Patent application number | Description | Published |
20090038161 | Device for cutting continuously moving zipper - The apparatus provides a cutting device, particularly adapted for cutting a moving length of zipper material in the manufacture of reclosable packages. Upper and lower opposed stationary blades are provided thereby providing opposed cutting edges. A reciprocating blade, with upper and lower cutting surfaces, reciprocates within a slot immediately adjacent to the stationary blades, thereby allowing the reciprocating blade to cut on both its upward and downward reciprocating strokes. | 02-12-2009 |
20090042706 | Method and apparatus for applying hot-melt adhesive to zipper flanges and applying zipper to packages - The disclosure relates to a method and apparatus for the attachment of a zipper to a reclosable package or bag, particular packages or bags of relatively larger sizes. Pinch rollers separate the flanges of the zipper so that the interior walls of the flanges are pointing upward, then hot-melt adhesive is sprayed downwardly onto the flanges. The zipper is then guided over the edge of the horizontally-oriented package or bag by a tube with a longitudinal slot. The package or bag, with the zipper attached, is engaged between a driven-belt apparatus with a nip formed between opposed belts, thereby applying consistent and even pressure to the zipper flanges and assuring that the hot-melt adhesive forms a bond which is consistent, reliable and strong. | 02-12-2009 |
20090044492 | Method for feeding large packages or bags into a reclosable zipper profile attaching device - A device is provided for feeding horizontally oriented packages or bags at a regular interval to a zipper profile attaching device. The loose packages or bags are placed onto a servo-driven lugged chain conveyor wherein the lugs are evenly spaced at the nominal desired center-to-center spacing of the packages or bags. The servo-driven lugged chain conveyor feeds the packages or bags to be captured between upper and lower secondary constant velocity conveyors. The lower secondary constant velocity conveyor includes an encoder which is used to slave the servo of the servo-driven lugged chain conveyor, with an adjustable programmable ratio. This achieves a consistent center-to-center distance of the horizontally oriented packages or bags which are then fed to a zipper profile attaching device. | 02-19-2009 |
20090255215 | Zipper registration using eye-mark encoder - The apparatus uses a servo motor and an accumulator dancer arm to buffer the motion of film, with zipper and clips or sliders already inserted, in a zipper-sealing machine. The servo drives the film to an eye-mark and then stops the film. Upstream of the servo motor, the film and zipper stop so that the zipper can be processed, such as by ultrasonic crush stations and clip insertion stations. Downstream of the servo motor, the film runs out of an accumulator to the bagger/wrapper apparatus. | 10-15-2009 |
Patent application number | Description | Published |
20080262964 | NETWORK BASED USER-TO-USER PAYMENT SERVICE - A network-based payment service and site provides various features for facilitating user-to-user payments. One such feature enables users of the payment service to create pay boxes, or other types of payment objects, that can be incorporated into externally hosted web pages and used to make payments. In some embodiments, the payment objects enable users to make payments directly from the externally hosted web pages. | 10-23-2008 |
20110202626 | COLLECTION AND DISTRIBUTION OF SENSE-ON-DEMAND DATA - A method and system for collecting and distributing sense-on-demand data is provided. The sense-on-demand data system uses a network of centralized computers and remote units. The centralized computers may be operated by or on behalf of the operator of the sense-on-demand data system, and the remote units may be operated by users of the network. The remote units may consist of a variety of mobile and fixed-location devices, such as cellular telephones, personal data assistants, laptop computers, desktop computers, and stand-alone data sensor units. The system receives requests for information, identifies remote units that are proximate to the location, forwards the requests to the identified remote units, receives responses from the remote units, and provides responses to the requester. | 08-18-2011 |
Patent application number | Description | Published |
20140274075 | WEDGE SHAPED CELLS IN A WIRELESS COMMUNICATION SYSTEM - Aspects described herein relate to a network for providing air-to-ground wireless communication in various cells. The network includes a first base station array, each base station of which includes a respective first antenna array defining a directional radiation pattern that is oriented in a first direction, wherein each base station of the first base station array is disposed spaced apart from another base station of the first base station array along the first direction by a first distance. The network also includes a similar second base station array where the second base station array extends substantially parallel to the first base station array and is spaced apart from the first base station array by a second distance to form continuous and at least partially overlapping cell coverage areas between respective base stations of the first and second base station arrays. | 09-18-2014 |
