50th week of 2009 patent applcation highlights part 56 |
Patent application number | Title | Published |
20090306320 | PHOTOCURING COMPOSITION AND CURED PRODUCT THEREOF - A photocuring composition, comprising a photoradically polymerizable compound and an ionically polymerizable compound having a surface energy smaller than that of the photoradically polymerizable compound, and a method of producing a cured product by using the composition thereof. | 2009-12-10 |
20090306321 | Non-Birefringent Optical Resin Material and Optical Member - Provided are an optical resin and an optical member using the same, both orientation birefringence and photoelasticity birefringence of the optical material being deadened and generally eliminated. The optical material consists of a composite constituent system of three or more constituents including a copolymerization system of monomer-element number not smaller than two, combination and constituent ratio of the composite constituent system being set so that both orientation birefringence and photoelasticity birefringence of the optical material are deadened at the same time and 5.0×10 | 2009-12-10 |
20090306322 | FORMING DIE AND MICROLENS FORMED BY USING THE SAME - The present invention provides a forming die having a mold releasing layer formed on a die surface of the forming die, the mold releasing layer containing a fluororesin and having a film thickness of 10 to 500 nm; a production process of a microlens including forming a resin by using the forming die; and a microlens produced by the production process. The forming die is capable of transferring a precise shape of a die surface of the forming die to optical parts as designed. | 2009-12-10 |
20090306323 | POLYOLEFIN FILM - A film of an ethylene polymer. | 2009-12-10 |
20090306324 | Polyethylene molding compositions for injection molding applications - Monomodal molding compositions based on polymers of ethylene, wherein the density of the molding compositions is in the range from 0.940 to 0.96 g/cm | 2009-12-10 |
20090306325 | POLYURETHANE DERIVATIVE, PROCESS FOR PRODUCING THE SAME AND BIOCOMPATIBLE MATERIAL COMPRISING THE SAME - A novel polyurethane derivative which is thermoplastic and excellent in thermoformability to a film or a tube and a process for producing the same are provided. Further, a biocompatible material with less blood platelet adhesion is provided. A linear oligosaccharide- or an acylated linear oligosaccharide-containing polyurethane derivative, and a process for producing a linear oligosaccharide-containing polyurethane obtained by reacting a linear oligosaccharide and a diol compound with a diisothiocyanate compound, and a process for producing an acylated linear oligosaccharide-containing polyurethane obtained by acylating the linear oligosaccharide-containing polyurethane. The biocompatible material characterized by using the linear oligosaccharide-containing polyurethane. | 2009-12-10 |
20090306326 | STABLE ETHYLPOLYSILICATES WITH GREATER THAN FIFTY PERCENT AVAILABLE SiO2 AND METHODS FOR MAKING THE SAME - A stable MQ resin solution with over 50% SiO | 2009-12-10 |
20090306327 | Method of reducing stress relaxation in polymer articles and articles formed thereby - A method of improving the mechanical properties of polymers is described. The method involves heat treating the polymer at a temperature below the glass transition temperature in a wet or in a dry environment. Polymer articles capable of moisture uptake in humid environments, as well as polymer articles less susceptible to moisture uptake, have improved mechanical properties, particularly improved stress relaxation behavior and set properties, when treated in accord with the heat treatment method. | 2009-12-10 |
20090306328 | COPOLYMER FOR SEMICONDUCTOR LITHOGRAPHY AND PROCESS FOR PRODUCING THE SAME - To provide a copolymer for semiconductor lithography employed for forming a resist film as well as thin films such as an anti-reflection film, a gap-filling film, a top coating film, etc. which are formed on or under a resist film, these films being employed in semiconductor lithography, wherein the copolymer has excellent solubility in a solution of a thin film-forming composition and prevents generation of microparticles (e.g., microgel) and pattern defects, and to provide a method for producing the copolymer reliably on an industrial scale. | 2009-12-10 |
20090306329 | NOVEL ESTER GROUP-CONTAINING TETRACARBOXYLIC ACID DIANHYDRIDE, NOVEL POLYESTERIMIDE PRECURSOR DERIVED THEREFROM, AND POLYESTERIMIDE - Provided are a polyimide that demonstrates low coefficient of hygroscopic expansion and low water absorption coefficient when used as an insulation film, as well as an ester group-containing tetracarboxylic acid dianhydride expressed by the general formula below, and a novel polyesterimide precursor derived therefrom and polyesterimide, for use in the production of such polyimide: | 2009-12-10 |
20090306330 | Polyamide resin and hinged molded product - A polyamide resin comprising a dicarboxylic acid constitutional unit comprising an adipic acid unit and a diamine constitutional unit comprising a pentamethylenediamine unit and a hexamethylenediamine unit wherein a weight ratio of the pentamethylenediamine unit to the hexamethylenediamine unit being in the range of 95:5 to 60:40; a vibration-welded molded product having an excellent vibration welding strength, a hinged molded product and a binding band having an excellent low-temperature toughness, and a filament having an excellent transparency which are obtained from the polyamide resin; and a hinged molded product comprising a polyamide resin constituted of an adipic acid unit and a pentamethylenediamine unit. | 2009-12-10 |
20090306331 | PROCESS FOR INCREASING THE MOLECULAR WEIGHT OF A POLYAMIDE - Process for increasing the molecular weight of a polyamide comprising a first step, wherein the polyamide is contacted in countercurrent with a first stream comprising 15 to 100 wt. % H | 2009-12-10 |
20090306332 | PREPARATION OF CAST POLYAMIDES USING SPECIAL ACTIVATORS - The present invention relates to a system comprising
