52nd week of 2008 patent applcation highlights part 51 |
Patent application number | Title | Published |
20080318793 | Method For Producing a Superconductive Element - The invention relates to a method for producing a superconductive element to be used as a wire-in-channel superconductor in magnetic resonance imaging (MRI) and in nuclear magnetic resonance (NMR) applications, which superconductive element contains a superconductive wire and a copper component having a longitudinal groove and the superconductive wire being positioned in the groove. In order to produce the wire-in-channel superconductive element by a mechanical contact between the superconductive wire and a wall of the groove in the copper component, at least one contact surface is coated with a lead free solder material before having the mechanical contact. In order to enhance the thermal and electrical conduction and to create a bond between the said components the soldering material is fused in annealing process step. | 2008-12-25 |
20080318794 | Superconductive wire and method for producing the same - A superconductive wire wherein the superconductive wire has a core portion containing magnesium diboride as the main component and a continuous metallic sheath firmly adhered to the core portion; the core portion is kept substantially vacuum; and the content of an inert gas such as an Ar gas contained in the core portion is in the range of 0.00002 to 10 ppm. Further, disclosed is a method for producing a superconductive wire, wherein the method comprises the steps of mixing powder of a source material constituting magnesium diboride to form a core portion of the superconductive wire in an inert gas, filling a pipe with the mixed material powder in vacuum environment, sealing the pipe with vacuum after filled with the material powder, forming magnesium diboride powder by heating the vacuum-sealed pipe (sheath), and forming the core portion by wiredrawing the pipe in the state where the magnesium diboride powder is sealed with vacuum, and the core portion firmly sticks to the wiredrawn metallic pipe. The core portion is kept vacuum, and the content of an inert gas contained in the core portion is in the range of 0.00002 to 10 ppm. | 2008-12-25 |
20080318795 | Methods for making character strings, polynucleotides and polypeptides having desired characteristics - In silico nucleic acid recombination methods, related integrated systems utilizing genetic operators and libraries made by in silico shuffling methods are provided. | 2008-12-25 |
20080318796 | EFFICIENT ARRAYS OF AMPLIFIED POLYNUCLEOTIDES - The present invention is related generally to analysis of polynucleotides, particularly polynucleotides derived from genomic DNA. The invention provides methods, compositions and systems for such analysis. Encompassed by the invention are arrays of polynucleotides in which the polynucleotides have undergone multiple rounds of amplification in order to increase the strength of signals associated with single polynucleotide molecules. | 2008-12-25 |
20080318797 | PROCESS FOR SCREENING OF A BINDING PEPTIDE SPECIFIC FOR SPECIFIC RNA AND RNA BINDING PEPTIDES THEREFROM - The present invention relates to a screening method for RNA specific binding peptide using alpha-helical peptides. The screening method for RNA specific binding peptide of the present invention using alpha-helical peptides enables the selection of a peptide having strong binding capacity to a specific RNA having particular morphology and nucleotide sequence and the investigation of functions of RNA using the selected peptides, and is very useful for the production of a new drug using synthetic peptide having more powerful and specific binding capacity to RNA than those of natural peptides. | 2008-12-25 |
20080318798 | Antigen Detection - The present invention relates to methods of detecting specific cell surface antigens present in a sample of cells being tested and in particular blood group antigens, which methods do not employ the addition of extrinsic labels to detect said cell surface antigens. Typically detection is carried out using an intrinsic fluorescence capability of the cells being tested. | 2008-12-25 |
20080318799 | Method of Quantifying the G Protein-Coupled Receptor (Gpcr)/G Protein Coupling Using a Cell Membrane Array - The invention relates to a method for quantifying G protein-coupled receptor (GPCR)-G protein binding by means of using a cell membrane array, which comprises (i) putting an unlabeled candidate compound in contact with a cell membrane array in the presence of labeled GTP or of a labeled, non-hydrolyzable analog thereof, in conditions allowing the interaction between said compound and said GPCR present in said cell membranes, and between said labeled GTP or analog thereof and said G protein present in said membranes; (ii) washing; and (iii) quantifying the signal obtained due to the binding of the labeled GTP (or analog) to said G protein. It is applicable in the analysis of the interaction between compounds and cell membrane receptor proteins and of the intracellular signaling mechanisms triggering this interaction mechanism mediated by said compounds. | 2008-12-25 |
20080318800 | METHODS AND COMPOSITIONS FOR DETECTING AUTOIMMUNE DISORDERS - The invention provides methods and compositions useful for detecting autoimmune disorders. | 2008-12-25 |
20080318801 | METHOD AND KIT FOR EVALUATING RNA QUALITY - The present invention relates to a method for analyzing and rapidly determining the quality of a test RNA of unknown quality utilizing a novel quantitative reverse transcription-polymerase chain reaction (RT-PCR) based method. The present invention is based on normalizing the 3′ end of the house-keeping gene glyceraldehyde-3-phosphate dehydrogenase (GAPDH) to the relative abundance of the 5′ end of GAPDH MRNA in the test RNA. The present invention is particularly useful in pre-screening postmortem tissue samples for microarray experiments and for evaluating large quantities of samples which would be time consuming and expensive to analyze by methods currently in use. | 2008-12-25 |
20080318802 | METHODS AND COMPOSITIONS FOR TAGGING AND IDENTIFYING POLYNUCLEOTIDES - The invention provides methods and compositions for attaching oligonucleotide tags to polynucleotides for the purpose of carrying out analytical assays in parallel and for decoding the oligonucleotide tags of polynucleotides selected in such assays. Words, or subunits, of oligonucleotide tags index submixtues in successively more complex sets of submixtures (referred to herein as “tiers” of submixtures) that a polynucleotide goes through while successive words are added to a growing tag. By identifying each word of an oligonucleotide tag, a series of submixtures is identified including the first submixture that contains only a single polynucleotide, thereby providing the identity of the selected polynucleotide. The analysis of the words of an oligonucleotide tag can be carried out in parallel, e.g. by specific hybridization of the oligonucleotide tag to its tag complement on an addressable array; or such analysis can be carried out serially by successive specific hybridizations of labeled word complements, or the like. | 2008-12-25 |
20080318803 | Biomarkers for Monitoring Impdh Pathway Inhibition - The present invention is directed to methods for ameliorating reproductive disorders. More specifically, the present invention describes methods and compositions for using IL-17 in the treatment of various infertility-related defects. | 2008-12-25 |
