| 51st week of 2009 patent applcation highlights part 48 |
| Patent application number | Title | Published |
|---|
| 20090312518 | INSULATING POLYMER MATERIAL COMPOSITION - An insulating polymer material composition is obtained by adding an acid anhydride as a curing agent and an organic peroxide such as dicumyl peroxide as a curing accelerator (for example, in an amount of 0.5 to 16.0 phr) to an epoxidized linseed oil, kneading the resulting under conditions according to the added amounts, and then heat-treating the kneaded substance, thereby causing peroxide vulcanization and three-dimensional crosslinking. This insulating polymer material composition is applied to polymer products such as high-voltage devices. | 2009-12-17 |
| 20090312519 | Bismaleamic acid, bismaleimide and cured product thereof - A bismaleamic acid obtained by reacting a bifunctional phenylene ether oligomer diamine, obtained by introducing aromatic amino groups into both terminals of a specific bifunctional phenylene ether oligomer, with maleic anhydride, a bismaleimide obtained from the bismaleamic acid as a raw material, which bismaleimide has high heat resistance, low dielectric characteristics and excellent solvent solubility and exhibits only a small change in dielectric characteristics even in high humidity, a curable resin composition containing the above bismaleimide and a cured product obtained by curing the curable resin composition. | 2009-12-17 |
| 20090312520 | Triazine-Based Monomeric Compound, Di-Triazine Compound, and Degradable Polymer - A triazine-based monomeric compound represented by the following formula (I): | 2009-12-17 |
| 20090312521 | Antibiotic drosocin derivatives - The invention concerns derivatives of drosocin which have an increased half-life in mammalian serum by substituting one or more of the amino acid residues of wild type drosocin with another amino acid or a peptidomimetic moiety capable of replacing said amino acid. These derivatives can be used for antibiotic therapy or in a bacteriocidal composition. | 2009-12-17 |
| 20090312522 | SYNTHETIC ACTIVE PEPTIDE FRAGMENTS - The present invention relates to peptide fragments which have one or more shared and/or similar amino acid sequences to amino acid sequences of specific portions of the 14 kDa protein of | 2009-12-17 |
| 20090312523 | METHODS AND APPARATUS FOR CONTINUOUS LARGE-SCALE RADIOLABELING - Disclosed are improved methods and apparatus for radiolabeling, particularly methods and apparatus for large scale in-line radiolabeling of products, such as proteins and antibodies. | 2009-12-17 |
| 20090312524 | COMPOSITIONS AND METHODS COMPRISING COLLAGEN - In various embodiments, a collagen product is provided that is derived from an animal, the collagen product comprises precipitated collagen that is substantially pure. In various embodiments, the collagen is obtained from a marine animal and does not contain prions or viruses. In various embodiments, the collagen can be made or incorporated into collagen films, collagen membranes, cosmetic collagen masks, collagen sponges, gelatin, hemostasis sponges, lyophilized foams, collagen injections, artificial skins and dura, bones, cartilage, screws, shafts, stems, or tube guides. | 2009-12-17 |
| 20090312525 | ISOLATED AQUAPORIN IN ITS CLOSED CONFORMATION - The invention relates to an isolated aquaporin having a bound ligand, wherein said ligand close the conformation of said aquaporin and inhibit and/or reduce water transport of said aquaporin, and/or a high resolution structure of an isolated aquaporin in a closed conformation characterised by the coordinates deposited at the Protein Data Bank ID:1Z98, a crystal of said isolated aquaporin as well as the coordinates defining said crystal and the use of said aquaporin, and the use of the high-resolution structure as defined by the coordinates deposited at PDB ID:1Z98, and a method to produce said aquaporin. | 2009-12-17 |
| 20090312526 | METHOD FOR PRODUCING ANTIBODIES - The present invention relates to a method for producing antibodies and to antibodies produced by this method. In one embodiment the invention relates to a method for producing an antibody that binds to a polypeptide of a first species, the method comprising immunizing a mammal of a second species with cells derived from a transgenic mammal of the second species, wherein the polypeptide of the first species is expressed on the surface of the cells derived from the transgenic mammal. | 2009-12-17 |
| 20090312527 | Novel monoclonal antibodies against HPV proteins - Embodiments of the invention provide methods, monoclonal antibodies, polyclonal antibodies, assays, and kits for detecting HPV infection and HPV related cancer diagnosis, including infection by various HPV genotypes, early and/or late stage HPV-associated or HPV-specific cancers. Various monoclonal antibodies recognizing specific epitope for specific HPV protein or HPV type, common epitope for various HPV proteins or HPV types are obtained. These obtained monoclonal antibodies are useful tools in early clinical detection of HPV infection and general detection of HPV related diseases, specific detection of invasive cervical cancer, detection of other HPV related cancers, early stage precancerous lesions as well as late stage cancer progression. | 2009-12-17 |
| 20090312528 | Method of Producing a Set of MHC Molecules - The present invention relates to a method of producing a set of MHC molecules, and more precisely to a method of producing a set of MHC molecules which differ in their peptide bound in the binding groove. The method allows for parallel and rapid synthesis of different MHC molecules at high yields for each molecule. | 2009-12-17 |
| 20090312529 | MOLECULAR MANIPULATOR, A METHOD OF MAKING THE SAME, AND A METHOD OF MOVING A NANOSTRUCTURE - A molecular manipulator includes a light-sensitive molecule, including a double bond, which changes a cis-trans configuration of the double bond in response to illumination by light of a selected wavelength, and a probe, for example, a probe of a scanned-proximity probe microscope, to which the light-sensitive molecule is attached. A method of making the molecular manipulator includes covalently bonding the light-sensitive molecule to the probe. A method of moving a nanostructure includes controllably grasping, moving, and releasing the nanostructure with the molecular manipulator. | 2009-12-17 |
| 20090312530 | Processes for the convergent synthesis of calicheamicin derivatives - This invention describes processes for the convergent synthesis of calicheamicin derivatives, and similar analogs using bifunctional and trifunctional linker intermediates. | 2009-12-17 |
