. In embodiments, multi-scale strategies are employed. | 04-07-2011 |
20110304888 | Removing Leakage from a Double-Sided Document - Aspects of the present invention include systems and methods for mitigating the effects of leakage when duplicating an image from a double-sided document. In embodiments, a device is calibrated by computing a leakage function. The leakage function is used to obtain a leakage mitigation function. Given the leakage function and the leakage mitigation function, an estimate of a true version of the document image can be obtained using as inputs only the images of the front-side and back-side of the double-sided document. | 12-15-2011 |
20120197145 | High-Resolution Magnetocardiogram Restoration for Cardiac Electric Current Localization - Magnetocardiogram (MCG) provides temporal and spatial measurements of cardiac electric activities, which permits current localization. An MCG device usually consists of a small number of magnetic sensors in a planar array. Each sensor provides a highly low-resolution 2D MCG map. Such a low-res map is insufficient for cardiac electric current localization. To create a high resolution MCG image from the sparse measurements, an algorithm based on model learning is used. The model is constructed using a large number of randomly generated high resolution MCG images based on the Biot-Savart Law. By fitting the model with the sparse measurements, high resolution MCG image are created. Next, the 2D position of the electric current is localized by finding the peak in the tangential components of the high resolution MCG images. Finally, the 2D current localization is refined by a non-linear optimization algorithm, which simultaneously recovers the depth of the electric current from the sensor and its magnitude and orientation. | 08-02-2012 |
20120219195 | 3D Current Reconstruction From 2D Dense MCG Images - A current dipole is determined by solving the inverse problem multiple times in consecutive stages. At each stage, a new high resolution image is generated from a magnetic field map from the immediately previous stage, and at each stage more constraints are extracted from the current high resolution image than were available in the immediately previous stage. After the constraints are extracted from a current high resolution image, the current high resolution is updated to incorporate constraints from the immediately previous stage. The updated high resolution image, and the currently extracted constraints are used to resolve the inverse problem, and the Biot-Savart law is used to calculated the current dipole. | 08-30-2012 |
20120237095 | ROBUST SPARSE IMAGE MATCHING FOR ROBOTIC SURGERY - Systems, methods, and devices are used to match images. Points of interest from a first image are identified for matching to a second image. In response to the identified points of interest, regions and features can be identified and used to match the points of interest to a corresponding second image or second series of images. Regions can be used to match the points of interest when regions of the first image are matched to the second image with high confidence scores, for example above a threshold. Features of the first image can be matched to the second image, and these matched features may be used to match the points of interest to the second image, for example when the confidence scores for the regions are below the threshold value. Constraint can be used to evaluate the matched points of interest, for example by excluding bad points. | 09-20-2012 |
20130079622 | Denoise MCG Measurements - A magnetocardiogram (MCG) system with reduced noise artifacts is produced by first creating high-resolution image representations of low-resolution measurements obtained with a magnetic field sensor unit. The high-resolution image representations are created by use of a PCA model that has been trained using a library of ideal, no-noise, high-resolution images. The Biot-Sarvart Law is then used to create a 3D model of a current impulse, given the high-resolution image representations. From the 3D current impulse model, ideal sensor unit measurements as they would have been obtained using a theoretical sensor unit observing the 3D current impulse model are synthesized. | 03-28-2013 |
20130317337 | Continuous Modeling for Dipole Localization from 2D MCG Images with Unknown Depth - A system identifies double-layer dipoles in a magnetic image by defining two-dimensional patches of distributed point charges that simulate the double-layer dipoles. The geometric center of a two-dimensional patch is used as the location of an equivalent dipole moment of the double-layer dipole. The momentum of the equivalent dipole moment is determined by submitting the magnetic image to a dipole construction system that identifies the location and momentum based on the submitted magnetic image. | 11-28-2013 |
