50th week of 2008 patent applcation highlights part 37 |
Patent application number | Title | Published |
20080305449 | Method of preparing a surface for attaching of an orthodontic device - A method of preparing a surface of a tooth for attachment of an orthodontic device on a lingual surface of a tooth includes the step that a material mass is applied on the tooth to fill out one or more irregularities on the inside of the tooth. Thereafter the material mass is allowed to become hard and is shaped to achieve a preferably flat attachment surface for an orthodontic bracket or similar device. | 2008-12-11 |
20080305450 | PLACEMENT JIG FOR AN ORTHODONTIC DEVICE - Described are orthodontic devices intended to be attached to a tooth and in particular to the positioning and handling of equipment intended to be fastened to the tooth. The orthodontic device includes a component adapted to be attached to a tooth and a placement jig. The placement jig is attached to the component at a connection so that the jig may be turned or twisted at the connection. The connection is adapted to be easily disconnected when the component is attached to the tooth. In another embodiment, an orthodontic device is provided with a holding stick which may aid in either positioning the orthodontic device or, in case of a self ligating bracket, opening a lid. The device is in particular useful for orthodontic devices to be placed at the lingual side of a tooth. | 2008-12-11 |
20080305451 | SYSTEM AND METHOD FOR DETECTING DEVIATIONS DURING THE COURSE OF AN ORTHODONTIC TREATMENT TO GRADUALLY REPOSITION TEETH - Method and system for detecting and correcting deviation during an orthodontic treatment plan is provided. The method includes the steps of receiving an un-segmented current teeth image representing a patient's teeth after an orthodontic treatment plan has begun and before the plan ends for the patient; matching a previously segmented teeth model with the current teeth image; and generating at least one corrective stage to define an intermediate tooth arrangement, wherein the at least one corrective stage repositions a digital teeth image so that a prescribed tooth arrangement of the previously segmented teeth model can be used. | 2008-12-11 |
20080305452 | SYSTEMS AND METHOD FOR MANAGEMENT AND DELIVERY OF ORTHODONTIC TREATMENT - The present invention provides systems and methods of managing delivery of an orthodontic treatment plan using treatment guidelines, instructions and appointment planning tools customized to the individual patient being treated. A method includes, e.g., generating a treatment plan for a patient, generating a customized set of treatment guidelines, providing the set of customized treatment guidelines to the practitioner; and providing a set of orthodontic appliances to the practitioner. | 2008-12-11 |
20080305453 | TREATMENT PROGRESS TRACKING AND RECALIBRATION - The present invention relates to systems and methods of developing and tracking delivery and patient progression through an orthodontic treatment plan. One method includes identifying deviations from an orthodontic treatment plan, including receiving a digital representation of an actual arrangement of a patient's teeth after an orthodontic treatment plan has begun for the patient and prior to completion of the orthodontic treatment plan. The method further includes comparing the actual arrangement to a pre-determined planned arrangement to determine if the actual arrangement substantially deviates from the planned arrangement, the comparing comprising matching teeth from a previously segmented model to a surface of an unsegmented representation of the actual arrangement; and calculating one or more positional differences between the actual and planned arrangements of at least some of the corresponding teeth. | 2008-12-11 |
20080305454 | TREATMENT PLANNING AND PROGRESS TRACKING SYSTEMS AND METHODS - The present invention provides systems and methods of managing planning and delivery of an orthodontic treatment using planning tools, treatment guidelines, instructions and appointment planning tools customized to the individual patient being treated, as well as tools and methods for tracking delivery and patient progression through an orthodontic treatment plan. | 2008-12-11 |
20080305455 | Power Transmission Device For Driving a Dental Handpiece - An elongated flexible power transmission cable couples an electric motor within a control unit with a dental handpiece. The handpiece has a rotatable tool used for performing dental work within a patient's mouth. The power transmission device comprises a generally flexible and elongated cover having a proximal attachment end, a distal attachment end and a longitudinal axis that extends between the proximal and distal attachment ends. The proximal attachment end is mountable to the control unit and the distal attachment end is mountable to the dental handpiece. A generally flexible and elongated driving cable is rotatably positioned within the cover. The driving cable is generally rotatable about the longitudinal axis and has a proximal end for coupling with the electric motor and a distal end for coupling with and driving the dental handpiece. The driving cable transmitting torque from the electric motor to the dental handpiece | 2008-12-11 |
20080305456 | Dental implant stabilizing device - A stabilizing device for holding a dental implant in place essentially during the period between a dental implantation surgery and the osseointegration of the implant after the surgery. The device includes an implant, a plate member and a fastener for securing the plate member to the implant after the plate member is placed over the mouth side of the maxillary bone. | 2008-12-11 |
20080305457 | Methods of Applying Dental Agents to Dental Surfaces and Polymer Compositions - A method of applying a dental agent to a dental surface, the method including: applying a retentive polymeric coating to a dental surface; and subsequently contacting the retentive polymeric coating with a loading composition that includes a dental agent, wherein the contacting occurs under conditions effective to incorporate the dental agent into the retentive polymeric coating for release over time. Also provided are polymers that include a hydrophobic segment, a hydrophilic segment, a quaternary amine segment, and an alkoxy silane crosslinkable segment; and polymers that include a hydrophobic segment, a hydrophilic segment, a silicon-containing macromer segment, and an alkoxy silane crosslinkable segment. | 2008-12-11 |
20080305458 | METHOD AND APPARATUS FOR COMBINING A NON RADIOGRAHPIC IMAGE WITH AN XRAY OR MRI IMAGE IN THREE DIMENSIONS TO OBTAIN ACCURACY OF AN INTRA ORAL SCAN AND ROOT POSITION - A method includes the steps of: generating a three dimensional intra-oral image of the crown of a tooth or crowns of a plurality of selected teeth; generating a three dimensional image of the root of the corresponding tooth or roots of the corresponding selected teeth; and compositing the three dimensional images of the crown(s) and root(s) of the tooth to produce a composite image. An apparatus comprises means for performing each the foregoing steps. A computer-readable storage medium includes instructions for controlling a computer system to perform each of the steps. | 2008-12-11 |
20080305459 | Method for Real time Cure Status Monitoring of Dental Resin - A method is disclosed for monitoring the curing status of a dental resin through the inherent fluorescence of the dental resin under a curing light. The method requires no sample preparation and is fast enough for real time cure monitoring. | 2008-12-11 |