20080318804 | Es Cell Mutation Method and System - This is intended to provide a technique for providing a stem cell having a mutation in both alleles (a pair of alleles). A method for producing a stem cell having a mutation in both chains of alleles which comprises: A) the step of providing a stem cell; B) the step of preventing Blm alleles from functioning in the stem cell; and C) the step of inducing mutation in the stem cell. It is also intended to provide a library of stem cells having a mutation in both chains of alleles wherein stem cells involved in the library have the mutation transferred thereinto over the entire genome. | 2008-12-25 |
20080318805 | Method and apparatus for producing high-yield tissue microarray blocks - A method and apparatus are provided for forming high-yield tissue microarray blocks capable of producing 1,000 or more replicate slides. In one embodiment, a plurality of donor tissue samples are minced and suspended in separate molten liquid carriers to form a plurality of separate two-phase mixtures of solid minced tissue and molten wax. Each of the two-phase mixtures is preferably formed into elongated columns and transferred into a separate well of a microarray block. A method and apparatus are provided for forming the elongated molten wax columns with minced tissue evenly distributed along the length of each column. The apparatus for forming the array includes an extrusion mechanism for transferring the columns of two-phase mixtures into the deep wells of the microarray block. The two-phase mixture may alternately be cooled and allowed to solidify before being transferred into the microarray block. An alternate embodiment is provided wherein cell cultures are utilized as starting material as opposed to solid donor tissue samples. | 2008-12-25 |
20080318806 | DEVICE FOR CHEMICAL AND BIOCHEMICAL REACTIONS USING PHOTO-GENERATED REAGENTS - This invention provides method and apparatus for performing chemical and biochemical reactions in solution using in situ generated photo-products as reagent or co-reagent. In particular, the present invention provides methods and devices for generating a photogenerated reaction in solution on a substrate comprising generating a light beam using an optical device system comprising a light source and a computer-controlled spatial optical modulator comprising a digital micromirror device and using the spatial optical modulator to direct light to fluidly isolated reaction sites under conditions such that a photogenerated reaction takes place. The method and apparatus of the present invention have applications in parallel synthesis of molecular sequence arrays on solid surfaces. | 2008-12-25 |
20080318807 | Iterated Branching Reaction Pathways Via Nucleic Acid-Mediated Chemistry - The present invention provides methods and compositions for performing multi-step nucleic acid mediated synthesis of a highly diverse collection of molecules, for example, small molecules and polymers. In the method, in at least two steps, multiple reaction intermediates and/or products are produced in the same step by different chemical reactions. | 2008-12-25 |
20080318808 | MASSIVELY PARALLEL SYNTHESIS OF BIOPOLYMERIC ARRAYS - Methods for fabricating dense arrays of polymeric molecules in a highly multiplexed manner are provided using semiconductor-processing-derived lithographic methods. Advantageously, the methods are adaptable to the synthesis of a variety of polymeric compounds. For example, arrays of branched peptides and polymers joined by peptide bonds may be fabricated in a highly multiplexed manner. | 2008-12-25 |
20080318809 | CORRECTION FOR ILLUMINATION NON-UNIFORMITY DURING THE SYNTHESIS OF ARRAYS OF OLIGOMERS - The present invention provides an apparatus and a method for the synthesis of arrays of oligomers that have tight illumination intensity requirement. The apparatus and the method contain a mechanism to correct for illumination non-uniformity during the oligomer array synthesis process. To correct for illumination non-uniformity, the illumination intensity of different oligomer synthesis positions across an area in which oligomers are synthesized are determined first. Then, the differences in illumination intensity among the positions are evaluated mathematically. Next, any non-uniformity in illumination intensity is corrected by either reducing the intensity of the light for the brighter positions before the light reaches the illumination area or reducing the illumination time of the brighter positions during one protection group deprotection period. | 2008-12-25 |
20080318810 | Self-Breakable Yield Point Enhancer for Oil Based Drilling Mud - The present invention relates to a liquid, self-breakable, temporary viscosifier agent (yield point enhancer) for oil based drilling muds, obtained by reacting one or more dicarboxylic fatty acids with a secondary dialkanolamine and thereafter with a tertiary tialkanolamine, and to oil based drilling muds containing it. | 2008-12-25 |
20080318811 | Versatile Additives For Well Cementing Applications - The present invention provides a versatile additive for improving the properties of a cement slurry made with portland cement and to be utilized in well cementing, said versatile additive comprising type of silicates and/or borates that inhibit gelation occurring with the interstitial phase. The additive of the present invention improves significantly the rheology (i.e., strong dispersing effect) and can even overcome severe gelation problems. At temperature above about 88° C. (190° F.) the additive acts as retarder aid, enabling to reduce considerably the concentration of retarder required to achieve a given thickening time. | 2008-12-25 |
20080318812 | OIL BASED CONCENTRATED SLURRIES AND METHODS FOR MAKING AND USING SAME - New hydrocarbon based slurry compositions and drilling, fracturing, completion and production fluids including the hydrocarbon based slurry composition are disclosed, where the composition includes a hydrocarbon soluble polymer adapted to decrease particle settling rates of particulate materials present in the fluids and in the case of fluids that include hydratable materials to increase hydration properties of such materials. | 2008-12-25 |
20080318813 | Dispersant reaction product with antioxidant capability - A novel crankcase dispersant reaction product having fused therein an antioxidant moiety whereby the dispersant reaction product can function as an antioxidant while retaining at least two structural domains, one being a polar domain for association with sludge and a hydrocarbyl domain for oil solubility, so that the dispersant can function as a chemical agent to suspend sludge and prevent agglomeration of sludge precursors and soot so the latter can be readily removed from the system, such as by filtering, instead of being deleteriously deposited on internal engine components, as well as lubricant compositions incorporating such novel dispersant and, for instance, engines lubricated with such lubricant compositions. | 2008-12-25 |
20080318814 | Lubricant Oil and Lubricating Oil Additive Concentrate Compositions - A lubricant oil composition having a synergistic oxidative stability is disclosed, the composition comprising at least one hindered phenolic antioxidant, at least one mono-boronated hindered phenolic antioxidant, at least one di-boronated hindered phenolic antioxidant, and at least one alkylated diphenylamine. The invention also provides a lubricating oil additive concentrate composition that imparts synergistic oxidative stability to a lubricant oil upon its addition, the concentrate composition comprising at least one hindered phenolic antioxidant, at least one mono-boronated hindered phenolic antioxidant, at least one di-boronated hindered phenolic antioxidant, and at least one alkylated diphenylamine. Further, the concentrate compositions of the present invention may also be prepared with a high concentration of hindered phenolic antioxidants without deleterious effects on viscosity or lubricant solubility. | 2008-12-25 |