20130324832 | 2D Dipole Localization Using Absolute Value of MCG Measurements - A magnetic imaging systems produces magnetic magnitude images using magnetic sensors capable of determining only the absolute value of a detected magnetic field and provide no information regarding the positive or negative sign of the detected magnetic image. A 2D dipole location is determines the 2D location of a dipole within a magnetic magnitude image by finding the minimum of the derivative of the absolute value of the magnetic field. This 2D dipole location is then used to determine the 3D position and momentum of a current dipole responsible for the observed magnetic magnitude image. The current dipole is used to generate a magnetic image that incorporate positive and negative sign information. | 12-05-2013 |
20150025392 | EFFICIENT 3-D TELESTRATION FOR LOCAL AND REMOTE ROBOTIC PROCTORING - An apparatus is configured to show telestration in 3-D to a surgeon in real time. A proctor is shown one side of a stereo image pair, such that the proctor can draw a telestration line on the one side with an input device. Points of interest are identified for matching to the other side of the stereo image pair. In response to the identified points of interest, regions and features are identified and used to match the points of interest to the other side. Regions can be used to match the points of interest. Features of the first image can be matched to the second image and used to match the points of interest to the second image, for example when the confidence scores for the regions are below a threshold value. Constraints can be used to evaluate the matched points of interest, for example by excluding bad points. | 01-22-2015 |
Patent application number | Description | Published |
20120061124 | ELECTRODES WITH ELECTROSPUN FIBERS - In accordance with various example embodiments, an apparatus includes two or more circuit nodes and a conductive material that is located between and configured to electrically couple the circuit nodes. The conductive material includes a network of elongated portions of at least one electrospun Cu-based nanostructure. Each elongated portion has an aspect ratio of at least 50,000 and a length that is greater than 100 microns, and at least one fused crossing point that joins with a fused crossing point of another of the elongated portions. The network of elongated portions is distributed and aligned in the conductive material to set a conductance level and a transparency level along the network, along at least one direction. | 03-15-2012 |
20140045065 | LI-ION BATTERY ELECTRODES HAVING NANOPARTICLES IN A CONDUCTIVE POLYMER MATRIX - Aspects of the present disclosure are directed towards energy storage devices, and methods of manufacturing such devices. Energy storage devices, consistent with the present disclosure, include a source of lithium ions, a plurality of nanoparticles, and a conductive polymer network. The nanoparticles are encapsulated in conductive polymer shells and volumetrically change due to lithiation and delithiation due to movement of the lithium ions created by an electrical potential. The conductive polymer network bonds to the nanoparticles and accommodates volumetric changes of the plurality of nanoparticles during lithiation and delithiation. | 02-13-2014 |
20140329120 | RECHARGEABLE BATTERY SAFETY BY MULTIFUNCTIONAL SEPARATORS AND ELECTRODES - A battery includes: 1) an anode; 2) a cathode; 3) a separator disposed between the anode and the cathode, wherein the separator includes at least one functional layer; and 4) a sensor connected to the at least one functional layer to monitor an internal state of the battery. | 11-06-2014 |
20150056435 | TRANSPARENT CONDUCTING ELECTRODES COMPRISING MESOSCALE METAL WIRES - A composition suitable for use in a transparent conducting electrode (TCE) is disclosed. The composition comprises a conductive background medium and an incorporated plurality of mesoscale metal wires. The composition is characterized by lower electrical sheet resistance as compared to prior-art compositions for TCEs without a significant degradation in optical transmittance. | 02-26-2015 |
Patent application number | Description | Published |