20080305460 | TRAINING TECHNIQUE FOR LEARNING AGILE METHODOLOGY - A method of training team participants to learn XP practices for generating a required application for a customer includes selectively using a combination of numeric, alphanumeric and pictorial puzzles/brain teasers and a set of role play instructions upon the training team participants learning of theoretical aspects of Agile methodology practices. The method delivers twelve programming practice-requirement-skills of: Onsite Customer, Planning Game, Small Iterations, Simple Design, Metaphor, Re-factoring Metaphor-use, Pair-Programming, Collective ownership, Sustainable Pace, Coding Standards, and Testing and Continuous Integration. The learning kit through timed iterations assists in designing, testing and code-release conforming to coding standards. The learning kit assists in producing the required code for the customer within time constraints of several iteration steps which precede code generation. The participants work and learn in team pairs which can be rotated if necessary. | 2008-12-11 |
20080305461 | Multi-Sensory Teaching Kit and Method of Production - A multi-sensory teaching kit includes one or more edible items in symbolic shapes, a handbook including a glossary of meanings for the shapes, and a spiritual lesson. In some embodiments, a souvenir such as a jewelry bead is provided, with an optional text explaining the significance of the souvenir. A method of production of a multi-sensory teaching kit is provided, comprising, forming a cookie into a symbolic shape, writing a handbook including a glossary of meanings of the symbolic shapes, printing a lesson on a spiritual principle, optionally providing a souvenir, and optionally enclosing the cookie, handbook, lesson, and optional souvenir in a container. | 2008-12-11 |
20080305462 | METHOD FOR IDENTIFYING AND INSTRUCTING TOP LEVEL ATHLETES - A method and system is provided for screening and identifying athletes that have the highest potential within their chosen sport and providing a training and development environment for these athletes at the elite and super elite level of their respective sport. The system employs a nine part integrated system that is structured in a manner that assists in identifying those player that are the most able to benefit from intensive training to move them from a top-level athlete to an elite athlete. The steps generally include prescreening, athlete selection, pre-training/preparation, intensive training, progress monitoring, player family support and communication, cultural exposure, professional career placement and post career support and counseling. In this context, a comprehensive approach is provided for identifying talented athletes and providing a training and development environment for these athletes. | 2008-12-11 |
20080305463 | TRAINING SYSTEM, TRAINING DEVICE, AND PROGRAM RECORDING MEDIUM AND PLAYBACK CONTROL METHOD - Disclosed is a training system that enables a player to take a lesson with smooth and correct breathing and continuously take a lesson while overcoming frustration. Through Step S | 2008-12-11 |
20080305464 | Apparatus and method for the simulation of the adverse cardiovascular effects of dynamic hyperinflation - A resuscitation system for the administration of cardiopulmonary resuscitation of asthma patients, and for teaching the cardiopulmonary resuscitation of asthma patients to simulate the cardiovascular and gas exchange effects of dynamic hyperinflation and to train healthcare workers to detect the adverse cardiovascular effects of dynamic hyperinflation. | 2008-12-11 |
20080305465 | System and method for modeling atomic structures - A system and method of an atomic tile including an elemental symbol for a corresponding element and a dot representation of at least one valance electron of the corresponding element. The dot representation are proximate to corresponding edges of the octagonal shape. | 2008-12-11 |
20080305466 | METHOD FOR DEMONSTRATING DIFFERENCES IN ANTIOXIDANT FUNCTIONALITY AMONG COSMETIC PRODUCTS - A method is provided for communicating to consumers through a test protocol chemical functionality of commercially available cosmetics. The method is a proof of the promotional advertising. The steps include comparing two or more different commercially available cosmetic products which advertise antioxidant functionality, contacting each of the products with a test system reactive with antioxidants, and generating a perceivable change in color proportionate to concentration of the antioxidant in the product. The test is preserved in a tangible medium such as a video and then shown to consumers who might have potential purchase interest. | 2008-12-11 |
20080305467 | Generation Of Pulsating Pressure Waves, E.G. For Cell Lysis - The present invention relates to a method by which a controlled source of heat (preferably a laser | 2008-12-11 |
20080305468 | ASSAYS FOR PREIMPLANTATION FACTOR AND PREIMPLANTATION FACTOR PEPTIDES - The present invention relates to assay methods used for detecting the presence of PIF, and to PIF peptides identified using this assay. In particular, the present invention relates to flow cytometry assays for detecting PIF. It is based, at least in part, on the observation that flow cytometry using fluorescently labeled anti-lymphocyte and anti-platelet antibodies demonstrated an increase in rosette formation in the presence of PIF. It is further based on the observation that flow cytometry demonstrated that monoclonal antibody binding to CD2 decreased in the presence of PIF. The present invention further relates to PIF peptides which, when added to Jurkat cell cultures, have been observed to either (i) decrease binding of anti-CD2 antibody to Jurkat cells; (ii) increase expression of CD2 in Jurkat cells; or (iii) decrease Jurkat cell viability. In additional embodiments, the present invention provides for ELISA assays which detect PIF by determining the effect of a test sample on the binding of anti-CD2 antibody to a CD2 substrate. | 2008-12-11 |
20080305469 | Fluorimetric Determination of Analytes By An Intramolecular Quencher-Fluorophore Conjugate - A method and reagent for detecting the presence or amount of an analyte by a redox reaction and a fluorimetric determination, is disclosed. The reagent comprises a compound of the general formula Q-F as a redox indicator, wherein Q is a quencher group and F is a fluorophore group. The quencher group Q or/and the fluorophore group F can be reduced or oxidized, and the fluorescence can change depending on the reduction or oxidation. | 2008-12-11 |
20080305470 | Nucleic Acid Sequencing - A method for determining a target nucleic acid sequence, wherein the target nucleic acid sequence is comprised in a preparation comprising a non-target nucleic acid sequence, the target nucleic acid sequence and the non-target nucleic acid sequence each having a first region of common sequence upstream of a first region of dissimilar sequence upstream of a second region of dissimilar sequence, the method comprising:
| 2008-12-11 |
20080305471 | Optoelectronic device and method of fabricating the same - A modified isolated polypeptide comprising an amino acid sequence encoding a photocatalytic unit of a photosynthetic organism being capable of covalent attachment to a solid surface and having a photocatalytic activity when attached thereto is disclosed. | 2008-12-11 |
20080305472 | Method of detecting influenza bacillus, primer set for detection of influenza bacillus and kit for detection of influenza bacillus - The present invention provides a method of detecting | 2008-12-11 |
20080305473 | Propagation of primary cells - The present invention provides a method of propagating cells of interest obtained from a biological specimen by enriching the cells under conditions that maintain sufficient cell viability; and propagating the cells under conditions effective to allow cell viability, proliferation and integrity. | 2008-12-11 |