| 20090312531 | OLIGNUCLEOTIDES COMPRISING A LIGAND TETHERED TO A MODIFIED OR NON-NATURAL NUCLEOBASE - One aspect of the present invention relates to a double-stranded oligonucleotide comprising at least one ligand tethered to an altered or non-natural nucleobase. In certain embodiments, the non-natural nucleobase is difluorotolyl, nitropyrrolyl, or nitroimidazolyl. In certain embodiments, the ligand is a steroid or aromatic compound. In certain embodiments, only one of the two oligonucleotide strands comprising the double-stranded oligonucleotide contains a ligand tethered to an altered or non-natural nucleobase. In certain embodiments, both of the oligonucleotide strands comprising the double-stranded oligonucleotide independently contain a ligand tethered to an altered or non-natural nucleobase. In certain embodiments, the oligonucleotide strands comprise at least one modified sugar moiety. Another aspect of the present invention relates to a single-stranded oligonucleotide comprising at least one ligand tethered to an altered or non-natural nucleobase. In certain embodiments, the non-natural nucleobase is difluorotolyl, nitropyrrolyl, or nitroimidazolyl. In certain embodiments, the ligand is a steroid or aromatic compound. In certain embodiments, the ribose sugar moiety that occurs naturally in nucleosides is replaced with a hexose sugar, polycyclic heteroalkyl ring, or cyclohexenyl group. In certain embodiments, at least one phosphate linkage in the oligonucleotide has been replaced with a phosphorothioate linkage. | 2009-12-17 |
| 20090312532 | Modulation of exon recognition in pre-mrna by interfering with the binding of sr proteins and by interfering with secodary rna structure - The invention provides a method for generating an oligonucleotide with which an exon may be skipped in a pre-mRNA and thus excluded from a produced mRNA thereof. Further provided are methods for altering the binding of an SR protein and/or methods for altering the secondary structure of an mRNA to interfere with splicing processes and uses of the oligonucleotides and methods in the treatment of disease. Further provided are pharmaceutical compositions and methods and means for inducing skipping of several exons in a pre-mRNA. | 2009-12-17 |
| 20090312533 | SINGLE COPY GENOMIC HYBRIDIZATION PROBES AND METHOD OF GENERATING SAME - Nucleic acid (e.g., DNA) hybridization probes are described which comprise a labeled, single copy nucleic acid which hybridizes to a deduced single copy sequence interval in target nucleic acid of known sequence. The probes, which are essentially free of repetitive sequences, can be used in hybridization analyses without adding repetitive sequence-blocking nucleic acids. This allows rapid and accurate detection of chromosomal abnormalities. The probes are preferably designed by first determining the sequence of at least one single copy interval in a target nucleic acid sequence, and developing corresponding hybridization probes which hybridize to at least a part of the deduced single copy sequence. In practice, the sequences of the target and of known genomic repetitive sequence representatives are compared in order to deduce locations of the single copy sequence intervals. The single copy probes can be developed by any variety of methods, such as PCR amplification, restriction or exonuclease digestion of purified genomic fragments, or direct synthesis of DNA sequences. This is followed by labeling of the probes and hybridization to a target sequence. | 2009-12-17 |
| 20090312534 | METHOD FOR REMOVAL OF NUCLEIC ACID-PROTECTING GROUP - A method is provided for efficiently removing the silicon substituent which protects the 3′-hydroxyl group and the 5′-hydroxyl group of a ribose of a ribonucleic acid derivative in which the 2′-hydroxyl group of the ribose is protected with the following substituent (I) | 2009-12-17 |
| 20090312535 | CELLULOSE RESIN FILM AND METHOD FOR PRODUCING THE SAME - There is provided a method for producing a high-quality cellulose resin film which has fewer foreign matter-related faults, and therefore is excellent for optical applications. The method for producing a cellulose resin film, includes the steps of: melting a cellulose resin fed from a hopper in an extruder; feeding the molten resin from the extruder into a die; extruding the molten resin from the die to form a sheet; and cooling and solidifying the sheet, wherein the sheet has 30 or less foreign matters of 30 μm or larger in size per square meter and 100 or less foreign matters of 5 μm or larger in size per square meter. | 2009-12-17 |
| 20090312536 | Process For Producing A Pulp - The invention relates to a process for producing a dissolving pulp from a cellulosic starting material using the kraft process, comprising the step of cooking the starting material with a cooking liquor. The process according to the invention characterized in that the starting material is exposed to a steam treatment prior to cooking and that the pulp obtained by cooking is subjected to cold caustic extraction (CCE) in the course of further processing. | 2009-12-17 |
| 20090312537 | CARBOHYDRATES - Carbohydrates having functional groups, such as carboxylic acid groups and methods of making such carbohydrates. | 2009-12-17 |
| 20090312538 | PROCESS FOR THE PREPARATION OF SUCRALOSE OF HIGH PURITY - The present invention relates to an improved process for the preparation of Sucralose having purity of at least 99.6% comprising steps of
| 2009-12-17 |
| 20090312539 | AN IMPROVED PROCESS FOR THE PREPARATION OF CARBAPENEM ANTIBIOTIC - The present invention provides a process for the preparation of the carbapenem antibiotic of formula (I) or its salt in amorphous form. Formula (I) wherein R represents hydrogen or COOM and M represents hydrogen or sodium. | 2009-12-17 |
| 20090312540 | SPATIALLY-DEFINED MACROCYCLES INCORPORATING PEPTIDE BOND SURROGATES - Novel spatially-defined macrocyclic compounds incorporating peptide bond surrogates are disclosed. Libraries of these macrocycles are then used to select one or more macrocycle species that exhibit a specific interaction with a particular biological target, in particular, compounds according to the invention are disclosed as agonists or antagonists of a mammalian motilin receptor and a mammalian ghrelin receptor. | 2009-12-17 |
| 20090312541 | Process for preparing pharmaceutical compound and intermediates thereof - The present invention relates to novel intermediates of formula VII, | 2009-12-17 |