| 2009-12-10 |
20090306333 | BIFUNCTIONAL LACTIDE MONOMER DERIVATIVE AND POLYMERS AND MATERIALS PREPARED USING THE SAME - The invention described herein provides a novel lactide monomer derivative and process for preparing the lactide monomer derivative. The monomer derivative of the invention is bifunctional in nature, and can be employed a variety of efficient synthesis processes to prepare various polymers. Further, the bifunctional monomer derivative can be used to prepare various intermediate-stage compounds and polymers, which in turn can be used to synthesize other compounds, polymers, copolymers and composites. The lactide monomer derivative has a bifunctional norbornene spiro lactide structure, spiro[6-methyl-1,4-dioxane-2,5-dione-3,2′-bicyclo[2.2.1]hept[5]ene], and structure as follows: | 2009-12-10 |
20090306334 | POLYMERIZABLE COMPOSITION AND POLYTHIOCARBONATE POLYTHIOETHER - Disclosed is a polymerizable composition comprising Component (a): a polythiocarbonate polythiol, Component (b): an episulfide compound, and optionally Component (c): an organic compound having a functional group that is reactive to the episulfide compound. The polymerizable composition can be cured to provide a polythioether having excellent optical properties (a high refractive index and a high Abbe's number) as well as excellent mechanical properties (a high bending distortion and a high glass transition temperature) and thus exhibiting excellent properties as an optical material. | 2009-12-10 |
20090306335 | MULTIFUNCTIONAL DEGRADABLE NANOPARTICLES WITH CONTROL OVER SIZE AND FUNCTIONALITIES - In one aspect, the invention relates to polymers, crosslinked polymers, functionalized polymers, nanoparticles, and functionalized nanoparticles and methods of making and using same. In one aspect, the invention relates to degradable polymer and degradable nanoparticles. In one aspect, the invention relates to methods of preparing degradable nanoparticles and, more specifically, methods of controlling particle size during the preparation of degradable nanoparticles. In one aspect, the degradable nanoparticles are useful for complexing, delivering, and releasing payloads, including pharmaceutically active payloads. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 2009-12-10 |
20090306336 | Preparation and Use of Ultrahigh-Molecular-Weight Polycarbonates - The present invention relates to a process for preparation of polycarbonates with weight-average molar mass M | 2009-12-10 |
20090306337 | Pegylated, Extended Insulins - PEGylated, extended insulins are insulins which, compared with human insulin, has one or more extensions extended from the A1, B1, A21 and/or B30 position(s), said extension(s) consist(s) of amino acid residue(s) and wherein a PEG moiety, via a linker, is attached to one or more of the amino acid residues in the extension(s). PEG is polyethyleneglycol. Such PEGylated, extended insulins have higher bioavailability and a longer time-action profile than regulär insulin and are in particular suited for pulmonary administration and can, conveniently, be used to treat diabetes. | 2009-12-10 |
20090306338 | Stabilized GLP-1 Analogs - Polypeptide analogs of the invention that include a) a base amino acid sequence at least 80% identical to one of a GLP-1 fragment; and b) amino acid residues attached to the carboxy terminus of the base amino acid sequence, where the analogs have GLP-1-like activity of longer duration than native GLP-1 and/or the GLP-1 receptor has a greater affinity for the analogs than native GLP-1. Other polypeptide analogs of the invention include a) a base amino acid sequence at least 50% identical to a GLP-1 fragment in which the amino acid residue in the base amino acid sequence corresponding to the P′ | 2009-12-10 |
20090306339 | Preparation of Fine Particles - A process for the precipitation of an organic compound comprising mixing simultaneously introduced streams of a solution and a precipitation agent in a chamber using a mechanical stirrer in the presence of an amphiphilic polymer. The process may be operated in a continuous manner and is particularly useful for providing low solubility organic compounds (e.g. pharmaceuticals) in readily dispersible, nano-sized particulate form up to manufacturing scale. | 2009-12-10 |
20090306340 | METHOD FOR PURIFICATION OF OLIGOPEPTIDES - The present invention provides: a method for purifying an oligopeptide, which comprises a step of contacting a solution comprising the oligopeptide and a neutral amino acid with an ion exchange resin in an effective pH range; the method for purifying an oligopeptide, which comprises (a) a step of passing a solution comprising the oligopeptide and the neutral amino acid through a column packed with an ion exchange resin, and (b) a step of eluting the oligopeptide contacted with the ion exchange resin with an eluting solvent; the above method using a weakly acidic cation exchange resin; the above method using a weakly basic anion exchange resin, etc. | 2009-12-10 |
20090306341 | LC/MS Blends Containing Ionizing Additives - The invention relates to the preparation of a salt in acetonitrile, characterised in that the acid component of the salt is an organic acid which boils at less than 300° C. under normal pressure, the base component of the salt is a base which boils at less than 300° C. under normal pressure, an organic acid which boils at less than 300° C. under normal pressure is added in the quantity of up to 1 vol. %, in relation to the volume of acetonitrile, and the water content, that can be determined by Karl Fischer titration, is below 5%. | 2009-12-10 |