20080305474 | Method and Apparatus for Using SLC2A10 Genetic Polymorphisms for Determining Peripheral Vascular Disease in Patients with Type-2 Diabetes - Recent data indicate that a loss-of-function mutation of the SLC2A10 gene causes arterial tortuosity syndrome (ATS) via upregulation of the TGF-β pathway in the arterial wall, a mechanism possibly causing vascular changes associated with diabetes. It is determined that SLC2A10 (Solute carrier family 2, facilitated glucose transporter, member 10) genetic polymorphism is associated with peripheral vascular disease (PVD) in patients with type 2 diabetes. | 2008-12-11 |
20080305475 | MICROBIAL COMMUNITY ANALYSIS - The present invention provides a method which can enhance the precision of identification of bacterial species using a T-RFLP method and achieve, by itself, the identification of bacteria constituting a bacterial flora and the tracing of distribution changes thereof. The present invention provides a method for analyzing a bacterial community including: amplifying DNAs extracted from a bacterial community by PCR using 16S rRNA genes as templates and fluorescently labeled primers; cleaving the amplification products with a restriction enzyme to thereby obtain sample PCR fragments; electrophoresing the sample PCR fragments together with size standard PCR fragments; and comparing the mobilities thereof to thereby determine the sizes of the sample PCR fragments, wherein PCR fragments amplified by using, as a template, a 16S rRNA gene derived from a bacterium contained in the bacterial community to be analyzed are used as the size standards. | 2008-12-11 |
20080305476 | Immunoassay Methods - The invention relates to a method of detecting a disease state or disease susceptibility in a mammalian subject which comprises detecting an antibody in a test sample comprising a bodily fluid from said mammalian subject wherein said antibody is a biological marker of a disease state or disease susceptibility, the method comprising: (a) contacting said test sample with a plurality of different amounts of an antigen specific for said antibody, (b) detecting the amount of specific binding between said antibody and said antigen, (c) plotting or calculating a curve of the amount of said specific binding versus the amount of antigen for each amount of antigen used in step (a) and (d) determining the presence or absence of said disease state or disease susceptibility based upon the amount of specific binding between said antibody and said antigen at each different antigen concentration used. | 2008-12-11 |
20080305477 | Novel Iminecalixarene Derivatives and Aminocalixarene Derivatives, Method of Preparation Thereof, and Self-Assembled Monolayer Prepared by the Method, Fixing Method of Oligo-Dna By Using the Self-Assembled Monolayer, and Oligo-Dna Chip Prepared By the Method - The present invention relates to novel iminecalixarene derivatives, method of preparation thereof, and self-assembled monolayer prepared by the method, fixing method of oligo-DNA by using the self-assembled monolayer, and oligo-DNA chip prepared by the method. Also, the present invention relates to novel aminocalixarene derivatives, method of preparation thereof, and self-assembled monolayer prepared by the method, fixing method of oligo-DNA wherein the oligo-DNA is voluntarily fixed by molecular recognition on said self-assembled monolayer in a liquid phase, and oligo-DNA chip prepared by the method. | 2008-12-11 |
20080305478 | Processes Using Dual Specificity Oligonucleotide and Dual Specificity Oligonucleotide - The present invention relates to various processes by a template-dependent extension reaction using a dual specificity oligonucleotide and a dual specificity oligonucleotide composed of three different Tm portions therefor. Demonstrated in the present invention are the features of the dual specificity oligonucleotide, which are high hybridization specificity and mismatch tolerance. | 2008-12-11 |
20080305479 | DETECTION AND QUANTIFICATION OF BIOMOLECULES USING MASS SPECTROMETRY - The present invention is directed in part to a method for detecting a target nucleic acid using detector oligonucleotides detectable by mass spectrometry. This method uses the 5′ to 3′ nuclease activity of a nucleic acid polymerase to cleave annealed oligonucleotide probes from hybridized duplexes and release labels for detection by mass spectrometry. This process is easily incorporated into a PCR amplification assay. The method also includes embodiments directed to quantitative analysis of target nucleic acids. | 2008-12-11 |
20080305480 | NOVEL TUMOR MARKER - The present invention concerns a gene product largely homologous to the epithelial growth factor receptor (EGFR). It further refers to mRNA coding for such epithelial growth factor receptor. The present invention provides such an epithelial growth factor receptor which is characterized in that either exons 12 to 14 or exons 12 to 15 are deleted. These novel variants of the epithelial growth factor receptor can be used for a diagnosis, stratification, therapy guidance of a tumor or therapy guidance of tumor surgery. | 2008-12-11 |
20080305481 | SYSTEMS AND METHODS FOR MULTIPLEX ANALYSIS OF PCR IN REAL TIME - The present invention provides methods and systems for real-time measurements of PCR with multiplexing capability. Certain embodiments relate to methods and systems that use fluorescently encoded superparamagnetic microspheres for the immobilization of amplification products during the PCR process, and an imaging chamber of a measurement device that is also capable of controllable thermal cycling for assisting the PCR process. | 2008-12-11 |
20080305482 | METHODS AND COMPOSITIONS FOR NUCLEIC ACID AMPLIFICATION - Compositions that are used in nucleic acid amplification in vitro are disclosed, which include a target specific universal (TSU) promoter primer or promoter provider oligonucleotide that includes a target specific (TS) sequence that hybridizes specifically to a target sequence that is amplified and a universal (U) sequence that is introduced into the sequence that is amplified, by using a primer for the universal sequence. Methods of nucleic acid amplification in vitro are disclosed that use one or more TSU oligonucleotides to attached a U sequence to a target nucleic acid in a target capture step and then use a primer for a U sequence in subsequent amplification steps performed in substantially isothermal conditions to make amplification products that contain a U sequence that indicates the presence of the target nucleic acid in a sample. | 2008-12-11 |
20080305483 | BIALLELIC MARKERS DERIVED FROM GENOMIC REGIONS CARRYING GENES INVOLVED IN ARACHIDONIC ACID METABOLISM - The invention provides polynucleotides including biallelic markers derived from genes involved in arachidonic acid metabolism and from genomic regions flanking those genes. Primers hybridizing to regions flanking these biallelic markers are also provided. This invention also provides polynucleotides and methods suitable for genotyping a nucleic acid containing sample for one or more biallelic markers of the invention. Further, the invention provides methods to detect a statistical correlation between a biallelic marker allele and a phenotype and/or between a biallelic marker haplotype and a phenotype. | 2008-12-11 |
20080305484 | Genetic methods for speciating Campylobacter - Species-specific identification of | 2008-12-11 |
20080305485 | GENETIC MARKER FOR INCREASED RISK FOR OBESITY-RELATED DISORDERS - The present invention relates to methods of determining an increased risk of a subject to acquire a trait of an obesity disorder or an obesity disorder, with the method comprising determining the genetic sequence of at least one taste receptor gene in the subject and reviewing the test genetic sequence(s) for the presence of at least one risk allele associated with at least one taste receptor. The presence of at least one difference in the test genetic sequence(s) and the presence of a risk allele associated with the taste receptor(s) may indicate an increased risk of the subject acquiring a trait of an obesity disorder or an obesity disorder. | 2008-12-11 |