| 20090312542 | SYSTEM AND METHOD FOR RECOVERING CAPROLACTAM FROM REARRANGEMENT MIXTURES - A system and a method for recovering caprolactam from a rearrangement mixture are provided. The system includes a neutralization unit; a buffering unit for receiving a crude lactam solution containing impurities content below a standard value and being fed from the neutralization unit; a temporary storage unit for receiving a crude lactam solution containing impurities above the standard value and being fed from the neutralization unit; a temporary extraction unit for performing batch extraction to separate out a first lactam solution; an extraction unit for performing continuous extraction to separate out a second lactam solution; and a recovery unit for allowing caprolactam to be recovered. In the present system and method, the crude lactam solution is selectively fed into the extraction unit for continuous extraction or to the temporary extraction unit for batch extraction, thereby maintaining continuity of operation, enhancing separation efficiency, and reducing both material consumption and purification loadings. | 2009-12-17 |
| 20090312543 | PYRAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS - This invention describes novel pyrazole compounds of formula IIIa: | 2009-12-17 |
| 20090312544 | METHOD FOR PREPARING LAMORTRIGINE AND ITS INTERMEDIATE 2,3-DICHLOROBENZOYL CHLORIDE - A method for preparing 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine, commonly known as lamotrigine, is disclosed. A method of preparing the intermediate, 2,3-dichlorobenzoyl chloride, by photochlorination of 2,3-dichlorobenzotrichloride followed by hydrolysis is also disclosed. The intermediate may then be used in the preparation of lamotrigine. | 2009-12-17 |
| 20090312545 | PROCESS FOR PREPARING TRIALLYL ISOCYANURATE (TAIC) - The invention is directed to an improved, reliably performable process for preparing triallyl isocyanurate (TAIC) by Cu | 2009-12-17 |
| 20090312546 | QUINOLINE AND QUINAZOLINE DERIVATIVES HAVING AFFINITY FOR 5HT1-TYPE RECEPTORS - Disclosed are methods for the preparation of compounds of formula (I): | 2009-12-17 |
| 20090312547 | PROCESS FOR PREPARATION OF ROSUVASTATIN CALCIUM FIELD OF THE INVENTION - The present invention relates to an improved process for preparing (E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl](3R,5S)-3,5-dihydroxyhept-6-enoic acid calcium of Formula (I). | 2009-12-17 |
| 20090312548 | MODIFIED PICTET-SPENGLER REACTION AND PRODUCTS PREPARED THEREFROM - A method of introducing a second stereogenic center into a tetrahydro-β-carboline have two stereogenic centers using a modified Pictet-Spengler reaction is disclosed. The method provides a desired cis- or trans-isomer in high yield and purity, and in short processes times. | 2009-12-17 |
| 20090312549 | METHOD OF PREPARATION OF AZAINDOLE DERIVATIVES - A method of preparing azaindole compounds for antiviral use having the formula | 2009-12-17 |
| 20090312550 | ZIPRASIDONE FREE FROM COLORED IMPURITIES AND A PROCESS FOR ITS PREPARATION - Ziprasidone base or a pharmaceutically acceptable salt thereof free from colored impurities, in particular those giving the product a “slightly pink to pink” coloration. | 2009-12-17 |
| 20090312551 | Process for producing biphosphonic acids and forms thereof - Disclosed herein is a process for producing bisphosphonic acids and salts thereof. The process comprising reacting a carboxylic acid of Formula [I] with phosphorous acid and halophosphorus compound in the presence of a solvent selected from aliphatic hydrocarbon or water miscible cyclic ether. Further, the present invention also provides novel forms of bisphosphonic acids and process for preparation thereof. | 2009-12-17 |
| 20090312552 | Process for the Preparation of 6-Beta Hydroxy Morphinan Compounds - The invention provides processes for the conversion of a 6-keto morphinan to a 6-hydroxy morphinan. In particular, the invention provides a stereoselective process for the conversion of a 6-keto morphinan to a 6-beta-hydroxy morphinan. | 2009-12-17 |
| 20090312553 | N-TYPE SEMICONDUCTOR MATERIALS FOR THIN FILM TRANSISTORS - A thin film transistor comprises a layer of organic semiconductor material comprising a tetracarboxylic diimide naphthalene-based compound having, attached to each of the imide nitrogen atoms, an aromatic moiety, at least one of which moieties is substituted with at least one electron donating group. Such transistors can further comprise spaced apart first and second contact means or electrodes in contact with said material. Further disclosed is a process for fabricating an organic thin-film transistor device, preferably by sublimation deposition onto a substrate, wherein the substrate temperature is no more than 100° C. | 2009-12-17 |
| 20090312554 | Novel Process for the Preparation of Hexacyclic Compounds - This invention relates to novel processes for the preparation of compounds of the formula [1], | 2009-12-17 |
| 20090312555 | PROCESS AND INTERMEDIATE COMPOUNDS USEFUL IN THE PREPARATION OF STATINS - There is provides a process for the preparation of a compound of formula (7): wherein R is an optionally substituted hydrocarbyl group or an optionally substituted heterocyclic group; provides that R is not a compound of Formula (a): wherein R | 2009-12-17 |
| 20090312556 | N-(2-AMINIPHENYL)-4-(5-((ETHYLAMINO)METHYL)-1,2-THIAZOL-2-YL) BENZAMIDE AND N-(2-AMINOPHENYL)-4-(5-((ISOPROPYLAMINO)METHYL)-1,2-THIAZOL-2-YL) BENZAMIDE AS HDAC INHIBITORS - The invention concerns novel benzamide compounds of Formula (I): wherein R wherein is ethyl or isopropyl; or a pharmaceutically acceptable salt or pro-drug form thereof. The invention also concerns processes for the preparation of such compounds, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an antiproliferative agent in the prevention or treatment of tumours or other proliferative conditions, which are sensitive to the inhibition of histone deacetylase (HDAC). | 2009-12-17 |
| 20090312557 | PROCESS FOR THE PREPARATION OF EPSILON -ALKOXYCARBONYLLYSINES AND THEIR ANALOGUES - A process for the preparation of ω-alkoxycarbonylamino-α-aminoacids and α,ω orthogonally diprotected diaminoacids from α,ω-diaminoacids using 1-alkoxycarbonylbenzotriazoles as protecting agents is disclosed. In an alternative embodiment, carbamoylating agents in the presence of benzotriazoles are used instead of 1-alkoxycarbonylbenzotriazoles. This reaction is preferably applied to the preparation of ε-alkoxycarbonyllysines from lysine. A process for the preparation of t-butoxycarbonylbenzotriazoles and novel complexes of ω-alkoxycarbonylamino-α-aminoacids with benzotriazoles are also disclosed. | 2009-12-17 |
