51st week of 2013 patent applcation highlights part 45 |
Patent application number | Title | Published |
20130337496 | Method for Detecting a Plasmodium Infection - The invention relates to a method for detecting a | 2013-12-19 |
20130337497 | MAGNETIC FLOW CYTOMETRY FOR HIGH SAMPLE THROUGHPUT - In a measuring device, a production thereof, and a use thereof for magnetic flow cytometry, a microfluidic channel is disposed along an enrichment route such that a magnetically marked cell sample flowing through the microfluidic channel is aligned to magnetic guide strips, enriched by the magnetic field of a magnet at the floor of the channel, and guided past a sensor. The enrichment route is thereby implemented with the microfluidic channel on the packaging of the semiconductor chip carrying the sensor. This construction ensures a long enrichment route for high throughput of large sample volumes. | 2013-12-19 |
20130337498 | MICROORGANISM DETECTION SENSOR AND METHOD OF MANUFACTURING THE SAME - The present invention provides a sensor including a detection unit having a detection electrode and a polymer layer that is disposed on the detection electrode and includes a mold having a three-dimensional structure complementary to a steric structure of a microorganism to be detected. The sensor detects the microorganism based on a state of capturing the microorganism in the mold. The polymer layer is formed by a manufacturing method including: a polymerization step of polymerizing a monomer in the presence of the microorganism to be detected, to form the polymer layer having captured the microorganism on the detection electrode; a destruction step of partially destroying the microorganism captured in the polymer layer; and a peroxidation step of peroxidizing the polymer layer to release the microorganism from the polymer layer. | 2013-12-19 |
20130337499 | METHOD OF DETECTING COLIFORM BACTERIA FROM REFLECTED LIGHT - The present invention relates to a method of detecting coliform bacteria in water from reflected light, and also includes devices for the measurement, calculation and transmission of data relating to that method. | 2013-12-19 |
20130337500 | SYSTEM AND METHOD FOR ISOLATION OF CELLS - In accordance with an embodiment of the invention, there is provided a microfluidic device for isolating cells from a biological fluid. The device comprises an inlet receiving the biological fluid flowed into the device, and at least one array of a plurality of isolation wells receiving the biological fluid from the inlet. At least one isolation well of the plurality of isolation wells comprises a cell trap of a size and shape suitable to mechanically isolate a cell within the cell trap. The cell trap comprises at least one gap of a size and shape suitable to prevent passage of the cells to be isolated but to permit passage of other components of the biological fluid through the cell trap. | 2013-12-19 |
20130337501 | CELL ANALYZING APPARATUS AND CELL ANALYZING METHOD - A cell analyzing apparatus includes: a histogram acquirer which is configured to perform measurement of a number of nuclear stained cells, and which, by using a result of the measurement, is configured to acquire a histogram indicating a fluorescence intensity; and an analysis controller which is configured to apply frequency analysis on data of the histogram acquired by the histogram acquirer, and which is configured to determine existence/nonexistence of cancer cells based on a result of the frequency analysis. | 2013-12-19 |
20130337502 | ANALYSIS OF MICROBES FROM MICROCOLONIES BY MALDI MASS SPECTROMETRY - The invention relates to the cell disruption of microbes and the preparation of the microbe proteins for mass spectrometric analysis. The cells of microbes from microcolonies are disrupted by physical or chemical means directly on the nutrient medium. The released proteins are then transferred to sample supports by direct contact with their contact surfaces; electrophoresis can be used for assistance. Once the the proteins are firmly adsorbed on the contact surfaces, they can be washed with water in order to remove substances which interfere with the ionization process. For analysis by matrix-assisted laser desorption (MALDI), the proteins are prepared on the contact surfaces of the sample supports with matrix substances to form MALDI samples; the sample supports are then introduced into a MALDI mass spectrometer for the acquisition of the mass spectra. The microbes are identified by similarity comparisons between the mass spectra of the microbe proteins and similarly obtained reference spectra. | 2013-12-19 |
20130337503 | MUTANT PROTEINASE WITH REDUCED SELF-CLEAVAGE ACTIVITY AND METHOD OF PURIFICATION - The present invention provides a mutant 27 kDa NIa proteinase having reduced self-cleavage activity relative to the self-cleavage activity of its wild-type proteinase. The mutant has the same substrate cleavage activity as the wild-type proteinase but is more stable than the wild-type proteinase. The present invention also provides a method of obtaining large quantities of active 27 kDa NIa proteinase for use as a tool for purification of other proteins. | 2013-12-19 |
20130337504 | Methods and Compositions for Producing Active Vitamin K-Dependent Proteins - The present invention provides methods and compositions for the production of vitamin K dependent proteins. | 2013-12-19 |
20130337505 | MONOCLONAL ANTIBODY CAPABLE OF BINDING TO HEPARIN-BINDING EPIDERMAL GROWTH FACTOR-LIKE GROWTH FACTOR - Medicaments for treating diseases related to HB-EGF escalation are in demand. The present invention provides a method for producing a monoclonal antibody or an antibody fragment thereof which binds to a cell membrane-bound HB-EGF, a membrane type HB-EGF and a secretory HB-EGF. | 2013-12-19 |
20130337506 | CELL CULTURE MEDIUM AND PROCESS FOR PROTEIN EXPRESSION, SAID MEDIUM AND PROCESS COMPRISING A PAM INHIBITOR - The present invention is related to a cell culture medium for the expression of a protein, which medium comprises a PAM inhibitor, or a physiological equivalent thereof, and to a cell culture process for the expression of a protein, in which process a PAM inhibitor, or a physiological equivalent thereof, is used (FIG. | 2013-12-19 |
20130337507 | Xylanases, Nucleic Acids Encoding Them and Methods for Making and Using Them - The invention relates to xylanases and to polynucleotides encoding the xylanases. In addition, methods of designing new xylanases and methods of use thereof are also provided. The xylanases have increased activity and stability at increased pH and temperature. | 2013-12-19 |
20130337508 | BETA-GLUCOSIDASE ENHANCED FILAMENTOUS FUNGAL WHOLE CELLULASE COMPOSTIONS AND METHODS OF USE - The present disclosure provides beta-glucosidase enhanced filamentous fungal whole cellulase compositions. Also provided are methods of hydrolyzing a cellulosic material with beta-glucosidase enhanced whole cellulase compositions. The present disclosure further provides methods of decreasing the amount of a whole cellulase required to hydrolyze a cellulosic material by adding an effective amount beta-glucosidase. | 2013-12-19 |
20130337509 | Processes for Enzymatic Refining of Pretreated Cellulosic Material for Saccharification - The present invention relates to processes for processes for enzymatic refining of a pretreated cellulosic material for saccharification. | 2013-12-19 |
