Patent application number | Description | Published |
20100155323 | FUNCTIONALIZED NONWOVEN ARTICLE - A grafted nonwoven substrate is disclosed having average fiber sizes of 0.7 to 15 microns, and a void volume of 50 to 95%, and a polymer comprising cationic aminoalkyl(meth)acryloyl monomer units grafted to the surface of the nonwoven substrate. The article may be used as a filter element to purify or separate target materials, such as oligonucleotides or monoclonal antibodies (MAb), from a fluid mixture. | 06-24-2010 |
20100320138 | FUNCTIONALIZED NONWOVEN ARTICLE - A grafted nonwoven substrate is disclosed having average fiber sizes of 0.7 to 15 microns, and a void volume of 50 to 95%, and a polymer comprising anionic monomer units grafted to the surface of the nonwoven substrate. The article may be used as a filter element to purify or separate target materials, such as monoclonal antibodies (MAb), from a fluid mixture. | 12-23-2010 |
20110006007 | COMPOSITE POLYMERIC FILTRATION MEDIA - Provided are filtration media, matrixes, and systems for liquid purification that utilize functional polymer particles. The functional polymer particles can comprise a cationic charge. Exemplary functional polymer particles comprise comprise [3-(methacryloylamino)propyl]-trimethylammonium chloride (MAPTAC) polymerized with trimethylolpropane trimethacrylate (TMPTMA). | 01-13-2011 |
20110033633 | METHOD OF MAKING LIGAND FUNCTIONALIZED SUBSTRATES - Ligand functionalized substrates, methods of making ligand functionalized substrates, and methods of using functionalized substrates are disclosed. | 02-10-2011 |
20110100916 | SOLID SUPPORT WITH A GRAFTED CHAIN - Articles that contain a solid support with a grafted chain extending from the solid support, methods of making these articles, and various uses of the articles are described. More specifically, the grafted chain has a functional group that can react with or interact with target compound. Alternatively, the functional group on the grafted chain can react with a modifying agent to provide another group that can react with or interact with the target compound. The grafted chains are attached to the solid support through a ring-opened azlactone group. The articles can be used to purify the target compound or to separate the target compound from other molecules in a sample. | 05-05-2011 |
20110201078 | LIGAND FUNCTIONALIZED POLYMERS - Ligand functionalized substrates, methods of making ligand functionalized substrates, and methods of using functionalized substrates are disclosed. | 08-18-2011 |
20110217752 | LIGAND FUNCTIONALIZED POLYMERS - Ligand functionalized substrates, methods of making ligand functionalized substrates, and methods of using functionalized substrates are disclosed. | 09-08-2011 |
20120252091 | LIGAND FUNCTIONAL SUBSTRATES - A substrate comprising a crosslinked polymer primer layer, and grafted thereto a ligand-functionalized polymer is provided. The grafted polymer has the requisite affinity for binding neutral or negatively charged biomaterials, such as cells, cell debris, bacteria, spores, viruses, nucleic acids, and proteins, at pH's near or below the pI's of the biomaterials. | 10-04-2012 |
20130090397 | SEMI-INTERPENETRATING POLYMER NETWORK - Semi-interpenetrating polymeric networks are described. More specifically, the semi-interpenetrating polymeric networks include at least two polymers that are closely associated. The first polymer is an ionic polymer that is not crosslinked. The second polymer is a cross-linked polymer that can be either another ionic polymer or a non-ionic polymer. Methods of making the semi-interpenetrating polymeric networks, articles containing the semi-interpenetrating polymeric networks, and methods of using the semi-interpenetrating polymeric networks are also described. The semi-interpenetrating polymeric networks can function as ion exchange resins. | 04-11-2013 |
20130092620 | FUNCTIONALIZED NONWOVEN ARTICLE - A grafted nonwoven substrate is disclosed having average fiber sizes of 0.7 to 15 microns, and a void volume of 50 to 95%, and a polymer comprising cationic aminoalkyl(meth)acryloyl monomer units grafted to the surface of the nonwoven substrate. The article may be used as a filter element to purify or separate target materials, such as oligonucleotides or monoclonal antibodies (MAb), from a fluid mixture. | 04-18-2013 |
20130122215 | FUNCTIONALIZED NONWOVEN ARTICLE - A grafted nonwoven substrate is disclosed having average fiber sizes of 0.7 to 15 microns, and a void volume of 50 to 95%, and a polymer comprising anionic monomer units grafted to the surface of the nonwoven substrate. The article may be used as a filter element to purify or separate target materials, such as monoclonal antibodies (MAb), from a fluid mixture. | 05-16-2013 |
20130137158 | LIGAND FUNCTIONALIZED POLYMERS - Ligand functionalized substrates, methods of making ligand functionalized substrates, and methods of using functionalized substrates are disclosed. | 05-30-2013 |
