52nd week of 2008 patent applcation highlights part 45 |
Patent application number | Title | Published |
20080318190 | Polymerizable Dental Pulp Healing, Capping, and Lining Material and Method for Use - Dental pulp healing lining or capping compositions and methods of using the composition to treat an exposed, nearly exposed, or breached pulp chamber are disclosed herein. Embodiments include dental pulp healing lining or capping compositions comprising a resin portion having at least one hydrophilic monomer component and at least one hydrophobic monomer component and a calcareous material operable to both provide a biological seal and maintain an alkaline pH for extended periods. Further, light curable compositions are disclosed, allowing for improved curing properties, and allowing permanent restorations to be adhered to the sealed tooth without waiting a significant amount of time for the Portland cement portion to cure. | 2008-12-25 |
20080318191 | Braille type device, system, and method - A Braille type device including printed or displayed matter on a medium in combination with printed or displayed Braille type code, preferably machine readable Braille type bar code. The Braille type system includes the combination of the Braille type device and a Braille type-scanning device. The Braille type method includes printing or displaying a Braille type bar code on a medium. | 2008-12-25 |
20080318192 | Training Apparatus - The invention relates to an apparatus, for training a user to develop one or more actions which may facilitate improved compliance to an event by the user. It comprises: • a screen for displaying information relating to the event to the user; and • a user interface, enabling the user to control a program which demonstrates the one or more actions to the user in the context of the event. The apparatus is programmed to demonstrate the one or more actions through one or more characters and the user is able to observe the one or more actions and optionally control the event outcome, by being able to control the one or more, actions of the one or more characters. Preferably each different action is demonstrated by a different character such that the user associates a specific action with a specific character and can thus be, prompted in an event situation to act in a given way, by reference to the specific character. | 2008-12-25 |
20080318193 | MEDICAL TRAINING AID DEVICE FOR TRAINING A USER IN RECOGNITION OF THE USER'S BODILY FLUID ANALYTE CONCENTRATION AND CONCENTRATION TRENDS VIA USER-PERCEIVED SENSATIONS - A device for training a user in recognition of the user's bodily fluid analyte concentration and concentration trends (such as the user's whole blood glucose concentration and concentration trends) includes an analyte monitoring module, a control module and a sensation generation module. The analyte monitoring module is configured to monitor the user's bodily fluid analyte concentration and to output a monitor signal corresponding to the user's bodily fluid analyte concentration. The control module is configured to receive the monitor signal, convert the monitor signal into a sensation instruction signal corresponding to the user' bodily fluid analyte concentration, and output the sensation instruction signal. The sensation generation module configured to receive the sensation instruction signal and to generate a user-perceived sensation (e.g., a user-perceived vibratory sensation) corresponding to the user's bodily fluid analyte concentration. Moreover, the user-perceived sensation is proportional to the user's bodily fluid analyte concentration in a predetermined manner and is generated at predetermined time intervals. | 2008-12-25 |
20080318194 | KIT FOR TEACHING THE COMPOSITION OF BLOOD - A kit for fabricating various visual models is used to teach students about blood, blood pathology, and the quantitative concepts associated with blood pathology. The kit includes various sized containers that hold colored beads that resemble red blood cells and the various types of white blood cells. | 2008-12-25 |
20080318195 | Human spine model - Human spine model with a plurality of rigid disks each having radial elongate members that represent vertebrae, a plurality of resilient disks that represent spinal disks and a plurality of elastic band members that represent connecting muscle, all mounted on top of a housing. The rigid disks are alternately interspersed with the resilient disks thereby forming a column. The rigid disks and the resilient disks each have a centrally located aperture. The resilient disks are translucent and each have an LED imbedded within. When a rotary knob is rotated by a user a take up spindle within the housing pulls on a flexible cable traveling through the center of the disks causing a pre recorded audio message and the LED's to activate and causing the resilient disks to compress and bulge outward. The elastic bands connect one elongate member to another simulating muscle tissue. | 2008-12-25 |
20080318196 | DAL self service school library - DAL education system, support education and teaching students in the third world. The DAL Education system is comprised of three systems/I, II, III/, to fit the request and the affordable schools need at the third word countries. The first DAL Education system/I/use kiosk self-service DAL e-library with DAL e-Book reader to be read throw domestic TV screen, the second DAL Education system/II/use, DAL Library keeper special software with DAL e-Book reader to be read throw domestic TV screen, the third DAL Education system/III/use, small cheap self-service DAL e-Magazine or monthly Author e-book library, with DAL e-Book reader to be read throw domestic TV screen. The DAL EDU. System made the e-book reading cheap easy and affordable to the third world students, this will support and increase the quality education to make the standard living third world people much better, as learning is the key to success in life. | 2008-12-25 |
20080318197 | Method and system for education compliance and competency management - The present invention discloses a method, system, and computer product for complete and comprehensive education competency and compliance management method and system for institutions and organizations. The embodiments of the present invention disclose a method whereby a sponsoring organization or institution need only provide secure access to the hosting organizations content delivery for ease of capture, organization of and reporting on the entire educational program. The sponsoring organization is able to direct employees to educational activities required to be completed based on the compliance requirements for their role in the organization. The hosting organization remains content independent to objectively provide the “best value” content for sponsoring organizations. Sponsoring organizations can purchase content from content partners or other third parties for loading the on-line and off-line education competency and compliance management servers, generate reports for internal use and accrediting bodies updates. | 2008-12-25 |
20080318198 | System and method for draft selection and participation therein - A fan-based draft is disclosed whereby fans select an | 2008-12-25 |
20080318199 | COMPUTER SYSTEMS AND METHOD FOR EDUCATIONAL USE - The present disclosure provides a computer system and associated usage method solely for educational purposes. The computer system is a computer appliance focused solely for educational use operating only educationally approved programs and loading only educationally approved content. Advantageously, such appliance provides a secure and focused platform for learning that can be used at home by parents and students and in class by teachers, parents, and students. | 2008-12-25 |