20080318815 | SYNERGISTIC LUBRICATING OIL COMPOSITION CONTAINING A MIXTURE OF A NITRO-SUBSTITUTED DIARYLAMINE AND A DAIRYLAMINE - Disclosed is a lubricating oil composition containing an oil of lubricating viscosity and a particularly effective mixture of a nitro-substituted diphenylamine and a diarylamine which together provide superior oxidation inhibition. | 2008-12-25 |
20080318816 | Method of Increasing Hydrolytic Stability of Magnesium Overbased Products - The hydrolytic stability of magnesium overbased products is significantly improved by the addition or inclusion of a mixture or reaction product of an alkylphenol resin with a mixture of an alkenyl succinic anhydride and the acid thereof, and an alkyl amine. These magnesium overbased products are useful additives to fuel oils to improve their corrosion-causing tendencies. In one non-limiting embodiment, the alkylphenol resin is nonylphenol resin and the succinic anhydride is a partially hydrolyzed succinic anhydride having from 14 to 26 carbon atoms, along with the acid thereof. The mixtures and reaction products also serve as asphaltene inhibitors in the fuel oils. | 2008-12-25 |
20080318817 | Lubricant Composition - The lubricating oil composition of the present invention comprises a base oil for lubricating oil, (A) at least one species selected from the phosphorus compounds represented by the following General Formula (1) or (2) as well as metal salts (excluding molybdenum salts) and amine salts thereof, and (B) an organic molybdenum compound not containing sulfur as a constituent element (in the formula, R | 2008-12-25 |
20080318818 | Lubricating Compositions - A method of lubricating a marine diesel 2-stroke engine comprising: (1) monitoring performance characteristics of said engine; (2) selecting a lubricating composition to modify the performance characteristics of the engine, wherein the lubricating composition is prepared by in-situ controlled blending of at least two different fluids, said fluids comprising: (i) a first fluid comprising an additive package with one or more overbased detergents, and optionally other performance additives; (ii) a second fluid comprising an additive package with one or more neutral detergents or overbased detergents, and optionally other performance additives, with the proviso that the first fluid has a ratio of Σ(wt % of overbased detergents)/Σ(wt % of all additives in the fluid) greater than the second fluid; and (iii) a third fluid comprising an oil of lubricating viscosity; and (3) supplying the lubricating composition of step (2) to the engine, with the proviso that the lubricating composition comprises at least one of the first fluid or the second fluid. | 2008-12-25 |
20080318819 | GREASE COMPOSITION AND BEARING - A grease composition which is suitable for a ball bearing exposed to high temperatures and exhibits stable lubricity for a prolonged period of time, and a bearing which encapsulates the grease composition are provided. | 2008-12-25 |
20080318820 | Oil Composition for Use in Trace Oil Supply Cutting/Grinding Work - This invention provides an oil composition for cutting and grinding by minimum quantity lubrication system, characterized by comprising an ester oil with a kinematic viscosity of 0.5-20 mm | 2008-12-25 |
20080318821 | Dust-reduced Micronized wax mixtures comprising Polyethylene Glycol (PEG) compounds - Wax mixture with reduced dust formation, comprising two or more components A, B, C and/or D, component A acting as an auxiliary and comprising one or more polyethylene glycols or polyethylene glycol derivatives, and component B standing for one or more amide waxes, component C for one or more hydrocarbon waxes, and component D for one or more oxidized long-chain hydrocarbon waxes. | 2008-12-25 |
20080318822 | NATURAL CLEANING COMPOSITIONS - A cleaning composition with a limited number of natural ingredients contains alkyl polyglucoside, ethanol and colloidal silica. The cleaning composition optionally has a small amount of glycerol. The cleaning composition optionally has a small amount of fragrance. The cleaning composition can be used to clean hard surfaces and cleans as well or better than commercial compositions containing synthetically derived cleaning agents. | 2008-12-25 |
20080318823 | Water-Soluble Detergent Composition for Cleaning Liquid Crystal and Preparation Method Thereof - A water soluble detergent composition for liquid crystal is presented. The composition includes 10-50 wt % of polyethylene glycol biester, 5-60 wt % of fatty alcohol polyoxyethylene ether, 5-20 wt % of alkyl tri-polyoxyethylene ether sulfate tri-fatty alcohol amine and/or alkenyl tri-polyoxyethylene ether sulfate tri-fatty alcohol amine, 1-15 wt % of alkyl benzene sulfonic acid, 1-10 wt % of lecithin, and 5-50 wt % of water. The detergent composition can effectively remove liquid crystal material invading into the gap of the liquid crystal panel, and foreign substances attached on the substrate surface. | 2008-12-25 |
20080318824 | Hairdressing Preparation Cleansers and Usage Method Thereof - It is an object of the invention to provide a hair cleanser that has a high cleansing effect on hairdressing preparation and can provide smoothness to the hair. | 2008-12-25 |
20080318825 | Hair Treatment Agent - The subject matter of the present invention is a hair treatment agent that can be used for example as a hair cleaning agent or as a hair rinse, and is preferably present in the form of an optically clear product. The hair treatment agent according to the present invention contains hydrophilic silicones and hydrophobic silicones. | 2008-12-25 |
20080318826 | METHODS AND AGENTS FOR CLEANING AND DISINFECTING FRAGILE MEDICAL APPLIANCES - The invention relates to the use of agents, which contain at least one disinfection system based on selected organic peracids and combinations of peracids, in automatically functioning systems, in which fragile medical appliances, in particular, endoscopes, are cleaned and disinfected. According to the invention, the appliances are brought into contact with an aqueous disinfection agent solution after they have been treated and/or at the same time they are being treated with an aqueous cleaning solution. The invention also relates to cleaning and disinfection agents and methods which are all suited for carrying out this purpose. | 2008-12-25 |
20080318827 | Waterless carwash liquid composition and method for producing the same. - The present invention is a substantially nonabrasive, liquid car cleaner composition which cleans car surfaces without an external source of water to wash or rinse. The liquid cleaner is a composition of up to toxaphene 15%, sodium lauryl sulfate 10%, paraffin 10%, isopropyl alcohol 15%, and water 50%. | 2008-12-25 |
20080318828 | Incorporation of Antioxidant in Detergent Composition - A process for incorporation of up to 2% antioxidant into a granular detergent formulation comprising at least 5% organic surfactant, including the steps of: a) dissolving the antioxidant in an organic surfactant selected from the group comprising anionic surfactant, nonionic surfactant and mixtures thereof, provided that the organic surfactant contains less than 5% by weight, preferably less than 3% by weight soap and most preferably is soap free; and b) adding the solution formed in step a) to the detergent formulation and use of the granular laundry detergent composition to confer improved deposition of the antioxidant onto rubber during a wash process. | 2008-12-25 |