20080305486 | SIGNAL AMPLIFICATION USING CIRCULAR HAIRPIN PROBES - The present invention provides methods for detecting a target nucleic acid using a circular dual-hairpin probe that is formed upon the presence of the target nucleic acid. The detection methods find use in detecting the presence of antibody-antigen complexes and for detecting the binding of a ligand to its binding partner. Kits and reaction mixtures for performing the present methods are also provided. | 2008-12-11 |
20080305487 | PROBE, PROBE SET, PROBE CARRIER, AND TESTING METHOD - A probe, a set of probes, and a probe carrier on which the probe or the set of probes is immobilized, are provided for classification of fungus species. The probe or the set of probes is capable of collectively detecting fungus of the same species and distinguishingly detecting those fungus from fungus of other species. The probe is an oligonucleotide probe for detecting a pathogenic fungus DNA and includes at least one of base sequences of SEQ ID NOS. 1 to 3 and mutated sequences thereof. | 2008-12-11 |
20080305488 | PROBE, PROBE SET, PROBE CARRIER, AND TESTING METHOD - A probe, a set of probes, and a probe carrier on which the probe or the set of probes is immobilized, are provided for classification of fungus species. The probe or the set of probes is capable of collectively detecting fungus of the same species and distinguishingly detecting those fungus from fungus of other species. The probe is an oligonucleotide probe for detecting a pathogenic fungus DNA and includes at least one of base sequences of SEQ ID NOS. 1 to 3 and mutated sequences thereof. | 2008-12-11 |
20080305489 | NEAR-INFRARED DYES AS SURFACE ENHANCED RAMAN SCATTERING REPORTERS - Nanoparticles comprising surface-enhanced Raman scattering (SERS) reporter molecules of the formula A-Y and methods of their use are disclosed, wherein A is selected from the group consisting of: | 2008-12-11 |
20080305490 | AMPLIFICATION OF HUMAN MDM2 GENE IN HUMAN TUMORS - A human gene has been discovered which is genetically altered in human tumor cells. The genetic alteration is gene amplification and leads to a corresponding increase in gene products. Detecting that the gene, designated hMDM2, has become amplified or detecting increased expression of gene products is diagnostic of tumorigenesis. Human MD2 protein binds to human p53 and allows the cell to escape from p53-regulated growth. | 2008-12-11 |
20080305491 | MCM6 AND MCM7 MONOCLONAL ANTIBODIES AND METHODS FOR THEIR USE IN THE DETECTION OF CERVICAL DISEASE - Compositions and methods for diagnosing high-grade cervical disease in a patient sample are provided. The compositions include novel monoclonal antibodies, and variants and fragments thereof, that specifically bind to MCM6 or MCM7. Monoclonal antibodies having the binding characteristics of an MCM6 or MCM7 antibody of the invention are further provided. Hybridoma cell lines that produce an MCM6 or MCM7 monoclonal antibody of the invention are also disclosed herein. The compositions find use in practicing methods for diagnosing high-grade cervical disease comprising detecting overexpression of MCM6, MCM7, or both MCM6 and MCM7 in a cervical sample from a patient. Kits for practicing the methods of the invention are further provided. Polypeptides comprising the amino acid sequence for an MCM6 or an MCM7 epitope and methods of using these polypeptides in the production of antibodies are also encompassed by the present invention. | 2008-12-11 |
20080305492 | DETECTION OF GLEEVEC RESISTANCE - The present invention relates to isolated polypeptides which comprise an amino acid sequence consisting of a mutated functional Abl kinase domain, said mutated functional kinase domain being resistant to inhibition of its tyrosine kinase activity by N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-4-(4-methyl-piperazin-1-ylmethyl)-benzamide or a salt thereof, to the use of such polypeptides to screen for compounds which inhibit the tyrosine kinase activity of such polypeptides, to nucleic acid molecules encoding such polypeptides, to recombinant vectors and host cells comprising such nucleic acid molecules and to the use of such nucleic acid molecules in the production of such polypeptides for use in screening for compounds which inhibit the tyrosine kinase activity of such polypeptides. | 2008-12-11 |
20080305493 | Determining Cancer-Linked Genes and Therapeutic Targets Using Molecular Cytogenetic Methods - Methods for identifying antineoplastic agents by using their ability to modify expression of specific genes or the biological activity of polypeptides encoded by such genes, wherein said genes are located in specific chromosomal regions, called amplicons, or regions of interest, and the presence of such amplified regions within a cancerous cell, are disclosed. Also described are methods for diagnosing cancerous, or potentially cancerous, conditions using these methods. Also encompassed are methods involving determining the modulated expression of the genes in these regions of interest (ROIs), or amplicons, as pharmacodynamic/pharmacogenetic/surrogate markers and/or for patient profiling prior to accrual for clinical trials/treatments based on the identification of these genes as validated gene/drug targets in various cancer tissue types. | 2008-12-11 |
20080305494 | Chemokine Ccl18 as a Biomarker - The invention relates to a diagnostic tool, e.g. to the chemokine CCL | 2008-12-11 |
20080305495 | Methods for determining the redox status of proteins - A method for determining the redox status of a protein sample, the method comprising the steps of: a) contacting the sample with a first label adapted to bind to at least one reduced cysteine group therein; b) contacting the sample with a reducing agent to reduce at least one oxidized cysteine group therein; c) contacting the sample with a second label adapted to bind to any reduced cysteine groups produced in step (b); and d) determining the ratio of the signal from the first label to the signal from the second label wherein the ratio indicates the redox status. | 2008-12-11 |
20080305496 | Method for identifying a compound that modulates SIR2 protein activity - The present invention relates to a method for identifying compounds that modulate the activity of sirtuin deacetylase protein family members. Compounds of the invention are identified by designing or screening for a compound which binds to at least one amino acid residue of the newly identified nicotinamide inhibition and base exchange site of Sir2 and testing the compound for its ability to modulate the activity of the Sir2 protein. Compositions and methods for preventing or treating diseases or disorders associated with Sir2 are also provided. | 2008-12-11 |
20080305497 | Polymeric carriers for immunohistochemistry and in situ hybridization - Certain disclosed embodiments of the present invention concern the synthesis, derivatization, conjugation to immunoglobulins and signal amplification based on discrete, relatively short polymers having plural reactive functional groups that react with plural molecules of interest. Reactive functional groups, such as hydrazides, may be derivatized with a variety of detectable labels, particularly haptens. The remaining reactive functional groups may be conjugated directly to a specific binding molecule, such as to the oxidized carbohydrate of the Fc region of the antibody. Disclosed conjugates display large signal amplification as compared to those based on molecules derivatized with single haptens, and are useful for assay methods, particularly multiplexed assays. | 2008-12-11 |