20120095862 | COMPUTER SYSTEM AND METHOD FOR ANALYZING DATA SETS AND GENERATING PERSONALIZED RECOMMENDATIONS - Embodiments of the invention relate to a computer-implemented method and system for generating personalized recommendations for a target user based at least on stored data about the target user. The method comprises obtaining, at the server computer, data from a plurality of data sources, including entity data associated with a plurality of entities, stored in an entity database, or personal data associated with a plurality of users, stored in a user database. The personalized recommendations system then merges the entity data or personal data and maps the entity or personal data to a corresponding entity or target user, respectively. The entity or personal data is differentiated, a relevance is determined, a weight is assigned to the data and corresponding source to canonicalize the data, the respective databases are updated with the corresponding data, and then a set of personalized recommendations to the target user is generated using the updated databases. | 04-19-2012 |
20130024465 | METHOD AND APPARATUS FOR QUICKLY EVALUATING ENTITIES - Embodiments of the invention relate to methods and systems for evaluating entities for a target user, the method comprising obtaining, at a server computer, entity data from a plurality of data sources. The entity data is then stored in an entity database. The method further comprises merging the entity data from the plurality of data sources, mapping the entity data to a corresponding entity, and differentiating the entity. Then a relevance is determined associated with the entity data and data source. The method further comprises generating a set of entity evaluations to the target user using the relevance, determining a set of one or more entities relevant to the primary user based on the entity data, user data, and the relevance, with an initial order of relevance, and displaying, on a user device, the set of relevant entities to the target user in the order of relevance. | 01-24-2013 |
Patent application number | Description | Published |
20120067343 | Aerosol Composition for Administering Drugs - Described here are compositions and methods for the treatment of respiratory conditions using glucocorticosteroids delivered by a next generation nebulizer. The methods administer a therapeutic dose with nebulization time of 2 minutes or less. The faster nebulization time improves patient compliance. | 03-22-2012 |
20120135046 | CORTICOSTEROID PARTICLES AND METHOD OF PRODUCTION - A new particle morphology of glucocorticosteroids is described. The forms have a particle morphology that is particularly well suited for use in an inhaled corticosteroid drug suspension formulation for delivery from a next generation nebulizer device. Use of the new glucocorticosteroid particles enables enhanced drug delivery efficiency and increased residence time of the delivered drug in the lungs. New methods for producing glucocorticosteroid particles having these specific particle morphologies are also described. The methods provide a simplified, reproducible and scalable particle formation process that can produce glucocorticosteroid particles having a narrow particle size and shape distribution, a low surface energy, a low aspect ratio, uniform particle morphology and a reduced specific surface area. | 05-31-2012 |
20130156823 | Excipient-free Aerosol Formulation - Methods and compositions for producing formulations for orally inhaled benzodiazepines that do not require the presence of a surface modifier are described. The formulations are useful in the treatment of epileptic seizures. | 06-20-2013 |
20140120165 | CORTICOSTEROID PARTICLES AND METHOD OF PRODUCTION - A new particle morphology of glucocorticosteroids is described. The forms have a particle morphology that is particularly well suited for use in an inhaled corticosteroid drug suspension formulation for delivery from a next generation nebulizer device. Use of the new glucocorticosteroid particles enables enhanced drug delivery efficiency and increased residence time of the delivered drug in the lungs. New methods for producing glucocorticosteroid particles having these specific particle morphologies are also described. The methods provide a simplified, reproducible and scalable particle formation process that can produce glucocorticosteroid particles having a narrow particle size and shape distribution, a low surface energy, a low aspect ratio, uniform particle morphology and a reduced specific surface area. | 05-01-2014 |
20140179705 | 8'-HYDROXY-DIHYDROERGOTAMINE COMPOUNDS AND COMPOSITIONS - 8′-Hydroxy-Dihydroergotamine (8′-OH DHE) medicinal compounds, compositions, and dosage forms containing such compositions are provided. Also provided herein are methods of treatment, prevention, or amelioration of diseases, conditions or disorders selected from amyotrophic lateral sclerosis (ALS), Parkinson's disease, stress/anxiety, nausea, emesis, aggression, pain, neuropathic pain, sleeplessness, insomnia, restless leg syndrome and depression using the compounds, compositions, dosage forms and administration techniques disclosed herein. | 06-26-2014 |