20090306342 | BINDING OF MOLECULES - A method of binding a target molecule from an analyte containing the target molecule in admixture with at least one non-target molecule, which method comprises exposing the analyte to a substrate comprising first and second surface binding components, wherein the first surface binding component has specific binding affinity with respect to the target molecule but is independently unable to provide effective binding of the target molecule to the substrate, wherein the second surface binding component has non-specific binding affinity with respect to the target molecule and is independently unable to provide effective specific binding of the target molecule to the substrate, and wherein the target molecule is immobilized on the substrate by the combined binding effect of the first and second surface binding components. | 2009-12-10 |
20090306343 | Affinity Ligands - Disclosed is an affinity matrix comprising a solid phase and an affinity ligand comprising peptide bonds coupled to this solid phase, wherein the affinity ligand comprising peptide bond is selected from the following group of ligands: a) peptides comprising the formula X | 2009-12-10 |
20090306344 | METHOD OF REDUCING THE VISCOSITY OF MUCUS - Disclosed is a pO157 plasmid-specified polypeptide found in | 2009-12-10 |
20090306345 | MULTIPLE MODIFIED DERIVATIVES OF GELATIN AND CROSSLINKED MATERIAL THEREOF - The disclosed is a kind of multiple modified derivatives of gelatin having not only the structure of formula (I) but also one of structures of formula (II), (III), and (IV) as well. Wherein, G refers to gelatin residue comprising type A, type B and the type of gene recombination; R | 2009-12-10 |
20090306346 | METHOD FOR SEPARATING PROTEINS FROM LIQUID MEDIA - The invention relates to a method for separating proteins from liquid media, comprising
| 2009-12-10 |
20090306347 | ANTIBODY PRODUCED USING OSTRICH AND METHOD FOR PRODUCTION THEREOF - Disclosed is an antibody produced using an ostrich. Also disclosed is a method for producing the antibody. By using an ostrich, it becomes possible to produce antibodies (particularly antibodies for medical use), which have been hardly produced by using the mammals such as the mouse and the rat, homogeneously in a single body, in large quantities and in a simple manner. The method can overcome a disadvantage of lot-to-lot variation which may occur in the production of polyclonal antibodies using other animals. | 2009-12-10 |
20090306348 | Antibody Formulation - The present invention provides formulations and methods for the stabilization of antibodies. In one embodiment, the invention provides the stabile formulation of antibodies that are prone to non-enzymatic fragmentation at the hinge region. In a further embodiment, the invention provides methods of stabilization of antibodies comprising lyophilizing an aqueous formulation of an antibody. The formulations can be lyophilized to stabilize the antibodies during processing and storage, and then the formulations can be reconstituted for pharmaceutical administration. In one embodiment, the present invention provides methods of stabilization of anti-VEGFR antibodies comprising lyophilizing an aqueous formulation of an anti-VEGFR antibody. The formulations can be lyophilized to stabilize the anti-VEGFR antibodies during processing and storage, and then the formulations can be reconstituted for pharmaceutical administration. | 2009-12-10 |
20090306349 | BINDING PARTNERS WITH IMMUNOGLOBULIN DOMAINS MODIFIED TO HAVE EXTENDED HALF-LIFE - A method for conjugation of glycosylated Fc-containing proteins is described. The method comprises carbamate chemistry performed and neutral pH or below and the resulting Fc-containing protein are expected to retain tertiary structure and therefore Fc-related bioactivity such as FcR binding, the ability to bind Clq, in addition to retaining ligand binding capabilities related to the incorporation of a ligand binding peptide or other polypeptide which has binding specificity. The method is exemplified using an erythropoietin-mimetic peptide fused to a human IgG1 antibody constant domain comprising a hinge, CH2 and CH3. | 2009-12-10 |
20090306350 | NEW PURIFICATION METHOD OF LACTOFERRIN - The invention relates to methods for purifying lactoferrin, stabilizing it in solution and improving its activity. In one embodiment of the present invention, it is provided methods for lactoferrin purification employing hydrophobic and/or hydrophilic adsorbent under specific conditions for maintaining or preserving lactoferrin protein stability. It is also provided a process to remove inhibitor of lactoferrin activity. | 2009-12-10 |
20090306351 | Wash Buffer And Method Of Using - A method for purifying a protein using Protein A chromatography comprising a) absorbing the protein to Protein A immobilized on a solid support; b) removing contaminants by washing the immobilized Protein A containing the absorbed protein with a buffer comprising one or more chaotropic agents in combination with one or more hydrophobic modifiers and having a pH of at least 7.0; and c) eluting the protein from the Protein A immobilized on the solid support. | 2009-12-10 |
20090306352 | Basic Protein Purification Tags from Thermophilic Bacteria - The invention is related to a method for purification of recombinant proteins using highly basic proteins from thermophilic bacteria as purification tags for use in a cation-exchange chromatography purification step. The basic proteins may be ribosomal proteins. The recombinant proteins are expressed in eukaryotic or prokaryotic host cells. The purification tag will typically have a pl above about 9 and comprise from about 15 to about 250 amino acid residues. | 2009-12-10 |
20090306353 | PROCESS FOR PRODUCING SOY PROTEIN - The present invention is to provide a method for obtaining more efficiently isolated-soy protein, which has excellent gelation properties and shows neither bitterness nor astringency characteristic to soybean, while reducing the amount of water used in a soy protein manufacturing plant and thus lessening burden on the environment owing to the reduction in discharged water. It is a method for producing isolated-soy protein, including: an acid-washing step of washing defatted soybeans with an aqueous medium in a region of pH 3.0 to 5.0 to extract and remove whey components; an extraction step of extracting protein from acid-washed soybean slurry obtained in the acid-washing step with an aqueous medium in a neutral to alkaline region and then removing an extraction residue; and an isolation step of separating the extract solution obtained in the extraction step into water and protein while holding it in the neutral to alkaline region. | 2009-12-10 |
