52nd week of 2013 patent applcation highlights part 53 |
Patent application number | Title | Published |
20130345345 | Process for Making Particulate-Free Poly(Phenylene Ether) Compositions and Photovoltaic Backsheet Materials Derived Therefrom - The present invention is directed to a process for preparing halogen-free melt-filtered polymer compositions, compositions prepared by the process, as well as articles derived therefrom. The process comprises filtering the melted composition through a filter to remove particulate impurities that are 0.5 mm | 2013-12-26 |
20130345346 | CYCLOALIPHATIC POLYPHOSPHITE POLYMER STABILIZERS - A polymeric polyphosphite and copolymeric polyphosphite is described which contains a cycloaliphatic moiety, preferably cyclohexane dimethanol, in the polyphosphite backbone chain. | 2013-12-26 |
20130345347 | Polycarbonate Compositions with Improved Impact Resistance - The present disclosure relates to thermoplastic polycarbonate compositions comprising a first polycarbonate component, a second polycarbonate component comprising an isosorbide/resorcinol/bisphenol-A polycarbonate terpolymer, and at least one impact modifier. The disclosed compositions have, among other characteristics, improved Notched Izod Impact strength, tensile modulus, tensile strength, and multi-axial impact strength. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 2013-12-26 |
20130345348 | PROCESS FOR PREPARING A MASTERBATCH IN THE LIQUID PHASE - The invention relates to a process for the preparation of a masterbatch in the liquid phase based on one or more diene elastomer latexes and on one or more fillers, comprising the following successive stages:
| 2013-12-26 |
20130345349 | THERMOPLASTIC RESIN COMPOSITION COMPRISING A MIXTURE OF SLIP AGENTS AND A MONO-OR CO-EXTRUDED, LAMINATED OR NON-LAMINATED FILM - The purpose of the present invention is to propose a composition of slip additive agents for use in thermoplastic resins, preferably polyolefins, and consequently the presence of this composition on at least one of the layers of mono-extruded or coextruded, laminated or non-laminated films. More particularly, the invention comprehends a composition of additives which comprises at least one primary amide of the generic formula R—CO—NH | 2013-12-26 |
20130345350 | POLYMER COMPOSITIONS, POLYMER FILMS, AND METHODS FOR FORMING SAME - Stable, high performance polymer compositions including polybenzimidazole (PBI) and a melamine-formaldehyde polymer, such as methylated, poly(melamine-co-formaldehyde), for forming structures such as films, fibers and bulky structures. The polymer compositions may be formed by combining polybenzimidazole with the melamine-formaldehyde polymer to form a precursor. The polybenzimidazole may be reacted and/or intertwined with the melamine-formaldehyde polymer to form the polymer composition. For example, a stable, free-standing film having a thickness of, for example, between about 5 μm and about 30 μm may be formed from the polymer composition. Such films may be used as gas separation membranes and may be submerged into water for extended periods without crazing and cracking. The polymer composition may also be used as a coating on substrates, such as metal and ceramics, or may be used for spinning fibers. Precursors for forming such polymer compositions are also disclosed. | 2013-12-26 |
20130345351 | FLAMEPROOFING - The invention relates to an inorganic, halogen-free flameproofing agent made of modified, rehydrated red mud (MR2S), having a mineral composition of 10 to 50 weight percent of iron compounds, 12 to 35 weight percent of aluminum compounds, 5 to 17 weight percent of silicon compounds, 2 to 21 weight percent of TiO | 2013-12-26 |
20130345352 | Benzoxazine Resins - A curable polymer composition containing: (A) a thermoset benzoxazine resin precursor component; (B) optionally, an arylsulphone-containing benzoxazine component, and (C) a polyarylsulphone thermoplastic toughening agent, wherein in the absence of component (B), component (C) contains one or more benzoxazine pendant-and/or end-groups. | 2013-12-26 |
20130345353 | THERMOPLASTIC MOLDING COMPOUNDS ON THE BASIS OF STYRENE COPOLYMERS AND POLYAMIDES HAVING IMPROVED LOW-TEMPERATURE TOUGHNESS - The invention relates to thermoplastic molding compounds, containing a) 3 to 91.9 wt % of one or more styrene copolymers as component A, b) 3 to 91 wt % of one or more polyamides as component B, c) 3 to 50 wt % of one or more graft natural rubbers as component C, d) 0.1 to 25 wt % of one or more compatibilizers as component D, and e) 2 to 30 wt % of ethylene-1-octene copolymer having functional groups as component E, said thermoplastic molding compounds having improved low-temperature toughness. | 2013-12-26 |
20130345354 | MOISTURE-CURABLE HOT MELT ADHESIVE - A moisture-curable hot melt adhesive including a urethane prepolymer having an isocyanate group at the end, and an acrylic polymer (A) having an alicyclic structure, wherein the urethane prepolymer has a chemical structure derived from a crystalline polyesterpolyol. The moisture-curable hot melt adhesive is excellent in initial adhesive strength and excellent in heat resistance. The acrylic polymer (A) may be a chemical structure derived from at least one of (meth)acrylic acid derivatives selected from cyclohexyl (meth)acrylate and isobornyl (meth)acrylate. | 2013-12-26 |
20130345355 | HOT MELT ADHESIVE - The present invention provides a hot melt adhesive which is less likely to cause stringing, is excellent in heat resistance and thermal stability, and has excellent adhesive strength in a wide temperature range. Moreover, the present invention provides a paper product produced by using the hot melt adhesive. | 2013-12-26 |
20130345356 | ROOM TEMPERATURE CURED VINYL SILAZANE COMPOSITIONS - A polysilazane composition, formulated from a vinyl silazane and an organometallic accelerator, and associated methods thereof. | 2013-12-26 |
