Patent application number | Description | Published |
20080242990 | Hair removal using focused high intensity acoustic energy - Hair is permanently removed from a patient's skin by transcutaneously focusing high intensity acoustic energy at a hair follicle and applying sufficient energy to destroy the follicle, whereby hair is removed and regrowth is prevented. Typically, a region of a patient's skin would be ultrasonically imaged to show the location of a plurality of individual hair follicles. The individual imaged hair follicles are then treated using a system which automatically directs the high intensity acoustic energy at each follicle. | 10-02-2008 |
20100228163 | Method of removing and preventing regrowth of hair - Hair is permanently removed from a patient's skin by transcutaneously focusing high intensity acoustic energy at hair follicles and at dermal papilla regions during a telogen phase of hair growth and applying sufficient energy to destroy said follicles and said dermal papilla regions, so that hair is removed and regrowth is prevented. Typically, a region of a patient's skin is first ultrasonically imaged to show the location of a plurality of individual hair follicles and dermal papilla regions. The imaged hair follicles and dermal papilla regions are then treated using a system which automatically directs high intensity acoustic energy at each follicle and dermal papilla region. | 09-09-2010 |
20120215137 | Apparatus and method for improving blood flow in arterioles and capillaries - Disclosed herein is an apparatus and method which are used to improve blood flow in small vessels such as arterioles and capillaries. Method embodiments of the present invention make use of very high frequency (typically 1 MHZ to 100 MHZ) electrical signals in combination with ultrasonic signals typically falling within the same frequency range, where the frequency of the electrical signals and the ultrasonic signals may be the same or different. The electrical signals and ultrasonic signals are applied to a patient simultaneously, typically at a single contact location which is proximate on the exterior of the body to the arterioles and capillaries where blood flow is impaired. | 08-23-2012 |
20130197317 | Detachably-mountable, compact, light for surgical and diagnostic devices - A detachable light for use in combination with surgical and diagnostic devices. The detachable light incorporates multiple functions into a minimum number of elements in the housing of the detachable light. The housing includes aligning gripping elements which align the light to a functional centerline of the surgical or diagnostic device. The housing includes multiple light sources on its exterior surface, where the direction of light output may be adjusted. Exterior surfaces of the detachable light which are in contact with patient tissue are formed from an atraumatic material. | 08-01-2013 |
Patent application number | Description | Published |
20090275496 | Effective quantitation of complex peptide mixtures in tissue samples and improved therapeutic methods - The instant invention provides methods for the detection and quantitation of complex peptide mixtures in tissue samples and functional readouts of the results of administration of such complex peptide mixtures. The instant invention further provides methods for administering complex peptide mixtures to a subject in need thereof, the dosage regimen and quantity determined based on the above mentioned method for detection and quantitation. | 11-05-2009 |
20100080796 | Synthesis of directed sequence polymer compositions and antibodies thereof for the treatment of protein conformational disorders - The instant invention comprises a process for the solid phase synthesis of directed epitope peptide mixtures useful in the treatment and diagnosis of protein conformational disorders, such process defined by a set of rules regarding the identity and the frequency of occurrence of amino acids that substitute a base or native amino acid of a known epitope. The resulting composition is a mixture of related peptides for therapeutic use. The invention also pertains to the process of generating antibodies using the directed epitope peptide mixtures as the antigens, and antibodies generated by such process, useful in the treatment and diagnostics of the said protein conformational disorder. | 04-01-2010 |
20100316714 | METHODS OF TREATING DISEASE WITH RANDOM COPOLYMERS - The invention relates to novel methods and kits for treating or preventing disease through the administration of random copolymers comprising amino acids tyrosine (Y), phenylalanine (F), alanine (A), and lysine (K). The invention also relates to the treatment of autoimmune diseases, such as multiple sclerosis, and to the administration of random copolymers in treatment regimen comprising formulations that are administered at intervals greater than 24 hours, or to sustained release formulations which administer the copolymer over a period greater than 24 hours. The invention further relates to methods for conducting a pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the formulations or dosing regimens of random copolymer described herein. | 12-16-2010 |