20140274076 | CONCENTRIC CELLS IN A WIRELESS COMMUNICATION SYSTEM - Aspects described herein relate to a base station for providing air-to-ground wireless communication over various altitudes. The base station includes a first antenna array comprising one or more antennas configured to form a first cell coverage area extending substantially from a horizon up to a first elevation angle away from the first antenna array to a predetermined distance from the first antenna array. The base station further includes a second antenna array configured at an uptilt elevation angle to form a second cell coverage area extending at least from the first elevation angle to a second elevation away from the second antenna array, wherein the first cell coverage area and the second cell coverage area are concentric to define the ATG cell at least to the predetermined distance and up to a predetermined elevation. | 09-18-2014 |
20150215792 | WEDGE SHAPED CELLS IN A WIRELESS COMMUNICATION SYSTEM - Aspects described herein relate to a network for providing air-to-ground wireless communication in various cells. The network includes a first base station array, each base station of which includes a respective first antenna array defining a directional radiation pattern that is oriented in a first direction, wherein each base station of the first base station array is disposed spaced apart from another base station of the first base station array along the first direction by a first distance. The network also includes a similar second base station array where the second base station array extends substantially parallel to the first base station array and is spaced apart from the first base station array by a second distance to form continuous and at least partially overlapping cell coverage areas between respective base stations of the first and second base station arrays. | 07-30-2015 |
20150223079 | CONCENTRIC CELLS IN A WIRELESS COMMUNICATION SYSTEM - Aspects described herein relate to a base station for providing air-to-ground wireless communication over various altitudes. The base station includes a first antenna array comprising one or more antennas configured to form a first cell coverage area extending substantially from a horizon up to a first elevation angle away from the first antenna array to a predetermined distance from the first antenna array. The base station further includes a second antenna array configured at an uptilt elevation angle to form a second cell coverage area extending at least from the first elevation angle to a second elevation away from the second antenna array, wherein the first cell coverage area and the second cell coverage area are concentric to define the ATG cell at least to the predetermined distance and up to a predetermined elevation. | 08-06-2015 |
Patent application number | Description | Published |
20090081276 | BIORESORBABLE IMPLANT COMPOSITION - A bioresorbable implant composition includes a polymeric macro- or micro-scaffold and first and second bioactive agents respectively incorporated on or within the polymeric macro- or micro-scaffold. The first and second bioactive agents modulate a different function and/or characteristic of a cell. | 03-26-2009 |
20090274712 | COMPOSITIONS FOR COATING CELL MEMBRANES AND METHODS OF USE THEREOF - In certain aspects, the invention relates to cell delivery compositions comprising a progenitor cell and a targeting moiety, and methods related thereto. Such compositions and methods may be used, for example, in administering a targeted cell therapy cell therapy to a subject. | 11-05-2009 |
20140134140 | MESENCHYMAL STEM CELL COMPOSITIONS FOR THE TREATMENT OF MICROBIAL INFECTIONS - A method of treating a microbial infection in a subject includes administering to the subject a therapeutically effective amount of MSCs and an antimicrobial agent, wherein the MSCs potentiate the therapeutic activity of the antimicrobial agent, and the therapeutically effective amount is the amount effective to inhibit microbial growth and suppress microbial infection associated inflammation in the subject. | 05-15-2014 |
20140314869 | ISOLATING AND THERAPEUTIC USE OF PERIVASCULAR MEDICINAL CELLS - Disclosed are perivascular medicinal cells (PVMCs), methods of isolating PVMCs, and a composition comprising PVMCs having medicinal capabilities. Specifically, the disclosure provides a method of isolating PVMCs from an umbilical cord blood vessel or from bone. The disclosure further provides a method of making an enhanced, autologous bone graft, a method of stimulating bone regeneration comprising administering a therapeutically effective amount of bone-derived PVMCs, a method of reconstructing bone tissue, and methods of treating a disease that affects cellular function. PVMCs capable of secreting a site-dependent trophic factor are also described. | 10-23-2014 |