20130217032 | LIGAND FUNCTIONALIZED POLYMERS - Ligand functionalized substrates, methods of making ligand functionalized substrates, and methods of using functionalized substrates are disclosed. | 08-22-2013 |
20130224825 | LIGAND FUNCTIONALIZED POLYMERS - Ligand functionalized substrates, methods of making ligand functionalized substrates, and methods of using functionalized substrates are disclosed. | 08-29-2013 |
20140046029 | SOLID SUPPORT WITH A GRAFTED CHAIN - Articles that contain a solid support with a grafted chain extending from the solid support, methods of making these articles, and various uses of the articles are described. More specifically, the grafted chain has a functional group that can react with or interact with target compound. Alternatively, the functional group on the grafted chain can react with a modifying agent to provide another group that can react with or interact with the target compound. The grafted chains are attached to the solid support through a ring-opened azlactone group. The articles can be used to purify the target compound or to separate the target compound from other molecules in a sample. | 02-13-2014 |
20140087445 | METHOD OF MAKING LIGAND FUNCTIONALIZED SUBSTRATES - Ligand functionalized substrates, methods of making ligand functionalized substrates, and methods of using functionalized substrates are disclosed. | 03-27-2014 |
20140364519 | METHOD OF MAKING LIGAND FUNCTIONALIZED SUBSTRATES - Ligand functionalized substrates, methods of making ligand functionalized substrates, and methods of using functionalized substrates are disclosed. | 12-11-2014 |
20150136698 | GRAFT COPOLYMER FUNCTIONALIZED ARTICLE - Guanidinyl ligand-functionalized polymers, methods of making the same, and substrates bearing a grafted coating of the ligand-functional polymers are described. The grafted polymer has the requisite affinity for binding neutral or negatively charged biomaterials, such as cells, cell debris, bacteria, spores, viruses, nucleic acids, endotoxins and proteins, at pH's near or below the pI's of the biomaterials. | 05-21-2015 |
Patent application number | Description | Published |
20130325892 | APPLICATION SEARCH QUERY CLASSIFIER - A user can input a search query. By assessing terms in the search query, the search query can be categorized (e.g., as a navigational, functional or browse query). The categorization can depend on an analysis of terms in the search query, a preliminary search, and/or empirical data tied to previous and similar searches. For example, searches estimated to be directed to finding a specific app can be categorized as navigational, based on capitalized letters, quotation marks, a short number of words in the query, and a tight distribution of apps typically downloaded subsequent to viewing results from the search. Based on the categorization, a search strategy can be identified. Search strategies can differentially weight and/or use text-based strategies. | 12-05-2013 |
20140067846 | APPLICATION QUERY CONVERSION - A set of potential search-query terms can be identified based on empirical queries for apps. For each potential search-query term, a subset of documents within a set of documents can be identified based on apps that users were likely to click on or download following entry of a search query with a comparable or same term. One or more other indicator terms can be identified as being related to the potential search-query term based on the one or more second indicator terms being prevalent within the subset of documents. Upon receipt of a subsequent search query, a search can then be performed using both a term within the search query and one or more related other indicator terms. | 03-06-2014 |
20140218392 | INTELLIGENT ADJUSTMENT OF MAP VIEWPORTS AT LAUNCH - A method of selectively displaying maps on a mobile device. The method sends a map application, which had been displaying a first map, to the background. The method then returns the map application to the foreground. The method then determines whether to redisplay the previous map or display a map surrounding the then current location of the device. The determination is based on various factors including user interaction, time that the map application has been in the background and distance traveled while the map application is in the background. | 08-07-2014 |
Patent application number | Description | Published |
20140088641 | FILLED BALLOON ARTERIOTOMY LOCATOR FOR VASCULAR CLOSURE DEVICES AND METHODS - A tissue puncture locator device includes an anchor assembly and a sealing member. The anchor assembly includes an anchor portion, a tube portion, and a filling member. The anchor portion is positioned at a distal end of the tube portion and configured for placement through a vascular incision into a vessel. The anchor member has an unexpanded configuration that permits passage through the vascular incision and an expanded configuration that limits passage through the vascular incision. The filling member is retained in the tube portion and adapted for insertion from the tube portion into the anchor member to provide the expanded configuration, and adapted for retraction from the anchor member into the tube portion to provide the unexpanded configuration. The sealing member is configured for placement adjacent the vascular incision outside the vessel. | 03-27-2014 |