20080318829 | Processes For Production and Purification of Normal Propyl Bromide - A process for oxygen-initiated hydrobromination of propene to form a crude reaction mixture of 95 GC area % n-propyl bromide. The process includes feeding an oxygen-containing gas, propene and hydrogen bromide into a liquid phase mixture comprised of n-propyl bromide and hydrogen bromide. At least the oxygen-containing gas and the propene of the feed are fed subsurface to the liquid phase mixture and either (a) the oxygen-containing gas and the propene do not come together in the absence of hydrogen bromide or (b) the oxygen-containing gas and the propene come together only in a propene:oxygen molar ratio in the range of 145:1 to 180:1. Purification processes provide a propyl bromide product containing at least 99.7 GC area % n-propyl bromide. Also provided is a novel composition of enhanced thermal stability which comprises a mixture of n-propyl bromide and isopropyl bromide. The mixture has an n-propyl bromide content of at least 99.7 GC area %, and an isopropyl bromide content of no more than 0.05 GC area %. The mixture, if subjected to storage in a closed chemically inert container at 60° C. for at least 480 hours, has an APHA color of 10 or less while the mixture is devoid of any added stabilizer component. | 2008-12-25 |
20080318830 | Liquid Detergent Comprising a Dye Fixing Agent - Liquid washing and cleaning compositions are claimed, which comprise, as a surfactant, one or more of the components of linear alkylbenzenesulfonate, olefinsulfonate, alkylsulfate as well as soap and a nonionic surfactant, and, as a dye fixative, homo- and copolymers of diallyldimethylammonium chloride or the reaction products of cyanamides with aldehydes and ammonium salts or cyanamides with aldehydes and monoamines or monoamines and/or polyamines with epichlorohydrin or polyamines with cyanamides and amidosulfuric acid. | 2008-12-25 |
20080318831 | Natural Cleaning Composition - A cleaning composition with a limited number of natural ingredients contains alkyl polyglucoside and ethanol. The cleaning composition optionally contains glycerol. The cleaning composition optionally contains essential oil. The cleaning composition optionally has a small amount of buffer, such as a natural inorganic buffer. The cleaning composition can be used to clean hard surfaces and cleans as well or better than commercial compositions containing synthetically derived cleaning agents. | 2008-12-25 |
20080318832 | Liquid detergent compositions with low polydispersity polyacrylic acid based polymers - Liquid detergent compositions comprising a polymer comprising polyacrylic acid monomers having a low number average molecular weight, ranging from about 1000 to about 10,000 amu, and a very low polydispersity, less than about 5, wherein the liquid detergent comprises less than about 50% of any non-aminofunctional solvent. The invention is also directed to liquid detergents compositions comprising beneficial mixtures of the low molecular weight, very low polydispersity polyacrylic acid based polymers with specific polymers. | 2008-12-25 |
20080318833 | Stabilizing Composition - The present invention relates to compositions of UV absorbers and optionally additional antioxidants. The compositions are useful for the protection and stabilization of photosensitive ingredients such as colorants, dyes, scents, fragrances and active ingredients in body care products, household products or inks against the deleterious effects of ultraviolet radiation and oxygen. | 2008-12-25 |
20080318834 | Antimicrobial Lactoferrin Compositions for Surfaces, Cavities, and Foodstuff - The present invention relates to a method and composition for decontaminating surfaces, in particular surfaces in the oral cavity or wounded skin, inert surfaces such as from surgical instruments, or food stuffs, such as meat, wherein the method consists of treating the surface with a solution of lactoferrin of acid pH; a solution of lactoferrin and EDTA; a solution of lactoferrin and EDTA of acid pH, or combinations thereof. The solutions may optionally further comprise a polysaccharide, preferably a polysaccharide negatively charged at about neutral pH, such pectin. | 2008-12-25 |
20080318835 | Novel Integrin Ligand ITGL-TSP - ITGL-TSP polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing ITGL-TSP polypeptides and polynucleotides in the design of protocols for the treatment of, angiogenic diseases (cancer, cancer metastasis, chronic inflammatory disorders, rheumatoid arthritis, atherosclerosis, macular degeneration, diabetic retmopathy), restenosis, Alzheimer's, disease and tissue remodeling, among others, and diagnostic assays for such conditions. | 2008-12-25 |
20080318836 | sCD Fingerprints - The present invention relates to the use of cluster of differentiation (CD) molecules in detecting the presence and progression of one or more disease states in an individual. In particular it relates to the use of profiles of shed CD (sCD) molecules in detecting an assessing the progress of one or more disease states in an individual. Further uses of sCD profiles according to the present invention are also described. | 2008-12-25 |
20080318837 | Pharmaceutical Formation For Increased Epithelial Permeability of Glucose-Regulating Peptide - What is described is a pharmaceutical formulation comprising a mixture of a pharmaceutically effective amount of glucose-regulating peptide (GRP) and enhancers, wherein the pharmaceutical formulation is used in the treatment of a metabolic syndrome. | 2008-12-25 |
20080318838 | PEPTIDES - PTH compounds having PTH-like activity and comprising at least one modification, said modification being either
| 2008-12-25 |
20080318839 | Ligand activated transcriptional regulator proteins - Fusion proteins for use as ligand-dependent transcriptional regulators are provided. The fusion proteins include a nucleotide binding domain operatively linked to a ligand-binding domain. They also can include a transcription regulating domain. The nucleotide binding domain is a zinc-finger peptide that binds to a targeted contiguous nucleotide sequence of from 3 to about 18 nucleotides are provided. The fusion proteins are used for gene therapy. Also provided are polynucleotides encoding the fusion proteins, expression vectors, and transfected cells. | 2008-12-25 |
20080318840 | Compositions of Alpha-Fetoprotein and Inducers of Apoptosis for the Treatment of Cancer - The invention relates to novel compositions comprising alpha-fetoprotein (AFP) and methods for preventing, treating or inhibiting a malignant neoplasm expressing an alpha-fetoprotein receptor (AFPR) with or without multidrug resistance. Compositions comprising a non-covalent complex of an exogenous AFP, and at least one apoptosis-inducing agent selected from the group comprising mitochondrial membrane permeabilizing agents, mitochondrial pore opening inducing agents, ionophores, caspase 9 activators, caspase 3 activators and retinoids, are provided, wherein the at least one apoptosis-inducing agent reversibly binds to the exogenous AFP. The invention also provides for a process for butanol extraction of porcine alpha-fetoprotein obtained from blood and amniotic fluid extracted during early embryogenesis. | 2008-12-25 |
20080318841 | Method For Preparing a Factor H Concentrate and the Use Thereof in the Form of a Drug - The invention relates to the use of a factor H for producing a drug for treating Uremic Haemolytic Syndrome (UHS), to a method for purifying the factor H from a frozen fresh plasma and to a factor H concentrate obtainable by said method. | 2008-12-25 |
20080318842 | Cyclic Isodityrosine Derivatives - [Problems] To provide a novel cyclic isodityrosine derivative having a physiological effect.