Patent application number | Description | Published |
20080285977 | Method and apparatus for transmitting optical signals - The present invention addresses the problem of transmitting optical signals with high extinction ratios using low-power drive signals. At present, low-power optical transmitters typically operate with modulation extinction ratios of, at best, about 10 dB. Embodiments of the present invention may achieve extinction ratios exceeding 20 dB using low-power drive signals of under 20 mW at data rates on the order of Gbits/sec. In addition, the modulation may be achieved with both low-power and low-fidelity drive waveforms, enabling conventional and often noisy high-speed, low-power electronics to generate high-extinction, high-fidelity optical waveforms. | 11-20-2008 |
20100111540 | FILTER-BASED DPSK RECEIVER - A filter-based method of demodulating differentially encoded phase shift keyed (DPSK) optical signals, such as commonly used binary-DPSK (DBDPSK) and quadrature DPSK (DQPSK) signals, that can achieve optimal receiver sensitivity is described. This approach, which combines filtering and differential phase comparison, can reduce the complexity and cost of DPSK receivers by obviating delay-line interferometer-based demodulation. This can improve receiver stability and reduce size, weight, and power, while maintaining the ability to achieve optimal communications performance. | 05-06-2010 |
20110274429 | METHOD AND APPARATUS FOR PHASE SHIFT KEYED OPTICAL COMMUNICATIONS - A burst-mode differential phase shift keying (DPSK) communications system according to an embodiment of the present invention enables practical, power-efficient, multi-rate communications between an optical transmitter and receiver. An embodiment of the system utilizes a single interferometer in the receiver with a relative path delay that is matched to the DPSK symbol rate of the link. DPSK symbols are transmitted in bursts, and the data rate may be varied by changing the ratio of the burst-on time to the burst-off time. This approach offers a number of advantages over conventional DPSK implementations, including near-optimum photon efficiency over a wide range of data rates, simplified multi-rate transceiver implementation, and relaxed transmit laser line-width requirements at low data rates. | 11-10-2011 |
20120063788 | METHOD AND APPARATUS FOR TRANSMITTING OPTICAL SIGNALS - The present invention addresses the problem of transmitting optical signals with high extinction ratios using low-power drive signals. At present, low-power optical transmitters typically operate with modulation extinction ratios of, at best, about 10 dB. Embodiments of the present invention may achieve extinction ratios exceeding 20 dB using low-power drive signals of under 20 mW at data rates on the order of Gbits/sec. In addition, the modulation may be achieved with both low-power and low-fidelity drive waveforms, enabling conventional and often noisy high-speed, low-power electronics to generate high-extinction, high-fidelity optical waveforms. | 03-15-2012 |
20120281990 | OPTICAL RECEIVER CONFIGURABLE TO ACCOMMODATE A VARIETY OF MODULATION FORMATS - The present invention provides a simple means of demodulating optical signals, e.g. wideband M-ary orthogonal. The demodulator comprises an optical processor and a comparison module. The optical processor transforms M input optical signals into 2 log | 11-08-2012 |
20140016943 | FILTER-BASED DPSK COMMUNICATIONS SYSTEM - A filter-based method of demodulating differentially encoded phase shift keyed (DPSK) optical signals, such as commonly used binary-DPSK (DBDPSK) and quadrature DPSK (DQPSK) signals, that can achieve optimal receiver sensitivity is described. This approach, which combines filtering and differential phase comparison, can reduce the complexity and cost of DPSK receivers by obviating delay-line interferometer-based demodulation. This can improve receiver stability and reduce size, weight, and power, while maintaining the ability to achieve optimal communications performance. | 01-16-2014 |
20160043800 | DESIGN OF A FREE-SPACE OPTICAL COMMUNICATION MODULE FOR SMALL SATELLITES - Communication bottlenecks, particularly in the downlink direction, are a common problem for many CubeSat developers. As described herein, a CubeSat module for a CubeSat comprises an optical transmitter to transmit data to a remote terminal, a receiver to acquire an optical beacon from a remote terminal, and a fine-pointing module operably and directly coupleable to a coarse-pointing module of the CubeSat. The fine-pointing module is configured to point the optical transmitter toward the remote terminal with an accuracy range that overlaps with an accuracy range of the coarse-pointing module of the CubeSat so as to establish a communications link between the CubeSat and the remote terminal over a low-Earth-orbit (LEO) distance. | 02-11-2016 |
Patent application number | Description | Published |