20140128910 | SNAP-ON VASCULAR CLOSURE DEVICE AND METHODS - A tissue puncture closure assembly including a wire assembly and a sealing pad delivery device, The wire assembly includes a proximal end portion, a distal end portion, and a temporary expandable anchor positioned at the distal end portion. The sealing pad delivery device includes a carrier tube, a sealing pad positioned in the carrier tube, and a lateral wire slot. The lateral wire slot is defined in an outer surface of the sealing pad delivery device and extends along at least a portion of a length of the sealing pad delivery device. The lateral wire slot is configured to permit mounting of the sealing pad delivery device to the wire assembly in a lateral direction. | 05-08-2014 |
20140135823 | AUTOMATIC SEALANT DELIVERY CATHETER RETRACTION FOR VASCULAR CLOSURE DEVICE AND METHODS - A vessel puncture closure device includes a balloon catheter and a sealant delivery device. The balloon catheter has an inflatable balloon positioned at a distal end thereof. The sealant delivery catheter has a sealant lumen configured to delivery a volume of sealant to a vessel puncture. The sealant delivery catheter is configured to move axially relative to the balloon between a first position in which the sealant delivery catheter delivers a first volume of sealant to the vessel puncture, and a second position spaced proximal of the first position to deliver a second volume of sealant to the vessel puncture. | 05-15-2014 |
20140194925 | METHOD AND SYSTEM FOR CLOSING A VASCULAR HOLE - Various embodiments of methods for closing vascular holes and associated vascular closure devices are described herein. The methods, generally speaking, use hemostatic devices intended to stop bleeding by closing vascular access puncture sites following percutaneous diagnostic or therapeutic procedures. The methods may include positioning a sealing plug in the vascular hole. In one embodiment, the sealing plug may extend through the vascular hole into the vessel. The sealing plug may expand and thereby create a lip inside the vessel that holds the sealing plug in place. | 07-10-2014 |
20140316400 | ABLATION SYSTEM, METHODS, AND CONTROLLERS - Multi-electrode ablation systems, methods, and controllers are described. In one example, a method of beginning an ablation procedure using a multi-electrode ablation system is described. The method includes selectively coupling the output of a power supply to a first electrode of a plurality of electrodes to increase a temperature at the first electrode to a first temperature set-point and limit a rate of increase of the temperature at the first electrode to a predetermined first rate. | 10-23-2014 |
Patent application number | Description | Published |
20090054926 | EXTRA-VASCULAR SEALING DEVICE AND METHOD - Various embodiments of a device are shown and disclosed for closing a vascular access puncture site following percutaneous diagnostic or therapeutic interventional procedures. In one embodiment, the closure device includes a vessel locating member, an anchor and a sealing material. The closure device may be configured to deploy the anchor and the sealing material outside of a hole in a blood vessel to close the hole. The vessel locating member may be used to locate the blood vessel to ensure that the anchor and/or the sealing material are properly placed adjacent to the hole. The closure device may also include a tamper member configured to push or tamp the sealing material against the anchor. The closure device may also include a suture that is used to hold the sealing material and the anchor together adjacent to the hole in the blood vessel. | 02-26-2009 |
20090171281 | SYSTEMS AND METHODS FOR LOCATING AND CLOSING A TISSUE PUNCTURE - A vascular closure device includes a main body and an expandable portion that can be selectively expanded and contracted. The vascular closure device may be used to close the hole in a wall of a vessel after a medical procedure. For example, the vascular closure device may be used to close the hole in an artery after a medical procedure that required access to the artery. In one embodiment, the expandable portion may be oriented at an oblique angle relative to the main body. This may be desirable in situations where the vessel puncture is oriented at an angle relative to the vessel. Orienting the expandable portion at an oblique angle relative to the main body may help the expandable portion to cover the hole in the wall of the vessel. | 07-02-2009 |
20090171282 | VASCUAR CLOSURE DEVICE HAVING A FLOWABLE SEALING MATERIAL - Various embodiments of a device are shown and disclosed for closing a vascular access puncture site following percutaneous diagnostic or therapeutic interventional procedures. The vascular closure device is configured to safely and accurately deploy a sealing material that undergoes a phase change when deployed inside the tissue tract. The sealing material may be a solid at room temperature and a liquid or gel at body temperature. Also, the sealing material may change from a liquid or gel to a cubic phase when it comes into contact with bodily fluids. | 07-02-2009 |