20130337510 | Methods and compositions for degrading cellulosic material - The present invention relates to enzyme compositions comprising a polypeptide having cellobiohydrolase II activity, a polypeptide having xylanase activity, and one or more cellulolytic proteins and their use in the degradation or conversion of cellulosic material. | 2013-12-19 |
20130337511 | Method for Producing Pyrroloquinoline Quinone Using a Bacterium of the Genus Methylobacterium or Hyphomicrobium - The present invention provides a method for producing PQQ using a bacterium belonging to the genera | 2013-12-19 |
20130337512 | Amidase and Use Thereof for Producing 3-Aminocarboxylic Acid Esters - Process for producing optically active 3-aminocarboxylic acid ester compounds of general Formula I, and the ammonium salts thereof, | 2013-12-19 |
20130337513 | INTEGRATED PROCESSES FOR BIOCONVERTING SYNGAS TO OXYGENATED ORGANIC COMPOUND WITH SULFUR SUPPLY - Integrated processes are provided for the bioconversion of syngas to oxygenated organic compound with the ability to recycle sulfur nutrient and generate sulfur nutrient to the syngas fermentation in a safe and cost-effective manner. In preferred aspects of the invention, an acidogenic digestion is used to provide a biogas containing hydrogen sulfide, and then a methanogenic fermentation can follow to provide a methane-containing biogas that has a low hydrogen sulfide concentration. | 2013-12-19 |
20130337514 | PRODUCTION OF POLYUNSATURATED FATTY ACIDS BY COEXPRESSION OF ACYL-CoA:LYSOPHOSPHATIDYLCHOLINE ACYLTRANSFERASES AND PHOSPHOLIPID:DIACYLGLYCEROL ACYLTRANSFERASES - Acyl-CoA:lysophosphatidylcholine acyltransferase [“LPCAT”] having the ability to convert acyl-CoA+1-acyl-sn-glycero-3-phosphocholine to CoA+1,2-diacyl-sn-glycero-3-phosphocholine (EC 2.3.1.23) is disclosed herein to be over-expressed along with the over-expression of phospholipid:diacylglycerol acyltransferase [“PDAT”] having the ability to transfer a fatty acyl group from the sn-2 position of a phospholipid (e.g., phosphatidylcholine) to the sn-3 position of 1,2-diacylglycerol [E.C.2.3.1.158], thus resulting in a lysophospholipid and TAG. Co-expression of these enzymes in a recombinant microbial host cell resulted in increased production of long chain polyunsaturated fatty acids [“PUFAs”]. | 2013-12-19 |
20130337515 | PROCESS FOR PRODUCTION OF LOW SATURATE OILS - Provided here is an enzymatic process for production of low saturate oil, in one embodiment, low palmitic oils from triacylglycerol sources. The enzymes used in the processes herein are saturase enzymes, including palmitase enzymes. The oils produced by the processes herein are used in food products. | 2013-12-19 |
20130337516 | POLYHYDROXYALKANOATE PRODUCTION METHOD - Provided are processes for the production and high efficiency processing of polyhydroxyalkanoates (PHA) from carbon sources comprising carbon-containing gases or materials. | 2013-12-19 |
20130337517 | ENHANCED EFFICIENCY ETHANOL AND SUGAR CONVERSION PROCESSES - Overlay processes are disclosed for making ethanol that not only increase ethanol conversion but do so in a cost effective manner with a reduction in energy requirements per unit of ethanol production. The processes can provide, if desired, higher organic compound as a co-product with ethanol. | 2013-12-19 |
20130337518 | NOVEL BIOCATALYST COMPOSITIONS AND PROCESSES FOR USE - The microorganism-containing biocatalysts disclosed have a large population of the microorganisms irreversibly retained in the interior of the biocatalysts. The biocatalysts possess a surprisingly stable population of microorganisms and have an essential absence of debris generation from metabolic activity of the microorganisms. The biocatalysts are composed of highly hydrophilic polymer and have an internal, open, porous structure that promotes community phenotypic changes. | 2013-12-19 |
20130337519 | METHOD OF PRODUCING SUCCINIC ACID AND OTHER CHEMICALS USING SUCROSE-CONTAINING FEEDSTOCK - This invention relates to the production of chemicals by fermentation with a microorganism in which the fermentation medium contains the sugar sucrose. As a specific example, succinic acid is produced from a sucrose-containing renewable feedstock through fermentation using a biocatalyst. Examples of such a biocatalyst include microorganisms that have been enhanced in their ability to utilize sucrose as a carbon and energy source. The biocatalysts of the present invention are derived from the genetic manipulation of parental strains that were originally constructed with the goal to produce one or more chemicals (for example succinic acid and/or a salt of succinic acid) at a commercial scale using feedstocks other than sucrose. The genetic manipulations of the present invention involve the introduction of exogenous genes involved in the transport and metabolism of sucrose into the parental strains. The genes involved in the transport and metabolism of sucrose can also be introduced into a microorganism prior to developing the organism to produce a particular chemical. The genes involved in the transport and metabolism of sucrose can also be used to augment or improve the sucrose transport and metabolism by strains already known to have some ability for sucrose utilization in biological fermentation. | 2013-12-19 |
20130337520 | CONTAMINANT CONTROL IN ZYMOMONAS FERMENTATION USING HOP ACIDS - Contamination was controlled in fermentations using | 2013-12-19 |
20130337521 | METHODS AND SYSTEMS FOR REDUCING THE LEVEL OF ONE OR MORE IMPURITIES THAT ARE PRESENT IN A PRETREATED CELLULOSIC MATERIAL AND/OR DISTILLATE - The present invention relates to methods and systems for remediating one or more impurities (e.g., diacetyl) that are present in manufacturing an alcohol (e.g., ethanol) from cellulosic biomass. The methods and systems include reacting the one or more impurities with at least one treatment compound (e.g., an oxidizing agent, an alkali compound, or a mixture thereof) to form a reaction product that can be separated from the alcohol. | 2013-12-19 |
20130337522 | CONTAMINANT CONTROL IN ZYMOMONAS FERMENTATION USING VIRGINIAMYCIN - Contamination was controlled in fermentations using | 2013-12-19 |
20130337523 | Biomass Treatment Process - A process for the treatment of biomass is provided. The process comprises forming a biomass slurry by mixing biomass with a working fluid, and inducing the biomass slurry to flow through an inlet into a passage. A high velocity transport fluid is injected into the slurry through a nozzle communicating with the passage. The injection of the high velocity transport fluid applies a shear force to the slurry such that the working fluid is atomised and forms a vapour and droplet flow regime, an at least partial vacuum is formed within the passage downstream of the nozzle, and a condensation shock wave is generated within the passage downstream of the nozzle and vacuum by condensation of the transport fluid. An apparatus for treating biomass using the aforementioned process is also provided. | 2013-12-19 |
20130337524 | SYSTEMS AND METHODS FOR COLLECTING BIOMASS - A system for collecting biomass for the production of ethanol is disclosed. Also disclosed is a method for collecting biomass. The method comprising: harvesting biomass with a combine, wherein a first portion of the biomass is substantially forced against the ground and a second portion of the biomass passes through the combine and forming bales comprising the second portion of the biomass. According to an aspect, the bales comprise a majority of the second portion of the biomass and a small part of the first portion of the biomass. | 2013-12-19 |