| 2008-12-25 |
20080318843 | Device and Method for the Delivery of Drugs for the Treatment of Posterior Segment Disease - Hydrogel lenses are infused with a drug for the treatment of posterior segment disease. The lenses are placed in contact with the subject's cornea. Drugs can be passively released from the hydrogel and can migrate around the globe of the eye to the posterior segment. | 2008-12-25 |
20080318844 | COMPOSITION AND METHOD FOR THE TREATMENT OF DISEASES AFFECTED BY HISTONE DEACETYLASE INHIBITORS - The present invention includes methods of treatment and compositions for treating diseases related to the activity of a histone deacetylase in a subject by administering to the subject an effective amount of a modified FK228 compound comprising an amino acid conjugate which constitutes an amino thiol, a hydroxy thiol, a dithiol, or a hydroxamic acid, instead of a hydroxy-mercapto-heptenoic acid moiety in FK228. | 2008-12-25 |
20080318845 | Selective Vpac2 Receptor Peptide Agonists - The present invention relates to peptides that selectively activate the VPAC2 receptor and are useful in the treatment of diabetes. | 2008-12-25 |
20080318846 | SENSITIZATION OF TUMOR CELLS TO RADIATION THERAPY THROUGH THE ADMINISTRATION OF ENDOTHELIN AGONISTS - Methods to sensitize tumor cells to radiation therapy through the administration of an endothelin agonist such as the ET | 2008-12-25 |
20080318847 | Use of Antagonist of Oxytocin and/or Vasopressin in Assisted Reproduction - The present invention relates to the use of antagonists of oxytocin, antagonists of oxytocin and vasopressin, or antagonists of vasopressin, or their pharmaceutically accepted salts, or their combinations with other drugs for the manufacture of a medicament which main profile of action is inhibition of oxytocin and/or vasopressin receptors in non-pregnant uterus of mammals, that results in improvement of uterine receptivity in embryo transfer. It further relates to the application of these substances for the manufacture of a medicament for regulating the uterine contractile activity in cases of artificial insemination. | 2008-12-25 |
20080318848 | Kahalalide Compositions - The present invention is directed to new kahalalide antitumoral compounds, in particular to analogs of kahalalide F, useful as antitumoral, antiviral, and antifungal agents. | 2008-12-25 |
20080318849 | Kahalalide F and Related Compounds - A process is provided for preparing kahalalide F and which leads to other kahalalide mimic compounds having useful biological activity. | 2008-12-25 |
20080318850 | Glycopegylated Factor Ix - The present invention provides conjugates between Factor IX and PEG moieties. The conjugates are linked via an intact glycosyl linking group interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from glycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto a glycosyl residue on the peptide. Also provided are methods for preparing the conjugates, methods for treating various disease conditions with the conjugates, and pharmaceutical formulations including the conjugates. | 2008-12-25 |
20080318851 | Acid-labile subunit (ALS) of insulin-like growth factor binding protein complex - The acid-labile sub-unit (ALS) of insulin like growth factor binding protein complex in biologically pure form is described. | 2008-12-25 |
20080318852 | Epitopes Related to Coeliac Disease - The invention herein disclosed is related to epitopes useful in methods of diagnosing, treating, and preventing coeliac disease. Therapeutic compositions which comprise at least one epitope are provided. | 2008-12-25 |
20080318853 | Diagnostic and Therapeutic Use of a Novel Growth Factor, Neublasmin - The present invention relates to the field of diagnostic and therapeutic use of proteins and genes, in particular to the diagnostic and therapeutic use of a secreted human hormone/growth factor, Neublasmin, and use or the gene coding for Neublasmin in the diagnosis and treatment of testicular disorders, in particular diagnosis and treatment of germ cell tumours and infertility. The invention also relates to use of Neublasmin in the treatment of CNS disorders. Neublasmin is expressed at high levels in human adult testicles and in developing mouse testicles from pn 22 and onwards. Expression or Neublasmin is strongly up-regulated in carcinoma in situ. Expression is also seen in foetal and adult brain. | 2008-12-25 |
20080318854 | Method for regulating neurite growth - This invention relates to a method of inhibiting neuronal cell death, including protecting neronal cells from cell death and the effects of stress, such as high or low pH, comprising administering to the cells an effective amount of Teneurin C-terminal Associated Peptide (TCAP). The invention provides the use of TCAP to prevent and/or treat a number of brain conditions, such as hypoxiaischemia and brain alkalosis or various brain or spinal cord injuries due to physical or physiological stresse. In one aspect the invention provides a use of TCAP to increase β-tubulin, β-actin levels in neuronal cells and/or to increase fasciculation among neuronal cells, in culture or in tissue. In another aspect, the invention provides a method of treating various pH induced neuronal conditions. | 2008-12-25 |
20080318855 | DNA ENCODING FOR RECOMBINANT POLYPEPTIDE EMUTANTS OF HUMAN STROMAL CELL-DERIVED FACTOR 1 - This invention is generally directed to a recombinant method of producing SDF-1 receptor antagonists. More particularly, the invention is directed to the isolated and/or recombinant polynucleotide sequences encoding analogs of human SDF-1 alpha or beta and, in particular, SDF-1 analogs having the proline at residue position number 2 replaced with a glycine to provide an SDF-1 receptor antagonist. The recombinant method can be used to produce drugs for a variety of therapeutic uses including, but not limited to, treatment of cancer, inhibiting angiogenesis, and hematopoietic cell proliferation. | 2008-12-25 |
20080318856 | MONOMER PROTEIN WITH BONE MORPHOGENETIC ACTIVITY AND MEDICINAL AGENT CONTAINING THE SAME FOR PREVENTING AND TREATING DISEASES OF CARTILAGE AND BONE - This invention provides for a protein of the TGF-β superfamily in which the cysteine involved in the normal formation of homodimers is changed to another amino acid. These mutant proteins, as monomers, display higher bone morphogenetic activity than the wild-type protein dimers. Also provided is a method for producing and isolating these monomers by plasmid driven expression in various host systems including | 2008-12-25 |