20080305498 | Biomarkers for Use in Vessel Disorders - The present invention relate to a method of diagnosing a subject having a vessel disorder. More particularly, a biological sample is obtained from a subject suspected of having a vessel disorder. A protein profile is determined or measured in the sample using procedures described herein, for example, mass spectrometry or immunodetection. The protein profile from the subject is compared to a protein profile in a healthy control, wherein an alteration in the levels of a protein of the profile in the subject compared to the healthy control is indicative of a vessel disorder. | 2008-12-11 |
20080305499 | Anti-Synoviolin Antibody - The present invention relates to an antibody against synoviolin or a fragment thereof for providing a monoclonal antibody capable of recognizing a part of synoviolin, which monoclonal antibody is capable of inhibiting the auto-ubiquitination of synoviolin. | 2008-12-11 |
20080305500 | NOVEL CELL-BASED ASSAYS FOR IDENTIFYING ENHANCERS OR INHIBITORS OF T1R TASTE RECEPTORS (T1R2/T1R3 SWEET) AND UMAMI (T1R1/T1R3 UMAMI) TASTE RECEPTORS - This invention relates to improved assays for identifying modulators (enhancers or inhibitors) of sweet (T1R2/T1R3) and umami (T1R1/T1R3) taste receptors. These receptors may comprise the endogenous T1Rs e.g., from humans or rodents, or may comprise functional variants such as chimeric taste receptors comprising the extracellular portion of one T1R or a variant or fragment thereof, either T1R1 or T1R2, and the transmembrane portion of another T1R or a variant or fragment thereof, either T1R1 or T1R2, preferably associated with a T1R3 polypeptide and a suitable G protein. The subject assays preferably use endogenous taste or gastrointestinal cells which express T1R taste receptors or recombinant cell which express such T1Rs, for example mammalian cells or | 2008-12-11 |
20080305501 | Compositions and Methods for Modulating Rank Activities - The present invention provides methods for identifying agents capable of modulating RANK-mediated invention also provides pharmaceutical compositions and methods of using the same for treating osteoporosis or other diseases. The present invention is based on the functional and structural analysis of a novel RANK signaling motif that was found to play a distinct role in activating RANK-mediated intracellular signaling. This motif can be used to screen for RANK modulators. This motif for treating a variety of diseases that are caused by or associated with abnormal RANK expression or activities. | 2008-12-11 |
20080305502 | Method of Screening Baff Suppressor or Inhibitor - A method of screening a novel BAFF suppressor or inhibitor. More specifically speaking, a method which comprises adding a combination of TPA with ionomycin and/or an anti-CD3 antibody to a cultured human cell to thereby induce the production of BAFF by the cell; a method of screening a substance capable of suppressing the expression or activity of BAFF which comprises adding a test substance to a BAFF-production system prepared by adding a combination of TPA with ionomycin and/or an anti-CD3 antibody to a cultured human cell and measuring the expression amount and/or the activity of BAFF in the BAFF-production system; and a BAFF production inducer for a BAFF-producing cell which contains a combination of TPA with ionomycin and/or an anti-CD3 antibody. | 2008-12-11 |
20080305503 | Diagnostic Test - The invention provides a method of diagnosing | 2008-12-11 |
20080305504 | Compositions, methods, and kits for assaying complement activation - The present invention provides a fluorogenic composition for assaying complement activation that comprises a substrate for C3 convertase that is linked to a first fluorophore and a second fluorophore, wherein the fluorescence of the first and second fluorophores are mutually substantially quenched when the two fluorophores are present at a distance less than the characteristic distance for the two fluorophores. In one embodiment, the fluorescence of the first fluorophore is substantially quenched by the second fluorophore, and the second fluorophore emits heat upon quenching. The present invention also provides a method for assaying complement activation, wherein the method includes the steps of incubating a biological sample with a polymer to provide a polymeric biological sample, followed by incubating the polymeric biological sample with the fluorogenic composition, and measuring the fluorescence. The method may optionally include the step of measuring the optical properties of the biological sample prior to the incubation steps. The present invention further provides a kit for assaying complement activation that comprises the fluorogenic composition disclosed herein. | 2008-12-11 |
20080305505 | Method For Dissolution Testing of Pharmaceutical Products - The present invention relates to the field of dissolution measurement and, more particularly to methods for reproducible dissolution testing of pharmaceutical products such as allergen vaccines. | 2008-12-11 |
20080305506 | FLUORESCENT DYES FOR USE IN GLUCOSE SENSING - A novel class of compounds that includes HPTS-Cys-MA, and methods of making them are disclosed herein. The class of compounds including HPTS-Cys-MA are useful as fluorescent dyes for analyte detection. | 2008-12-11 |
20080305507 | METHODS AND COMPOSITIONS FOR ASSAYING HOMOCYSTEINE - This invention relates generally to the field of homocysteine detection. In particular, the invention provides a method for determining homocysteine presence or concentration in samples, which method comprises: contacting a sample containing or suspected of containing Hcy with a Hcy co-substrate and a Hcy converting enzyme in a Hcy conversion reaction to form a Hcy conversion product and a Hcy co-substrate conversion product; and assessing the Hcy co-substrate conversion product to determine the presence, absence and/or amount of the Hcy in the sample. The Hcy co-substrate conversion product may be assessed directly, or it may be assessed by further conversion of the Hcy co-substrate conversion product into another material by the action of one or more additional enzymes. A kit for assaying homocysteine based on the same principle is also provided. | 2008-12-11 |
20080305508 | Methods of screening for compounds that modulate TAFIa activity, compounds, and methods of using the compounds - Provided are methods of screening compounds for any aspirin-related activity other than TAFI inhibition, and also for non-inhibition of TAFI. Compounds identified by the screening methods can be used to treat, prevent or manage in a patient pain, fever, colon cancer, pancreatic cancer or an inflammatory, platelet aggregation, fibrinolytic or hemorrhagic disease or disorder. Also provided is a method of evaluating test compounds for TAFI inhibitory activity wherein the TAFI inhibitory activity of these test compounds is compared to the TAFI inhibitory activity of aspirin or its derivatives or metabolites. Further provided is a method of treating, preventing or managing in a patient, a hemorrhagic or thrombotic disease or disorder with high dose aspirin or aspirin derivatives or metabolites. Also contemplated is a method of treating, preventing or managing in a patient, pain, fever, colon cancer, pancreatic cancer or an inflammatory, platelet aggregation, fibrinolytic or hemorrhagic disease or disorder comprising administering aspirin or a derivative thereof or any other therapeutic having at least one desired therapeutic or prophylactic activity of aspirin to a patient in need thereof and administering to the patient a factor that promotes TAFIa activity, e.g. stabilized TAFIa, to ameliorate one or more adverse side effects of the therapeutic. Compounds identified by the methods of the invention are also provided. | 2008-12-11 |