20130073359 | SYSTEM AND METHOD FOR RECEIVING AND APPORTIONING FEES IN AN ONLINE ENVIRONMENT - In one embodiment, a method is provided for receiving and apportioning fees in an online environment comprising a plurality of user accounts of an organization. According to a first step, the organization receives a first payment, which includes one portion for hosting the first user account, a second portion for credits that may be used for online activity, and a third portion for first user discounts that may be used to recruit additional users. In a next step, the organization receives a second payment from a second user recruited by the first user. In an additional step, the organization automatically credits the first user's account in an amount equal to the first user discount redeemed by the second user. | 03-21-2013 |
20130073360 | SYSTEM AND METHOD FOR PRESENTING VIDEO CONTENT IN AN ONLINE ENVIRONMENT - In one embodiment, a method is provided for presenting a plurality of video content in an online environment accessible by a plurality of users. According to a first step, the organization accesses a plurality of content from one or more content providers. In a next step, the organization receives a flowchart for navigating a plurality of playback sequences. The flowchart includes media content modules capable of accessing the content and decision modules for selecting a subset of media content modules. In an additional step, the organization presents a graphical representation of the playback sequences. In a further step, the organization uses a content ranking engine for delivering at least a portion of the playback sequences. | 03-21-2013 |
Patent application number | Description | Published |
20090270815 | Catheter Priming System - A catheter includes a longitudinally extending catheter body having proximal and distal ends. The catheter body defines a lumen extending longitudinally from a first port defined at the proximal end, through the body, to a second port defined at the distal end. The catheter includes a valve for controlling fluid flow through the second port. | 10-29-2009 |
20100022891 | INTRALUMINAL SPECTROSCOPE WITH WALL CONTACTING PROBE - A spectroscope for detecting vulnerable plaque within a lumen defined by an intraluminal wall includes a probe through which an optical fiber extends. An coupler in optical communication with the fiber is configured to atraumatically contact the intraluminal wall. A light source provides light to the fiber for illuminating the wall and a detector coupled to the fiber receives light from within the wall. | 01-28-2010 |
20130345670 | DEVICES AND METHODS FOR THE TREATMENT OF TISSUE - Systems, methods and devices for the treatment of tissue are disclosed. A system includes an elongate tube with a distal portion. A treatment element is positioned on the elongate tube distal portion, the treatment element constructed and arranged to treat target tissue. In one embodiment, gastrointestinal tissue is modified for the treatment of diabetes. | 12-26-2013 |
20140371736 | HEAT ABLATION SYSTEMS, DEVICES AND METHODS FOR THE TREATMENT OF TISSUE - A system for treatment target tissue comprises an ablation device and an energy delivery unit. The ablation device comprises an elongate tube with an expandable treatment element. The system delivers a thermal dose of energy to treat the target tissue. Methods of treating target tissue are also provided. | 12-18-2014 |
20150045825 | TISSUE EXPANSION DEVICES, SYSTEMS AND METHODS - A device for expanding tissue comprises at least one fluid delivery tube and at least one fluid delivery element in fluid communication with the at least one fluid delivery tube. The at least one fluid delivery tube comprises a proximal end, a distal end, and a lumen therebetween. The device is constructed and arranged to perform a near full circumferential expansion of luminal wall tissue. Systems and methods are also provided, including a system for expanding tissue layers and treating tissue proximate to the expanded tissue layers. | 02-12-2015 |
20150141987 | ELECTRICAL ENERGY ABLATION SYSTEMS, DEVICES AND METHODS FOR THE TREATMENT OF TISSUE - A device for ablating target tissue of a patient with electrical energy is provided. An elongate shaft includes a proximal portion and a distal portion, and a radially expandable element is attached to the distal portion. An ablation element for delivering electrical energy to target tissue is mounted to the radially expandable element. The device can be constructed and arranged to ablate the duodenal mucosa of a patient while avoiding damage to the duodenal adventitial tissue. Systems and methods of treating target tissue are also provided. | 05-21-2015 |
20150148738 | ABLATION SYSTEMS, DEVICES AND METHODS FOR THE TREATMENT OF TISSUE - A device for ablating target tissue of a patient with an ablative fluid is provided. An elongate shaft includes a proximal portion and a distal portion, and at least one fluid delivery element is attached to the distal portion. The device can be configured to ablate the duodenal mucosa of a patient while avoiding damage to the duodenal adventitial tissue. Systems and methods of treating target tissue are also provided. | 05-28-2015 |