20140179706 | FLUOROERGOLINE DERIVATIVES AND USES THEREOF - Provided herein are novel fluoroergoline derivatives and compositions thereof. In other embodiments, provided herein are methods of treatment, prevention, or amelioration of a variety of medical disorders such as, for example, migraine using the compounds and compositions disclosed herein. In still other embodiments, provided herein are methods of agonizing receptors such as, for example, the 5-HT | 06-26-2014 |
20140179707 | NOVEL ERGOLINE DERIVATIVES AND USES THEREOF - Provided herein are 8′-Hydroxy-2-CF3-dihydroergotamine (8′OH-2-CF3-DHE) compounds, compositions, and dosage forms containing such compositions. Also provided herein are methods of treatment, prevention, or amelioration of a variety of medical disorders such as, for example, migraine using the compounds and compositions disclosed herein. In still other embodiments, provided herein are methods of agonizing receptors such as, for example, the 5-HT | 06-26-2014 |
20140179730 | NOVEL METHYSERGIDE DERIVATIVES - Provided herein are novel methysergide derivatives and compositions thereof. In other embodiments, provided herein are methods of treatment, prevention, or amelioration of a variety of medical disorders or symptoms thereof, such as, migraine and Parkinson's disease using the compounds and compositions disclosed herein. In still other embodiments, provided herein, such as, for example, are methods for antagonizing the 5-HT | 06-26-2014 |
20140377189 | PULMONARY ADMINISTRATION OF ROTIGOTINE - Provided herein are methods and compositions for producing formulations systemic delivery of dopamine agonists via the oral inhalation route. Specifically, provided herein are methods and compositions for a stable solution formulation of rotigotine that is suitable for administration via oral inhalation. Such methods and compositions are useful in the treatment or amelioration of one or more Parkinson's disease symptom(s). | 12-25-2014 |
20140377365 | SUSTAINED-RELEASE FORMULATION OF ROTIGOTINE - Provided herein are methods and compositions for producing formulations systemic delivery of dopamine agonists via the oral inhalation route. Specifically, provided herein are methods and compositions for a formulation of rotigotine that is suitable for administration via oral inhalation. Such methods and compositions are useful in the treatment or amelioration of one or more Parkinson's disease symptom(s). | 12-25-2014 |
20150038525 | NOVEL METHYSERGIDE DERIVATIVES - Provided herein are novel methysergide derivatives and compositions thereof. In other embodiments, provided herein are methods of treatment, prevention, or amelioration of a variety of medical disorders or symptoms thereof, such as, migraine and Parkinson's disease using the compounds and compositions disclosed herein. In still other embodiments, provided herein, such as, for example, are methods for antagonizing the 5-HT | 02-05-2015 |
20150133456 | FLUOROERGOLINE DERIVATIVES AND USES THEREOF - Provided herein are novel fluoroergoline derivatives and compositions thereof. In other embodiments, provided herein are methods of treatment, prevention, or amelioration of a variety of medical disorders such as, for example, migraine using the compounds and compositions disclosed herein. In still other embodiments, provided herein are methods of agonizing receptors such as, for example, the 5-HT | 05-14-2015 |
20150265531 | AEROSOL COMPOSITION FOR ADMINISTERING DRUGS - Described here are compositions and methods for the treatment of respiratory conditions using glucocorticosteroids delivered by a next generation nebulizer. The methods administer a therapeutic dose with nebulization time of 2 minutes or less. The faster nebulization time improves patient compliance. | 09-24-2015 |
Patent application number | Description | Published |
20090099641 | DELIVERY SYSTEM FOR MEDICAL DEVICES - The invention is directed a delivery system for implantation a self-expanding medical device in a body which includes a control handle and a catheter portion. The catheter portion includes an outer restraining member which covers the collapsed, medical device, an inner catheter member having a distal end including a region upon which the medical device is mounted, and an outer sheath which is removably attached to the control handle. The outer sheath creates a conduit for the catheter portion to prevent the inner catheter member from moving axially when the outer restraining member is retracted. The control handle has a rotatable thumbwheel to actuate a retraction mechanism attached to the proximal end of the outer restraining member which moves the restraining member in a proximal direction to deploy the medical device. | 04-16-2009 |