20130337525 | Method of Producing Ethanol - A method of producing ethanol by adding a cellulosic raw material treatment liquid to a sugar-containing liquid and then performing ethanol fermentation, in which the sugar-containing liquid is one or more types selected from the group consisting of extracted juice of crops, molasses, and enzyme-treated products of cereals containing a water-soluble saccharide, and the cellulosic raw material treatment liquid is either a sugar solution derived from cellulosic raw materials obtained by saccharification of the cellulosic raw materials or a fermentation broth derived from the cellulosic raw materials obtained by ethanol fermentation of the sugar solution derived from the cellulosic raw materials. | 2013-12-19 |
20130337526 | Method of Producing Ethanol - A method of producing ethanol from cellulosic raw materials, including steps of: saccharification of the cellulosic raw materials after adding a fermentation broth derived from a sugar-containing liquid, and ethanol-fermenting a sugar solution obtained in the above saccharifying step, in which the fermentation broth derived from the sugar-containing liquid is obtained by ethanol fermentation of one or more types of sugar-containing liquid selected from the group consisting of extracted juice of crops, molasses, and an enzyme-treated product of cereals containing a water-soluble saccharide. | 2013-12-19 |
20130337527 | INTEGRATED SYSTEM AND PROCESS FOR BIOPRODUCT PRODUCTION - Processes and systems for production of bioproducts such as biofuels are provided. The bioproduct production processes and systems utilize pretreatment of a carbohydrate-containing feedstock to produce soluble sugar molecules and continuous conversion of the pretreated feedstock to a bioproduct by an immobilized fermenting microorganism. | 2013-12-19 |
20130337528 | COMPOSITIONS FOR SEPARATION METHODS - This invention relates generally to the fields of separation and conversion technologies, and more particularly to materials for use in tangential-flow filtration techniques. The tangential-flow materials are useful in a wide range of separation and conversion processes, including those reliant on reverse osmosis, microfiltration, ultrafiltration, or nanofiltration semipermeable filtration membranes, and provide efficient methods for purifying or producing various target substances, including biopolymer particles for use in tangential-flow filtration. | 2013-12-19 |
20130337529 | Cell Culture - A method for determining the effect of a plurality of culture conditions on a cell, comprising the steps of: a) providing a first set of groups of cell units each comprising one or more cells, and exposing said groups to desired culture conditions; (b) pooling two or more of said groups to form at least one second pool; (c) subdividing the second pool to create a further set of groups of cell units; (d) exposing said further groups to desired culture conditions; (e) optionally, repeating steps (b)-(d) iteratively as required; and (f) optionally assessing the effect on a given cell unit of the culture conditions to which it has been exposed. | 2013-12-19 |
20130337530 | Chemical Additives to Make Polymeric Materials Biodegradable - The present invention is a new additive material that is physically blended with polymeric material to create at least a partially biodegradable product. | 2013-12-19 |
20130337531 | RECOVERY OF INSOLUBLE ENZYME FROM FERMENTATION BROTH AND FORMULATION OF INSOLUBLE ENZYME - Methods are provided for recovery and formulation of insoluble enzymes from a microbial fermentation broth, without removal of microbial cells or cell debris. Granular and liquid formulations comprising insoluble enzymes are also provided. | 2013-12-19 |
20130337532 | THERAPEUTIC POLYPEPTIDES WITH INCREASED IN VIVO RECOVERY - The present invention relates to the field of modified therapeutic polypeptides with increased in vivo recovery compared to their non-modified parent polypeptide. For example, the invention relates to fusions of therapeutic polypeptides with recovery enhancing polypeptides connected directly or optionally connected by a linker peptide. | 2013-12-19 |
20130337533 | Compositions for Diagnosis and Therapy of Diseases Associated with Aberrant Expression of Futrins (R-Spondins) and/or Wnt - The present invention relates to a composition useful for the diagnosis of diseases associated with aberrant expression of the genes encoding the secreted proteins Futrin 1, 2, 3 and/or 4(=R-Spondin 2, 3, 1 and 4, respectively), e.g. in connection with tumors or diseases of the muscle, kidneys or bones. The present invention also relates to a pharmaceutical composition containing a compound which is capable of modifying (a) the expression of the gene encoding Futrin 1, 2, 3 and/or 4 or (b) the activity of the Futrin 1, 2, 3 and/or 4 protein. | 2013-12-19 |
20130337534 | Acryloyloxyethylphosphorylcholine Containing Polymer Conjugates And Their Preparation - The present invention relates to polymeric reagents and conjugates thereof, methods for synthesizing the polymeric reagents and conjugates, pharmaceutical compositions comprising the conjugates and methods of using the polymer conjugates including therapeutic methods where conjugates are administered to patients. | 2013-12-19 |
20130337535 | Control of Cyanate in Aqueous Urea Solutions by Non-1,2-Ethylene Diamine Like Compounds for the Protection of Protein/Peptide Carbamylation - Embodiments of the present invention generally relate to processing of peptides in urea solutions and substantial prevention of carbamylation of the peptide. | 2013-12-19 |
20130337536 | Labeling Reagents and Methods of Their Use - The present disclosure is directed to a reactive ester agent capable of conjugating a reporter molecule to a carrier molecule or solid support. The reactive ester agent has the general formula: | 2013-12-19 |
20130337537 | COAGULATION FACTOR-TARGETING TO TLT-1 ON ACTIVATED PLATELETS - The current invention relates to: procoagulant proteins which may, for example, be fusion proteins or chemical conjugates; methods of producing said procoagulant proteins; polynucleotides that encode said fusion proteins and cells that expresses them. Furthermore, the current invention relates to procoagulant proteins for use as a medicament. Individuals that have a coagulopathy, such as haemophilia A and B with or without inhibitors, may be treated with the procoagulant proteins of the current invention. | 2013-12-19 |
20130337538 | MUTANT ACYL-CoA:LYSOPHOSPHATIDYLCHOLINE ACYLTRANSFERASES - Mutant acyl-CoA:lysophosphatidylcholine acyltransferases [“LPCATs”] having the ability to convert acyl-CoA+1-acyl-sn-glycero-3-phosphocholine to CoA+1,2-diacyl-sn-glycero-3-phosphocholine (EC 2.3.1.23) are disclosed herein. Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding mutant LPCATs, along with a method of making long chain polyunsaturated fatty acids [“PUFAs”] using these mutant LPCATs in oleaginous yeast, are also disclosed. | 2013-12-19 |