20080318200 | Computer-Aided Method and System for Guided Teaching and Learning - The present invention is a computer aided method and system for guided teaching and learning with the aid of an optional communication device, comprising the steps of: (a) presenting a question to the student at a student display; (b) receiving answer from the teacher at the teacher workstation, wherein the answer is received by the teacher from the student or directly from the students remotely; (c) sharing the answer submitted on at least one student displayed) determining whether the answer is correct; (e) presenting feedback to the answer at all student displays or workstations; (f) receiving input from the teacher at the teacher workstation for the teacher to give further information related to the question on student display; and (g) presenting information using a plurality of styles and stimuli corresponding to the input from the teacher or student on the student display. | 2008-12-25 |
20080318201 | COMPONENT-BASED DISTRIBUTED LEARNING MANAGEMENT ARCHITECTURE - The present invention provides a distributed learning management architecture that is “componentized” for increased distribution and scalability. Specifically, the present invention provides an architecture in which multiple content servers, delivery servers and/or live session servers can be provided to accommodate multiple geographic locations. The present invention further provides an off-line learning architecture that allows the teachings of the distributed learning management architecture to be implemented on an individual client. | 2008-12-25 |
20080318202 | CHIMERIC PANCREAS - Novel methods, tissues and compositions for increasing the pancreatic mass of a mammalian recipient including harvesting immature pancreatic tissue from a mammalian donor and transplanting said tissue into the peritoneal cavity of a mammalian recipient under conditions that allow the pancreatic tissue to become vascularized and mature, thereby developing a functioning chimeric, endocrine pancreas that produces at least insulin in the recipient. The invention also includes mammalian immature pancreatic tissue adapted for transplantation into the peritoneal cavity of a mammalian recipient for increasing the pancreatic mass of the mammalian recipient as well as methods and compositions for treatment of the pancreatic tissue, recipient immunosuppression and recipient co-stimulatory blockade. | 2008-12-25 |
20080318203 | Novel Microfluidic System and Method for Capturing Cells - The invention concerns a microfluidic device and its uses for capturing subset of cells in a biological fluid. Said device comprises a chamber ( | 2008-12-25 |
20080318204 | Highly-Sensitive Genomic Assays Employing Chimeric Bacteriophage Standards - Methods are provided for sensitively quantitating at least one pre-selected DNA sequence in a biological sample utilizing hybridization methodology, the method employing as an internal standard an infectious bacteriophage particle comprising a detectable target DNA sequence other than that present in the pre-selected DNA sequence or in DNA quantitated from the biological sample, and as an external standard, an infectious bacteriophage particle comprising at least the pre-selected DNA sequence. | 2008-12-25 |
20080318205 | Hiv Type and Subtype Detection - The present invention relates to the detection of HIV by amplification and PCR-based methods. | 2008-12-25 |
20080318206 | DETECTION OF HERPES SIMPLEX VIRUS TYPES 1 AND 2 BY NUCLEIC ACID AMPLIFICATION - The present invention relates to a method of detecting the presence or absence of herpes simplex virus (HSV) in a sample based on amplifying a portion of the Glycoprotein G (US4) gene of HSV and detecting the presence of the amplified nucleic acid using primers and detector primers as described herewith. The method of the invention further identifies the type of HSV, either HSV-1 or HSV-2, in a sample. Also encompassed by the invention is a kit comprising the primers and detector primers which may be used with the amplification method described herewith. | 2008-12-25 |
20080318207 | SEQUENCE COVARIANCE NETWORKS, METHODS AND USES THEREFOR - Methods of identifying targets for designing a therapeutic agent are disclosed. These methods comprise: determining an amino acid sequence of one or more polypeptides of each isolate of a plurality of isolates of a biological system; identifying covariance pairs of amino acid residues; establishing a network comprising the covariance pairs; and identifying one or more hub residue positions, wherein a hub residue position comprises a target for designing a therapeutic agent if the hub residue position has a rank order in the 40 | 2008-12-25 |
20080318208 | Dengue Reporter Virus and Methods of Making and Using the Same - The present invention relates to the production and uses of Dengue virus replicons and Dengue reporter virus particles. The present invention relates to methods of identifying inhibitors of Dengue virus infection, inhibitors of Dengue virus replication, and inhibitors of Dengue virus assembly. | 2008-12-25 |
20080318209 | Cjd Prion Testing - The present invention provides an assay method for detecting infectious prion protein in a sample from a mammalian subject, said method comprising: obtaining a prion protein containing sample from said subject; contacting said sample with an agent which serves to digest non-infectious prion protein and to partially digest infected prion protein to yield a prion protein polypeptide residue; contacting the digested sample with an antibody capable of binding to a poly peptide having the amino acid sequence Vc (Gly-Gly-Gly-Trp)-Gly-Gln-Gly-Gly-R | 2008-12-25 |
20080318210 | BIOINFORMATICALLY DETECTABLE GROUP OF NOVEL REGULATORY VIRAL AND VIRAL ASSOCIATED OLIGONUCLEOTIDES AND USES THEREOF - The present invention relates to a first group of novel viral and human associated oligonucleotides, here identified as Genomic Address Messenger or GAM oligonucleotide, and a second group of novel operon-like viral and human polynucleotides, here identified as Genomic Record or GR polynucleotide. GAM oligonucleotides selectively inhibit translation of known ‘target’ genes, many of which are known to be involved in various viral diseases. Nucleic acid molecules are provided respectively encoding 15484 GAM precursors oligonucleotides, and 699 GR polynucleotides, as are vectors and probes both comprising the nucleic acid molecules, and methods and systems for detecting GAM oligonucleotides and GR polynucleotides and specific functions and utilities thereof, for detecting expression of GAM oligonucleotides and GR polynucleotides, and for selectively enhancing and selectively inhibiting translation of the respective target genes thereof. | 2008-12-25 |
20080318211 | Color-encoding and in-situ interrogation of matrix-coupled chemical compounds - Disclosed is a method for the physico-chemical encoding of a collection of beaded resin (“beads”) allowing determination of the chemical identity of bead-anchored compounds, following identification of beads bearing compounds of interest in an assay, by in-situ interrogation of individual beads, which does not require isolation of the beads of interest. These methods can be used to implement color-coding strategies in applications and including the ultrahigh-throughput screening of bead-based combinatorial compounds libraries as well as multiplexed diagnostic and environmental testing and other biochemical assays. | 2008-12-25 |