20090306354 | EGGSHELL MEMBRANE SEPARATION METHOD - A method for processing unseparated egg shells is provided. The method includes placing the unseparated egg shells in a fluid tank containing a fluid mixture, applying cavitation to the fluid mixture to thereby assist in separating the egg shell membranes from the egg shells, and recovering the egg shell membranes. Preferably, the fluid mixture is recirculated to thereby provide for continuous processing of unseparated egg shells. The method may further include drying the egg shell membranes to produce dried egg shell membranes which may then be vacuum packaged for storage and/or transport. The dried egg shell membranes may then be subjected to an extraction process for extracting at least one type of polypeptide from the egg shell membranes. Collagen, hyaluronic acid, or amino acids of interest may be extracted from the egg shell membrane and purified for numerous uses. | 2009-12-10 |
20090306355 | Preparation of 3,3'-diamino-4,4'-azoxyfurazan, 3,3'-4,4'-azofurazan, and pressed articles - A method for preparing essentially pure 3,3′-diamino-4,4′-azoxyfurazan (“DAAF”) that involves reacting an aqueous solution that includes 3,4-diaminofurazan (“DAF”) with OXONE™ (i.e. 2KHSO | 2009-12-10 |
20090306356 | siRNA Targeting TNFalpha - Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed including those directed to TNFα. | 2009-12-10 |
20090306357 | COMPOUNDS AND METHODS FOR MODULATING EXPRESSION OF GCCR - The present disclosure describes short antisense compounds, including such compounds comprising chemically-modified high-affinity monomers 8-16 monomers in length. Certain such short antisense compound are useful for the reduction of target nucleic acids and/or proteins in cells, tissues, and animals with increased potency and improved therapeutic index. Thus, provided herein are short antisense compounds comprising high-affinity nucleotide modifications useful for reducing a target RNA in vivo. Such short antisense compounds are effective at lower doses than previously described antisense compounds, allowing for a reduction in toxicity and cost of treatment. In addition, the described short antisense compounds have greater potential for oral dosing. | 2009-12-10 |
20090306358 | SULFUR TRANSFER REAGENTS FOR OLIGONUCLEOTIDE SYNTHESIS - The use of N-formamidino-5-amino-3H-1,2,4-dithiazole-3-thiones as novel, efficient sulfur-transfer reagents is disclosed. The sulfur transfer from these reagents to compounds containing P(III) atom, triphenylphosphine, 5′-O-DMT-thymidine 2-cyanoethyl-(N,N-diisopropyl)phosphoramidite, and 5′-O-DMT-3′-O-levulinyl dithymidilyl 2-cyanoethyl phosphite, was studied in solution by | 2009-12-10 |
20090306359 | NON-ALCOHOLIC BUFFER FORMULATIONS FOR ISOLATING, PURIFYING AND RECOVERING LONG-CHAIN AND SHORT-CHAIN NUCLEIC ACIDS - Embodiments relate to methods and formulations of buffers used for isolating, purifying, and recovering long-chain and short-chain nucleic acids. The areas of application of the inventive method include all laboratories engaged in isolating nucleic acids. In one embodiment a solution containing a nucleic acid is prepared with additives containing monovalent and multivalent cations and, optionally, an alcohol and/or additional additives. The solution is contacted with a solid phase, the solid phase is optionally washed, and the nucleic acid is removed. The solution may contain multivalent and/or monovalent cations and may contain an alcohol. The solution in certain embodiments has a pH between 7 and 10. Ammonium chloride, sodium chloride and/or potassium chloride may be used as monovalent salt components. Magnesium chloride, calcium chloride, zinc chloride and/or manganese chloride may be used as multivalent salt components. In a preferred embodiment, identical molar amounts of sodium chloride and manganese chloride are used. | 2009-12-10 |
20090306360 | 2-AZAPURINE COMPOUNDS AND THEIR USE - Within oligonucleotides, 2-azapurine and especially 2-azaadenine bases form specifically base pairs with guanine. This base pair is of analogous stability as an adenine-thymine but less stable than a guanine-cytosine base pair. Therefore, the incorporation of 2-azaadenine residues into oligonucleotides instead of cytosine leads specifically to hybridization complexes with nucleic acids with homogenous stability. This is useful for the adaptation of the stabilities of different oligonucleotide sequences in all kinds of hybridization techniques, for example in oligomer chip technology. | 2009-12-10 |
20090306361 | PROCESS FOR PRODUCING CELLULOSE ESTER FILM, CELLULOSE ESTER FILM, POLARIZATION PLATE AND DISPLAY UNIT - A process for producing a cellulose ester film that is produced by a melt casting method using no solvent at film formation, and that attains reduction of bright spot foreign matter, excelling in planarity, and that attains reduction of staining, excelling in dimensional stability. It is also intended to provide such a cellulose ester film, a polarizing plate and a liquid crystal display unit. There is provided a process for producing a cellulose ester film, characterized by forming into a film a material containing a cellulose ester and an ester compound of 1 to 7.5 distribution coefficient obtained by condensation of a polyhydric alcohol and an organic acid of the general formula: (1) according to a melt casting method. | 2009-12-10 |
20090306362 | METHYL AQUOCOBYRINIC ACID DERIVATIVE, ALKYLATION COMPOSITION, AND METHOD FOR DETOXIFYING A HARMFUL COMPOUND BY UTILIZING THE COMPOSITION - The composition for the alkylation according to the present invention is characterized in that the composition contains a cobalt complex. The method of detoxifying the harmful compound according to the present invention, is characterized in that a harmful compound containing at least one element selected from the groups comprising arsenic, antimony and selenium is detoxified by the alkylation of the harmful compound, in the presence of the composition according to the present invention. | 2009-12-10 |