20130337539 | COVALENT TETHERING OF FUNCTIONAL GROUPS TO PROTEINS AND SUBSTRATES THEREFOR - A mutant hydrolase optionally fused to a protein of interest is provided. The mutant hydrolase is capable of forming a bond with a substrate for the corresponding nonmutant (wild-type) hydrolase which is more stable than the bond formed between the wild-type hydrolase and the substrate and has at least two amino acid substitutions relative to the wild-type hydrolase. Substrates for hydrolases comprising one or more functional groups are also provided, as well as methods of using the mutant hydrolase and the substrates of the invention. Also provided is a fusion protein capable of forming a stable bond with a substrate and cells which express the fusion protein. | 2013-12-19 |
20130337540 | Novel Class of Therapeutic Protein Based Molecules - The present invention provides new compositions and methods for preventing and treating pathogen infection. In particular, the present invention provides compounds having an anchoring domain that anchors the compound to the surface of a target cell, and a therapeutic domain that can act extracellularly to prevent infection of a target cell by a pathogen, such as a virus. The present invention also comprises therapeutic compositions having sialidase activity, including protein-based compounds having sialidase catalytic domains. Compounds of the invention can be used for treating or preventing pathogen infection, and for treating and reducing allergic and inflammatory responses. The invention also provides compositions and methods for enhancing transduction of target cells by recombinant viruses. Such compositions and methods can be used in gene therapy. | 2013-12-19 |
20130337541 | THERMOSTABLE CHITOSANASE - The present application concerns a thermostable chitosanase, originally identified in | 2013-12-19 |
20130337542 | Cellulase Enzyme Mixtures For Depilling and Uses Thereof - The present invention relates to a depilling composition comprising an enzyme mixture that comprises a Family 45 cellulase enzyme component and one or more additional cellulase enzyme components selected from a Family 5 cellulase, a Family 6 cellulase or a combination thereof. The enzyme mixture may be characterized in that the Family 45 and the Family 5 cellulase enzyme components or the Family 45 and the Family 6 cellulase enzyme components are present at a weight ratio that exhibits synergy in an assay that measures specific depilling activity. The enzyme mixture may be secreted by a genetically modified microbe overexpressing theforegoing cellulase enzyme components. Also provided is a process for depilling that comprises a step of contacting cellulose-containing goods with the depilling composition. | 2013-12-19 |
20130337543 | AAV4 VECTOR AND USES THEREOF - The present invention provides an adeno-associated virus 4 (AAV4) virus and vectors and particles derived therefrom. In addition, the present invention provides methods of delivering a nucleic acid to a cell using the AAV4 vectors and particles. | 2013-12-19 |
20130337544 | METHODS AND COMPOSITION FOR THE IDENTIFICATION OF ANTIBIOTICS THAT ARE NOT SUSCEPTIBLE TO ANTIBIOTIC RESISTANCE - Compositions are provided to identify functional mutant ribosomes that may be used as drug targets. The compositions allow isolation and analysis of mutations that would normally be lethal and allow direct selection of rRNA mutants with predetermined levels of ribosome function. The compositions of the present invention may be used to identify antibiotics to treat a large number of human pathogens through the use of genetically engineered rRNA genes from a variety of species. The invention further provides novel plasmid constructs to be used in the methods of the invention. | 2013-12-19 |
20130337545 | MINICELL BASED DELIVERY OF BIOLOGICALLY ACTIVE COMPOUNDS - Minicells are used to deliver biologically active compounds including radioisotopes, polypeptides, nucleic acids, small molecules, drug molecules, and chemotherapeutic agents. In some cases, the minicell displays ligands or binding moieties that target the minicell to a desired host cell. | 2013-12-19 |
20130337546 | Centrifugation and Filtration Methods for Concentrating Microorganisms - A process for concentrating microorganism-containing suspensions comprising (a) centrifuging a microorganism-containing suspension to provide a first microorganism-containing concentrate and a supernatant liquid; (b) filtering said first microorganism-containing concentrate, to provide a permeate and a second microorganism-containing concentrate. | 2013-12-19 |
20130337547 | THERMOSTABLE BIOCATALYST COMBINATION FOR NUCLEOSIDE SYNTHESIS - A recombinant expression vector comprising: a) the sequence encoding a purine nucleoside phosphorylase (PNPase, E. C. 2.4.2.1), b) the sequence encoding a uridine phosphorylase (UPase, E. C. 2.4.2.3), c) or both; each of the sequences operably linked to one or more control sequences that direct the production of said phosphorylases in a suitable expression host; said sequences originating from the Archaea Thermoprotei class, characterized in that the PNPase is from | 2013-12-19 |
20130337548 | Rotating Bioreactor - A bioreactor, including at least one rotating drum, a substrate on the drum whereon a biofilm may grow, a rotational device rotating the drum and substrate, and a harvesting device. | 2013-12-19 |
20130337549 | MATERIALS AND METHODS FOR NERVE GRAFTING - The subject invention pertains to compositions and methods for promoting repair of damaged nerve tissue using nerve grafts and preparation of nerve grafts. The compositions and methods of the subject invention can be employed to restore the continuity of nerve interrupted by disease, traumatic events or surgical procedures. Compositions of the subject invention comprise one or more chondroitin sulfate proteoglycan (CSPG)-degrading enzymes that promote axonal penetration into damaged nerve tissue and nerve graft. The invention also concerns methods for promoting repair of damaged nerve tissue using the present compositions and nerve tissue treated according to such methods. The invention also includes storage solutions for nerve tissue. | 2013-12-19 |
20130337550 | PROCESS FOR THE EXTRACTION OF LIPIDS - The present invention provides a process for the extraction of lipids from microbial lipid-containing feedstock, comprising the steps of (a) subjecting the microbial lipid-containing feedstock to a treatment to release the lipids thereby producing a mixture; (b) subjecting the mixture obtained in (a) to a filtration in the presence of a first extraction solvent on a filter, wherein organic matter soluble in an extraction solvent and an aqueous mixture are removed as filtrate from a retentate comprising non-soluble matter; (c) separating the filtrate obtained from the filter into an organic and aqueous phase; and (d) subjecting the organic phase to a distillation treatment to separate solvent and an organic residue comprising extracted lipids. | 2013-12-19 |
20130337551 | APPARATUS AND METHODS FOR CELL ISOLATION - A unitary apparatus for isolating cells from adipose tissue including a lipid separation processor with a dispersing head equipped with a plurality of ports and a digestion chamber for dissociation of the constituent cells disposed in adipose tissue. The lipid separating apparatus is useful for the separation of lipids and adipocytes from a mixed cell population. A cell seeding chamber may be attached to the cell isolation apparatus. The components of the apparatus may be packaged in modular kit form. | 2013-12-19 |