20080318212 | Orphan Receptor Tyrosine Kinase as a Target in Breast Cancer - Methods and materials relating to the orphan receptor tyrosine kinase (ROR1) are described. ROR1 exhibits restricted tissue expression in normal adult tissue and is overexpressed in certain breast cancer subtypes. ROR1 provides a diagnostic and/or therapeutic target for breast cancers. | 2008-12-25 |
20080318213 | Mass Spectrometer - A mass spectrometer and a method of spectrometry are disclosed wherein liquid chromatography mass spectral data are probabilistically clustered on the basis of mass to charge ratio and retention time. | 2008-12-25 |
20080318214 | Genome Analysis Method - This invention makes it possible to perform analysis for estimating the characteristics of a population using sample data. By obtaining sample data, embedding genetic (statistical) knowledge in a first and second state variable that have duality, and having the first and second state variables converge to the original value, the characteristics of the population of the sample data are estimated, and the estimated results of the characteristics of the population are output. By doing so, it is possible to perform analysis for estimating characteristics of a population using sample data. | 2008-12-25 |
20080318215 | APPARATUS, METHODS AND PRODUCTS FOR DETECTING GENETIC MUTATION - Methods for detecting genetic mutation allowing detection of very low frequency mutation. Methods comprise treating RNA:DNA heteroduplexes of interest with ribonuclease treatment coupled with DNA polymerase treatment. RNA:DNA heteroduplexes of interest are preferentially targeted for digestion by ribonuclease and subsequent sequence extension by DNA polymerase. Methods may be carried out partially or entirely manually, automatically, and combinations thereof. Methods may be performed wholly or partially in solution, on solid phase media, in large scale, adapted for high throughput analysis, and any combinations thereof. Apparatus and products for detecting genetic mutation. | 2008-12-25 |
20080318216 | Methods For Determining Presence of Cancer by Analyzing the Expression of Cdk9 and/or Cyclin T1 in Lymphoid Tissue - A method for determining presence of lymphoma in a patient is disclosed. A sample of bone marrow, thymus, spleen, lymph nodes, lymph and/or lymphocytes taken from the patient t is assayed to determine expression of CDK9 and CYCLIN T1. The presence of CDK9 and/or CYCLIN T1 is indicative of a lymphoma other than a mantle cell lymphoma or marginal zone lymphoma in the patient. | 2008-12-25 |
20080318217 | Identification of Gene Associated with Reading Disability and Uses Therefor - The present invention relates to identification of a human gene, DCDC2 (MIM: 605755), associated with susceptibility for developing reading disability (RD), which is useful in identifying or aiding in identifying individuals at risk for developing RD, as well as for diagnosing or aiding in the diagnosis of RD. | 2008-12-25 |
20080318218 | Compositions and Methods for Inferring an Adverse Effect in Response to a Drug Treatment - Methods are provided for inferring whether a subject to be treated with a drug such as a statin or an ACE inhibitor is likely to suffer an adverse effect due to the treatment. Also provided are compositions for practicing the methods. | 2008-12-25 |
20080318219 | METHODS AND COMPOSITIONS FOR PREDICTING DRUG RESPONSES - The present invention relates to methods and compositions for predicting drug responses. In particular, the present invention provides methods and compositions for determining individualized Warfarin dosages based on genotype of DNA polymorphisms and haplotypes derived from them in the VKORC1 gene. | 2008-12-25 |
20080318220 | METHOD FOR THE DIAGNOSIS AND/OR PROGNOSIS OF ALZHEIMER'S DISEASE - The present invention relates to a method for the diagnosis and/or prognosis of Alzheimer's disease by means of determining the ZMIZ1 gene expression level in a biological sample and comparing said level with a reference value, in which the alteration of said level is indicative of Alzheimer's disease. | 2008-12-25 |
20080318221 | METHOD FOR THE DIAGNOSIS AND/OR PROGNOSIS OF ALZHEIMER'S DISEASE - The present invention relates to a method for the diagnosis and/or prognosis of Alzheimer's disease by means of determining the DARC gene expression level in a biological sample and comparing said level with a reference value, in which the disturbance of said level is indicative of Alzheimer's disease. | 2008-12-25 |
20080318222 | Cell Based Methods And Systems For The Identification Of Rna Regulatory Sequences And Compounds That Modulate Their Functions - The present invention is directed to an in vivo method for screening for and/or identifying RNA regulatory sequences involved in translational control. The method includes: culturing cells including: (i) a translational system; (ii) a reporter mRNA; and (iii) an RNA test sequence under suitable conditions for translation of the reporter mRNA, wherein the RNA test sequence is not attached to the reporter mRNA. The method also includes measuring the effect of the test sequence on the translation of the reporter mRNA, wherein a test sequence that modifies the translation of the reporter mRNA includes an RNA regulatory element. The invention also provides methods and systems for screening for and/or identifying test compounds that modulate the regulatory activity of an RNA regulatory sequence. This method includes culturing cells including (i) a translation system; (ii) a reporter mRNA; and (iii) an RNA regulatory sequence in the presence of at least one test compound, wherein the RNA regulatory sequence is not attached to the reporter mRNA. The ability of the test compound to affect the interaction between the RNA regulatory sequence and at least one component of the translation system is sought to be determined. The method further includes monitoring for the effect of the test compound on the this interaction, wherein a compound that modifies this interaction is a drug candidate. | 2008-12-25 |
20080318223 | LARGE DELETIONS IN HUMAN BRCA1 GENE AND USE THEREOF - Large deletions have been identified in the BRCA1 gene in patients. The large deletions predispose the patients to breast cancer and ovarian cancer. Thus, methods for detecting the genetic variants are provided which can be used in detecting a predisposition to cancer. | 2008-12-25 |
20080318224 | LARGE DELETIONS IN HUMAN BRCA1 GENE AND USE THEREOF - Large deletions have been identified in the BRCA1 gene in patients. The large deletions predispose the patients to breast cancer and ovarian cancer. Thus, methods for detecting the genetic variants are provided which can be used in detecting a predisposition to cancer. | 2008-12-25 |
20080318225 | COMPOSITIONS AND METHODS FOR DETECTING CANCER - The present invention provides methods and compositions involving detecting the presence of and/or assessing the risk of cancer in a subject. These methods include methods of detecting and diagnosing cancer in an individual; methods of identifying individuals at risk of developing a cancer; and methods of staging a cancer. The methods generally involve detecting a palladin gene nucleotide sequence alteration that has been found to be associated with cancer and/or detecting a level of a palladin mRNA and/or protein in a biological sample. The present invention further provides nucleic acid probes, nucleic acid primers, and antibodies, as well as kits comprising one or more of the same, for use in a subject method. | 2008-12-25 |