20080318857 | Compositions and Methods for the Intracellular Disruption of Vegf and Vegfr-2 By Intraceptors - The present invention provides an intraceptor that interacts with and decreases activity of with VEGF and/or a VEGFR for the treatment of angiogenesis-related conditions. The present invention further provides pharmaceutical compositions, and methods of use thereof, for the treatment and prevention of an angiogenesis-related condition using said intraceptors. The invention further provides for nucleic acids encoding said intraceptors. | 2008-12-25 |
20080318858 | Isolated Recombinant Vaccinia Virus Complement Control Protein (Hrvcp) Polypeptide - An isolated recombinant vaccinia virus complement control protein (hrVCP) polypeptide comprises a modified amino acid sequence comprising one or more amino acid substitutions to an amino acid sequence as set forth in SEQ ID NO: 2. The hrVCP polypeptide exhibits a complement activation regulatory activity greater than a complement activation regulatory activity of a polypeptide comprising the amino acid sequence as set forth in SEQ ID NO: 2. The one or more amino acid substitutions are selected from the group consisting of H98Y, E102K, E108K, E120K, and combinations thereof. | 2008-12-25 |
20080318859 | Methods for Tissue Engineering - The invention relates to the use of parathyroid hormone-related protein (PTHrP) in the prevention of hypertrophy in chondrogenic cells for cartilage replacement. A method for engineering three dimensional cartilage constructs from chondrogenic cells is provided, said method comprising a step of treating the chondrogenic cells or immature constructs with PTHrP to regulate hypertrophy. Also provided are: three dimensional cartilage produced by the method of the invention, and an engineered cartilage construct comprising chondrogenic cells and a bioactive scaffold capable of controlled release of PTHrP. In addition, the invention provides a method for the treatment of osteoarthritis. | 2008-12-25 |
20080318860 | High Activity Growth Factor Mutants - The application relates to novel biosynthetic growth factor mutants, derived from GDF-5, which exhibit improved biological activity. Mutations at positions 453 and 456 of human GDF-5 are disclosed, as well as use of these mutants in therapy of diseases associated with tissue degeneration/destruction. | 2008-12-25 |
20080318861 | Mucosal Delivery of Stabilized Formulations of Exendin - What is described is a pharmaceutical formulation for intranasal administration of exendin to a mammal, wherein the formulation comprises a therapeutically effective amount of an exendin, a viscosity enhancer, methyl-β-cyclodextrin, a surfactant, tartrate buffer to control pH and a chelating agent for cations, and wherein such exendin dosage form exhibits at least 95% exenatide recovery after storage for at least 365 days at 5° C. | 2008-12-25 |
20080318862 | CROSSLINKABLE POLYMERIC MATERIALS AND THEIR APPLICATIONS - The present invention relates to a novel composition for dental, orthopedic and drug delivery purpose. Specifically, it relates to composition comprising an admixture of a resorbable bone substitute and a crosslinkable prepolymer. It also relates to the composition formed by crosslinking the admixture. | 2008-12-25 |
20080318863 | ISCHEMIA THERAPEUTIC AGENT - The present invention provides a ischemia therapeutic agent that contains vascularization induction factor and gelatin hydrogel, and gradually releases vascularization induction factor, which is useful in treating ischemia accompanying peripheral circulatory disorders etc. encountering as complications of arteriosclerosis obliterans, Buerger's disease, diabetes and collagen disease. | 2008-12-25 |
20080318864 | METHODS AND COMPOSITIONS REGARDING POLYCHALCOGENIDE COMPOSITIONS - The present invention concerns the use of polychalcogenide compositions on cells, tissue, organs, and organisms to enhance their survivability. It includes compositions, compounds, methods, articles of manufacture and apparatuses for enhancing survivability and for protecting them from or treating them for injury or damage. In specific embodiments, there are also therapeutic methods and apparatuses for hypoxic/ischemic injury, organ transplantation, hyperthermia, wound healing, hemorrhagic shock, cardioplegia for bypass surgery, neurodegeneration, hypothermia, and cancer using the polychalcogenide compositions described. | 2008-12-25 |
20080318865 | Stabilized Pharmaceutical Peptide Compositions - Method for increasing the shelf-life of a pharmaceutical composition comprising a glucagon-like peptide which is prepared from a peptide product that has been dried at a pH above neutral pH. | 2008-12-25 |
20080318866 | MEDICAMENT FOR TREATMENT OF NON-INSULIN DEPENDENT DIABETES MELLITUS, HYPERTENSION AND/OR METABOLIC SYNDROME - A substance including the chemical structures of bicyclo [3.2.1]octan or the chemical structures of kaurene for the use in a dietary supplementation or as a constituent in a medicament for the treatment of non-insulin dependent diabetes mellitus, hypertension and/or the metabolic syndrome. The unique chemical structures of bicyclo [3.2.1]octan alone or in a kaurene structure provides the substances, such as e.g. steviol, isosteviol and stevioside with the capability of enhancing or potentiating the secretion of insulin in a plasma glucose dependent manner. The substances including these unique chemical structures also have the capability of reducing the glucagon concentration in the blood and/or lowering the blood pressure thereby providing a self-regulatory treatment system for non-insulin dependent diabetes mellitus and/or hypertension. In a combination drug which also comprise a soy protein, and/or soy fiber and/or at least one isoflavone these substances act synergistically and such combination drugs are highly useful both prophylacticly or directly in the treatment of e.g. the metabolic syndrome and obesity and has due to the self-regulatory effect a widespread applicability as a dietary supplementation. | 2008-12-25 |
20080318867 | Virulent Phages to Control Listeria Monocytogenes in Foodstuffs and in Food Processing Plants - The present invention relates to virulent (lytic) | 2008-12-25 |