20130345357 | Composition for Use as an Assay - A composition for use as an assay reagent comprises a solid support comprising a member of a signal producing system and a coating of a synthetic copolymer. The synthetic copolymer comprises a first polymerized monomer comprising a pendant moiety comprising a reactive functionality or a derivative of a reactive functionality and a second polymerized monomer comprising a pendant moiety comprising at least 1 carbon atoms and at least 2 heteroatoms. In some embodiments the copolymer comprises a polyethylenic backbone comprising the pendant moiety comprising a reactive functionality or a derivative of a reactive functionality and the pendant moiety comprising at least 1 carbon atom and at least 2 heteroatoms. | 2013-12-26 |
20130345358 | USE OF BRANCHED ADDITION COPOLYMERS IN CURING SYSTEMS - The present invention relates to the use of branched addition copolymers in systems which can be cured post synthesis to form for example polymer coatings, sealants, inks, adhesives or composites and also relates to methods of preparing the cured systems, compositions comprising such copolymers and the use of the compositions in for example but not limited to coatings, inks, sealants, adhesives or composites. | 2013-12-26 |
20130345359 | CURABLE RESIN COMPOSITION, HARDENED MATERIAL THEREOF, AND OPTICAL SEMICONDUCTOR APPARATUS - A curable resin composition to which at least phosphor particles and nanoparticles having a primary particle size of 1 nm or more and less than 100 nm are added, wherein the nanoparticles are dispersed in the form of secondarily aggregated particles having an average particle size of 100 nm or more and 20 μm or less in terms of volume Q3 is provided for an optical semiconductor apparatus in which when a sealant obtained by dispersing phosphor particles in a curable resin composition having a low viscosity is filled into a package substrate, the dispersion state of the phosphor particles is not changed at the early and late stages of the fabrication, specifically the amounts of the phosphor particles to be contained at the early and late stages are the same, and the color rendering property can be stably maintained, a hardened material thereof, and an optical semiconductor apparatus. | 2013-12-26 |
20130345360 | PROCESS FOR PREPARING POLYETHYLENE BLEND COMPRISING METALLOCENE PRODUCED RESINS AND CHROMIUM PRODUCED RESINS - A process for preparing a homogeneous polyethylene product can include producing a first polyethylene resin in the presence of a metallocene catalyst in a reactor. The first polyethylene resin can have a density of from 0.942 to 0.970 g/cm | 2013-12-26 |
20130345361 | PROCESS FOR PREPARING POLYOLEFIN BLENDS IN A DEVICE FOR CONTINUOUSLY PHYSICALLY MELTING AND BLENDING THE BLENDS - A process for preparing a polyolefin product can include providing a first high molecular weight (HMW) polyolefin resin having an HLMI of between 0.01 and 5 g/10 min, and separately providing a second low molecular weight (LMW) polyolefin resin having an MI | 2013-12-26 |
20130345362 | ACRYLIC RUBBER GRAFT COPOLYMER AND THERMOPLASTIC RESIN COMPOSITION - [Object] To provide acrylic rubber graft copolymers capable of giving thermoplastic resin compositions exhibiting excellent impact resistance, rigidity and appearance, and to provide thermoplastic resin compositions including the acrylic rubber graft copolymers. | 2013-12-26 |
20130345363 | BIODEGRADABLE IMPACT-MODIFIED POLYMER COMPOSITIONS - The invention relates to an impact-modified bio-degradable polymer composition having large particle size impact modifiers dispersed in a continuous biodegradable polymer phase. The impact modifiers have a core-shell morphology and may have average sizes of greater than 250 nm. The impact-modified composition has good impact properties and low haze, The biodegradable polymer is preferably a polylactide or polyhydroxy butyrate. The composition comprises 30-99.9 weight percent of degradable polymer and 0.1 to 15 weight percent of one or more impact modifiers. | 2013-12-26 |
20130345364 | METHOD OF MAKING SILICONE CONTAINING CONTACT LENS WITH REDUCED AMOUNT OF DILUENTS - The present invention relates to a method of manufacturing a contact lens including the steps of: (i) adding reactive components to a mold, wherein the reactive components comprise (a) at least one hydroxy-containing silicone component having a weight average molecular weight from about 200 to about 15,000 g/mole and (b) at least one mono-ether terminated, mono-methacrylate terminated polyethylene glycol having a weight average molecular weight from about 200 to about 10,000 g/mole; (ii) curing the reactive components within the mold to form the contact lens; and (iii) removing the contact lens from said mold. | 2013-12-26 |
20130345365 | CURABLE FLUOROELASTOMER COMPOSITION - Fluoroelastomer compositions comprising fluoroelastomers having copolymerized units of a nitrile-containing cure site monomer are cured with certain phenol hydrazine complex curatives. | 2013-12-26 |
20130345366 | PARTIALLY HYDROGENATED NITRILE RUBBERS - Provided are new partially hydrogenated nitrile rubbers which are distinguished by a specific ratio of viscosity to molecular weight, and also vulcanizable mixtures and vulcanizates based on said rubbers, and also the associated preparation processes. The partially hydrogenated nitrile rubbers lead to compounded formulations having advantageous processing properties in conjunction with excellent vulcanizate properties. | 2013-12-26 |
20130345367 | METHODS FOR PREPARATION OF NOVEL GRAFT COPOLYMERS - The present invention relates to novel graft copolymers of functionalized poly(isoolefin-co-conjugated diolefin, and a process of preparing such graft copolymers. The present invention also relates to a method of preparing functionalized copolymers of isoolefins and conjugated diolefins. | 2013-12-26 |
20130345368 | Fluoropolymer Resin Treatment Employing Melt Extrusion and Exposure to Oxygen Source to Reduce Discoloration - Process for reducing thermally induced discoloration of melt-processible fluoropolymer resin produced by polymerizing fluoromonomer in an aqueous medium to form aqueous fluoropolymer dispersion and isolating said fluoropolymer from said aqueous medium to obtain said fluoropolymer resin. The process comprises:
| 2013-12-26 |