20080305509 | FLUORESCENCE POLARIZATION ASSAYS FOR DETERMINING CLOSTRIDIAL TOXIN ACTIVITY - The present invention provides a method of determining the presence or activity of a clostridial toxin by (a) treating with a sample, under conditions suitable for clostridial toxin protease activity, a clostridial toxin substrate which includes a fluorophore; a bulking group; and a clostridial toxin recognition sequence containing a cleavage site that intervenes between the fluorophore and the bulking group; (b) exciting the fluorophore with plane polarized light; and (c) determining fluorescence polarization of the treated substrate relative to a control substrate, where a change in fluorescence polarization of the treated substrate as compared to fluorescence polarization of the control substrate is indicative of the presence or activity of the clostridial toxin. | 2008-12-11 |
20080305510 | FLUORESCENCE POLARIZATION ASSAYS FOR DETERMINING CLOSTRIDIAL TOXIN ACTIVITY - The present invention provides a method of determining the presence or activity of a clostridial toxin by (a) treating with a sample, under conditions suitable for clostridial toxin protease activity, a clostridial toxin substrate which includes a fluorophore; a bulking group; and a clostridial toxin recognition sequence containing a cleavage site that intervenes between the fluorophore and the bulking group; (b) exciting the fluorophore with plane polarized light; and (c) determining fluorescence polarization of the treated substrate relative to a control substrate, where a change in fluorescence polarization of the treated substrate as compared to fluorescence polarization of the control substrate is indicative of the presence or activity of the clostridial toxin. | 2008-12-11 |
20080305511 | Method for screening antioxidant using mutant bacteria and chlorophyllide, and antioxidant screened by the method - Disclosed is a method for screening an antioxidant using mutant bacteria and chlorophyllide, and an antioxidant screened by the same method. More specifically, provided is a method for easy screening of an antioxidant by monitoring growth profiles of specific mutant bacteria in filter discs or medium blocks containing chlorophyllide added thereto, and an antioxidant screened by the same method. | 2008-12-11 |
20080305512 | ASSAY FOR CARDIAC TROPONIN AUTOANTIBODIES - The invention provides among other things methods and kits based on assaying for cardiac troponin autoantibodies, either in conjunction with an assay for cardiac troponin and/or as an independent indicator of cardiac pathology, such as myocarditis, cardiomyopathy, and/or ischemic heart disease. Assay methods of the invention can be employed among other things to identify cardiac pathology, or risk thereof, in subjects who have an autoimmune disease or who are related to an individual with an autoimmune disease. In particular embodiments, the invention also provides a method of determining whether a subject having, or at risk for, a cardiac pathology is a candidate for immunosuppressive therapy or immunoabsorption therapy. The invention also provides kits and kit components that are useful for performing the methods of the invention. | 2008-12-11 |
20080305513 | METHOD OF MEASURING CANCER AGGRESSIVENESS AND DETECTION THEREOF - Erythrocyte sedimentation rate (“ESR”) determinations of a patient's blood that has been combined either with blood serum from pregnant mammals or with fetal embryonic serum yield measurable results correlating well with the presence of an on-going cancer. This cancer detection method is based on differential ESR determinations and uses paired in vitro ESR tests, in which a patient's whole blood is combined with a control serum (in a control vial) comprising serum from non-pregnant mammal and with a test serum (in a test vial) comprising either fetal embryonic serum or serum from a pregnant mammal to measure differential ESR in the tested control vials. Cancer coefficient K is calculated based on the ESR measurements and is compared with a threshold value to determine whether the patient may be identified as possibly having an on-going malignancy. A kit for performing the cancer screening methodology is also provided. | 2008-12-11 |
20080305514 | METHOD FOR DETECTING MICROBES - The present invention relates to methods for detecting microbes in a sample comprising filtering the sample through a fluid-permeable surface, contacting the surface with a viability stain, scanning the surface for viability stain to form a first scan, contacting the surface with a nucleic acid stain, scanning the surface for nucleic acid stain to form a second scan, and comparing said first scan and said second scan. | 2008-12-11 |
20080305515 | Pathology Sample Processing Workstation - A pathology sample processing workstation. The samples are positioned on containers having RFID tags and processed at stations having RFID transceivers coupled to a computer. Information regarding the samples can stored on the RFID tags and retrieved using the transceivers. | 2008-12-11 |
20080305516 | Method of Producing Antibodies - Methods for producing immunoglobulin molecules or immunologically functional immunoglobulin fragments, the fragments comprising at least functional portions of the variable domains of immunoglobulin heavy and light chains, are described. The methods comprise producing the heavy and the light chains in two separate host cells and refolding the immunoglobulin molecule or fragment ex vivo. | 2008-12-11 |
20080305517 | Transglutaminase Crosslinked Collagen Biomaterial for Medical Implant Materials - The present invention provides a method for producing an improved biomaterial comprising treating a collagen biomaterial with a transglutaminase under conditions which permit the formation of cross-links within the collagen. Preferably, the transglutaminase is a tissue transglutaminase, a plasma transglutaminase or a microbial transglutaminase. In a preferred embodiment, the collagen biomaterial further comprises a cell adhesion factor, such as fibronectin. The invention further provides biomaterials obtainable by the methods of the invention, and medical implants and wound dressings comprising the same. | 2008-12-11 |
20080305518 | O-Linked Glycoforms Of Polypeptides And Method To Manufacture Them - The present invention relates to compositions comprising glycoproteins having altered patterns of O-linked glycosylation, in particular Factor VII, Factor IX, and methods for making these. | 2008-12-11 |
20080305519 | Biochemical method for specific protein labeling - An improved method for protein labeling comprising the steps of providing a synthetic small molecule tag, providing a target protein to be tagged, providing at least two enzymes for catalyzing a conjugation reaction between the tag and the target protein, incubating the tag, the protein and the enzyme, and allowing the tag to conjugate to the target protein. The tag may embody at least one structural feature of an ubiquitin C-terminus, and the structural feature may comprise a recognition sequence that is recognizable by an ubiquitin activating enzyme. | 2008-12-11 |
20080305520 | Mechanosensitive ion channels and methods of use - The present invention provides methods for identifying agents that decrease the activity of a mechanosenitive ion channels, preferably, a mechanosensitive Ca | 2008-12-11 |
20080305521 | Method for Overproducing Specific Recombinant Protein with P. Cinnabarinus Monokaryotic Strains - The use of monokaryotic strains of filamentous fungi of the | 2008-12-11 |
20080305522 | Novel Taste-Modifying Polypeptide Nas, Dna Thereof and Use Thereof - It is an object of the invention to find a substance with a better taste-modifying function and determine the structure of the taste-modifying substance, as well as to elucidate the structure thereof at a gene level and determine the primary structure of the substance and obtain the gene encoding the substance. Additionally, it is an object of the invention to provide a novel taste-modifying composition characteristically containing the taste-modifying substance. | 2008-12-11 |