20130337552 | FERMENTATION APPARATUS THAT USES BIOMASS AS FEEDSTOCK - There is provided an apparatus for treating a biomass feedstock at a high temperature, including: a cooling means for cooling a biomass liquid treated at a high temperature; an enzymatic saccharification tank for subjecting a cooled treated liquid to saccharification with an enzyme; a solid-liquid separation apparatus for removing water-slightly soluble fermentation inhibitory substances contained in the saccharide solution taken out from the enzymatic saccharification tank and a foreign substance removing unit provided with a microfiltlation (MF) membrane | 2013-12-19 |
20130337553 | TRANSPLANTATION GUIDE AND TRANSPLANTATION DEVICE - The present invention provides a transplantation guide which is formed into a bottomed cylinder having a base material that allows communication of a culture fluid, wherein:
| 2013-12-19 |
20130337554 | CULTURE DEVICE - A culture device includes a deformable cell-culture unit that includes a culture membrane and a surrounding wall extending upwardly from a periphery of the culture membrane, and a deformable engaging unit that is connected to the surrounding wall of the deformable cell-culture unit, that is adapted to engage a stretching device, and that has a hardness larger than that of the cell-culture unit. | 2013-12-19 |
20130337555 | Cassette For Sample Preparation - Apparatuses for preparing a sample are disclosed herein. The apparatuses include a chamber, a first valve at least partially disposed in the first chamber, a second valve at least partially disposed in the first chamber, and a pump comprising an actuator and nozzle. | 2013-12-19 |
20130337556 | METHODS FOR DELIVERING GENES - Methods of delivering transgenes to target cells using plasmids comprising viral inverted terminal repeat (ITR) sequences are described. Such plasmids are capable of directing sustained transgene expression in target cells in rats provided that at least one adeno-associated virus (AAV) ITR sequence is present in the plasmid, regardless of whether that ITR is located upstream or downstream of the transgene. In a particular embodiment, plasmids comprising one or more AAV ITR sequence and an IL-10 transgene are shown to be effective in sustained reversal of pain in an animal model of neuropathic pain. | 2013-12-19 |
20130337557 | Use of cell-permeable peptide inhibitors of the JNK signal transduction pathway for the treatment of chronic or non-chronic inflammatory eye diseases - The present invention refers to the use of protein kinase inhibitors and more specifically to the use of inhibitors of the protein kinase c-Jun amino terminal kinase, JNK inhibitor (poly-)peptides, chimeric peptides, or of nucleic acids encoding same as well as pharmaceutical compositions containing same, for the treatment of non-chronic or chronic inflammatory eye diseases, such as inflammatory diseases of the blephara, conjunctiva, cornea, sclera, the vitreous body, uvea, ciliary body, choroid, orbital bone, lacrimal gland, or iris, in particular wherein the inflammatory disease is selected from hordeolum, chalazion, conjunktivitis, keratitis, scleritis, episcleritis, endophthalmitis, panophtalmitis, irititis, uveitis, cyclitis, chorioiditis, orbital phlegmon, and myositis of the eye muscle etc. | 2013-12-19 |
20130337558 | ADHERENT CELLS FROM PLACENTA TISSUE AND USE THEREOF IN THERAPY - A method of culturing adherent cells from a placenta or adipose tissue is disclosed. The method comprises culturing the adherent cells from the placenta or adipose tissue under 3 dimensional (3D) culturing conditions which allow cell expansion, the conditions comprising perfusion. | 2013-12-19 |
20130337559 | HUMANIZED ANTI-TAG 72 CC49 FOR DIAGNOSIS AND THERAPY OF HUMAN TUMORS - The present disclosure provides humanized CC49 monoclonal antibodies that bind TAG-72 with high binding affinity and that are minimally immunogenic. In one embodiment, a humanized CC49 antibody includes a non-conservative amino acid substitution in a light chain complementarity determining region 3 of the CC49 antibody. In a further embodiment, the humanized CC49 antibody includes a non-conservative substitution of a first residue in a light chain complementarity determining region 3 and a substitution of a second residue in a complementarity determining region of the humanized CC49 antibody. In several of the embodiments, methods are disclosed for the use of a humanized CC49 antibody. | 2013-12-19 |
20130337560 | Methods of Decellularizing Bone - The invention provides methods for decellularizing bone, e.g., human bone. | 2013-12-19 |
20130337561 | Differentiation and Enrichment of Islet-Like Cells from Human Pluripotent Stem Cells - Methods for differentiating human pluripotent stem cells into islet-like cells are provided. In certain embodiments, the methods utilize sequential culturing of the human pluripotent stem cells with certain factors to produce islet-like cells. In certain embodiments, the population of cells produced by the methods is further enriched for islet-like cells. | 2013-12-19 |
20130337562 | METHODS FOR CULTURING UNDIFFERENTIATED CELLS USING SUSTAINED RELEASE COMPOSITIONS - Methods for culturing undifferentiated mammalian cells, such as stem and progenitor cells, are provided. The methods involve incubating the cell in the presence of a sustained release composition containing at least one growth factor, wherein the sustained release composition continuously releases the growth factor(s), and wherein the presence of the sustained level of growth factor maintains the cell in an undifferentiated state. | 2013-12-19 |
20130337563 | ISOLATION, CULTIVATION AND USES OF STEM/PROGENITOR CELLS - The present invention relates to a method for isolating stem/progenitor cells from the amniotic membrane of umbilical cord, wherein the method comprises separating the amniotic membrane from the other components of the umbilical cord in vitro, culturing the amniotic membrane tissue under conditions allowing cell proliferation, and isolating the stem/progenitor cells from the tissue cultures. The isolated stem cell cells can have embryonic stem cell-like properties and can be used for various therapeutic purposes. In one embodiment, the invention relates to the isolation and cultivation of stem cells such as epithelial and/or mesenchymal stem/progenitor cells under conditions allowing the cells to undergo mitotic expansion. Furthermore, the invention is directed to a method for the differentiation of the isolated stem/progenitor cells into epithelial and/or mesenchymal cells. | 2013-12-19 |
20130337564 | Treatment of Pluripotent Cells - The present invention is directed to methods to treat pluripotent cells, whereby the pluripotent cells can be efficiently expanded in culture and differentiated by treating the pluripotent cells with an inhibitor of GSK-3B enzyme activity. | 2013-12-19 |
20130337565 | Method and Apparatus for Patterning Cells - The present invention is directed to tissue engineering and, more particularly, to devices and methods that are used to pattern or deposit cells to simulate a tissue type in two dimensions or in three dimensions or a cell migration device, a materials testing device for cell proliferation, migration or cell seeder for the Bioflex® flexible bottom culture plates or comparable culture plates. The present invention operates by providing negative pressure to create multiple troughs or indentations for cells to attach and grow on or in the Bioflex® flexible bottom culture plates. The present invention is also directed to a device and method for simulating a tissue wound using the above devices. | 2013-12-19 |