20090306363 | Preparation Method of Bioresorbable Oxidized Cellulose - Bioresorbable material made of oxidized natural or regenerated cellulose intended primarily for health care purposes is prepared in such a way that a solvent from the family of perfluoroethers or perfluoropolyethers with the boiling point between 50 and 110° C. is used for the oxidation by dinitrogen tetraoxide. | 2009-12-10 |
20090306364 | USE OF SPECIAL SCREENS IN THE PREPARATION OF CELLULOSE POWDER - The present invention refers to the use of screens comprising at least two layers of different mesh or pore size in a cellulose powder preparation method as well as to said method, wherein grinding the cellulose pulp and sieving the obtained particles can be carried out on-line. | 2009-12-10 |
20090306365 | Hydrogenolysis of Sugar Feedstock - A process for the hydrogenolysis of a sugar feedstock in the presence of a catalyst comprising: (a) ruthenium or osmium; and (b) an organic phosphine; and wherein the hydrogenolysis is carried out in the presence of water and at a temperature of greater than 150° C. | 2009-12-10 |
20090306366 | Manufacturing Method Of Tagatose Using Galactose Isomerization Of High Yield - The present invention relates to a manufacturing method of tagatose using galactose isomerization of high yield, more particularly a method to enhance conversion rate of isomerization by adding borate which binds specifically to tagatose and a manufacturing method of tagatose using the same. | 2009-12-10 |
20090306367 | PROCESS FOR PREPARING AMIDES FROM KETOXIMES - The present invention is directed to a process for preparing amides. In particular, the process is directed to a process performable on the industrial scale, in which a ketoxime can be converted to a cyclic or acyclic amide by means of a Beckmann rearrangement using 2,4,6-trichloro-1,3,5-triazine as a catalyst in a nonpolar organic solvent. | 2009-12-10 |
20090306368 | POLYNUCLEAR COMPLEX - A polynuclear complex having two or more metal atoms and/or metal ions per one ligand of the general formula (I): | 2009-12-10 |
20090306369 | PROCESS FOR PREPARING BENZAZEPINE COMPOUNDS OR SALTS THEREOF - This invention provides a process for preparing benzazepine compounds of the formula (1): wherein X | 2009-12-10 |
20090306370 | Method Of Manufacturing An Organic Silicon Compound That Contains A Methacryloxy Group Or An Acryloxy Group - A method of manufacturing an organic silicon compound that contains a methacryloxy group or an acryloxy group, the method being characterized by the fact that manufacturing or conducting purification by distillation is carried out in the presence of a phenothiazine derivative having a molecular weight equal to or higher than 240. And a stable composition comprising an organic silicon compound that contains a methacryloxy group or an acryloxy group and a phenothiazine derivative having a molecular weight equal to or higher than 240 and used in an amount sufficient to stabilize the aforementioned organic silicon compound. | 2009-12-10 |
20090306371 | CYANOPYRROLE CONTAINING CYCLIC CARBAMATE AND THIOCARBAMATE BIARYLS AND METHODS FOR PREPARING THE SAME - Methods for preparing cyclic carbamates and thiocarbamates containing cyanopyrrole moieties and of the formula are provided. | 2009-12-10 |
20090306372 | Process for Making 3-Substituted 2-Amino-5-Halobenzamides - Disclosed is a method for preparing a compound of Formula 1 by contacting compound of Formula 2 with R | 2009-12-10 |
20090306373 | 4,7-DIHYDROTHIENO[2,3-B]PYRIDINE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS - This invention relates generally to compounds and pharmaceutical compositions for the treatment of myosin heavy chain (MyHC)-mediated conditions, and in particular, cardiovascular conditions. | 2009-12-10 |
20090306374 | FUSED HETEROCYCLIC DERIVATIVE AND USE THEREOF - The present invention provides a fused heterocyclic derivative having a potent kinase inhibitory activity and use thereof. | 2009-12-10 |
20090306375 | Process for production of 4(3H)-quinazolinone derivative - The present invention provides a process for producing a 4(3H)-quinazolinone derivative, which is useful as a medicinal substance, with better efficiency in an industrial scale. The process comprises the steps of reacting 4-hydroxy-N-tert-butoxycarbonylpiperidine with 4-fluoro-1-nitrobenzene in the presence of sodium hydride, reacting the resulting product with cyclobutanone, reducing the resulting product to give 4-(1-cyclobutyl-4-piperidinyl)oxyaniline, and reacting this compound with 2-methyl-5-trifluoromethyl-4H-3,1-benzoxazin-4-one to give 3-{4-[(1-cyclobutyl-4-piperidinyl)oxy]phenyl}-2-methyl-5-trifluoromethyl-4(3H)-quinazolinone. | 2009-12-10 |
20090306376 | OPTICAL RECORDING MEDIUM AND COMPOUND USED FOR THE SAME - A compound comprising a ring structure including a ring composed of four carbon atoms and two nitrogen atoms and a substituted or unsubstituted amino group bonded to the ring structure. | 2009-12-10 |
20090306377 | NOVEL PROCESS FOR THE PREPARTION OF ERLOTINIB - The present invention discloses an improved and novel process for the preparation of erlotinib (N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine) of formula (1), which comprises: (i) demethylation of commercially available 6,7-dimethoxy-4(3H)-quinazolinone of formula (8); acetylation using acetic anhydride; (iii) introduction of a leaving group at C-4 position in quinazolinone; (iv) condensation with 3-ethynylaniline to get novel compound of formula (12); (v) deacetylation to get novel dihydroxy compound of formula (13); and (vi) O-alkylation with 2-iodoethylmethyl ether to get the erlotinib base of formula (1). Erlotinib base is purified by recrystallization from ethyl acetate to get a HPLC purity of >99.5%. Salt formation of this base with hydrogen chloride gave pharmaceutically acceptable erlotinib hydrochloride of formula (1 | 2009-12-10 |