20080305523 | Fungal Promoter for Expressing a Gene in a Fungal Cell - The present invention relates to isolated fungal promoter DNA sequences, to DNA constructs, vectors, and fungal host cells comprising these promoters in operative association with coding sequences encoding polypeptides. The present invention also relates to methods for expressing a gene and/or producing a polypeptide using the new promoters isolated. The present invention also relates to methods for altering the transcription level and/or regulation of an endogenous gene using the new promoter of the invention. | 2008-12-11 |
20080305524 | Molecular Glue - The present invention relates to an adhesive material being composed and/or consisting of at least one protein obtained or obtainable from flagella from archaea. Furthermore, the present invention relates to the use of at least one protein obtained from flagella from archaea for the method for the preparation of an adhesive material comprising the step of isolating and/or purifying at least one protein obtained from flagella from archaea. | 2008-12-11 |
20080305525 | Novel Hansenula Polymorpha Gene Coding for Alpha 1,6-Mannosyltransferase and Process for the Production of Recombinant Glycoproteins with Hansenula Polymorpha Mutant Strain Deficient in the Same Gene - Disclosed are a novel | 2008-12-11 |
20080305526 | Melibiose Operon Expression System - New vectors expressible in a host comprising the promoter region of the melibiose operon operably linked to a transcriptional unit that includes nucleic acid sequence which is heterologous to the host. The expression of the nucleic acid sequence is controlled by the promoter region of the melibiose operon. The new vector can be used for the regulated heterologous expression of a nucleic acid sequence in a prokaryotic host. There is an isolated and purified nucleic acid sequence expressible in a host comprising the promoter region of the melibiose operon operably linked to a transcriptional unit that includes a nucleic acid sequence which is heterologous to the host. The expression of the nucleic acid sequence is controlled by the promoter region of the melibiose operon. A prokaryotic host is transformed with the vector or the isolated and purified nucleic acid sequence. There is a method for producing a polypeptide in a host using the vector. | 2008-12-11 |
20080305527 | Single Chain Pan ECTO-NOX Variable Region (ScFv) Antibody, Coding Sequence and Methods - The present Specification describes compositions and methods for production of a recombinant single chain variable region (ScFv) antibody useful for the detection of members of the ECTO-NOX family of cell surface proteins on Western blots. This single chain antibody is especially useful in the detection, diagnosis and monitoring of neoplastic disorders. A linker sequence required to appropriately combine the light and heavy chain variable region fragments to form the functional recombinant single chain antibodies is also provided. The resultant ScFv is a pan ECTO-NOX antibody for detection on Western blots of most if not all tNOX isoforms. | 2008-12-11 |
20080305528 | ISOLATION OF NUCLEIC ACIDS - A method for extracting nucleic acids from a biological material such as blood comprises contacting the mixture with a material at a pH such that the material is positively charged and will bind negatively charged nucleic acids and then eluting the nucleic acids at a pH when the said materials possess a neutral or negative charge to release the nucleic acids. The nucleic acids can be removed under mildly alkaline conditions to the maintain integrity of the nucleic acids and to allow retrieval of the nucleic acids in reagents that are immediately compatible with either storage or analytical testing. | 2008-12-11 |
20080305529 | Glucose Isomerase Mutants, Dna Thereof and Use Thereof - This invention provides a series of recombinant | 2008-12-11 |
20080305530 | Method for Producing (R)-and (S)-4-(1-Ammoniumethyl)Benzoic Acid Methylester-Sulphate from Racemic 4-(1-Aminoethyl)Benzoic Acid Methylester by Lipase Catalysed Enantoselective Acylation and Subsequent Precipitation with Sulphuric Acid - A method for preparing optically active methyl 4-(1-ammoniumethyl)benzoate sulfate by reacting racemic methyl 4-(1-aminoethyl)benzoate with an acylating agent in the presence of a lipase to give methyl 4-(1-aminoethyl)benzoate and subsequently precipitating methyl 4-(1-ammoniumethyl)benzoate sulfate by adding sulfuric acid. | 2008-12-11 |
20080305531 | Compositions and Methods for Making and Modifying Oils - The invention provides novel methods for making or modifying oils, e.g., plant, animal or microbial oils, such as vegetable oils or related compounds, that are low in a particular fatty acid(s), for example, low linoleic oils, low linolenic oils, low palmitic oils, low stearic oils or oils low in a combination thereof. | 2008-12-11 |
20080305532 | Gene For Coenzyme Pqq Synthesis Protein B From Gluconobacter Oxydans - The present invention relates to a newly identified gene that encodes a protein that is involved in the synthesis of L-ascorbic acid (hereinafter also referred to a Vitamin C). The protein is coenzyme PQQ synthesis protein B. The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. The present invention also relates to the use of said polynucleotides and polypeptides as biotechnological tools in the production of Vitamin C from microorganisms, whereby a modification of said polynucleotides and/or encoded polypeptides has a direct or indirect impact on yield, production, and/or efficiency of production of the fermentation product in said microorganism. Also included are methods/processes of using the polynucleotides and modified polynucleotide sequences to transform host microorganisms. The invention also relates to genetically engineered microorganisms and their use for the direct production of Vitamin C. | 2008-12-11 |
20080305533 | Recombinant Microorganisms For Increased Production of Organic Acids - Disclosed are recombinant microorganisms for producing organic acids. The recombinant microorganisms express a polypeptide that has the enzymatic activity of an enzyme that is utilized in the pentose phosphate cycle. The recombinant microorganism may include recombinant | 2008-12-11 |
20080305534 | Novel Glycerol Dehydrogenase, Gene Therefor, and Method of Utilizing the Same - The present invention provides a polypeptide having physicochemical characteristics of (1) to (5) described below:
| 2008-12-11 |
20080305535 | In vitro amplification of nucleic acid molecules via circular replicons - Methods and compositions suitable for accomplishing the in vitro amplification of nucleic acid molecules via enzymatic means are provided. The preferred means employ circular rather than linear replicons. Means for producing such circular replicons from linear reactants are also provided. | 2008-12-11 |
20080305536 | Method for Culturing Microorganisms - The present invention is a method for the production of thermophilic microorganisms suitable for the production of ethanol, comprising: (i) culturing a thermophilic microorganism under aerobic or anaerobic conditions in a suitable culture media; and (ii) incorporating amounts of ethanol into the culture media to induce ethanol tolerance. | 2008-12-11 |
20080305537 | Microchips and its Manufacturing Methods Thereof - A microchip is provided with a lower substrate configured as the lower portion of the microchip, an intermediate section formed on the top of the lower substrate, and an upper substrate formed on the top of the intermediate section, wherein the lower substrate, the intermediate section, and the upper substrate are made of light-transmissive and cured resin. | 2008-12-11 |