20130337566 | RESPONSIVE CELL CULTURE HYDROGEL - The present invention provides devices, compositions and methods for maintaining conditions in a cell culture and for measurement of conditions in the cell culture. In particular, the invention provides hydrogel materials, apparatus and methods for several non-invasive techniques of maintaining optimal or near-optimal nutrient and pH levels in cell cultures. | 2013-12-19 |
20130337567 | NANOWIRE FIELD-EFFECT TRANSISTOR BIOSENSOR WITH IMPROVED SENSITIVITY - The present invention is directed to a multiwire nanowire field effect transistor (nwFET) device for the measurement. The device includes a sensing nanowire having a first end and a second end and a nanowire FET having a first end and a second end, wherein the first end of the sensing nanowire is connected to the nanowire FET to form a node. Additionally, the first end of the nanowire FET is connected to a source electrode, the second end of the nanowire FET is connected to a drain electrode, and the second end of the sensing nanowire is connected to a base electrode. The sensing nanowire is derivatized with a plurality of immobilized capture probes that are specific for a target(s) of interest. The device is used to detect biomolecules or to detect the change in the ionic environment of a sample. In a further embodiment, the sensing nanowire is derivatized with amino, carboxyl or hydroxyl groups. Upon a change in ionic environment, or binding of a molecule to the sensing nanowire, the sensing nanowire current (I | 2013-12-19 |
20130337568 | METHOD TO MEASURE SURFACTANT IN FLUID - The invention is directed towards methods and compositions for identifying the presence of surfactants in water. The invention is quite superior over the prior art because it can form a colorful complex in half the time, avoid the need for difficult separation steps, use a safer solvent and avoid the formation of messy foam. The invention involves adding to the water a cobalt thiocyanate reagent, pre-prepared from a cobalt salt and a thiocyanate salt, which forms a colorful complex with the surfactant. Chloroform is then added to the water. The cobalt reagent causes the virtually all of the surfactant to form a colored complex which rapidly migrates into the chloroform and prevents the surfactant from foaming. Once in the chloroform, a UV-vis spectrometer can easily and precisely identify the type and amount of surfactant that was in the water. | 2013-12-19 |
20130337569 | SERS Nanotag Assays - Methods and systems for the use of Surface Enhanced Raman Scattering nanotags (SERS nanotags) to create homogeneous (no-wash), heterogeneous or sequence detection assay platforms. In certain embodiments the SERS nanotags are used in combination with magnetic particles. Multiplexed assay platforms are also disclosed. In certain embodiments, the assay is useful for clinical proteomics. Assay platforms suitable for use within a biological matrix, for example within whole blood or serum are also disclosed. The assay formats described herein may be used to detect any analyte of interest including but not limited to the detection of cells, viruses, bacteria, proteins, DNA, RNA, or small molecules in any type of biological (animal or plant kingdom) or environmental samples including but not limited to whole blood or serum, occult samples, urine, feces, air, drinking water, phage, any organism, multicellular clumps of cells, for example, cancer tissue homogenate. | 2013-12-19 |
20130337570 | METHOD FOR QUANTITATIVE ANALYSIS OF SUGARS, SUGAR ALCOHOLS AND RELATED DEHYDRATION PRODUCTS - An improved method is provided for the quantitative analysis of mixtures including various sugars, sugar alcohols and related dehydration products, whereby these are enabled to be effectively and accurately quantitated through gas chromatography, for example, by their derivatization with a carboxylic acid, carboxylic acid anhydride or halide in the presence of a metal triflate catalyst. The method can be carried out at essentially room temperature conditions, with a sufficiently rapid and complete derivatization, even in the presence of substantial amounts of water, that the materials to be quantitated do not substantially break down or degrade and substantially completely accounted for in a derivatized form. | 2013-12-19 |
20130337571 | BIOLOGICAL SAMPLE MEASURING DEVICE AND METHOD FOR MEASURING BIOLOGICAL SAMPLE USING SAME - With this biological sample measuring device, the determination section performs measurement at specific intervals in a first measurement period from the start of measurement until a first time, and performs measurement at specific intervals in a second measurement period that comes after the first measurement period, calculates the difference between the measurement values in corresponding specific periods, and finds a plurality of first difference determination values, on the basis of a plurality of current values measured in the first measurement period and a plurality of current values measured in the second measurement period, finds a second difference determination value by finding the difference at specific intervals in the plurality of first difference determination values, and determines whether or not a reagent movement error and/or exposure error of the biological sample measurement sensor has occurred, on the basis of the first and second difference determination values. | 2013-12-19 |
20130337572 | METHOD AND APPARATUS FOR MEASURING BROMATE ION - A method for measuring bromate ion includes: a first step of introducing a test water sample to an anion exchanger that selectively absorbs bromate ions; a second step of introducing, to the anion exchanger, a hydrochloric acid solution containing a fluorescent substance, a fluorescence intensity of which is changed by the coexistence of bromate ions; a third step of measuring the fluorescence intensity of the fluorescent substance contained in the hydrochloric acid solution discharged from the anion exchanger; and a fourth step of using a calibration curve, which shows a relationship between the fluorescence intensity of the fluorescent substance and the concentration of the bromate ions, to calculate the concentration of the bromate ions that corresponds to the measured fluorescence intensity. | 2013-12-19 |
20130337573 | METHOD FOR EVALUATING CHEMICAL STABILITY OF POLYCHLOROPRENE LATEX - Provided is a method for evaluating of the chemical stability of a polychloroprene latex that permits evaluation of the chemical stability of polychloroprene at high accuracy. | 2013-12-19 |
20130337574 | METHOD FOR DETERMINING A SHAPE CORRECTION VALUE F FOR LABORATORY LIQUID-ANALYSIS CUVETTES - A method for determining a shape correction value F for a laboratory liquid-analysis cuvette comprising a cuvette body with a circular cross-section for a photometric liquid analysis includes optically measuring an inside diameter d | 2013-12-19 |
20130337575 | AUTOMATED AND ACCURATE DROP DELAY FOR FLOW CYTOMETRY - Disclosed is an automated method and apparatus for automatically setting a drop delay period by detecting calibration particles in a waste stream. The drop delay is incremented over a series of drop delays and the number of calibration particles in the waste stream is detected for each drop delay. The drop delay is selected which has the least number of calibration particles in the waste stream. | 2013-12-19 |