20080318226 | Signal Amplification Method - Provided are a signal amplification method of improving signal sensitivity, qualifying properties and handling property in detection of a target gene by using a PALSAR method, a method of detecting a target gene by using the method, and an oligonucleotide probe to be used in the method. A signal amplification method in detection of a target gene using a polymer formed by the use of a plurality of kinds of oligonucleotide probes having complementary base sequence regions capable of hybridizing with each other, including labeling at least one of the plurality of kinds of oligonucleotide probes with acridinium ester for detection. | 2008-12-25 |
20080318227 | Intermediates and enzymes of the non-mevalonate isoprenoid pathway - The invention provides a protein in a form that is functional for the enzymatic conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate to 1-hydroxy-2-methyl-2-butenyl 4-diphosphate notably in its (E)-form of the non-mevalonate biosynthetic pathway to isoprenoids. The invention also provides a protein in a form that is functional for the enzymatic conversion of 1-hydroxy-2-methyl-2-butenyl 4-diphosphate, notably in its (E)-form, to isopentenyl diphosphate and/or dimethylallyl diphosphate. Further, screening methods for inhibitors of these proteins are provided. Further, 1-hydroxy-2-methyl-2-butenyl 4-diphosphate is provided and chemical and enzymatic methods of its preparation. | 2008-12-25 |
20080318228 | Biomarkers and methods for determining sensitivity to microtubule-stabilizing agents - Biomarkers that are useful for identifying a mammal that will respond therapeutically or is responding therapeutically to a method of treating cancer that comprises administering a microtubule-stabilizing agent. In one aspect, the cancer is breast cancer, and the microtubule-stabilizing agent is an epothilone or analog or derivative thereof, or ixabepilone. | 2008-12-25 |
20080318229 | Method for Diagnosing Neuro-Degenerative Disease - A method for the diagnosis of Alzheimer's Disease (AD) or Parkinson's Disease (PD), comprises measuring the level of expression of one or more AD markers (Table 1) or PD markers (Table 2) in a sample of platelets isolated from a person suspected of having AD or PD, and determining whether the levels of expression are altered compared to a control. | 2008-12-25 |
20080318230 | GENE EXPRESSION MARKERS FOR RESPONSE TO EGFR INHIBITOR DRUGS - The present invention concerns prognostic markers associated with cancer. In particular, the invention concerns prognostic methods based on the molecular characterization of gene expression in paraffin-embedded, fixed samples of cancer tissue, which allow a physician to predict whether a patient is likely to respond well to treatment with an EGFR inhibitor. | 2008-12-25 |
20080318231 | 14-3-3 ZETA OVER-EXPRESSION AS A POOR PROGNOSIS FACTOR, AND A THERAPEUTIC TARGET IN MULTIPLE CANCER TYPE - Methods of determining prognosis in a subject with a hyperproliferative disease, including determining expression and/or function of 14-3-3 zeta in the subject, are disclosed. Also disclosed are methods of making a pharmaceutical agent that modulates apoptosis, including the steps of obtaining one or more candidate, testing the one or more candidate substances to determine their ability to modulate the expression and/or function of 14-3-3 zeta, selecting a candidate substance determined to modulate the expression and/or function of 14-3-3 zeta, and making a pharmaceutical composition that includes the selected candidate substance. In addition, methods of treating a subject with a hyperproliferative disease, including making a pharmaceutical agent by the methods set forth herein, and administering the pharmaceutical agent to a subject, are disclosed. The hyperproliferative disease can be cancer, such as breast cancer. | 2008-12-25 |
20080318232 | Nucleic Acid Biosensor with Photoelectrochemical Amplification - The present invention relates to electrode systems, methods, apparatus and chips for ultrasensitive detection and quantification of nucleic acids using photoelectrochemical amplification. Upon hybridization of a target nucleic acid to a nucleic acid capture probe, a photoreporter comprising a threading bis-intercalator selectively binds to double-stranded nucleic acid. The stability and reversibility of the photoreporter binding activity provides for ultrasensitive detection of nucleic acid hybridization events. | 2008-12-25 |
20080318233 | Source tagging and normalization of DNA for parallel DNA sequencing, and direct measurement of mutation rates using the same - This invention allows efficient tagging and normalization of DNA molecules prior to pooling and characterization using parallel DNA sequencing (e.g., commercially available 454 sequencers). The invention provides novel ways to process independent DNA samples (sources) so that similar numbers of molecules from each source are represented in the pool (i.e., the pool is normalized for representation among the sources). These approaches would save researchers time and energy relative to approaches currently available. In other embodiments, the invention provides novel ways to process large numbers of independently derived DNA samples that can be uniquely tagged in ways that allow the source of the DNA (e.g., an individual) to be tracked. The invention also provides novel ways for processing DNA to consistently obtain various portions of the genome to compare DNA sequences and directly measure mutations using state of the art massively parallel DNA sequencing (e.g., commercially available 454 sequencers and others. The invention is useful for the production of diagnostic assays for individuals prior to reproduction (e.g., cancer survivors who wish to procreate) and also for diagnostics of cancer (thus affecting the choice of treatment for cancer). | 2008-12-25 |
20080318234 | Compositions and methods for diagnosing and treating cancer - The present invention relates to compositions and methods for treating, characterizing, and diagnosing cancer. In particular, the present invention provides gene expression profiles associated with solid tumor stem cells, as well as novel stem cell cancer gene signatures useful for the diagnosis, characterization, prognosis and treatment of solid tumor stem cells. | 2008-12-25 |
20080318235 | Chromosomal Analysis By Molecular Karyotyping - The invention provides a method of karyotyping (for example for the detection of trisomy) a target cell to detect chromosomal imbalance therein, the method comprising: (a) interrogating closely adjacent biallelic SNPs across the chromosome of the target cell (b) comparing the result at (a) with the SNP haplotype of paternal and maternal chromosomes to assemble a notional haplotype of target cell chromosomes of paternal origin and of maternal origin (c) assessing the notional SNP haplotype of target cell chromosomes of paternal origin and of maternal origin to detect aneuploidy of the chromosome in the target cell. Also provided are related computer-implemented embodiments and systems. | 2008-12-25 |
20080318236 | Cell Free Screening Assay and Methods of Use - Methods are disclosed for identifying agents for the treatment of cancer and/or Fanconi anemia using | 2008-12-25 |