20100109204 | Polymeric Stent Polishing Method And Apparatus - A method and apparatus for simultaneously polishing the inner and outer surfaces of an unpolished polymeric stent using a heat process. The unpolished stent can be mounted, for example, on a “spiral-mandrel,” a tubular helical structure with gaps in between a series of coils of the structure. Heat from a heat source can then applied to the spiral-mandrel at a range between the glass transition temperature and melting temperature of the polymer of the stent. | 05-06-2010 |
20100145431 | DELIVERY SYSTEM FOR MEDICAL DEVICES - The invention is directed a delivery system for implantation a self-expanding medical device in a body which includes a control handle and a catheter portion. The catheter portion includes an outer restraining member which covers the collapsed, medical device, an inner catheter member having a distal end including a region upon which the medical device is mounted, and an outer sheath which is removably attached to the control handle. The outer sheath creates a conduit for the catheter portion to prevent the inner catheter member from moving axially when the outer restraining member is retracted. The control handle has a rotatable thumbwheel to actuate a retraction mechanism attached to the proximal end of the outer restraining member which moves the restraining member in a proximal direction to deploy the medical device. | 06-10-2010 |
20110000070 | Method And Apparatus For Attaching Radiopaque Markers To A Stent - A mandrel for supporting a stent and rollers for pressing a radiopaque marker into a stent are disclosed. The mandrel can have a forward portion for carrying the stent and a rear portion for urging the stent forward portion into a gap between the rollers. The mandrel may be pushed or pulled into the gap, which is sized to allow the rollers to press the marker into engagement with the stent. Prior to moving the mandrel into the gap, the marker may be placed on a surface of the stent or partially inside a recess in the stent. Several markers can be efficiently and uniformly pressed onto the stent by moving the mandrel into the gap in one continuous movement in an axial or lateral direction. Markers can also be pressed onto the stent by placing the stent in the gap and rotating the stent about its central axis. | 01-06-2011 |
20110034988 | Stent Island Removal - A tool, system, and method for removing islands from a stent is disclosed. The tool includes a tube with at least one exit hole in communication with the interior of the tube, and the tube being connected to a pressurized fluid source. A stent island is located over the exit hole and is removed by the force of the exiting fluid from the exit hole. | 02-10-2011 |
20120144663 | APPARATUS FOR ATTACHING RADIOPAQUE MARKERS TO A STENT - A mandrel for supporting a stent and rollers for pressing a radiopaque marker into a stent are disclosed. The mandrel can have a forward portion for carrying the stent and a rear portion for urging the stent forward portion into a gap between the rollers. The mandrel may be pushed or pulled into the gap, which is sized to allow the rollers to press the marker into engagement with the stent. Prior to moving the mandrel into the gap, the marker may be placed on a surface of the stent or partially inside a recess in the stent. Several markers can be efficiently and uniformly pressed onto the stent by moving the mandrel into the gap in one continuous movement in an axial or lateral direction. Markers can also be pressed onto the stent by placing the stent in the gap and rotating the stent about its central axis. | 06-14-2012 |
20120151744 | METHOD FOR ATTACHING RADIOPAQUE MARKERS TO A STENT - A mandrel for supporting a stent and rollers for pressing a radiopaque marker into a stent are disclosed. The mandrel can have a forward portion for carrying the stent and a rear portion for urging the stent forward portion into a gap between the rollers. The mandrel may be pushed or pulled into the gap, which is sized to allow the rollers to press the marker into engagement with the stent. Prior to moving the mandrel into the gap, the marker may be placed on a surface of the stent or partially inside a recess in the stent. Several markers can be efficiently and uniformly pressed onto the stent by moving the mandrel into the gap in one continuous movement in an axial or lateral direction. Markers can also be pressed onto the stent by placing the stent in the gap and rotating the stent about its central axis. | 06-21-2012 |