20130337576 | MICROFLUIDIC SYSTEM, CARTRIDGE AND METHOD FOR PREPARING SAMPLE - A microfluidic system for preparing a sample containing an analyte of interest is provided. The microfluidic system includes a microfluidic cartridge and a magnetic element. The microfluidic cartridge includes a number of reservoirs, an immobilizer, a number of microfluidic flow channels and a number of microvalves. The microfluidic channels are coupled with the reservoirs and the immobilizer. The microvalves are positioned along the microfluidic flow channels. The magnetic element is positioned with respect to the immobilizer. The magnetic element is configured to generate a magnetic field to magnetically immobilize the analyte of interest in the immobilizer. The immobilizer is configured to flow one or more reagents therethrough to react with the analyte of interest. | 2013-12-19 |
20130337577 | Extraction Pipette - A solid-phase extraction pipette ( | 2013-12-19 |
20130337578 | MICROFLUIDIC DEVICE WITH AUXILIARY AND BYPASS CHANNELS - The invention is directed to a microfluidic device having a flow inlet and outlet, generally defining a flow direction. A bypass channel ( | 2013-12-19 |
20130337579 | Methods for Determining Protein Ligand Binding - Provided is a high-throughput differential radial capillary action of ligand assay (DRaCALA) that can be used to detect ligand binding to a protein. The assay is rapid, quantitative and allows detection of protein-ligand interactions for both purified proteins and proteins expressed in whole cells, which eliminates the need for protein purification. The method does not require a wash step, and can be performed without a drying step and without the aid of electrophoretic techniques. The method entails separating unbound ligand from bound ligand by placing a liquid composition that contains or is suspected of containing a protein and a detectably labeled ligand on a dry porous membrane to obtain a location on the membrane that contains the protein. Ligand that is bound to the protein does not migrate away from the location while unbound ligand radially migrates away from the location by capillary action, which separates unbound from bound ligand. The method includes determining whether a ligand binds to one or more proteins and whether a test composition contains a protein. | 2013-12-19 |
20130337580 | Immunoassay Device and Method - Devices, methods and kits for the detection of analytes in liquid samples. A device for conducting an assay to determine the presence or amount of an analyte in a fluid sample having a flow path matrix that facilitates fluidic flow and a fluid impermeable barrier. The flow path includes a first region on a top side of the barrier that facilitates fluid flow in a first direction and comprises a sample entry area and a second region on a bottom side of the barrier that facilitates fluid flow in a second direction substantially opposite the first direction and comprises a detection zone. Methods using the devices. Kits including the devices and various reagents necessary for conducting the methods. | 2013-12-19 |
20130337581 | NUCLEOBASE-FUNCTIONALIZED CONFORMATIONALLY RESTRICTED NUCLEOTIDES AND OLIGONUCLEOTIDES FOR TARGETING NUCLEIC ACIDS - Embodiments are disclosed herein that involve C5-functionalized nucleic acids, which can be used for detecting a target in a nucleic acid. Particular embodiments disclose methods for making these compounds, wherein the compounds can be formed by coupling of an intermediate with a linker. Certain embodiments disclose the use of these compounds for detecting single nucleotide polymorphisms, and for increasing the thermal affinity of nucleic acid complements as compared to unmodified nucleic acid complements. In addition, the disclosed compounds can decrease enzymatic degradation of nucleic acids. | 2013-12-19 |
20130337582 | MRAM ETCHING PROCESSES - Various embodiments of the invention relate to etching processes used in fabrication of MTJ cells in an MRAM device. The various embodiments can be used in combination with each other. The first embodiment adds a hard mask buffer layer between a hard mask and a top electrode. The second embodiment uses a multilayered etching hard mask. The third embodiment uses a multilayered top electrode structure including a first Cu layer under a second layer such as Ta. The fourth embodiment is a two-phase etching process used for the bottom electrode to remove re-deposited material while maintaining a more vertical sidewall etching profile. In the first phase the bottom electrode layer is removed using carbonaceous reactive ion etching until the endpoint. In the second phase an inert gas and/or oxygen plasma is used to remove the polymer that was deposited during the previous etching processes. | 2013-12-19 |
20130337583 | METHOD FOR REPAIRING DAMAGE OF DIELECTRIC FILM BY CYCLIC PROCESSES - A method for repairing process-related damage of a dielectric film includes: (i) adsorbing a first gas containing silicon on a surface of the damaged dielectric film without depositing a film in the absence of reactive species, (ii) adsorbing a second gas containing silicon on a surface of the dielectric film, followed by applying reactive species to the surface of the dielectric film, to form a monolayer film thereon, and (iii) repeating step (ii). The duration of exposing the surface to the first gas in step (i) is longer than the duration of exposing the surface to the second gas in step (ii). | 2013-12-19 |
20130337584 | SHAPE SIMULATION APPARATUS, SHAPE SIMULATION PROGRAM, SEMICONDUCTOR PRODUCTION APPARATUS, AND SEMICONDUCTOR DEVICE PRODUCTION METHOD - Disclosed herein is a shape simulation apparatus including: a flux computation block configured to compute the flux of particles incident on the surface of a wafer covered with a mask; and a shape computation block configured to compute a surface shape of the wafer by allowing the coordinates of a plurality of calculation points established on the surface of the wafer to be time-evolved based on the incident flux computed. | 2013-12-19 |
20130337585 | MULTIPLE OPTICAL WAVELENGTH INTERFEROMETRIC TESTING METHODS FOR THE DEVELOPMENT AND EVALUATION OF SUBWAVELENGTH SIZED FEATURES WITHIN SEMICONDUCTOR DEVICES AND MATERIALS, WAFERS, AND MONITORING ALL PHASES OF DEVELOPMENT AND MANUFACTURE - Methods and systems for resolving and determining sub-wavelength sized features and stresses by using infrared optical and thermal wavelength probing for holographic or interferometric evaluation and testing for all phases of semiconductor device development and manufacture. Specifically, systems and methods are disclosed for extending the range of optical holographic interferometric inspection for testing and evaluating microelectronic devices and determining the interplay of electromagnetic signals and dynamic stresses to the semiconductor material in which an enhanced imaging method provides continuous and varying magnification of the optical holographic interferometric images over a plurality of interleaved optical pathways of varying optical paths and imaging devices. Electronic analysis of holographic interference patterns of varying optical probing wavelengths determines and permits the display of internal and external stresses and the various effects of such stresses acting upon the operating characteristics of semiconductor devices, features, interior structures at any stage of development or manufacture. | 2013-12-19 |