20080305538 | Rapid and Sensitive Detection of Bacteria in Blood Products, Urine, and Other Fluids - The invention provides methods of detecting bacteria in fluids, including blood, platelets and other blood products for transfusion, and urine. The methods are based on lysing the bacteria to release ATP and detecting the ATP. Eukaryotic cell contamination is a problem to be overcome, because eukaryotic cell contain large amounts of ATP. Thus, some of the methods involve separating intact eukaryotic cells (e.g., platelets) from intact bacterial cells before lysing the bacterial cells to release ATP, contacting the ATP with an ATP-consuming enzyme that catalyzes a reaction, and monitoring the enzyme-catalyzed reaction. Typically, the enzyme is luciferin, and the reaction is monitored by detecting light produced by the luciferin. Other methods of the invention involve contacting a fluid sample with a support surface that binds bacterial cells, lysing the bacterial cells to release ATP, contacting the ATP with an ATP-consuming enzyme, and monitoring the enzyme-catalyzed reaction. Apparatuses for carrying out the methods are also disclosed. | 2008-12-11 |
20080305539 | MEMBRANE SUPPORTED BIOREACTOR FOR CONVERSION OF SYNGAS COMPONENTS TO LIQUID PRODUCTS - Ethanol and other liquid products are produced by contacting syngas components such as CO or a mixture of CO | 2008-12-11 |
20080305540 | MEMBRANE SUPPORTED BIOREACTOR FOR CONVERSION OF SYNGAS COMPONENTS TO LIQUID PRODUCTS - Ethanol and other liquid products are produced by contacting syngas components such as CO or a mixture of CO | 2008-12-11 |
20080305541 | Recombinant vectors for use in position-independent transgene expression within chromatin - The embodiments of the present invention are directed to discrete, cis-acting regulatory elements that include a barrier element, an insulating element, a silencing element, and matrix attachment regions (“MARs”). Additional embodiments of the present invention are directed to nucleic acid molecules that are useful for facilitating stable transgene expression within a chromatin environment. Additional embodiments of the present invention are directed to recombinant expression vectors including nucleic acid molecules of the present invention that can be incorporated into artificial chromosomes, eukaryotic cell-lines, non-human transgenic animals, and transgenic plants, to improve recombinant protein production in a broad range of eukaryotic hosts, and pharmaceutical compositions including nucleic acid molecules of the present invention that are also useful for gene therapy in the treatment of various genetic diseases. | 2008-12-11 |
20080305542 | HUMAN T2R61 TASTE RECEPTOR FOR IDENTIFYING HUMAN BITTER TASTE MODULATORS - The claimed invention relates to the discovery of a specific human taste receptor in the T2R taste receptor family, hT2R61 that responds to particular bitter compounds The present invention further relates to the use of this receptor in assays for identifying ligands that modulate the activation of this taste receptor. These compounds may be used as additives and/or removed from foods, beverages and medicinals in order to modify (block) T2R-associated bitter taste. A preferred embodiment is the use of the identified compounds as additives in foods, beverages and medicinals for blocking bitter taste. | 2008-12-11 |
20080305543 | RNA interference pathway genes as tools for targeted genetic interference - Genes involved in double-stranded RNA interference (RNAi pathway genes) are identified and used to investigate the RNAi pathway. The genes and their products are also useful for modulating RNAi pathway activity. | 2008-12-11 |
20080305544 | Method of Producing Nerve Cell - An Object of the present invention is to provide a process for producing a nerve cell by inducing differentiation of an embryonic stem cell, a method for inducing differentiation of the embryonic stem cell into a nerve cell, a medium to be used in the production process or differentiation induction method, or a method for improving purity of the nerve cell obtained by inducing differentiation of the embryonic stem cell. The present invention provides a process for producing a nerve cell which is applicable to treatment of neurodegenerative disease or the like easily, selectively or inexpensively by inducing differentiation induction of an embryonic stem cell using vitamin B | 2008-12-11 |
20080305545 | Shape memory thermoplastics and polymer networks for tissue engineering - Methods and compositions are described herein for reconstruction of different functional tissues. Dissociated cells, differentiated cells, adult mesenchymal stem cells or embryonic stem cells are seeded on a scaffold. The scaffold will consist of a biocompatible, biodegradable shape memory (“SM”) polymers. In addition bioactive substances may be incorporated in the scaffold. Thermoplastic as well as thermoset materials with SM-effect can be used. The shape memory effect will be applied as an interactive link between the cells and the used polymeric scaffold. The degradation kinetics as well as shape memory transition temperature will be tailored by adjusting to monomer ratios of the co-oligomers. The shape memory effect will be used to create a degradation or release of bioactive substances on demand, induce forces on seeded cells or induce proliferation and differentiation of cells. | 2008-12-11 |
20080305546 | Method for cultivating tendon cells from pluripotent cells of mesenchymal origin - A method for cultivating tendon cells from non-embryonic pluripotent cells of mesenchymal origin is described, wherein the isolated cells are cultivated in a culture medium under standard culture conditions in a culture vessel. In order to increase the collagen secretion, it is proposed that before their complete confluence, the cells are on the one hand further cultivated in a culture medium mixed with ascorbic acid and/or ascorbic acid-2-phosphate in a concentration of 25 to 75 μg/ml and on the other hand, subjected to hyperosmolar treatment in a culture medium whose osmolarity is adjusted to 350 to 500 mosmol/l. | 2008-12-11 |
20080305547 | Method for enhanced functional expression of cell receptors - The invention relates to methods for enhancing functional expression of receptor molecules in recombinant cells, preferably heterologous cells. In the method, a eukaryotic cell is transformed or transfected with all of the nucleic acid molecule which encodes the receptor, one which encodes a GEF, such as Ric-8A or Ric-8B, and one which encodes Gαolf. The resulting, recombinant cells are then contacted with an agent that stimulates the functional expression of the receptor. Preferably, the receptor is an odorant receptor, or “OR,” and the agent is a ligand for that OR. | 2008-12-11 |
20080305548 | METHOD FOR STIMULATING SALIVA PRODUCTION DURING ORAL SAMPLE COLLECTION PROCEDURE - A method and device are provided for stimulating and increasing the production of saliva during immunoassay tests for drugs or other analytes wherein a scent or odor capable of stimulating saliva production is incorporated into a device for obtaining an oral sample from a test subject. The scent or odor may be impregnated into the oral sample collection device or may be part of an attachment to such a device, and the scent or odor is disposed in such a manner so as to maximize the exposure of the scent to the test subject and thus stimulate the production of saliva. The method and device of the invention are advantageous because the increased production of saliva will facilitate the testing of an oral sample for drugs or other analytes and will increase the likelihood of obtaining a complete and accurate result. | 2008-12-11 |