20080318237 | METHODS OF DIAGNOSING ENDOMETRIOSIS - The present invention provides biomarkers for the diagnosis and prognosis of endometriosis. Generally, the methods of this invention find use in diagnosing or for providing a prognosis for endometriosis by detecting the expression levels of biomarkers, which are differentially expressed (up- or down-regulated) in endometrial cells from a patient with endometriosis. Similarly, these markers can be used to diagnose reduced fertility in a patient with endometriosis or to provide a prognosis for a fertility trial in a patient suffering from endometriosis. The present invention also provides methods of identifying a compound for treating or preventing endometriosis. Finally, the present invention provides kits for the diagnosis or prognosis of endometriosis. | 2008-12-25 |
20080318238 | METHOD OF DETECTING GENE MUTATION - DNA amplification and hybridization are successively carried out in a reaction system containing primers for the DNA amplification and hybridization probes, followed by detecting the hybrid in the reaction solution by affinity chromatography, wherein at least one of the primers to be used in the DNA amplification is labeled with a first labeling agent so that the amplified DNA will be labeled with the first labeling agent, a hybridization probe is labeled with a second labeling agent and contained in a reaction solution for effecting the DNA amplification, the base sequence of the hybridization probe is designed not to inhibit the DNA amplification, and a hybrid is detected by affinity chromatography with the use of the first and second labeling agents. | 2008-12-25 |
20080318239 | COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF TUMOR - The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same. | 2008-12-25 |
20080318240 | METHODS FOR UTILIZING ESR COPY NUMBER CHANGES IN BREAST CANCER TREATMENTS AND PROGNOSES - The present invention relates to methods for estimation of efficacy of therapeutic treatment of cancer patients, in particular breast cancer patients. The estimation is based on determining of the status of aberration of the estrogen receptor alpha gene (ESR1) in situ, and, optionally, the status of aberration of a gene related to ESR1. In particular, the invention relates to determining the presence or absence and, if present, the type of aberration, e.g. amplification, duplication, polyploidization, deletion or translocation of the ESR1 gene in the tumor cells of the patient. The invention further relates to a kit-in-parts comprising probes for the determining the status of aberration of ESR1 and ESR1-related genes in situ. | 2008-12-25 |
20080318241 | Methods and Systems for Detecting Antiangiogenesis - The present invention provides methods and systems for the detection of tumor vessel response to antiangiogenic therapies. The present invention also provides compositions and methods for therapeutic and research applications. In particular, the present invention provides systems and methods that employ CD26, HIF-1, and HIF-1 pathway components as biomarkers for monitoring antiangiogenic therapies and as therapeutic targets. | 2008-12-25 |
20080318242 | METHODS AND DEVICES FOR EARLY DETECTION OF CANCER CELLS AND TYPES THROUGH MICROMECHANICAL INTERACTIONS - Methods and devices for detecting a cancer cell and cancer cell types in a sample of a subject are provided. | 2008-12-25 |
20080318243 | DNA measuring system and method - The present invention provides a DNA sequencer using a FET sensor, capable of long-base decoding. Target DNAs are immobilized on the surfaces of spherical fine particles, the fine particles are disposed in the vicinity of metal electrodes each of which is connected electrically to a corresponding one of conductive wirings of the FET sensor and partly has a spherical surface capable of contacting with the fine particles, and the FET sensor detects a change in interfacial potential incident to an extension reaction of DNA molecules containing a hybridization of the target DNA and probe DNA. | 2008-12-25 |
20080318244 | Large-scale parallel nucleic acid analysis method - It is intended to provide a technique for amplifying, individually and in parallel, nucleic acids contained in a mixture of plural kinds of nucleic acid samples. The present invention provides a nucleic acid analysis method comprising amplification means, whereby amplification reaction is performed in a reaction solution comprising a homogeneous solvent and comprising at least plural template nucleic acids and solid phase carriers comprising one or more kinds of amplification probes immobilized on the surface, to prevent amplified products attributed to two or more template nucleic acids from being replicated in one solid phase carrier. According to the present invention, plural kinds of analyte nucleic acid samples in a mixed state can be amplified individually and in parallel. This method achieves one solid phase carrier-one nucleic acid. Therefore, a higher density of solid phase carriers with obtained amplified products is easily achieved, leading to improved throughput of amplified product analysis. Reactions in all the amplification reaction steps are performed under homogeneous solvent conditions. Therefore, the method of the present invention is performed by convenient procedures and as such, is suitable to automation. | 2008-12-25 |
20080318245 | NANOTUBE STRUCTURES HAVING A SURFACTANT BILAYER INNER WALL COATING - Nanotubes and nanotube array structures comprise (a) a nanotube having an inner wall portion; and (b) a bilayer coating formed on the inner wall portions, with the bilayer coating comprised of surfactants. A secondary compound such as a protein, peptide or nucleic acid may be associated with the bilayer coating. The structures are useful for, among other things, affinity purification, catalysis, and as biochips. | 2008-12-25 |
20080318246 | Deeply quenched enzyme sensors - Sensors for detecting enzyme activity are provided that include a substrate module comprising a substrate for the enzyme of interest and a fluorescent label, a quencher, and a detection module. The detection module binds to the substrate module either before or after the enzyme acts on the substrate and sequesters the label from the quencher, resulting in an increased signal from the label. Sensors for detecting enzyme activity are also provided that include a substrate for the enzyme, a label, and a quencher that quenches the label. Action of the enzyme on the substrate results in a conformational change that relieves quenching. Sensors for detecting protein-protein interactions are also provided that include a quencher and a labeled first polypeptide. Binding of the first polypeptide to a second polypeptide sequesters the label from the quencher, resulting in an increased signal from the label. Methods using the sensors to detect enzyme activity and to screen for compounds affecting enzyme activity or to detect protein-protein interactions and to screen for compounds affecting protein-protein interactions, respectively, are also described. | 2008-12-25 |
20080318247 | Biomarker for cardiac transplant rejection - The invention provides a method of diagnosing a disease or disorder featuring an abnormal level of a ring-containing molecule in a tissue. In one embodiment, a method of diagnosing organ transplant rejection is provided. | 2008-12-25 |
20080318248 | Compositions and Methods of Screening Apoproteins - The present invention is directed to compositions and methods of screening apoproteins for the elucidation of modulators of metalation of apoproteins. | 2008-12-25 |