20130345369 | Biodegradable Photoluminescent Polymers - The present invention describes a novel clastomeric biodegradable photoluminescent polymer (BPLP). The BPLPs of the present invention possess great processability and tunable fluorescence emission characteristics and are cell-compatible and biodegradable. The BPLPs of the present invention can serve as both implant materials and bioimaging probes. | 2013-12-26 |
20130345370 | SILICONE RESIN COMPOSITION - A first silicone resin composition is prepared by allowing an organopolysiloxane containing silanol groups at both ends containing silanol groups at both ends of a molecule and a silicon compound containing, in one molecule, at least two leaving groups leaving by a condensation reaction with the silanol groups to undergo the condensation reaction in the presence of a condensation catalyst. The silicon compound contains a trifunctional silicon compound containing, in one molecule, the three leaving groups and a bifunctional silicon compound containing, in one molecule, the two leaving groups. | 2013-12-26 |
20130345371 | MICHAEL ADDITION CURING CHEMISTRIES FOR SULFUR-CONTAINING POLYMER COMPOSITIONS - The use of Michael addition curing chemistries in compositions comprising sulfur-containing polymers such as polythioethers and polysulfides useful in aerospace sealant applications are disclosed. Sulfur-containing adducts comprising terminal Michael acceptor groups are also disclosed. | 2013-12-26 |
20130345372 | POLYFUNCTIONAL SULFUR-CONTAINING EPOXIES AND COMPOSITIONS THEREOF - Disclosed are polyfunctional sulfur-containing epoxies and compositions containing polyfunctional sulfur-containing epoxies. The polyfunctional sulfur-containing epoxies may be used as a curing agent and combined with polythioethers and/or polysulfides used to provide high elongation sealants useful in aerospace applications. | 2013-12-26 |
20130345373 | Methods for Terminating Olefin Polymerizations - Catalyst deactivating agents and compositions containing catalyst deactivating agents are disclosed. These catalyst deactivating agents can be used in methods of controlling polymerization reactions, methods of terminating polymerization reactions, methods of operating polymerization reactors, and methods of transitioning between catalyst systems. | 2013-12-26 |
20130345374 | Double Loop Technology - A method for the copolymerization of ethylene and a C | 2013-12-26 |
20130345375 | OLEFIN POLYMERIZATION CATALYST COMPOSITION AND OLEFIN POLYMERIZATION PROCESS USING THE SAME - The olefin polymerization catalyst composition comprises an organometallic compound represented by Formula 1; an organic transition metal compound represented by Formula 2; an organic transition metal compound represented by Formula 3; and an aluminoxane. | 2013-12-26 |
20130345376 | Aluminoxane Catalyst Activators Containing Carbocation Agents, and use thereof in Polyolefin Catalysts - This invention relates to an activator composition comprising (i) an organoaluminum compounds; (ii) a carbocation compound of the formula R | 2013-12-26 |
20130345377 | Ethylene Copolymers, Film and Polymerization Process - Ethylene copolymers having a relatively high melt flow ratio and a multimodal profile in a temperature rising elution fractionation (TREF) plot are disclosed. The copolymers can be made into film having good dart impact values and good stiffness properties under decreased extruder pressures. | 2013-12-26 |
20130345378 | METALLOCENE COMPOUND, CATALYST COMPOSITION INCLUDING THE SAME, AND OLEFIN POLYMERIZATION PROCESS USING THE SAME - A metallocene compound is represented by the following formula, | 2013-12-26 |
20130345379 | High Styrene High Vinyl Styrene-Butadiene Rubber and Methods for Preparation Thereof - A process for polymerization of a polymer containing monomeric units derived from a styrene monomer and a 1,3-butadiene monomer includes polymerizing the monomeric units in the presence of an initiator, a first polar agent, and a second polar agent. The first polar agent includes a structure (I): R | 2013-12-26 |
20130345380 | NOVEL INITIATION PROCESS FOR POLYMERIZATION WITH ACTIVATION USING IONIC LIQUIDS - The present invention relates to an innovative polymerization technique for (meth)acrylates and styrenes, in which the polymerization is initiated by isocyanates and special bases with imine structure and is activated/accelerated by addition of ionic liquids. With this new technique, which can be employed selectively, it is also possible to produce high molecular weight poly(meth)acrylates with in some cases narrow molecular weight distribution. | 2013-12-26 |
20130345381 | SYNTHESIS OF MAKING 2,3,3,3-TETRAFLUOROPROPENE CONTAINING FLUOROPOLYMERS - The invention relates to a method for synthesizing 2,3,3,3-tetrafluoropropene containing fluoropolymers using non-fluorinated surfactants in an emulsion process. No fluorinated surfactants are used in the process, and a persulfate initiator is used as the primary initiator. The process produces high molecular weight copolymers. | 2013-12-26 |
20130345382 | NORBORNENE-TYPE FORMATE MONOMERS AND POLYMERS AND OPTICAL WAVEGUDIES FORMED THEREFROM - This invention discloses and claims a series of polycyclic monomers and polymers useful in the production of optical waveguides. The polymers of the invention comprise one or more repeating units represented by the formula (IV): | 2013-12-26 |
20130345383 | BIO-BASED BRANCHED AND HYPERBRANCHED POLYMERS AND OLIGOMERS - Branched and hyperbranched oligomers and polymers that contain a cashew nutshell oil or liquid component are provided. The novel oligomers and polymers are suitable for use as an oil, lubricant, coating, adhesive, resin or composite. | 2013-12-26 |
20130345384 | ULTRASONIC-ASSISTED MOLDING OF PRECISELY-SHAPED ARTICLES AND METHODS - An ultrasonic-assisted injection molding system and method for making precisely-shaped articles. A source of ultrasonic energy is positioned to apply vibrational energy to a mold cavity connected to at least one gate in flow communication with a source of molten (co)polymer. The mold is heated to a temperature of 104-116° C., and the molten (co)polymer is injected into the mold cavity. After cooling the mold until the molten (co)polymer within the gate has solidified, ultrasonic energy is applied to the mold without remelting the solidified (co)polymer within the gate until the temperature increases to 116-122° C., thereby substantially relieving flow induced stresses. The mold is then cooled until the temperature decreases to 101-107° C., and is thereafter heated until the temperature increases to 116-122° C., thereby substantially relieving any thermally induced stresses. The mold is cooled until the molten (co)polymer has solidified, thereby forming a precision molded plastic optical element. | 2013-12-26 |