| 20090312558 | PROCESS FOR THE PREPARATION OF ARYLCYCLOPROPOANE CARBOXYLIC CARBONITRILES, AND COMPOUNDS DERIVED THEREFROM - The present invention relates to an efficient process for preparing an arylcyclopropanecarbonitrile, which involves the use of sulfolane as a solvent. | 2009-12-17 |
| 20090312559 | CATALYTIC ENANTIOSELECTIVE SILYLATIONS OF SUBSTRATES - The present invention provides methods, compositions and systems for silylation of substrates, including direct asymmetric silylation of a substrate to provide enantiomerically enriched silylated products. | 2009-12-17 |
| 20090312560 | PROCESSES FOR MAKING PREGABALIN AND INTERMEDIATES THEREFOR - Processes for making a diester compound of formula (B) and for converting it to pregabalin, especially via a compound of formula (2), can provide several advantages. | 2009-12-17 |
| 20090312561 | METAL COMPLEXES - The invention concerns metal complexes and their preparation, in particular a metal complex MLnXm, where M is a metal of group 8, 9 or 10 and X is a halide, HCO3—, NO3—, CO32— or carboxylate. n is a number equal to or less than the coordination number of the metal and m is 1 or 2 and is equal to the oxidation state of the metal. The ligand L may be a bidentate phosphine of formula (I), (II), (III) or (IV) as set out herein. The process of production comprises reacting an ammine compound of metal M with a complexing compound, which is preferably a phosphine. | 2009-12-17 |
| 20090312562 | Catalyst Containing Titanium Dioxide, Particularly for the Production of Phthalic Anhydride - The present invention relates to the use of titanium dioxide having a content of sulphur, calculated as elemental sulphur, of less than about 1000 ppm and a BET surface area of at least 5 m | 2009-12-17 |
| 20090312563 | SALT OF (2S, 3S)-3-[[ (1S)-1-ISOBUTOXYMETHYL-3-METHYLBUTYL] CARBAMOYL] OXIRANE-2-CARBOXYLIC ACID - The invention relates to purification of (2S,3S)-3-[[(1S)-1-isobutoxymethyl-3-methylbutyl]carbamoyl]oxirane-2-carboxylic acid [hereinafter, referred to as the carboxylic acid] using the salt of the carboxylic acid with an organic amine selected from the group consisting of piperazine, adamantane amines and others. The invention also relates to providing crystalline sodium salt of the carboxylic acid. The sodium salt is usable as a material for preparing medicaments and improved in storage stability, and has the following characteristics:
| 2009-12-17 |
| 20090312564 | METHOD FOR THE PURIFICATION OF RADIOLABELLED COMPOUNDS - The invention relates to methods and apparatus for purifying a radiolabelled compound. The method comprises (i) passing a crude reaction mixture comprising the desired radiolabelled compound and one or more contaminants in a solvent through a narrow bore vessel at elevated temperature such that the organic solvent and either the radiolabelled compound or one or more contaminants is vaporised forming a vaporised component, and (ii) collecting the resulting vaporised component by condensing into a collection vessel. | 2009-12-17 |
| 20090312565 | Compositions of AU-11 nanoparticles and their optical properties - As demonstrated herein, the ligand exchange chemistry of phosphine-stabilized Au | 2009-12-17 |
| 20090312566 | Multiply substituted ferrocenes - Disclosed are compounds of formulas (I) and (II) in the form of enantiomer-pure diastereomers or diastereomer mixtures. In said formulas (I) and (II), R′ | 2009-12-17 |
| 20090312567 | SYSTEM AND METHOD FOR SUPPRESSING SUBLIMATION OF MATERIALS DURING CHEMICAL TRANSFORMATION AT HIGH TEMPERATURES - An apparatus for use in reactions of materials with a propensity for sublimation at high temperatures has a central chamber that is immersed in a reaction vessel, attached with an air tight joint. The chamber is surrounded by a cooling jacket filled with a circulating medium, the temperature of which is adjusted below the temperature of the solution of reactants. The central chamber is immersed into the mixture and is partially filled with a liquid. This liquid is cooled by the medium circulating in the cooling jacket. The cooling ensures that the liquid filling the tube has a lower temperature than the mixture, preventing sublimation of the materials. | 2009-12-17 |
| 20090312568 | POLYHEDRAL OLIGOMERIC SILSESQUIOXANE AND CARBORANE CONTAINING NETWORK - A thermoset and method of making such by crosslinking a mixture of a polyhedral oligomeric silsesquioxane having pendent siloxane groups or unsaturated carbon bonds and a siloxylcarborane compound having unsaturated carbon bonds. | 2009-12-17 |
| 20090312569 | NOVEL PROCESS - The present invention relates to a process for the preparation of 1-(2-ethyl-butyl)-cyclohexanecarboxylic acid which is useful as an intermediate in the preparation of pharmaceutically active compounds. | 2009-12-17 |
| 20090312570 | PYRRO[1,2-b]PYRIDAZINONE COMPOUNDS - The invention is directed to pyrro[1,2-b]pyridazinone compounds and pharmaceutical compositions containing such compounds that are useful in treating infections by hepatitis C virus. | 2009-12-17 |
| 20090312571 | PROCESS FOR THE PREPARATION OF (3S)-3-AMINO-N-CYCLOPROPYL-2-HYDROXYALKANAMIDE DERIVATIVES - The present invention relates to a process for the preparation of (2S,3S)-3-amino-N-cyclopropyl-2-hydroxyalkanamides as well as novel compounds prepared or used in the process. | 2009-12-17 |
| 20090312572 | Bioabsorbable Surgical Composition - Compounds are provided which can form bioabsorbable compositions useful as adhesives or sealants for medical/surgical applications. | 2009-12-17 |
| 20090312573 | POSITIVE RESIST COMPOSITION, METHOD OF FORMING RESIST PATTERN, POLYMERIC COMPOUND, AND COMPOUND - A compound represented by general formula (I) shown below; and a polymeric compound having a structural unit (a0) represented by general formula (a0-1) shown below: | 2009-12-17 |
| 20090312574 | Method for Producing Optically Active Fluorine-Containing Carbonyl-ene Product - An optically active, fluorine-containing carbonyl-ene product is produced by reacting a fluorine-containing α-ketoester with an alkene in the presence of a transition metal complex having an optically active ligand. There are Mode 1 of conducting this reaction in the absence of reaction solvent, Mode 2 of conducting this reaction in a solvent that is low in relative dielectric constant, and Mode 3 of conducting this reaction in a halogenated hydrocarbon-series solvent. In each of these three modes, it is possible to produce the optically active, fluorine-containing carbonyl-ene product with low cost. | 2009-12-17 |