20090306378 | PROCESS FOR PREPARING AMINOCROTONYLAMINO-SUBSTITUTED QUINAZOLINE DERIVATIVES - The invention relates to an improved process for preparing aminocrotonylamino-substituted quinazoline derivatives of general formula (I) wherein the groups R | 2009-12-10 |
20090306379 | POLYMORPHS OF BENZOATE SALT OF 2-[[6-[(3r)-3-AMINO-1- PIPERIDINYL]-3,4-DIHYDRO-3- METHYL-2,4-DIOXO-1(2H)-PYRIMIDINYL]METHYL]-BENZONITRILE AND METHODS OF USE THEREFORE - Compositions comprising Compound I, wherein the Compound I is present in one or more polymorphic forms. Also provided are kits and articles of manufacture with compositions comprising one or more polymorphs of Compound I, and methods of using the compositions to treat various diseases. | 2009-12-10 |
20090306380 | Process for preparing 4-amino-2-alkylthio-5-pyrimidinecarbaldehyde - Provided are a process for preparing a 4-amino-2-alkylthio-5-pyrimidinecarbaldehyde, which is industrially advantageous in that a 4-amino-2-alkylthio-5-pyrimidinecarbaldehyde can be prepared in high yield in a simple way, an intermediate used in the process, and a process for preparing the intermediate, which is industrially advantageous in that the intermediate can be prepared safely in high yield with ease. | 2009-12-10 |
20090306381 | Mono Amine and Diamine Derivatives of CL-20 - The invention describes the synthesis of novel mono-amine and di-amine derivatives of hexa-nitro-hexaazaisohex-awurtzitane (CL-20). The synthesis is effected by the novel use of fluoroacylating compounds to protect the secondary amine groups of acylated precursors to CL-20 against nitrolysis. In so doing the mono-amine and di-amine derivatives of CL-20 are rendered and which in turn may be subsequently utilised as intermediates to generate further novel derivatives with differing physical and chemical properties to the parent compound. Formula (I), wherein:— X═H, and Y═H or NO | 2009-12-10 |
20090306382 | CATIONIC ALKOXYAMINES - The instant invention relates to cationic alkoxyamines, which are useful as polymerization initiators/regulators in a controlled stable free radical polymerization process to produce intercalated and/or exfoliated nanoparticles from natural or synthetic clays, The invention also relates to improved nanocomposites produced by this process and to the use of these nanocomposite compositions as, for example, coatings, sealants, caulks, adhesives and as plastic additives. | 2009-12-10 |
20090306383 | Method for Producing 2-(4-Methyl-2-Phenylpiperazin-1-Yl)Pyridine-3-Methanol - The present invention provides a method for producing 2-(4-methyl-2-phenylpiperazin-1-yl)pyridine-3-methanol, and this method includes the step of catalytically reducing 2-(4-methyl-2-phenylpiperazin-1-yl)-3-cyanopyridine in the presence of a partially deactivated palladium catalyst in an aqueous acid solution. | 2009-12-10 |
20090306384 | Process for the Production of Benzopyran-2-ol Derivatives - The invention provides a process for producing a compound of formula (I), | 2009-12-10 |
20090306385 | REVERSIBLY REDUCIBLE METAL COMPLEXES AS ELECTRON TRANSPORTING MATERIALS FOR OLEDS - The invention is reversibly reducible metal complexes and materials and an organic light emitting device, having an anode; a cathode; and at least one organic layer disposed between the anode and the cathode, made with the complexes of the invention. The reversibly reducible metal complexes are complexes a redox active metal center and at least one ligand; wherein; following a reduction of the complex, adding 1 extra electron to the complex, the extra electron is localized on the metal center. The complexes may function as an ETL or a host material. | 2009-12-10 |
20090306386 | Plant Extract Obtained by an Extraction Method by Means of Solvents of Plant Origin - The invention relates to a plant extract obtained by a single-phase extraction method, by means of a solvent and/or a mixture of solvents of plant origin, containing characterised and chemically defined constituents. Said plant extract is characterised in that it is free of polyphenol, anthocyan and/or tannin, and comprises a fraction of lipophile-type components and/or a fraction of polar-type components. The invention also relates to an extraction method which enables an inventive extract to be obtained, said method being a single-phase extraction method characterised in that it comprises the following steps: a plant material is brought into contact with a solvent and/or a mixture of solvents of plant origin, containing characterised and chemically defined constituents; the plant material is eliminated; and the solvent and/or mixture of solvents is partially or completely eliminated. Said solvent and/or at least one of the constituents of the mixture of solvents is selected from the group of terpenic solvents having a purity which is at least equal to 98% and being depleted of peroxides. | 2009-12-10 |
20090306387 | METHOD OF MANUFACTURING OF 7-ETHYL-10-HYDROXYCAMPTOTHECIN - The method of manufacturing of 7-ethyl-10-hydroxycamptothecin of formula I characterized in that 7-ethyl-1,2,6,7-tetrahydrocampotothecin of formula IV is oxidized with an oxidizing agent selected from the group comprising iodosobenzene, an ester of iodosobenzene, sodium periodate, potassium periodate, potassium peroxodisulfate and ammonium peroxodisulfate, in a solvent formed by a saturated aliphatic monocarboxylic add containing 1 to 3 carbon atoms, and in the presence of water. | 2009-12-10 |
20090306388 | METHOD FOR SUBSTITUTED IH-IMIDAZO[4,5-C] PYRIDINES - Methods for preparing compounds of the Formulas IV and I are disclosed. The methods include combining a compound of the Formula II: with a benzylamine of the Formula III: in the presence of an acid to provide a 1H-imidazo[4,5-c]pyridine compound of the Formula IV. | 2009-12-10 |
20090306389 | Intermediate products for producing oxazolidinone-quinolone hybrids - The present invention describes intermediates (ZP) for a novel and efficient synthesis of compounds in which the pharmacophores of quinolone and oxazolidinone are linked to one another by way of a chemically stable linker. | 2009-12-10 |