20130345385 | PROCESS FOR PRODUCING A COMPOSITE MATERIAL - The present invention relates to a process for producing a composite material composed of
| 2013-12-26 |
20130345386 | Polyetheramine Macromonomers Comprising Two Neighboring Hydroxyl Groups And Their Use For Producing Polyurethanes - The object of the invention are compounds of the formula (2) wherein R | 2013-12-26 |
20130345387 | METHOD FOR PRODUCING POLYESTER, AND FLUORINE-CONTAINING DICARBOXYLIC ACID ESTER COMPOUND - The present invention relates to a method for producing a polyester, containing conducting a transesterification reaction of at least one compound selected from compounds represented by the following formulae (1) to (3) with a diol compound in the presence of a catalyst: | 2013-12-26 |
20130345388 | Process for Producing Nitrile-Fatty Acid Compounds - The invention relates to a process for synthesizing a nitrile-fatty acid (heminitrile) from unsaturated fatty acids, in the form of an acid or a simple ester or a “complex” ester of triglyceride type, which is first of all converted into an unsaturated fatty nitrile which is subjected to oxidative cleavage using H | 2013-12-26 |
20130345389 | CONTROLLED RELEASE AMINE-CATALYZED, MICHAEL ADDITION-CURABLE SULFUR-CONTAINING POLYMER COMPOSITIONS - Compositions comprising sulfur-containing polymers such as polythioethers, Michael acceptors, and controlled release amine catalysts employing Michael addition curing chemistries useful in aerospace sealant applications are disclosed. The compositions exhibit extended pot life and the rate of curing can be tailored for specific applications. | 2013-12-26 |
20130345390 | WATERBASED DIMERIZED ROSINS AND THE PROCESS TO MAKE THEM - The present invention relates to a method to prepare dimerized rosins dispersible in water in presence of extremely low level of dimerization acid catalyst. The present invention relates also to its use as a tackifier resin, solid or in water, and ink resin, and an adhesive composition and ink composition comprising the rosin resin. | 2013-12-26 |
20130345391 | Composite Probes and Use Thereof in Super Resolution Methods - Composite probes for super resolution optical techniques using super resolution via transiently activated quenchers (STAQ) include a donor moiety and an acceptor moiety joined by a linker, wherein the acceptor moiety, when excited by incident radiation, is excited to a state which, for example, absorbs in the donor emission region, such that the acceptor moiety in its excited state quenches at least a portion of the donor moiety emission. Other transiently activated quenching mechanisms and moieties could accomplish the same task by reducing donor population. Also disclosed are methods for irradiating a selected region of a target material including the composite probe, wherein the composite probe enables improved resolution by point spread function modification and/or nanoscale chemical reactions. | 2013-12-26 |
20130345392 | EDN3-LIKE PEPTIDES AND USES THEREOF - This application discloses novel EDN3-like polypeptides. One such short polypeptide is EDN3 97-140, which is a 44 amino acid peptide that stimulates GLP-1 secretion in enteric cells and inhibits gluconeogenesis in hepatic cells. EDN3 97-140, as well as other EDN3-like polypeptides provided herein may be used in the study and treatment of a number of indications, including the treatment of metabolic disorders such as obesity and diabetes. | 2013-12-26 |
20130345393 | NOVEL CROSS-LINKED PEPTIDES CONTAINING NON-PEPTIDE CROSS-LINKED STRUCTURE, METHOD FOR SYNTHESIZING CROSS-LINKED PEPTIDES, AND NOVEL ORGANIC COMPOUND USED IN METHOD - The purpose of the present invention is to provide a cross-linked peptide containing a novel non-peptide cross-linked structure, and a method for synthesizing the same. A cross-linked peptide having a novel non-peptide cross-linked structure, a useful intermediate for synthesizing the cross-linked peptide, and a method for synthesizing the novel cross-linked peptide and the intermediate are provided. The cross-linked peptide is characterized by having an —NR— bond in the cross-linked structure. By using the method for synthesizing the cross-linked peptide, a cross-link can be freely designed and an change can be freely made to a cross-link. | 2013-12-26 |
20130345394 | NOVEL NPR-B AGONISTS - Disclosed are novel compounds having NPR-B agonistic activity. Preferred compounds are linear peptides containing 8-13 conventional or non-conventional L- or D-amino acid residues connected to one another via peptide bonds. | 2013-12-26 |
20130345395 | SYNTHESIS OF BETA-TURN PEPTIDOMIMETIC CYCLIC COMPOUNDS - The present invention relates to methods of preparing β-turn cyclic peptidomimetic compounds and intermediates thereof. Particularly, the present invention relates to a process for the synthesis of β-turn cyclic peptidomimetic compounds of formula I: | 2013-12-26 |
20130345396 | ANGIOTENSIN CONVERTING ENZYME INHIBITORY PEPTIDE - To provide ACE inhibitory peptides which can effectively inhibit ACE by a small amount of ingestion and have no fear of causing side effects and which can be orally ingested easily during daily life by persons having high blood pressure, and compositions comprising the peptides. The peptides represented by the following structural formulae (1) to (9), and salts thereof are provided. (1) Asp-Arg-Pro, (2) Asn-Trp, (3) Val-Gly-Leu, (4) Ile-Gly-Val, (5) Gly-Val-Pro, (6) Ile-Pro-Tyr, (7) pyroGlu-Pro, (8) Tyr-Thr, (9) Pro-Trp | 2013-12-26 |