| 20090312575 | Process For Preparing A Benzoylbenzeneacetamide Derivative - Disclosed is a process for preparing anti-inflammatory compound nepafenac comprising preparing a compound of formula (V) wherein a N-halosuccinimide is used as the halogenating agent, followed by desulfurization using Raney Nickel. Also disclosed is a polymorphic form B of 2-amino-3-benzoyl-α-(methylthio)-benzeneacetamide (i.e., a compound of formula (V) wherein R is methyl | 2009-12-17 |
| 20090312576 | PROCESS AND INTERMEDIATES FOR THE PREPARATION OF 3-(AMINO)-3-CYCLOBUTYLMETHYL-2-HYDROXY-PROPIONAMIDE OR SALTS THEREOF - In one embodiment, the present application relates to a process of making a compound of formula I: | 2009-12-17 |
| 20090312577 | Process for Production of Beta-Amino-Alpha-Hydroxy Carbonxamide Derivative - Provided is a process for production of a β-amino-α-hydroxy carboxamide derivative that is important in production of drugs or the like. In the presence of a predetermined solvent, a β-(N-protected)amino-α-hydroxycarboxylic acid is reacted with an amine to conversion to a β-(N-protected)amino-α-hydroxy carboxamide derivative; then the derivative is deprotected for conversion to a β-amino-α-hydroxy carboxamide derivative; and the derivative is crystallized using a protic solvent to obtain a crystal. The high-purity β-amino-α-hydroxy carboxamide derivative can be stably produced on an industrial scale by the process. | 2009-12-17 |
| 20090312578 | PREPARATION OF (2R,3R)-3-(3-METHOXYPHENYL)-N,N,2-TRIMETHYLPENTANAMINE - The present invention relates to an improved process for the preparation of (2R,3R)-3-(3-methoxyphenyl)-N,N,2-trimethylpentanamine which is an intermediate for the preparation of the analgesic tapentadol. | 2009-12-17 |
| 20090312579 | METHOD FOR PRODUCING AN AMINE - Processes comprising: (i) providing a reactant selected from the group consisting of primary alcohols, secondary alcohols, aldehydes, ketones and mixtures thereof, and (ii) reacting the reactant with hydrogen and a nitrogen compound selected from the group consisting of ammonia, primary amines, secondary amines and mixtures thereof, in the presence of a catalyst comprising a zirconium dioxide- and nickel-containing catalytically active composition, to form an amine; wherein the catalytically active composition, prior to reduction with hydrogen, comprises oxygen compounds of zirconium, copper, and nickel, and one or more oxygen compounds of silver in an amount of 0.5 to 6% by weight, calculated as AgO. | 2009-12-17 |
| 20090312580 | Process For Producing Sec-Butylbenzene - A process for producing sec-butylbenzene comprises contacting a feed comprising benzene and a C | 2009-12-17 |
| 20090312581 | METHOD FOR DEHYDROGENATING ALCOHOLS - A method for dehydrogenating primary or secondary alcohols having 1 to 12 carbon atoms to give the corresponding aldehydes or ketones in which the alcohol is brought into contact with a catalytically active composition comprising an active component of the formula | 2009-12-17 |
| 20090312582 | Synthesis of butylated hydroxyanisole from tertiary butyl hydroquinone - A process for production and novel physical forms of butylated hydroxyanisole (BHA) wherein tertiary butyl hydroquinone (TBHQ) reacts within a range of about 30 to 50° C. with stoichiometrically slight excess of dimethyl sulphate and sodium hydroxide. The sodium hydroxide is added stoichiometrially in slight excess of dimethyl sulphate. A major portion of BHA formed in this reaction was recovered in a crystalline form in which 3-t-butyl-4-hydroxyanisole (3 isomer) is at least at a level of about 99%, usually at about 99.5% or more, and TBHQ at 100 ppm or less. BHA remaining in a mother liquor after crystallization was recovered by distillation and had the same purity as the crystalline BHA. The crystalline form was prepared as a low density, as well as a high density, form and could also be converted into compressed forms including flakes, tablets and the like. | 2009-12-17 |
| 20090312583 | PROCESS FOR CODIMERIZING OLEFINS - The present invention relates to a process for preparing olefin codimers, the olefin codimers which can be obtained by this process, a process for preparing alcohols in which such olefin codimers are subjected to hydroformylation and subsequent hydrogenation, the alcohol mixtures which can be obtained in this way and their use. | 2009-12-17 |
| 20090312584 | Process For Preparing High Purity TNT - A process for preparing trinitrololuene (TNT) in which toluene is treated with nitric acid having a concentration of about 90% to about 99%, and preferably about 98% to about 99%, by weight at a temperature of less than about 60° C., and preferably less than 30° C., to produce high purity dinitrotoluene. The resulting dinitrotoluene is then treated with nitric acid having a concentration of about 98% to about 99% by weight and trifluoromethane sulfuric acid to produce high purity TNT. | 2009-12-17 |
| 20090312585 | PROCESSES FOR HYDROFLUORINATION OF 2-CHLORO-3,3,3-TRIFLUOROPROPENE TO 2-CHLORO-1,1,1,2-TETRAFLUOROPROPANE - A process for making 2-chloro-1,1,1,2-tetrafluoropropane. The process has the step of contacting 2-chloro-3,3,3-trifluoropropene with hydrogen fluoride in the presence of a catalyst having about 25 to about 99.9 mole percent antimony pentachloride and about 0.1 to about 75 mole percent of a metal of a Lewis acid under conditions sufficient to form the 2-chloro-1,1,1,2-tetrafluoropropane. There is a second process for making 2-chloro-1,1,1,2-tetrafluoropropane. The process has the step of hydrofluorinating about 75 to about 99.9 mole percent 2-chloro-3,3,3-trifluoropropene and about 0.1 to about 25 mole percent of one or more other hydrocarbons having at least one chlorine atom in the presence of a catalyst of fluorinated antimony pentachloride under conditions sufficient to form the 2-chloro-1,1,1,2-tetrafluoropropane. There is yet another process for hydrofluorinating 2-chloro-3,3,3-trifluoropropene to 2-chloro-1,1,1,2-tetrafluoropropane. The process has the step of contacting the 2-chloro-3,3,3-trifluoropropene with hydrogen fluoride in the presence of a vapor phase catalyst under conditions sufficient to form the 2-chloro-1,1,1,2-tetrafluoropropane. | 2009-12-17 |
| 20090312586 | HYDROGENATION OF MULTI-BROMINATED ALKANES - Methods and systems for the hydrogenation of multi-brominated alkanes are provided herein. An embodiment of the present invention comprises a method, the method comprising: reacting at least hydrogen and multi-brominated alkanes in the presence of a catalyst to form a hydrogenated stream comprising brominated alkanes having fewer bromine substituents than the multi-brominated alkanes reacted with the hydrogen. Embodiments of the method further may comprise forming brominated alkanes. Embodiments of the method further may comprising forming product hydrocarbons from brominated alkanes. | 2009-12-17 |