20140167324 | POLYMERIC STENT POLISHING METHOD AND APPARATUS - A method and apparatus for simultaneously polishing the inner and outer surfaces of an unpolished polymeric stent using a heat process. The unpolished stent can be mounted, for example, on a “spiral-mandrel,” a tubular helical structure with gaps in between a series of coils of the structure. Heat from a heat source can then applied to the spiral-mandrel at a range between the glass transition temperature and melting temperature of the polymer of the stent. | 06-19-2014 |
20150107085 | APPARATUS FOR ATTACHING RADIOPAQUE MARKERS TO A STENT - A mandrel for supporting a stent and rollers for pressing a radiopaque marker into a stent are disclosed. The mandrel can have a forward portion for carrying the stent and a rear portion for urging the stent forward portion into a gap between the rollers. The mandrel may be pushed or pulled into the gap, which is sized to allow the rollers to press the marker into engagement with the stent. Prior to moving the mandrel into the gap, the marker may be placed on a surface of the stent or partially inside a recess in the stent. Several markers can be efficiently and uniformly pressed onto the stent by moving the mandrel into the gap in one continuous movement in an axial or lateral direction. Markers can also be pressed onto the stent by placing the stent in the gap and rotating the stent about its central axis. | 04-23-2015 |
Patent application number | Description | Published |
20120303608 | METHOD AND SYSTEM FOR CACHING LEXICAL MAPPINGS FOR RDF DATA - Disclose is an improved approach for caching lexical values for RDF data. A compact, efficient resource ID to value mapping is stored in memory, where the cache is stored in memory such that the overhead of accessing and updating it is minimized. The advantage of this approach is improved query performance, since the database is performing less work with the in-memory RDF resource caching. In addition, throughput and performance of the database are also improved. | 11-29-2012 |
20130318070 | INTEGRATING APPLICATIONS WITH AN RDF REPOSITORY THROUGH A SPARQL GATEWAY - A method, system, and computer program product for of processing database queries using the resource description framework (RDF) language through a gateway service. The method commences by receiving a database query (e.g., an SQL query) from an application, the query being in a first query language format, then converting the query into a SPARQL query format and submitting the converted query to a SPARQL endpoint. The SPARQL endpoint processes the SPARQL query (e.g., by accessing an RDF repository), and sends back the query results. A gateway service (e.g., a SPARQL gateway) then receives the SPARQL query results from the SPARQL endpoint and transforms the SPARQL query results into a format corresponding to the first query language format so the initiating application can process it natively. Several performance features are disclosed, including a method for achieving a quality of service level by concurrently submitting multiple SPARQL queries with different LIMIT clauses. | 11-28-2013 |
20140310260 | USING PERSISTENT DATA SAMPLES AND QUERY-TIME STATISTICS FOR QUERY OPTIMIZATION - Techniques for storing and querying graph data in a key-value store are provided. A graph statement (e.g., an RDF graph statement) includes a plurality of values, at least two of which correspond to nodes in a graph. A key is generated based on the graph statement. The key may be generated based on concatenating hash values that are generated based on the plurality of values. The key-value store stores the key. The value that corresponds to the key may be a null or empty value. In response to a graph query (e.g., in SPARQL) that includes one or more query patterns, each of which includes one or more values, a key is generated based on the one or more values and sent to the key-value store, which returns one or more other keys, each of which is a superset of the generated key. | 10-16-2014 |
20140310302 | STORING AND QUERYING GRAPH DATA IN A KEY-VALUE STORE - Techniques for storing and querying graph data in a key-value store are provided. A graph statement (e.g., an RDF graph statement) includes a plurality of values, at least two of which correspond to nodes in a graph. A key is generated based on the graph statement. The key may be generated based on concatenating hash values that are generated based on the plurality of values. The key-value store stores the key. The value that corresponds to the key may be a null or empty value. In response to a graph query (e.g., in SPARQL) that includes one or more query patterns, each of which includes one or more values, a key is generated based on the one or more values and sent to the key-value store, which returns one or more other keys, each of which is a superset of the generated key. | 10-16-2014 |