20130345397 | METHODS FOR THE SYNTHESIS OF DICARBA BRIDGES IN PEPTIDES - A method for preparing a peptide or peptides containing a dicarba bridge, comprising: (i) providing a reactable peptide having at least two complementary metathesisable groups or two or more reactable peptides having at least two complementary metathesisable groups between them; (ii) subjecting the reactable peptide or reactable peptides to metathesis to form a reactable peptide or peptides having at least one unsaturated dicarba bridge; and (iii) adding one or more further amino acids to one or both ends of at least one of the reactable peptides. | 2013-12-26 |
20130345398 | Recombinant light chains of botulinum neurotoxins and light chain fusion proteins for use in research and clinical therapy - The present invention relates to the construction, expression, and purification of synthetic or recombinant light chain (LC) | 2013-12-26 |
20130345399 | METHOD OF EXPRESSING PROTEINS WITH DISULFIDE BRIDGES - This invention relates to methods of expressing eukaryotic proteins in prokaryotic hosts, particularly eukaryotic proteins that require formation of disulfide bridges for biological activity. Various approaches are used including fusion to thioredoxin, cytoplasmic expression of disulfide isomerases, deficiencies in thioredoxin and/or glutathione reductases, deficiencies in proteases, and the like. The method is applicable to express monomeric and dimeric forms of the eukaryotic protein with biological activity such as monomeric and dimeric forms of a disintegrin or a disintegrin domain. Included are the vectors, host cells expressing the proteins, the expressed proteins and methods of using the proteins. | 2013-12-26 |
20130345400 | IDENTIFICATION OF A HUMAN GYROVIRUS AND APPLICATIONS - The present invention relates to HGyV, a human gyrovirus related to the chicken anemia virus (CAV). The present invention also relates to a new proteins encoded by HGyV, which proteins display some homology to CAV proteins. Among these new proteins, H-apoptin is of particular interest as it is herein found for the first time in a human virus and can be used for treating cancer. Also provided are methods for detecting the HGyV virus in a subject. | 2013-12-26 |
20130345401 | FIBRINOGEN-PRODUCING TRANSGENIC SILKWORM - Disclosed is a novel means that enables mass production of highly safe fibrinogen at low cost. The transgenic silkworm of the present invention expresses the fibrinogen subunit Aα, Bβ and γ chains in the silk gland cells and produces fibrinogen having coagulation activity in the cocoon filament. Preferably, the transgenic silkworm expresses the subunits in the middle silk gland cells and produces fibrinogen in the sericin layer of the cocoon filament. By recovering fibrinogen from the cocoon of the transgenic silkworm of the present invention, highly safe fibrinogen can be mass-produced at low cost. | 2013-12-26 |
20130345402 | Devices and Methods for Integrated Continuous Manufacturing of Biological Molecules - The present invention relates to a process and apparatus for purifying a molecule of interest from a heterogeneous clarified fluid mixture. The apparatus of the invention generally comprises a continuous perfusion fermentation system, a continuous particle removal system integrated with the perfusion fermentation system; and a continuous purification system integrated with the particle removal system, which is maintained under sterile conditions. The process comprises filtering a heterogeneous clarified fluid mixture by continuous ultrafiltration at a specific flow rate below the transition point of the molecule of interest in the pressure-dependent region of the flux versus TMP curve, wherein the specific flow rate is maintained substantially constant throughout the continuous ultrafiltration. | 2013-12-26 |
20130345403 | AQUEOUS FACTOR VIII SOLUTION - The present invention relates to methods for stabilizing FVIII in aqueous solutions comprising a relatively high concentration of FVIII. The invention furthermore relates to such aqueous solutions as well as use thereof. | 2013-12-26 |
20130345404 | Dual Variable Region Antibody-Like Binding Proteins Having Cross-Over Binding Region Orientation - The invention provides antibody-like binding proteins comprising four polypeptide chains that form four antigen binding sites, wherein each pair of polypeptides forming an antibody-like binding protein possesses dual variable domains having a cross-over orientation. The invention also provides methods for making such antigen-like binding proteins. | 2013-12-26 |
20130345405 | BINDING MOLECULES - The present invention relates to the manufacture of a diverse repertoire of functional heavy chain-only antibodies that undergo affinity maturation, and uses thereof. The invention also relates to the manufacture and use of a diverse repertoire of class-specific heavy chain-only antibodies and to the manufacture and use of multivalent polypeptide complexes with antibody heavy chain functionality, preferably antibody heavy chain binding functionality, constant region effector activity and, optionally, additional effector functions. | 2013-12-26 |
20130345406 | STABLE IGG4 ANTIBODIES - The present invention relates to stabilized IgG4 antibodies, to methods of producing such antibodies and to uses of such antibodies as a medicament. In a main aspect, the invention relates to a stabilized IgG4 antibody, comprising a heavy chain and a light chain, wherein said heavy chain comprises a human IgG4 constant region having a substitution of the Arg residue at position (409), the Phe residue at position (405) or the Lys residue at position (370). | 2013-12-26 |
20130345407 | Activation of Sodium Potassium ATPase - Activation sites on the alpha subunit of sodium potassium ATPase have been discovered. It has also been discovered that certain antibodies that bind to the alpha subunit of sodium potassium ATPase dramatically increase enzyme activity. There has never before been a report of precise activation sites or drug interaction sites for sodium potassium ATPase. Certain methods have also been discovered for treating or preventing diseases associated with low sodium potassium ATPase activity by administering antibodies, antibody fragments and small molecules that bind to the activation sites on the alpha subunit of sodium potassium ATPase. | 2013-12-26 |