| 20090312587 | PROCESS FOR THE PREPARATION OF ZEACAROTENES - The present invention relates to process for the preparation of zeacarotenes and to intermediates in the process for the preparation of zeacarotenes. | 2009-12-17 |
| 20090312588 | PROCESS FOR HYDROGENATING UNSATURATED HYDROCARBONS IN THE PRESENCE OF CATALYSTS CONTAINING COPPER AND ZINC - Unsaturated hydrocarbons are hydrogenated over catalysts which comprise copper and zinc and whose active composition, in unreduced form, consists essentially of from 10 to 95% by weight of copper oxide, calculated as copper(II) oxide (CuO), from 5 to 90% by weight of zinc oxide (ZnO), optionally from 0.1 to 50% by weight of zirconium dioxide (ZrO | 2009-12-17 |
| 20090312589 | Styrene Monomer Process Based on Oxidative Dehydrogenation of Ethylbenzene Using CO2 as a Soft Oxidant - Processes are provided for the production of styrene monomer by oxidative dehydrogenation of EB using CO | 2009-12-17 |
| 20090312590 | Process for the Production of Styrene Monomer by Improving Energy Efficiency and Injecting a Recycle Gas into the EB Vaporizer - This invention relates to a process for the production of styrene monomer by the dehydrogenation or oxidative dehydrogenation of ethylbenzene in the presence of recycle gas and more particularly to a method of reducing the boiling point of liquid ethylbenzene feed in the production of styrene monomer. The process comprises the step of catalytically dehydrogenating or oxydehydrogenating ethylbenzene in the presence of a mixture, wherein the mixture substantially comprises carbon dioxide, thereby catalytically producing styrene monomer. | 2009-12-17 |
| 20090312591 | METHOD FOR PRODUCING PROPENE FROM PROPANE - The present invention relates to processes for preparing propene from propane, comprising the steps:
| 2009-12-17 |
| 20090312592 | Swing Reactor and Process for Oxychlorination - A reactor with swing feeds is provided for oxychlorination. This reactor comprises multiple inlets with controls capable of introducing feed streams sequentially to the reactor. In one configuration, a feed stream comprises a paraffin hydrocarbon, and a second feed stream comprises oxygen and hydrogen chloride. By segregating these feeds, combustion reactions can be minimized and yields of chlorinated paraffins increased. | 2009-12-17 |
| 20090312593 | Radioactive Device for treatment of a Tumor - An apparatus in one example has a treatment balloon or similar device that may be implanted into a tumor bed or cavity, and filled with or carrying a radioactive material. | 2009-12-17 |
| 20090312594 | DEVICES TO RESIST MIGRATION AND ROTATION OF IMPLANTS USED IN BRACHYTHERAPY AND OTHER RADIATION THERAPY - A therapeutic member for use in brachytherapy deliverable to an implant site by way of a needle comprises a single radioactive source encapsulated by a bio-absorbable material having an outer surface including one or more ribs encircling the single radioactive source, a leading edge endcap rib and a trailing edge endcap rib. The one or more ribs reduces a tendency of the member to migrate and rotate within a patient's body after implantation. The encapsulating material further includes a first rail formed from the bio-absorbable material extending at least from opposite sides of the outer surface of the encapsulating material along the longitudinal axis of the therapeutic member, and a second rail formed from the bio-absorbable material extending at least from opposite sides of the outer surface of the encapsulating material along the longitudinal axis of the therapeutic member, the second rail arranged in a plane substantially perpendicular to a plane in which the first rail is arranged. Another embodiment includes wings that selectively extend from an implant preventing movement of the implant. | 2009-12-17 |
| 20090312595 | System and method for memory modification - Systems and methods are described relating to activating at least one consolidated memory of an individual; presenting an indication of at least one memory-dampening agent to the individual; and presenting to the individual at least one artificial sensory experience for reconsolidation of the at least one consolidated memory. | 2009-12-17 |
| 20090312596 | ASSAY AND KIT FOR PREDICTING IMPLANTATION SUCCESS IN ASSISTED FERTILISATION - The present invention relates to an assay for determining the implantation potential of a plurality of embryos each obtained or to be obtained by assisted fertilisation of an oocyte of a female subject, comprising measuring the levels of granulocyte-colony stimulating factor (G-CSF) in the follicular fluid (FF) present in the follicle from which each oocyte is derived, and determining the implantation potential of each embryo from the level of measured FF G-CSF. It also relates to a kit for carrying out the assay. It further relates to a method for assisted fertilisation. | 2009-12-17 |
| 20090312597 | Methods and devices for limiting gastric expansion - Disclosed are methods and devices for limiting expansion in at least one portion of gastric tissue. | 2009-12-17 |
| 20090312598 | CATHETER-BASED TISSUE REMODELING DEVICES AND METHODS - Devices and methods utilizing a catheter to remodel soft tissue of a patient and, in a preferred embodiment, to reduce the volume of the left ventricle of a heart. In some embodiments, one or more sutures are passed through a wall of the ventricle. The ends of the one suture and, more preferably, the multiples sutures are drawn together to draw tissue portions towards one another. In some embodiments, a tissue remodeling clip is implanted into a wall of the ventricle. Ends of the clip are resiliently biased to move relative to one another to draw tissue portions towards one another. In some embodiments, a tissue remodeling anchor includes a base and a plurality of legs attached to the base. The legs of the tissue anchor are implanted into a wall of the ventricle and moved toward one another to draw tissue portions toward one another. | 2009-12-17 |
| 20090312599 | Sexual stimulation apparatus - A sexual stimulation apparatus comprising a phallic shaped member having a handle disposed at its base. The handle has a convex surface substantially facing away from the phallic shaped member. The convex surface has at least one projection member extending therefrom. In use, the convex surface sits snugly against the palm and fingers of a user's hand, and the projection member interdigitally engages with the user's hand. | 2009-12-17 |