20080318249 | Methods and reagents to increase the sensitivity of enzyme metallographic detection - A test agent includes a composite probe having at least one nanoparticle having multiple metal atoms, a directing agent, and an enzyme. The directing agent attaches the probe to a target in a test sample. The test sample and bound probe are then treated with an enzyme substrate. A method of detecting a target in a test sample includes exposing the test sample to the probe, then treating the test sample with an enhancement or development solution to deposit at least one of a fluorophore, a chromogen, or a metal. | 2008-12-25 |
20080318251 | Mammalian Sweet And Amino Acid Heterodimeric Taste Receptors - The present invention provides isolated nucleic acid and amino acid sequences of sweet or amino acid taste receptors comprising two heterologous G-protein coupled receptor polypeptides from the T1R family of sensory G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet and amino acid taste receptors. | 2008-12-25 |
20080318252 | Rapid assay to test anti-cancer drugs under physiological conditions - This invention relates to an assay that allows for the rapid determination of the activity of a given drug against leukemic cells either taken from a patient or derived from a cell line. The assay is performed in the presence of whole blood or serum. | 2008-12-25 |
20080318253 | PSCA prostate stem cell antigen and uses thereof - The invention provides a novel prostate cell-surface antigen, designated Prostate Stem Cell Antigen (PSCA), which is widely over-expressed across all stages of prostate cancer, including high grade prostatic intraepithelial neoplasia (PIN), androgen-dependent and androgen-independent prostate tumors. | 2008-12-25 |
20080318254 | PSCA antibodies and hybridomas producing them - The invention provides a novel prostate cell-surface antigen, designated Prostate Stem Cell Antigen (PSCA), which is widely over-expressed across all stages of prostate cancer, including high grade prostatic intraepithelial neoplasia (PIN), androgen-dependent and androgen-independent prostate tumors. | 2008-12-25 |
20080318255 | Fluorescent Labeled Sphingosines - The present invention relates to a method (assay) for determining the activity of an enzyme selected from the group consisting of a sphingosine kinase and a phosphatase involved in the sphingolipid pathway by use of a labeled sphingosine. | 2008-12-25 |
20080318256 | Method for Stabilizing Coenzyme and Composition Therefor - Disclosed is a sugar and/or a sugar alcohol as a substance for suppressing dephosphorylation reaction of a phosphorylated coenzyme. Also disclosed is a method for stabilizing a phosphorylated coenzyme which is characterized by having at least a substance for suppressing dephosphorylation reaction of the phosphorylated coenzyme coexist with the phosphorylated coenzyme. | 2008-12-25 |
20080318257 | Polynucelotides encoding novel variants of the TRP channel family member, LTRPC3 - The present invention provides novel polynucleotides encoding LTRPC3g, LTRPC3h, LTRPC3i, LTRPC3j, LTRPC3k, or LTRPC3l polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel LTRPC3g, LTRPC3h, LTRPC3i, LTRPC3j, LTRPC3k, or LTRPC3l polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention. | 2008-12-25 |
20080318258 | Method for Measuring Cholesterol in Remnant-Like Lipoprotein - A method for measuring cholesterol in remnant-like lipoprotein in a sample, by a more convenient operation and with high sensitivity, and a reagent for the measurement are provided. | 2008-12-25 |
20080318259 | Hematocrit and Analyte Concentration Determination - A method to determine an analyte concentration of an anticoagulated plasma by performing at least two different measurements on a mixture of a blood sample corresponding to said anticoagulant plasma and of liquid reagent is described. The method comprises a) mixing a volume of said blood sample with a five-fold, or more, volume of said liquid reagent, b) performing said at least two measurements on said mixture, at least one of which correlates with the hematocrit of said blood sample and at least one of which correlates with said analyte concentration, and c) computing the results from the measurements when the volumes in a) are precise and accurate or when the hematocrit of said blood sample in b) is known to determine said analyte concentration of said anticoagulated plasma. In addition, a measurement and determination device for performing measurements on blood, anticoagulated blood and/or anticoagulated plasma samples, and an equipment kit are described. | 2008-12-25 |
20080318260 | Methods and Apparatus for Measuring Blood Coagulation - The present invention provides apparatus and methods for performing assays for determining the time required for a sample of blood to coagulate. The apparatus comprises reaction chambers coated with one or more clotting agent. A drop of blood or equivalent is placed at the sample application port, diluted, and contacted with the clotting agents in the reaction chambers. The diluted blood sample can be moved back and forth through the reaction chambers until blood clots. The blood clotting process forms fibrin stands that prevent the flow of the blood sample in the reaction chambers. The clotting time is the total time from the sample entering the reaction chambers to the time at which the waveform in the reaction chambers change, or the motion or flow of the sample ceases, and can be measured by turbidity. | 2008-12-25 |
20080318261 | Small Volume in Vitro Analyte Sensor - A sensor designed to determine the concentration of analyte in a sample having a volume of less than about 1 μL. The sensor has a working electrode coated with a redox mediator that acts as an electron transfer agent between the analyte and the electrode. A second electron transfer agent, such as an enzyme, can be added to facilitate the electrooxidation or electroreduction of the analyte. Various electrochemical detection methods, such as amperometric, voltammetric, and potentiometric techniques, can be used to determine the analyte concentration. The sensor can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum. | 2008-12-25 |
20080318262 | Protein Cleavage at Aspartic Acid Using Chemical Reagents - The present invention relates to the methods of identifying and quantifying polypeptides in a given sample by mass spectrometric analysis. More specifically, the invention provides the methods for sample preparation for proteomic analysis: the methods for the fragmentation of proteins into peptides with the specific cleavage rule (cleavage at amino-terminal or carboxyl-terminal of aspartic acid), which are suitable for the analysis by mass spectrometry apparatus. | 2008-12-25 |
20080318263 | METHOD OF IDENTIFYING CANCER BIOMARKERS AND CANCER PROGRESSION - An efficient method for identifying important cancer biomarkers and identifying progression of bladder cancer using pro-u-PA as a clinical tool is provided. Searching for biomarkers critical for bladder carcinoma diagnosis and prognosis, secreted proteomes of highly malignant U1 and pre-malignant U4 cell lines are first analyzed. Proteins in the cultured media of the U1 and U4 cell-lines were systematically examined by SDS-PAGE combined with MALDI-TOF mass spectrometry. Expression of pro-u-plasminogen activator (pro-u-PA) was confirmed by Western blot analysis and further evaluated. A statistically significant relationship between the low level and absence of pro-u-PA in urine with high stages and grades of the tumor samples was established. Constitutive expression of Ras dominant negative protein led to increased expression of pro-u-PA in cultured media, indicating the loss of pro-u-PA is associated with oncogenic transformation. The loss of pro-u-PA in urine has been identified as a marker of more advanced bladder carcinoma. | 2008-12-25 |