20130337586 | POLISHING METHOD - A method of polishing a substrate includes: performing a first polishing process of bringing the substrate into sliding contact with a polishing pad on a first polishing table to polish a metal film; performing a second polishing process of bringing the substrate into sliding contact with a polishing pad on a second polishing table to polish the metal film until a conductive film is exposed; performing a third polishing process of bringing the substrate into sliding contact with a polishing pad on a third polishing table to polish at least the conductive film; and performing a fourth polishing process of bringing the substrate into sliding contact with a polishing pad on a fourth polishing table to polish at least a dielectric film. | 2013-12-19 |
20130337587 | METHODS OF ADDING PADS AND ONE OR MORE INTERCONNECT LAYERS TO THE PASSIVATED TOPSIDE OF A WAFER INCLUDING CONNECTIONS TO AT LEAST A PORTION OF THE INTEGRATED CIRCUIT PADS THEREON - A pattern of conductive ink is disposed on the topside of the unsingulated integrated circuits of a wafer, and, typically after wafer probing, the pattern of conductive ink is removed. The conductive ink pattern provides an electrical pathway between bond pads on an integrated circuit and large contact pads disposed on the topside of the integrated circuit. Each of the large contact pads is much greater in area than the corresponding bond pads, and are spaced apart so that the pitch of the large contact pads is much greater than that of the bond pads. In one aspect of the present invention, the conductive ink includes a mixture of conductive particles and wafer bonding thermoset plastic. In another aspect of the present invention, the conductive ink is heated and disposed on a wafer by an ink jet printing system. | 2013-12-19 |
20130337588 | MASK FOR DEPOSITION AND METHOD FOR MANUFACTURING ORGANIC LIGHT EMITTING DIODE DISPLAY USING THE SAME - A deposition mask for forming an organic layer pattern of an organic light emitting diode (OLED) display includes a base member having a first surface facing a substrate of the OLED display, and a second surface facing a side opposite to the first surface, and including a plurality of openings passing through the first surface and the second surface for forming the organic layer pattern. The opening has a pair of first side walls and a pair of second side walls. Each side wall of the openings has an inclination surface inclined with respect to a thickness direction of the base member, and when measuring an inclination angle of the inclination surface with reference to the first surface of the base member, the inclination angle of the first side wall and the inclination angle of the second side wall are different from each other. | 2013-12-19 |
20130337589 | FABRICATING METHOD FOR LIGHT EMITTING DIODE - A fabricating method for a light emitting diode, includes: providing a bonding substrate; providing an epitaxial structure having an epitaxial substrate and an epitaxial layer, in which the epitaxial layer has a first surface and a second surface opposite to each other, and the epitaxial substrate and the epitaxial layer are combined at the first surface; forming at least one gas discharge channel in the periphery of each single die structure on the epitaxial layer; applying an adhesive on the second surface of the epitaxial layer and the bonding substrate; vaporizing volatile organic gases in the adhesive, and bonding the epitaxial structure and the bonding substrate; removing the epitaxial substrate to expose the first surface of the epitaxial layer; forming electrodes on the exposed first surface of the epitaxial layer; and forming a plurality of light emitting diode dies through cutting along the periphery of each single die structure. | 2013-12-19 |
20130337590 | METHOD FOR FABRICATING SIDE BY SIDE LIGHT EMITTING DIODE (LED) HAVING SEPARATE ELECTRICAL AND HEAT TRANSFER PATHS - A method for fabricating a light emitting diode includes the steps of providing a thermal conductive substrate having an electrical isolation layer, forming an anode via and a cathode via side by side on a first side of the substrate part way through the substrate, forming an anode through interconnect in the anode via and a cathode through interconnect in the cathode via, thinning the substrate from a second side of the substrate to the anode through interconnect and the cathode through interconnect, and mounting a LED chip to the first side in electrical communication with the cathode through interconnect and the anode through interconnect. | 2013-12-19 |
20130337591 | LIGHT-EMITTING DEVICE - A method of manufacturing a light-emitting device includes forming a first optical element on a first carrier, wherein the first optical element comprises an opening; forming a light-emitting element in the opening; forming a second carrier on the first optical element; removing the first carrier after forming the second carrier on the first optical element; and forming a conductive structure under the first optical element. | 2013-12-19 |
20130337592 | MICRO-BEAD BLASTING PROCESS FOR REMOVING A SILICONE FLASH LAYER - Using compression molding to form lenses over LED arrays on a metal core printed circuit board leaves a flash layer of silicone covering the contact pads that are later required to connect the arrays to power. A method for removing the flash layer involves blasting particles of sodium bicarbonate at the flash layer. A nozzle is positioned within thirty millimeters of the top surface of the flash layer. The stream of air that exits from the nozzle is directed towards the top surface at an angle between five and thirty degrees away from normal to the top surface. The particles of sodium bicarbonate are added to the stream of air and then collide into the top surface of the silicone flash layer until the flash layer laterally above the contact pads is removed. The edge of silicone around the cleaned contact pad thereafter contains a trace amount of sodium bicarbonate. | 2013-12-19 |
20130337593 | METHOD FOR PRODUCING A PLURALITY OF SEMICONDUCTOR COMPONENTS - A method for producing a plurality of radiation-emitting semiconductor components ( | 2013-12-19 |
20130337594 | METHOD FOR MANUFACTURING LIGHT EMITTING DIODE PACKAGE - A method for manufacturing LED packages includes following steps: providing an engaging frame including a lead frame, electrode structures having first and second electrodes, and defining slots between the electrode structure, each first electrode including a first inserting part and each second electrode including a second inserting part; | 2013-12-19 |
20130337595 | Light-Emitting Device and Method for Manufacturing the Same - The present invention provides an organic light-emitting element where a lower electrode, an organic compound layer and an upper electrode are laminated on a substrate, wherein the upper electrode of the organic EL element is formed by a laminate of at least a conductive first inorganic film, a conductive organic film and a conductive second inorganic film, in order to suppress the occurrence of dark spot, so that the occurrence of pinholes in the upper electrode leading to dark spots is suppressed. Here, pinholes refer to holes in the upper electrode that penetrate upper electrode from the organic compound layer underneath to the atmosphere above. | 2013-12-19 |