| 20090312600 | ENDOSCOPIC POSITIONING SYSTEM - It is one object of the present invention to provide an endoscope positioning system (EPS) for maneuvering, orienting and positioning an endoscope relatively to an organ being operated within a patient's body. The EPS is especially used during orthopedic operations such that the organ is constantly moved during the operation. The EPS includes: at least four freedom degree mechanisms (FDFM) that are adapted to actuate the distal portion of the endoscope by maneuvering the proximal portion of the endoscope; and at least one body adapter gripper adapted to reversibly and firmly attach the EPS to the patient's body. The FDFM includes at least a first, second, third and fourth means for providing the four degrees of freedom. The means of first degree of freedom is a rotation sub-mechanism adapted to rotate the endoscope around its longitudinal axis. The means of second degree of freedom is a tilting sub-mechanism. The means of third degree of freedom is an arch sub-mechanism. The means of fourth degree of freedom is a zoom mechanism. Each of the first, second, third and fourth degree of freedom is characterized by an independent movement. The EPS is conformed to the movements of the organ by the gripper such that the orientation of the endoscope is adjustable accordingly to the movement. | 2009-12-17 |
| 20090312601 | CAPSULE ENDOSCOPE SYSTEM - A capsule endoscope system includes: a receiving device that receives in-vivo images captured by a capsule endoscope inserted into an organ of a subject; and an image display device that acquires ID information of one or more capsule endoscopes, acquires through the receiving device the in-vivo images captured by the capsule endoscopes identified by the ID information, and displays thereon the in-vivo images thus acquired. The image display device is connected via a communication network to a central server that uniformly manages information about the capsule endoscopes, notifies the central server the ID information of the one or more capsule endoscopes, acquires information about the one or more capsule endoscopes from the central server, and performs a warning process about the one or more capsule endoscopes according to the information thus acquired. | 2009-12-17 |
| 20090312602 | PRESSING MEMBER, ENDOSCOPIC TREATMENT SYSTEM, AND ENDOSCOPIC SUTURING DEVICE - An endoscopic treatment system | 2009-12-17 |
| 20090312603 | ENDOSCOPIC TISSUE ANCHOR DEPLOYMENT - An endoscopic tissue anchor deployment device includes a handle, an elongated shaft defining an internal lumen, and an end effector attached to the distal end of the elongated shaft. A tissue anchor catheter is removably inserted through the lumen of the elongated shaft, the catheter having a tissue anchor assembly that is deployable from its distal end. In some embodiments, the handle includes a pin and track assembly that define a series of handle actuation steps corresponding to deployment steps for the deployment device end effector and the tissue anchor catheter. In some embodiments, the handle includes a catheter stop member that prevents movement of the tissue anchor catheter under certain circumstances, and a handle stop member that prevents actuation of the handle under certain circumstances. | 2009-12-17 |
| 20090312604 | PORTABLE SIMPLIFIED IMAGE DISPLAY APPARATUS AND RECEIVING SYSTEM - A portable simplified image display apparatus and a receiving system are provided, which can sensuously know the state of received strength of radio signals transmitted from a body-insertable apparatus, in either case of before examination or during examination. A viewer ( | 2009-12-17 |
| 20090312605 | ERGONOMIC HANDLE AND ARTICULATING LAPAROSCOPIC TOOL - The present invention relates to a laparoscopic apparatus. The apparatus comprises a handle having a body portion, a top surface, opposite bottom surface, a proximal and distal end. The top surface of the base is contoured to compliment the natural curve of the palm. The apparatus further includes a shaft projecting from the distal end of the handle. The shaft has a proximal and distal end. A control sphere is located on the handle. The control sphere can be moved by one or more of a user's fingers to indicate direction. An end effector is located at the distal end of the shaft. The end effector is connected to the control sphere such that movements made to the control sphere control cause movement (articulation) of the end effector. | 2009-12-17 |
| 20090312606 | FLEXIBLE DEVICE SHAFT WITH ANGLED SPIRAL WRAP - Spiral-wound materials, spirals, and shafts made therefrom that have wraps with edges that may nest within one another are described. Such edges allow the spiral to achieve a smaller bending radius, meaning tighter turns and more flexibility due to the ability of adjacent wraps to nest within each other when the shaft is bent. Spirals having wraps with edges capable of nesting can be used in the medical field for devices that track anatomy, such as endoscopes, colonoscopes, catheters, and the like. | 2009-12-17 |
| 20090312607 | LIGHT SOURCE DEVICE, IMAGING APPARATUS AND ENDOSCOPE APPARATUS - A light source device includes a first light source | 2009-12-17 |
| 20090312608 | METHOD AND DEVICES OF IMAGING AND BIOPSY - Certain embodiments include an endoscope and methods for imaging using the endoscope. The endoscope may include an imaging channel and a tip positioned at one end of the imaging channel, the tip adapted to collect light from a field of view that extends 360° around at least a portion of the endoscope and to transmit the light to the imaging channel. Certain embodiments may also utilize various sensors, controllers and processing mechanisms to record and process images into a representation, move the endoscope in and out of the endometrial cavity, and to biopsy a portion of the endometrium. | 2009-12-17 |
| 20090312609 | LIGHT GUIDE FOR ENDOSCOPES - A light guide for endoscopes is constituted by a plurality of multimode optical fibers, of which at least a portion is bundled. The light guide propagates illuminating light beam that enters from a first end facet thereof to a second end facet thereof, to emit the illuminating light beam onto a portion to be observed. The light guide includes: a light input portion formed by the bundled plurality of multimode optical fibers; and a light output portion formed by the bundled plurality of multimode optical fibers. At least one of the light input portion and the light output portion is shaped in a tapered shape, while the number of multimode optical fibers at the light input portion and the light output portion are the same as that at other portions of the light guide. | 2009-12-17 |