20080318868 | Use of Mycobacterial Mannosylated Lipoglycans Peptide Mimotopes For Treating Inflammation - The present invention is based on the discovery that biological peptide-based mimotopes of mannose-containing cell-wall compounds of | 2008-12-25 |
20080318869 | Method to Promote Wound Healing - Wound healing is impaired in irradiated animals. Substance P and its active analogs promote wound healing in irradiated animals. Substance P and its analogs can be used to treat animals irradiated by a nuclear weapon, a nuclear accident, or a therapeutic regimen, for example. Wounds which are susceptible to such treatment include surgical wounds, weapons wounds, disease-caused wounds, bed sores, diabetic ulcers, etc. | 2008-12-25 |
20080318870 | SYNTHETIC BILE ACID COMPOSITIONS AND METHODS - Bile acids and related compositions and methods of synthesis and use. More specifically, deoxycholic acid and related compositions, said compositions being free of all moieties of animal origin and free of pyrogenic moieties. | 2008-12-25 |
20080318871 | Treatment of neurological disorders - The description relates to the treatment of the inflammatory component of neurological disorders or so called neuroimmune disorders such as schizophrenia, manic depression and other bipolar disorders, multiple sclerosis, post-partum psychosis and autism, herein also called inflammatory neurological disorders. Provided are methods for modulating a neurological disorder in a subject comprising providing the subject with a gene-regulatory peptide or functional analogue thereof. Also provided is use of an NF-kappaB down-regulating peptide or functional analogue thereof for the production of a pharmaceutical composition for the treatment of a neurological disorder. | 2008-12-25 |
20080318872 | Antigen determinant of rheumatoid arthritis-specific autoantibody and use thereof - A dipeptide antigen determinant is disclosed where haptenic Cit and Cys residues are connected by means of a peptide bond having the formula III: | 2008-12-25 |
20080318873 | CAMPTOTHECIN DERIVATIVES AS CHEMORADIOSENSITIZING AGENTS - Camptothecin-based compounds are useful for treating a neoplasm in mammalian subjects by administering such compound to the subjects in combination with radiotherapy, i.e., the treatment of tumors with radioactive substances or radiation from a source external to the subject. Camptothecin-based compounds are modified by positioning at least one electron-affinic group around the camptothecin structure to enhance their value in combination with radiotherapy. New Camptothecin-based compounds are disclosed that are useful for treating cancer by administering the novel compounds alone or in combination with radiotherapy. | 2008-12-25 |
20080318874 | Novel Cyclohexane Derivative, Prodrug Thereof and Salt Thereof, and Therapeutic Agent Containing the Same for Diabetes - A cyclohexane derivative having the function of reducing a blood sugar level and having preferable properties required of medicines, such as long-lasting drug activity, metabolic stability, and safety; and a medicinal composition for use in the prevention or treatment of diseases attributable to hyperglycemia, such as diabetes, e.g., insulin dependent diabetes mellitus (type 1 diabetes) or noninsulin-dependent diabetes mellitus (type 2 diabetes), complications of diabetes, and obesity. The derivative is a compound represented by the formula (I): | 2008-12-25 |
20080318875 | Core 2 Glcnac-T Inhibitors - The present invention relates to the use of known and novel compounds as inhibitors of UDP-GlcNAc:Galβ1,3GaINAc-R (GlcNAc to GalNAc) β1,6-N-acetylglucosaminyl transferase (core 2 β1,6 N-acetylaminotransferase, core 2 GlcNAc-T-EC 2.4.1.102). Such inhibitors have applications in therapy for diseases associates with raised activity of core 2 GlcNAc-T, in particular inflammatory diseases, atherosclerosis, diabetic cardiomyopathy, cancers—including treatment or prevention of metastasis—or diabetic retinopathy. | 2008-12-25 |
20080318876 | Use of Ginsenosides in the Treatment of Aids - The present invention relates to the use of compounds of formula (I) in the treatment of AIDs, | 2008-12-25 |
20080318877 | PURIFICATIONS OF POMEGRANATE ELLAGITANNINS AND THEIR USES THEREOF - Compositions of purified and biologically active ellagitannins are provided by separation from pomegranate husk using a method of extraction and purification using a solid polymeric adsorbent and the uses of the said compounds | 2008-12-25 |
20080318878 | Antibacterial Agents - The present invention provides acylide derivatives, which can be used as antibacterial agents. Compounds disclosed herein can be used for treating or preventing conditions caused by or contributed to by Gram-positive, Gram-negative or anaerobic bacteria, more particularly against, for example, Staphylococci, Streptococci, Enterococci, | 2008-12-25 |
20080318879 | Method for the Preparation of Polymeric Conjugates of Doxorubicin with Ph-Controlled Release of the Drug - A method for the preparation of polymeric conjugates of N-(2-hydroxypropyl)methacrylamide and a methacryloylaminoacylhydrazone of doxorubicin with pH-controlled release of the drug, comprising the following three steps of synthesis: a. preparation of a monomeric methacryloylaminoacylhydrazine, wherein the aminoacyl is derived from an amino acid or oligopeptide, by reaction of a methacryloyl halide with the respective peptide, amino acid, or a derivative thereof, and subsequent hydrazinolysis, b. synthesis of a polymeric precursor by direct copolymerization of N-(2-hydroxypropyl)methacrylamide with the methacryloylaminoacylhydrazine, and c. binding of doxorubicin to the polymeric precursor by reaction thereof with doxorubicin hydrochloride. | 2008-12-25 |
20080318880 | Neoadjuvant treatment of Breast Cancer - Neoadjuvant treatment of inflammatory or T3 to T4 breast cancer is carried out by administering to such patients a number of cycles of chemotherapy treatment in which DPPE first is administered followed by a combination of anthracyclines and taxanes. | 2008-12-25 |
20080318881 | Liquid Compositions For Treating Plant Propagation Materials - The present invention includes a fast-drying liquid composition comprising at least one fungicide and at least one insecticide. The present invention further includes a method for treating plant propagation materials, especially cut seeds, including tubers, against pests, a method for promoting suberization in cut seeds, a method for decreasing the drying time of a liquid pesticide on cut seeds, and a method for selectively loading a pesticide onto the skin side of a cut seed. | 2008-12-25 |