20110129497 | Methods for designing and preparing vaccines comprising directed sequence polymer compositions via the directed expansion of epitopes - The instant invention comprises a process of preparing a composition comprising directed sequence polymer (DSP) mixtures that act as epitopes and useful as vaccines, such DSP synthesized according to a set of rules regarding the identity and the frequency of occurrence of amino acids that substitute a base or native amino acid of a known epitope. The resulting composition is a mixture of related peptides for therapeutic use as a vaccine, preferably for infectious agents that are immune evasive. | 06-02-2011 |
20140271614 | DIRECTED SEQUENCE POLYMER COMPOSITIONS AND ANTIBODIES THEREOF FOR THE TREATMENT OF PROTEIN CONFORMATIONAL DISORDERS - The instant invention comprises a process for the solid phase synthesis of directed epitope peptide mixtures useful in the treatment and diagnosis of protein conformational disorders, such process defined by a set of rules regarding the identity and the frequency of occurrence of amino acids that substitute a base or native amino acid of a known epitope. The resulting composition is a mixture of related peptides for therapeutic use. The invention also pertains to the process of generating antibodies using the directed epitope peptide mixtures as the antigens, and antibodies generated by such process, useful in the treatment and diagnostics of the said protein conformational disorder. | 09-18-2014 |
Patent application number | Description | Published |
20120276135 | METHODS FOR IMPROVING THE DESIGN, BIOAVAILABILITY, AND EFFICACY OF RANDOM SEQUENCE POLYMER COMPOSITIONS VIA SERUM PROTEIN-BASED DETECTION OF RANDOM SEQUENCE POLYMER COMPOSITIONS - There exist in the art methods of detecting simple peptides. However, methods to determine the effective plasma concentration of mixtures of peptides as a group, rather than for individual peptides with a defined amino acid sequence, are complicated by the heterogeneity of the peptides to be detected. This application provides improved methods of detecting and assessing random sequence polymer (RSP) compositions, methods for the detection and quantitation of RSP compositions, means to determine and enrich a subset of peptides in an RSP composition based on the subset's interactions with certain capture polypeptides, and methods for administering RSP compositions to a subject in need thereof, wherein the dosage regimen and quantity may be determined or evaluated based on the above-mentioned methods for detection and quantitation. | 11-01-2012 |
20120282296 | METHODS FOR IMPROVING THE DESIGN, BIOAVAILABILITY, AND EFFICACY OF DIRECTED SEQUENCE POLYMER COMPOSITIONS VIA SERUM PROTEIN-BASED DETECTION OF DIRECTED SEQUENCE POLYMER COMPOSITIONS - There exist in the art methods of detecting simple peptides. However, methods to determine the effective plasma concentration of directed sequence polymers (DSPs), are complicated because DSPs are complex mixtures of peptides, as opposed to individual peptides with a defined amino acid sequence. This application provides improved methods of detecting and assessing DSP compositions, methods for the detection and quantitation of DSP compositions, means to determine and enrich a subset of peptides in a DSP composition based on the subset's interactions with certain capture polypeptides, and methods for administering DSP compositions to a subject in need thereof, wherein the dosage regimen and quantity may be determined or evaluated based on the above-mentioned methods for detection and quantitation. | 11-08-2012 |
20140328869 | METHODS FOR IMPROVING THE DESIGN, BIOAVAILABILITY, AND EFFICACY OF RANDOM SEQUENCE POLYMER COMPOSITIONS VIA SERUM PROTEIN-BASED DETECTION OF RANDOM SEQUENCE POLYMER COMPOSITIONS - There exist in the art methods of detecting simple peptides. However, methods to determine the effective plasma concentration of mixtures of peptides as a group, rather than for individual peptides with a defined amino acid sequence, are complicated by the heterogeneity of the peptides to be detected. This application provides improved methods of detecting and assessing random sequence polymer (RSP) compositions, methods for the detection and quantitation of RSP compositions, means to determine and enrich a subset of peptides in an RSP composition based on the subset's interactions with certain capture polypeptides, and methods for administering RSP compositions to a subject in need thereof, wherein the dosage regimen and quantity may be determined or evaluated based on the above-mentioned methods for detection and quantitation. | 11-06-2014 |
Patent application number | Description | Published |
20100016343 | ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR INHIBITORS - The present invention provides compounds and compositions, methods of making them, and methods of using them to modulate α7 nicotinic acetylcholine receptors and/or to treat any of a variety of disorders, diseases, and conditions. Provided compounds can affect, among other things, neurological, psychiatric and/or inflammatory system. | 01-21-2010 |
20100016360 | ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR INHIBITORS - The present invention provides compounds and compositions, methods of making them, and methods of using them to modulate α7 nicotinic acetylcholine receptors and/or to treat any of a variety of disorders, diseases, and conditions. Provided compounds can affect, among other things, neurological, psychiatric and/or inflammatory system. | 01-21-2010 |