20130345408 | ANTIBODY AGAINST AMYLOID PRECURSOR PROTEIN SIGNAL PEPTIDE - An advantage of some aspects of the invention is to provide an antibody against an amyloid precursor protein signal peptide. The invention provides an amyloid precursor protein signal peptide. | 2013-12-26 |
20130345409 | GROWTH FACTOR - VEGF-D, a new member of the PDGF family of growth factors, which among other things stimulates endothelial cell proliferation and angiogenesis and increases vascular permeability, as well as nucleotide sequences encoding it, methods for producing it, antibodies and other antagonists to it, transfected or transformed host cells for expressing it, pharmaceutical compositions containing it, and uses thereof in medical and diagnostic applications. | 2013-12-26 |
20130345410 | NOVEL ANTIBACTERIAL AGENTS - Described herein are novel macrolides, the preparation of novel macrolides, the use of novel macrolides for preventing, treating, or ameliorating various conditions, and the use of novel macrolides as antibacterial agents. | 2013-12-26 |
20130345411 | NOVEL AMINOGLYCOSIDE ANTIBIOTICS - This invention relates to novel aminoglycoside antibiotics, which have potent antimicrobial activity against bacteria, which induce infectious diseases, particularly MRSA, and has no significant nephrotoxicity, and process for producing them. More particularly, the present invention relates to compounds represented by formula (Ia) or their pharmacologically acceptable salts or solvates, or their diastereomer mixtures, antimicrobial agents comprising them, and a process for producing them. | 2013-12-26 |
20130345412 | SYNTHESIS OF THIOETHER CONTAINING TRIALKOXYSILANES - The invention relates to a radical-initiated thiol-ene or thiol-yne “click” reaction that provides a simple and efficient route to diverse trialkoxysilanes. Trialkoxysilanes made in this way are obtained in quantitative to near-quantitative yields with high purity without any or minimal purification. A wide range of functional groups is tolerated in this approach, and even complex alkenes click with the silane precursors. The modular nature of these radical-based thiol-ene or thiol-yne “click” reactions allows a wide variety of pendant groups to be coupled to silane compounds that can then be coupled to a wide variety surfaces in order to modify their material properties. Consequently, such radical initiated thiol-ene and thiol-yne reactions provide facile and efficient methods for preparing an enormous number of surface-active functional trialkoxysilanes. | 2013-12-26 |
20130345413 | MODIFIED CLOSTRIDIAL TOXINS WITH ENHANCED TRANSLOCATION CAPABILITIY - The specification discloses modified Clostridial toxins comprising a Clostridial toxin enzymatic domain, a Clostridial toxin translocation domain, a translocation facilitating domain and an enhanced targeting domain; polynucleotide molecules encoding such modified Clostridial toxins; and method of producing such modified Clostridial toxins. | 2013-12-26 |
20130345414 | TREATING CANCER WITH VIRAL NUCLEIC ACID - This document provides methods and materials related to the use of nucleic acid coding for viruses to reduce the number of viable cancer cells within a mammal. For example, methods for using infectious nucleic acid to treat cancer, engineered viral nucleic acid, methods for making engineered viral nucleic acid, methods for identifying infectious nucleic acid for treating cancer, methods and materials for controlling virus-mediated cell lysis, and methods and materials for assessing the control of virus-mediated cell lysis are provided. | 2013-12-26 |
20130345415 | Methods for biocompatible derivitization of cellulosic surfaces - The present invention describes methods of treating cellulosic materials with a composition that provides increased hydrophobicity to such materials without sacrificing the biodegradability thereof. The methods as disclosed provide for esterification of available hydroxyl groups on cellulosic materials, where such hydroxyl groups are “masked” by bulky organic chains, including that the disclosure provides products made by such methods. The materials thus treated display higher hydrophobicity, barrier function, and mechanical properties, and may be used in any application where such features are desired. | 2013-12-26 |
20130345416 | METHOD FOR PROCESSING NANOFIBRILLAR CELLULOSE AND PRODUCT OBTAINED BY THE METHOD - The invention relates to a method for processing an aqueous gel of nanofibrillar cellulose by removing water from the aqueous gel by means of an organic solvent miscible with water. In the method: aqueous gel is introduced into a volume of organic solvent miscible with water in a controlled manner so that the aqueous gel is kept as a separate phase and forms discrete physical entities containing the nanofibrillar cellulose within the phase; water is changed with the organic solvent in said discrete physical entities of nanofibrillar cellulose; and the physical entities are separated from the volume of organic solvent. | 2013-12-26 |
20130345417 | WATER SOLUBLE ANIONIC BACTERIOCHLOROPHYLL DERIVATIVES AND THEIR USES - The invention provides anionic water-soluble tetracyclic and pentacyclic bacteriochlorophyll derivatives (Bchls) containing at least one, preferably two or three, negatively charged groups and/or acidic groups that are converted to negatively charged groups at the physiological pH, preferably Bchls having a group COO<−>, COS<−>, SO3<−>, PO3<2−>, COOH, COSH, SO3H, and/or PO3H2 bound through an ester or amide bond to one or more of the positions 17<3>, 13<3>, and 3<2> of the tetracyclic or pentacyclic Bchl molecule, for photodynamic therapy and diagnosis. | 2013-12-26 |