20090306390 | CHIRAL LIGANDS, THEIR PREPARATION AND USES THEREOF IN ASYMMETRIC REACTIONS - A novel class of chiral ligands represented by a structure of Formula (I): wherein R | 2009-12-10 |
20090306391 | METHOD FOR DEPROTECTING ARYL OR ALKYL SULFONAMIDES OF PRIMARY OR SECONDARY AMINES - The invention relates to a method for removing an alkyl sulfonyl or aryl sulfonyl protecting group from a primary or secondary amine by contacting an alkyl sulfonamide or an aryl sulfonamide with a Stage 0 or Stage I alkali metal-silica gel material in the presence of a solid proton source under conditions sufficient to form the corresponding amine. The invention also relates to a method for removing an alkyl sulfonyl or aryl sulfonyl protecting group from a primary or secondary amine by a) reacting an alkyl sulfonamide or an aryl sulfonamide with a Stage 0 or Stage I alkali metal-silica gel material, and b) subsequently reacting the reaction product from step a) with an electrophile or a proton source. Preferred Stage 0 or Stage I alkali metal-silica gel materials include Na, K | 2009-12-10 |
20090306392 | GSM INTERMEDIATES - The present invention relates the use of compounds having the general Formula I, wherein the definitions or R | 2009-12-10 |
20090306393 | PROCESS FOR PREPARING OF, IMPURITIES FREE, SUBSTITUTED 2-BENZIMIDAZOLE-SULFOXIDE COMPOUND - The present invention relates to an improved process for the preparation of pantoprazole free from overoxidation impurities. The process enables better control of the process and therefore the quality of the products obtained, avoiding the formation of impurities. | 2009-12-10 |
20090306394 | Method for Producing Nanoparticles - The present invention provides a method for producing nanoparticles by attaching atoms or molecules constituting a nanoparticle precursor to an ionic liquid. According to this method, it is possible to produce nanoparticles that do not aggregate easily in a liquid without its surface modification. Furthermore, it is possible to produce nanoparticles without the need for a complicated operation or the formation of a by-product because of the direct production of the nanoparticles from the nanoparticle precursor. | 2009-12-10 |
20090306395 | METALLIC COMPOUND AND ORGANIC ELECTROLUMINESCENCE DEVICE COMPRISING THE SAME - The present invention relates to a light emitting transition metal compound of Chemical Formula 1 and an organic electroluminescence device including the compound. | 2009-12-10 |
20090306396 | NITROGENATED HETEROCYCLIC COMPOUND AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME - The present invention relates to novel compounds having a xanthine oxidase inhibitory effect and an uricosuric effect and pharmaceutical compositions comprising the same as an active ingredient. That is, the present invention relates nitrogen-containing heterocyclic compounds represented by the following general formula (I): | 2009-12-10 |
20090306397 | Method for the production of substituted azoles - The novel process for preparing substituted azoles allows compounds of the general formula (I) and/or their salts and/or their acid addition compounds | 2009-12-10 |
20090306398 | METHODS OF TREATING ALPHA ADRENERGIC MEDIATED CONDITIONS - Described herein are compounds for and methods of treating conditions or diseases in a subject by administering to the subject a pharmaceutical composition containing an effective amount of an α-adrenergic modulator. The compounds and methods are also useful for alleviating types of pain, both acute and chronic. | 2009-12-10 |
20090306399 | METHOD FOR PRODUCING 1-SUBSTITUTED-5-ACYLIMIDAZOLE COMPOUND - Disclosed is a commercially suitable method for producing a 1-substituted-5-acylimidazole compound. A 1-substituted-5-acylimidazole compound is produced with a high position selectivity by reacting an N-substituted amidine compound or a salt thereof with a ketone compound in the presence of a base. | 2009-12-10 |
20090306400 | CONVERGENT PROCESS FOR THE SYNTHESIS OF TAXANE DERIVATIVES. - The present invention is broadly directed to novel compounds useful for the synthesis of biologically active compounds, including taxane derivatives, and convergent processes for the preparation of these taxane derivatives and their intermediates. | 2009-12-10 |
20090306401 | Method For The Production of 5-Fluoro-1,3-Dialkyl-1H-Pyrazol-4-Carbonyl Fluorides - The present invention relates to a novel process for preparing known 5-fluoro-1,3-dialkyl-1H-pyrazole-4-carbonyl fluorides which can be used as starting materials for active fungicidal ingredients by a halex reaction. | 2009-12-10 |
20090306402 | Composition of N-Alkenyl Carboxylic Acid Tertiary Amide - A composition of N-alkenyl carboxylic acid tertiary amide which enables to suppress variation of pH and color valency and realize storage stability for a long period, by the addition of specified amines. | 2009-12-10 |
20090306403 | Production Process for Bicyclic Tetrahydropyrrole Compounds - The present invention relates to a process using the Pauson-Khand Reaction to produce substituted bicyclic tetrahydropyrrole compounds of general formula (I) | 2009-12-10 |
20090306404 | Process for the Preparation of 2-azabicyclo[3.3.0]octane-3-carboxylic Acid Derivatives - The present invention is aimed at a process for the preparation of compounds of the general formula (I). | 2009-12-10 |
20090306405 | PROCESS FOR MAKING N-HYDROXY-3-[4-[[[2-(2-METHYL-1H-INDOL-3-YL)ETHYL]AMINO]METHYL]PHENYL]-2E- -2-PROPENAMIDE AND STARTING MATERIALS THEREFOR - N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide and starting materials therefor are prepared by new synthetic methods. | 2009-12-10 |
20090306406 | METHOD FOR PREPARING 1,3-DISUBSTITUTED PYRROLIDINE COMPOUNDS - A process for preparing substituted pyrrolidine compounds, including (5)-2-{1-[2-(2,3-dihydrobenzofuran-5-yl)ethyl]-3-pyrrolidinyl}-2,2-diphenylacetamide hydrobromide, commonly known in the art as darifenacin, comprising reacting a pyrrolidine compound with a benzofuran derivative in the presence of a phase-transfer catalyst. | 2009-12-10 |