| 20090312610 | Disposable Speculums Having Single-Sided Support and Operating Mechanism - The embodiments disclosed herein relate to disposable speculums, and more particularly to disposable vaginal speculums having single-sided support and operating mechanisms. In an embodiment, a speculum includes an upper member having an upper blade and a hinge assembly; a lower member having a handle and a lower blade, wherein a combined smoke channel light guide directs light from a light source in the handle to a distal end of the lower blade for smoke removal; and a linear support member having a proximal end, a distal end, and an elongated body therebetween, the linear support member vertically moveable within a track positioned in the lower member. | 2009-12-17 |
| 20090312611 | Surgical Access Methods For Use With Delicate Tissues - Surgical methods providing access to delicate tissue, such as brain tissue or breast tissue, through a transcutaneous incision. A method may include making an incision adjacent a region containing delicate tissue, and providing a surgical assembly having: a retractor having a hollow sleeve extending from a proximal end to a distal end, and an introducer having a proximal end installed within the hollow sleeve and a distal end extending beyond the distal retractor end. The surgical assembly is advanced into the region containing delicate tissue, and the distal introducer end gently displaces the delicate tissue as the surgical assembly is advanced to thereby avoid damage to the delicate tissue. The introducer is removed from the retractor to leave the distal retractor end at a surgical site located in the physical region containing delicate tissue. One or more surgical instruments are then used through the hollow sleeve. | 2009-12-17 |
| 20090312612 | METHOD, SYSTEM AND APPARATUS FOR MONITORING PATIENTS - A method, system and apparatus for monitoring a subject are disclosed. The subject is provided with a plurality of monitoring units including a fixed monitoring unit at a predetermined location and a mobile monitoring unit attached to the subject, wherein the fixed monitoring unit fails to have separate measurement elements attachable to the subject. First physiological data is acquired from the subject through the fixed monitoring unit and second physiological data through the mobile monitoring unit. A least one state index indicative of the state of the subject is produced based on first selected physiological data. The producing includes employing second selected physiological data to enhance the reliability of the at least one state index when both the first physiological data and the second physiological data are available from the subject, wherein the first selected physiological data belongs to one of the first and second physiological data and the second selected physiological data belongs to one of the first and second physiological data and fails to belong to the first selected physiological data. | 2009-12-17 |
| 20090312613 | NON-INVASIVELY MONITORING BLOOD PARAMETERS - An apparatus for monitoring vital sign parameters in a biological entity is disclosed. In an embodiment, the apparatus includes at least one light source for transmitting light through the biological entity and at least one photodetector for receiving light transmitted through the biological entity. At least one light source and at least one photodetector are configured to be positioned proximate the biological entity in a manner that does not significantly impede blood flow through the biological entity. A signal is generated in response to the transmittance or reflectance of light through the biological entity. The signal corresponds to at least one characteristic of the generally unimpeded blood flow through the biological entity. The apparatus also includes a control system configured to analyze the signal to determine vital sign parameters in the biological entity. A method for monitoring vital sign parameters in a biological entity is also provided. | 2009-12-17 |
| 20090312614 | Transdermal Analyte Sensor Assembly and Methods of Using the Same - A transdermal test sensor assembly adapted to determine an analyte concentration of a fluid sample is disclosed. The assembly comprises a sensor support including at least one reservoir adapted to hold a liquid. The assembly further comprises a test sensor being coupled to the sensor support. The test sensor forms at least one aperture therein. At least a portion of the at least one aperture is adjacent to the at least one reservoir. The assembly further comprises a hydrogel composition positioned on the test sensor. The hydrogel composition is linked to the at least one reservoir via the at least one aperture. | 2009-12-17 |
| 20090312615 | Device for Determining the Glucose Level in Body Tissue - The apparatus for the non-invasive glucose detection comprises an electrical detection device ( | 2009-12-17 |
| 20090312616 | Transmission Fluorometer - This disclosure relates generally to a system and method for noninvasive, non-destructive fluorescent measurement. More specifically, the disclosure provides a non-invasive metrology system and method to monitor levels of fluorescent chemicals in the blood. A major application for the invention is field-based non-invasive blood testing for micro-nutrient deficiency and diseases resulting from it, such as Iron deficient anemia. The invention may help reduce or eliminate the need for blood drawing, sending the sample to a blood lab and having to wait for a result. | 2009-12-17 |
| 20090312617 | NEEDLE INJECTION CATHETER - The needle injection catheter includes a delivery tube and at least one hypotube that fits slidably within the delivery tube. The hypotube has at least three hollow needle portions extending outwardly at its distal end. The needle portions curve outwardly and have ends shaped to penetrate tissue. At least one reference electrode is located on the delivery tube, spaced from the second end. At least one proximal electrode is located adjacent and spaced from the end of the needle portion. The proximal electrode is electrically connected to a first notification device. A microcircuit is electrically connected to the proximal electrode, the reference electrode and to a power supply. A distal electrode is located adjacent the end of the needle portion and electrically connected to the microcircuit. A tip electrode is located adjacent the second end of the delivery tube and electrically connected to a second notification device and the microcircuit. | 2009-12-17 |