20090171387 | VASCULAR CLOSURE DEVICE HAVING AN IMPROVED PLUG - Various embodiments of a device are shown and disclosed for closing a vascular access puncture site following percutaneous diagnostic or therapeutic interventional procedures. The vascular closure device includes an improved plug that is configured to be positioned adjacent to the hole in the vasculature. The plug may be shaped to prevent the plug from moving away from the hole in the blood vessel due to pulsatile pressure from the blood. In one embodiment, the plug may include a plurality of projections that extend outward from the plug and contact surrounding tissue in the tissue puncture tract to prevent the plug from moving away from the hole in the blood vessel. | 07-02-2009 |
20100145366 | THREE-NEEDLE CLOSURE DEVICE - The present invention relates to a three-needle type vascular closure system. The closure system utilizes three needles in the form of a guiding device, an expandable needle, and a hooking device. The guiding device is used to make the initial opening in the vessel, where the opening provides access for a sheath through which a medical procedure is to be performed. The expandable needle is inserted into the vessel in which it expands radially from the needle to form a target. The hooking device is also inserted into the vessel and is used to hook the expandable needle so as to form an internal union between the hooking device and the expandable needle. The needles can then be retracted thereby extending a suture from the hooking device and forming an internal suture pass that can be used to approximate the tissue surrounding the initial opening in the vessel. In one embodiment, the suture is passed across the vessel opening prior to dilation of the vessel opening. | 06-10-2010 |
20110077598 | VASCULAR ACCESS TO CLOSURE SHEATH AND METHODS - An insertion sheath and related methods include a tube member and a shape memory feature. The tube member defines an insertion lumen. The shape memory feature is positioned at a distal end portion of the tube member. The shape memory feature provides a monofold shape in the tube member when in a first state, and a radially expanded shape in the tube member in a second state upon application of an expansion force. The shape memory feature returns the monofold shape after removal of the expansion force. The insertion sheath may function as an access to closure sheath that is suitable for use as a procedural insertion sheath when treating the patient and a closure insertion sheath when sealing closed the vascular puncture. | 03-31-2011 |
20120004671 | SUTURE LOOP CLOSURE DEVICE - The present invention describes apparatus and methods for tying a filament across subcutaneous punctures. According to some embodiments, the apparatus and methods provide pre-tied knots that are inserted into a bodily lumen. Needles flanking the subcutaneous puncture are inserted into the lumen and grab the pre-tied knots. The pre-tied knots are pulled through tiny holes flanking the subcutaneous puncture by the needles, leaving an internal length of the filament across the subcutaneous puncture. The filament is then externally tied, closing the subcutaneous puncture. | 01-05-2012 |
20120071919 | VASCULAR SEALING DEVICE WITH HIGH SURFACE AREA SEALING PLUG - An internal tissue puncture closure method and apparatus. The method and apparatus provide a folded sealing plug that provides more surface area than conventional plugs to more fully cover and seal an external situs of an internal tissue puncture. The folded sealing plug may have a weave pattern that tends to cause the sealing plug to corkscrew into the internal tissue puncture as it is compressed toward an anchor placed inside of the tissue puncture. | 03-22-2012 |
20120158045 | VASCULAR CLOSURE DEVICE WITH AUTOMATIC SUTURE CUTTER - A tissue puncture closure device that includes an anchor ( | 06-21-2012 |
20120165854 | MONORAIL SYSTEM FOR VASCULAR CLOSURE DEVICE AND METHODS - A tissue puncture closure assembly including a wire assembly and first and second devices. The wire assembly includes a first wire member and a second wire member that each include a distal end portion and a proximal end portion. At least portions of the second wire member are arranged side-by-side with the first wire member. The distal end portion of the first wire member is connected to the distal end portion of the second wire member, and a proximal end portion of the first wire member is disconnected from the proximal end portion of the second wire member. The first device is operable to advance over the first wire member. The second device is operable to advance over the second wire member. | 06-28-2012 |