20080318882 | Method of Delivery of Nucleic Acids to Peripheral Neurons - The invention provides for methods for delivering a nucleic acid into a peripheral neuron by identifying a target neuron in a dorsal root ganglion and intrathecally delivering a vector comprising the nucleic acid to the dorsal root ganglion neuron. The nucleic acid may encode a neurotrophic factor that may be used to treat a peripheral neuropathy or, in conjunction with a nerve guide conduit, to treat a transected peripheral nerve. | 2008-12-25 |
20080318883 | Anti-aging supplement - An anti-aging supplement is disclosed having effective amounts of β1,3D glucan, deoxyribonucleic acid, and body's hyaluronan-yielding row material composed of at least one amino sugar selected from a group consisting of N-acetylglucosamine and glucosamine salts. | 2008-12-25 |
20080318884 | Methods for Altering Gene Expression and Methods of Treatment Utilizing Same - The present disclosure describes methods for altering the expression of a target gene comprising a rare cluster of codons, including, but not limited to, trinucleotide repeats. The method utilizes, in part, on amino acid deprivation or the limiting of specific charged tRNAs. The methods for altering target gene expression may be used in treatment methods to treat diseases in a subject organism in need of such treatment. Such methods for altering target gene expression have not been heretofore recognized in the art. Exemplary diseases that may be treated using the methods of the present disclosure include any disease where altering the expression of the target gene would provide treatment. Such diseases include all forms of cancer, ageing, infectious disease, metabolic disorders, inflammation, neurological disorders, diabetes, psychiatric disorders and diseases associated with trinucleotide repeats. | 2008-12-25 |
20080318885 | Method for Modulating Responsiveness to Steroids - The present invention makes it possible to enhance steroid efficacy in a steroid refractory patient afflicted with an inflammatory condition not responding or responding poorly or inadequately to anti-inflammatory treatment, by administering an effective amount of an oligonucleotide having the sequence | 2008-12-25 |
20080318886 | Methods of Increasing Cancer Sensitivity to Chemotherapeutic Agents Using Chimeric ISF35 - A method of treating cancer by administering ISF35 or analogous constructs. The treatment can allow an increased sensitivity to treatment with a chemotherapeutic agent. | 2008-12-25 |
20080318887 | Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin - Compositions and methods for modulating tumor proliferation in an individual are provided. The methods employ nucleolin-binding agents, such as aptamers. The aptamers of the present invention can be used to modulate the proliferation of malignant, dysplastic, hyperproliferative, and/or metastatic cells through interference with molecular interactions and functions of nucleolin in the tumor cell. | 2008-12-25 |
20080318888 | Antiproliferative activity of g-rich oligonucleotides and method of using same to bind to nucleolin - Compositions and methods for modulating tumor proliferation in an individual are provided. The methods employ nucleolin-binding agents, such as aptamers. The aptamers of the present invention can be used to modulate the proliferation of malignant, dysplastic, hyperproliferative, and/or metastatic cells through interference with molecular interactions and functions of nucleolin in the tumor cell. | 2008-12-25 |
20080318889 | Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin - Compositions and methods for modulating tumor proliferation in an individual are provided. The methods employ nucleolin-binding agents, such as aptamers. The aptamers of the present invention can be used to modulate the proliferation of malignant, dysplastic, hyperproliferative, and/or metastatic cells through interference with molecular interactions and functions of nucleolin in the tumor cell. | 2008-12-25 |
20080318890 | Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin - Compositions and methods for modulating tumor proliferation in an individual are provided. The methods employ nucleolin-binding agents, such as aptamers. The aptamers of the present invention can be used to modulate the proliferation of malignant, dysplastic, hyperproliferative, and/or metastatic cells through interference with molecular interactions and functions of nucleolin in the tumor cell. | 2008-12-25 |
20080318891 | Antisense oligonucleotides against thymidylate synthase - Antisense oligonucleotides targeted to sequences in thymidylate synthase (TS) mRNA. In particular the invention relates to antisense oligonucleotides targeted to sequences in the 3′ end of TS mRNA, which are both cytostatic on their own when administered to human tumour cell lines, and which also enhance the toxicity of anticancer drugs. The invention further relates to a combination product comprising an antisense oligonucleotide in combination with an anticancer agent such as Tomudex or pemetrexed and to the use of such a combination product in the treatment of cancer. | 2008-12-25 |
20080318892 | METHODS AND FORMULATIONS FOR PROTECTING CELLS, AND FOR TREATING DISEASES AND CONDITIONS BY OPTIMIZING THE INTRACELLULAR CONCENTRATION OF NAD - Pharmaceutical and cosmetic formulations and methods for optimizing the intracellular concentrations of NAD are provided. The present methods and compounds relate to the use of PBEF, PRPP and various forms of nicotinamide, individually or in combination, for therapeutic, cyto-protective, cosmetic and anti-aging purposes. PBEF, PRPP and nicotinamide, individually or in combination, as administered according to the invention, increase the metabolic fitness, health and performance of the cell, and thereby increase the cell's level of health during its lifecycle. By way of the present formulations and methods, optimizing the intracellular concentration of NAD+ facilitates a balance among the numerous intracellular interactions of NAD+, and its related pathways, such that the health of the cell and its resistance to stress and trauma are increased. This increased robustness attendant to the invention also facilitates the delay of apoptosis. | 2008-12-25 |