20090306407 | Pyrrolidine analogue for preventing neurogenic pain and method for production thereof | 2009-12-10 |
20090306408 | 2-Amino-Bicyclo (3.1.0) Hexane-2,6-Dicarboxylic Ester Derivative - A drug effective for the treatment and prevention of psychiatric disorders such as schizophrenia, anxiety and related ailments thereof, depression, bipolar disorder and epilepsy. The drug antagonizes the action of group II metabotropic glutamate receptors and shows high activity in oral administration | 2009-12-10 |
20090306409 | MULTI-LAYER CATALYST FOR PRODUCING PHTHALIC ANHYDRIDE - The present invention relates to a catalyst for preparing phthalic anhydride by gas phase oxidation of o-xylene and/or naphthalene, comprising at least three catalyst zones which have different compositions and, from the gas inlet side toward the gas outlet side, are referred to as first, second and third catalyst zone, the catalyst zones having in each case an active composition comprising TiO | 2009-12-10 |
20090306410 | SHAPED CATALYST BODY FOR PARTIAL OXIDATION REACTIONS - The invention relates to a shaped catalyst body for preparing maleic anhydride, which comprises mixed oxides of vanadium and of phosphorus as catalyst components. To develop a generic shaped catalyst body further so that it has improved properties, it is proposed that the basic geometric body enveloping the shaped catalyst body ( | 2009-12-10 |
20090306411 | PROCESS FOR PREPARING UNSATURATED LACTONES - The invention relates to a process for preparing saturated or unsaturated lactones. This process involves reacting a bicyclic compound or a monocyclic compound with hydrogen peroxide in the presence of a first acid having a pK | 2009-12-10 |
20090306412 | 4-HYDROXYTHIOBENZAMIDE DERIVATIVES OF DRUGS - Derivatives of drugs are provided, said derivatives comprising the H2S-releasing moiety 4-hydroxythiobenzamide that is either covalently linked to the drug or forms a salt with the drug. The compounds of the present invention exhibit enhanced activity or reduced side effects or both. | 2009-12-10 |
20090306413 | Method for preparing 2,5,7,8-tetramethyl-2-(2'-carboxyethyl)-6-acetoxyromane-precursor- alpha-cehc precursor - The contemplated invention relates to the field of synthesis of biologically active substances, namely to the synthesis of an acetate derivative of the main water-soluble α-tocopherol metabolite known under the name of α-CEHC, which is prepared by the acid-catalyzed reaction of condensation of trimethyl hydroquinone with linalool in boiling octane, using n-toluenesulfonic acid or (+)-camphor-10-sulfonic acid as the catalyst. The reaction is carried out for 3 hours at the trimethyl hydroquinone:linalool:catalyst mole ratio of 1:1:0.1. The forming product is acetylated with acetic anhydride in pyridine at room temperature for 0.5 hour, and then ozonized in acetone in the presence of Ba(OH) | 2009-12-10 |
20090306414 | Microchannel Reactor - The present invention provides a microchannel reactor that is used as a new reaction device capable of greatly expanding the utilization range of chemical reactions occurring in microspaces. A solution of a soluble linear polymer containing ligands and a solution of a soluble transition metal molecule are individually introduced into a microreactor, the flows are merged inside a microchannel and a metal polymer membrane of a complex formed is generated at the interface of the flows. The membrane is used as a solid catalyst, and various reactions such as carbon-carbon bond formation reactions, oxidation reactions and the like can be conducted at extremely fast reaction rates. | 2009-12-10 |
20090306415 | Method For The Synthesis Of Organic Acid Esters Of 5-Hydroxymethylfurfural And Their Use - Method for the manufacture of organic acid esters of 5-hydroxymethylfurfural by reacting a fructose or glucose-containing starting material with an organic acid or its anhydride in the presence of a catalytic or sub-stoechiometric amount of solid acid catalyst. The catalysts are heterogeneous and may be employed in a continuous flow fixed bed reactor. The esters can be applied as a fuel or fuel additive. | 2009-12-10 |
20090306416 | Propylene oxide process - A process for making propylene oxide from propylene is disclosed. The process comprises reacting propylene, oxygen, and hydrogen in the presence of a catalyst, a solvent, and a buffer to produce a reaction mixture comprising propylene oxide. Separation of light components from the reaction mixture gives a heavy residue comprising the buffer. The buffer is precipitated from the heavy residue by a precipitating agent. | 2009-12-10 |
20090306417 | Process for the preparation of 7alpha-alkylated 19-norsteroids - Processes useful in the preparation of pharmaceutical compounds such as fulvestrant and processes for the preparation of fulvestrant. | 2009-12-10 |
20090306418 | Process for Preparing Alpha-Sulfo-Fatty Acid Ester Salt Surfactants - A process for preparing an α-sulpho-fatty acid ester salt surfactant comprises: (1) sulphating a fatty acid ester with SO | 2009-12-10 |
20090306419 | Method for Degumming Triglyceride Oils - A system and method of degumming a plant derived oil comprising mixing a feed stream under ultrahigh shear conditions to provide a mixed stream, passing the mixed stream through a retention tank, and separating the mixed stream into an aqueous stream and an oil stream is disclosed. The feed stream comprises water, optional added acid(s), and triglyceride oil, such as a plant derived oil, having a relatively high phosphorous content and may also include metal impurities such as calcium, magnesium and/or iron ions. The process can provide a triglyceride oil stream with a phosphorous content of no more than about 10 to 20 ppm and no more than about 0.5 wt. % free fatty acids. In many instances, the triglyceride oil stream has phosphorous content which is no more than about 3% of the phosphorous content of the feed stream. The process also provides a wet gum stream, which may have an AI of 75 or higher. | 2009-12-10 |