20160081745 | METHODS, SYSTEMS AND DEVICES FOR REDUCING THE LUMINAL SURFACE AREA OF THE GASTROINTESTINAL TRACT - Methods, systems and devices for treating a patient include providing a tissue treatment element constructed and arranged to deliver energy to tissue and treating tissue of the gastrointestinal tract by causing the tissue treatment element to deliver energy to an energy delivery zone. Treatment results in a reduction in the luminal surface area of at least a portion of the gastrointestinal tract. In particular embodiments, the methods, systems and devices are used to treat diabetes. | 03-24-2016 |
Patent application number | Description | Published |
20110280729 | AXIAL-FLOW FAN - A fan includes a hub and blades. A first edge of each blade is proximate an open end of the hub. A first rib is coupled to the hub and substantially aligned with a first plane intersecting the central axis and an intersection of the first edge of the first blade with the hub. The first plane is angularly spaced from a reference plane intersecting the central axis and an intersection of the first edge of the second blade with the hub. An angular spacing between the first plane and the reference plane defines one sector. A second rib is aligned with a second plane angularly positioned between the first plane and the reference plane at a location less than or equal to about (1/nR−0.05) sectors from the first plane, in which nR equals the number of ribs divided by the number of blades. | 11-17-2011 |
20120301329 | Airflow Assembly having Improved Acoustical Performance - An airflow assembly, includes a plenum, a barrel, a fan support, a fan assembly, and a plurality of ribs. The plenum includes an opening structure defining a plenum opening. The barrel extends in a downstream direction from the opening structure, and defines a barrel space and a downstream edge. The fan support is at least partially positioned within the barrel space. The fan assembly is supported by the fan support and includes (i) a motor and (ii) a blade assembly configured to rotate about an axis. Each of the ribs extends between (i) the opening structure or the barrel and (ii) the fan support. The downstream direction is parallel to the axis. An upstream direction is opposite of the downstream direction and parallel to the axis. A plane intersects the axis and is perpendicular to the axis. | 11-29-2012 |
20120321474 | Airflow Assembly having Improved Acoustical Performance - An airflow assembly includes a fan, a shroud, a plurality of ribs, and a fan support. The fan has a number of fan blades. The shroud includes (i) a plenum defining a plenum opening located adjacent to the number of fan blades, and (ii) a barrel extending from the plenum so as to surround the plenum opening. The plenum further defines at least one airflow opening spaced apart from the plenum opening. Each of the plurality of ribs extends inwardly from the barrel. The fan support is attached to the plurality of ribs and is configured to support the fan. The at least one airflow opening is not an attachment structure or a guiding structure, is not configured to receive a fastening member, and does not function as a water drain. | 12-20-2012 |
20140056701 | FAN SHROUD WITH COMPLEMENTARY TWO-SIDED RIBBING - A fan shroud has a panel including a first surface and a second surface substantially opposite the first surface. A first rib extends substantially perpendicularly from the first surface, and the first rib has an area of discontinuity where a height of the first rib is reduced. A second rib extends substantially perpendicularly from the second surface, and the second rib is substantially aligned with the first rib and positioned substantially opposite the area of discontinuity of the first rib. | 02-27-2014 |
Patent application number | Description | Published |
20100104503 | MODULAR NANOPARTICLES FOR ADAPTABLE VACCINES - Modular nanoparticle vaccine compositions and methods of making and using the same have been developed. Modular nanoparticle vaccine compositions comprise an antigen encapsulated in a polymeric particle and adaptor elements which modularly couple functional elements to the particle. The modular design of these vaccine compositions, which involves flexible addition and subtraction of antigen, adjuvant, immune potentiators, molecular recognition and transport mediation elements, as well as intracellular uptake mediators, allows for exquisite control over variables that are important in optimizing an effective vaccine delivery system. | 04-29-2010 |
20100166802 | METHODS AND REAGENTS FOR DECREASING CLINICAL REACTION TO ALLERGY - The present invention provides methods and compositions for treating or preventing allergic reactions, particularly anaphylactic reactions. Methods of the present invention involve administering microorganisms to allergic subjects, where the microorganisms contain a recombinant version of the protein allergen. The recombinant version can be wild-type or may include mutations within IgE epitopes of the protein allergen. Preferably the compositions are administered rectally. Particularly preferred microorganisms are bacteria such as | 07-01-2010 |