20080318264 | Biomarkers Associated With Age-Related Macular Degeneration - The invention relates to proteins associated with age-related macular degeneration (AMD). These proteins, which are present in blood, are expressed in individuals with AMD at either elevated or reduced levels compared to healthy individuals. The invention provides methods for diagnosing AMD. The invention provides methods for assessing the efficacy of treatment of AMD. The invention provides methods for monitoring the progression of AMD. | 2008-12-25 |
20080318265 | Measuring the Thickness of Organic Samples - This invention relates to a quality control method for improving histoprocessing, as well as a device for measuring the thickness of an organic tissue sample suited for use in the method. | 2008-12-25 |
20080318266 | FLUORESCENCE POLARIZATION INSTRUMENTS AND METHODS FOR DETECTION OF EXPOSURE TO BIOLOGICAL MATERIALS BY FLUORESCENCE POLARIZATION IMMUNOASSAY OF SALIVA, ORAL OR BODILY FLUIDS - The inventive subject matter relates to a method for detecting the presence of a biological substance of interest in a test sample of saliva or oral fluid, comprising combining said test sample with a fluorescence-labeled ligand to said biological substance and detecting a change in the fluorescence polarization of said test sample produced by binding of said fluorescence-labeled ligand to said biological substance. In one aspect of the inventive subject matter, said method comprises additional steps for comparing the fluorescence polarization of said test sample with the fluorescence polarization of a control solution. Also provided is a miniaturized, portable apparatus for measuring the fluorescence polarization of a liquid sample. | 2008-12-25 |
20080318267 | Methods and Compositions for Ultra-High Throughput Screening of Natural Products - The present invention provides cells having more than two drug resistance genes and at least two different resistance genes that have been recombined into the chromosome of a cell. It also teaches the processes for preparing cells by recombining two or more different drug resistance genes into the chromosome of a cell. The invention further shows a screening method using the cells of described herein that may be used to accomplish high throughput screening of, among other things, natural products and/or whole cells isolated from the environment. | 2008-12-25 |
20080318268 | Devices and Methods for the Selection of Agents with Efficacy Against Biofilm - This invention is a diagnostic plate that can be used to select antibiotic combinations with efficacy against microorganisms growing as a biofilm. The plate allows growth of biofilm on a plurality of projections, and the subsequent simultaneous challenge of biofilms on all projections of the plate to independent concentrations and combinations of anti-biofilm agents. Resistance of microorganisms to antibiotics is higher when they grow as a biofilm, as compared to when they grow in a planktonic state which is usually used to determine their level of antibiotic sensitivity. Growth of microorganisms that slough off the biofilm in the anti-biofilm agent challenge determines the Minimum Inhibitory Concentration (MIC) which relates to sensitivity of the microorganisms in a planktonic state. Growth of any surviving microorganisms from the biofilm in a subsequent recovery step determines the Minimal Biofilm Eradication Concentration (MBEC) which relates to the sensitivity of the microorganisms growing as a biofilm. Enumeration of the surviving microorganisms in the recovery step determines the Minimum Biocidal Concentration (MBC). | 2008-12-25 |
20080318269 | Devices and Methods for the Analysis of Biofilm - This invention is a diagnostic plate that can be used to select antibiotic combinations with efficacy against microorganisms growing as a biofilm. The plate allows growth of biofilm on a plurality of projections, and the subsequent simultaneous challenge of biofilms on all projections of the plate to independent concentrations and combinations of anti-biofilm agents. Resistance of microorganisms to antibiotics is higher when they grow as a biofilm, as compared to when they grow in a planktonic state which is usually used to determine their level of antibiotic sensitivity. Growth of microorganims that slough off the biofilm in the anti-biofilm agent challenge determines the Minimum Inhibitory Concentration (MIC) which relates to sensitivity of the microorganisms in a planktonic state. Growth of any surviving microorganims from the biofilm in a subsequent recovery step determines the Minimal Biofilm Eradication Concentration (MBEC) which relates to the sensitivity of the microorganisms growing as a biofilm. Enumeration of the surviving microorganims in the recovery step determines the Minimum Biocidal Concentration (MBC). | 2008-12-25 |
20080318270 | MASKING BACKGROUND FLUORESCENCE AND LUMINESCENCE IN THE OPTICAL ANALYSIS OF BIOMEDICAL ASSAYS - In a process for the quantitative optical analysis of fluorescently labelled biological cells | 2008-12-25 |
20080318271 | Subtilases - The present invention relates to novel JP170 like subtilases from wild-type bacteria, hybrids thereof and to methods of construction and production of these proteases. Further, the present invention relates to use of the claimed subtilases in detergents, such as a laundry or an automatic dishwashing detergent. | 2008-12-25 |
20080318272 | Gene Encoding Methylated Catechin Synthase - A gene encoding a methylated catechin synthase that can effectively synthesize methylated catechins having high antiallergic activity. | 2008-12-25 |
20080318273 | MUTANT PROTEINASE WITH REDUCED SELF-CLEAVAGE ACTIVITY AND METHOD OF PURIFICATION - The present invention provides a mutant 27 kDa NIa proteinase having reduced self-cleavage activity relative to the self-cleavage activity of its wild-type proteinase. The mutant has the same substrate cleavage activity as the wild-type proteinase but is more stable than the wild-type proteinase. The present invention also provides a method of obtaining large quantities of active 27 kDa NIa proteinase for use as a tool for purification of other proteins. | 2008-12-25 |
20080318274 | Methods and Compositions for Combinatorial-Based Production of Multivalent Recombinant Antigens - The present invention provides methods and compositions for rapidly producing multivalent recombinant vaccines using filamentous fungal heterokaryons. The present invention relies on the use of filamentous fungal heterokaryons that are generated from combinations of two or more parent strains into which recombinant DNA molecules encoding variants of antigens derived from pathogenic organisms have been introduced. The resulting vaccines are multivalent. | 2008-12-25 |
20080318275 | Hepatitis C virus asialoglycoproteins - Two Hepatitis C Virus envelope proteins (E1 and E2) are expressed without sialylation. Recombinant expression of these proteins in lower eukaryotes, or in mammalian cells in which terminal glycosylation is blocked, results in recombinant proteins which are more similar to native HCV glycoproteins. When isolated by GNA lectin affinity, the E1 and E2 proteins aggregate into virus-like particles. | 2008-12-25 |
20080318276 | Human Coagulation Factor VII Variants - The invention concerns novel coagulation factor VII variants, wherein the Phe residue in position 374 of SEQ ID NO 1 has been replaced by another amino acid residue which can be encoded by nucleic acid constructs and, optionally, wherein at least one other amino acid residue in the remaining positions in the protease domain has been replaced by another amino acid residue which can be encoded by nucleic acid constructs; with the proviso that the variant is not FVII(Ala305). | 2008-12-25 |