20120245624 | SNAP-ON VASCULAR CLOSURE DEVICE AND METHODS - A tissue puncture closure assembly including a wire assembly and a sealing pad delivery device. The wire assembly includes a proximal end portion, a distal end portion, and a temporary expandable anchor positioned at the distal end portion. The sealing pad delivery device includes a carrier tube, a sealing pad positioned in the carrier tube, and a lateral wire slot. The lateral wire slot is defined in an outer surface of the sealing pad delivery device and extends along at least a portion of a length of the sealing pad delivery device. The lateral wire slot is configured to permit mounting of the sealing pad delivery device to the wire assembly in a lateral direction. | 09-27-2012 |
20120283770 | COMPRESSIBLE ARTERIOTOMY LOCATOR FOR VASCULAR CLOSURE DEVICES AND METHODS - A tissue puncture locator device includes a temporary anchor configured for placement through a vascular puncture into a vessel. The temporary anchor includes a column member that defines a lumen. The temporary anchor is movable between an uncompressed position and a compressed position, wherein in the compressed position a portion of the column member protrudes radially outward. The column member may include a reduced thickness portion, wherein the column member protrudes radially outward at the reduced thickness portion. The column member, when expanded radially outward within the vessel, is sized to limit retraction of the temporary anchor through the vascular puncture. | 11-08-2012 |
20130006299 | VASCULAR CLOSURE DEVICE HAVING A FLOWABLE SEALING MATERIAL - Various embodiments of a device are shown and disclosed for closing a vascular access puncture site following percutaneous diagnostic or therapeutic interventional procedures. The vascular closure device is configured to safely and accurately deploy a sealing material that undergoes a phase change when deployed inside the tissue tract. The sealing material may be a solid at room temperature and a liquid or gel at body temperature. Also, the sealing material may change from a liquid or gel to a cubic phase when it comes into contact with bodily fluids. | 01-03-2013 |
20130144316 | LARGE BORE CLOSURE DEVICE AND METHODS - A vascular closure system includes a body portion, an anchor, a suture carrying portion, and a plurality of needles. The body portion has a distal end surface. The anchor is positionable through a vessel puncture in a vessel wall of a vessel. The anchor defines a vessel contact surface, wherein withdrawal of the anchor captures a portion of the vessel wall between the vessel contact surface and the distal end surface. The suture carrying portion is positionable through the vessel puncture and carries at least one suture member. The plurality of needles extend through the portion of the vessel wall adjacent to the vessel puncture and are configured to connect to the at least one suture member. Withdrawal of the plurality of needles through the portion of the vessel wall positions the at least one suture member through the portion of the vessel wall. | 06-06-2013 |
20130150884 | BALLOON INSERTION APPARATUS AND METHOD OF SEALING A TISSUE PUNCTURE - The present invention provides apparatus and methods of closing internal tissue punctures. The apparatus and method provide for an introducer sheath having at least one side port enabling aspiration of an internal tissue puncture site and injection of a sealant. | 06-13-2013 |
20130166023 | COLLAPSIBLE HEART VALVE WITH ANGLED FRAME - A prosthetic heart valve includes a stent and a valve assembly attached to the stent. The stent has a longitudinal axis, a distal end and a proximal end adapted to reside adjacent the aortic annulus of a patient. The proximal end of the stent is oriented at an oblique angle to the longitudinal axis. | 06-27-2013 |
20130297009 | AORTIC BANDS AND METHODS OF USE - A method of testing the performance of a collapsible prosthetic heart valve includes wrapping an aortic band around an outer surface of a portion of an aorta, fastening a first end portion of the aortic band to a second end portion of the aortic band, implanting a collapsible prosthetic heart valve in the aorta at an implantation site, and flowing a pressurized fluid through the aorta. The aortic band may be positioned near the sinotubular junction of the aorta. When installed around the aorta, the aortic band reinforces the portion of the aorta so as to be more resistant to radial expansion. | 11-07-2013 |
Patent application number | Description | Published |
20140011206 | DETERMINATION OF OOCYTE QUALITY - A method for evaluating the quality of mammalian oocytes comprises determining the expression level of one or more of the genes ACPP, AQP11, CCDC126, CLU, CYP11 A1, CYP19A1, EGR3, FN1, FOSL2, GMNN, HRAS, HSD3B2, HS-D17B1, HSD11B2, HSDL1, IGF1, IGFBP4, IGFBP5, IRS1, KCNK3, KLF6, NEK6, SMAD7 or STC1 in a test sample derived from a cumulus cell or granulosa cell associated with the oocyte, and comparing the expression level of said at least one marker gene expression in the sample with the expression level in a control. Differential expression of the gene between the sample and the control is indicative of the quality of the oocyte. | 01-09-2014 |