20110027298 | MICROBIAL DELIVERY SYSTEM - The present invention provides methods and compositions for treating or preventing allergic responses, particularly anaphylactic allergic responses, in subjects who are allergic to allergens or susceptible to allergies. Methods of the present invention utilize administration of microorganisms to subjects, where the microorganisms produce allergens and protect the subjects from exposure to the allergens until phagocytosed by antigen-presenting cells. Particularly preferred microorganisms are gram-negative bacteria, gram-positive bacteria, and yeast. Particularly preferred allergens are proteins found in foods, venoms, drugs and latex that elicit allergic reactions and anaphylactic allergic reactions in individuals who are allergic to the proteins or are susceptible to allergies to the proteins. The proteins may also be modified to reduce the ability of the proteins to bind and crosslink IgE antibodies and thereby reduce the risk of eliciting anaphylaxis without affecting T-cell mediated Th1-type immunity. | 02-03-2011 |
20120283421 | METHODS AND REAGENTS FOR DECREASING CLINICAL REACTION TO ALLERGY - It has been determined that allergens, which are characterized by both humoral (IgE) and cellular (T-cell) binding sites, can be modified to be less allergenic by modifying the IgE binding sites. The IgE binding sites can be converted to non-IgE binding sites by altering as little as a single amino acid within the protein, preferably a hydrophobic residue towards the center of the IgE epitope, to eliminate IgE binding. Additionally or alternatively a modified allergen with reduced IgE binding may be prepared by disrupting one or more of the disulfide bonds that are present in the natural allergen. The disulfide bonds may be disrupted chemically, e.g., by reduction and alkylation or by mutating one or more cysteine residues present in the primary amino acid sequence of the natural allergen. In certain embodiments, modified allergens are prepared by both altering one or more linear IgE epitopes and disrupting one or more disulfide bonds of the natural allergen. In certain embodiments, the methods of the present invention allow allergens to be modified while retaining the ability of the protein to activate T-cells, and, in some embodiments by not significantly altering or decreasing IgG binding capacity. The Examples provided herein use peanut allergens to illustrate applications of the invention. | 11-08-2012 |
20130142817 | MICROBIAL DELIVERY SYSTEM - The present invention provides methods and compositions for treating or preventing allergic responses, particularly anaphylactic allergic responses, in subjects who are allergic to allergens or susceptible to allergies. Methods of the present invention utilize administration of microorganisms to subjects, where the microorganisms produce allergens and protect the subjects from exposure to the allergens until phagocytosed by antigen-presenting cells. Particularly preferred microorganisms are gram-negative bacteria, gram-positive bacteria, and yeast. Particularly preferred allergens are proteins found in foods, venoms, drugs and latex that elicit allergic reactions and anaphylactic allergic reactions in individuals who are allergic to the proteins or are susceptible to allergies to the proteins. The proteins may also be modified to reduce the ability of the proteins to bind and crosslink IgE antibodies and thereby reduce the risk of eliciting anaphylaxis without affecting T-cell mediated Th1-type immunity. | 06-06-2013 |
20130243814 | MICROBIAL DELIVERY SYSTEM - The present invention provides methods and compositions for treating or preventing allergic responses, particularly anaphylactic allergic responses, in subjects who are allergic to allergens or susceptible to allergies. Methods of the present invention utilize administration of microorganisms to subjects, where the microorganisms produce allergens and protect the subjects from exposure to the allergens until phagocytosed by antigen-presenting cells. Particularly preferred microorganisms are gram-negative bacteria, gram-positive bacteria, and yeast. Particularly preferred allergens are proteins found in foods, venoms, drugs and latex that elicit allergic reactions and anaphylactic allergic reactions in individuals who are allergic to the proteins or are susceptible to allergies to the proteins. The proteins may also be modified to reduce the ability of the proteins to bind and crosslink IgE antibodies and thereby reduce the risk of eliciting anaphylaxis without affecting T-cell mediated Th1-type immunity. | 09-19-2013 |
20150125384 | MODULAR NANODEVICES FOR SMART ADAPTABLE VACCINES - Modular nanoparticle vaccine compositions and methods of making and using the same have been developed. Modular nanoparticle vaccine compositions comprise an antigen encapsulated in a polymeric particle and adaptor elements which modularly couple functional elements to the particle. The modular design of these vaccine compositions, which involves flexible addition and subtraction of antigen, adjuvant, immune potentiators, molecular recognition and transport mediation elements, as well as intracellular uptake mediators, allows for exquisite control over variables that are important in optimizing an effective vaccine delivery system. | 05-07-2015 |