20080318277 | Expression of human milk proteins in transgenic plants - The invention is directed to seed and seed extract compositions containing levels of a human milk protein between 3-40% or higher of the total protein weight of the soluble protein extractable from the seed. Also disclosed is a method of producing the seed with high levels of extractable human milk protein. The method includes transforming a monocotyledonous plant with a chimeric gene having a protein-coding sequence encoding a protein normally present in human milk under the control of a seed maturation-specific promoter. The method may further includes a leader DNA sequence encoding a monocot seed-specific transit sequence capable to target a linked milk protein to a storage body. | 2008-12-25 |
20080318278 | Ammonia-Specific 5'-Xmp Aminase Mutant - Disclosed herein are ammonia-specific 5′-XMP aminase mutants and a method for preparing the same. A mutation is introduced into the active site of glutamine-dependent catalysis in 5′-XMP aminase. The resulting 5′-XMP aminase mutant is devoid of the glutamine-dependent activity and specifically reacts with external ammonia in converting 5′-XMP into 5′-GMP. Thus, the ammonia-specific 5′-XMP aminase mutant is stabler within cells compared to the wild type, and can be useful in the industrial conversion of 5′-XMP into 5′-GMP. | 2008-12-25 |
20080318279 | APPARATUS AND METHOD FOR PURIFICATION OF NUCLEIC ACIDS BY PHASE SEPARATION USING LASER AND BEADS - An apparatus and method for purification of nucleic acids of cells or viruses are provided. The nucleic acid purification apparatus includes: a cell lysis capillary having a sample inlet through which samples and magnetic beads are introduced; a vibrator attached to the capillary and mixing the samples and the magnetic beads in the capillary; a laser generator attached to the capillary and supplying a laser to the capillary; and a magnetic force generator attached to the capillary and fixing the magnetic beads to a capillary wall. According to the method and apparatus, PCR yield can be increased since PCR inhibitors can be readily removed by means of a phase separation in a capillary. The use of an electromagnet ensures the removal of the PCR inhibitors. In addition, since cell lysis and DNA purification process can be simultaneously performed, LOC steps can be reduced. | 2008-12-25 |
20080318280 | COVER FOR AN ARRAY OF REACTION VESSELS FOR ONE-STEP OPERATION MODUS - The present invention relates to means for covering one or more sample(s) that are suitable to avoid or minimize evaporation and/or condensation of any vaporizable substance that may be present in the sample(s) or reaction mixture(s), in particular evaporation of substance at the fringes of a vessel or an array of vessels or condensation of said substance on the lid of a reaction vessel or a plate/block containing the sample(s) and/or the means for covering. This is achieved by providing a device comprising, among others, a means for positioning a covering means and a means for guiding at least one lid of the covering means. | 2008-12-25 |
20080318281 | Thermostabillization of Dna Polymerase by Protein Folding Pathway from a Hyperthermophile Archaeon, Pyrococcus Furiosus - The present invention relates to maintaining the activity and stability of enzymes and biologically active proteins at increased temperatures by contacting same with a combination of isolated passive and active chaperones from a hyperthermopilic Archaeon, wherein the chaperones may include heat shock proteins, prefoldin and/or chaperonin proteins. | 2008-12-25 |
20080318282 | Nucleic acid amplification method - Provided is a simple and highly sensitive nucleic acid amplification method including hybridizing two types of oligonucleotide probes with a target gene and ligating the oligonucleotide probes with DNA ligase and amplifying the resultant single-stranded oligonucleotide in accordance with LAMP. | 2008-12-25 |
20080318283 | Fermentation Process for Continuous Plasmid Dna Production - A continuous process is described for the production of microbial plasmid DNA for use in biopharmaceutical and biotechnological applications. The process consists of: first growing microbial cells containing a plasmid at a reduced temperature in a continuous stage; followed by a second plasmid induction continuous culture stage with an increased temperature, with a residence time that allows accumulation of the plasmid product. A hold step at a reduced temperature after fermentation further increases the yield of plasmid product. The method enables production of a large quantity of highly purified plasmid DNA from a small bioreactor over time. | 2008-12-25 |
20080318284 | Processes for Producing a Fermentation Product - The present invention relates to processes for producing a fermentation product comprising (a) saccharifying starch-containing material below the initial gelatinization temperature in the presence of i) from 0.001-50 AGU/g DS, preferably 0.01 to 10 AGU/g DS alpha-glucosidase activity more than the native amount of endogenous alpha-glucosidase present in the starch-containing material, and ii) from 0 (zero) to 10 FAU-F/g DS of alpha-amylase activity, and (b) fermenting using a fermenting organism. The invention also relates to an enzymatic composition for use in a process of the invention. | 2008-12-25 |
20080318285 | METHOD OF PRODUCING MENINGOCOCCAL MENINGITIS VACCINE FOR NEISSERIA MENINGITIDIS SEROTYPES A, C, Y, and W-135 - Methods for producing quadrivalent meningococcal meningitis polysaccharide and conjugate vaccines for sero types A, C, Y and W-135 disclosed. | 2008-12-25 |
20080318286 | P1-35 Expression Units - The present invention relates to the use of nucleic acid sequences for regulating the transcription and expression of genes, the novel promoters and expression units themselves, methods for altering or causing the transcription rate and/or expression rate of genes, expression cassettes comprising the expression units, genetically modified microorganisms with altered or caused transcription rate and/or expression rate, and methods for preparing biosynthetic products by cultivating the genetically modified microorganisms. | 2008-12-25 |
20080318287 | Fermentative Production of Organic Compounds Using Substances Containing Dextrin - A process for the production of at least one organic compound having at least 3 C atoms or having at least 2 C atoms and at least 1N atom by means of fermentation, comprises the following steps:
| 2008-12-25 |
20080318288 | Enzymatic Reduction for Producing Optically Active Alcohols - A process for preparing optically active alkanols of the formula I | 2008-12-25 |
20080318289 | Fermentation Processes for the Preparation of Tacrolimus - The present invention relates to improved fermentation processes for the preparation of tacrolimus or a salt or derivative thereof by culturing a microorganism capable of producing tacrolimus or a salt or derivative thereof under submerged aerobic conditions with fed-batch processing at a high aeration rate. | 2008-12-25 |
20080318290 | NOVEL ALDOLASE AND PRODUCTION PROCESS OF SUBSTITUTED ALPHA-KETO ACIDS - 4-(Indol-3-ylmethyl)-4-hydroxy-2-oxoglutarate, which is useful as an intermediate in the synthesis of monatin, may be synthesized from indole pyruvic acid and pyruvic acid (and/or oxalacetic acid) by using a novel aldolase derived from the genus | 2008-12-25 |