20130345418 | PROCESS FOR PURIFICATION OF APREPITANT - The present invention relates to a process for obtaining pure aprepitant substantially free of undesired diastereomeric isomer, namely 5-[2(S)-[1(RS)-[3,5-bis(trifluoromethyl)-phenypethoxy]-3-(S)-(4-fluorophenyl)-morpholin-4-yl-methyl]-3,4-dihydro-2H-1,2,4-triazol-3-one. The present invention further provides an improved process for preparation of aprepitant crystalline form II. The present invention also relates to novel amorphous form of aprepitant, a process for its preparation and to a pharmaceutical composition comprising it. The present invention further relates to aprepitant having a mean particle size of less than about 11.5 microns, a process for its preparation and to a pharmaceutical composition comprising it. Thus, for example, aprepitant having a content of diastereomeric impurity of 1.1% is dissolved in ethyl acetate at 70° C., the solution is concentrated to half the initial volume by distilling off ethyl acetate, and the resulting solid is collected at 0-5° C. to give pure aprepitant substantially free of its diastereomeric impurity. | 2013-12-26 |
20130345419 | AZOLE DERIVATIVE - Provided are novel compounds that bind to FKBP12 or pharmaceutically acceptable salts thereof, as well as new therapeutics useful in the prevention or treatment of alopecia which comprise those compounds or pharmaceutically acceptable salts thereof. Specifically, compounds represented by formula (1) | 2013-12-26 |
20130345420 | SELECTIVE INHIBITORS OF EXCITATORY AMINO ACID TRANSPORTER SUBTYPE 1 (EAAT1/GLAST) - The invention is the discovery of the use of the class of compounds represented by Formula I, as selective inhibitors of excitatory amino acid transporter (EAAT) subtype 1 (EAAT1) and its rodent ortholog L-glutamate/L-aspartate transporter (GLAST) for the study of function and distribution of EAAT1/GLAST in the central nervous system and studies of the physiological and pathological functions of the EAAT1/GLAST subtype in native tissues, cultured neurons, and/or animal models for CNS disorders. | 2013-12-26 |
20130345421 | PROCESS OF ISOLATING ENANTIOMER COMPONENTS FROM ENANTIOMER MIXTURES BY PARTICLE-SIZE-CONTROLLED CRYSTALLIZATION - The present invention discloses a process for isolating enantiomer components from a mixture of enantiomers through particle-size-controlled crystallization, comprising the steps of: (a) forming a solution of a mixture of enantiomers (R) and (S) in a solvent in the absence of any further additives or agents; (b) seeding the solution of step (a) simultaneously or consecutively with seed crystals of enantiomer (R) and with seed crystals of enantiomer (S), wherein the seed crystals of enantiomer (R) differ in size and/or in quantity from the seed crystals of enantiomer (S) to allow separation of the crystals composed of a mixture enriched with enantiomer (R) from the crystals composed of a mixture enriched with enantiomer (S); (c) inducing simultaneous crystallization of enantiomer (R) and enantiomer (S); and (d) isolating crystals composed of a mixture enriched with enantiomer (R) from crystals composed of a mixture enriched with enantiomer (S) through size separation of the crystals, preferably through sieving, melting or sedimentation, in particular through sieving. | 2013-12-26 |
20130345422 | METHOD FOR PRODUCING TRIAZINYL-SUBSTITUTED OXINDOLES - Process for the preparation of triazinyl-substituted oxindoles of formula (3) | 2013-12-26 |
20130345423 | EFFICIENT PEPTIDE COUPLINGS AND THEIR USE IN THE SYNTHESIS AND ISOLATION OF A CYCLOPENTA (G) QUINAZOLINE TRISODIUM SALT - A new method for the synthesis of L-Glutamyl-γ-D-Glutamic acid and its use in the synthesis of (2R)-((4S)-carboxy-4-(4,N-(((6S)-2-(hydroxymethyl)-4-oxo-3,4,7,8-tetrahydro-3H-cyclopenta[g]quinazolin-6-yl)-N-(prop-2-ynyl)amino)benzamido)butanamido)pentanedioic acid, 1 are provided. Also provided is an efficient method for the isolation and purification of the trisodium salt of the abovementioned acid, 2, in a form suitable for long term storage and use in a parenteral dosing form. | 2013-12-26 |
20130345424 | COMPOSITIONS AND USES THEREOF TO AMELIORATE PAIN - Hydrazinopyridazines, fused hydrazinopyridazines, phenylethylhydrazines, or combinations thereof, compositions comprising hydrazinopyridazines, fused hydrazinopyridazines, phenylethylhydrazines, or combinations thereof, and methods for using them for the treatment of pain are described. | 2013-12-26 |
20130345425 | HETEROCYCLICAL CHROMOPHORE ARCHITECTURES - NLO chromophores of the form of Formula I: | 2013-12-26 |
20130345426 | TETRAHYDROCARBOLINE DERIVATIVE - An object of the present invention is to provide a drug having the inhibitory activity on ENPP2 which is a different target from that of the existing drug, as a medicament useful in a urinary excretion disorder patient for whom the existing drug has the insufficient effect. | 2013-12-26 |
20130345427 | COLORANT COMPOUND DERIVED FROM GENIPA AMERICANA GENIPIN AND GLYCINE - The present invention provides colorant compounds and its molecular structural formulas and methods of isolation of the colorant compounds derived from a reaction of | 2013-12-26 |
20130345428 | METHOD FOR PRODUCTION OF PRASUGREL HYDROCHLORIDE HAVING HIGH PURITY - A method for producing prasugrel hydrochloride with a reduced content of 2-acetoxy-5-[5-chloro-1-(2-fluorophenyl)-2-oxopentyl]-4,5,6,7-tetrahydrothieno[3,2-6]pyridine by carrying out the following steps: | 2013-12-26 |
20130345429 | PROCESS AND INTERMEDIATE COMPOUNDS USEFUL IN THE PREPARATION OF STATINS - There is provides a process for the preparation of a compound of formula (7): wherein R is an optionally substituted hydrocarbyl group or an optionally substituted heterocyclic group; provides that R is not a compound of Formula (a): wherein R | 2013-12-26 |
20130345430 | METHOD FOR SYNTHESIZING PIRFENIDONE - A process for synthesizing pirfenidone from bromobenzene having less than about 0.15% by weight dibromobenze is disclosed. Also disclosed are processes of synthesizing pirfenidone without using ethyl acetate or n-butanol, and pirfenidone having controlled levels of ethyl acetate, n-butanol, di(5-methyl-2-pyridinone)benzenes, and other impurities having specified retention times. Also disclosed are formulated dosage forms including the disclosed pirfenidone. | 2013-12-26 |
20130345431 | Alkene Aziridination - Disclosed are metal-bound tetracarbene catalysts, such as iron based aziridination catalyst, having the formula: | 2013-12-26 |
20130345432 | ASYMMETRIC PROCESS FOR MAKING SUBSTITUTED 2-AMINO-THIAZOLONES - The invention provides two process for synthesizing substituted aminothiazolone compounds as inhibitors of 11-β-hydroxy steroid dehydrogenase type 1. The processes allow the stereoselective synthesis of the desired compounds without the use of stoichiometric amounts of chiral catalysts. | 2013-12-26 |