20150174225 | NANOPARTICLES FOR TREATMENT OF ALLERGY - The present invention encompasses the surprising finding that nanoparticle compositions can have beneficial effects on allergy even when prepared without a known specific allergy therapeutic. The present invention provides such nanoparticle compositions. In some embodiments, provided nanoparticles are associated with functional elements that cause the nanoparticles to mimic bacterial cells. The present invention encompasses the surprising finding that provided nanoparticles may be useful for treatment and/or prevention of multiple different allergies in a single patient. The present invention encompasses the recognition that provided empty nanoparticles may be useful as a “pan-allergy” therapeutic and/or vaccine. | 06-25-2015 |
Patent application number | Description | Published |
20150310351 | PROFILING A POPULATION OF EXAMPLES - A method for profiling a population of examples includes a computer receiving a dataset representative of the population of examples, a user selection of a population constraint, and an indication of a goal. The computer generates shallow fixed-depth trees based on the dataset and determines a collection of leaves of the shallow fixed-depth trees meeting the population constraint. Next, the computer sorts the collection of leaves based on a degree to which the goal is met. Then, the computer creates one or more profiles based on the collection of leaves. | 10-29-2015 |
20150363693 | ARCHITECTURE AND METHODOLOGY FOR PERFORMING REAL-TIME AUTONOMOUS ANALYTICS OVER MULTIPLE ACTUAL AND VIRTUAL DEVICES - A device for performing autonomous analytics comprises one or more adaptors, device hierarchy data, and an analytic executive. The adaptors are configured to adapt data streams from one or more heterogeneous data sources into a tagged dataset. The device hierarchy data comprises an identification of one or more hierarchical relationships between the device and one or more additional devices. The analytic executive is configured to identify a plurality of relevant devices based on the device hierarchy data and collect device data from each of the plurality of relevant devices. The analytic executive is further configured to generate a collection of analytic models using the collected device data, score one or more new data items included in the tagged dataset using the collection of analytic models, yielding scored results, and use one or more business rules to trigger an action based on the scored results. | 12-17-2015 |
20160042292 | AUTOMATED METHODOLOGY FOR INDUCTIVE BIAS SELECTION AND ADAPTIVE ENSEMBLE CHOICE TO OPTIMIZE PREDICTIVE POWER - A computer-implemented method of automating inductive bias selection includes a computer receiving a plurality of examples, each example providing a plurality of feature-value pairs. The computer constructs an inductive bias dataset which correlates each respective example in the plurality of examples with numerical indications of training quality. The numerical indications of training quality for each respective example are generated by creating a plurality of models, with each model corresponding to a distinct set of inductive biases. The training quality for each respective model is evaluated when applied to the respective example. The computer uses the inductive bias dataset to select a plurality of inductive biases for application to one or more new datasets. | 02-11-2016 |
Patent application number | Description | Published |
20120129766 | METHODS OF TREATING FGF21-ASSOCIATED DISORDERS - The invention relates to the identification of new polypeptide and protein variants of fibroblast growth factor 21 (FGF21) that have improved pharmaceutical properties. Also disclosed are methods for treating FGF21-associated disorders, including metabolic conditions. | 05-24-2012 |
20130079500 | FUSION PROTEINS FOR TREATING METABOLIC DISORDERS - The invention relates to the identification of fusion proteins comprising polypeptide and protein variants of fibroblast growth factor 21 (FGF21) with improved pharmaceutical properties. Also disclosed are methods for treating FGF21-associated disorders, including metabolic conditions. | 03-28-2013 |
20130129724 | DUAL FUNCTION PROTEINS FOR TREATING METABOLIC DISORDERS - The present invention relates to the identification of new proteins comprising fibroblast growth factor 21 (FGF21) and other metabolic regulators, including variants thereof, known to improve metabolic profiles in subjects to whom they are administered. Also disclosed are methods for treating FGF21-associated disorders, GLP-1-associated disorders, and Exendin-4-associated disorders, including metabolic conditions. | 05-23-2013 |
20160051628 | METHODS OF TREATING FGF21-ASSOCIATED DISORDERS - The invention relates to the identification of new polypeptide and protein variants of fibroblast growth factor 21 (FGF21) that have improved pharmaceutical properties. Also disclosed are methods for treating FGF21-associated disorders, including metabolic conditions. | 02-25-2016 |