20130345433 | 1,2-BENZISOTHIAZOL-3-ONE COMPOUND PRODUCTION METHOD - The present invention provides a method for producing 1,2-benzisothiazol-3-one compounds by reacting a 2-(alkylthio)benzonitrile compound with a halogenating agent in the presence of water, the method being characterized in that the reaction proceeds while the halogenating agent and water are gradually and simultaneously added to a reaction system containing the 2-(alkylthio)benzonitrile compound. The invention allows the simple and economical production of highly pure 1,2-benzisothiazol-3-one compounds, which are useful as antimicrobial agents, antifungal agents, etc. | 2013-12-26 |
20130345434 | METHOD FOR PRODUCING 1,2-BENZISOTHIAZOL-3-ONE COMPOUND - The present invention provides a method for producing a 1,2-benzisothiazol-3-one compound by reacting a 2-(alkylthio)benzonitrile compound with a halogenating agent in the presence of water, wherein an alkyl halide that is generated as by-product is reacted with a sulfide to form an alkylthiol, which is converted into an alkali metal salt, and then the resulting alkali metal salt is reacted with a 2-halobenzonitrile compound to be converted into a 2-(alkylthio)benzonitrile compound and reused as a starting material for the production of a 1,2-benzisothiazol-3-one compound. By means of the present invention, it is possible to efficiently use the by-product that is generated during the production of a 1,2-benzisothiazol-3-one compound and economically produce a 1,2-benzisothiazol-3-one compound without placing a burden on the environment. | 2013-12-26 |
20130345435 | Preparation method of carfentrazone-ethyl - A preparation method of carfentrazone-ethyl comprises steps of: reacting 1-(5-amino-4-chloro-2-fluorophenyl)-4-difluoromethyl-3-methyl-1H-1,2,4-triazol-5-one with acrylic acid through a diazo arylation reaction to give 2-chloro-3-{2-chloro-5-[4-(difluoromethyl)-4,5-dihydro-3-methyl-5-oxo-1H-1,2,3-triazol-1-yl]-4-fluorophenyl}propionic acid; and reacting the 2-chloro-3-{2-chloro-5-[4-(difluoromethyl)-4,5-dihydro-3-methyl-5-oxo-1H-1,2,3-triazol-1-yl]-4-fluorophenyl}propionic acid with ethanol through an esterification reaction in a presence of an acidic catalyst to give carfentrazone-ethyl. | 2013-12-26 |
20130345436 | method for preparing 2-(N-substituted)-amino-benzimidazole derivatives - A method for preparing 2-(N-substituted)-amino-benzimidazole derivatives is provided, which comprises the following steps: (1) reacting a compound of 2-(N-protecting group)-O-aryl diamine with a compound of N-phenoxycarbonyl monosubstituted amine to obtain a compound of 2-(N-protecting group)-amino aryl urea; (2) in a suitable organic solvent, performing dehydrating cyclization reaction of the compound of 2-(N-protecting group)-amino aryl urea in the presence of an organic base and dichloro triphenylphosphine prepared by triphenylphosphine oxide with oxalyl chloride or diphosgene or triphosgene, or dibromo triphenylphosphine prepared by triphenylphosphine oxide with bromine, to produce a compound of 1-protecting group-2-(N-substituted)-amino-benzimidazole; (3) deprotecting the resulting compound of 1-protecting group-2-(N-substituted)-amino-benzimidazole to obtain the compound 2-(N-substituted)-amino-benzimidazole. | 2013-12-26 |
20130345437 | PROCESS FOR PREPARING BIPHENYL IMIDAZOLE COMPOUNDS - The invention provides processes for preparing intermediates useful for preparing compounds of the formula: | 2013-12-26 |
20130345438 | 3-SUBSTITUTED-3-HYDROXY OXINDOLE DERIVATIVES AND PROCESS FOR PREPARATION THEREOF - The present invention relates to expedient method for synthesis of 3-substituted-3-hydroxy-oxindole derivatives, which are useful as synthetic precursors to valuable pharmaceutical compounds. These are synthesized by reacting nitromethane with the corresponding isatins of formula (I). The reaction process of isatins was carried using water as a solvent at room temperature to form the corresponding 3-hydroxy-3-nitromethylindolin-2-ones of formula (II). | 2013-12-26 |
20130345439 | Novel 1-Aryl-3-Azabicyclo[3.1.0]Hexanes: Preparation And Use To Treat Neuropsychiatric Disorders - The invention provides novel, multiply-substituted 1-aryl-3-azabicyclo[3.1.0]hexanes, and related processes and intermediates for preparing these compounds, as well as compositions and methods employing these compounds for the treatment and/or prevention of central nervous system (CNS) disorders, including depression and anxiety. | 2013-12-26 |
20130345440 | CARBOXYLATION OF POLY-/OLIGOTHIOPHENES - The present invention relates to a process for carboxylation of poly/oligothiophenes using CO | 2013-12-26 |
20130345441 | METHOD FOR PREPARING ALCOHOL CARBONATE USING RARE EARTH OXIDES AS CATALYSTS - Disclosed is a method for preparing, by transcarbonation, a compound of formula (I), including reacting a polyol of formula (II) with an alkyl carbonate or an alkylene carbonate in the presence of a catalytic system consisting of a catalytic entity selected from among the rare earth oxides or the mixtures thereof, and optionally an inert substrate. | 2013-12-26 |
20130345442 | INSECTICIDAL FERMENTATION BROTH FROM ACTINOMYCETES CONTAINING ENHANCED RATIO OF ACTIVE TO INACTIVE DUNAIMYCINS - Methods and compositions are provided for the preparation of insecticidal compositions. | 2013-12-26 |
20130345443 | FLUOROSULFONYL GROUP-CONTAINING MONOMER AND ITS POLYMER, AND SULFONIC ACID GROUP-CONTAINING POLYMER - A fluorosulfonyl group-containing monomer having a high polymerization reactivity and plural fluorosulfonyl groups, a fluorosulfonyl group-containing polymer and a sulfonic acid group-containing polymer, obtained by using the monomer. | 2013-12-26 |
20130345444 | PRODUCTION METHOD OF OPTICALLY ACTIVE DIHYDROBENZOFURAN DERIVATIVE - Provided is a production method of an optically active dihydrobenzofuran derivative. A production method of an optically active form of a compound represented by the formula: wherein each symbol is as defined in the specification, or a salt thereof and the like. | 2013-12-26 |